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To understand evolution better, biologists should take into account the development of an organism's reaction to stressors (i.e.,the secondary action of a stressor) during development, and the subtle role it plays. Hormesis and homeopathic phenomena are just names to classify such secondry properties. These phenomena exploit the secondary action, below that of a pharmacological of toxin dose in a beneficial fashion. An intriguing examination of the biological behavior of the secondary action leads to the proposed theory. Hormesis seems to be an evolutionary adaptation that provides a buffer against environmental changes. Through the chemical routes, it paved a way for the evolution of molecular mechanisms which gave rise to homeopathic phenomenon. As serial turbulent dilution of environmental stressors is a part of nature, such molecular mechanisms were compelled to develop further, making an organism sensitive to ultramolecular dilution in terms of beneficial secondary action. Nanoparticles along with interfacial water can carry stressor-specific information. Thus the first true medicinal effects which evolved during early life were homeopathic in nature and environmental hormetic stressors were their precursors. Homeopathy is an adaptive stress-response therapy. While hormesis causes enzymatic and some transcriptional genetic changes, homeopathy operates on a different level of epigenetic modifications. The proposed theory predicts that the hormesity of nonhormetic toxins, at least those with which life evolved, is contained in ultramolecular dilutions. Experimental support is emerging for this theory, and some suggestions have been given for testing and verification. As this theory concerns the evolution of the earliest medicine with an intrinsic role in the evolutionary process, it could influence the whole field of medical science. [ABSTRACT FROM AUTHOR]