Search

In combination with Bayesian estimates based on a population pharmacokinetic model, limited sampling strategies (LSS) may reduce the number of samples required for individual pharmacokinetic parameter estimations. Such strategies reduce the burden when assessing the area under the concentration versus time curves (AUC) in therapeutic drug monitoring. However, it is not uncommon for the actual sample time to deviate from the optimal one. In this work, we evaluate the robustness of parameter estimations to such deviations in an LSS. A previously developed 4-point LSS for estimation of serum iohexol clearance (i.e., dose/AUC) was used to exemplify the effect of sample time deviations. Two parallel strategies were used: (a) shifting the exact sampling time by an empirical amount of time for each of the four individual sample points, and (b) introducing a random error across all sample points. The investigated iohexol LSS appeared robust to deviations from optimal sample times, both across individual and multiple sample points. The proportion of individuals with a relative error greater than 15% (P15) was 5.3% in the reference run with optimally timed sampling, which increased to a maximum of 8.3% following the introduction of random error in sample time across all four time points. We propose to apply the present method for the validation of LSS developed for clinical use. [ABSTRACT FROM AUTHOR]

Fast capacity estimation is a key enabling technique for second-life of lithium-ion batteries due to the hard work involved in determining the capacity of a large number of used electric vehicle (EV) batteries. This paper tries to make three contributions to the existing literature through a robust and advanced algorithm: (1) a three layer back propagation artificial neural network (BP ANN) model is developed to estimate the battery capacity. The model employs internal resistance expressing the battery's kinetics as the model input, which can realize fast capacity estimation; (2) an estimation error model is established to investigate the relationship between the robustness coefficient and regression coefficient. It is revealed that commonly used ANN capacity estimation algorithm is flawed in providing robustness of parameter measurement uncertainties; (3) the law of large numbers is used as the basis for a proposed robust estimation approach, which optimally balances the relationship between estimation accuracy and disturbance rejection. An optimal range of the threshold for robustness coefficient is also discussed and proposed. Experimental results demonstrate the efficacy and the robustness of the BP ANN model together with the proposed identification approach, which can provide an important basis for large scale applications of second-life of batteries. [ABSTRACT FROM AUTHOR]