1. Contactin-associated protein 2 autoantibodies can be associated with multifocal motor-like neuropathy: a case report.
- Author
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Müller-Miny, Louisa, Sauer, Raoul, Schulte-Mecklenbeck, Andreas, Gross, Catharina C., Kovac, Stjepana, Schilling, Matthias, Beuker, Carolin, Wiendl, Heinz, and Meyer zu Hörste, Gerd
- Subjects
AUTOANTIBODIES ,NEUROPATHY ,ISAACS syndrome ,DIAGNOSTIC use of flow cytometry ,NEURAL conduction - Abstract
Autoantibodies against contactin-associated protein 2 (CASPR2) are usually associated with autoimmune encephalitis and neuromyotonia. Their association with inflammatory neuropathies has been described in case reports albeit all with distal symmetric manifestation. Here, we report a patient who developed distal arm paresis, dominantly of the right arm, over the course of 1 year. Electroneurography showed a conduction block of motor nerve conduction, nerve ultrasonography a swelling of the right median and ulnar nerve and flow cytometry an increase in natural killer (NK cells) in the blood and natural killer T (NKT) cells in the cerebrospinal fluid (CSF), therefore indicating a multifocal motor neuropathy-like (MMN-like) phenotype. CASPR2 autoantibodies were detected in serum and CSF. Through immunotherapy with intravenous immunoglobulins the patient showed clinical and neurographic improvement. We therefore describe the first association of CASPR2 autoantibodies with a MMN-like clinical manifestation, extending the spectrum of CASPR2-associated diseases. [ABSTRACT FROM AUTHOR]
- Published
- 2023
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