Search

Volume 24, entitled Targeted Metallo-Drugs: Design, Development, and Modes of Action, of the series Metal Ions in Life Sciences (MILS), fosters inter-disciplinary research in the vibrant field of Biological Inorganic Chemistry. Inspired by the clinical success of cisplatin as a leading anticancer drug but mindful of the shortcomings associated with its use including dose-limiting toxic side effects and acquired or intrinsic drug resistance, scientists across the globe have been endeavoring to identify new metallo-drugs for therapeutic exploitation. This has led to innovative metallo-drug candidates that (i) enhance cancer cell selectivity, thus reducing toxic side effects, and/or (ii) possess new modes of action to improve efficacy and also target resistance pathways. This and more are captured in MILS- 24 which consists of 12 comprehensive, well-illustrated, and up to date chapters with over 1600 citations, 100 figures, and 10 tables with key contributions from 32 international experts from Europe, Asia, and North and South America. MILS- 24 not only keeps the scientific community abreast of latest developments, it also serves as an invaluable resource to stimulate further research on targeted metallo-drug design and development. It covers anticancer, antimicrobial, antiviral, and other agents, such as those targeting tropical diseases and cyanide poisoning and radiometals in molecular imaging and therapy It highlights recent metallo-drug developments targeting COVID-19 It features advanced spectroscopic methods and metallomics as important tools to elucidate the modes of actions of metallo-drugs

Sistemas de Informação na era digital são elementos essenciais presentes em todas as atividades das empresas. A transformação digital apresenta muitos desafios e oportunidades para gestores e desenvolvedores que exigem conhecimentos e informações específicas relacionadas à implantação de tecnologia da informação. Este livro se propõe a apresentar diversos temas relacionados ao uso de sistemas de informação nesta era digital, de forma simples e objetiva, explorando temas como: transformação digital, aplicações corporativas, redes sociais, questões sociais, legais e éticas na era digital, bancos de dados e informações gerenciais, governança de dados, internet das coisas e aplicações mobile, governança de TI, gestão de projetos, gestão de serviços e gestão da segurança. Dessa forma, organizações e gestores poderão se beneficiar desse potencial tecnológico para inovar e reinventar os seus modelos de negócio para enfrentar os desafios que esses tempos requerem. Colaboradores: Adriano José da Silva Neves Ana Carolina Riekstin André Montoia Barata Carlos Rodrigo Cordeiro Alves Durval Lucas dos Santos Junior Edimara Mezzomo Luciano Edmir Parada Vasques Prado Fabio Henrique Souza Prando Guilherme Costa Wiedenhöft Ilana de Almeida Souza Concilio Luciano Vieira de Araújo Mônica Mancini Regina da Silva de Camargo Barros Rodrigo Hiroshi Ruiz Suzuki Sonia Rosa Arbues Decoster

The optimal management of children who receive dialysis therapy requires a thorough understanding of the multidisciplinary nature of their treatment. The multiple organ systems that are often impacted by acute and chronic impairment of kidney function makes the care of this patient population highly complex. This 3rd edition of Pediatric Dialysis provides authoritative and comprehensive information on all aspects of dialysis-related care for children to assist the clinician in achieving the best possible patient outcomes. Like the two preceding editions, the 3rd edition enlists experts from North America, South America, Europe, and Asia to provide their perspectives on virtually all issues pertaining to dialysis-related management for children, based on years of clinical and research experience. The book contains sections on all essential topics including when to initiate dialysis, peritoneal dialysis, hemodialysis, managing secondary complications, nutritional therapy, drugs and dialysis, dialysis outcomes, and transition to adult care. Each chapter has been thoroughly updated in terms of content and references. The book also includes several new chapters on topics such as remote patient monitoring, acute kidney injury management in the developing world, and antibiotic stewardship in the dialysis unit, maintaining the text's preeminent status as a worldwide source for pediatric dialysis care.

Le premier cas de SIDA a été observé aux USA en 1981 et le virus VIH-1 isolé à l'Institut Pasteur de Paris en 1983. Il est rapidement apparu que le VIH-1 était pandémique et que l'épicentre était situé en Afrique centrale ; le passage d'un virus du chimpanzé à l'Homme au début du XXe siècle a constitué l'événement princeps de cette pandémie. Le VIH-1 présente une grande variabilité génomique et il a effectué une formidable diversification après son passage chez l'Homme, aboutissant ainsi à la définition de groupes, de sous-types et de formes recombinantes circulantes (CRFs pour « circulating recombinant forms »). La répartition de ces virus est différente d'un continent à l'autre. Pour résumer la situation, on peut dire qu'il existe plus de 50 VIH-1 différents et que ceci explique les très grandes difficultés de mise au point d'un vaccin. L'auteur de ce livre, François-Charles Javaugue, a eu le mérite, le courage et la ténacité de réaliser une cartographie mondiale des différents VIH-1 en retraçant l'histoire de leur mise en évidence, le tout à partir de plusieurs milliers de références bibliographiques issues de revues scientifiques spécialisées. Il s'agit d'un travail unique en langue Française qui, à un moment donné, c'est-à-dire fin 2010 début 2011 et début 2012, présente l'ensemble des données publiées et est une référence, sinon la référence, dans le domaine.