Search

This work is the first compilation of comprehensive deliberations on botany, cytogenetics and sex determination, genetic resources and diversity, classical breeding, molecular markers and genome sequence resources, and application of omics technology including transcriptomics, proteomics, and metabolomics resources in the multipurpose medicinal plant seabuckthorn. The book also presents a detailed narrative on antioxidative, radioprotective nutraceutical, and medicinal applications of seabuckthorn products. A detailed treatment has been included on analytical techniques and processing technologies. Altogether, the book contains about 300 pages over 17 chapters contributed by globally reputed experts on the relevant field in this important plant species. This book will be useful to the research students, teachers, and scientists in the academia and private sector engaged in horticulture, genetics, breeding, molecular biology, biotechnology, and breeding. The book will also be a useful source for workers involved in the development of plant-based medicines, nutraceuticals, therapeutics, and cosmeceuticals and extension workers involved in the development of rural farmers and small-scale industries.

This book illustrates the basics and underlying molecular machinery of cancer cells and biochemical assays that detect the type and stage of cancer through cell signaling biomarkers. It starts with a brief introduction to cancer biomarkers and addresses technologies for identifying and validating cancer biomarkers, biomarkers for cancer drug development, prognostic and diagnostic biomarkers, and microbiome as cancer biomarkers. It reviews predictive biomarkers for anticancer drugs, biomarkers in cancer survival and drug resistance, biomarkers in tumor recurrence and metastasis, the role of the biomarker in immunotherapy and personalized medicine, and the development of a novel cancer biomarker. Finally, this book also underpins the role of nanotechnology in the use and detection of cancer biomarkers for enhanced sensitivity and specificity. Lastly, it discusses the challenges with biomarkers in cancer drug discovery and development. This volume is an indispensable tool for researchers working in the field of cancer and also for clinical oncologists.

This book is a multidisciplinary guide to head and neck cancer.Head and neck cancer remains one of the most technically complex cancer subsites to manage. This field involves highly specialized, multidisciplinary management and collaboration amongst surgeons, radiation oncologists, medical oncologists, radiologists, pathologists, and other health disciplines. The clinical and research landscape for head and neck oncology continues to evolve at a rapid pace. This multidisciplinary book provides the latest updates in the contemporary understanding and management of these tumors. The text incorporates updates in surgical techniques (minimally invasive and robotic techniques, reconstructive approaches), radiation medicine (new data on dose and fields, oligometastatic/oligoprogressive disease, retreatment), medical oncology (targeted, immunotherapy and molecular agents), in addition to other overarching topics such as side effects, biomarkers/nanotechnology, and epidemiology. Written by experts in their respective fields, chapters include the most up to date scientific and clinical information with perspectives from each relevant subspeciality. These sections are concise and accessible, yet comprehensive. Palliative medicine, pathologic and imaging principles, and health systems/economics considerations are also described. This book is an ideal resource for clinicians, trainees, and researchers dealing with, and interested in, this challenging malignancy.

This book provides up-to-date guidance that will assist radiation oncologists during the day-to-day management of nasopharyngeal cancer. After discussion of diagnosis and staging, target delineation techniques and treatment planning are described for both intensity-modulated and particle radiation therapy. Detailed information is then presented on the application of radiation therapy in different disease settings, from early stage disease to metastatic disease. Due attention is paid to the role of multimodality treatment and new and advanced technologies in particular circumstances, such as local recurrence. In addition, follow-up and the management of late toxicities are explained and management strategies are documented for special situations and groups, including pediatric patients. The book is published within the Springer series Practical Guides in Radiation Oncology. Like other volumes in the series, it is designed for hands-on use by both radiation oncology residents and practicing radiation oncologists. It will also be of value for head and neck physicians.

This book is an evidence-based guide to current use of radiation therapy for the treatment of malignancies at major disease sites. It is designed to meet the needs of residents, fellows, and practicing radiation oncologists and will assist in selection and delineation of tumor volumes/fields and dose prescription for intensity-modulated radiation therapy, including volumetric modulated arc therapy for stereotactic radiosurgery or stereotactic body radiotherapy. Each tumor site-related chapter presents, from the perspective of an academic expert, informative cases at different stages in order to clarify specific clinical concepts. The coverage includes case presentation, a case-related literature review, patient preparation, simulation, contouring, treatment planning, image-guided treatment delivery, follow-up, and toxicity management. The text is accompanied by illustrations ranging from slice-by-slice delineations on planning CT images to finalized plan evaluations based on detailed acceptance criteria. The expert knowledge and evidence contained in this comprehensive book will give readers the confidence to manage common cancers without outside referral and to meet the clinical challenges faced in everyday practice.

This book is specifically designed to provide information about various nanocarriers currently developed under the emerging field of nanotheranostics for a sustained, controlled, and targeted co-delivery of diagnostic and therapeutic agents. Diverse theranostic applications of nanotechnology and their limitations are also addressed. It integrates nanobiotechnology with theranostic applications. The combined term nanotheranostics has diverse application particularly in chemotherapy and other infectious diseases.Among other topics addressed are antimicrobial resistance, targeting intra-cellular pathogens, viruses and bacteria, chemotherapy, cancer therapeutics, and inflammatory disorders. This interdisciplinary volume is essential for a diverse group of readers including nanotechnologists, microbiologists, biotechnologists, bioengineering and bioprocess industry.

Das Nachschlagewerk für die Weiterbildung und die praktische Arbeit in der Klinik erscheint mit neuem Herausgeberteam komplett überarbeitet und präsentiert kompakt zusammengefasst die Highlights der aktuellen pädiatrischen Hämatologie und Onkologie. Verständlich und ohne Ballast präsentiert, ist das Buch für Spezialisten auf dem Gebiet ebensogut geeignet wie als anwendungsbezogener Einstieg in die Thematik. Das Werk ist in drei übersichtliche Abschnitte eingeteilt: die pädiatrische Hämatologie und Hämostaseologie, die allgemeine pädiatrische Onkologie und die spezielle pädiatrische Onkologie. Hier werden Leukozyten und Lymphome sowie solide Tumoren besprochen, darunter Tumoren im Zentralnervensystem, im Bauch und die Sarkome. Eine klare und einheitliche Einteilung jedes Krankheitsbildes macht das Buch übersichtlich und gut zugänglich von der Epidemiologie über die Pathogenese, Klassifikation, klinische Präsentation bis zu Diagnostik, Differenzialdiagnostik und prognostischen Faktoren. Die Therapie umfasst die Einordnung in internationale Konzepte und wird jeweils mit einem übersichtlichen Therapiealgorithmus einschließlich der Heilungsraten präsentiert. Zukünftige Therapieoptionen unter Einschluss möglicher Rezidive runden die Kapitel ab. Die Expertise führender pädiatrischer Onkologen und Hämatologen aus dem gesamten deutschsprachigen Raum sorgt dafür, dass dieses Buch das zeitgemäße Nachfolgewerk des ehemals von Gadner/Gaedicke/Niemeyer/Ritter herausgegebenen Standardwerks zur pädiatrischen Hämatologie und Onkologie wird. Das Buch richtet sich an Ärzte in Weiterbildung der Kinder- und Jugendmedizin und an alle pädiatrischen Onkologen bzw. Hämatologen.

This book presents the most up-to-date and innovative information on the targeting and treatment of a wide range of childhood cancers by means of radiation therapy. Written by global experts in pediatric radiation oncology, it documents in detail the treatment regimens appropriate to each disease, highlighting the recent advances that promise to improve rates of survival and cure. The use of image-guided and intensity-modulated radiation therapy is clearly described, and careful attention is also devoted to the roles of proton therapy, stereotactic radiosurgery, stereotactic fractionated radiosurgery, and modulated arc radiotherapy. Separate chapters address localization and verification procedures and anesthesia; pediatric radiation oncology in the palliative care setting; and aspects that are especially relevant in low- and medium-income countries. Beyond clinical radiation oncology, relevant information is provided on radiation physics. The book concludes by examining future directions in the field.

This book provides an overview of the latest advances in head and neck cancer using a multidisciplinary approach. Commencing with a discussion of epidemiological and diagnostic aspects, including the role of vaccination and key pathological features, the book then follows by examining the role of oncogenomics, proteomics, next generation sequencing and homologous recombination function in predicting outcomes. The topics are presented by epidemiologists, pathologists and basic scientists with further contributions from medical oncologists, head and neck cancer surgical specialists (ORL /HNS), and radiation oncologists in chapters that discuss therapeutic approaches for oral, oropharyngeal and thyroid cancer. Special topics such as the development of novel staging classifications, optimal larynx preservation approaches for laryngeal and hypopharyngeal cancer, surgical reconstruction, new surgical approaches in oropharynx cancer, potential for treatment de-escalation, systemic therapyin nasopharyngeal cancer and salivary gland tumors and treatment approaches for tumors of unknown primary site are discussed in detail. Finally, the role of immunotherapy in the field is highlighted. The chapters are based on the latest data presented at the 6th Trends in Head and Neck Oncology Conference and reflect the most up-to-date information in the field. They are written by many of the most internationally acclaimed authors in the field and are therefore an excellent source for all those interested or actively working in the field of head and neck cancer.

This book, now in its second edition, provides a comprehensive overview of current re-irradiation strategies, with detailed discussion of re-irradiation methods, technical aspects, the role of combined therapy with anticancer drugs and hyperthermia, and normal tissue tolerance. In addition, disease specific chapters document recent clinical results and future research directions. All chapters from the first edition have been revised and updated to take account of the latest developments and research findings, including those from prospective studies. Due attention is paid to the exciting developments in the fields of proton irradiation and frameless image-guided ablative radiotherapy. The book documents fully how refined combined modality approaches and significant technical advances in radiation treatment planning and delivery have facilitated the re-irradiation of previously exposed volumes, allowing both palliative and curative approaches to be pursued at various disease sites. Professionals involved in radiation treatment planning and multimodal oncology treatment will find it to be an invaluable aid in understanding the benefits and limitations of re-irradiation and in designing prospective trials.

The book conveys a comprehensive knowledge of long and short ncRNAs in cancer regulation and their potentials as diagnostic biomarkers and therapeutic targets. Topics covered include the molecular mechanisms of various classes of ncRNAs (with emphasis on long non-coding RNAs and microRNAs) in cancer, the functional roles of ncRNAs in regulating different cancer hallmarks (including proliferation, apoptosis, stem-cell properties, epithelial-mesenchymal transition, metabolism, angiogenesis, tumor-host interactions and therapeutic resistance), the role of ncRNAs in regulating cancer signaling circuitry programs (highlighting their involvement in c-myc, p53 and NFkB signaling), a systemic summary of clinical and preclinical studies that evaluate the potential of ncRNA signatures for cancer diagnosis and prognosis and strategies to delivery short ncRNAs as therapeutic molecules for cancer treatment. This book may serve as a comprehensive resource for researchers, graduate students and oncologists in ncRNA and cancer research and help drug development by identifying ncRNA targets.

​This second edition ​provides a comprehensive view of consolidated and innovative concepts, in terms of both diagnosis and treatment. Written by leading international physicians and investigators, this book emphasizes the necessity of combining local and systemic treatments to achieve the objective of yielding higher cure rates and lower toxicities. Heavily updated from the previous edition, it highlights new surgery and radiotherapy techniques, disease awareness, patient quality of life, and comprehensive management. Head-and-neck cancers are a complex clinical entity and their response to treatment is also known to vary markedly in function of host-related factors. Notwithstanding the impressive progresses observed in the field of imaging, head and neck cancers are often diagnosed at a late stage and the presence of locally advanced disease in a significant number of patients implies the use of aggressive treatments in order to both ensure local disease control and reduce distant metastasis risks. In comparison with the first edition, Head and Neck Cancer, Second Edition provides a detailed update of innovative concepts in chemo- and bio-radiation, viral infection impact on tumor growth and response to treatment, and impact of tumor- and host-related factors on treatment outcome.

This volume includes the information necessary to understand recent critical advances in the mechanisms of intestinal tumorigenesis and to comprehend the complexity of the process. The volume aims to entice new researchers to participate in relevant studies, and to provide a forum for discussion within the scientific community to shape future research in this field. Discoveries in intestinal tumorigenesis lead to further understanding of mechanisms involved in colon cancer. Additionally, advancements in techniques and methods open the doors for new approaches to better define the molecular and organismal mechanisms of intestinal tumorigenesis. Chapters are authored by widely published authorities in the field.Each year, there are close to 150,000 new cases of colorectal cancer, which results in approximately 50,000 deaths per year in the United States; these figures render colorectal cancer a significant health concern. Studies attempting to understand the mechanisms of development and progression of colorectal cancer have been ongoing for decades and each year brings new discoveries yielding a better comprehension of the underlying processes at work.

Principles and Practice of Stereotactic Radiosurgery, Second Edition serves as the definitive reference textbook for SRS practitioners. It provides a theoretical basis for the use of therapeutic radiation including imaging techniques and radiobiology. The bulk of the textbook contains chapters that are comprehensive in scope on all diseases that are treated by SRS. Lastly, it addresses administrative and technical aspects of running an SRS unit. Each chapter provides an expansive treatment of the subject, with emphasis placed on the technical aspects of SRS so that practitioners in this field can use it as a daily reference.Written by noted experts in the field, Principles and Practice of Stereotactic Radiosurgery, Second Edition is the only reference needed for neurosurgeons, radiation oncologists and medical physicists at all levels of training and practice who are interested in SRS.

Head and neck squamous cell carcinoma (HNSCC), the sixth most prevalent cancer worldwide, remains a very difficult disease to treat and cure despite intensive investigation into molecular etiologies and tumor progression pathways. Due to public health efforts encouraging smoking cessation, the overall incidence of HNSCC has decreased in recent years in many countries. In contrast, the incidence of oropharyngeal squamous cell carcinoma (OPSCC) has increased significantly, and this subtype of HNSCC is commonly associated with human papillomavirus (HPV) infection. Moreover, individuals with HPV-positive OPSCC are generally younger and are frequently non-smokers, suggesting that HPV-associated OPSCC represents a distinct biologic entity.This volume summarizes the spectrum of current HPV-associated OPSCC research from the fundamental basic science to translational surgery and treatment approaches. Chapters are contributed by authoritative leaders in the fields of research and clinical care. Initial chapters address epidemiology, behavioral correlates of HPV infection, and racial disparities in oropharyngeal cancer. This is followed by chapters detailing HPV virology with focus on viral transformation, viral replication, and host response to viral infection. The molecular biology of HPV-associated OPSCC is investigated in chapters detailing alterations in signaling networks and unique mutational profiles of human tumors. Clinical presentation, surgical perspectives, and treatment paradigms specific to HPV-associated OPSCC conclude the volume. This comprehensive volume provides an up-to-date overview of both scientific discovery and clinical management of this emerging public health problem.

This volume thoroughly explores of the functional role of microRNAs in cancer. It not only expertly describes the molecular mechanisms underlying the malignant transformation process but also compiles cutting-edge research on microRNAs in several forms of cancer, including colorectal cancer, pancreatic cancer, leukemia/lymphoma, prostate cancer, lung cancer, ovarian cancer, and bone cancer. Distinguished experts, currently working in prestigious institutions, elegantly discuss these fundamental themes. The text, which opens with a foreword by the renowned Dr. Carlo M. Croce, is enhanced by abundant color photographs, schemes, diagrams, and tables that fully support and complement the content.microRNA: Cancer is an ideal companion to both microRNA: Basic Science andmicroRNA: Medical Evidence. Taken together, these three books provide a state-of-the-art overview of this rapidly-expanding and fascinating field, from the molecular level to clinical practice. It will be invaluable to medical students, physicians, and researchers, as a complete and unique guide in the exploration of microRNA in basic science, cancer and clinical practice.

Successful clinical use of intensity-modulated radiation therapy (IMRT) represents a significant advance in radiation oncology. Because IMRT can deliver high-dose radiation to a target with a reduced dose to the surrounding organs, it can improve the local control rate and reduce toxicities associated with radiation therapy. Since IMRT began being used in the mid-1990s, a large volume of clinical evidence of the advantages of IMRT has been collected. However, treatment planning and quality assurance (QA) of IMRT are complicated and difficult for the clinician and the medical physicist. This book, by authors renowned for their expertise in their fields, provides cumulative clinical evidence and appropriate techniques for IMRT for the clinician and the physicist. Part I deals with the foundations and techniques, history, principles, QA, treatment planning, radiobiology and related aspects of IMRT. Part II covers clinical applications with several case studies, describing contouring and dose distribution with clinical results along with descriptions of indications and a review of clinical evidence for each tumor site. The information presented in this book serves as a valuable resource for the practicing clinician and physicist.