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The sixth edition of this internationally successful text includes the many positive advances in radiation oncology that have occurred over the past decade, and which continue to keep radiation at the cutting edge of cancer therapy. As previously, a multi-national authorship includes some of the top radiation oncologists, biologists, and physicists from North America and Europe, who highlight the core principles of radiobiology.

This new edition is a fully updated, comprehensive review of stereotactic radiosurgery (SRS) and stereotactic body radiation therapy (SBRT): its physics, clinical evidence, indications, and future directions. The utilization of stereotactic radiosurgery (SRS) and stereotactic body radiation therapy (SBRT) is increasing internationally because of several factors. First, it offers patients a local treatment option that has demonstrated effectiveness similar to traditional surgery without the morbidity of general anesthesia and open surgical resection. Second, recent advancements in the quality of scientific evidence supporting a SRS or SBRT-containing approach in patients continues to evolve and demonstrate favorable disease-specific outcomes with little, if any, toxicity in various anatomic disease sites and for various conditions including cancer, benign tumors, and other psychiatric and neurologic conditions. Third, and most provocatively, is the notion that definitive local therapy (i.e. SRS or SBRT) in patients with cancer can boost the immune system to fight cancer in other sites throughout the body. While traditional medical knowledge would suggest that all patients with metastatic cancer are incurable, there is a mounting body of evidence that there is a subset of these patients that can be cured with definitive SRS or SBRT. This volume thus delves into each of these benefits and aspects of treatment, guiding physicians to the best treatment plan for their patients. Expert, international authors provide guidelines for SRS and SBRT use by clinicians. Chapters are divided into six main sections: Radiobiology of Radiosurgery and Stereotactic Body Radiation Therapy, Intracranial Radiosurgery Technique, Intracranial Radiosurgery by Indication, Stereotactic Body Radiation Therapy Technique, Stereotactic Body Radiation Therapy by Indication, The Future of Radiosurgery and SBRT. Overall physics are explained, as well as specific considerations for particular surgical tools (including the Leksell Gamma Knife and Accuray CyberKnife), techniques (including fractionated and charged particle radiosurgery), and anatomic sites (including brain metastases, pituitary tumors, and the prostate). Since the first edition published, the field has grown significantly. There is now significant new data to support preoperative radiosurgery, increased indications in metastatic cancers, as well as integration with new drug therapies and imaging techniques. Each chapter is thus fully updated with the latest in medical advancements and new scientific research. Detailed images and charts enhance the chapters. This book provides physicians with a single, practical resource incorporating both of these broad categories of treatment, SRS and SBRT, and better defines the current role and the direction of radiosurgery.

Nesta quarta edição de Condutas em Neurologia Infantil, a colaboração entre duas importantes instituições, Unicamp e UnB, permitiu a atualização de grande parte dos tópicos das edições anteriores. Esta nova edição reforça a importância da semiologia como base, aprofunda diversos temas e inclui conteúdos inéditos, especialmente nas áreas de neurogenética e transtornos do neurodesenvolvimento, refletindo de forma mais precisa a prática clínica atual da especialidade. Organizado em tópicos e com uma abordagem prática, o principal objetivo deste livro é apoiar a conduta clínica diária em Neurologia Infantil, tanto em ambientes hospitalares (pronto-socorro, enfermaria, UTIs) quanto em contextos ambulatoriais. Sem a pretensão de esgotar os temas abordados, sua finalidade é oferecer orientações iniciais e guiar o manejo de casos neurológicos na faixa etária infantojuvenil. Trata-se de um livro de consulta pensado para integrar o dia a dia dos profissionais, como uma ponte entre o que a teoria ensina e o que a prática revela e exige. Destinado principalmente a neurologistas infantis, pediatras, neurologistas e neurocirurgiões, também é de interesse para estudantes de graduação e pós-graduação em Medicina, bem como para profissionais de outras áreas da saúde, que buscam uma fonte de aprendizado nesse campo científico tão vasto quanto desafiador.

This book provides an insightful reference to a range of relevant orthopaedic and neurological surgical techniques for the spine. It features detailed insight into how to approach treating patients exhibiting a wide range of symptoms of a particular disorder, from anatomy to biomechanics and pathology. Detailed explanations of the validity of a chosen treatment methodology are provided as are multiple choice questions to enable the reader to systematically develop a deep understanding of the content covered. MCQs in Spine Surgery details a range of the latest knowledge in spinal surgery and techniques, making it a valuable resource for all medical professionals who treat these patients. The inclusion of multiple choice questions make the work of particular use to those preparing for board examinations too.

The book delves into the multifaceted world of migraine pain, offering a profound understanding of its underlying pathophysiology and presenting established treatment strategies for its effective management. It discusses the intricate world of migraine pain, offering valuable insights into its diverse aspects. Starting with an exploration of migraine's epidemiology and etiology and the complex factors contributing to this debilitating headache disorder. This book explores the significance of lifestyle changes and offers practical strategies for incorporation. Furthermore, the impact of diet and nutrients on migraine management is extensively covered, shedding light on their role in alleviating symptoms. This book serves as a comprehensive guide, blending scientific insights with practical approaches, making it an indispensable resource for healthcare professionals, researchers, and individuals seeking a deeper understanding of migraine pain. By addressing both established practices and cutting-edge advancements, it bridges the gap between knowledge and effective management, offering a holistic perspective on this challenging condition.

Neuropathic Pain, Volume 179 of the latest release in the International Review of Neurobiology serial,, highlights new advances in the field, with this new volume presenting interesting chapters. Each chapter is written by an international board of authors. - Provides the authority and expertise of leading contributors from an international board of authors - Presents the latest release in International Review on Neurobiology serials - Updated release includes the latest information on Neuropathic Pain

Comprehensive Hematology and Stem Cell Research is the first major reference to cover both stem cell research and therapy as well as the range of hematological disorders they are currently used to treat and may potentially be able to treat in the future. This five volume set includes fundamentals, such as the underlying mechanisms of the blood and immune system, highlighting blood disorders and cancers of the blood, including lymphoma, leukemia, and myeloma. Other sections cover stem cell research and therapy, from harvesting stem cells to their utilization in cancer treatments. Finally, the work looks to the future and explores newer stem cell research that may lead to future treatments. This book is an excellent resource for students at the graduate and post-graduate levels, academics, and researchers in the fields hematology, immunology and oncology. - Compiles foundational knowledge and breakthrough research into one concise, comprehensive reference - Takes a translational, bench-to-bedside approach to hematological disorders and stem cell therapies - Covers clinical applications of stem cells, advances in the field, and promising new research

Dizziness and Vertigo describes the basic knowledge and practical skills necessary for managing patients presenting with common symptoms of dizziness and vertigo. It provides practitioners with a comprehensive overview of these conditions, steps for diagnosing patients and various treatment options.This revised and updated edition provides a framework for the accurate diagnosis and management of patients with dizziness and vertigo, covering clinical assessments and case studies. It also includes new methods for treating Ménière's disease and benign paroxysmal positional vertigo (BPPV) and in the field of vestibular rehabilitation.Dizziness and Vertigo is an essential reference for all those who manage patients in the outpatient setting, including general practice trainees, ear/nose/throat (ENT) specialists and physiotherapists.

This is an open access title available under the terms of a CC BY-NC-ND 4.0 International licence. It is free to read at Oxford Academic and offered as a free PDF download from OUP and selected open access locations. Jasper's Basic Mechanisms of the Epilepsies has served as the definitive reference in the field of basic research in the epilepsies for five decades through four well-regarded editions. Since its inception, the book has been an indispensable must-read and belongs in the hands of every experimental epilepsy investigator, practicing epileptologist, clinical neuroscientist, and student for both clinical and basic science reference, doctoral and board exam preparation. This fifth edition is the most ambitious yet and remains the definitive reference in the field, providing encyclopedic and updated coverage of the current understanding of basic research in the epilepsies, while also mapping new research directions for the next decade, and reviewing how molecular laboratory evidence is now being translated into new therapeutics. In 79 chapters, the book considers the role of interactions between neurons, synapses, and glia in the initiation, spread, and arrest of seizures. It examines mechanisms of excitability, synchronization, seizure susceptibility and, ultimately, their contributions to epileptogenesis. It provides a framework for expanding the monogenic epilepsy genome and understanding the complex heredity responsible for common epilepsies. It explores the molecular and cellular disease mechanisms of ion channelopathies, developmental epilepsy genes, and progressive myoclonic epilepsies. It considers newly emerging mechanisms of epilepsy comorbidities. And, for the first time, it describes current efforts to identify biomarkers of disease progression and translate discoveries of epilepsy disease mechanisms into new therapeutic strategies at the frontier of molecular medicine.

Transcranial stimulation encompasses noninvasive methods that transmit physical fields-such as magnetic, electric, ultrasound, and light-to the brain to modulate its function. The most widespread approach, transcranial magnetic stimulation (TMS), has emerged as an important tool in several areas of neuroscience as well as in clinical applications in psychiatry and neurology. Originally envisioned as a way to measure the responsiveness and conduction speed of neurons and synapses in the brain and spinal cord, TMS has also become an important tool for changing the activity of brain neurons and the functions they subserve as well as an causal adjunct to brain imaging and mapping techniques. Along with transcranial electrical stimulation techniques, TMS has diffused far beyond the borders of clinical neurophysiology and into cognitive, perceptual, behavioural, and therapeutic investigation and attracted a highly diverse group of users and would-be users. Another major success of TMS has been as a treatment in psychiatry, where it is now in routine use worldwide. The field of noninvasive neuromodulation has matured and diversified considerably in the past decade, with an expansion in the number of tools available and our understanding of their mechanisms of action. This second edition of The Oxford Handbook of Transcranial Stimulation brings together the latest developments and important advances in all areas of Transcranial stimulation. The new volume captures the rapid progress made since the first edition, and provides an authoritative and comprehensive review of the state of the art. It also highlights challenges, opportunities, and future directions for this rapidly changing field. The book focuses on the scientific and technical background required to understand transcranial stimulation techniques and a wide-ranging survey of their burgeoning applications in neurophysiology, neuroscience, and therapy. Each of its six sections deals with a major area and is edited by an international authority therein. It will serve researchers, clinicians, students, and others as the definitive text in this area for years to come.

This encyclopedic reference takes into account the status of interventional neuroradiology in the treatment of acute ischemic stroke. It explains and discusses the various options to recanalize occluded extra-and intracranial vessels. The book provides an in-depth description of the different endovascular treatment strategies, including thrombectomy for large vessel inclusion, balloon angioplasty and intracranial atherosclerotic stenosis, and stenting of extra- and intracranial arterial dissections and their conservative treatment, and bypass surgery for subacute and chronic cerebral hypoperfusion. The book also offers tips and tricks for each procedure to enable readers to understand better the benefits and limitations of the endovascular management of ischemic stroke patients. Similarly, it explains the technical aspects of the procedures with their respective pros and cons. Written by respected experts in the field, the book will be a valuable resource for interventional neuroradiologists and neurologists, vascular and endovascular neurosurgeons, stroke neurologists, and other practitioners at all levels of experience.

This new edition summarizes the data and techniques for hypofractionation and stereotactic radiation in a clinically-accessible way. Hypofractionated radiation therapy, which consists of larger-dose radiation treatments that are given over a shorter time period compared to conventional radiation fraction sizes, is used to treat a variety of cancers, including prostate, breast, lung, and colorectal. Conventional radiation therapy and hypofractionated radiation therapy often have different effectiveness rates for cancer treatment and have different impacts on normal tissues in terms of causing toxicity. There is a significant and continually evolving body of literature on the use of different dosing regimens to treat a variety of cancers, and radiation oncologists need to keep up with the various dosing schedules, the effect of each regimen on cancer control in different cancers, and how the different schedules affect each organ in terms of toxicity. This book provides concise, up-to-date information ranging from commonly-used dose-fractionation schemes for hypofractionated and stereotactic body radiotherapy to simulation and treatment specifications to published safety and efficacy data. Chapters additionally examine the biological rationales for the efficacy of hypofractionated radiation; present clinical studies that demonstrate the efficacy and safety of hypofractionated radiation treatment in a variety of cancers; and describe the advances in technology that have allowed hypofractionated radiation to be safely given. All chapters are fully revised with the latest treatments and updated effectiveness and toxicity of previously discussed treatments, all based on recent clinical trials and large analytical studies. This is an ideal guide for radiation oncology clinicians and trainees.

VETERINARY ANESTHESIA AND ANALGESIA A thoroughly updated new edition of the foundational reference on veterinary anesthesia and analgesia Veterinary Anesthesia and Analgesia: The Sixth Edition of Lumb and Jones is a fully updated revision to this comprehensive, authoritative reference to all aspects of veterinary anesthesia and pain management. Encompassing both scientific principles and clinical applications, the new edition adds new knowledge, techniques, and discussion of emerging issues throughout. Fourteen new chapters significantly expand the coverage of patient monitoring modalities and nociception and pain, while presenting new information on safety culture, infection prevention and control, biomedical engineering, and point-of-care ultrasound. Logically organized into sections, information on basic principles, pharmacology, specific body systems, and specific species is easy to access. Comparative anesthetic considerations for dogs and cats, horses, ruminants, swine, laboratory animals, free-ranging terrestrial mammals, marine mammals, reptiles, amphibians, fish, and birds are discussed. Chapters are devoted to anesthesia and pain management of common domestic species and patient populations, including updated chapters on local and regional anesthetic and analgesic techniques. A companion website offers video clips of point-of-care ultrasound techniques and pain assessment and scoring. Readers of Veterinary Anesthesia and Analgesia: The Sixth Edition of Lumb and Jones will also find: Significantly expanded coverage of patient monitoring, including new chapters devoted to anesthetic depth and electroencephalography, electrocardiography, blood pressure, ventilation, oxygenation, and anesthetic gas monitoring. More in-depth coverage of respiratory physiology and pathophysiology, with new sections covering oxygen therapy, mechanical ventilation, anesthetic management considerations for bronchoscopy, intrathoracic procedures, including one-lung ventilation, and patients with respiratory disease. Expanded coverage of pain physiology and pathophysiology, recognition and quantification of pain, and clinical pain management, including both pharmacologic and nonpharmacologic modalities. A companion website incorporating video clips and example pain scoring sheets to complement the more than 500 images in the text itself. With its unparalleled multidisciplinary approach, Veterinary Anesthesia and Analgesia is a must-own volume for veterinary anesthesia specialists and researchers; specialists in other disciplines, including both small and large animal surgeons; practitioners; and students.

The year 2022 was supposed the best year of my career. Being in my early 50s I was about to complete my first decade working in the pharmaceutical industry. I would be lying if I said that the transition from the energy industry to pharmaceuticals had been easy, but after a few difficult years I felt confident about the future. Then one day, I was rushed to hospital because I had collapsed in the garden. A scan showed that I had a brain tumour. From that day onwards matters changed dramatically – things that were important to me before lost all their value whilst other things that I had taken for granted before became suddenly very important to me. This book is my attempt to make a difference to all people who are suffering from a terminal illness, or indeed all people who must make personal decisions at difficult and emotionally charged times. This book is intended for individuals who wish to improve their decision-making skills by using structured and analytical thinking. In this personal book, I am using examples and thought experiments to illustrate how decision analysis can be used to increase our awareness of available choices and uncertainties that we are exposed to.

La cefalea es la primera causa de consulta médica; sin embargo, en ocasiones es minimizada porque no se encuentran lesiones estructurales, muchas veces fáciles de abordar pero muchas más con una gran dificultad para concluir el diagnóstico que es clínico y proporcionar el tratamiento más apropiado, el cual cuando es efectivo le devuelve al paciente la calidad de vida perdida por la presencia de dolor agudo o crónico. Para un mejor acompañamiento, el libro está organizado en secciones, que incluyen los grandes tipos de cefaleas: las primarias y las secundarias, y sus tipos, además de las cefaleas que se presentan en casos especiales, como la cefalea tensional y la cefalea hípnica, entre otras.

The “Lung Cancer Diagnosis and Treatment: An Interdisciplinary Approach” is the ninth volume of the “Interdisciplinary Cancer Research” series, publishes comprehensive reviews on the diagnosis and treatment of lung cancer. Application of artificial intelligence in lung cancer detection is explained well. Recent advances in the treatment of lung cancer is presented in this volume, while opportunities and challenges in immunotherapy are discussed. This interdisciplinary series is of special value to researchers working on oncology. This is the main concept of Cancer Immunology Project (CIP), which is a part of Universal Scientific Education and Research Network (USERN). This interdisciplinary book will be of special value to researchers, oncologists, and oncosurgeons who wish to extend their knowledge on lung cancer.

Cognitive neuroscience is the interdisciplinary study of how cognitive and intellectual functions are processed and represented within the brain, which is critical to building understanding of core psychological and behavioural processes such as learning, memory, behaviour, perception, and consciousness. Understanding these processes not only offers relevant fundamental insights into brain-behavioural relations, but may also lead to actionable knowledge that can be applied in the clinical treatment of patients with various brain-related disabilities. This Handbook focusses on the foundational principles, methods, and underlying systems in cognitive and systems neuroscience, as well as examining cutting-edge methodological advances and innovations. Containing 34 original, state of the art contributions from leading experts in the field, this Handbook is essential reading for researchers and students of cognitive psychology, as well as scholars across the fields of neuroscientific, behavioural and health sciences. Part 1: Background Considerations Part 2: Neuroscientific Substrates and Principles Part 3: Neuroanatomical Brain Systems Part 4: Neural Dynamics and Processes Part 5: Sensory-Perceptual Systems and Cognition Part 6: Methodological Advances

Con il catalogo I libretti italiani a stampa dalle origini al 1800, pubblicata dal 1990 al 1994 da Bertola & Locatelli a Cuneo, Claudio Sartori ha donato alla ricerca sulla storia dell'opera e dell'oratorio una base completamente nuova. Rispondendo alle richieste degli studiosi di rendere nuovamente disponibile questo opus magnum, Don Juan Archiv Wien e Hollitzer Verlag pubblicano una ristampa e un'edizione e-book, con un ritratto dell'autore e della sua opera realizzato da Federica Riva. With his catalogue I libretti italiani a stampa dalle origini al 1800, published by Bertola & Locatelli in Cuneo between 1990 and 1994, Claudio Sartori laid a completely new foundation for the research of the history of operas and oratorios. Responding to the requests of scholars to make this opus magnum available again Don Juan Archiv Wien and Hollitzer Verlag publish a reprint and an e-book edition, including a portrait of the author and his work by Federica Riva.

Con il catalogo I libretti italiani a stampa dalle origini al 1800, pubblicata dal 1990 al 1994 da Bertola & Locatelli a Cuneo, Claudio Sartori ha donato alla ricerca sulla storia dell'opera e dell'oratorio una base completamente nuova. Rispondendo alle richieste degli studiosi di rendere nuovamente disponibile questo opus magnum, Don Juan Archiv Wien e Hollitzer Verlag pubblicano una ristampa e un'edizione e-book, con un ritratto dell'autore e della sua opera realizzato da Federica Riva. With his catalogue I libretti italiani a stampa dalle origini al 1800, published by Bertola & Locatelli in Cuneo between 1990 and 1994, Claudio Sartori laid a completely new foundation for the research of the history of operas and oratorios. Responding to the requests of scholars to make this opus magnum available again Don Juan Archiv Wien and Hollitzer Verlag publish a reprint and an e-book edition, including a portrait of the author and his work by Federica Riva.

In this rapidly changing health care environment, a challenge today's physical therapist faces is finding, evaluating, and implementing current best evidence into practicce, an integral part of health care professional educational programs. With that goal in mind, Physical Therapy Management of Patients With Spinal Pain: An Evidence-Based Approach provides a comprehensive research-based overview of the examination and physical therapy interventions of the spine. Inside Physical Therapy Management of Patients With Spinal Pain, Drs. Deborah M. Stetts and J. Gray Carpenter evaluate the current evidence related to spinal pain and present it in a format that allows for an easy transition to the clinical environment. By providing effective clinical interventions, rather than relying on habits or tradition, patients benefit from an increased likelihood of improved quality of life with the least potential of personal and financial risk.Some features include:• Over 650 photographs, images, and tables• Access to a supplemental video Website with new book purchase• Best practice for evaluating and treating the lumbar spine, thoracic spine, and cervical spine• Comprehensive coverage of the clinical presentation of spine-related pathologies from evaluation to treatmentEach chapter outlines the history, physical examination, physical therapy diagnosis, evidence-based management guidelines, and case studies for each topic. Case studies will challenge the reader's clinical reasoning skills with the use of current best evidence throughout the initial examination and subsequent treatment sessions.Bonus!Also included with Physical Therapy Management of Patients With Spinal Pain is access to a supplemental Website containing more than 375 video demonstrations corresponding to the tests and measures, examination, evaluation, and intervention procedures covered within the text.Physical Therapy Management of Patients With Spinal Pain: An Evidence-Based Approach is the go-to reference text and accompanying Web site for the physical therapy students, or clinicians who are reaching for best practice through providing the highest level of evidence-informed care in the evaluation and management of patients with spinal pain.

The Routledge International Handbook of Clinical Hypnosis explores and clarifies the challenge of defining what hypnosis is and how best to integrate it into treatment.It contains state-of-the-art neuroscience, cutting-edge practice, and future-oriented visions of clinical hypnosis integrated into all aspects of health and clinical care. Chapters gather current research, theories, and applications in order to view clinical hypnosis through the lens of neurobiological plasticity and reveal the central role of hypnosis in health care. This handbook catalogs the utility of clinical hypnosis as a biopsychosocial intervention amid a broad range of treatment modalities and contexts. It features contributions from esteemed international contributors, covering topics such as self-hypnosis, key theories of hypnosis, hypnosis and trauma, hypnosis and chronic pain management, attachment, and more.This handbook is essential for researchers, clinicians, and newcomers to clinical hypnosis, in medical schools, hospitals, and other healthcare settings.Chapters 4, 35, 62 and 63 of this book are freely available as a downloadable Open Access PDF at http://www.taylorfrancis.com under a Creative Commons Attribution-Non Commercial-No Derivatives (CC-BY-NC-ND) 4.0 license.

Migraine Management: Current Pharmacological and Non-pharmacological Options is a comprehensive guide to established, recent, and ongoing pharmaceuticals and device development projects. The book provides detailed information on the historical developments of migraine pain management, druggable targets, drugs action mechanisms, drugs for acute treatment and preventive care of patients, administration routes, and alternative treatments. This is the ideal reference for academic researchers interested in anti-migraine pharmacology. It will also be a perfect reference for physicians and care professionals involved in the well-being of migraine patients. - Offers a comprehensive overview of pharmacological and alternative migraine pain treatment options - Covers the historical developments and current targets for drug development and delivery routes - Provides insights into comorbidities and their impact in patient compliance to treatment

This book is focused on a clinical-based diagnostic approach of autonomic dysfunctions, highlighting main diagnostic tools and pharmacological and non-pharmacological therapies available nowadays. The autonomic nervous system (ANS) is a subcomponent of the peripheral nervous system (PNS) and dysfunction of one or more subdivisions of the ANS, when accompanying other diseases, is linked to a worse prognosis of the latter. In some circumstances or when severe, dysfunction of ANS itself results in symptoms and disability. A myriad of factors can cause autonomic dysfunction and more than one can concur even in the same patient; due to the expansive nature of the ANS, patients can be affected by a wide range of conditions. Each chapter is characterized by a similar structure and is devoted to a different dysfunction. For each pathology, the book offers the essential information on mechanisms of action, treatments and outcomes. Written by experts in the research of these disorders, the volume addresses primarily Neurologists, but will be a useful tool also for Gastroenterologists, Ophthalmologists, Urologists, Cardiologists and Internal medicine specialists.

This Handbook serves as an authoritative reference book in the field of Neuroengineering. Neuroengineering is a very exciting field that is rapidly getting established as core subject matter for research and education. The Neuroengineering field has also produced an impressive array of industry products and clinical applications. It also serves as a reference book for graduate students, research scholars and teachers. Selected sections or a compendium of chapters may be used as “reference book” for a one or two semester graduate course in Biomedical Engineering. Some academicians will construct a “textbook” out of selected sections or chapters. The Handbook is also meant as a state-of-the-art volume for researchers. Due to its comprehensive coverage, researchers in one field covered by a certain section of the Handbook would find other sections valuable sources of cross-reference for information and fertilization of interdisciplinary ideas. Industry researchers as well as clinicians using neurotechnologies will find the Handbook a single source for foundation and state-of-the-art applications in the field of Neuroengineering. Regulatory agencies, entrepreneurs, investors and legal experts can use the Handbook as a reference for their professional work as well.​

Migraine Biology, Diagnosis, and Co-Morbidities, Volume 195 covers a wide range of issues related to migraine. The epidemiology, global and personal impacts of migraine are covered, including topics on the pathophysiology of migraine and migraine aura, the pathophysiology of the associated symptoms of photophobia and phonophobia, and the genetics of migraine. The classification and diagnostic criteria of common and uncommon subtypes of migraine are also explored in detail, including childhood variants. Issues related to the diagnosis and management of vestibular migraine and the co-morbid disorder of persistent postural-perceptual dizziness are also covered. The important comorbidities of migraine such as anxiety, depression and other forms of chronic pain will also be discussed, along with the current state and future directions of migraine research and management. - Summarizes research and clinical information on the pathophysiology of migraines - Explores the pathophysiology of aura, photophobia, and phonophobia - Discusses migraine triggers - Reviews migraine subtypes and comorbid conditions in migraine - Explores the relationship of migraine to chronic pain and cerebrovascular and psychological conditions - Concludes with future directions in migraine research and treatment

This book provides a physician's pathfinder for COVID specific headache disorders as well as general headache practice in a pandemic era. Practical solutions to headache management at every level are highlighted, along with the changing nature of previous headache disorders under lockdown conditions. Headache Disorders in Pandemic Conditions examines the specific nature of headache symptoms during COVID-19 infection, the secondary causes of COVID-specific headache disorders and practical issues of previous known headache disorders during a pandemic. The book also explores the effect of lockdown on headache management and changes in headache education, practice, risks and guidelines. Neurologists, headache specialists, general practitioners, medical students and residents will find this book to be a practical and clear guide to Covid-19 specific headache disorders in clinical practice.

This monograph, now in its 2nd edition with 31 new chapters and significant updates, is the first book of its kind written specifically for graduate students and clinicians. The monograph is based on the 4-volume treatise, Handbook of the Cerebellum and Cerebellar Disorders (Springer, 2013; 2nd edition: 2022), the definitive reference for scientists and neurologists in the field of cerebellar neurobiology and related areas. There have been fundamental advances in the basic science and clinical neurology of the cerebellum and its role in sensorimotor function and cognition. Essentials of the Cerebellum and Cerebellar Disorders makes this large and expanding body of knowledge readily accessible to trainees and clinicians alike. It is organized into easy to read and short chapters that are ideal for students and clinicians. The most common cerebellar disorders encountered in the clinic are covered. The editors are world leaders in the field, and the chapters are authored by an international panel of experts drawn from cerebellar laboratories and ataxia clinics throughout North America, Europe and Asia. Essentials provides a solid grounding in the field of cerebellar research and ataxiology from cerebellar cellular biology and circuity to clinical practice, and it serves as a springboard to a deeper appreciation of both the principles and the complexities of cerebellar neurobiology. Clinicians are expected to have a deep appreciation of cerebellar disorders, not only in specialized ataxia clinics but also in adult and pediatric neurology, neurosurgery, psychiatry and neuropsychology practices, and in outpatient and inpatient rehabilitation settings. This book is an indispensable resource for students and practitioners navigating the evolving field of cerebellar motor and cognitive neurology. It also links to the more expansive Handbook for those who need to explore the topics in this monograph in greater depth.

Informed by the Biopsychosocial Model, this Encyclopedia of Child and Adolescent Health examines multiple aspects of child and adolescent development and physical and mental health. According to the Biopsychosocial Model, health is determined by the reciprocal interactions between biological (e.g., genetics, physical development, family health history), psychological (e.g., mental health, identity developmental, attitudes), and social (e.g., family, peers, school, social supports) factors. This theory posits that each one of these factors alone is not sufficient to understand health; instead, it is important to understand how these interactive components ultimately influence health outcomes. In addition to the Biopsychosocial Model, this Encyclopedia of Child and Adolescent Health has a translational approach. Each section and all applicable entries include a discussion of prevention or intervention efforts that can inform health and health promotion, and prevent health risks. - Presents a comprehensive review of current child and adolescent research, along with critical insights into the future direction of the field, including translation and prevention - Includes concise, authoritative chapters that are expertly authored make this an easy-to-read, reliable reference resource - Provides a clear thematic structure that allows for easy exploration across the discipline's different sub-fields. - Helps readers find their topics of interest, all of which are contextualized and linked to relevant literature

This is the third, completely updated edition of a comprehensive book in which many of the world's leading lung cancer specialists discuss the recent advances in the radiation oncology of lung cancer and reflect on the latest research findings in lung cancer and other intrathoracic malignancies. Lung cancer remains the major cancer killer in both sexes worldwide. It is so despite significant progress in recent decades in both diagnostic and treatment approaches. New biological and technological advances in this field are now faster incorporated in the overall decision-making process and are bringing fast and substantial improvements in both survivals and quality of life of lung cancer patients. Optimized patient-oriented approaches are reality of the third decade of this millennium and thoracic oncologists strive towards nothing but seamlessly delivering it in a continuous battle with lung cancer. The first three sections of the work cover the basic science of lung cancer, clinical investigations, including histology and staging, and a wide range of fundamental treatment considerations. Current treatment strategies for small cell and non-small cell lung cancer as well as other intrathoracic malignancies are then explained and evaluated in detail, with due attention to novel approaches that promise further improvements in outcome. The various types of treatment-related toxicity are discussed, and quality of life studies and prognostic factors are also considered. After evaluating the latest technological and biological advances, including stereotactic radiotherapy, and particle therapy, the book concludes by thorough consideration of specific aspects of clinical research in lung cancer. This concise yet comprehensive book is an invaluable resource for radiation oncologists.

All over the world, educational institutions confronted emergency policy changes caused by the COVID-19 pandemic. Due to this, academic activities were provided mostly by remote teaching and learning solutions. The transition to emergency remote teaching and learning raised some challenges regarding technical, pedagogical, and organizational issues. It is important for higher education institutions to prepare themselves to deal with future emergency scenarios, promoting an in-depth reflection about the future challenges in the post-pandemic era. Developing Curriculum for Emergency Remote Learning Environments supports creating and promoting an education-as-a-business strategy for higher education institutions by sharing possible business models. It provides a collection of different approaches to online education in the perspective of the future of education environments. Covering topics such as distance learning experiences, online practice improvement, and remote testing, this premier reference source is an excellent resource for educators and administrators of higher education, pre-service educators, IT professionals, librarians, researchers, and academicians.

This new edition is the first to be released since orofacial pain was recognized as the 12th dental specialty by the American Dental Association. Although the structure resembles previous editions, significant changes have been made. The most recent International Classification of Diseases, Eleventh Edition (ICD-11) classification system is used throughout, featuring new diagnostic codes and tables mapping differences between ICD-10 and ICD-11. Other revisions are inclusion of cervical spinal disorders and associated headaches as well as extracranial and systemic causes of orofacial pain, greater emphasis on headache pathophysiology and updates to management including new pharmacologic agents, and sections on “newer trends” related to electronic cigarettes/vaping and the SARS-CoV-2 global pandemic. Out with the old, in with the new. This text delivers the evidence-based assessment, diagnosis, and management of orofacial pain conditions to keep you up to date about this emerging and expanding field.

This book addresses a wide range of issues situated in the core of theoreticians'and clinicians'work in the field of giftedness. It gathers practical issues, relevant for the lives of many gifted children, adolescents and adults, from a neuropsychological point of view. By studying the basic questions in gifted education through a neuropsychological lens, this book aims to establish a uniform new way for the treatment of gifted children with social or emotional difficulties, learning disabilities, physical limitations, or psychological and psychiatric disorders. This book helps educators and mental-health professionals to obtain a deeper understanding of the neurological system and its role in learning. This includes memory, knowledge-processing, making connections, and the implications on the cognitive, emotional, and physical aspects – all of which play major roles in the life of each gifted child and adolescent. By acquiring this new knowledge, more teachers, counsellors, psychologists and psychiatrists will be able to help individuals materialize their giftedness, while preserving their mental health and productivity.

Dystonia, Volume 169, the latest release in the International Review of Neurobiology serial, highlights new advances in the field with this new volume presenting interesting chapters on topics including Clinical Features and the Science of Classification, What Can Epidemiological Studies Tell us About the Neurobiology of Dystonia, Dystonia Genes and Their Biological Pathways, Functional Anatomy of Dystonia, Physiology of Dystonia: Human Studies, Physiology of Dystonia: Animal Studies, Experimental Pharmacology: Targeting Neurotransmitters, Experimental Pharmacology: Targeting Metabolic Pathways, Adult-Onset Focal Dystonias: One Biology or Many?, Early-Onset Inherited vs Late-Onset Idiopathic Dystonias: Same or Different Biological Mechanisms?, and much more. - Provides the authority and expertise of leading contributors from an international board of authors - Presents the latest release in International Review on Neurobiology serials - Updated release includes the latest information on Dystonia

This book summarizes recent and critical aspects of advanced materials for environmental protection and remediation. It explores the various development aspects related to environmental remediation, including design and development of novel and highly efficient materials, aimed at environmental sustainability. Synthesis of advanced materials with desirable physicochemical properties and applications is covered as well. Distributed across 13 chapters, the major topics covered include sensing and elimination of contaminants and hazardous materials via advanced materials along with hydrogen energy, biofuels, and CO2 capture technology. Discusses the development in design of synthesis process and materials with sustainable approach. Covers removal of biotic and abiotic wastes from the aqueous systems. Includes hydrogen energy and biofuels under green energy production. Explores removal of environmental (soil and air) contaminants with nanomaterials. Reviews advanced materials for environmental remediation in both liquid and gas phases.

This book, now in an extensively revised second edition, provides information on the basic science and tissue interactions of dental lasers and documents the principal current clinical uses of lasers in every dental discipline. The applications of lasers in restorative dentistry, endodontics, dental implantology, pediatric dentistry, periodontal therapy, and soft tissue surgery are clearly described and illustrated. Information is also provided on laser-assisted multi-tissue management, covering procedures such as crown lengthening, gingival troughing, gingival recontouring, and depigmentation. The closing chapters look forward to the future of lasers in dentistry and the scope for their widespread use in everyday clinical practice. When used in addition to or instead of conventional instrumentation, lasers offer many unique patient benefits. Furthermore, research studies continue to reveal further potential clinical applications, and new laser wavelengths are being explored, developed, and delivered with highly specific power configurations to optimize laser–tissue interaction. This book will bring the reader up to date with the latest advances and will appeal to all with an interest in the application of lasers to the oral soft and/or hard tissues.

This book offers a comprehensive analysis of microalgal cultivation methods and optimization of astaxanthin production for various applications, including clinical uses, algae polymers, proteins and pigments, food applications and packaging, algae forming, cosmetics, and more. Microalgae are unicellular living forms and are the primary producers that play a major role in the ecosystem. Commercially, while many documents are available, some recent fields are yet to be explored. The book comprises 19 chapters contributed by experts and reviews the recent developments in the cultivation, harvest, and genetic engineering of H. pluvialis-derived astaxanthin. It also discusses their bottlenecks and challenges in commercial-scale production, as well as current and prospective global market. Current research supports the exploration of new topics and practical applications of microalgae and their products, which will also benefit academia. The book will be an importantresource for researchers and industry, providing comprehensive knowledge on broad topics. Flow charts, updated methods, and colour images are included to help the readers'understanding.

The Diabetes Textbook: Clinical Principles, Patient Management and Public Health Issues (2nd Edition) addresses diabetes from a comprehensive, multidisciplinary perspective. Its purpose is to integrate state-of-the-art information on diabetes from specialists in various disciplines, including epidemiology, public health, pathophysiology, non-pharmacologic and pharmacologic treatment, patient support, acute and chronic complications, new and unproven therapies, and prevention. The main benefit of “The Diabetes Textbook” is its integrative approach. The book is therefore intended for three main types of readers: 1) physicians and health professionals seeking a comprehensive approach to diabetes; 2) those with previous expertise in a specific professional area who want to expand their knowledge; and 3) those interested in learning about topics not previously covered, who will find the contents of “The Diabetes Textbook” both enriching and innovative. The Diabetes Textbook is intended for a broad readership, including professors of medicine and related disciplines (nursing, nutrition, psychology); general physicians; internists and specialists, e.g. in ophthalmology, endocrinology, cardiology, obstetrics and gynecology, pediatrics, geriatrics, epidemiology and public health. To address these readers'needs, the second edition is divided into the following eleven sections: 1) Magnitude of the Problem from an Individual and Social Context, 2) Diagnosis, Classification and Mechanisms of Disease, 3) Global Experiences in Diabetes Care, 4) Basic Components of Management: Patient-Centeredness, Evidence-Based Medicine, and Outcomes, 5) Resources of Support for Persons with Diabetes, 6) Drug Therapy, 7) Cardiovascular Risk Factors, 8) Acute Complications, 9) Chronic Complications, 10) Diabetes in Special Populations, and 11) Novel Therapeutic Approaches: Evidence-Based and Non-Proven, and Diabetes Prevention.

This comprehensive review of research and best practice clinical management of spinal cord, neurodegenerative, and cerebral disorders is intended for both researchers and clinicians. Encompassing hereditary and acquired disorders from disease and accident, the book explores motor control disorders associated with stroke, dementia, seizure, encephalitis, and more. Covering disorders of both children and adults, the book discusses the latest advances in treatments related to neuroplasticity, neural tissue transplantation, and immunotherapy. - Summarizes assessment, disease course, and best practice treatment - Includes hereditary disorders and disorders from disease or accident - Discusses advances in neuroplasticity, tissue transplantation, immunotherapy, and other treatments - Reviews effects of dementia, stroke, seizure, encephalitis, cancer, and more

This book provides a comprehensive introduction to the current state-of-the-art in skin cancer, exploring the recent developments, appraising the current evidence and providing future directions with particular emphasis on interdisciplinary collaboration and need for clinical trials. It covers all aspects of skin cancers, including epidemiology, pathology, surgical and non-surgical treatments. It will be a valuable reference for oncologists, dermatologists, dermatopathologists, surgeons, allied health care professionals and other specialists and trainees with a special interest in skin cancer who want to update their knowledge in the multidisciplinary management of such patients. The book will be of interest to medical physicists and radiographers who would like an overview of the current practice in skin cancer. The book can be used by students in medicine, nursing, radiography and medical physics. Features Provides a comprehensive review of all aspects of skin cancer management. Edited by experts in the area, with interdisciplinary and international collaborators. Promotes a'Bigger picture'approach to the topic with multidisciplinary insight.

Bodily awareness is one of the most interesting and enigmatic forms of experience. Our earliest and most pervasive form of conscious experience, it also arguably remains the most private. Bodily awareness has also long played a central role in the study of the mind and self-consciousness, and is fundamental to much current philosophical and psychological research.The Routledge Handbook of Bodily Awareness is an outstanding reference source to this fascinating subject. Comprising over thirty chapters by an international team of contributors, the Handbook is divided into seven parts: Epistemology and Metaphysics Historical Issues Body Representation Sensing the Body Dynamics Pathology Interaction Within these sections specific topics covered include bodily ownership, personal identity, self-consciousness, body modelling in robot design, body illusions, touch, proprioception, phantom limb syndrome, pain, eating disorders, out-of-body experiences and virtual reality. The handbook features specially commissioned contributions from researchers in a wide array of disciplines, whilst being accessible to readers with any disciplinary background. It also includes an interdisciplinary introduction, written by the editors, tying together the central themes with particular attention to the interaction between conceptual, technological and empirical issues.The Routledge Handbook of Bodily Awareness will be of great interest to those in a wide variety of philosophical subdisciplines as well as those in psychology, cognitive science, sociology and related subjects.

Das Prostatakarzinom ist die häufigste Krebserkrankung des Mannes; allein in Deutschland gibt es etwa 70.000 Neuerkrankungen pro Jahr. Bei der krebsspezifischen Mortalität steht das Prostatakarzinom an dritter Stelle. Ein Viertel aller neu diagnostizierten PCA befinden sich bereits in fortgeschrittenem Stadium. Hierzu zählen neben den lokal fortgeschrittenen (cT3/4) auch die primär metastasierten (cN1 bzw. cM1) Tumorstadien. In der Vergangenheit bedeutete eine Metastasierung bei einem bekannten Prostatakarzinom eine nicht kurative Situation. Diese Sichtweise hat sich in den letzten Jahren geändert, da sowohl eine lokale Therapie, wie radikale Prostatektomie oder Bestrahlung in kurativer Dosierung des primären Prostatakarzinoms, ein verbessertes Outcome mit verbessertem Überleben der Patienten bedeutet. Das metastasierte Prostatakarzinom ist auch für erfahrene Behandler anspruchsvoll. In diesem Buch werden die aktuellen Standards zu Risikostratifizierung und Staging sowie den sich derzeit bietenden Therapieoptionen zusammengefasst.Das aktuelle Fachbuch zum Thema für alle Urologen, Onkologen, Strahlentherapeuten, Nuklearmediziner und Internisten.

Virtual Reality (VR) is a rapidly maturing technology that offers new and unique solutions to otherwise intractable problems in the study of cognition, behavior and neuroscience. VR removes many of the constraints imposed by laboratory paradigms, allowing us to track cognitive, behavioral and brain responses to naturalistic (or even impossible) situations without sacrificing experimental control. But VR is not a tool that can be swiftly and effortlessly integrated into existing research pipelines; currently, the benefits of VR are accompanied by a host of methodological challenges and important practical considerations. To help navigate this new methodology, this volume provides a balanced review of both the exciting new findings emerging from VR labs and the challenges and limitations that are part and parcel of VR research. This volume is an important first step toward establishing a standardised methodology for conducting research in VR. To this end, thevolume provides a wealth of practical advice for researchers who are new to the technology. This volume is authored by an interdisciplinary team of VR researchers including computer scientists, engineers, psychologists and neuroscientists. It highlights current research in the field to demonstrate how VR advances our understanding of the mind, while also providing groundbreaking solutions in applied domains.

Adverse Childhood Experiences and Their Life-Long Impact explores how these experiences influence cognitive, behavioral and social experiences in adulthood. The book conceptualizes the types of violence, abuse, neglect, and/or trauma that factor into ACEs. It also explores the psychopathological outcomes of ACEs among children, including neurodevelopmental and psychosocial mechanisms. By drawing on cross-cultural perspectives, the authors provide insight into the variations between the adversity and trauma children experience. Sections also cover preventive measures, risk factors and various forms of interventional treatment, making this book a core read for psychologists, physicians, social workers, educators and researchers in the field. - Provides a comprehensive framework for understanding adverse childhood experiences - Reviews the link between ACE and homelessness, substance abuse, and physical and/or sexual violence in adulthood - Highlights key components of cross-cultural perceptions on child abuse and neglect, including differences of gender - Explores options for prevention and intervention for those who experience adverse childhood experiences

Cognitive Archaeology, Body Cognition, and the Evolution of Visuospatial Perception offers a multidisciplinary and comprehensive perspective on the evolution of the visuospatial ability in the human genus. It presents current topics in cognitive sciences and prehistoric archaeology, to provide a bridge between evolutionary anthropology and neurobiology. This book explores how body perception and spatial sensing may have evolved in humans, as to enhance a'prosthetic capacity able to integrate the brain, body, and technological elements into a single functional system. It includes chapters on touch and haptics, peripersonal space, parietal lobe evolution, somatosensory integration, neuroarchaeology, visual behavior, attention, and psychometrics. Cognitive Archaeology, Body Cognition, and the Evolution of Visuospatial Perception represents an essential resource for evolutionary biologists, anthropologists, archaeologists, and neuroscientists who are interested in the role of body perception and spatial ability in human cognition. - Addresses the role of body perception and sensing in human evolution - Supplies a comprehensive overview on the cognitive mechanisms associated with the integration between brain, body and tools - Offers a bridge between evolutionary anthropology, archaeology, and cognitive sciences

La tecnologia fa ormai parte della quotidianità delle famiglie e, con l'avvento del Covid-19, l'universo digitale si è espanso ulteriormente e con rapidità. La particolarità di questo testo è di leggere il fenomeno a partire dagli effetti che ha sul corpo, considerando tanto le risorse quanto le criticità che si accompagnano all'utilizzo di web e tecnologie: cyberbullismo, fruizione senza limiti, contenuti non adatti all'età sono, infatti, solo alcuni dei rischi che possono incontrare i soggetti in via di sviluppo, apripista rispetto alle novità, ai cambiamenti digitali e alle prese con device, immagini, relazioni e realtà sempre in evoluzione.

This book on non-migraine primary headaches in medicine is the second machine-generated scientific book in medicine published by Springer and reflects a new publication format which focuses on literature reviews: state-of-the-art computer algorithms were applied to select relevant sources from Springer Nature journal, rearrange them in a topical order, and provide short summaries of these articles. The result is the auto-summarization of current texts, organized by means of a similarity-based clustering routine in coherent chapters and sections. The human intervention of a world-renowned expert in this field grants the scientific soundness and appropriate organization of the contents identified. The AI-based approach seemed especially suitable to provide an innovative perspective as the topics are indeed both complex, interdisciplinary, and multidisciplinary, as is tension-type headache, the most diffuse among the chronic non communicable diseases. The result of this innovative process will of help especially for readers with limited time, interested in migraine and wishing to learn more about the subject quickly and if they are new to the topic. Springer seeks to support anyone who needs a fast and effective start in their content discovery journey, from the undergraduate student exploring interdisciplinary content, to Master- or PhD-thesis developing research questions, to the practitioner seeking support materials, this book can serve as an inspiration, to name a few examples.

Pediatric headache is the most common neurological complaint that presents to the general pediatrician, urgent care and emergency rooms, and to pediatric neurology. Despite how common headaches are in the pediatric population and how many children continue to suffer from their headaches on a daily basis, there remains a tremendous disconnect for those tasked with being the first-line providers (general pediatric providers). This stems from the fact that headache patients can be so variable and challenging, with numerous comorbid concerns, all the while requiring an individualized treatment approach without a cure.The purpose of this proposed book is to help foster a better understanding of how to approach, assess, and ultimately treat pediatric headache for the general pediatric provider in an attempt to make what once was a daunting, overwhelming complaint from patients and their families into something each general pediatric provider can conquer with confidence. With the aid of experts in the field of pediatric headache, this book will begin by providing the foundation as to what types of headaches, primary and secondary as well as their precursors, are commonly seen in the pediatric population. From there, the focus will turn to when should the provider worry about a patient who presents with headaches. The clinic visit -- from the history to the “red flags” to the pertinent exam -- will be reviewed in depth to help distinguish between primary and secondary headaches as well as who warrants an evaluation. Additionally, comorbid concerns will be covered as these may have direct impact on the evaluation and subsequent treatments offered. The next section will delve into the treatment of pediatric headache with a comprehensive approach covering everything from lifestyle to complementary and alternative therapies/treatments, to medications, both acute and prophylactic. Other morespecialized treatment options such as procedures and devices will also be discussed albeit these options are more likely to be offered by a specialist rather than a general provider. A subsequent section will highlight the unique challenges for the older adolescent patients as they transition into young adulthood. The closing section will highlight the future of pediatric headache.

Primary health care providers such as pediatricians and family medicine physicians commonly encounter children with neurologic symptoms such as headache, double vision, facial weakness etc. Most books currently available in the specialty of pediatric neurology are “condition” or “disorder” based, and most of them are geared towards pediatric neurologists, not generalists who take care of children. A common thread amongst most currently available books in Pediatric Neurology is that the practitioner already knows what “condition” or “disorder” the child is suffering from. This book focuses on symptoms to a large extent. However, children with chronic neurological conditions will follow up with their primary care physicians after their visit with the sub-specialists. They may have questions or ongoing concerns regarding the diagnosis that has been made or being considered. This book attempts to provide information to the primary care physician regarding management and follow upof such children as well. This book serves as a guide for busy clinicians who take care of children presenting with neurological symptoms- with special emphasis on symptoms that are commonly encountered in clinical practice. For each symptom, a brief introduction is given as well as a definition and epidemiologic information for the given symptom. Readers are also instructed on what historical features and physical examinations are essential in narrowing the differential diagnosis. A recommendation on the management of the condition is then established. Instructions on when one should refer the patient to subspecialists for further evaluation and management are clearly laid out. Finally, a list of appropriate resources is provided for families, as well as clinical pearls that can be quickly scanned when one is pressed for time. The overarching goal of this book is to enable the primary care physician to make a confident diagnosis, triage efficiently and initiate treatment if need be.Written by experts in the field, Symptom-Based Approach to Pediatric Neurology is a valuable resource for evaluation and management of children presenting with neurologic symptoms for primary care providers who take care of children.

This book includes nine chapters that describe recent advances in health and disease. Chapter One discusses controversies regarding the use of intraoperative cell salvage during surgery involving bacterial contamination or malignancy. Chapter Two presents an overview of clinical applications of all-trans retinoic acid. Chapter Three explores the role of angiotensin-converting enzyme 2 receptors in COVID-19 infection. Chapter Four describes potentially beneficial sports supplements for endurance athletes. Chapter Five studies the influence of low-impact aerobic physical activity on Berger's disease. Chapter Six evaluates the effects and toxicity features of paclitaxel nanoformulations. Chapter Seven examines a potential link between methamphetamine abuse and glycogen synthase kinase-3. Chapter Eight investigates the health-promoting potential of tryptophan-derived betalin. Finally, Chapter Nine deals with the role of glucagon in exploring the corticotrop pituitary reserve.

The popular occupational therapy textbook Physical Agent Modalities: Theory and Application for the Occupational Therapist has been newly updated and revised into a comprehensive Third Edition. Using current occupational therapy terminology and philosophy, this text establishes the theoretical basis and clinical reasoning for the use of physical agent modalities in practice. The biophysiological effects of the modalities are identified and discussed alongside their impact on function and performance. Relevant to both students and practitioners, the Third Edition educates on the proper, safe, and judicious use of physical agent modalities while treating clients.Written by Dr. Alfred G. Bracciano, this book outlines the application procedures for each modality, indications for their use, and the precautions and contraindications of the modality.New to the Third Edition: Organizational boxed asides and tables related to each concept area Evidence-based research boxes and tables related to clinical reasoning case studies New chapters on physiological impact of interventions, soft tissue techniques, and health care reform Global perspective providing a resource for the international therapist New color flow charts and improved graphics Each chapter contains: Learning objectives Key terms Case studies Included with the text are online supplemental materials for faculty use in the classroom.With up-to-date information and new chapters, Physical Agent Modalities: Theory and Application for the Occupational Therapist, Third Edition provides a user-friendly, organized reference ready to be applied in the clinical setting.