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This study aimed to synthesis and characterized silver nanoparticles using Iraqi propolis then inversigate their ability in induce of phagocytic cells. The Synthesis of Silver nanoparticles by on the green synthesis was confirmed using different parameters, color changes, and then conformed by of UV visible spectroscopy. The morphology was characterized by SEM. Moreover, their effectiveness in stimulation of Phagocytosis had been studied. The results showed significant increases in the ability of phagocytic cells in the presence of nanoparticles as compared with non-treated cells. The results suggested that silver nanoparticles synthesis using Iraqi propolis act as immunomodeulater and could be used for pharmaceutical applications. [ABSTRACT FROM AUTHOR]