1. Association of severe hypoglycemia with all-cause mortality and complication risks among patients with type 2 diabetes mellitus in China.
- Author
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Zhang, Jiahui, He, Xiaoning, Zhang, Lin, Wang, Ke, Chen, Hong, and Wu, Jing
- Subjects
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TRANSIENT ischemic attack , *TYPE 2 diabetes , *HYPOGLYCEMIA , *CHINESE people , *MYOCARDIAL infarction , *CASE-control method , *DISEASE incidence , *LONGITUDINAL method , *DISEASE complications - Abstract
Aims: To investigate the association of severe hypoglycemia (SH) with all-cause mortality and complication risks among Chinese patients with type 2 diabetes mellitus (T2DM).Methods: Cohort study and nested case-control studies were conducted based on medical insurance database 2008-2015. The incidence of outcomes or the exposure of previous SH was compared among matched patients, respectively. The association between SH and outcomes was investigated and validated by different models.Results: Among cohort study participants (mean age of 59.0 ± 11.2 years), SH was associated with higher risk of all-cause mortality (HR = 1.80, P < 0.001) and transient ischemic attacks (TIA, HR = 1.51, P < 0.001), while no association was observed between SH and complications including myocardial infarction (MI), angina, arrhythmia and stroke. Similarly, SH was associated with about doubled all-cause mortality (OR = 1.76, P < 0.001) and TIA (OR = 2.00, P < 0.001), but not associated with risk of MI or stroke in nested case-control studies.Conclusions: In Chinese patients with T2DM, SH is associated with increased risk of all-cause mortality and TIA, but no significant differences were found regard to the other examined complication risks, which need to be further explored in future studies. [ABSTRACT FROM AUTHOR]- Published
- 2020
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