Search

The new edition of this popular book brings together experts in the field of Systems Neuroscience to present an overview of the area. Topics covered include how different neural circuits analyze sensory information, form perceptions of the external world, make decisions, and execute movements; how nerve cells behave when connected together to form neural networks; the relationship between molecular and cellular approaches to understanding brain structure and function; the study of high-level mental functions; and studying brain pathologies and disease. Among the topics covered in the new edition are artificial intelligence-assisted computational neuroscience for deciphering neural networks, spatial transcriptomics single cell sequencing, and exome/whole genome sequencing for understanding brain disorders in human genetics. The best way to study the brain, the most complex organ in the body composed of 100 billion neurons with trillions of interconnections, is with a systems biology approach.

This book is a comprehensive reference of the neuraxial route for the delivery of therapeutics. It reviews the historical evolution of this approach from its inception in the later 1800's to present day. This amply referenced text covers basic discussions of spinal anatomy, embryogenesis, neuraxial vascularity, cerebrospinal fluid flow dynamics and parenchymal molecule movement. The pharmacokinetic and pharmacodynamic properties of different intrathecal agents are explored in detail with particular reference to clinical correlates in pain and spasticity. Particular attention is paid to the issues relevant to preclinical models of intrathecal delivery and the assessment of spinal pathologies arising from acute and chronic intrathecal drug delivery. Chapters provide essential discussions of clinical aspects of patient care, including patient evaluation and screening, trialing and device management, troubleshooting problems and addressing complications, best practices, cost-effectiveness and future of the therapy. Clinicians and researchers who practice intrathecal therapy and study neuraxial mechanisms will find Neuraxial Therapeutics, to be an invaluable guide to this treatment modality.

Nanotechnology is believed to accelerate our fight to sustain and enhance crop productivity for the ever-increasing world population. It has been reckoned as one of the safest and most cost-efficient techniques to boost crop productivity in the future. The ever-increasing state-of-the-art availability of various nanomaterials has allowed us to pursue their beneficial properties in agronomy. Nanotechnology will help minimize the dependency on chemical fertilizers and existing crop production techniques that have already been exploited to their maximum potential. Therefore, in the present context, it could well be realized that agriculture will be driven by nanotechnology in the future.This book focuses on the application of nanotechnology for enhancing crop production through the application of nanofertilizers or nanocomposites. Several avenues of nanotechnology are beneficial in improving crop productivity in a sustainable manner, which has been presented in a comprehensive way. The book also delves into the mechanistic view of nanoparticle functioning and its role in stress alleviation. In addition, the book presents some recent insights into the application of nanotechnology for post-harvest management, stress tolerance and usage as nanobiosensors.Broadly, the book will encompass the following advances in the field, distinguishing it from other published volumes. The salient features include:· Role of nanoparticles in improving abiotic stress tolerance in plants.· Role of nanoparticles in protection against pathogens and pests.· Mechanism of nanoparticle-induced plant responses.· Synthesis and modification of nanoparticles to enhance their biological efficacy.· Prospects of nanofertilizers, nanoformulations, nanopesticides, etc., and their beneficial attributes.This book, therefore, presents this emerging topic and the most recent innovations in this field for postgraduate students, researchers and faculty members working in the fields of plant science, microbiology, biotechnology, agricultural sciences, etc.

Carbon-Based Nanomaterials in Biosystems: Biophysical interface at Lower Dimensions provides a thoroughly comprehensive overview of all major aspects of carbon-based nanomaterials, their biophysical response, and biotechnological application. The book articulates the underlying physics, chemistry, and the basic phenomenon of the broad-range carbon-based nanomaterials (CNMs) with the biological systems particularly the interface analysis. Organized in six sections, it discusses state-of art technological interventions of carbon-based nanomaterials and their application in biomedical sectors in healthcare, food sciences, and technology. The book also highlights the carrying capacity of different CNMs in payload efficiency mechanisms in various biomedical fields. The theranostic efficiency and the safety of various forms of CNMs is assessed. Carbon-Based Nanomaterials in Biosystems is a helpful resource to those specializing in the areas of nanomedicine, bionanomaterials and nanotechnology applications. - Covers major breakthroughs in carbon nanomaterials (CNMs) - Distinguishes between the advantages and disadvantages of carbon-based and non-carbon-based nanomaterials - Discusses the significance of different forms of carbon nanomaterials and their unique physico-chemical and electrochemical properties at the lower dimension - Examines the appropriate methodologies for tackling safety and health-related matters while using carbon-based nanomaterials - Discusses recent developments of various forms of carbon-based nanomaterials such as graphene, carbon nanotubes, fullerenes, and carbon nano-onions

Nanoferrites for Emerging Environmental Applications discusses the synthesis and structure of nanoferrites, as well as their electrical, optical, and magnetic properties. This book also provides a detailed discussion of the use of nanoferrites for various environmental applications, such as for water and air pollution detection and remediation. This book covers almost every aspect of nanoferrites for environmental applications and will be of great use to researchers working in multidisciplinary areas. Nanoferrites'superior electronic, optical, and magnetic properties make them promising agents in a wide spectrum of applications. After looking at the fundamentals of nanoferrites, this book proceeds to analyze their application in a comprehensive range of environmental applications. Topics covered include wastewater treatment, the removal of heavy metal ions, remediation of organic and inorganic pollutants, and their use in the detection and remediation of both air and solid pollution. Future opportunities for research are also addressed. - Focuses on nanoferrite applications for air and water pollution detection, and remediation through purification - Includes detailed synthesis procedures and advanced characterization methods for nanoferrites - Explores ways that nanoferrites can be used in various environmental applications and then be recovered after use

Bionanomaterials for Industrial Applications is a comprehensive guide to the current state of bionanomaterials research and their prospective applications in a variety of industrial sectors. The book discusses the properties of bionanomaterials, types and their potential applications in various disciplines, such as biomedicine, food industry, environment, etc. It provides a comprehensive overview of the current state of bionanomaterials research and their potential applications, making it an indispensable resource for anyone interested in learning more about this dynamic and rapidly developing field.Features: Discusses properties, classifications, and synthesis of bionanomaterials in addition to industrial applications Covers circular economy and life cycle assessment of bionanomaterials Explores impact of bionanomaterials on environment and human health Includes individual chapters specifically focusing on a particular application of bionanomaterials Reviews detailed industrial applications in particular field viz. environmental, food sciences, biomedical, and so forth This book is designed for researchers, scientists, engineers, and graduate students working in the field of bionanomaterials, as well as industrial professionals who could benefit from the use of bionanomaterials.

One of the recent advances in 21st century medicine is the emergence of gene therapies, drugs that affect the basic biology of genetic disease. The field has seen some notable setbacks in the past, but in recent years has exploded as decades of basic science have been successfully translated into the most complex biologics ever constructed, leading to regulatory approval of several gene therapy products in oncology, hematology, neurology, and ophthalmology indications. These drugs are at the apex of biological manufacturing complexity, and have the potential to be disease modifying or even curative. Evidence-based and innovative quantitative clinical development and lifecycle management strategies will be required as fixtures in the development for these unique drugs in order to reach patients in need.Development of Gene Therapies: Strategic, Scientific, and Regulatory Considerations is an unparalleled summary of the current scientific, statistical, developmental, and regulatory aspects of gene therapies, which is fast becoming a core area of the biopharmaceutical industry. This edited volume provides a systematic description of core development topics in gene therapies through 19 peer-reviewed chapters written by subject matter experts in the field.This edited volume is an invaluable resource for business leaders and investors hoping to understand the scientific principles and strategy of a company they may potentially invest in; the family members of someone affected by a genetic disease who wish to understand better how these therapies work and what they might expect as a treatment for a loved one; academic professionals, who want to learn and teach incoming medical, public health, or business students; and seasoned drug developers, who wish to learn more about the about the cutting edge of biopharmaceutical drug development.Key Features: Provides a thorough background on the scientific, manufacturing, and translational concepts and competencies for gene therapies. Covers important strategic aspects of the gene therapy industry, thereby helping investors, drug developers, and regulators gain a better appreciation of the potential value of gene therapies. Expounds on many existing and emerging state-of-the art scientific and technological advances, as well as ethical, pharmacovigilance, and regulatory considerations for gene therapy product development. Presents several case studies of successful development of gene therapies, including two of the most remarkable FDA-approved gene therapy products: Zolgensma and Luxturna. Provides perspectives and forward-looking statements on the future of gene therapies in neurological, in utero, and ultra-rare indications.

This new volume discusses a selection of nanomaterials that can be employed for advanced biological, nutraceutical, and medicinal applications. It discusses diverse nanomaterials and their classifications, their advanced therapeutic properties, using biosensors in detecting biological threat agents, bionanomaterials for human health, the medicinal applications of nanomaterials, clinical toxicities of nanomaterials and their use in remediation.The book also includes a chapter that provides a helpful comparison of market analysis between biological and synthetic nanomaterials. The volume concludes with an insightful perspective on possible future applications of nanomaterials as nutraceutical, biological, and medicinal agents.

In den letzten zehn Jahren hat sich die Gentherapie als eine bahnbrechende neue Behandlungsoption entwickelt, insbesondere durch die Zulassung von Produkten für die Hämophilie A und B. Diese Therapieform verspricht eine weitgehende Unabhängigkeit von regelmäßiger Substitutionstherapie bei niedrigen Blutungsraten, dank der Verwendung von adeno-assoziierten Viren (AAV) als Vektoren. Das vorliegende Buch vermittelt die aktuellen Kenntnisse zum Potenzial der neuen Gentherapeutika in der Behandlung von Hämophilie A und B. Es deckt dabei ein breites Spektrum ab: von den Grundlagen der Hämophilie über die verschiedenen gentherapeutischen Ansätze (AAV, Lentivirus, Gene Editing) bis hin zu spezifischen Aspekten wie der Auswahl geeigneter Patienten für die Gentherapie, den Auswirkungen auf Gerinnungsfaktorwerte, leberbezogenen Fragestellungen und der Immunantwort auf AAV-vermittelte Gentherapie. Es erläutert außerdem die Notwendigkeit einer interdisziplinären Zusammenarbeit und diskutiert das innovative “Hub and Spoke”-Modell. Dieses Buch soll als Brücke dienen, die die Lücke zwischen dem aktuellen Wissenstand und zukünftigen Entwicklungen schließt, und es zielt darauf ab, eine umfassende Informationsquelle für Fachleute in der klinischen Praxis und Forschung zu sein.

Drug Development for Gene Therapy Industry-centric perspective on translational and bioanalytical challenges and best practices for gene therapies Drug Development for Gene Therapy focuses on the translational and bioanalytical challenges and best practices for gene therapy modalities, presenting a significant body of data, including information related to safety and efficacy, necessary to advance through the development pipeline into clinical use. The text covers bioanalytical methods and platforms including patient screening assays, different PCR tests, enzyme activity assays, ELISpot, NGS, LC/MS, and immunoassays, with FDA and EMA guidelines on gene therapy safety and efficacy, along with companion diagnostics regulations from US and EU perspectives. The chapters offer an in-depth discussion of the basics and best practices for translational biomarkers, bioanalysis, and developing companion diagnostics / lab tests for gene therapies in the pharma and biopharma industries. To aid in reader comprehension, the text includes clinical examples of relevant therapies in related chapters. Some of the core topics covered include study design, immunogenicity, various bioanalytical methods and their applications, and global regulatory issues. Written by two highly qualified authors with significant experience in the field, Drug Development for Gene Therapy includes information on: Bioanalytical methods to detect pre-existing antibodies against adeno-associated viruses (AAV) capsids Detection of cellular immunity and humoral response to viral capsids and transgene proteins, and immunogenicity of gene therapy products Nonclinical and clinical study considerations and methods for biodistribution and shedding Quantification of transgene protein expression and biochemical function, and substrate and distal pharmacodynamic biomarker measurements for gene therapy Detection and quantification of rAAV integration and off-target editing Current regulatory landscape for gene therapy product development and the role of biomarkers and general regulatory considerations for gene therapy companion diagnostics With comprehensive coverage of the subject, Drug Development for Gene Therapy is a must-have resource for researchers and developers in the areas of pharmaceuticals, biopharmaceuticals, and contract research organizations (CROs), along with professors, researchers, and advanced students in chemistry, biological, biomedical engineering, pharmaceuticals, and medical sciences.

A asma é uma doença inflamatória crônica que acomete os pulmões, muitas vezes associada a um processo de remodelamento com obstrução das vias aéreas e comprometimento da ventilação pulmonar. Até o momento, não há tratamento capaz de reverter ou minimizar tais alterações estruturais, sendo necessária a busca por novas estratégias terapêuticas. A terapia gênica surge como uma alternativa promissora para o tratamento de doenças respiratórias, pois o pulmão é um órgão de fácil acesso. O fator derivado do epitélio pigmentado (PEDF) possui atividades antiangiogênicas, anti-inflamatórias e antifibróticas e seria promissor para o tratamento de doenças inflamatórias que acometem os pulmões. Portanto, a terapia gênica com AAV8-hPEDF e PEG-PBAE-hPEDF é promissora para o tratamento da asma alérgica, fornecendo meios de reverter o remodelamento da asma e, potencialmente, outras doenças pulmonares que cursem com inflamação e fibrose.

This book contains the proceedings of the XVIII International Symposium on Retinal Degeneration (RD2018). A majority of those who spoke and presented posters at the meeting contributed to this volume. The blinding diseases of inherited retinal degenerations have no treatments, and age-related macular degeneration has no cures, despite the fact that it is an epidemic among the elderly, with 1 in 3-4 affected by the age of 70. The RD Symposium focused on the exciting new developments aimed at understanding these diseases and providing therapies for them. Since most major scientists in the field of retinal degenerations attend the biennial RD Symposia, they are known by most as the “best” and “most important” meetings in the field.The volume presents representative state-of-the-art research in almost all areas of retinal degenerations, ranging from cytopathologic, physiologic, diagnostic and clinical aspects; animal models; mechanisms of cell death; candidate genes, cloning, mapping and other aspects of molecular genetics; and developing potential therapeutic measures such as gene therapy and neuroprotective agents for potential pharmaceutical therapy. While advances in these areas of retinal degenerations were described, there will be many new topics that either are in their infancy or did not exist at the time of the last RD Symposium. These include the role of inflammation and immunity, as well as other basic mechanisms, in age-related macular degeneration, several new aspects of gene therapy, and revolutionary new imaging and functional testing that will have a huge impact on the diagnosis and following the course of retinal degenerations, as well as to provide new quantitative endpoints for clinical trials. The retina is an approachable part of the central nervous system (CNS), and there is a major interest in neuroprotective and gene therapy for CNS diseases and neurodegenerations, in general. It should be noted that withsuccessful and exciting initial clinical trials in neuroprotective and gene therapy, including the restoration of sight in blind children, the retinal degeneration therapies are leading the way towards new therapeutic measures for neurodegenerations of the CNS. Many of the successes recently reported in these areas of retinal degeneration sprang from collaborations established at previous RD Symposia, and many of those were reported at the RD2016 meeting and included in the current volume. We anticipate the excitement of those working in the field and those afflicted with retinal degenerations is reflected in the volume.

Treatment Landscape of Targeted Therapies in Oncology: Challenges and Opportunities provides up-to-date knowledge on antitumor-targeted therapies and immunotherapy. The book's chapters are written by researchers dynamically working/focusing on cancer treatment. The content is designed to help those who are new to the field (beginners) and various specialized scientists and researchers involved in cancer research. For decades, the hallmark of cancer treatment has been conventional chemotherapy. But with the rapid increase in our understanding of the immune system, more and more small molecules, peptides, recombinant antibodies, vaccines and cellular therapeutic modalities are being applied to manipulate the immune response for cancer treatment. - Covers basic concepts and updated knowledge of the latest anticancer drugs - Brings comprehensive understanding of the treatment of cancer in context of immunotherapy and targeted therapy - Introduces the latest drugs and advancements in the treatment of cancer - Includes detailed diagrams to give insight to the mechanisms of action

Sinusoidal Cells in Liver Diseases: Role in their Pathophysiology, Diagnosis, and Treatment provides a state-of-the-art review on recent advances surrounding the role of liver sinusoidal cells (LSECs, HSCs, macrophages, and other non-parenchymal cells) in acute and chronic liver diseases. Coverage emphasizes disease pathophysiology, novel mechanisms, unmet clinical questions, development of biomarkers and treatment opportunities. By focusing on the role of sinusoidal cells in human liver diseases, this reference provides a comprehensive overview of the role of sinusoidal cells in acute and chronic liver diseases, in its pathophysiology and mechanisms, and in the development of novel biomarkers and new therapeutics. Cells of the liver vasculature play an essential role in the pathophysiology of acute and chronic liver diseases and are considered key therapeutic targets to treat most of human hepatopathies. Coverage in this reference includes the phenotypic changes occurring in liver vascular cells and how cells contribute to the development of microcirculatory dysfunction, fibrosis, inflammation, and liver failure. Provides a comprehensive update on the role of sinusoidal cells in acute and chronic liver diseasesCovers our current understanding of the role of sinusoidal cells as therapeutic targets to improve liver diseasesPresents the latest research in the development of novel biomarkers of liver diseases that derive from sinusoidal cells

Navigating Non-coding RNA: From Biogenesis to Therapeutic Application provides a concise overview of the field of non-coding RNA (ncRNA). Chapters cover the history of discoveries that have occurred in the area of ncRNA, specific types of ncRNA, housekeeping ncRNAs such as ribosomal RNA, transfer RNA, small nuclear RNA and telomerase RNA, regulatory ncRNAs such as microRNA, small interfering RNA, long non-coding RNA and Y RNA. Biogenesis, structure, function, and regulation of each of these are also explored in addition to traditional and cutting-edge methods for the identification, functional characterization and structural characterization of ncRNA. The book also focuses on the different types of epitranscriptomic modifications and their involvement in regulating ncRNA structure, stability and intermolecular interactions in addition to the role of ncRNAs in a range of diseases and potential therapeutic applications. - Covers a wide range of non-coding RNAs, including ribosomal RNA, transfer RNA, telomerase RNA, microRNA, small interfering RNA and circular RNA - Features both traditional and novel methodologies for investigating ncRNA, from microarray and conventional chemical probing to CAGE-seq and computational methods - Includes chapters on ncRNAs in a range of diseases, including cancers, neurological disorders, cardiovascular conditions and infectious illnesses - Discusses novel therapeutic strategies for targeting ncRNAs, including CRISP/Ca9 applications and RNAi-based strategies - Explores the molecular mechanisms and intermolecular interactions of ncRNA

HUMAN-MACHINE INTERFACE The book contains the latest advances in healthcare and presents them in the frame of the Human-Machine Interface (HMI). The Human-Machine Interface (HMI) industry has witnessed the evolution from a simple push button to a modern touch-screen display. HMI is a user interface that allows humans to operate controllers for machines, systems, or instruments. Most medical procedures are improved by HMI systems, from calling an ambulance to ensuring that a patient receives adequate treatment on time. This book describes the scenario of biomedical technologies in the context of the advanced HMI, with a focus on direct brain-computer connection. The book describes several HMI tools and related techniques for analyzing, creating, controlling, and upgrading healthcare delivery systems, and provides details regarding how advancements in technology, particularly HMI, ensure ethical and fair use in patient care. Audience The target audience for this book is medical personnel and policymakers in healthcare and pharmaceutical professionals, as well as engineers and researchers in computer science and artificial intelligence.

INTEGRATION OF BIOMATERIALS FOR GENE THERAPY Brings industrial practitioners and researchers together to discuss how the deeper integration of biomaterial platforms could play a significant role in enabling breakthroughs in the application of gene editing for the treatment of human disease. This book comprises research and review articles from leading researchers with multidisciplinary experience. It discusses many broad topics, including nanoparticle-enabled gene therapy, inorganic nanocarrier-based gene delivery, non-viral delivery of nucleic acid, biocompatible hydrogels, silk, and polysaccharides-based gene delivery. Other gene delivery topics discussed include the use of smart and engineered biomaterials, combined therapy with growth factors and cell transportation, and the prospects and challenges in the treatment of different diseases, including cancer. This book bridges the knowledge of pharmaceutics, engineering, basic science, and clinical research fields in a way that will help the research community expedite the clinical application of these therapies for various diseases and conditions. Audience A broad range of researchers, scientists, and engineers in diverse fields such as materials science, biomedicine, biomedical engineering, biology, chemistry, physics, biotechnology, pharmacology, toxicology, and formulation scientists.

This volume of 30 chapters contributed by reputed authors covers: Diversification of livestock and crops. Integration of livestock systems with forestry and crop production. Drought and heat wave tolerant varieties. Strategies for reduction of Green House Gases emission from ruminants. Application of GIS and remote sensing technologies. Breeds with inherent genetic capabilities to adapt to climate change. This book also takes into account the climate change adaptation, mitigation practices, and policy frameworks for promotion of sustainable livestock and poultry production.This book is co-published with NIPA. Taylor and Francis does not sell or distribute its print and electronic editions in India, Pakistan, Nepal, Bhutan, Bangladesh and Sri Lanka.

This contributed volume is dedicated towards the progress achieved within the last years in all areas of Cell Culture Engineering and Technology. It comprises contributions of active researchers in the field of cell culture development for the production of recombinant proteins, cell line development, cell therapy and gene therapy, with consideration of media development, process scale-up, reactor design, monitoring and control and model-assisted strategies for process design. The knowledge and expertise of the authors cover disciplines like cell biology, engineering, biotechnology and biomedical sciences. This book is conceived for graduate students, postdoctoral fellows and researchers interested in the latest developments in Cell Engineering.

This book illuminates a few highly significant events in history in which astronomers have helped keep contacts between astronomers of different states in moments of international political tensions or even crises. The chapters, written by 20 international authors, focus on four periods where astronomers were particularly active in international relations:1. The WWI period, the epoch of the creation of the IAU, in the context of the simultaneous creation of other scientific unions. The book also singles out the important role of A.S. Eddington and his network “across forbidden borders”.2. The Cold war period and its consequences, when several countries were divided between opposite blocs. “The China crisis” is told here from different viewpoints by Chinese astronomers, both from the mainland and from Taiwan, in parallel with the evolution of astronomy in South and North Korea. Germany's twisted path in its membership of the IAU, from its admission in 1951 to its reunification in 1991 is shown as another example.3. The book then highlights a third period, when radio astronomers, in particular, were very active in “building bridges” between East and West. It also tells the history of how the apparently innocuous issue of the “lunar nomenclature” became extremely sensitive. The part ends on two chapters on Russian robotic missions and lunar surface features as well on the Russian participation in the “International Virtual Observatory” project.4. The fourth part reports for the first time on the “hidden story” of the relations between the IAU and the United Nations after the “Moon race” when the United Nations decided to challenge the IAU's authority on “extraterrestrial names”. The final chapter reviews how twenty years later UNESCO and the IAU had become strong partners in the difficult, but highly successful organization of the International Year of Astronomy (2002-2009), and of the “Astronomy and World Heritage” intitiative (2008).

This book aims to address cutting-edge progress in the area of synthesisand biomedical applications of magnetic nanomaterials. It compiles a broadspectrum from fundamental principles to technological advances, from synthesisand modification to biomedical applications along with biocompatibility. Themain topics include principles in nanomagnetism, technologies for magneticnanomaterials fabrication, developments in their biomedical applications, andthe challenges in the toxicity in clinical translation. The first partintroduced the principles of nanomagnetism and specific properties in magnetic nanomaterials.Then, some typical fabrication strategies in magnetic nanomaterials forcontrolled composition, morphologies and sizes are reviewed; and surfacemodification methods with better hydrophilcity and biocompatibility arepresented. Next, magnetic nanomaterials-based applications in biomedical fieldare highlighted in detail, mainly including magnetic resonance image, magnetic hyperthermia,cancer therapy, multi-mode imaging, imaging-guided therapy and manipulatebiological objects. Finally, biocompatibility issues caused by magneticnanomaterials are also overviewed.

This second edition is written for the primary care clinician to help update knowledge of pediatric nephrology. The current and future shortage of pediatric nephrologists necessitates steady, rejuvenated information on the Aristolean kidney for primary care clinicians as they care for the child and adolescent with renal and genitourinary dilemmas and disorders. In view of this shortage and the rapidly increasing knowledge in pediatric nephrology as well understanding indications for referral to pediatric nephrologists in the 21st century, au courant assiduous information aimed at primary care clinicians in these areas becomes increasingly important. Chapters in this book cover nephrological problems in different pediatric ages including newborns. As noted by some of the ancient scholars, the kidney does not exist in isolation, but is involved in other aspects of the body – thus, we include chapters on the kidney in cardiac and other disorders. Behavioral aspects of chronic disease, including renal disorders, are also considered because of the importance that renal (and chronic) disease has on the child and adolescent.

Bundled with the eBook, which will be updated regularly as new information about each virus is available, this text serves as the authoritative, up-to-date reference book for virologists, infectious disease specialists, microbiologists, and physicians, as well as medical students pursuing a career in infectious diseases.

Post-transcriptional Gene Regulation in Human Disease, a new volume in the Translational Epigenetics book series, offers a thorough overview and discussion of post-transcriptional genetic control mechanisms and their roles across various pathologies and human developmental outcomes, along with regulatory mechanisms targeted for therapeutic approaches. The book is broadly divided in two parts: early chapters describe the basics of post-transcriptional gene regulation, associated epigenetic mechanisms, the role of RNA binding proteins, the evolution of post-transcriptional gene regulation, and methods to study these mechanisms. The second half of the book includes deeper discussion of post-transcriptional gene regulation across specific diseases and therapeutics targets. Various post-transcriptional events, including alternative splicing and polyadenylation, mRNA stability, and miRNAs and their involvement in the disease progression, are examined in detail. - Includes full-color imagery illustrating key concepts and post-transcriptional disease processes, as well as descriptions of methods for studying post-transcriptional gene regulation - Presents fundamental knowledge, molecular and biochemical mechanisms, and recent findings in concise and easily understandable formats - Features a summary and conclusion at the end of each chapter

This book is a compendium of key scientific questions, challenges, and opportunities across different areas of exoplanetary science. The field is currently experiencing rapid growth, and the book provides a front-row view of the advancements at the cutting-edge of the field. Each chapter contains a short exposition on the most important open questions, challenges, and opportunities in a specific area from the perspective of one or more top experts in the area. It provides a starting point for researchers, experts and non-experts alike, to obtain a quick overview of the forefront of exoplanetary science and a vision for the future of the field. Topics range from observational developments and techniques, including exoplanet detection and characterisation methods and state-of-the-art and future missions, to exoplanet theory and modelling including planet formation, planetary interiors, atmospheres, habitability and the search for life. Key Features Provides a close-up view of the frontiers of exoplanetary science researchSummarises key questions, challenges, and opportunities across different areas of the fieldWritten by leading experts in the fieldProvides a valuable reference for early career researchersTopics span from state-of-the-art and emerging areas to long-term future directions

Magnetic Nanoparticle-Based Hybrid Materials: Fundamentals and Applications introduces the principles, properties, and emerging applications of this important materials system. The hybridization of magnetic nanoparticles with metals, metal oxides and semiconducting nanoparticles may result in superior properties. The book reviews the most relevant hybrid materials, their mechanisms and properties. Then, the book focuses on the rational design, controlled synthesis, advanced characterizations and in-depth understanding of structure-property relationships. The last part addresses the promising applications of hybrid nanomaterials in the real world such as in the environment, energy, medicine fields. Magnetic Nanoparticle-Based Hybrid Materials: Fundamentals and Applications comprehensively reviews both the theoretical and experimental approaches used to rapidly advance nanomaterials that could result in new technologies that impact day-to-day life and society in key areas such as health and the environment. It is suitable for researchers and practitioners who are materials scientists and engineers, chemists or physicists in academia and R&D. - Provides in-depth information on the basic principles of magnetic nanoparticles-based hybrid materials such as synthesis, characterization, properties, and magnon interactions - Discusses the most relevant hybrid materials systems including integration of metals, metal oxides, polymers, carbon and more - Addresses the emerging applications in medicine, the environment, energy, sensing, and computing enabled by magnetic nanoparticles-based hybrid materials

This book is based on the principles, limitations, challenges, improvements and applications of nanotechnology in medical science as described in the literature. It highlights various parameters affecting the synthesis of bio-nanomaterials and exclusive techniques utilized for characterizing the nanostructures for their potential use in biomedical and environmental applications. Moreover, biodegradable synthesis of nanomaterials is regarded as an important tool to reduce the destructive effects associated with the traditional methods of synthesis for nanostructures commonly utilized in laboratory and industry and as well as academic scale of innovative research foundation.

This book provides a comprehensive overview of the biology of the endoplasmic reticulum (ER) and the associated ER proteins, it discusses their structure, function and signaling mechanisms in the cell and their role in disease. This book also offers insights into the practical aspects of research and demonstrates the use of non-mammalian models to study the structure and function of the ER. Written by leading experts in the field, the book enables readers to gain a thorough understanding of current ER biology. It is intended for scientists and clinical researchers working on the endoplasmic reticulum in all its various roles and facets in health and disease.

This volume, comprising 30 chapters authored by distinguished experts, encompasses the following topics: 1. Diversification of livestock and crops. 2. Integration of livestock systems with forestry and crop production. 3. Heat and drought-tolerant varieties. 4. Strategies for reducing greenhouse gas emissions from ruminants. 5. Applications of geographic information systems (GIS) and remote sensing technologies. 6. Breeds with inherent genetic capabilities to adapt to climate change. 7. Climate change adaptation and mitigation practices. 8. Policy frameworks for promoting sustainable livestock and poultry production.

The book An Introduction to Drug Carriers provides a broad overview of drug carriers. Drug carriers play medically important roles in delivering drugs to pinpointed regions in biological systems. The cell hosts most of the disorders related to diseases. Therefore, the cell is also considered the main target region for most drugs. Some of the cellular compartments, especially cell-based membranes, which are geometrically constructed with both hydrophobic and hydrophilic layers/boundaries, often appear as barriers against vital candidate drugs'journey to the target regions. Besides, there are off-target structures that need to be avoided for drugs to get adsorbed. Otherwise, drugs may cause unbearable off-target binding originated toxicity, which would reduce the efficacy of the drugs. Appropriate choice of drug carriers may help specific drugs to get conjugated and be delivered to their optimal target structures. Biophysical and biochemical characterization of drug carriers concerning their role as vehicles to carry certain drugs may be obtained using engineering techniques. Manipulation in the cellular sites that cause disturbances in drug delivery is another biomedical option utilized to ensure smooth drug delivery. Various theoretical and experimental techniques are utilized to address all these issues related to drug carriers. The collected chapters written by experts in the field will help the subject matter be understood thoroughly.

Almost all galaxies host in their center a supermassive black hole of mass between a million and tens of billions solar masses. Supermassive black holes grow in symbiosis with their host galaxies across the Hubble time, occasionally accreting surround matter, giving rise to an Active Galactic Nuclei (AGN). This book gives a general review of our current knowledge of AGN, powered by supermassive black holes: how they are fueled by gas (or stars) and what problems are encountered; how can we account for the wide variety of AGN, from Seyfert/Liners to quasars, and for the two types (AGN 1 and 2) either through dust obscuration, and geometrical orientation arguments, or through intrinsic activity difference, qualitative or quantitative. With modern instruments, providing high resolution and sensitivity, like ALMA in radio, or MUSE at the ESO/VLT, it is possible to unveil the interstellar medium and stars in the circumnuclear regions, discover molecular disks and tori, in the sphere of influence of the black holes. While AGN are accreting matter, they are providing so much energy that part of the surrounding gas is expelled and is observed in molecular outflows, identified as the main feedback process of AGN on their host.Key Features:Reviews our current knowledge of AGN, with case studies and examples of observed AGN in their host galaxies.Discusses the long-standing problem of AGN fueling and feedback, and proposes educated models of the circum-nuclear regions, which are still difficult to resolve.Covers recent advances in the field of AGN research provided by current astronomical instrumentation (e.g., ALMA, VLT).Written by a world-leading expert in the field.

Handbook on Biological Warfare Preparedness provides detailed information on biological warfare agents and their mode of transmission and spread. In addition, it explains methods of detection and medical countermeasures, including vaccine and post-exposure therapeutics, with specific sections detailing diseases, their transmission, clinical signs and symptoms, diagnosis, treatment, vaccines, prevention and management. This book is useful reading for researchers and advanced students in toxicology, but it will also prove helpful for medical students, civil administration, medical doctors, first responders and security forces. As the highly unpredictable nature of any event involving biological warfare agents has given rise to the need for the rapid development of accurate detection systems, this book is a timely resource on the topic. - Introduces different bacterial and viral agents, including Ebola and other emerging threats and toxins - Discusses medical countermeasures, including vaccines and post-exposure therapeutics - Includes a comprehensive review of current methods of detection

British agent Joe Wilderness returns in “Lawton's ongoing recreation of Cold War chicanery... one of the great pleasures of modern spy fiction” (Mick Herron, award-winning author of the Slough House series). It's London, the swinging sixties, and by all rights, MI6 spy Joe Wilderness should be having as good a time as James Bond. But alas, his postings are more grim than glamorous. In the wake of an embarrassing disaster for MI6 in a divided Berlin, Wilderness is reprimanded with a posting to remote northern Finland under the guise of a cultural exchange program to promote Britain abroad. Bored by his work, with nothing to spy on, Wilderness strikes a deal with his old KGB pal Kostya to smuggle vodka into the USSR. But there is something fishy about why Kostya has suddenly turned up in Finland—and MI6 intelligence from London points to a connection with cobalt mining in the region, a critical component in the casing of the atomic bomb. Wilderness's posting is getting more interesting by the minute, but more dangerous too. Moving from the no-man's-land of Cold War Finland to the wild days of the Prague Spring, and populated by old friends—including Inspector Troy—and old enemies alike, Hammer to Fall is a gripping tale of deception and skullduggery, of art and politics—a page-turning story of the always-riveting life of the British spy. “Lawton scores another hit.” —Publishers Weekly (starred review) “A jaw-dropping finale that will leave readers palpitating for more.” —Booklist (starred review) “A terrific thriller: fun, satisfying, and humane.”—Kirkus Reviews (starred review)

This new book, Nanobiotechnology: Concepts and Applications in Health, Agriculture, and Environment, presents a broad conceptual overview regarding the synthesis, applications, and toxicological aspects of nanobiotechnology. It focuses on the entrance into and interaction of nanomaterials in the human body, which has generated intense scientific curiosity, attracting much attention as well as increasing concern from the nanomaterial-based industries and academia across the world.This book looks at the scientific aspects of nanomaterials used in many applications of biosciences, taking an interdisciplinary approach that encompasses medicine, biology, pharmacy, physics, chemistry, engineering, nanotechnology, and materials science. The volume covers the basics of nanosciences and nanotechnology; different schemes and routes of synthesis; and various biological applications, including sensing, medicine, drug delivery systems, and remediation. Further, special chapters will be devoted to nanotoxicology and the developing risk factors associated with nanosized particles during use along with the ethical issues related to nanobiotechnology.

It's London, the swinging sixties, and by rights MI6 spy Joe Wilderness should be having as good a time as James Bond. But alas, in the wake of an embarrassing disaster for MI6, Wilderness has been posted to remote northern Finland in a cultural exchange program to promote Britain abroad. Bored by his work, with nothing to spy on, Wilderness finds another way to make money: smuggling vodka across the border into the USSR. He strikes a deal with old KGB pal Kostya, who explains to him there is a vodka shortage in the Soviet Union - but there is something fishy about Kostya's sudden appearance in Finland and intelligence from London points to a connection to cobalt mining in the region, a critical component in the casing of the atomic bomb. Wilderness's posting is getting more interesting by the minute, but more dangerous too. Moving from the no-man's-land of Cold War Finland to the wild days of the Prague Spring, and populated by old friends (including Inspector Troy) and old enemies alike, Hammer to Fall is a gripping tale of deception and skulduggery, of art and politics, a page-turning story of the always riveting life of the British spy.

Set to generate and influence discussions in the field for years to come, this is an encyclopaedic work on the ever-evolving genre of poetry film. It will set the benchmark for all subsequent works on the subject, being the first book of its kind. Poetry films are a genre of short film, usually combining the three main elements: the poem as verbal message; the moving film image and diegetic sounds; and additional non-diegetic sounds or music, which create a soundscape. This book examines the formal characteristics of the poetic in poetry film, film poetry and video poetry, particularly in relation to lyric voice and time. Provides an introduction to the emergence and history of poetry film in a global context, defining and debating terms both philosophically and materially. Examines the formal characteristics of the poetic in poetry film, particularly in relation to lyric voice and time. Includes interviews, analysis and a rigorous and thorough investigation of the poetry film from its origins to the present. This is a very important, groundbreaking work on film poetry. The ideas discussed here are of great importance, and the diversity and breadth of the volume is especially impressive and very useful. This book brings together in one place crucial ideas and information for practitioners, students and academics, and is clearly and accessibly written. Including over 40 contributors and showcasing the work of an international array of practitioners, this will be an industry bible for anyone interested in poetry, digital media, filmmaking, art and creative writing, as well as poetry filmmakers. It explores working practices, processes of collaboration and the mechanisms which make these possible. It also reveals the network of festivals disseminating and theorizing poetry film and presents a compelling bibliography. This is the most incisive and complete analysis of filmic poetry to date. It is poised to become a major text in the field. Essential reading for academics teaching poetry filmmaking, moving image, film, media and media poetry, writing and art. Undergraduate and postgraduate students in those fields. Great potential for textbook adoption. Also relevant to poets, filmmakers, visual artists, graphic artists and theorists, filmmakers, screenwriters, art historians, philosophers, cultural commentators, arts journalists.

This book is written for health care professionals to help update knowledge of pediatric cardiology from the Aristotelean heart era and particularly from the past several decades. The current and future shortage of pediatric cardiologists necessitates steady, rejuvenated information on the Aristotelean heart for primary care clinicians as they care for the child as well as adolescent/young adult with cardiovascular dilemmas and disorders. In view of this shortage and the rapidly increasing knowledge in pediatric cardiology as well as understanding indications for referral to pediatric cardiologists in the 21st century, au courant assiduous information aimed at primary care clinicians in these areas becomes increasingly important. Chapters in this book cover cardiologic problems in different pediatric ages from newborns to young adults. We begin with a history of medical knowledge regarding the heart starting when writing began in ancient Mesopotamia to our current understanding that is subject to further change with ongoing insight and research from current as well as future scholars.

Now in its fifth edition, Principles of Tissue Engineering has been the definite resource in the field of tissue engineering for more than a decade. The fifth edition provides an update on this rapidly progressing field, combining the prerequisites for a general understanding of tissue growth and development, the tools and theoretical information needed to design tissues and organs, as well as a presentation by the world's experts of what is currently known about each specific organ system. As in previous editions, this book creates a comprehensive work that strikes a balance among the diversity of subjects that are related to tissue engineering, including biology, chemistry, material science, and engineering, among others, while also emphasizing those research areas that are likely to be of clinical value in the future. This edition includes greatly expanded focus on stem cells, including induced pluripotent stem (iPS) cells, stem cell niches, and blood components from stem cells. This research has already produced applications in disease modeling, toxicity testing, drug development, and clinical therapies. This up-to-date coverage of stem cell biology and the application of tissue-engineering techniques for food production – is complemented by a series of new and updated chapters on recent clinical experience in applying tissue engineering, as well as a new section on the emerging technologies in the field. - Organized into twenty-three parts, covering the basics of tissue growth and development, approaches to tissue and organ design, and a summary of current knowledge by organ system - Introduces a new section and chapters on emerging technologies in the field - Full-color presentation throughout

NASA's Chandra X-Ray Observatory has ushered in a revolution in X-ray astronomy. Over the last two decades Chandra has captured stunning celestial X-ray images, measured spectra and monitored light curves to reveal and map the hottest, most energetic regions of the universe. Written by leading experts in each sub-field to celebrate its 20th anniversary, this book includes current reviews of the major discoveries and scientific results made by Chandra. Documenting the progress, discoveries and developments implemented by the mission, this book provides its readers with a comprehensive review of the mission thus far and its potential future implications. Including beautiful images of celestial sources generated from Chandra, and multi-wavelength data, as well as 3D figures and movies, interactive illustrations are also used throughout to enhance the text.

Advances in Virus Research, Volume 106, the latest in the series, contains new, informative updates on the topic. First published in 1953, this series covers a diverse range of in-depth reviews, providing a valuable overview of the current field of virology. - Contains contributions from leading authorities in the field of virology - Informs and updates on all the latest developments in the field

Selected peer-reviewed full text papers from XVI International Scientific and Practical Conference'New Polymer Composite Materials'Selected, peer-reviewed papers from the XVI International scientific and practical conference «New Polymer Composite Materials» (NPCM 2020), October 7-11, 2020, Nalchik, Russian Federation

Forensic Science is an interdisciplinary subject that uses principles and methodologies of various subjects including chemistry, biology, physics, geology, psychology, social science and engineering to help law enforcement agencies to enforce criminal laws and regulations to resolve civil and criminal cases. Body fluids, fingerprints, footprints, illicit drugs, explosives etc. are the evidences that can be found at the scene of crime in trace amount. These evidences are first analysed through screening and then confirmatory methods. During this process, the probability of sample loss is very high, especially when a sample amount is inadequate and therefore does not meet minimum requirement to analyse it. Generally, scientists discuss new-fangled nanotechnology research and its conversation turns to the commercial aspects or potential issues around health, safety, and the environment. In recent years, some of them have shown their interest to integrate nanotechnology with basic sciences and applied for forensic purposes, which are shifting the paradigm of forensic investigation process. Introduction of Forensic Nanotechnology as Future Armour is the first comprehensive book to consider both fundamental and applied aspects of forensic nanotechnology. This emerging field of forensic science investigates real-time crime scenes and terrorist activities, inquiries, detects the presence of explosive materials, biological indicators, document preservation, fingerprint enhancement and food adulteration using nanomaterial. Scientists and researchers are working on nanotechnology applications that may steer the power of forensic investigation, but the challenges to bring them from lab to the courtroom remain persistent. Moreover, some crucial concerns in forensic science such as analysis cost and time, methods'effectiveness and wide availability and results'accuracy and reliability are creating obstacles in forensic investigation and security. In this book we requested to enrich the scientific content as state-of-the-art in terms of application of nanotechnology in forensic science. In this way, all chapters will emphasise the emerging field of research to solve crime with the help of nanotechnology in various fields of forensic science like detecting explosives, biological indicators, document preservation, latent fingerprint and food adulteration. The integration of laboratory processes onto a nano platform is conceivably the most interesting advancement of nanotechnology highlighted in this book and some more issues like recent research developments, challenges and future opportunities are also addressed in this book. The book is written for a wide readership including researchers, undergraduate and graduate students from diverse backgrounds such as chemistry, materials science and nanotechnology engineering, physics, life sciences, forensic science, and biomedical engineering. It can be used not only as a textbook but also as a review and reference book. However, because many other nano technological applications for forensic analysis are yet to be studied, this book can be helpful to explore new opportunities. We hope that the chapters of this book will provide the reader with valuable insight as a revolutionary, protective tool in the fields of virtopsy, crime scene investigation, identification, forensic biology and toxicology. We also hope that after reading this book, researchers around the world will be motivated to enter into the field of forensic nanotechnology.

Biological Synthesis of Nanoparticles and Their Applications gives insight into the synthesis of nanoparticles utilizing the natural routes. It demonstrates various strategies for the synthesis of nanoparticles utilizing plants, microscopic organisms like bacteria, fungi, algae and so forth. It orchestrates interdisciplinary hypothesis, ideas, definitions, models and discoveries associated with complex cell of the prokaryotes and eukaryotes. Highlights: Discusses biological approach towards the nanoparticle synthesis Describes the role of nanotechnology in the field of medicine and its medical devices Covers application and usage of the chemicals at the molecular level to act as catalysts and binding products for both organic and inorganic Chemical Reactions Reviews application in physics such as solar cells, photovoltaics and other usage Microorganisms can aggregate and detoxify substantial metals because of different reductase enzymes, which can diminish metal salts to metal nanoparticles. The readers after going through this book will have detailed account of mechanism of bio-synthesis of nanoparticles.

This book provides an overview of the world market of therapeutic enzymes and enzyme inhibitors, rare diseases, orphan drugs, the costs of drug development and therapies, and enzymes in downstream processing of pharmaceuticals. It discusses carbonic anhydrase inhibitors and their multiple drug interactions, carboxylesterase inhibitors for pharmaceutical applications, employment of inhibitors for the treatment of neurodegenerative diseases, use of engineered proteins, bioactive peptides, and fibrinolytic enzymes for thrombolytic therapy, and enzymes important for the design and development of new drugs/drug metabolites such as aldehyde oxidases and cytochrome P450 enzymes and the role the latter play in vascular biology and pathophysiology. The treatment of cancer is explored in connection with enzymatic amino acid deprivation therapies and new drugs that act as chemical degraders of oncogenic proteins. The book also introduces the resistance mechanisms of cancer. Furthermore, it provides an insight into the relationship between pathological conditions of cardiovascular disease and oxidative stress. The text also focuses on the potential use of nanoparticles as carriers for enzymes with medical relevance, computer-aided drug design for the identification of multi-target directed ligands, and the development of improved therapeutics through a glycan-“designer” approach. It concludes with an introduction to the chemoenzymatic synthesis of drugs.

Metal Nanoparticles for Drug Delivery and Diagnostic Applications addresses the lifecycle of metal nanoparticles, from synthesis and characterization, to applications in drug delivery and targeting. It is an important resource for those in biomaterials, nanomedicine and pharmaceutical sciences, exploring gold, silver and iron-based drug delivery systems for controlled and targeted delivery of potential drugs and genes for enhanced clinical efficacy. Nanotechnology is widely used in drug delivery due to its ability to reduce plasma fluctuation of drugs, high solubility, and efficiency, the relatively low cost of nanoscale products, and enhancement of patient comfort, hence this resource is a welcome edition to the science. - Illustrates the progression of nanoparticle therapeutics from basic research to applications - Explores new opportunities and ideas for developing and improving technologies in nanomedicine and nanobiology - Discusses the toxicity of different types of metal nanoparticles and how to ensure their safe use

This book is the first to provide balanced examination of both pediatric liver disease and liver transplantation – two topics that are inherently related, given that most chronic liver disorders eventually require organ replacement. The different forms of liver disease encountered in the pediatric age group are first discussed in a series of disease-specific chapters that have a reader-friendly, uniform structure covering pathophysiology, diagnostic and treatment algorithms, clinical cases, and transition to adult care. Key topics in the field of liver transplantation are then addressed. Examples include indications and contraindications, surgical techniques and complications, immunosuppression, in pediatric liver transplantation, acute and chronic rejection and allograft dysfunction, and CMV and EBV infection in transplant recipients, long-term graft injury and tolerance. A section on pediatric hepatology across the world includes chapters presenting the features and management of pediatric liver disease in South-America, Africa and Asia. A closing section considers what the future holds for pediatric liver disease and its management, including novel genetic testing, cell therapy and gene therapy. Pediatric Hepatology and Liver Transplantation will be of value for a range of practitioners, from residents making their first approach to pediatric liver disease through to specialists working in transplantation centers.

Astrophysical research has led to the detection of thousands of planets outside the Solar System. About one-tenth of the extrasolar planets discovered so far reside in binary- or multi-stellar systems, and some of the closest known rocky exoplanets populate these multiple-star systems. While such environments seem good places to look for a second Earth, can Earth-like planets with two or more suns be habitable? And do solar system-like configurations have to be detected to find a habitable exo-Earth?This book addresses these questions. Starting with a brief overview of the various types of double star-planet configurations that have been observed so far, the book discusses the intriguing variety of planetary motion in such environments, taking into account the stellar type, evolution, and activity, and elaborates on how the presence of an additional stellar companion affects planet formation, system architectures and the habitability of planets in binary star systems. New methodologies developed in this area of research are explained and demonstrated for systems such as Alpha-Centauri, HD41004, Kepler-35, and many others. This monograph provides a grand entry to the exciting results that we expect from new missions like TESS, CHEOPS and Plato.

Nano-Biopesticides Today and Future Perspectives is the first single-volume resource to examine the practical development, implementation and implications of combining the environmentally aware use of biopesticides with the potential power of nanotechnology. While biopesticides have been utilized for years, researchers have only recently begun exploring delivery methods that utilize nanotechnology to increase efficacy while limiting the negative impacts traditionally seen through the use of pest control means. Written by a panel of global experts, the book provides a foundation on nano-biopesticide development paths, plant health and nutrition, formulation and means of delivery. Researchers in academic and commercial settings will value this foundational reference of insights within the biopesticide realm. - Provides comprehensive insights, including relevant information on environmental impact and safety, technology development, implementation, and intellectual property - Discusses the role of nanotechnology and its potential applications as a nanomaterial in crop protection for a cleaner and greener agriculture - Presents a strategic, comprehensive and forward-looking approach

About 7 million people worldwide are suffering from various inherited neuromuscular diseases. Gene therapy brings the hope of treating these diseases at their genetic roots. Muscle Gene Therapy is the only book dedicated to this topic. The first edition was published in 2010 when the field was just about to enter its prime time. The progress made since then has been unprecedented. The number of diseases that have been targeted by gene therapy has increased tremendously. The gene therapy toolbox is expanded greatly with many creative novel strategies (such as genome editing and therapy with disease-modifying genes). Most importantly, clinical benefits have begun to emerge in human patients. To reflect rapid advances in the field, we have compiled the second edition of Muscle Gene Therapy with contributions from experts that have conducted gene therapy studies either in animal models and/or in human patients. The new edition offers a much needed, up-to-date overview and perspective on the foundation and current status of neuromuscular disease gene therapy. It provides a framework to the development and regulatory approval of muscle gene therapy drugs in the upcoming years. This book is a must-have for anyone who is interested in neuromuscular disease gene therapy including those in the research arena (established investigators and trainees in the fields of clinical practice, veterinary medicine and basic biomedical sciences), funding and regulatory agencies, and patient community.

Nanoparticles in Pharmacotherapy explores the most recent findings on how nanoparticles are used in pharmacotherapy, starting with their synthesis, characterization and current or potential uses. This book is a valuable resource of recent scientific progress that includes the most cutting-edge applications of nanoparticles in pharmacotherapy. It is ideal for researchers, medical doctors and those in academia.