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This encyclopedic reference takes into account the status of interventional neuroradiology in the treatment of acute ischemic stroke. It explains and discusses the various options to recanalize occluded extra-and intracranial vessels. The book provides an in-depth description of the different endovascular treatment strategies, including thrombectomy for large vessel inclusion, balloon angioplasty and intracranial atherosclerotic stenosis, and stenting of extra- and intracranial arterial dissections and their conservative treatment, and bypass surgery for subacute and chronic cerebral hypoperfusion. The book also offers tips and tricks for each procedure to enable readers to understand better the benefits and limitations of the endovascular management of ischemic stroke patients. Similarly, it explains the technical aspects of the procedures with their respective pros and cons. Written by respected experts in the field, the book will be a valuable resource for interventional neuroradiologists and neurologists, vascular and endovascular neurosurgeons, stroke neurologists, and other practitioners at all levels of experience.

To the non-neurologist, neurology can be one of the most intimidating fields of medicine, yet it includes many common problems faced in everyday primary care practice. Written specifically for the general clinician, Practical Approach to the Neurological Patient: A Clinician's Guide provides clear, up-to-date, and easy-to-understand guidance on commonly encountered issues, helping you take an informed approach to patients with neurological concerns. Dr. William J. Mullally and a team of expert contributing authors address headache, dizziness, stroke, pain, head trauma, and much more, making this volume an indispensable resource for primary care practitioners, internists, family practitioners, medical specialists, medical residents, nurse practitioners, physician associates, and students. - Offers concise, comprehensive content designed to help guide the primary care provider or non-neurologist on how to manage patients with common neurological conditions. - Covers timely topics such as women's neurology, neurogenetics, pain neurology, sleep disorders, dementia, and headache (including facial pain). - Includes Key Points in every chapter, MRI images that show brain lesions, figures and tables throughout, and clinical algorithms to support everyday decision making. - Features multidisciplinary input from physician authors who are contributors to the American Journal of Medicine, as well as a nurse practitioner and physician associates.

This extensively updated edition provides a comprehensive review of intensive care for neurologically injured patients from the emergency room and ICU through the operating room and post-surgical period in two comprehensive volumes. The Editors of this first volume present a comprehensive textbook that incorporates best practice/evidence-based medicine and performance improvement, while it champions the three characteristics needed in our neuro–ICUs: patient and family centered high-quality care, education, and discovery. This volume concentrates on neuroanatomy, diagnostic assessment and disease management, examining the neurological problems most frequently seen in intensive care, and describes the various types of neurosurgery and critical features of the management of patients. General issues are discussed across the textbook, such as cardiac care, fluids and electrolytes, nutrition, and monitoring as well as more specific conditions and complications including elevated intracranial pressure, seizures, and altered mental states. Listening to an injured brain is not easy. It takes knowledge, dedication, and understanding of the critically ill patient and their family. Textbook of Neurointensive Care Volume 1: Neuroanatomy, Diagnostic Assessment, Disease Management provides the reader with a detailed resource for studying this most complex area of medicine. It is thus essential reading for all trainees and professionals in critical care, neurosurgery, anesthesia and neurology.

This open access book offers an essential overview of brain, head and neck, and spine imaging. Over the last few years, there have been considerable advances in this area, driven by both clinical and technological developments. Written by leading international experts and teachers, the chapters are disease-oriented and cover all relevant imaging modalities, with a focus on magnetic resonance imaging and computed tomography.IDKD books are rewritten (not merely updated) every four years, which means they offer a comprehensive review of the state-of-the-art in imaging. The book is clearly structured and features learning objectives, abstracts, subheadings, tables and take-home points, supported by design elements to help readers navigate the text. It will particularly appeal to general radiologists, radiology residents, and interventional radiologists who want to update their diagnostic expertise, as well as clinicians from other specialties who are interested in imaging for their patient care.

Excerpt:'After a day of strenuous social activities, Lady Kesters was enjoying a well-earned rest, reposing at full length on a luxurious Chesterfield, with cushions of old brocade piled at her back and a new French novel in her hand. Nevertheless, her attention wandered from Anatole France; every few minutes she raised her head to listen intently, then, as a little silver clock chimed five thin strokes, she rose, went over to a window, and, with an impatient jerk, pulled aside the blind. She was looking down into Mount Street, W., and endeavouring to penetrate the gloom of a raw evening towards the end of March. It was evident that the lady was expecting some one, for there were two cups and saucers on a well-equipped tea-table, placed between the sofa and a cheerful log fire.'

This fourth edition offers a practical guide to endovascular treatment of cerebrovascular disease and provides a comprehensive reference for the related neurovascular anatomy and the various disorders that affect the vascular system. Chapters cover fundamental principles underlying cerebral and spinal angiography; interventional techniques, devices, and practice guidelines; and commonly encountered cerebrovascular disorders for which interventional and endovascular methods are appropriateBuilding on the previous edition, the text is presented similarly in style and scope to emphasize accessibility and ease of reading. All chapters are fully updated to include more recent data, and obsolete products and techniques are replaced with the most current technology. Some key updates include:A greater emphasis on the use of radial artery access for the discussed endovascular techniques.The associations of COVID-19 with ischemic stroke and the implicationsof providing care for cerebrovascular patients during a pandemic.An extensive update to the acute ischemic stroke chapter with new references and format to more closely follow the format of other chapters in that section.Expansion of the pediatric sections of disease chapters, including discussions of genetic associations with disease. This is an ideal guide for clinicians and trainees in neurology, neurosurgery and neuroradiology, as well as practicing clinicians in related fields caring for patients with cerebrovascular disease.

Comprehensive Precision Medicine holistically integrates essential and interconnecting disciplines that contribute to the make-up of Precision Medicine as we know it today. Encompassing almost 90 contributions from eminent scholars and professionals, the book's contents are organized across 3 volumes and 7 major subject areas, each representing a key pillar driving the evolution and progression of healthcare delivery. Precision medicine approaches will transform the training and practice of all aspects of professional healthcare delivery, including medicine, nursing, pharmacy, psychology, rehabilitation, and social work. This will be a fundamental reference resource for students, post-graduate trainees, researchers, scientists and clinicians interested in precision medicine. Additionally, this resource will be of interest to regulators, policy makers, and public health practitioners across the globe. - Provides comprehensive coverage and is basically a'one-stop'resource across all disciplines contributing to precision medicine - Authoritative guide edited by distinguished authorities who are shaping the advancement of precision medicine - Thematically organized, allowing for easy exploration across interconnecting disciplines - Digitally innovative resource with multimedia features that complement the text and provide additional learning and teaching resources

Section 9 provides diagnoses and manages uveitis, scleritis, and ocular inflammation. Additionally, a discussion on nonbacterial causes of infectious uveitis includes a subsection on SARS-CoV-2 and COVID-19, include scleritis, ocular involvement in HIV infection/AIDS, endophthalmitis, and masquerade syndromes.

This fully updated new edition is a comprehensive guide to interventional radiology (IR) for medical students, residents, early career attendings, nurse practitioners and physician assistants. The IR Playbook includes procedures, new and updated data, and new images, to stay on the cutting edge of IR. As a specialty, IR is constantly changing and evolving to apply newer technologies and techniques to a breadth of disease pathologies. This book addresses the growing need for a reference for trainees and early career professionals to gain a solid foundation. Let this book serve as your only resource from the first day you find out about IR to the day you take your certifying exam. One and done.The textbook is divided into two main sections, with many images and key point boxes throughout that offer high-yield pearls along with the specific How To's necessary for practice. The first section is designed to give readers an introduction to IR, including radiation safety, commonly used devices, patient care, and anatomy. The second portion is divided by procedure. These chapters cover pathophysiology, indications for treatment, as well as alternative treatments before delving into interventional therapy. This new edition has been fully updated throughout including several brand-new procedures and divided chapters to allow a more in depth look at several disease pathologies. IR Playbook gives medical students, residents, and trainees a full perspective of interventional radiology.

This second edition updates established evidence for contemporary management of ischemic stroke. Therapeutics for acute management, secondary prevention, recovery, rehabilitation, asymptomatic cerebral ischemia, special populations, and implementation of stroke systems of care are all discussed. Chapters are authored by leading academicians from around the world with real-world clinical practice experience, and comprise the scientific rationale and expert consensus recommendations, which underlie prevailing (and possibly future) therapeutic strategies for managing ischemic cerebrovascular disease. New chapter topics include neuroprotectants, treatment of the oldest old, brain-computer interfaces, disparities, and the global burden. The specialist or general practitioner will gain critical knowledge in stroke management, current clinical challenges and promising new therapies under investigation.

Cardiometabolic diseases are a group of metabolic dysfunctions mainly characterized by insulin resistance, impaired glucose tolerance, dyslipidemia, hypertension, and central adiposity that are major contributors to increased risk of acute vascular events such as myocardial infarction, heart failure and stroke. Cardiometabolic Diseases: Molecular Basis, Early Detection of Risks, and Management provides detailed information on all aspects of metabolic dysfunctions and associated risks for cardiometabolic diseases, including a thoughtful discussion of cellular and molecular mechanisms involved in the progression of metabolic risks, the approaches for the early detection and robust management of metabolic risks. Written by a team of expert contributors, this book is useful reading for researchers and clinicians interested on recent advances in etiology of cardiometabolic diseases, the latest noninvasive approaches for diagnosis, risk assessment tools, therapeutic strategies, and also aspects of prevention of cardiometabolic diseases. - Covers all aspects of cardiometabolic diseases, from cellular and molecular mechanisms involved in the development of metabolic risks to clinical practice - Provides established guidelines that facilitate effective management of the independent risk factors that promote vascular diseases - Discusses the use of diagnostic tools to empower patients to self-monitor the progress or regress of modifiable risks

Strokes are divided into two groups: ischemic strokes (85%) and hemorrhagic strokes (15%). Brain tissue is very sensitive to ischemia. When the blood flow is interrupted in the vessels feeding the brain, permanent damage occurs within minutes in the areas fed by that vessel. Especially in large vessel occlusions, an irreversible area called ischemic nucleus occurs in areas where the minute blood flow falls below the critical level. There are different blood flow belts that increase from the regions surrounding the ischemic nucleus towards the periphery and are fed by collateral vascular systems. Infarcts have not yet occurred in these areas under ischemic stress. This region is called the penumbra. This area can be saved by opening the vessel in suitable patients presented in the acute period. This is valid for vascular occlusion, but not for brain hemorrhages. Rarely, if an aneurysm is detected in subarachnoid hemorrhages, angiographic intervention may be required to prevent re-bleeding. Early and appropriate treatment of a stroke, which is important in terms of mortality and morbidity, is of vital importance. In our book, the identification and prevention of risk factors, as well as stroke treatment, will be covered. In this context, our book is intended to be a resource for medical doctors and students.

Narratives of Qualitative Research uses a novel form of writing about how to do qualitative research called a praxis narrative. Each narrative is told from the author's perspective in carrying out one of his past research studies in the social sciences.Told chronologically and in a first-person voice, the narratives position the reader alongside the narrator so as to vicariously experience how research happens in its situated particulars. Rather than a set of idealizations and universalized pronouncements, the author reveals what really goes on when one is in the thick of complex and challenging research studies, the points of trouble along with the successes. This will be relevant to researchers who have already undertaken one or more empirical research studies (though not necessarily using qualitative approaches) and now find themselves facing something new: a new analytic method, a new theoretical lens, a new form of data collection, a new domain of research questions, a new rhetorical approach. This requires letting go of the secure handholds of prescribed methods and responding to the contingencies that arise in the midst of the research. The reader is invited to follow along as the author makes visible his praxis of qualitative research.Unlike more conventional texts, in this unique alternative, the reader can follow the author's journey through his research studies as a way to reorient their conception of qualitative research and their own praxis of it. This is fascinating reading for qualitative researchers and students taking qualitative research courses, across the social sciences, education, and behavioural sciences.

This book serves as a clinical guide for the growing number of Advanced Practice Clinicians (APC) who care for stroke patients. It covers the entire spectrum of stroke care: acute, inpatient, and outpatient, as well as fundamental topics like neuroanatomy and radiology. Each chapter succinctly reviews crucial topics designed to guide APCs of any experience level with clinical decision-making. To further enrich the text, we incorporated guidelines, relevant trial data written in plain language, decision-making algorithms, clinical pearls, and case vignettes. Since this is a book for APCs, each chapter is written in a clear, clinically focused manner by an experienced APC with a collaborating physician. We hope this is a helpful resource not only for APCs in neurology but also for those practicing in other specialties, primary care, and students learning about stroke care.

The Brain of the Critically Ill Pregnant Woman is a volume in the Critical Care in Obstetrics series. This novel reference educates physicians, nurses, and all allied healthcare personnel on updates for caring for pregnant women with neurological compromise. The book's authors have gathered the best evidence-based material that is explicitly focused on severe neurological complications in pregnant patients and postpartum. Among the chapters, the book covers medical-surgical complications that any patient can present, such as head trauma and complications specific to pregnancy. - Includes obstetric concepts with updated knowledge of pathophysiology - Offers best practice approaches and interventions regarding the fetus - Explores the use and effects of drugs in the pregnant patient and during nursing - Written by authors with extensive clinical experience in neurocritical care and critical obstetric care

A transdisciplinary approach to the medical, radiologic, interventional, and surgical treatment of strokeIn the last decade, advances in interventional, microsurgcial, radiosurgical techniques, medical approaches and imaging technology have dramatically changed the management of ischemic stroke. Perhaps the most important advance has been the increasing collaboration between multispecialty clinicians to deliver team-based stroke care. Hemorrhagic and Ischemic Stroke: Medical, Imaging, Surgical, and Interventional Approaches, Second Edition by renowned neurosurgeons Bernard R. Bendok and H. Hunt Batjer and acclaimed contributors provides a user-friendly, single resource for managing ischemic and hemorrhagic stroke. The second edition has been updated to reflect progress, most notably acute evaluation and triage, advanced imaging, critical care and medical support, and endovascular and surgical interventions. In addition to scientifically supported content, readers will benefit from pragmatic, real-world applications and concise, practical reviews.Organized into four sections and 41 chapters, the text starts with the section Acute Triage, which includes early diagnosis and medical decision-making, advances in medical imaging, innovations in prehospital management of stroke, and the promise of telestroke networks. The second section, Critical Care, covers the importance of astute clinical examination, stabilization, and advanced neuromonitoring techniques. The third section, Open Surgical, Minimally Invasive, and Microsurgical Approaches, reviews recent surgical innovations that have the potential to be lifesaving and enhance quality of life in select patients. The fourth and final section, Neurointerventional Approaches, explores recent innovations in image-guided catheter techniques to deliver new therapies for stroke treatment and prevention.Key HighlightsThe often difficult yet important adjudication of antithrombotic medication useInsightful discussion of the importance of prehospital systems of care and stroke center certificationInsightful discussions of interventional and microsurgical approaches for hemorrhagic and ischemic stroke managementMedical illustrations and author-narrated videos provide a visual learning experienceClinical pearls and case presentations enhance learning and retention of knowledgeThe goal of this book is to increase collaborative stroke management among neuroradiologists, neurologists, neurosurgeons, neuroanesthesiolgists, neurologic critical care physicians, and allied health care professionals to achieve better patient outcomes.

It is the first publication of its kind in the form of a textbook of cardiology from India to the world. Over 300 contributors from India and abroad have contributed their prestigious chapters in this book, focuses on every aspect of clot management with enormous information about advances in clinical approach, imaging including echocardiography, multimodality imaging, drug, mechanical and surgical interventions for better patient care with clot inflicted morbidity and mortality reduction in various clinical situations and has tremendous innovative and research potential of understanding advances and innovations in clot care for the undergraduates, postgraduates, practicing cardiologists, endocrinologists, nephrologists, neurologists, critical care, pulmonologists, pediatricians, pediatric surgeons, physicians, cardiovascular surgeons, imaging experts and nutritionists, etc. The book including 36 sections and 158 chapters.

Written by neurosurgery residents for neurosurgery residents, The Neurosurgical Consult Book focuses on the initial care and treatment of the neurosurgical consult patient, providing the key guidance you need when quick clinical management decisions are critical. You'll learn to recognize the acuity of patient presentation and determine how to immediately triage the needs of the patient at an appropriate level of care. This portable, practical guide helps you quickly steer neurosurgical patients to medical stability and safety until a definitive clinical management plan is determined. - Features a real-life approach with chapters titled by the symptoms and clinical presentation of the patient, not by neurosurgical diagnosis. - Begins each chapter with the actual consult notification from the consulting team, mimicking how the neurosurgery provider is notified about a new patient in practice. - Presents initial imaging as it occurs in real life—whether imaging has already been done or whether the consulting physician needs guidance on what imaging is needed. - Includes Walking Thoughts, guidance on how to tailor your thoughts toward the most important and pressing issues facing the patient before even meeting them, so that upon seeing the patient, the most important questions are asked first. - Covers the Glasgow Coma Scale, the systematic thought process behind triage management, and learning points to remember when seeing a particular type of neurosurgical patient. - Summarizes evidence-based standards of care and key literature. - An excellent learning tool for neurosurgery and neurology residents as well as neurosurgery fellows, registered nurses, neurocritical care health care providers, clinical fellows, physician assistants, clinical nurse specialists, nurse practitioners, travel nurses, advance practice practitioners, emergency room providers, and medical students rotating in neurology, neurosurgery, and neurosciences.

EVIDENCE-BASED EMERGENCY CARE DIAGNOSTIC TESTING AND CLINICAL DECISION RULES THIRD EDITION Improve and streamline the diagnostic decision-making process in emergency care The newly revised third edition of Evidence-Based Emergency Care: Diagnostic Testing and Clinical Decision Rules offers an updated review of the evidence and expert discussion of relevant issues in diagnostic testing in the everyday practice of emergency medicine. This book also provides a detailed overview of the science of diagnostic testing and reviews the process behind the development of clinical decision rules. The focus is asking and answering practical questions using original research studies, while commenting on the best available evidence for relevant clinical topics. Readers will also find: Comprehensive explorations of COVID-19, telemedicine, trauma, cardiology, infectious disease, and surgical and abdominal complaints Practical discussions of urology, neurology, hematology, ophthalmology, pulmonology, rheumatology, and geriatric medicine Exploration of practice and policy considerations of testing in an era of limited resources The book is perfect for emergency medicine physicians, nurses, and other allied health professionals. Readers of Evidence-Based Emergency Care: Diagnostic Testing and Clinical Decision Rules, Third Edition will also earn a place in the libraries of administrators and managers in healthcare settings seeking to optimize the use of scarce resources while maintaining the highest standards of care.

Reviews immune-mediated eye disease, summarizing basic immunologic concepts, ocular immune responses and special topics in ocular immunology. Includes an interactive uveitis diagnostic algorithm and a chapter covering scleritis. Discusses the clinical approach to uveitis and reviews noninfectious (autoimmune) and infectious forms of uveitis, with an expanded section on viral uveitis and material on infectious and noninfectious scleritis. Enhanced detection of infectious agents by immunologic and genetic methods and biologic therapeutics are detailed. Also covers endophthalmitis, masquerade syndromes, complications of uveitis and ocular aspects of AIDS.

This practical guide for trainees and advanced practice providers covers the essential management of hospitalized patients with acute neurologic conditions. Divided into five sections, this text serves as an incredibly easy-to-use, visually accessible, how-to manual that covers exactly what every responding clinician needs to know to care for the patient in front of them.The first section provides tangible guidance about how to pre-round, structure a presentation, examine neurologically ill patients, and interpret the core diagnostics obtained in many neurology patients: CT, MRI and EEG. The next three sections cover common complaints encountered in the hospital: spanning from non-vascular admissions, vascular & stroke neurology topics, and core neurocritical care principals and chief complaints. Throughout are checklists, scoring systems, pro-tips, images, helpful reminders, as well as concise summary of the pertinent literature. This is an ideal guide for medicalstudents, neurology & neurosurgery trainees and advanced practice providers, as well as experienced professionals who want to brush up on the latest updates.

Reviews immune-mediated eye disease, summarizing basic immunologic concepts, ocular immune responses and special topics in ocular immunology. Includes an interactive uveitis diagnostic algorithm and a chapter covering scleritis. Discusses the clinical approach to uveitis and reviews noninfectious (autoimmune) and infectious forms of uveitis, with an expanded section on viral uveitis and material on infectious and noninfectious scleritis. Enhanced detection of infectious agents by immunologic and genetic methods and biologic therapeutics are detailed. Also covers endophthalmitis, masquerade syndromes, complications of uveitis and ocular aspects of AIDS.

Infective Endocarditis: A Multidisciplinary Approach provides a comprehensive review of infective endocarditis and covers the entire spectrum of medical care for these challenging patients. It covers the ever-increasing scope of the problem, including epidemiology, as well as diagnostic work-up, microbiology, medical therapy, and surgical therapy for this disease. The book also addresses the opioid epidemic and rising infective endocarditis incidence in this population. Each type of practitioner can use this book as a definitive resource in reviewing aspects of care related to the endocarditis patient. This book will also serve as an updated resource to provide recent evidence regarding the management of these patients, as well as author perspectives and approaches to tackling the often complex and challenging issues revolving around care of the endocarditis patient. This is an essential reference and an authoritative source for infective endocarditis and provide physicians, nurses, social workers, and everyone who is routinely involved in the care of these patients. - Provides a thorough, yet concise review from a multidisciplinary perspective on the work-up and management of infective endocarditis - Presents updated reviews on evidence and current guidelines for treating patients with infective endocarditis - Provides discussion on controversial aspects of management, both medical and ethical

This book summarizes more than four decades of research on imitation in infancy and its relation to early learning and sociocognitive development in typically and atypically developing children. The studies were carried out in a Scandinavian context and thus provide important cultural validation of the central developmental processes. The book is divided into three parts: Part one focuses on the social and cognitive aspects of imitation, discussing links to early parent-infant interaction, and developmental meaning. It addresses evidence for an imitative capacity at birth for typical and atypical infants. Also covered are early individual differences in imitation, the role of imitation as a social and cognitive learning mechanism in early development, and possible links between imitation and temperament. Part two presents unique longitudinal studies on early memory development using deferred imitation as the key method. It discusses the biological basis of memory and explores the idea that deferred imitation is an indicator of an infant's ability to understand intentions. Part three focuses on imitation in young children with autism and with Down syndrome. It examines the role of imitation as a “deficit” as well as a vehicle for change when used interactively in early interventions for children with autism. Imitation from Infancy Through Early Childhood is an essential resource for researchers, professors, and graduate students as well as clinicians and other professionals in developmental psychology, cognitive development, psycholinguistics, child psychiatry, and developmental neuroscience.

This book aims to cover the majority of neurovascular diseases and management. The first section reviews neurovascular anatomy, the basics of angiography, and the basics of craniotomies for neurovascular diseases. Next, an entire section is devoted to intracranial aneurysms, covering the natural history, subarachnoid hemorrhage, endovascular management, microsurgical management, and vasospasm. Following this, a number of chapters are devoted to stroke including natural history, mechanical thrombectomy, intracranial stenosis, Moyamoya disease, bypass surgery, vertebrobasilar insufficiency, intracerebral hemorrhage, sinus thrombosis, and the surgical and endovascular management of extracranial carotid disease. Next, the text covers vascular malformations including arteriovenous malformation, arteriovenous fistulas, carotid cavernous fistulas, vein of Galen malformations, spinal malformations, and cavernous malformations. Finally, the book discusses a few miscellaneous topics including more recent advances in neurovascular care such as venous sinus stenting for idiopathic intracranial hypertension and middle meningeal artery embolization for subdural hematoma. Written by experts in the field, Introduction to Vascular Neurosurgery provides a comprehensive summary of neurovascular disease and management. The book can be used as a daily reference and serves as a trusted resource for medical students, residents, fellows, and young attendings.

Comprehensive Pharmacology, Seven Volume Set is organized into twelve sections that explore therapeutic areas, with a total of 320 comprehensive articles and 6,800 pages of important findings. Sections contain highly detailed coverage of information that has been overseen by an editorial board made up of well-respected, field leading experts. The content in this book offers readers an in-depth and easily accessible reference work on every aspect of pharmacological research surrounding the pharmacology of all therapeutic applications of drugs, their mechanism of action and their therapeutic values. These elements are essential as drugs are almost never tested and developed in the actual therapeutic system, but rather in test systems from which parameters must be determined to predict activity in systems of varying ambient physiology. As different technologies rapidly evolve, there is an ever-increasing level of knowledge about the pharmacology of known drugs, along with increasing capability to utilize pharmacological systems to predict new drug activity, all of which must be communicated to professionals in varying fields. - Contains chapters that follow a consistent and templated approach, resulting in well-structured content that enhances user experience and appeal - Offers a comprehensive review on a wealth of information on pharmacology and how it utilizes concepts and techniques from a broad array of sciences, ranging from chemistry to physiology to medicine - Includes a wider use of color and multimedia content, with interactive features, links, computational modeling and animations to illustrate the effects of toxic substances in various contexts

NEW YORK TIMES BESTSELLER • He's American royalty. She comes from a troubled past. Is their love story meant to be? This “lively page-turner” (The New York Times) offers a nostalgic, hopelessly romantic escape—from the author of Something Borrowed and The Lies That Bind.“I'm a sucker for an iconic, against-all-odds love story, and Meant to Be truly delivers.”—Tia Williams, author of Seven Days in June “A chic, history-inspired summer read [that] strikes a careful balance between simply retelling the true story of JFK Jr. and his wife, Carolyn Bessette, and crafting an entirely new one.”—BookreporterThe Kingsley family is American royalty, beloved for their military heroics, political service, and unmatched elegance. In 1967, after Joseph S. Kingsley, Jr. is killed in a tragic accident, his charismatic son inherits the weight of that legacy. But Joe III is a free spirit—and a little bit reckless. Despite his best intentions, he has trouble meeting the expectations of a nation, as well as those of his exacting mother, Dottie.Meanwhile, no one ever expected anything of Cate Cooper. She, too, grew up fatherless—and after her mother marries an abusive man, she is forced to fend for herself. After being discovered by a model scout at age sixteen, Cate decides that her looks may be her only ticket out of the cycle of disappointment that her mother has always inhabited. Before too long, Cate's face is in magazines and on billboards. Yet she feels like a fraud, faking it in a world to which she's never truly belonged.When Joe and Cate unexpectedly cross paths one afternoon, their connection is instant and intense. But can their relationship survive the glare of the spotlight and the so-called Kingsley curse? In a beautifully written novel that captures a gilded moment in American history, Emily Giffin tells the story of two people searching for belonging and identity, as well as the answer to the question: Are certain love stories meant to be?

This book offers a comprehensive review of smart technologies and perspectives on their application in urban engineering. It covers a wide range of applications, from transport and energy management to digital manufacturing, smart city, environment, and sustainable development, providing readers with new ideas for future research and collaborations. This book presents select papers from the International Conference on Smart Technologies in Urban Engineering (STUE-2022), held to commemorate the 100th anniversary of the O.M. Beketov National University of Urban Economy in Kharkiv, Ukraine, on June 9–11, 2022. All the contributions offer plenty of valuable information and would be of great benefit to the experience exchange among scientists in urban engineering.

This comprehensive, case-based resource provides the state-of-the-art knowledge that can help readers improve access and optimize delivery of stroke thrombectomy. Improving access to stroke is of particular importance because patients often misinterpret their symptoms or cannot speak for themselves if they have aphasia. More importantly, access needs to be organized because stroke therapies are all extremely time-sensitive. Scalable, choreographed protocols are necessary for emergency medical systems to ‘capture'stroke patients and automatically transport and triage to time-sensitive treatments. Many of the chapters in the first section on Fundamentals and Systems provide valuable insight in improving access to stroke care. Replete with illustrative case studies and emphasizing that treatment approaches to stroke should not be comprised of a one-size-fits-all approach, this illuminating title provides the complete thought, detail, insight and organization that will help readers meet the needs of stroke patients with large vessel occlusions. 12 Strokes: A Case-based Guide to Acute Ischemic Stroke Management examines the primary technical principles that underlie the current thrombectomy approaches. Instead of continuing the conceptual dichotomy of stent vs. aspiration, many of the chapters look at underlying principles and then discuss ways in which the currently available devices and approaches can best exploit them. The variety, creativity and detail in many of these chapters will help the reader develop a deeper understanding that might assist their ability to successfully take care of their next patient that ‘doesn't follow the textbook.'In addition, the anatomic and pathophysiologic classification of the core Twelve Chapters will help readers organize their thinking and approach. This knowledge, particularly because it is organized based on common, challenging syndromes, will arm the reader to quickly recognize patterns and deftly adapt their management approaches to the needs of the patient. An invaluable contribution to the clinical literature, 12 Strokes: A Case-based Guide to Acute Ischemic Stroke Management will be of great interest to not only neurosurgeons and neurologists but other specialists, primary care providers, and trainees as well.

Interventional Neuroradiology, Volume 179, provides a basic outline of the field of interventional neuroradiology that is accessible to fellows, residents, clinicians and researchers in various disciplines, from diagnostic and interventional radiology to vascular neurology, general and vascular neurosurgery, and vascular biology. This volume offers a timely update to experienced clinical practitioners in a logical, easy-to-follow format. Content includes neurovascular anatomy, vascular biology, neurovascular physiology, vascular imaging, as well as sections on the diagnosis and therapeutic treatment of neurovascular disease. - Explores the general scope of current clinical interventional neuroradiology, both for endovascular and percutaneous image-guided diagnosis and interventions in a variety of pathologies - Defines basic physiological principles (e.g., cerebral perfusion pressure, intracranial pressure, vasospasm, tissue osmolality) with reference to those most essential to the management of neurovascular diseases - Discusses pathophysiology and the unique challenges of pediatric cerebrovascular diseases, as well as endovascular and surgical therapies

A practical guide for radiologists on providing high yield disease-specific reportsMultiple studies show that referring physicians have a clear preference for structured radiology reports due to clarity and ease of interpretation, yet a one-size-fits all approach does not address disease complexities. Concurrently, the use of structured radiology templates has increased, driven in part by the need to comply with big data and artificial intelligence as well as reimbursement. Standardization of reporting is one of the first essential steps in the transformation of radiology from'the art of imaging'to a robust data science.Radiology Structured Reporting Handbook: Disease-Specific Templates and Interpretation Pearls by Professors Olga R. Brook, Wieland H. Sommer, and esteemed colleagues is a highly practical guide on structured reporting for every major area of radiology. Featuring disease-specific templates, the book is organized in six sections and 53 chapters. Section one covers core foundation topics, from different definitions of structured reporting and pros and cons to change management and how to build templates. Five disease-specific sections encompass specific cancers and a variety of abdominal, thoracic, neurological, and cardiovascular diseases and conditions.Key HighlightsDownloadable disease-specific templates for a variety of clinical entities including cardiovascular, thoracic, abdominal, oncological, and neuroradiologyEssential interpretation pearls for specific diseases from top experts in a bullet format, accompanied by relevant figures and tablesTogether, the templates and pearls provide an essential and unique practice resource for optimal and clinically relevant reporting. The book also serves as a succinct educational tool for radiology trainees and practicing radiologists who may not interpret specific highly specialized types of studies on a daily basis.

Reviews immune-mediated eye disease, summarizing basic immunologic concepts, ocular immune responses and special topics in ocular immunology. Includes an interactive uveitis diagnostic algorithm and a chapter covering scleritis. Discusses the clinical approach to uveitis and reviews noninfectious (autoimmune) and infectious forms of uveitis, with an expanded section on viral uveitis and material on infectious and noninfectious scleritis. Enhanced detection of infectious agents by immunologic and genetic methods and biologic therapeutics are detailed. Also covers endophthalmitis, masquerade syndromes, complications of uveitis and ocular aspects of AIDS.

The Clinical Cardiac Electrophysiology Handbook, Second Edition, is a concise presentation in outline format of the practical information needed to understand the subtleties of cardiac electrophysiology. The Handbook focuses on the “how-to” management of arrhythmias, along with an understanding of the “why.” “... a quick source for information in the EP lab or on the wards offering the ability to quickly review the essential components before a case or to reinforce new notions and practices encountered during a case.” — From the Preface Fully illustrated with more than 250 figures and tables. Equally valuable to the cardiology fellow on their electrophysiology rotation, or an EP fellow or technologist working in the EP lab. New and updated sections in the Second Edition: Ablation energy and biophysics, including pulsed field ablation AF ablation techniques adjunctive to pulmonary vein isolation Alternatives to cardiac resynchronization therapy His bundle pacing Intracardiac echocardiography Left atrial appendage occlusion

This book provides a concise review for practitioners in preparation for the Vascular Neurology Boards including the Maintenance of Certification exam. This valuable second edition is expertly written and supplemented with new treatment paradigms as well as new and updated trial results.. Beginning with a general overview on how to prepare for the exam, this practical guide emphasizes clinically relevant scientific principles that must be mastered by the stroke clinician. Subsequent chapters review acute management of ischemic and hemorrhagic stroke, specific epidemiological risk factors, stroke pathophysiology, stroke classification, and vascular neuroanatomy. This edition also reviews cardiac and hematological considerations in stroke patients, genetic stroke syndromes, vascular malformations, cognitive disorders, stroke rehabilitation, and peri-operative stroke management. Vascular Neurology Board Review, Second Edition, is not only written to act as a guide for the neurology resident and fellow, but also as a useful framework for non-neurologists.

This book constitutes the proceedings of the 11th International Conference on Computational Logistics, ICCL 2020, held in Enschede, The Netherlands, in September 2020.The 49 papers included in this book were carefully reviewed and selected from 73 submissions. They were organized in topical sections named: maritime and port logistics; vehicle routing and scheduling; freight distribution and city logistics; network design and scheduling; and selected topics in logistics.Due to the Corona pandemic ICCL 2020 was held as a virtual event.

The Microsoft Azure cloud is an ideal platform for data-intensive applications. Designed for productivity, Azure provides pre-built services that make collection, storage, and analysis much easier to implement and manage. Azure Storage, Streaming, and Batch Analytics teaches you how to design a reliable, performant, and cost-effective data infrastructure in Azure by progressively building a complete working analytics system.Summary The Microsoft Azure cloud is an ideal platform for data-intensive applications. Designed for productivity, Azure provides pre-built services that make collection, storage, and analysis much easier to implement and manage. Azure Storage, Streaming, and Batch Analytics teaches you how to design a reliable, performant, and cost-effective data infrastructure in Azure by progressively building a complete working analytics system. Purchase of the print book includes a free eBook in PDF, Kindle, and ePub formats from Manning Publications. About the technology Microsoft Azure provides dozens of services that simplify storing and processing data. These services are secure, reliable, scalable, and cost efficient. About the book Azure Storage, Streaming, and Batch Analytics shows you how to build state-of-the-art data solutions with tools from the Microsoft Azure platform. Read along to construct a cloud-native data warehouse, adding features like real-time data processing. Based on the Lambda architecture for big data, the design uses scalable services such as Event Hubs, Stream Analytics, and SQL databases. Along the way, you'll cover most of the topics needed to earn an Azure data engineering certification. What's inside Configuring Azure services for speed and cost Constructing data pipelines with Data Factory Choosing the right data storage methods About the reader For readers familiar with database management. Examples in C# and PowerShell. About the author Richard Nuckolls is a senior developer building big data analytics and reporting systems in Azure. Table of Contents 1 What is data engineering? 2 Building an analytics system in Azure 3 General storage with Azure Storage accounts 4 Azure Data Lake Storage 5 Message handling with Event Hubs 6 Real-time queries with Azure Stream Analytics 7 Batch queries with Azure Data Lake Analytics 8 U-SQL for complex analytics 9 Integrating with Azure Data Lake Analytics 10 Service integration with Azure Data Factory 11 Managed SQL with Azure SQL Database 12 Integrating Data Factory with SQL Database 13 Where to go next

William Morris (1834–96) was an English poet, decorative artist, translator, romance writer, book designer, preservationist, socialist theorist, and political activist, whose admirers have been drawn to the sheer intensity of his artistic endeavors and efforts to live up to radical ideals of social justice. This Companion draws together historical and critical responses to the impressive range of Morris's multi-faceted life and activities: his homes, travels, family, business practices, decorative artwork, poetry, fantasy romances, translations, political activism, eco-socialism, and book collecting and design. Each chapter provides valuable historical and literary background information, reviews relevant opinions on its subject from the late-nineteenth century to the present, and offers new approaches to important aspects of its topic. Morris's eclectic methodology and the perennial relevance of his insights and practice make this an essential handbook for those interested in art history, poetry, translation, literature, book design, environmentalism, political activism, and Victorian and utopian studies.

Reviews immune-mediated eye disease, summarizing basic immunologic concepts, ocular immune responses and special topics in ocular immunology. Includes an interactive uveitis diagnostic algorithm and a chapter covering scleritis. Discusses the clinical approach to uveitis and reviews noninfectious (autoimmune) and infectious forms of uveitis, with an expanded section on viral uveitis and material on infectious and noninfectious scleritis. Enhanced detection of infectious agents by immunologic and genetic methods and biologic therapeutics are detailed. Also covers endophthalmitis, masquerade syndromes, complications of uveitis and ocular aspects of AIDS.

Cognitive Development and Cognitive Neuroscience: The Learning Brain is a thoroughly revised edition of the bestselling Cognitive Development. The new edition of this full-colour textbook has been updated with the latest research in cognitive neuroscience, going beyond Piaget and traditional theories to demonstrate how emerging data from the brain sciences require a new theoretical framework for teaching cognitive development, based on learning. Building on the framework for teaching cognitive development presented in the first edition, Goswami shows how different cognitive domains such as language, causal reasoning and theory of mind may emerge from automatic neural perceptual processes. Cognitive Neuroscience and Cognitive Development integrates principles and data from cognitive science, neuroscience, computer modelling and studies of non-human animals into a model that transforms the study of cognitive development to produce both a key introductory text and a book which encourages the reader to move beyond the superficial and gain a deeper understanding of the subject matter. Cognitive Development and Cognitive Neuroscience is essential for students of developmental and cognitive psychology, education, language and the learning sciences. It will also be of interest to anyone training to work with children.

A deaf woman must stop a serial killer obsessed with targeting everyone she loves in this intense psychological thriller. Annie Black, who is profoundly deaf, has always looked out for her friend's deaf son Toby. Now she's looking for him as part of a search party. And when the fifteen-year-old turns up murdered, it's only the beginning of Annie's nightmare. Someone is targeting people close to her—someone merciless and very smart. Teaming up with the lead Detective, Annie attempts to understand the killer's mind. With everyone she cares about in mortal danger, her work puts the entire deaf community at risk. And as the murders escalate, the killer's obsession grows. Will the police untangle the killer's motivation before it's too late?

The content of this book is organized into 25 chapters, beginning with basic immunology related to blood group serology and interactions between antigens and antibodies. The successive chapters cover the most common blood groups, pretransfusion testing protocols, transfusion reactions, blood components, apheresis (one of the fastest growing and most promising methods of blood collection and component harvesting), hemolytic disease of the newborn, hemovigilance, quality assurance and regulatory issues. The book is written at a level adaptable for multiple categories of students.

The rapid expansion of clinical knowledge in the field of neurology warrants a new edition of this highly regarded textbook of neurology. In addition to the anchor chapters on major areas such as headache, stroke, developmental disorders, dementia, epilepsy, acquired metabolic disorders, and others, several new chapters have been added to meet the clinical demand for those in practice. This edition features new chapters on neurotoxicology, neuroimaging, and neurogenetics including basic and more advanced concepts for the practitioner. Finally, as the health care system continues to evolve, a new chapter on population health and systems of care reflects current practice in team care, patient-centric approaches, and value-based care.•Pithy bullet points and standard prose allow the reader to assimilate concepts and key messages with ease•Summary tables, neuroimages, photomicrographs, neuroanatomic drawings, gross and microscopic neuropathologic specimen photos, graphics, and summary boxes further enhance the text•Chapters are crafted in a way to appeal to both the visuospatial and analytic functional centers of the brain, as we stimulate the senses and learn Hankey's Clinical Neurology, Third Edition, will be of value to medical students, physicians in training, neurology fellows, neurologist and neurosurgeon practitioners, and advanced practice professionals (e.g., nurse practitioners and physician assistants) who are faced with neurologic practice challenges.

Perfect for residents, medical students, generalists, nurses, and other healthcare professionals who need a practical, working knowledge of neurology, Netter's Neurology, 3rd Edition, provides a concise overview highlighted by unique, memorable Netter illustrations. This award-winning visual resource showcases the well-known work of Frank H. Netter, MD, and his successor, Carlos Machado, MD, a physician who has created clear, full-color illustrations in the Netter tradition. Offers a quick and memorable summary of general neurology and its intersection with internal medicine, neurosurgery, ophthalmology, psychiatry, and orthopaedics. Concise text is presented in a templated format for fast, easy access to information. Features more than 450 Netter and Netter-style images that highlight anatomy, pathophysiology, and clinical presentation related to neuroanatomical and neurologic concepts. Helps you make correlations between anatomy, pathology, physiology, and pharmacology in a clinical setting. Clinical vignettes throughout provide real-world applications to each topic. Includes access to 25 printable patient education brochures in the enhanced eBook version. Features new chapters on Laboratory Evaluation in Neurology; Neuroimaging in Neurologic Disorders; and Neurologic Emergencies and Critical Care. Presents the underlying anatomy in living patients through neuroimaging coverage, including MR, CT, and PET.

Quantitative Magnetic Resonance Imaging is a'go-to'reference for methods and applications of quantitative magnetic resonance imaging, with specific sections on Relaxometry, Perfusion, and Diffusion. Each section will start with an explanation of the basic techniques for mapping the tissue property in question, including a description of the challenges that arise when using these basic approaches. For properties which can be measured in multiple ways, each of these basic methods will be described in separate chapters. Following the basics, a chapter in each section presents more advanced and recently proposed techniques for quantitative tissue property mapping, with a concluding chapter on clinical applications. The reader will learn: - The basic physics behind tissue property mapping - How to implement basic pulse sequences for the quantitative measurement of tissue properties - The strengths and limitations to the basic and more rapid methods for mapping the magnetic relaxation properties T1, T2, and T2• - The pros and cons for different approaches to mapping perfusion - The methods of Diffusion-weighted imaging and how this approach can be used to generate diffusion tensor - maps and more complex representations of diffusion - How flow, magneto-electric tissue property, fat fraction, exchange, elastography, and temperature mapping are performed - How fast imaging approaches including parallel imaging, compressed sensing, and Magnetic Resonance - Fingerprinting can be used to accelerate or improve tissue property mapping schemes - How tissue property mapping is used clinically in different organs - Structured to cater for MRI researchers and graduate students with a wide variety of backgrounds - Explains basic methods for quantitatively measuring tissue properties with MRI - including T1, T2, perfusion, diffusion, fat and iron fraction, elastography, flow, susceptibility - enabling the implementation of pulse sequences to perform measurements - Shows the limitations of the techniques and explains the challenges to the clinical adoption of these traditional methods, presenting the latest research in rapid quantitative imaging which has the possibility to tackle these challenges - Each section contains a chapter explaining the basics of novel ideas for quantitative mapping, such as compressed sensing and Magnetic Resonance Fingerprinting-based approaches

The book provides detailed information on all major neuroemergencies, and includes a detailed checklist for practical care during the first hour of an emergency. Reinforcing the concept of quality care for better outcomes in patients with neurological diseases, the book discusses approaches to comatose patients, neurological evaluation, neuropharmacology, neuroradiology, traumatic brain and spine injury, and various other neurological disorders. The field of neuroanesthesiology and neurocritical care has expanded with the advent of newer, complex surgeries, and neurocritical care is becoming an established subspecialty of neuroscience. Neurological emergencies require special care since prevention of secondary damage to the brain is of paramount importance. A valuable resource for intensivists, neurointensivists, emergency medicine physicians, neurology and neurosurgeons and nursing professionals involved in neurocare, this book also serves as study material forparticipants of the two-day course on “Acute Neuro Care” designed by the Indian Society of Neuroanesthesiology and Critical Care (ISNACC).

Ischemic and hemorrhagic strokes are common neurological emergencies. In recent years, endovascular intervention has become a standard of care in treating acute ischemic stroke, aneurysms, and vascular malformations. As a result, noninvasive CT- and MRI-based techniques have been increasingly used in emergency settings. In this context, neurovascular imaging has become an essential part of the curriculum for training emergency radiologists, stroke neurologists, and vascular neurosurgeons. This book provides a comprehensive review of the entire spectrum of emergent neurovascular imaging, with the emphasis on noninvasive CT angiography (CTA), MR angiography (MRA), and perfusion techniques. It is organized into 11 chapters. The first three chapters address the topics of acute stroke imaging, including algorithms based on recent clinical trials and updated American Heart Association stroke guideline, vascular territories, and stroke mimics. These are followed by discussions of cerebrovenous thrombosis, vasculopathies, aneurysms, and vascular malformations. Remaining chapters are devoted to the traumatic neurovascular injury, as well as the relatively rare albeit important topics of head and neck vascular emergencies and spinal vascular diseases. The book has an image-rich format, including more than 300 selected CT, MRI, or digital subtraction angiography (DSA) images. Atlas of Emergency Neurovascular Imaging is an essential resource for physicians and related professionals, residents, and fellows in emergency medicine, neuroradiology, emergency imaging, neurology, and vascular neurosurgery and can successfully serve as a primary learning tool or a quick reference guide.