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Hallucinogens have been traditionally used to encourage spiritual growth, heighten perception, inspire personal development, or expand reality. Comprehensive Guide to Hallucinogenic Plants focuses on ethnobotanical aspects of hallucinogenic plant species, featuring history on how they were used in ancient societies, identifying chemical compounds, and explaining modern medicinal uses, as well as conservation initiatives. The book emphasizes the importance of understanding the cultural, countrywide, environmental, and scientific importance of these medicinal plants.Some of the 50 plants covered in this work include: ayahuasca, ginger, kanna, dream herb, iboga, peyote, canary broom, coral tree, catnip, wild rue, kava, mandrake, and golden angel's trumpet. Each chapter includes information on historical plant use and identification of chemical compounds, and explains modern medicinal uses. The text highlights the importance of studying, evaluating, and utilizing these plants not in isolation, but from a global perspective.A volume in the Exploring Medicinal Plants series, Comprehensive Guide to Hallucinogenic Plants appeals to plant scientists, botanists, ethnobotanists, pharmacologists, and those with an interest in alternative or herbal medicine.

This book aims to engage “Young Science – Talented & Ambitious” for a lasting collaboration to advance holistic mathematical modeling of “how the body works” in variant surroundings. The book sets road signs to mathematics in body's vital, physical, and cognitive functions, as well as to factors of health impact in person's environmental and social settings. It showcases selected current research in mathematical and biological theory, mathematical models at molecular, organism, and population levels as well as engineering, imaging, and data sciences methodologies, including bio-informatics and machine learning applications. For overarching theory, evaluation of surrogate structures with category theory, multi-scale whole-body dynamics by separation of functional organization from cellular material as well as mathematical axioms matching classic principles of philosophy in traditional Chinese medicine are introduced. Interested are systems-oriented researchers in all sciences related to human health who seek new profile-shaping challenges in transdisciplinary collaboration.

Harness sustainable, environmentally friendly chemical processes with this timely volume Green chemistry has played a leading role in the broader search for environmentally sustainable industry. One of its most important goals is the shift from volatile, hazardous organic solvents to environmentally friendly ones, of which by far the most promising is water. Cultivating organic transformations using water as a solvent is one of the most crucial steps towards the creation of green, sustainable chemical production processes. Organic Transformations in Water provides a cutting-edge overview of water as a reaction medium for synthesis and catalysis. After a brief introduction, the book moves through each of the most important classes of organic transformation before concluding with a survey of industrial applications. The book will also cover: Chemistry and physicochemical aspects of “on-water” and “in-water” reactionsC–H activation, metathesis, nucleophilic addition and substitution, oxidation and reduction, and many moreAsymmetric organic reactions in waterApplications in organocatalysis, electrocatalysis, and photocatalysis Timely and comprehensive, Organic Transformations in Water is a must-own volume for researchers and industry professionals looking to revolutionize their work in a sustainable way.

Proteomics, Multi-Omics and Systems Biology in Optic Nerve Regeneration is a comprehensive reference that covers all vistas of standardization of axon regeneration, as well as all multi-omics and system level data and integration tools. By adopting a translational approach, the book bridges current research in the field to clinical applications, and readers can expect to learn standardization approaches for axon regeneration, multi-omics datasets, different databases, search engines, multiple dataset integrative tools, pathway convergence approaches and tools, outcome and outcome measures that unify bench research with clinical outcome.The axon regeneration from existing neurons in central nervous system (CNS) have become a potential possibility in the last decade. The potential possibility of long-distance axon growth has opened the possibility of re-connectivity of axons of retinal ganglion cell neurons within the lateral geniculate nucleus in the brain. The long-distance axon regeneration and re-connectivity is a promise to restore lost vision in the optic nerve. Further, long-distance regeneration and re-innervation is equally helpful for other fields such as spinal cord injuries. - Includes updates on the use of multi-omics datasets for selecting molecules for axon regeneration - Bridges the preclinical and clinical world, from selection of the molecules to outcome leading to IND filing and their use - Includes system level knowledge needed for central nervous system axon and dendrite regeneration, and standardizes the system level biology for axon regeneration - Explores the current state of multi-omics in axon and dendrite regeneration in the optic nerve and its comparison to other CNS regeneration

This book provides the reader with a thorough understanding of the science of addiction, as well as practical tools for diagnosing, treating, and supporting individuals with alcohol use disorder. It also offers guidance for building a successful recovery and preventing relapse, and it serves as a comprehensive and evidence-based resource that brings together the latest scientific research and guidelines endorsed by expert professionals. Alcohol use disorder is a prevalent and complex disease that affects millions of people worldwide, yet is often misunderstood and stigmatized. This book is intended to contribute to reducing the stigma and misconceptions surrounding the disease and promoting access to evidence-based treatment and support. This volume is structured in a way that allows readers to move through the content in a logical and accessible manner. The first few chapters provide an overview of alcohol use disorder, its historical and cultural context, and the science of addiction. Following that, authors delve into the various causes and risk factors for alcohol use disorder, signs and symptoms, diagnosis and screening tools, and co-occurring mental health conditions. The treatment options for alcohol use disorder are covered in depth, including medication-assisted treatment, behavioral therapies, and support systems for recovery. Chapters explore ways to prevent relapse and build a successful life in recovery. Additionally, the subject of stigma and misconceptions surrounding addictions such as alcohol use disorder is discussed, as are the barriers in building greater awareness, understanding, and access to care. A chapter on advocacy and policy aims to identify and highlight various paths taken in improving access to treatment and recovery support services, and the book closes with a chapter on all the major research and promising treatments that are currently underway. From Stigma to Support: A New Vision for Alcohol Use Disorder Treatment and Recovery is a comprehensive and practical guide that will be greatly valued by psychiatrists and any other medical provider that might treat patients with alcohol use disorder.

Viruses, bacteria, fungi and parasites are known to cause the most common human disease. It frequently spreads through direct contact (from human to human, animal to human), and through contaminated food or water. With the advancement of diagnostic techniques, it is now possible to rapidly identify microorganisms causing human disease and correlate with the corresponding clinical infection. Therefore, there is a need to develop robust and high-throughput diagnostic methods to prevent and control human disease of public health importance. This book entitled “Recent Advancements in the Diagnosis of Human Disease” will help the scientific community to better understand the transmission dynamics of some human diseases.

The Hidden World of Protein Aggregation, Volume 206 provides a comprehensive exploration of protein aggregation, uncovering the factors behind the formation of amorphous aggregates and ordered structures called amyloid fibrils. It delves into the advantages and disadvantages of protein aggregates, addressing topics such as cytotoxicity and disorders linked to misfolding. Specific chapters in this release include Protein Aggregation: An Overview, Pathways of Amyloid Fibril Formation and Aggregation, Factors Influencing Amyloid Fibril Formation, Morphological Features and Types of Aggregated Structures, Each big journey starts with a first step: Importance of Oligomerization, Liquid-Liquid Phase Separation as Triggering Factor of Fibril Formation, and more.Additional sections cover Experimental Techniques for Detecting and Evaluating the Amyloid Fibrils, Prediction of Protein Aggregation, Amyloid Fibril Cytotoxicity and Associated Disorders, Inhibitors of Amyloid Fibril Formation, Therapeutic Approaches in Proteinopathies, Functional Amyloids, Biotechnological Applications of Amyloid Fibrils, and The Hidden World of Protein Aggregation. - Provides an introduction to the folding of protein and associated conditions leading to aggregation and linked pathology - Discusses structural biology and computational methodologies for analysis of protein (mis)folding and aggregation - Describes functional amyloids and their biotechnological applications

Advances in Host Genetics and Microbiome in Lifestyle-Related Phenotypes, Volume 111 explores the recent discoveries in the interaction between Host Genetics-Microbiome and lifestyle-related phenotypes regarding precision nutrition, physical activity, sports performance, circadian rhythm, sleep, and rest. Chapters in this release include Techniques, procedures, and applications in host Genetic analysis, Techniques, procedures, and applications in Microbiome analysis, Human adaptations to diet: biological and cultural coevolution, Impact of Evolution on Lifestyle in Microbiome, Nutrition and host Genetics: nutrigenetics, Nutrition and Microbiome: microbiome nutrition, Genomic predictors of physical activity and athletic performance, physical activity and Microbiome, Microbiome and Host Genetics in Circadian Rhythm, and more. - Explores Host Genetics and Microbiome in Nutrition - Delves into nutrition, physical activity, sports performance, circadian rhythm, sleep, and rest - Covers the impact of evolution on lifestyle

Comprehensive yet succinct insight into the prevention, diagnosis, and treatment of infectious diseases including COVID-19, mpox, Ebola, and Lyme disease Rising Contagious Diseases provides basic information about preventing and treating threatening infectious diseases from viral, bacterial, and parasitic sources, including 28 emerging or recurring diseases like COVID-19, mpox, Ebola, bird and swine flu, malaria, Legionnaires', and others. The text highlights molecular surveillance and epidemiology (including zoonotic pathogens or their variants), innovative strategies for pathogen detection, drug and vaccine development, appropriate preventive measures, cost-effective diagnostic procedures (assays), and effective therapeutic strategies. The text is unique due to its broad coverage of today's infectious diseases, covering several which are not similarly addressed elsewhere, with detailed insight from experts around the world. Composed of 30 chapters of fundamental facts alongside practical and clinical data, Rising Contagious Diseases covers sample topics such as: Re-emergence of certain diseases in recent decades due to dynamic host-pathogen interactions, anthropogenic selection, and climate change How real-time epidemiological surveillance can improve detection of infectious disease outbreaks or new infections of public health importance Up-to-date insight on transmission dynamics, epidemiology, clinical manifestation, advances in diagnostics, and management of covered diseases Effects of disease outbreaks on the world at large, such as through high morbidity and mortality rates and rising healthcare costs With detailed insight on the prevention, diagnosis, and treatment of infectious diseases, Rising Contagious Diseases is an essential reference for health care professionals, academics in the field of microbiology, immunology, infectious diseases, pathology, pharmacology and public health, and undergraduates and postgraduates in related disciplines.

The Sixth Edition of Charney and Nestler's Neurobiology of Mental Illness builds on previous editions of the book and reflects the continuing progress in reintegrating psychiatry into the mainstream of modern biomedical science. This reintegration remains a work in progress, based on the unique complexity of the brain and its diseases. Yet, the research tools that are transforming other branches of medicine-epidemiology, genetics, epigenetics, molecular and cell biology, imaging, and medicinal chemistry, along with fundamental advances in the neurosciences that make it possible to decipher cell types and their larger circuits to an unprecedented degree, are now at long last transforming psychiatry. Collectively, the 75 chapters in this newly renovated textbook describe the developments in genetics and in molecular, cellular, and systems neuroscience that are breaking new ground in the diagnosis, treatment, and prevention of disabling psychiatric disorders. In this updated edition, Section 1 focuses on the major methodological approaches to studying the biological basis of mental illness. Sections 2 through 8 each focus on a major class of mental illness, including schizophrenia, bipolar disorder, depression, anxiety and trauma disorders, substance use disorders, neurodegenerative disorders, and childhood psychiatry disorders. The final section is a collection of essays that address what can be expected over the next decade in terms of improving psychiatric diagnosis, achieving a true precision approach to treating mental illness, along with new avenues of medication and non-medication therapies in the offing.

There has been an enormous growth of interest in the field of toxicologic pathology and particularly on its impact on nonclinical safety assessment in global drug development and in the environment. Toxicologic pathologists play an important role in detecting test article-related adverse effects by characterizing morphologic changes in animal tissues and/or body fluids under prescribed study conditions or less clearly defined conditions in the environment and in the interpretation of these findings relative to human risk. In fact, pathology evaluation is often the single most important decision-making factor in nonclinical safety assessments as 80% of drug candidate attrition has been attributed to pathology findings in toxicity studies. There are currently no primers or basic overviews covering the field of toxicologic pathology, whereas there are at least several basic books that cover the sister field of toxicology.Toxicologic Pathology: A Primer is a practical, easy-to-use reference designed to contain core information provided by board-certified veterinary pathologists, all experts in the field. The Primer contains the basic, underlying principles of toxicologic pathology at the introductory level; thus it will be valuable to the veterinary pathology student who may be considering a career in the field as well as a companion to the seasoned toxicologic pathologist who wants a succinct refresher. The Primer is arranged as chapters presenting each major organ system preceded by an overview chapter covering the field of toxicologic pathology followed by a “concept” chapter describing the role of toxicologic pathology in drug development. Photomicrographs and illustrations provide visual context.The organ system chapters provide histopathologic descriptions of lesions observed in toxicity studies of test articles in drug development and testing of chemicals that may negatively impact the environment. Each organ system chapter provides additional information related to a particular lesion to aid the reader in better understanding its toxicologic significance relative to human risk.Each organ system chapter contains: A brief introduction A succinct description of the anatomy and physiology of the system Descriptions of the most important pathological lesions Differential diagnoses Biological consequences, pathogenesis, and/or mechanism of lesion formation Associated clinical pathology correlates Nonclinical safety scientists such as study directors, non-pathology-oriented contributing scientists such as senior toxicology report reviewers, scientific management of Contract Research Organizations (CROs), and students should find the Primer useful in helping them understand the fundamentals of toxicologic pathology.

Comprehensive Chirality, Second Edition is the definitive ten-volume reference, offering a thorough exploration of chiral research and application. This extensively updated edition features 121 new chapters and 70 revised ones, focusing on the latest advancements in chiral research across synthesis, catalysis, analytical chemistry, and bioactive compound synthesis. Edited by a world-class editorial board, with contributions from leading experts, Comprehensive Chirality, Second Edition bridges theoretical principles with practical applications, making it an invaluable resource for advanced students, researchers, and professionals. Key highlights include:- Innovative Reactions and Methods: advanced diastereo- and enantioselective techniques for controlling stereogenic centers in complex natural products and pharmaceuticals.- Chiral Auxiliaries and Modern Reagents: transformative uses of chiral auxiliaries and cutting-edge reagents such as hypervalent iodide.- Catalytic Methodologies: comprehensive coverage of C-C bond formation, emphasizing transition metals, biocatalysis, and multicatalysis.- Asymmetric Photochemistry: light-induced asymmetric transformations.- Olefin Functionalization and Cycloaddition: asymmetric oxidation and reduction methods.- Biocatalysis and Enzyme Engineering: in-depth analysis of enzyme design and engineering as powerful synthesis catalysts.- Industrial Applications: practical insights into asymmetric synthesis for industrial applications, illustrated through recent case studies.- Spectroscopic Techniques: updated spectroscopic methods for separating and analyzing enantiomers. - Unites different areas of research and allows anyone working or researching in chiral chemistry to navigate through the most essential concepts - Includes different areas of research and deep foundational reviews - Helps users apply context to diverse journal literature, aiding them in identifying areas for further research and/or for solving problems - Serves as a valuable, critical tool for instructors, practicing experimentalists, and students of the field, as well as those curious to gain appreciation of the chirality landscape and its vast expanse

Long known to be important for memory, the hippocampus has been a prime focus for neuroscience research for years. This second edition of The Hippocampus Book highlights advances in our understanding of this group of brain structures and includes a new set of translational chapters concerning associated brain disorders. This edition brings together contributions by leading international experts on hippocampal anatomy, physiology, molecular biology and function with other chapters summarizing how disorders of hippocampal function contribute to several neurologic and psychiatric conditions. Concurrently, this text illustrates how research focusing on this single brain structure has revealed principles of wider generality for the whole brain in relation to anatomical connectivity, neural and synaptic plasticity, cognition and behaviour, and computational algorithms. Covering theory, experimental data and translational relevance, this uniquely authoritative work vividly illustrates the progress that continues to be made in unravelling the workings of the brain. The Hippocampus Book will be of interest to those working in a range of neuroscientific disciplines, ranging from the molecular biology of neural function and dysfunction, through network physiology to behavior and neuropathology and take pride of place on the bookshelves of all with an interest in the brain and its functions.

Authored by over 500 internationally acclaimed expert editors and chapter authors from around the world. Completely updated and expanded with almost 40 new chapters. Significantly increased attention to the role of culture in all aspects of evaluation and care. New sections on Digital Mental Health Services and Technologies, Treatment Issues in Specific Populations and Settings, and on Prevention, Systems of Care, and Psychosocial Aspects of Treatment address key advances. This edition is the first comprehensive reference work to cover the entire field of psychiatry in an updateable format, ensuring access to state of the art information. Earlier editions were called “the best current textbook of psychiatry” by the New England Journal of Medicine, and “the gold standard” by the American Journal of Psychiatry. Tasman's Psychiatry, 5th Edition, builds on the initial vision in prior editions of approaching psychiatric evaluation and care from an integrative bio-psycho-social-cultural perspective. It is designed to be an essential and accessible reference for readers at any level of experience. This editorial approach encompasses the importance of the first encounter between patient and clinician, followed by the complex task of beginning to develop a therapeutic relationship and to develop and implement a treatment plan in collaboration with the patient. The importance of increasing attention to the role of culture and social determinants of mental health is reflected both in specific chapters and in components of many chapters throughout the book, especially in those pertaining to clinical evaluation, the therapeutic alliance, and treatment. The global scope of this edition is reflected throughout the book, including the section on psychiatric disorders where evaluation using both ICD 11 and DSM 5-TR is discussed. Most chapters are authored by experts from at least two different countries or continents, adding a critically important dimension which often is missing in major psychiatric textbooks. Tasman's Psychiatry, 5th Edition, is an essential reference for all medical professionals and students who need a trusted reference or learning tool for psychiatry, psychology, clinical research, social work, counseling, therapy, and all others.

This volume includes nine chapters that detail advances in health and disease. In chapter one the authors review proteins and transcription factors involved in the process of EMT and analyze the potential of proved or non-proved phytodrug to inhibit resistance to conventional therapies and /or metastasis, emphasizing their specificity. Chapter two provides an overview of the knowledge gained so far concerning the role of different members of phosphodiesterases subfamilies under physiological, as well as pathological conditions. In chapter three the authors discuss the involvement of IL-9 and Th9 cells in various cancers, highlighting their role in cancer immunity. The authors in chapter four identifiy the prospects for using drugs with anticonvulsant action that primarily restricts neuronal excitation via modulation of the brain's functional neurovascular unit. In chapter five, the authors propose a novel method for calculating (possibly multiple) univariate scores per individual to identify disease subtypes using multiple brain images (multi-modal brain images) obtained from multiple measurement or processing methods. Chapter six provides a detailed introduction of cognitive rehabilitation, presents the history and types of theories in this field, and then reviews studies that have recently used cognitive rehabilitation methods in different samples of patients and types of disorders and have reported the efficacy of these intervention methods. The causes, molecular mechanisms, and the diagnosis and treatment of prostate benign hyperplasia is examined in chapter seven. In chapter eight a model of a virus attacking a cell is proposed from the standpoint of sorption processes of cytoplasmic nucleotides, as a resource of both genomes. Using the method of gravitational non-invasive mass spectroscopy (GMS), the conformational state and the mechanism of action of domains in the myosin heads of the eye muscles of probants of different ages are studied in chapter nine.

Equine Neonatal Medicine A comprehensive guide to medical care for pregnant mares and neonatal foals Equine Neonatal Medicine offers an in-depth comprehensive reference for the clinical management of pregnant and periparturient mares and neonatal foals. Edited by leading experts in the field and written by experienced equine specialists, this textbook covers all aspects of providing veterinary care to mares and neonatal foals. Encompassing physiology, pathophysiology, theory, and practice, this textbook offers an authoritative, well-illustrated reference to equine perinatology. Topics covered include fetal monitoring, parturition, and peri-parturient disorders in the mare as well as diagnostic and therapeutic options for ill neonatal foals. The book: Covers aspects of veterinary care for the pregnant and peri-parturient mare and how to diagnose and treat the ill neonate Discusses fetal monitoring and parturition, and peri-parturient disorders in the mare Presents an exhaustive, detailed, and comprehensive reference for any veterinary practitioner involved with breeding management of horses and the care of neonatal foals Provides a clinical perspective, including both theory and practice Features more than 600 color images and diagrams to demonstrate the concepts discussed Equine Neonatal Medicine is an essential reference for any veterinary practitioner engaged with mares and foals, including specialists in equine medicine, equine and mixed animal practitioners, ambulatory practitioners, and veterinary students.

This book provides valuable information for investigators interested in the signaling and regulatory functions of adenosine and the adenine nucleotides. Topics covered in this comprehensive volume include the historical development of research on adenosine and adenosine triphosphate; various aspects of the formation, metabolism, release, transport, and receptors for endogenous adenosine and the adenosine triphosphate; functions of purines at the cellular level; the role of adenosine in the regulation of flow in different vascular beds; and angiogenesis. The book also addresses the purinergic regulation of the cardiac, renal, gastro-intestinal, and central nervous system, as well as potential therapeutic avenues for purine use. The book will be valuable to physiologists, pharmacologists, and other basic and clinical scientists interested in updating their knowledge of the expanding biological roles of these substances.

This is an open access book. ICEKIM is an annual conference that has been held four times. 2024 5th International Conference on Education, Knowledge and Information Management (ICEKIM 2024) will be held on April 19–21, 2024 in Chengdu, China. Information Technology, in the context of education, is revolutionizing the way we store, process, and communicate information, making it more accessible and meaningful. Advanced analytics, artificial intelligence, and cloud computing are some of the technological developments that have profoundly impacted the way educational institutions manage and use data, leading to more personalized and effective learning experiences. ICEKIM will focus on how information management promotes the effective utilization of knowledge and educational development, how to build effective information management assistance systems, and how to promote widespread adoption to meet the practical needs of society. ICEKIM 2024 is to bring together innovative academics and industrial experts in the field of Education, Knowledge and Information Management to a common forum. The primary goal of the conference is to promote research and developmental activities in Education, Knowledge and Information Management and another goal is to promote scientific information interchange between researchers, developers, engineers, students, and practitioners working all around the world.

Theranostics Nanomaterials in Drug Delivery presents the most recent advances in the development of theranostic nanomaterials for drug delivery. This book compiles reports and studies on the latest changes and improvements of theranostic nanocarriers such as nanoemulsions, liposomes, exosomes, polymeric micelles, PLGA nanoparticles, chitosan nanoparticles, dendrimer, quantum dots, silica nanoparticles, gold nanoparticles, silver nanoparticles, magnetic nanoparticles, and many more, all of which can help in the sensitive diagnosis, precise targeting, and efficient and controlled delivery of nanomaterials to control various diseases at different clinical stages. Theranostics nanomaterials in drug delivery will serve as a solid foundation and reference for pharmaceutical scientists, undergraduate and postgraduate students, researchers, and experts in the medical field involved in the development of advanced drug delivery systems. - Presents a compilation of thoroughly analyzed data and results regarding the usage of theranostics nanocarriers as a platform for diagnosis and treatment of various diseases - Gathers novel drug delivery applications of theranostics nanocarriers in biological milieu and discusses the principles behind the formation, characterization, applications, and future perspectives of theranostics for targeted therapy development - Discusses the most recent technologies in theranostics nanometrials to help readers define major gaps in knowledge that can lead new scientific breakthroughs and discoveries

This reference presents a detailed exploration of the synaptic tagging and capture model, which has been proposed to provide a conceptual basis for how short-term memories are transformed into long-term memories. The first edition of Synaptic Tagging and Capture served as a comprehensive introduction and overview of the field and covered the topics from molecular and cellular aspects to behavior. This second edition reflects the overwhelming amount of research on the topic in the past five years. Notably, it provides greater insight into the molecular and cellular mechanisms and behavioral aspects of tagging and capture, including reconsolidation, computational, and metaplastic models. Synaptic Tagging and Capture: From Synapses to Behavior, 2nd edition remains the definitive work in the field.

Dieser Band gibt einen Überblick über die jüngsten Entwicklungen und die Möglichkeiten des Einsatzes der Fließchemie im Bereich der heterozyklischen Synthese. Der heterozyklische Ring ist das wichtigste strukturelle Motiv in der überwiegenden Mehrheit der Naturstoffe und pharmazeutischen Verbindungen, da er abstimmbare Wechselwirkungen mit dem biologischen Ziel ermöglicht und zudem ein gewisses Maß an struktureller und metabolischer Stabilität verleiht. In jüngster Zeit hat die Fließchemie einen Paradigmenwechsel in der organischen Synthese eingeläutet, da sie mehrere einzigartige Vorteile gegenüber herkömmlichen Methoden bietet, wie z. B. eine drastische Beschleunigung träger Transformationen, höhere Ausbeuten, sauberere Reaktionen usw., und sie gewinnt allmählich große Aufmerksamkeit bei organischen Chemikern weltweit. Angesichts der Bedeutung von Heterozyklen in Naturstoffen, medizinischer Chemie und Arzneimitteln ist dieser Band gerechtfertigt und ergänzt den vorhergehenden Bandvon Topics in Organometallic Chemistry'Organometallic Flow Chemistry'.Dieser Band bietet einen vielseitigen Überblick über das Thema und erörtert nicht nur die jüngsten Fortschritte auf dem florierenden Gebiet der Fließchemie im Zusammenhang mit der heterocyclischen Chemie, sondern hilft den Forschern auch, die Chemie hinter diesen Reaktionen besser zu verstehen. Dies wiederum bietet eine Plattform für künftige Innovationen bei der Entwicklung neuartiger Umwandlungen unter kontinuierlichem Fluss. Daher wird dieser Band sowohl für Neulinge auf diesem Gebiet als auch für Experten in Wissenschaft und Industrie interessant sein.

This volume includes five chapters, each detailing recent advances in genetics research. Chapter one discusses how germline predisposition diseases are associated with a dramatically increased risk of developing myelodysplastic syndrome (MDS), acute myeloid leukemia (AML), and other malignancies. Chapter two explores how myeloid neoplasms originate from hematopoietic stem cells through the process known as clonal hematopoiesis. Chapter three summarizes current knowledge on the epigenetic changes induced by monoterpenes, providing an overview as well as recent findings regarding the topic of epigenetics. In chapter four, the authors investigate both the benefits and negative effects of genetic screening. Chapter five analyses the sequenced genomes of M. tuberculosis and the rearrangements of genes from the PE-PGRS family.

This non-fiction book provides information about the latest findings on research and therapy of nerve regeneration with catchy drawings and in understandable words. Why do nerves in the extremities regenerate, but the axons in the spinal cord do not? Can transplanted stem cells or biopolymers restore regeneration? Are bioprostheses able to functionally replace amputated arms or legs? Neuroscientist Lars Klimaschewski answers these questions and reports on exciting findings from anatomy, cell and molecular biology and neurotechnology. Find out, among other things, how a brain-computer interface processes signals from the brain in order to control the arm or leg muscles again via electrodes after a paraplegia.The translation was done with the help of artificial intelligence. A subsequent human revision was done primarily in terms of content.

Die Welt durchlebt eine beispiellose technologische Entwicklung, die alle Bereiche, besonders den Gesundheitssektor, beeinflusst. Die vierte industrielle Revolution bringt Neuerungen wie KI, das „Internet of Things“, Gentechnik, 3D-Druck und Robotik, die bereits Teil unseres Alltags geworden sind. Diese Technologien haben die Gesundheitsversorgung signifikant verändert, von elektronischen Patientenakten bis hin zur robotergestützten Chirurgie. Die Nephrologie, eine seit den 1960er Jahren bestehende Disziplin, hat durch Entdeckungen wie die Dialyse und die Nierentransplantation große Fortschritte gemacht. Heute beginnen moderne Technologien wie KI und 3D-Druck, die Nephrologie zu revolutionieren, mit dem Potenzial, die Behandlung von Nierenerkrankungen präziser und patientenorientierter zu gestalten. Das Buch beleuchtet die Anwendung dieser Technologien in der Nephrologie und deren Potenzial, die Versorgung zu verbessern. Es richtet sich an alle in der Nephrologen Tätigen, an Gesundheitsfachkräfte, an Forscher in verwandten Feldern und Medizinstudenten, und zeigt auf, wie diese Technologien die Behandlung von Nierenerkrankungen revolutionieren könnten.