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Autophagy Processes and Mechanisms details the process of autophagy and its significance in diseases and aging. It provides insights into autophagy mechanisms and processes to broaden our understanding. By collecting recent progress on several aspects of the autophagy process, it provides a more integrative perspective and serves as a resource that can influence future research initiatives in the field. This new book is appropriate for basic and applied researchers in cell biology, biologists and those working in the pharmaceutical sciences. - Includes cutting-edge knowledge on autophagy processes as well as methodologies of research - Integrates knowledge from the perspectives of basic biological science, bioinformatics, clinical research and the pharmaceutical sciences - Provides an educational resource for students and investigators with an interest in autophagy, but who are not currently working in the field

Terpene Synthases, Volume 700 in the Methods in Enzymology series, continues the legacy of this highly respected laboratory standard with its first dedicated collection on this important family of enzymes. Terpene synthases are a diverse set of enzymes that use exquisite mechanisms to form complex (poly)cyclic hydrocarbon skeletons. Chapters in this new volume include Structural analysis by X-ray crystallography and cryo-EM, Understanding mechanisms using stable isotopes, substrate analogs, or computational tools, Engineering fusion enzymes, Ancestral terpene cyclases, as well as the Sequence, structure, and function of non-canonical terpene synthases. - Presents the only collection of current methodology for the investigation of terpene synthases, with topics including from bioinformatics, enzymology, computational chemistry, and engineering - Includes chapters authored by international experts in the field - Provides the latest contributions in the leading serial Methods in Enzymology

Nonclinical Development of Biologics, Biosimilars, Vaccines and Specialty Biologics, Second Edition is a complete reference devoted to the nonclinical safety assessment of novel biopharmaceuticals, biosimilars, vaccines, cell and gene therapies and blood products. Updated and revised, the new edition compares and contrasts these types of biologics with one another and with small molecule drugs, while incorporating the most current and essential international regulatory guidelines. Each section discusses a different type of biologic, as well as early characterization strategies, principles of study design, preclinical pharmacokinetics and pharmacodynamics and preclinical assays. A multi-edited book with chapters authored by leading qualified experts in the field, this comprehensive reference provides critical insights to all researchers involved in early through late-stage biologics. - Provides in-depth coverage of the process of nonclinical safety assessment and comprehensive reviews of each type of biopharmaceutical - Discusses the most pertinent international regulatory guidelines - Covers early derisking strategies and designs of safety assessment programs for novel biopharmaceuticals and vaccines

Sustainable Agriculture under Drought Stress: Integrated Soil, Water and Nutrient Management seamlessly blends cutting-edge research with practical applications, offering a unique perspective on tackling this urgent challenge. Through a multidisciplinary lens, this book provides a cohesive and comprehensive understanding of both the current landscape and future prospects. Readers will find this book equips them with the knowledge and strategies required to manage soil nutrients and water effectively, ensuring the health of both soil and plants, especially in arid and semi-arid regions, where solutions are urgently needed. This book offers actionable insights into mitigating the impacts of climate change on agricultural systems, making it essential reading for anyone invested in sustainable land management and food security. - Clarifies mechanisms and proposes solutions for enhancing soil health and fertility, irrigation management, and crop production in drought-stressed environments - Presents a diverse array of options for responding to drought stress, optimizing plant health and furthering sustainability - Explores emerging cropping systems and opportunities

Hepatology: An Evidence-Based Clinical Compendium provides current and comprehensive insights into the field of hepatology, covering various aspects such as diagnosis, management, control, techniques, procedures, and technology. By offering the latest information, the book ensures that readers stay up-to-date with the rapidly evolving landscape of hepatology. The comprehensive scope covers a wide range of topics related to liver diseases, including epidemiology, pathogenesis, and pathophysiology. It features contributions from esteemed experts worldwide and is enhanced with high-quality diagrams. The book serves as a valuable resource for scientists and researchers, offering a solid foundation for their investigations and clinical inquiries.Moreover, the book goes beyond the discussion of epidemiology, pathogenesis, and pathophysiology, and presents updated treatment and management guidelines for liver diseases, making it a go-to reference for Clinicians treating liver diseases. - Presents current and comprehensive insights into the diagnosis, management, control, techniques, procedures, and technology in hepatology - Facilitates evidence-based decision-making for better patient care, enabling practitioners to effectively incorporate research findings into their treatment approaches - Guides the selection of optimal treatment and management options, equipping readers with valuable resources to overcome challenges encountered in clinical practice - Enhances knowledge and skills for clinical practice, offering valuable support to healthcare professionals seeking to improve their expertise

The Charnolosome as a Novel Nanothereranostic Biomarker: Overcoming Future Challenges in Medicine provides an overview of the charnolosome and its potential as a biomarker of cell injury. Based on the author's original discovery of the charnoly body in the developing, undernourished rat cerebellar Purkinje neurons, this book delves into the potential for utilizing this mitochondria and lysosomal-derived intracellular organelle as a nanotheranostic biomarker to prevent and cure various diseases. The book discusses the cellular, molecular, genetic, and epigenetic mechanisms of charnolosomes and charnolosome-derived nano-vesicles. It also investigates the molecular mechanisms underlying auto-inflammatory, autoimmune, and infectious diseases resulting from their compromised mitochondrial bioenergetics, and the potential use of the charnolosome in preventing and curing such conditions. - Shares the latest knowledge on the charnolosome and charnolosome-derived nano-vesicles and their significance at a cellular and molecular level - Considers the charnolosome in relation to a range of conditions, including neurodegenerative, metabolic, and multi-drug resistant systemic diseases - Presents future perspectives of the charnolosome in personalized nanotheranostics

The Immunology of the Cat makes available the first single-source, comprehensive review of the feline immune system, reporting on all immunologic aspects of diseases of the cat and its relatives and relating recent basic science to important clinical issues. The book opens with the evolution, domestication, and development of the cat then provides detailed information on immunity to infectious diseases, feline allergic diseases, the top feline autoimmune diseases, and feline immunodeficiencies. Content examines feline vaccines, hypersensitivity, cancer, nutrition, and the aged cat. Professionals in veterinary research and practice will appreciate complete information on all aspects of feline immunology in one essential resource. - Introduces the first comprehensive review of feline immunology - Links recent basic science to important clinical issues - Provides detailed and current information in one resource

Caspases as Molecular Targets for Cancer Therapy discusses the recent developments on targeted therapies for cancer using caspases. It describes the selection of specific caspases for cancer therapy with the current standard of care and highlights numerous assay techniques for caspase activities. This book discusses topics such as mutations within apoptosis gene, inflammatory caspases, tumor suppression, and the different caspase types and their role in anticancer activity. In addition, it discusses caspase activity assay procedure and future perspectives. It is a valuable resource for researchers, students, and members of biomedical and medical fields who want to learn more about novel anticancer targeted therapies. - Discusses thoroughly caspases, their mechanism of action, and mutations responsible for the development of cancer. - Presents updated literature of synthetic compounds for the development of caspase-mediated new anticancer drugs. - Encompasses comprehensive compilation of recently introduced anticancer drugs in the market, the health outcomes, and pharmacoeconomics.

The immune system is a group of complex biological structures and processes in an organism which gives protection against wide range of pathogenic organisms and simultaneously distinguishes these pathogens from organism's own healthy cells and tissues, thus maintaining homeostasis in the body. It has been an age-old practice to use extracts and other parts of various plants in treating many diseases. Several plants contain various pharmacologically active substances, which can be used to treat different diseases. Among these medicinal plants many have shown good immunomodulatory properties and could act as natural immunosuppressant agents in treating autoimmune disorders. In 12 chapters, besides covering the basic concepts of immune system and its function, Autoimmune diseases and Medicinal Plants provides a comprehensive knowledge of autoimmune diseases and the role of various medicinal plant products in their treatment - Elucidates in-depth knowledge on the basics of Immunology, as well as the various autoimmune disorders and the medicinal plant extracts which could be an alternative and safe approach for their treatment and management - Provides updated content on the role of different medicinal plants in curing autoimmune diseases - Includes a section at the end of each autoimmune disease, giving a comparison between the treatment with conventional drugs and the medicinal plant products - Explains the benefits and risks of both treatment regimens in comprehensive, yet easily understandable way

Mechanisms of Disease Pathogenesis in Multiple Sclerosis summarizes our current understanding on MS and its clinical features and monitoring with available biomarkers, focusing on mechanisms that drive disease pathogenesis and their control by genetic, environmental factors and novel therapies for disease management. The book is written for neurologists, neuroimmunologists and clinical, translational and basic researchers interested in mechanisms of neurodegeneration. Multiple Sclerosis (MS) is an autoimmune disease which targets the central nervous system (CNS). It is the most common cause of non-traumatic neurological disability in young adults with a prevalence of 1 in 1000 and increasing, hence the importance of this book. - Summarizes our current understanding of Multiple Sclerosis - Discusses clinical features and available biomarker monitoring - Focuses on mechanisms that drive disease pathogenesis

Advances in Immunity volume 161 highlights new advances in the field, with this new volume presenting interesting chapters. Each chapter is written by an international board of authors. - Presents current developments and comprehensive reviews in immunology - Provides the latest in a longstanding and respected serial on the subject matter - Focuses on recent advances in immunology

Microbiome Nano-Cross-Talk presents a comprehensive overview of the functional aspects of multiphasic microbial and nanotechnological interactions within and between plants and their ecosystem. Recognizing that beneficial microbes are involved in plant growth promotion, this book highlights their mechanism and regulation to enhance plant's yield and development even under stressed conditions. The merging of nanotechnology with microbiology is an essential aspect of this book. Various nanomaterials, their synthesis approaches as well as applications in agriculture have been studied extensively in past years. However, there is still a lack of information available on the synergism between nanomaterials and microbes towards increased plant growth as well as reducing stress. Microbiome Nano-Cross-Talk, provides detailed insights into these environmental and agricultural perspectives of plant-microbe-nano interaction. With a focus on focus the morphological, anatomical, biochemical, molecular and gene expression levels of plant growth promotion, the book is the first of its kind to enable scientists to unravel the different pathways and signaling cascades involved in response to this interaction and to understanding how nanomaterials regulate the plant-microbe associations. It critically examines the role of beneficial microbes in conjunction with nanoparticles in plants and the mechanisms adopted by the plants at the biochemical and molecular levels to enhance plant growth and mitigate various stresses. - Presents a logistic approach to nanotechnology and microbiology in the plant sciences - Explores multiple nanomaterials and their interactions for improved plant health and yield - Enables the reader to devise strategies for engineering stress-tolerant plants and increased plant productivity

Biochemical Immunology of Diabetes and Associated Complications offers in-depth coverage of the association of biochemical and immunological aspects of the human body in diabetes. It discusses the suppression and modulation of the immune system and the impact of immunochemicals on the biochemical pathways in diabetes, and associated complications. It enumerates the exigency in knowledge about the immunomodulators as therapeutic targets to cure the syndrome. This book will serve as an important reference for medical practitioners, researchers, medical students, masters and doctoral students of life sciences background. It could also be used as a reference book for science graduates, science teachers and researchers from academia and industry. - Presents information on Immunosuppression and Immunomodulation that directly or indirectly affects the biochemistry underlying diabetes - Highlights the association of immunological and biochemical aspects in diabetes to gain a better understanding in handling the disease - Presents the latest research on inflammatory-mediated responses in the development of diabetes - Includes a chapter of Case studies related to the diseases in question

Beneficial Microbes for Sustainable Agriculture under Abiotic Stress: Funtional Traits and Regulation highlights the potential for microbe-mediated stress phytolerance to be improved by presenting multiple scenarios of application and results. In most research and studies, abiotic stress is applied singularly to specific plants inoculated with a bioinoculum or a bacterial consortium to isolate specific plant-microbe responses. However, in reality, plants are continually exposed to a multitude of different stresses simultaneously occurring. This book presents bacteria functional traits and bacteria-mediated plant responses under both specific or combined stress conditions. Collectively, it provides insights into bacterial functional traits and bacteria-mediated plant responses in a wide range of conditions, providing foundational understanding of their potential benefits, and inspiring further research. The book centers on specific bacterial strains and groups which have been shown to effectively promote stress tolerance, and which could be utilized to boost agricultural production under stress conditions. Their potential utilization in stress affected lands not just improves crop production but could also be in line with sustainable agriculture. With the advancement of tools such as Omics related technologies, emerging information on bacterial functional traits and regulations on bacteria mediated phytotolerance will also allow us to develop relevant biotechnologies harnessing potentials of plant-bacteria interactions under stress conditions. The information in this volume will be of interest to those working toward these next steps. - Includes microbial functional traits and responses common to all stresses, unique to specific stress and shared by multiple stresses - Focuses on microbial strains and groups proven to be most effective in promoting stress tolerance - Explores opportunities toward improvement of sustainable agriculture and resulting food security

Advances in Food and Nutrition Research, Volume 111 provides the latest on highly timely topics, including Understanding the Heterocyclic Aromatic Amine Research: An Overview and Recent Findings, Recent advances and challenges in the analysis of natural toxins, High Pressure Processing Plus Technologies: Enhancing the Inactivation of Vegetative Microorganisms, A discussion on A1-free milk: nuances and comments beyond implications to the health, Bioactive peptides as a novel strategy to prevent alcoholic liver injury, Hemp seed protein-derived short- and medium-chain peptides and their multifunctional properties, Condensed tannins – their content in plant foods, changes during processing, antioxidant and biological activities, and more. - Contains contributions that have been carefully selected based on the vast experience and expertise of the authors on the subject - Includes updated, in-depth, and critical discussions of available information, giving the reader a unique opportunity to learn - Encompasses a broad view of the topics at hand

Uncertainty in Computational Intelligence-Based Decision-Making focuses on techniques for reasoning and decision-making under uncertainty that are used to solve issues in artificial intelligence (AI). It covers a wide range of subjects, including knowledge acquisition and automated model construction, pattern recognition, machine learning, natural language processing, decision analysis, and decision support systems, among others. The first chapter of this book provides a thorough introduction to the topics of causation in Bayesian belief networks, applications of uncertainty, automated model construction and learning, graphic models for inference and decision making, and qualitative reasoning. The following chapters examine the fundamental models of computational techniques, computational modeling of biological and natural intelligent systems, including swarm intelligence, fuzzy systems, artificial neutral networks, artificial immune systems, and evolutionary computation. They also examine decision making and analysis, expert systems, and robotics in the context of artificial intelligence and computer science. - Provides readers a thorough understanding of the uncertainty that arises in artificial intelligence (AI), computational intelligence (CI) paradigms, and algorithms - Encourages readers to put concepts into practice and solve complex real-world problems using CI development frameworks like decision support systems and visual decision design - Provides a comprehensive overview of the techniques used in computational intelligence, uncertainty, and decision

Cyanobacteria, the ancient photoautotrophs on the Earth have always been regarded as the most important organism to sustain life in the planet. They are among the first pioneering communities on various harsh habitat, hydrarch or xerarch, which finally facilitate the emergence of vast communities including higher plants. Being the progenitor of chloroplast, the cyanobacterial metabolisms has always fascinated microbiologist. Additionally, the ability of these prokaryotes to produce valuable and prolific sources of natural products signified their role in array of industrial sectors. Further, the attempts to engineer the cyanobacterial metabolisms in way to enhance production of these metabolites are gradually increasing. Therefore, in this book, we proposed to accumulate the knowledge of cyanobacterial metabolisms and molecules as an asset for students, researchers, and biotechnologists. Cyanobacteria: Metabolisms to Molecules will cover diversity, fundamental metabolisms, crucial metabolities and their synthesis, and bioinformatics. - Casts light on cyanobacterial assistance and their potential role in sustainable developments - Provides significant insights into the fundamentals of cyanobacterial metabolism as well as lesser known topics - Determines the role of cyanobacteria in public health

Immunotoxicogenomics: A Multidisciplinary Approach in Systems Toxicology provides broad coverage to diverse aspects of immunotoxicogenomics. The book covers the major mechanisms and effects of toxic substances on the immune system and on the regulation of gene expression. This includes the aims, opportunities, clinical applications, recent developments, emerging and future trends in immunotoxicogenomics.The book starts off with a discussion of the systemic approach to the study of toxicants. It also looks at the current genomic tools used to assess immunotoxicity and the systems biology methods used in immuno-toxicogenomics. Other topics include genomic expression profiling, the use of gene expression as a tool to understand and predict immunotoxicity, immunotox-icogenomics as a screening tool, and the assessment and analysis of Immunotoxicogenomics data. Future trends round off the discussion in the book. Immunotoxicogenomics: A Multidisciplinary Approach in Systems Toxicology provides a collaborative multidisciplinary approach for researchers in the fields of toxicology, genetics, and immunology and others engaged in the study on the effects of toxic substances on immune responses. - Offers background and progress information for clinical applications and potential immunotoxicogenomics prospects - Covers the major mechanisms currently known by which toxic substances affect the immune system and gene expression - Provides a multidisciplinary approach to immunotoxicology, with updated content on fundamentals, the latest breakthroughs, clinical applications, and future perspectives

Artificial Intelligence for Drug Product Lifecycle Applications explains the use of artificial intelligence (AI) in drug discovery and development paths, including the clinical and postapproval phases. This book gives methods for each of the drug development steps, from the fundamentals to postapproval drug product. AI is a synergistic assembly of enhanced optimization strategies with particular applications in pharmaceutical development and advanced tools for promoting cost-effectiveness throughout the drug lifecycle. Specifically, AI brings together the potential to improve drug approval rates, reduce development costs, get medications to patients faster, and help patients comply with their treatments.Accelerated pharmaceutical development and drug product approval rates will enable larger profits from patent-protected market exclusivity. This book offers the tools and knowledge to create the right AI strategy to extend the landscape of AI applications across the drug lifecycle. It is especially useful for pharmaceutical scientists, health care professionals, and regulatory scientists, as well as advanced students and postgraduates actively involved in pharmaceutical product and process development involving the use of artificial intelligence in drug delivery applications. - Classifies AI methodologies and application examples into different categories representing the various steps of the drug development cycle - Combines timely literature review with clear artworks to improve understanding - Examines deep learning and machine learning in drug discovery

COVID-19 Management in the Brain and Body describes the management of patients with the novel coronavirus in their varied symptoms. Detailing this multisystem disease and the variety of organs and tissues affected, this volume features chapters on neurological systems, including brain cancer, brain embolism, and meningoencephalitis. Several systems are addressed, including conditions affecting hematological, hepatobiliary, gastrointestinal, and cardiovascular systems. Telemedicine and are also discussed. This volume is relevant for all clinicians working to ensure the best outcomes and patient care of patients with COVID-19. - Discusses the management of multisystem symptomatology, including the effects of COVID-19 on the neurological, respiratory, hematological, hepatobiliary, gastrointestinal, and cardiovascular systems - Includes select guidelines for clinics providing care for COVID-19 patients - Features individual chapter introductions, and a section on case studies to provide a comprehensive primer for each topic - Contains chapters with key facts, dictionary of terms, summary points, applications to other areas pertinent to each chapter, and policies and procedures

Microbial Biostimulants for Plant Growth, Development and Abiotic Stress Amelioration provides readers with insights into the major role of biostimulants in plant growth and development while under abiotic stress. The term biostimulants is broadly used to reference a group of diverse substances and microorganisms that stimulate life or that promote favorable plant responses. They stimulate natural processes to enhance/benefit nutrient uptake, nutrient efficiency, tolerance to abiotic stress, and crop quality. Many biostimulants improve nutrition and they do so regardless of their own nutrient contents. Further, recently microbe-based biostimulants have emerged as important plant protectors under a range of adverse conditions. Microbial Biostimulants for Plant Growth, Development and Abiotic Stress Amelioration is the latest volume in the Biostimulants and Protective Biochemical Agents series. - Presents the potential for more environmentally sustainable interventions against abiotic stresses - Highlights the variety of applications for which biostimulants are proving effective - Includes coverage of commercialization and role in addressing Sustainability Development Goals

Cooling Towers and Chilled Water Systems: Design, Operation, and Economic Analysis is a guide to the design and operation of cooling systems within high temperature settings. The book presents various strategies to increase the turndown of cooling towers and chilled water systems and provides a toolkit for engineers to determine the use of variable frequency drivers. A guide to equipment selection for optimal design during the detailed engineering phase is provided, ensuring the reader is able to comply with the project specification within budget. Sections discuss various systems, circuits and processes for cooling tower and chiller systems before detailing design principles. Operational and control strategies are then discussed before a thorough analysis of economic factors, making this book idea for professional engineers, graduate students and researchers working in high-temperature settings, such as power generation or chemical plants. - Presents strategies and tools for engineers to develop and manage efficient cooling towers and chilled water systems - Analyzes the economic benefits of cooled water system designs through the full lifecycle, instructing the reader on how to accurately estimate operating costs - Guides the reader through appropriate equipment selection to comply with project needs

Biomass Gasification, Pyrolysis, and Torrefaction: Practical Design, Theory, and Climate Change Mitigation, Fourth Edition explores the role of biomass conversion in climate change mitigation. With a focus on design, analysis and operational aspects of biomass gasification, pyrolysis and torrefaction, this edition offers comprehensive coverage of biomass in its gas, liquid and solid states. Processing and cleaning of product gas in gasification is considered, as are biomaterials and their development, making this a versatile resource that not only explains the basic principles of energy conversion systems, but also provides valuable insights into the design of a complete biomass conversion systems. For the first time, hydrogen production for fuel cells applications is addressed, reflecting the expanding role of hydrogen as a fuel source. Although the book carries the name'biomass', the bulk of its content is also applicable to non-biomass fuels like coal, petcoke, municipal solid waste and others. This book will allow professionals, such as engineers, scientists, and operating personnel of biomass gasification, pyrolysis or torrefaction plants, to gain a better comprehension of biomass conversion. - Features updates with the most recent research and technology - Includes a dedicated chapter on hydrogen production for fuel cell application - Explores the application of biomass conversion in climate change mitigation and sustainable development - Contains updated step-by-step process flow diagrams, design data, conversion charts and numerical examples with solutions - Provides available research results in an easy-to-use design methodology - Spotlights advanced processes such as supercritical water gasification and torrefaction of biomass - Examines the economic aspects of biomass conversion, including ecological economics and the circular economy for sustainable development

Transcription and Translation in Health and Disease provides a detailed overview of the regulators underlying transcription and translation in relation to a variety of human diseases and disorders. Beginning with an introduction into the current perspectives relating to these processes in human disease, the book expands to focus on specific mechanisms underlying conditions such as arthritis, cancer, neurological disorders, diabetes and cardiovascular disease. This book considers RNA processing and related mechanisms in eukaryotes including RNA splicing, RNA binding proteins, RNA interference, microRNAs, RNA editing, transcription factors, RNAi screening, CRISPR activation, CRISPR-Cas9 interference, and post-translational modifications. It provides a structured and detailed overview of the various regulators underlying molecular processes and their impact on health and disease, equipping readers with the necessary knowledge for further investigation in the areas of treatment and therapeutic intervention. - Discusses the role played by transcription and translational regulation in various diseases, including cancer, diabetes, cardiovascular disease and neurological disease - Considers a range of post-transcriptional regulators, including RNA-binding proteins, non-coding RNAs, epigenetic modifiers, alternative splicing and telomerase-binding proteins - Covers the topic from fundamental knowledge to the latest developments in clinical application - Includes a section dedicated to therapeutic applications

••Selected for Doody's Core Titles® 2024 in Microbiology••Understanding Microbial Biofilms: Fundamentals to Applications focuses on the microbial biofilms of different environments. The book provides a comprehensive overview of the fundamental aspects of microbial biofilms, their existence in nature, their significance, and the different clinical and environmental problems associated with them. The book covers both the fundamentals and applications of microbial biofilms, with chapters on the introduction to the microbial community and its architecture, physiology, mechanisms and imaging of biofilms in nature and fungal, algal, and bacillus biofilm control. In addition, the book highlights the molecular and biochemical aspects of bacterial biofilms, providing a compilation of chapters on the bacterial community and communication from different environments. Finally, the book covers recent advancements in various aspects of microbial biofilms including the chapters on their biotechnological applications. All the chapters are written by experts who have been working on different aspects of microbial biofilms. - Illustrates fundamental aspects surrounding microbial biofilms, along with recent advancements - Provides an overview on the principal aspects of biofilms, i.e., formation, regulation, distribution, control, and application - Updates on the progress on biofilm regulation through'omics'- Serves as a classical manual for all researchers, academicians, and students who would want complete insights on biofilms in a single resource - Covers all recent advancements and amendments on microbial biofilms

Plant Transcription Factors: Contribution in Development, Metabolism, and Environmental Stress provides comprehensive coverage of plant TFs and their various functions, evaluating their crucial role in growth and development, signaling, stress management and other key plant processes. Sections cover the significance of plant TFs in functional genomics, the influence of phyto-hormones on the modulation of plant TFs, plant development and metabolism, including shoot development, flowering development and alkaloid biosynthesis. The book's final section reviews the role of TFs in various plant stresses, including temperature, water and heavy metal stress. Written by leading experts around the globe, this book is an essential read to researchers interested in plant signaling and plant genomics. - Presents the latest advances in plant transcription factors and their functions - Discusses the influence of phyto-hormones on the modulation of plant transcription factors - Highlights the relationship between plant TFs and plant development

Energy storage plays an important role in supporting power-hungry devices and achieving stable power supply by optimally balancing supply and demand with ever-increasing requirement for computing power and the intermittent nature of renewable resources. Emerging Trends in Energy Storage Systems and Industrial Applications focuses on emerging trends in energy storage systems, applicable to various types of applications including heat and power generation, electrical and hybrid transportation. With performance limitations in current energy storage devices, such as limited energy density, power density, and cycle life, major challenges in the complex and dynamic environments of energy storage applications are examined in this reference. High-performance components, proper system configuration, effective modelling and control are keys to achieving seamlessly integrated and functional energy storage systems are also addressed, in order to provide guidance to achieving more reliable and efficient systems. Outcomes from this book serve as a resource for industrialists, academia and researchers working in the domain of advance energy storage technologies and their applications, giving them an overview of energy storage options, availability and technological trends enabling them to make longer-term, safe storage system decisions. - Presents a better understanding of the smart energy storage technologies: system, management, and implementation - Explores all energy storage system: integration, power quality, and operation - Offers an interdisciplinary look across electrical, electronics, energy, mechanical, civil, and chemical engineering aspects of energy storage

Profiles of Drug Substances, Excipients, and Related Methodology, Volume 48 encompasses review articles and database compilations that fall within one or more of the following five broad categories: Physical Profiles of Drug Substances and Excipients; Analytical Profiles of Drug Substances and Excipients; ADME Profiles of Drug Substances and Excipients; Methodology Related to the Characterization of Drug Substances and Excipients; Methods of Chemical Synthesis. There is no comparable book series that gives this crucial information in such a timely and relevant manner. The volume offers in-depth profiles of Brimonidine, Cristine, Remdesivir, Vandetanib, and Lapatinib. It also includes an additional chapter on Pharmaceutical-Based Cosmetic Serums. - Provides a comprehensive review of the physical, chemical and biological aspects of certain commonly prescribed medications - Includes nearly all analytical techniques utilized for drug substance identification and determination - Contains a cumulative index for easy access to information

Advances in Immunology, Volume 157, the latest release in a long-established and highly respected publication, presents current developments and comprehensive reviews in immunology. Chapters in this new release include Antigen receptor structure and signaling, T cells in the brain inflammation, The molecular mechanism of RIG-I/MDA5 activation and signaling, GSDMD biology, cGAS-STING pathway, The CARD8 inflammasome in HIV infection, and much more. - Presents current developments and comprehensive reviews in immunology - Provides the latest in a longstanding and respected serial on the subject matter - Focuses on recent advances in t cells and HIV infection

Diet and Nutrition in Neurological Disorders offers readers a comprehensive reference on the effect of dietary regimes in a wide variety of neurological diseases. With coverage of different types of diets, including Mediterranean or DASH, this broad coverage allows readers to learn about diets and their affect on specific disorders which may well be relevant to other conditions. This includes diseases such as Alzheimer's, Parkinson's, ALS, MS and severe neurological conditions such as brain injury, stroke, headache and migraine. This volume provides a platform for research on new dietary regimes and on future investigations of diet and nutrition. - Summarizes diet and nutrition research for a variety of neurological conditions - Contains chapter abstracts, key facts, dictionary and summary - Covers diet in Alzheimer's Parkinson's, ALS, MS, and more - Includes conditions like migraine, headache, stroke, and brain injury - Discusses the Mediterranean diet in the context of brain health

Nutraceutical Fruits and Foods for Neurodegenerative Disorders presents food-based strategies, specifically related to nutraceuticals, in delaying the onset and slowing down of the propensity of neuronal devastation. In addition to highlighting the positive effects of nutraceutical fruits and foods on brain health, the book also explores the medicinal properties of fruits, vegetables, berries and nutraceuticals, along with their contribution to environmental factors, potential hazards and the need for specific regulatory actions. This book will be a welcomed reference for nutrition researchers, dieticians, nutritionists and academicians studying related fields. - Presents the positive aspects of nutraceutical fruits and food effect on brain health - Highlights the structure activity relationship of constituents present in nutraceuticals in the treatment and cure of neurodegenerative diseases - Explores the nuances of novelty in dosage form design, production, authentication, quality control and market authorization of nutraceuticals

Handbook of Arsenic Toxicology, Second Edition presents the latest findings on arsenic, including its chemistry, sources and effects on the environment and human health. The book discusses both acute and chronic effects, discussing many aspects of arsenic, from physical and chemical properties, exposure, epidemiology, organ toxicity, diagnosis, prevention and treatment. Fully updated and revised, this new edition includes new topics on risk assessment, molecular mechanisms of arsenic, advances in the integrated approach to testing, assessment and development, evaluation and application of high content predictive models, and new alternative methods (NAMS) in the context of Adverse Outcome Pathways (AOPs) to assess toxicology. This comprehensive resource allows readers to effectively assess the risks related to arsenic, providing them with all they need to know on arsenic exposure, toxicity and toxicity prevention. - Brings together current findings on the effects of arsenic on the environment and human health - Includes state-of-the-art techniques in arsenic toxicokinetics, speciation and molecular mechanisms - Provides all the information needed for effective risk assessment, prevention and countermeasures

Inorganic Nanosystems: Theranostic Nanosystems, Volume Two examines the applications of nanotherapeutic systems and nanodiagnostics in relation to polymeric nanosystems. In the last decade, numerous biopolymers have been utilized to prepare polymeric nanosystems for therapeutic applications. These biopolymers include polylactic acid, polylactide-co-glycolide, polycaprolactone, acrylic polymers, cellulose and cellulose derivatives, alginates, chitosan, gellan gum, gelatin, albumin, chontroitin sulfate, hyaluronic acid, guar gum, gum Arabic, gum tragacanth, xanthan gum, and starches. Besides these biopolymers, grafted polymers are also being used as advanced polymeric materials to prepare many theranostic nanocarriers and nanoformulations. This book explores the array of polymeric nanosystems to understand therapeutic potentials. It will be useful to pharmaceutical scientists, including industrial pharmacists and analytical scientists, health care professionals, and regulatory scientists actively involved in the pharmaceutical product and process development of tailor-made polysaccharides in drug delivery applications. - Contains in-depth discussions of the inorganic nanosystems including high-quality graphics, flowcharts, and graphs for enhanced understanding - Reviews the literature on inorganic nanosystems while also suggesting new avenues - Includes contributions in all areas of inorganic nanosystems, providing a thorough and interdisciplinary work

Genetic Steroid Disorders, Second Edition targets adult and pediatric endocrinologists, clinical geneticists, genetic counselors, reproductive endocrinologists, neonatologists, urologists, and psychoendocrinologists. It is designed to assist these specialists in the diagnosis and treatment of steroid disorders. This revision includes a new chapter on'Gonadotropins, Obesity and Bone'and new research on non-invasive prenatal diagnosis with cell-free DNA. Chapters are thoroughly updated covering steroid disorders, the genetic bases for the disorder and case presentations, This definitive reference belongs in every medical library! - Presents a comprehensive, translational look at all aspects of genetic steroid disorders in one reference work - Provides a common language for endocrinologists, geneticists, molecular pathologists, and genetic counselors to discuss and diagnose genetic steroid disorders Saves clinicians and researchers time in quickly accessing the very latest details on genetic tests and diagnoses as opposed to searching through thousands of journal articles - Highlights significant discoveries with clinical relevance, presenting insight into which medications to use based on the genetic makeup of a patient - Teaches the best strategies and most effective use of genetic information in the patient counseling setting

Overexpression of receptor tyrosine kinases (RTKs) has been implicated in cancer. Increasing evidence suggests that dysregulation of RTKs is reported in many neurodegenerative and psychiatric disorders. Receptor Tyrosine Kinases in Neurodegenerative and Psychiatric Disorders provides a fundamental, pragmatic map of RTKs structure, activation, functions, mechanism of action, gene regulation, and signaling pathways in developing central nervous system (CNS), adult normal CNS, neurodegenerative and psychiatric disorders. Additionally, the structure, function, activation, and therapeutic potential of many growth factors have been covered. Here, international experts in the field offer a comprehensive discussion of results of pre-clinical and clinical studies of repositioning of anti-cancer receptor tyrosine kinase inhibitors (RTKIs) and other promising protein kinase inhibitors in various neurodegenerative disorders including, Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, Huntington's disease, and multiple sclerosis, and psychiatric disorders including, anxiety, depression, alcohol use disorder, and schizophrenia. In addition, the book discusses the obstacles and opportunities for the potential repositioning of kinase inhibitors in neurodegenerative and psychiatric disorders. - Provides a thorough overview of RTKs biology and their role in health and disease progression and modulation - Highlights RTK families and the numerous receptors within each subfamily - Examines RTKIs and other protein kinase inhibitors in pre-clinical and clinical trials in both neurodegenerative and psychiatric disorders - Gives future directions of possible safe effective targeted RTKIs and other protein kinase inhibitors that may be repositioned in various neurodegenerative and psychiatric disorders - Includes chapter contributions from renowned experts in biology, pharmacology, neurology, psychiatry, and oncology

The Liver Graft Before Transplantation: Defining Outcome After Liver Transplantation provides a comprehensive overview of pre-transplant assessment and conditioning of liver grafts to guide the best strategy for successful transplantation for better outcomes for patients. Sections provide an overview of the history and indications for liver transplantations as well as coverage of current practices used in transplantation. Next donor and liver graft assessment are discussed with specific coverage of diseases that carry a risk of recurrence after liver transplantation, including hepatocellular carcinoma, NASH, primary biliary cholangitis, primary sclerosing cholangitis, and viral hepatitis.Finally, the impact of the use of suboptimal liver grafts and clues to make the right trade-of between benefit and risk are discussed. This is the perfect reference for clinicians who need a comprehensive, clinically relevant overview of pre-transplant assessment and conditioning of liver grafts and want to know what to expect in future years. - Provides a comprehensive overview of pretransplant assessment and conditioning of liver grafts in one reference - Provides the latest information in the rapidly evolving field of machine perfusion - Includes expert opinions that help readers understand and anticipate issues to be addressed regarding the donor and the allograft before transplantation

Living Organ Donor Transplantation, Second Edition puts the entire discipline in perspective while guiding readers step-by-step through the most common organ transplant surgeries. Organized into four cohesive parts and featuring numerous surgical illustrations, this sourcebook delivers an incisive look at every key consideration for general surgeons who perform transplantations, from patient selection to recipient workup and outcomes, and emphasizes the most humanitarian approaches. Sections provide content on living donor uterus transplantation, new operative techniques, including the use of robotic and minimally invasive transplant procedures, new immunosuppressive regimens, new protocols of tolerance induction including stem cell therapy and transplantation, and much more.Chapter authors are international leaders in their fields and represent institutions from four continents (Americas: USA, Argentina, Brazil, Canada; Europe: France, Germany, Italy, Spain, Sweden, UK; Asia: China, Japan, Korea, Taiwan; Australia). - Provides an A-Z, operation-oriented guide to the field of living donor organ transplantation - Examines a wide spectrum of solid organ transplantation procedures (liver, pancreas, kidney, intestine), with accompanying chapters on the history of the procedure, the donor, the recipient, and cost analysis - Covers techniques that explain adequate pretransplant workup and posttransplant care - Covers cultural differences, ethical and legal issues, social issues, current financial incentives, and the illegal organ trade

Advances in Stem Cells and their Niches, Volume Seven highlights new advances in the field, with this new volume presenting interesting chapters written by an international board of authors. - Provides the authority and expertise of leading contributors from an international board of authors - Presents the latest release in the Advances in Stem Cells and their Niches series

Neglected and Underutilized Crops: Future Smart Food explores future food crops with climate resilience potential. Sections cover their botany, nutritional significance, global distribution, production technology, and tolerance to biotic and abiotic stresses of neglected and underutilized crops. By simply changing species in a crop rotation system, the cycle of some pests and diseases is disrupted and probabilities of infestations are reduced. Finally, the book provides case studies that highlight where the adaptation of crops to local environments, especially with regard to climate change, have been successful.These crops can help make agricultural production systems more resilient to climate change. Although a few books on neglected and underutilized crops are available, this comprehensive book covers the full scope of crop husbandry, nutritional significance and global distribution. - Contains consistent coverage of botany, nutritional significance, production technology, and tolerance to biotic and abiotic stresses - Presents case studies of success stories where adaptations in local environments have made a difference, especially with climate change - Addresses key opportunities for improving global food security

Colorectal Cancer: Disease and Advanced Drug Delivery Strategies examines the combined impact of basic clinical and medical treatments as well as recent advances in the field of colorectal cancer.With a strong focus towards colorectal cancer diagnosis, disease drug delivery, and diagnosis, the book also examines the Tumor microenvironment-responsive and site-specific nanoparticles for cancer theragnostics.In 16 chapters Colorectal Cancer: Disease and Advanced Drug Delivery Strategies not only provides the opportunity to understand and diagnose the disease, but it also describes screening methods, drugs including nano- and immunotherapy, and gives insight into the role of nanoparticles, lipids, and biomarkers in colorectal cancer. Content includes clinical trials in colorectal cancer research and disease models. This book directs researchers and clinicians how to better diagnose and treat colorectal cancer.Provides a wealth of information on the latest research and developments in the science and treatment of colorectal cancerContains new and innovative ways to treat colorectal cancerReflects on basic clinical and medical methods and recent advances in colorectal cancer scienceGives specific details about how nanoparticles can be used to target cancer cells or cancer treatmentCovers tumor microenvironment, their challenges, and opportunities in colorectal cancer research

Encyclopedia of Cell Biology, Second Edition, a Six Volume Set, has established itself as a fundamental reference work, providing broad coverage of the field in four main sections (Molecular, Organizational, Functional, Translational and Pathological Aspects of Cell Biology). This second edition revisits and expands each section, with entries on topics not covered in the first edition, including Crispr. The whole work is updated, providing greater coverage of specialized cell function and translational applications, and putting greater emphasis on these topics in graduate/medical teaching. New overview chapters and subsections provide a simplified cell biology text that can be used by instructors. The new version includes a standard template for each chapter, making the content easier to navigate, as well as inserts and graphics which provide summaries of key points in each chapter. - Provides the authority of a team of outstanding scientists in the field - Presents a comprehensive, up-to-date resource, covering both basic and translational aspects of cell biology - Offers high quality content at a competitive market price

Biochemical Pathways and Environmental Responses in Plants, Part A, Volume 676 in the Methods in Enzymology series highlights new advances in the field with this new volume presenting interesting chapters on topics such as Structure, function, and engineering of plant polyketide synthases, A sensitive LC-MS/MS assay for enzymatic characterization of methylthioalkylmalate synthase involved in glucosinolate side-chain elongation, Assaying formate-tetrahydrofolate ligase with monoglutamylated and polyglutamylated substrates using a fluorescence-HPLC based assay, An Approach to Nearest Neighbor Analysis of Pigmented Protein Complexes by Using Chemical Crosslinking in Combination with Mass Spectrometry, and much more. Other chapters cover Biochemical characterization of plant aromatic aminotransferases, Functional Analysis of Phosphoethanolamine N-methyltransferase (PMT) in Plants and Parasites, A structure-guided computational screening approach for predicting plant enzyme-metabolite interactions, Plant metacaspase: an example of microcrystal structure determination and analysis, Biocatalytic system for comparative assessment of functional association of cytochrome P450 monooxygenases with their redox partners, Dirigent Protein Family Function and Structure, and more. - Provides the authority and expertise of leading contributors from an international board of authors - Presents the latest release in Methods in Enzymology series - Includes the latest information on Biochemical pathways and environmental responses in plants

Applications of Essential Oils in the Food Industry delivers detailed information on the application of essential oils derived from underutilized crops and herbs for the development, preservation, and safety of food products. The book covers post-harvest fruits and vegetables and their adjuvant and plasticizers when applied as an edible coating, as well as their mechanism of action as preservatives for foods, such as fish, meats, and yogurts. The book highlights the use of essential oils as anti-microbials, bio-preservatives, and antioxidants, and also examines their effectiveness against several food borne pathogens and in enhancing the aroma of food products. Presents the latest research information on essential oils as anti-microbials, bio-preservatives, and antioxidants Describes how essential oils can be used for the management of mycotoxins, especially for the management of toxigenic strains producing higher level of aflatoxin Includes information on the utilization of essential oils in beverages, drinks and semi liquid foods Demonstrates the synergetic effect of nanotechnology together with essential oils, including information on nano-ceutical, nano-emulsion, and nano-pharmacology

Unravelling Plant-Microbe Synergy focuses on agriculturally important microorganisms (AIM's) that are indigenous to soil and roots of the plant. These microbes contributing to nutrient balance, growth regulators, suppressing pathogens, alleviate stress response, orchestrating immune response and improving crop performance as they are offering sustainable and alternative solutions to the use of chemicals in agriculture. As plant microbe synergy is an enthralling subject, is multidisciplinary in nature, and concerns scientists involved in applied, and environmental microbiology and plant health and plant protection, Unravelling Plant-Microbe Synergy is an ideal resource that emphasizes the current trends of, and probable future of, microbes mediated amelioration of abiotic and biotic stress, agriculture sustainability, induced systemic tolerance and plant health protection. Unravelling Plant-Microbe Synergy discloses the microbial interaction for stress management and provides a better understanding to know the recent mechanisms to cope these environmental stresses. Unravelling Plant-Microbe Synergy bridges the gap in recent advances in the microbes interaction and rhizosphere engineering. - Emphasizes the plant microbes interactions, induced systemic tolerance, stress responsive genes and diversity of microorganisms - Illustrates the current impact of climate change on plant productivity along with mitigation strategies - Provides a two-way interactive approach to both plants and microbes, and includes multi-omics approaches

Antimicrobial Dressings: The Wound Care Applications explores the literature surrounding the catalytic behavior of proteolytic enzymes immobilized together with nanoparticles. As numerous applications using proteolytic enzymes for debridement, silver as antibiotic and nanoparticles for enzyme immobilization were developed in the last years, this book explores interdisciplinary information combining nanotechnology, biotechnology and medicine and how it's still in early stages. The book adopts a holistic approach in a lifecycle context to evaluate their final feasibility, including industrial exploitability without disregard of the potential risks of enzymes and nanomaterials to human health and the environment. - Describes the drawback of using unstable enzymes in wound debridement such as infections, irritations, low availability, rapid elimination from the body, and impossibility of creating a high local concentration of the preparation without increasing its systemic concentration - Provides information on higher efficient antimicrobial property and enzyme stability using nanoparticles as carriers for enzyme immobilization due to minimum diffusional limitation, maximum surface area per unit mass, and high enzyme loading - Discusses the physical characteristics of the nanoparticles through multilayer polyelectrolytes encasing, such as diffusion and particle mobility that will influence the catalytic activity, pH and thermal stability of attached enzymes

Material-Microbes Interactions: Environmental Biotechnological Perspective brings great insights into microbes-material interactions, biofilm formation and emerging bioprocesses within the field of applied biotechnology. The book systematically summarizes the fundamental principles, the state-of-the-art in microbes-material interaction, and its application in bioprocess and environmental technology development. Understanding the fundamental processes of biofilm formation, the role of material to exchange the energy with microbes, biofilm matrix, and optimization of the biofilm formation process is useful to everyone involved with bioprocess development. This book will be of significant interest to environmental technology developers, researchers, university professors, policymakers, graduate and postgraduate students and other stakeholders. Interestingly, academic institutions, wastewater treatment plants and research centers have upscaled biofilm-based environmental technologies, such as moving bed bioreactors, microalgae, tricking bed reactors, biofilters, and bioelectrochemical process as promising environmental technologies. - Illustrates growing interest in biofilm-based technology development, either wastewater treatment using carrier materials or valorizing waste material into resources using biofilm-based bioprocess - Focuses explicitly on the microbes-material interactions in various biotechnologies - Covers a broad range of biofilm-based bioprocesses, including new and state-of-the-art options and trends within the field - Includes photo-sets on biofilm development and bioreactor systems

Applications of Nanovesicular Drug Delivery provides thorough insights and a complete and updated discussion on the preparation, properties and drug delivery applications of various nanovesicles. This volume will discuss target-specific drug application, such as ocular, transdermal, nasal, intravenous and oral delivery. This title is a valuable resource for academics, pharmaceutical scientists, including industrial pharmacists and analytical scientists, health care professionals and regulatory scientists actively involved in pharmaceutical products and process development of tailored-made polysaccharides in drug delivery applications. Recently, there have been a number of outstanding nanosystems in nanovesicular carrier-forms (such as nanoemulsions, self-nanoemulsifying systems, nanoliposomes, nanotransferosomes, etc.), that have been researched and developed for efficient drug delivery by many formulators, researchers and scientists. However, no previously published books have covered all these drug delivery nanovesicles collectively in a single resource. - Provides thorough insights and up-to-date discussions about the various systems of nanovesicular drug delivery - Covers advanced trigger-assisted systems (such as iontophoresis, ultra-sound triggering, etc.) and how they have been used for improved drug delivery by nanovesicles - Presents recent advances in drug delivery fields by global leaders and experts from academia, research, industry and regulatory agencies - Includes an updated literature review of relevant key topics, good quality illustrations, chemical structures, attractive flow charts and well-organized tables

Trends of Applied Microbiology for a Sustainable Economy discusses the role of modern tools and next-generation technologies in applied microbial research, including recent trends and innovation in global biofertilizers. Agriculture has seen dramatic changes since the time of its inception. Starting with the domestication of wild plants to small-scale traditional farming and then large-scale, chemical-intensive agriculture. It is at a crossroads once again, putting a huge amount of pressure on available natural resources like soil, water and biodiversity which is bound to increase with the ever-growing human population. This book helps readers understand the challenges associated with these demographic changes. - Redefines the relationship between microorganisms and agricultural sustainability in view of the latest technologies and advancements - Documents recent microbiological advancements in agricultural research and discusses challenges and opportunities in the biofertilizers market - Identifies challenges and opportunities for scaling up biofertilizers technology - Discusses recent trends and innovations in the biotechnology market and economy

Combination Drug Delivery Approach as an Effective Therapy for Various Diseases explores the use of bioengineering tools in combination drug delivery approaches to control various diseases at different clinical stages of synergistic action, varying mechanisms of action, and during the suppression of drug resistance. The book presents fundamental knowledge on the experiential and experimental aspects of drug combination approaches in order to equip rational applications in preventing the emergence of resistance during the treatment of various diseases. It provides a holistic understanding of the principles behind formation, characterization, applications, regulations, toxicity, challenges and future perspectives of combination drug delivery approaches. It will be of interest to researchers and advanced graduate students in pharmaceutical science, chemistry, biology and medicine, as well as pharmaceutical companies and scientific organizations. - Provides an accounting of vital aspects on various combination drug delivery approaches, presenting next generation diagnostics and therapeutics - Discusses the perspectives of current technologies in highly organized tables, illustrative figures and flow charts - Defines major gaps in knowledge that can lead to significant scientific discoveries

Rhizosphere Engineering is a guide to applying environmentally sound agronomic practices to improve crop yield while also protecting soil resources. Focusing on the potential and positive impacts of appropriate practices, the book includes the use of beneficial microbes, nanotechnology and metagenomics. Developing and applying techniques that not only enhance yield, but also restore the quality of soil and water using beneficial microbes such as Bacillus, Pseudomonas, vesicular-arbuscular mycorrhiza (VAM) fungi and others are covered, along with new information on utilizing nanotechnology, quorum sensing and other technologies to further advance the science. Designed to fill the gap between research and application, this book is written for advanced students, researchers and those seeking real-world insights for improving agricultural production. - Explores the potential benefits of optimized rhizosphere - Includes metagenomics and their emerging importance - Presents insights into the use of biosurfactants