Search

Recent advances in the industrial application and industrial development of seaweeds are important in addressing the world's growing needs for healthy nutrients. Seaweeds are a potentially sustainable feedstock for future food and feed, green chemicals, and fuels. For seaweed biorefinery, the fractionation of the biomass to co-produce multiple products is crucial in the efficient valorization of the aquatic biomass. Widespread use of seaweed is still limited by a number of factors including harvesting access, seasonality and geographical location of algae, toxicological aspects, as well as the availability of scalable production methods. A good example is protein isolation from algae, since current processes of algal protein isolation are time-consuming and economically unviable. Seaweeds and Seaweed-Derived Compounds offers a comprehensive overview of sustainable seaweeds for the recovery of low-cost dietary nutrients from algae and alga-based biomass and their validation to meet market the requirements of consumers and industry in different sectors. With chapters focusing on seaweeds as foods, pharmaceuticals and cosmetic and dermatological applications, this text provides multidisciplinary knowledge of this sustainable biomass presented with a mix of academic and industrial perspectives.

A situação jurídica das pessoas com doenças raras diz sobre todos nós. Não se cuida aqui, portanto, apenas de alguns poucos doentes sem relevância numérica. Um leitor apressado poderia pensar que a presente obra não trata do direito médico e da saúde atinente a todos. Gabriel Massote Pereira – Mestre em Direito Médico - nos oferece um estudo aprofundado sobre os temas da saúde, que atingem a todos os que se socorrem da Justiça. Atualmente, hospitais e tribunais se tornaram locais de súplica por mais saúde. Todos queremos viver mais e melhor. Para tanto, cresce a cada dia a necessidade de bem compreender como obter em juízo as mais modernas terapias. O livro que temos em mãos reúne a experiência prática de um grande tribuno dos foros médico-judiciais nacionais, com o aprofundamento científico que a academia universitária lhe proporcionou. Gabriel advoga e defende arduamente os temas da saúde nos tribunais há várias décadas, e nunca se furtou de compartilhar seu vasto conhecimento em cursos, palestras e seminários. Sua visão crítica da jurisprudência vai certamente ajudar muitos dos que precisam ampliar os horizontes de compreensão do direito médico. Advogados, magistrados, promotores de justiça, defensores públicos e gestores em saúde em geral vão encontrar neste texto vários pontos de atenção para as decisões que precisam tomar. São inúmeros acórdãos, leis, normativas administrativas e atos das agências reguladoras da saúde que foram aqui filtrados, tendo como foco central o tema das doenças raras e dos medicamentos órfãos. Os que possuem uma doença rara já enfrentam sozinhos o calvário médico de sua situação. Nem sempre contam com o melhor entendimento das operadoras de saúde e dos agentes governamentais sobre sua condição pessoal. O que Gabriel não deseja é que as barras dos tribunais acabem sendo para eles um peso adicional. Tive a honra de acompanhar as várias etapas desta pesquisa, que é viva e seguirá se aprofundando. Sinto-me assim inteiramente à vontade para recomendar a leitura deste notável estudo, que agora vem a público para enfrentar o diálogo com todos os especialistas do setor. Georghio Tomelin Doutor em Direito pela USP. Doutor em Filosofia pela PUCSP. Coordenador do Mestrado em Direito Médico da Unisa. Professor do Doutorado da ITE-Bauru.

This book provides perspectives on the combinatorial approach of plant-based compounds for drug discovery to achieve better disease-curing outcomes introducing the evolution of ethnobotany and traditional medicine in modern drug development. It covers the biotechnological interventions for the identification and screening of compounds and their optimization to enhance affinity, selectivity, bioavailability, and metabolic stability. While overviewing how essential compounds are successfully identified from herbal/ medicinal plants and utilized in the form of effective drugs which eventually have helped in combating long-term diseases in humans, the book also provides a better understanding of how infection and the diseases caused are regulated at the molecular and physiological stages. The book also highlights the importance of bioactive compounds in modern drug discovery and the perspectives for a potential industrial application. The chapters are developed by eminent subject experts with due care and clarity and cover an up-to-date literature review with relevant illustrations. The book would cater to the needs of undergraduate and graduate students, researchers, and scientists, and may attract the attention of pharmaceutical companies/industrialists and health policymakers.

This book describes transcription factors in the context of hematopoietic development and reveal mechanistic insights how they orchestrate specific gene expression patterns. Several examples from lymphoid and myeloid lineages are given as well as particular examples of leukemia fusion proteins that contain a part of a transcription factor. In the given chapters covering each one particular example, the function of transcription factors is characterized in normal as well as leukemic contexts. New technologies such as ChIP-Seq or RNA-Seq, that make use of genome-wide sequencing, have shown that such master regulators of blood cell development often work in combinatorial fashion and, when dysregulated, results in leukemogenesis. This book is not only intended for experts but it should also be a useful resource for younger scientists or scientists from other disciplines, who may use this book as a stimulating starting point for further discoveries and/ or translational endeavors.

To be updated with second edition.This is a book about the science behind whisky: its production, its measurement, and its flavor. The main purpose of this book is to review the current state of whisky science in the open literature. The focus is principally on chemistry, which describes molecular structures and their interactions, and chemical engineering which is concerned with realizing chemical processes on an industrial scale. Biochemistry, the branch of chemistry concerned with living things, helps to understand the role of grains, yeast, bacteria, and oak. Thermodynamics, common to chemistry and chemical engineering, describes the energetics of transformation and the state that substances assume when in equilibrium. This book contains a taste of flavor chemistry and of sensory science, which connect the chemistry of a food or beverage to the flavor and pleasure experienced by a consumer. There is also a dusting of history, a social science.

This book covers the basic knowledge of biojet fuel, explores the current technological status, and presents future prospects for commercial biojet fuel production. The focus of this book is on biojet fuel production from different types of potential substrates. It also includes technoeconomic analysis and life cycle assessment of biojet fuel. Biojet fuel is currently recognized as the best alternative to petroleum-based jet fuel due to its renewability and sustainable features. However, there is a scarcity of reports on biojet fuel production from various types of substrates.The aviation industry globally consumes approximately 200 million tonnes of jet fuels each year, with a projected continuous growth rate of 5% per year until 2050 (Seymour et al., 2020). Currently, the global demand for jet fuel is predominantly met by petroleum-based fuels. However, the limited availability of fossil fuels and increasing concerns about climate change have placed significant pressure on commercial airlines to reduce greenhouse gas emissions and embrace cleaner and more sustainable practices.Biojet fuel has emerged as the most favorable alternative to petroleum-based jet fuel due to its renewable nature and sustainable characteristics. Despite its potential, there is a limited number of reports available on the production of biojet fuel from different types of substrates. The present scenario of biojet fuel necessitates the development of improved and cost-effective technologies that can yield long-term benefits.The book is useful for students and researchers in various branches of life sciences, including environmental biotechnology, bioprocess engineering, renewable energy, chemical engineering, nanotechnology, biotechnology, microbiology, and more.

This volume illuminates exciting new developments and approaches of classical mechanical problems. The ongoing necessity for research in this field stems from the need for new engineering solutions that save our resources and supplies sustainability standards as well as further considerations such as recyclability and environmental compatibility. These demands stimulate the special design of materials, e.g. composites. The interaction between materials and structures is related to different length scales and the combination of micro-, meso- or macroscale approaches results in new application possibilities. In addition, materials and structures are increasingly being analyzed under the influence of various physical fields.

Rabies is one of the oldest known pathogens, is incurable, and has the highest fatality rate of all infectious diseases. The Americas is the only region with bat rabies virus, including vampire bat rabies. The region is rich in cultural references and notable for many discoveries in the field, including the current vaccine potency test, diagnostic assay, conception of oral vaccines for wildlife, the first human survivor and the first successful canine rabies program executed at a broad level. Rabies remains the most important viral zoonosis, with tens of thousands of human fatalities and tens of millions of exposures annually, which can be used to model for other pathogens, such as COVID-19. There is an international effort to eliminate human rabies caused by dogs over the next decade, and the Americas represent the primary region with the greatest proof-of-concept evidence to accomplish this goal. This two-volume set addresses the medical history and modern results of rabies in countries throughout the Americas, including the implications of and on cultural, economic, sociological, and research developments in the region. Volume II provides an in-depth analysis of the rabies'presence and impact in specific countries, including historical perspectives, advances in research and understanding, and current status.

This book provides a comprehensive overview of recent advances in nanotechnology as an alternative strategy for addressing antimicrobial resistance (AMR). Examining nanotechnology-based methods such as nanoencapsulation, drug delivery, and conjugation, the text highlights their successful application in treating microbial infections with reduced resistance and off-target toxicity. The introductory section outlines AMR and explores diverse mechanisms of microbial resistance, emphasizing the potential of nanotechnology to surmount these challenges. Subsequent chapters investigate the role of specific nanomaterials—metal nanoparticles, metal oxide nanoparticles, functionalized quantum dots, magnetic nanoparticles, bimetallic nanoparticles, nanocomposites, carbon nanomaterials, and polymer-based nanomaterials—in overcoming antimicrobial resistance. Several chapters focus on the efficacy of nanoemulsions as an antimicrobial delivery method, underscoring their inherent antimicrobial properties, capacity to enhance drug solubility, stability, bioavailability, and targeting potential at the organ and cellular levels. The concluding section provides a detailed review of liposomes, dendrimers-based nanoparticles, and micelles as drug delivery vehicles in the context of combating pathogens resistant to antimicrobials.

This book presents the diversity of Dinosaur tracks found in Mesozoic basins in Brazil and brings it in a paleoenvironmental context. Each chapter includes information about the geology of the site, the distribution of the footprints, their diversity as well as a paleontological interpretation. The book provides information about the paleoenvironmental and paleoclimatic aspects of the Mesozoic. All chapters contain a geological map, images of the footprints and dinosaur tracks and a reconstruction of the environment in which the tracks were found. The book is aimed at geoscientists and paleontologists, including researchers which focus on evolution subjects.

This book offers an insightful exploration into the relationship between diet and Multiple Sclerosis (MS), aiming to address a crucial question: Can dietary interventions serve as effective preventative and therapeutic measures for patients with MS? Delving into this question, the book examines various nutritional components and regimens, shedding light on their potential impacts on the progression, relapse rate, and development of MS. It offers readers valuable insights into how dietary choices can influence the management of this condition. Backed up by evidence gathered from review and clinical trial papers, the book discusses the role of vitamins such as A, B, and D, as well as dietary supplements like caffeine, carnitine, and lipoic acid in benefiting patients with MS. Particular attention is given to the significance of vitamin D in lowering the risk of developing MS and its immunomodulatory effects on the inflammatory processes associated with the disease. In parallel, the book also addresses the detrimental effects of diets such as the Western or high salt diet (HSD) on MS prognosis, emphasizing how these dietary regimens can harm the gut microbiome and exacerbate inflammatory responses, ultimately promoting demyelination of the central nervous system (CNS). The book then explores alternative dietary approaches that confer a protective effect on the gut microbiome and the CNS, including whole grain, fasting, Mediterranean, and ketogenic diets. This comprehensive resource is an essential reading for patients with MS seeking to understand the potential impacts of diet on their overall health, as well as healthcare professionals and researchers interested in exploring dietary interventions for MS management.

Industrial crops offer farmers new market opportunities to increase their revenue by producing high-value products, focusing on fiber, forest, and energy crops, industrial oilseeds, rubber and resins, pharmaceuticals, and more. Technological innovations in agriculture have facilitated higher yields, but conserving crop genetic resources and diversity remains crucial for sustainable agricultural production. This poses a challenge that can be addressed through modern tools of biotechnology and genomics, utilizing the wealth of sequenced plant genomes. This book addresses the need for knowledge in managing the risks and conservation of genetic diversity associated with advanced technology. It provides comprehensive coverage of plant genomics and biotechnology, catering to post-graduate students, researchers, employees of seed and biotechnology companies, as well as instructors in plant genetics, breeding, and biotechnology fields.

This book deals with analytical techniques and methods applied in several sectors of technology and industry and serves as a concise and up-to-date reference for the practical application of analytical chemistry. Divided into 10 chapters, the book starts with an introduction to the fundamentals of analytical chemistry, followed by a review of modern analytical technologies and their application in different industrial sectors and activities such as agrochemicals and pharmaceuticals, ores and mining, polymers, biotechnology, and oil & gas. Particular attention is given to industrial environmental issues, where the author discusses the advanced analytical techniques used to provide quantitative information about pollutants in aqueous and gaseous effluents and their carbon footprint. The book finishes with a chapter summarizing the main remarks and conclusions on advanced analytical techniques used in different industrial sectors, as well as on topics of sustainability, and instrumental analysis. In this book, readers will find valuable insights, including real-life examples, of how classical and instrumental techniques can be used by industry, to help professionals in the quality control of raw materials, products and processes, in the assessment of the formulation contamination, environmental pollution and in the evaluation of sustainability, among others. Given its breadth, the book appeals to professionals (mainly chemists, biochemists, and engineers), researchers, professors, and graduate students.

Recent discoveries in microbiology are hard to grasp for those unfamiliar with scientific jargon, and the research data can be overwhelming even for those working in other scientific fields. This book aims to remedy this situation by presenting the most interesting findings and current trends in microbiology in an easy-to-read and understandable format. The first part tells the story of the beginnings of microbiology itself and introduces the reader to the founders of this fascinating research discipline. The second part focuses on communication between microorganisms and how they organize themselves into fascinating microbial cities called “biofilms”. The reader also learns how bacteria exchange genetic material - mechanisms that are the root of the emergence of multidrug-resistant superbugs, pathogens that pose a major burden to human health and our healthcare systems. The third part is devoted to the latest techniques being used by scientists to study, control, and manipulate microorganisms for our benefit. The final part links the first three parts together and highlights how infectious diseases, including coronaviruses, can be transmitted from animals to humans, how global warming is affecting emerging diseases, and provides information on the actions that need to be taken to get ahead of pathogenic microbes and future pandemics. This comprehensive, state-of-the-art book is intended for anyone interested in microbiology and epidemiology, from biology and biomedical students in schools and colleges, to patients suffering from infectious diseases who want to learn more about their condition. The concepts covered in this book contribute to UN Sustainable Development Goal 3: Health and Well-Being.

••Selected for Doody's Core Titles® 2024 in Clinical Genetics•• Human Reproductive and Prenatal Genetics, Second Edition provides application-driven coverage of key topics in human reproductive and prenatal genetics, including genetic control underlying the development of the reproductive tracts and gametogenesis, the genetics of fertilization and implantation, the genetic basis of female and male infertility, as well as genetic and epigenetic aspects of assisted reproduction. Also examined are the genetics and epigenetics of the placenta in normal and abnormal pregnancy, preimplantation genetic diagnosis and screening, and cutting-edge advances in noninvasive prenatal screening, prenatal genetic counseling, and bioethical and medicolegal aspects of relevance in the lab and clinic. This new edition has been fully revised to address new and evolving technologies in human reproductive genetics, with new chapters added on chromatin landscapes and sex determination, genetic alterations of placental development and preeclampsia, metabolism and inflammation in PCOS, pre-implantational genetic testing, maternal genetic disorders, bioethics, and future applications. - Features chapter contributions from leading international scientists and clinicians - Provides in-depth coverage of key topics in human reproductive and prenatal genetics, including genetic controls, fertilization, placental development, embryo implantation, in vitro culture of the human embryo for the study of post-implantation development, and more - Identifies how researchers and clinicians can implement the latest genetic, epigenetic, and –omics-based approaches - Includes all new chapters on evolving technologies and recent genetic discoveries of relevance to reproductive medicine

This volume comprises the select peer-reviewed proceedings of the International Conference on Advances and Applications of Artificial Intelligence and Machine Learning 2022 (ICAAAIML 2022). It aims to provide a comprehensive and broad-spectrum picture of state-of-the-art research and development in the areas of artificial intelligence, machine learning, deep learning, and their advanced applications in computer vision and blockchain. It also covers research in core concepts of computers, intelligent system design and deployment, real-time systems, WSN, sensors and sensor nodes, software engineering, image processing, and cloud computing. This volume will provide a valuable resource for those in academia and industry.

Modulation of Oxidative Stress: Biochemical, Physiological and Pharmacological Aspects explores the field using an interdisciplinary approach, including chemical, biological, physiological, pharmaceutical, pharmacological and physicochemical perspectives. The book is comprised of three main parts, with the first discussing the biochemical aspects of oxidative stress modulation. Other sections cover physiological and pathophysiological aspects on relevant conditions, including aging, neurological diseases, cerebral cavernous malformation, maternal and early-life malnutrition, Alzheimer's disease, liver transplant, and cancer. Final content is dedicated to pharmacological aspects and includes chapters on phytotherapy and flavonoids. This book is a strong reference for pharma researchers in academia and industry considering leveraging modulation of oxidative stress as a strategy for the development of new drugs. Biochemists and Nutritionists may also benefit of the foundational understanding of cellular redox processes laid out. - Provides the latest updates in the fast-developing field of REDOX biochemistry and pharmacology - Presents content that is clear and easy to read - Useful for researchers and instructors in many fields

Plant Polysaccharides as Pharmaceutical Excipients explores innovative techniques and applications of plant-derived polysaccharides as pharmaceutical excipients. Plant polysaccharides are sustainable, renewable and abundantly available, offering attractive properties in terms of water solubility, swelling ability, non-toxicity and biodegradability. These qualities have resulted in extensive exploration into their applications as excipients in a variety of pharmaceutical dosage forms. This book takes a comprehensive, application-oriented approach, drawing on the very latest research that includes sources, classification and extraction methods of plant polysaccharides. Subsequent chapters focus on plant polysaccharides for individual pharmaceutical applications, enabling the reader to understand their preparation for specific targeted uses. Throughout the book, information is supported by illustrations, chemical structures, flow charts and data tables, providing a clear understanding. Finally, future perspectives and challenges are reviewed and discussed. - Explains sources, classifications, extraction methods and biocompatibility of plant polysaccharides - Guides the reader through properties and preparation methods of plant polysaccharides as pharmaceutical excipients - Covers a broad range of cutting-edge applications, with each chapter targeting a specific use

This book covers the morphological characteristics, ethnopharmacological properties, isolated and identified structurally diverse secondary metabolites, biological and pharmacological activities of medicinal plants. Ethnopharmacology is the systematic study of folklore/traditional medicines, which continue to provide innovative drugs and lead molecules for the pharmaceutical industry. In fact, plant secondary metabolites, used as a single molecule or as a mixture, are medicines that can be effective and safe even when synthetic drugs fail. Therefore, the description of these secondary metabolites as well as methods for the targeted expression and/or purification is of high interest.In addition to surveying the morphological features, ethnopharmacological properties, biological and pharmacological activities, and studies of clinical trials, this book offers a comprehensive treatment of 56 plant species. It also presents the cell culture conditions and various methods used for increasing the production of medicinally important secondary metabolites in plant cell cultures.This volume:· Provides the morphological features, habitat, and distribution of each species of 56 genera selected from the different regions of the world. · Presents ethnopharmacological applications of various species of the 56 genera included in this book. Different species of 56 genera are used for ethnomedicinal uses by the people of various countries of the world.· Describes structures of various secondary metabolites identified in 56 plant species together with their biological and pharmacological activities.· Discusses strategies of secondary metabolites production, such as organ culture, pH, elicitation, hairy root cultures, light, and mutagenesis.· Provides a complete overview of each species of 56 genera and complete information up to 2022.Ethnopharmacological Properties, Biological Activity and Phytochemical Attributes of Medicinal Plants is an important book for undergraduate and postgraduate students, pharmacologists, phytochemists, Ayurvedic practitioners, medical doctors, and biotechnologists interested in the ethnopharmacological properties, phytochemistry, and biological and pharmacological activities of plants.

The need for state-of-the-art antimicrobial agents is greater than ever because of the development of multidrug resistance in communal pathogens, the rapid rise of new infections, and the potential for use of multidrug-resistant agents in biological protection. Although the need for novel antimicrobials is increasing, the development of such agents faces significant obstacles. Pharmaceutical research and development costs are estimated to be $400–$800 million per approved agent. The most important natural antimicrobial compounds derived from various plant sources containing a wide variety of secondary metabolites. With collected contributions from international subject experts, this volume focuses primarily on antimicrobials.This book deliberates recent developments in microbial science in combating infectious diseases and explores advances in antimicrobial constituents and their applications in the fight against bacteria. In addition, it also provides a variety of photographs, diagrams, and tables to help illustrate the material. The novel strategies to combat antimicrobial resistance are also described, emphasizing collaborative measures of control. We describe the concerted efforts undertaken by global communities to combat antimicrobial resistance in detail. The most efficient strategy could be a behavioural change towards indiscriminate consumption, usage, and prescription of antibiotics.Students, research scientists, academicians and policy makers can benefit from Antimicrobials in Pharmaceutical and Medicinal Research as a resource that addresses biotechnology, applied microbiology, healthcare/pharmaceutical products, medicinal plant products, and all disciplines related to antimicrobial research.Features of the book: Covers development in plant-based antimicrobials for sepsis management and progress Describes modern approaches for phyto-nanoconjugates in combating multidrug resistance in biomedicine Details methods to improve antimicrobial properties to have a longer service life in combating infection Describe bacteriocins and plant metabolites as biotechnological tools in food, pharmaceuticals and therapeutics applications Highlights natural antimicrobial therapeutic peptides Offers current and future applications of emerging antimicrobial technologies

Biosurfactants: Research and Development provides a thorough overview of biosurfactant research and development across a range of settings and industries, highlighting the novel use of enzymes, metabolic and genetic engineering in biosurfactant production and showcasing diverse experimental models and approaches. Sections discuss fundamental characteristics of biosurfactants, their physio-chemical properties, and their differences from chemically synthesize surfactants, different research approaches for the study of known biosurfactants, and the genetic manipulation of microorganisms to increase biosurfactant productivity, or to produce molecules with improved characteristics. Throughout the book, methods and approaches are discussed in easy-to-digest formats, with methods discussed, ranging from in silico approaches to classical biocatalysis omics analysis and metabolic engineering. - Provides a through overview of biosurfactant enzymes and microorganisms used in biosurfactant production - Features instruction in a wide range of research and development approaches, ranging from in silico techniques to classical biocatalysis omics analysis and metabolic engineering - Features chapter contributions from international leaders in the field

Contains patterns of allergic reactivity for disorders such as asthma, atopic dermatitis, urticaria, and anaphylaxis. Written by leading experts in the field, Inflammatory Mechanisms in Allergic Diseases covers non-anaphylactic drug disorders; synthesis and formation of IgE antibodies; new treatments using allergenic peptides, immunostimulatory oligonucleotides, and pharmacogenomics;recent advances targeting effector mechanisms; hypersensitivity reactions to drugs and more! With over 3100 references, tables, drawings, and micrographs, Inflammatory Mechanisms in Allergic Diseases is an essential reference for allergists, pulmonologists, immunologists, dermatologists, ophthalmologists, otolaryngologists, internists, pediatricians, family practitioners, and medical students in these disciplines.

Understand forest responses to climate change with this timely introduction Forests are among the most critical parts of our global ecosystem, responsible for the air we breathe, home to most of the earth's species, and crucial sources of food and raw materials. Forest development is therefore one of the most important areas of ecological study, and damage to forests is potentially existential. Metabolomics, a toolkit which accrues data on interactions between genetic and environmental conditions, promises to advance our understanding of how these vital ecosystems respond to dramatic changes in climate and environment. Monitoring Forest Damage with Mass Spectrometry-Based Metabolomics Methods offers a thorough, accessible discussion of metabolomic techniques and their applications in forest tree research. It promises to enrich the reader's understanding of how forests are being transformed by globe-spanning changes, and to arm researchers with tools for reacting to these potentially epochal developments. Monitoring Forest Damage with Mass Spectrometry-Based Metabolomics Methods readers will also find: Analysis of specialized secondary metabolites such as phytohormones Detailed discussion of ecologically important tree genera such as Pinus, Populus, Quercus, and many more Supplementary materials related to study design, sample preparation, and instrumental analysis protocols Monitoring Forest Damage with Mass Spectrometry-Based Metabolomics Methods is ideal for researchers in analytical chemistry, mass spectrometry, metabolomics, forest research, the life sciences, and all other related fields.

Current Cancer Biomarkers is a comprehensive review on the status of biological markers for various types of cancer. It aims to update readers on current developments on the subject. The contents are divided into 5 sections covering a wide range of biomarkers and their diagnostic applications. The range of tumour biomarkers referenced here gives insights into molecular mechanisms behind cancer, including initiation, development, progression, prognosis, response to the therapeutic modalities, recurrence, and point-of-care application to detect cancer. Key features- Introduction of the basic features of cancer markers- Comprehensive and updated coverage of potential and effective biomarkers including genomic, epigenomic, transcriptomic, proteomic, cellular and morphologic factors- Information on biomarkers in many types of cancers including breast cancer, colorectal cancer, skin cancer, leukemia, liver cancer and prostate cancer- Applications of biomarkers in cancer diagnosis- Structured contents with easy-to-understand sections and headings- References for advanced readers The updated information about different aspects of cancer markers in the experimental and clinical setting will enrich the reader's understanding of the disease. The information serves as a resource to help in better management of cancer patients and understanding cancer biology when planning medical research projects. The book is intended as a reference for a diverse audience: biomedical science students, medical students, academics, researchers, clinicians and multidisciplinary teams involved in cancer management and research.

This book brings together chapters related to sustainable utilization of biological resources, including in situ and ex situ conservation of rare, endangered, and threatened plants. The title also gives a special emphasis on marine sponges and mangrove ecosystems, which are two important untapped potential resources of the marine ecosystem and play a key role in maintaining the marine ecosystem. There is an urgent need for the conservation, exploration and utilization of bioresources for the growth and survival of human beings. Due to the significant reduction in biological resources, many countries are developing strategic action plans for the conservation and sustainable use of biological resources. That is where this book fills the gap by discussing the significant development of new products and methodologies for sustainable utilization of these resources. This book also unveils a world of novel bioactive molecules from medicinal plants and the marine ecosystem and explains how drug design pipelines can advance modern drug development. The target audiences for this book include biodiversity researchers who are working on technology and bioresource management issues and faculty and students in the environment research areas and Biodiversity conservation.

'Prematuridade - Desenvolvimento Neurológico e Motor, Segunda Edição, apresenta, de forma descritiva, clara e objetiva, reflexões atuais, fundamentadas pela ciência, sobre a assistência adequada ao prematuro. Precursora da assistência motora dentro da unidade de terapia intensiva neonatal, a autora aborda a avaliação e o tratamento das disfunções sensório-motoras, com foco na prematuridade. De leitura fácil e didática, a obra discorre, ao longo de 11 capítulos, sobre as bases teóricas do desenvolvimento e da intervenção terapêutica, tratando de temas como Plasticidade Neuronal, Crescimento e desenvolvimento Motor do Recém-Nascido Prematuro, Programas Intervencionais na UTI Neonatal, Programa ISME: Intervenção Sensório-Motora Essencial, Protocolo de Triagem Neuromotora Neonatal. Trata-se de uma obra que terá grande utilidade para diversos profissionais que lidam com os cuidados ao prematuro em risco. De maior utilidade para fisioterapeutas, fonoaudiólogos, terapeutas ocupacionais, enfermeiros, intensivistas pediátricos e médicos em geral. É, sem dúvida, um material que permitirá aos profissionais da Saúde proporcionar mais qualidade no atendimento aos pequeninos que, chegando mais cedo ao mundo, necessitam de cuidados especiais para alcançarem qualidade de desenvolvimento.'

Natural Plant Products in Inflammatory Bowel Diseases: Preventive and Therapeutic Potential organizes all evidence to understand which natural products are the first steps of investigation and which have strong evidence of their effects in inflammatory bowel diseases, have been tested in clinical trials, and have received approval to be officially used. In addition to providing information regarding the research with natural products in inflammatory bowel diseases, this reference will also highlight the molecular mechanisms behind the effects of natural products in inflammatory bowel diseases with the aid of figures, video animations and dynamic tables. Compiled from research group members from different parts of the world and specialized in inflammatory bowel diseases and related topics, this important reference will be useful to health professionals, researchers, professors, and industry managers as it provides helpful information on the subject, with the potential to inspire health care, relevant research and product innovation. - Provides updated information on the pathogenesis of inflammatory bowel diseases and their pharmacological treatments and adverse effects - Delivers the most up-to-date information regarding the molecular mechanisms of natural products in inflammatory bowel diseases - Organizes the separation of natural products based on their characteristics, including lists of the main results of natural products in experiments conducted in vitro with animals, and in humans with IBDs

Encyclopedia of Soils in the Environment, Second Edition, Five Volume Set updates and expands the previous version to ensure coverage of topics relevant to current world problems such as population pressure, food security and global change. Since publication of the previous edition there has been a huge change in our ability to carry out bioinformatics related to soil organisms and their functioning. Major developments in next generation DNA sequencing techniques have made it possible to identify both the diversity of microbial populations and their functioning. Furthermore, it allows the management of microbes within the soil. Imaging is changing our perceptions and improving our knowledge of soil aggregation. This also applies to remote and proximal sensing of laboratory and field soils, which is undergoing rapid change. Soil physics is a core area of soil science, but new techniques and technology have increased our understanding of processes. This reference work covers the entire field of soil science, bridging the gap between basic science and applications, and is designed to serve students and expert researchers. It is organized around four core topics, the main components of soil science – biology, chemistry, physics and environment and management. Soil science is becoming a crucial subject as world governments realize its importance in food production, water quality, flood control, greenhouse gas management, source of antibiotics and other drugs. As such this work is of interest not only to academics but to policy makers, government researchers and the geographical and environmental community who are not necessarily in research roles but need information on soil to support their core work. - Comprehensive: chapters are written by renowned scientists with diverse expertise, providing an all-round depiction of the field. Bridges core soil science and the environment, with a focus on challenges that extend from land use to climate change - Up to date: updates and expands the previous edition. Includes developing areas of research such as soil microbiology and new techniques of investigation - Interdisciplinary: serves a wide audience, academics and professionals in disciplines ranging from fundamental earth science to ecology, agriculture, environmental health and environmental management

Research in recent years has increasingly shifted away from purely academic research, and into applied aspects of the discipline, including climate change research, conservation, and sustainable development. It has by now widely been recognized that “traditional” knowledge is always in flux and adapting to a quickly changing environment. Trends of globalization, especially the globalization of plant markets, have greatly influenced how plant resources are managed nowadays. While ethnobotanical studies are now available from many regions of the world, no comprehensive encyclopedic series focusing on the worlds mountain regions is available in the market. Scholars in plant sciences worldwide will be interested in this website and its dynamic content. The field (and thus the market) of ethnobotany and ethnopharmacology has grown considerably in recent years. Student interest is on the rise, attendance at professional conferences has grown steadily, and the number of professionals calling themselves ethnobotanists has increased significantly (the various societies (Society for Economic Botany, International Society of Ethnopharmacology, Society of Ethnobiology, International Society for Ethnobiology, and many regional and national societies in the field currently have thousands of members). Growth has been most robust in BRIC countries.The objective of this new MRW on Ethnobotany of Mountain Regions is to take advantage of the increasing international interest and scholarship in the field of mountain research. We anticipate including the best and latest research on a full range of descriptive, methodological, theoretical, and applied research on the most important plants for each region. Each contribution will be scientifically rigorous and contribute to the overall field of study.

This book presents numerous uses of biosurfactants as potential alternatives to synthetic surfactants in food, textile, biomedical and therapeutic applications as well as in bioremediation and waste management. Divided into four parts, the book explores a wide range of biosurfactants as sustainable materials, starting with an overview of biosurfactants'production, in which readers will find topics such as characterization, purification, sustainable production, biodegradation, and cytotoxic aspects of biosurfactants. Part 2 presents the latest applications of biosurfactants in food and textile industries, as well as their application in nanoparticle synthesis, heavy metal remediation, drug absorption, waste treatment, agriculture management, marine sediment remediation of organic pollutants, emulsification and biofuel production, and as anti-corrosive agents. Part 3 traces current biomedical applications of biosurfactants, including their use as biocidal, wound healing, and anti-tumour agents. In this part, readers will also discover further applications of biosurfactants in oral cavity care, and biofilm prevention and disruption. The final part of the book discusses the main advantages and disadvantages of biosurfactants over synthetic surfactants, the current challenges in biosurfactant research, and prospects for their commercialization. This book will be a valuable resource for students, scholars and researchers working in the fields of colloidal and interface science, chemistry and chemical engineering. Professionals and scholars alike will appreciate the latest research findings that it presents.

This book provides a comprehensive and up-to-date overview of all the upper and lower airways disorders and broadens their understanding by combining ENT and pulmonology disciplines. The volume opens with a general overview on the airways, before describing symptoms, infections and allergies. In addition to the upper airway tumors, specific lower, and upper airway disorders, other topics addressed by the book are pediatric lower airway disorders, sleep related breathing disorders, trauma, reflux, and interventional pulmonology. The closing part discusses the airway protection and includes a chapter on gender and pulmonary diseases. Written by experts in the fields, the book is a valuable resource for both specialists and trainees in ENT, pulmonology, and pediatrics.

This book covers the morphological characteristics, ethnopharmacological properties, isolated and identified structurally diverse secondary metabolites, biological and pharmacological activities of medicinal plants. Ethnopharmacology is the systematic study of folklore/traditional medicines, which continue to provide innovative drugs and lead molecules for the pharmaceutical industry. In fact, plant secondary metabolites, used as a single molecule or as a mixture, are medicines that can be effective and safe even when synthetic drugs fail. Therefore, the description of these secondary metabolites as well as methods for the targeted expression and/or purification is of high interest.In addition to surveying the morphological features, ethnopharmacological properties, biological and pharmacological activities, and studies of clinical trials, this book offers a comprehensive treatment of 56 plant species. It also presents the cell culture conditions and various methods used for increasing the production of medicinally important secondary metabolites in plant cell cultures.This volume: Provides the morphological features, habitat, and distribution of each species of 56 genera selected from the different regions of the world. Presents ethnopharmacological applications of various species of the 56 genera in this book. Different species of 56 genera are used for ethnomedicinal uses by the people of various countries of the world. Describes structures of various secondary metabolites identified in 56 plant species together with their biological and pharmacological activities. Discusses strategies of secondary metabolites production, such as organ culture, pH, elicitation, hairy root cultures, light, and mutagenesis. Provides a complete overview of each species of 56 genera and the complete information up to 2022. Ethnopharmacological Properties, Biological Activity and Phytochemical Attributes of Medicinal Plants is an important book for undergraduate and postgraduate students, pharmacologists, phytochemists, Ayurvedic practitioners, medical doctors, and biotechnologists interested in the ethnopharmacological properties, phytochemistry, biological, and pharmacological activities of plants.

This book explores how genetics and the new technologies in genomics have been used for conservation of plants and animals in the Neotropics. It shows the new perspective for conservation genetics beyond the use of theoretical and methods in genetics at species level and presents how genetics and genomics can be used for assessing communities. Conservation genetics and genomics are presented as a helpful field of study for resolving taxonomic uncertainties and hidden biodiversity, understanding populations and extinction risk, genetic management, wildlife forensic genetics, assessing biology and molecular ecology, assessing communities, conservation genomics and the use of conservation biology and genetics in science learning, highlighting case studies in the Neotropics. Applications of conservation genetics for management or policy, decision making, planning, and implementation of conservation practice in the Neotropics are addressed across chapters. This book will interest to researchers and students in conservation genetics and biology conservation interested in the Neotropics. Stakeholders and decision makers in conservation biology may also find this book useful.

This book is devoted to the chemistry of oil and petroleum products and covers the broad range of topics from heavy fuel oils, crude oils and (diluted) bitumen to today‘s research on asphaltenes. Recent methods are summarized and the large new groups of chemicals found in oils are identifi ed as well as described. The work points the way for a more complete understanding of the composition of petroleum. Highlights include: An update on oil fi ngerprinting New data using Fourier transform mass spectrometry, forensic tools for naphthenic acid fraction compounds in oil sand environmental samples Data on vanadium and nickel content changes in the resins of heavy oils, characteristics of their structural and group composition, and the content of heteroatomic (N, S, O) compounds Study of asphaltenes using direct molecular imaging employing atomic force microscopy (AFM) and scanning tunneling microscopy (STM) confi rming early findings of the dominance of the ‘island'molecular structure An update on the Yen-Mullins model of asphaltenes in reservoirs giving the requisite solution to the asphaltene particle size, thus resolving the gravity term for thermodynamic modeling. A modifi ed polymer solution theory, the Flory-Huggins-Zuo (FHZ) EoS, is provided to model asphaltene gradients in reservoirs. A suite of oils from the Tarim Basin, Qaidam Basin, Ordos Basin, and Liaohe Basin, China is characterized geochemically to clarify factors that can affect the concentrations and distributions of pyrrolic nitrogen compounds (PNCs) in crude oils. An update on biomarkers in crude oils Updates on mass spectrometry techniques applicable to crude oils

This book aims to serve the critical interests of the global community by supplying the most current knowledge and understanding of Covid-19 epidemiology, treatment, and prognoses. There was much uncertain and contradictory information published in the first year of the novel coronavirus. The dynamics of COVID-19 have now been realized, including the type of antibodies produced in infected patients and their limited lasting endurance. This book will set the record straight on the concept of “herd immunity” and explore the current vaccine trials taking place in different countries. This comprehensive book will illuminate recent advances regarding COVID-19 and offer a possible roadmap on how to move forward. Frontiers of COVID-19: A Pathophysiology and Epidemiology Roadmap of Novel Coronavirus Disease will be a vital and forward-looking guide for infectious disease clinicians, scientists and researchers, and students at the graduate level.

This volume gathers a selection of original articles and reviews on timely topics about the application of Taurine in human health written by members of the International Taurine Society, including COVID-19, cancer, heart disease, and diabetes, among others. Chapters are written by Taurine experts across the globe in North and South America, Asia, and Europe. A majority of the articles are based on original studies recently carried out in individual laboratories worldwide. The book is divided into eight parts, each covering a unique aspect of Taurine. Each section will highlight new research findings on Taurine and its application in various human systems, including the nervous system, immune system, and cardiovascular system, to combat disease. The first section covers COVID-19, the dominant health event of 2020. Experts will explore and clarify the potential therapeutic effectiveness of Taurine against COVID-19. The volume will promote further research into the application of Taurinein human health, and will be of use to a wide audience, including basic and clinical scientists, pharmaceutical and nutraceutical companies, and libraries.

This book provides a comprehensive text and reference guide for livestock production, health, nutrition, and crop mixed farming. Although there are many foreign books available on this subject, they are prohibitively expensive and written in a complex manner. Therefore, this book is both useful and accessible to students, teachers, scientists, and industry professionals working in animal production and general animal health management, as well as crop mixed farming for nutritional security. The books authors are esteemed researchers and professors from various veterinary and agricultural colleges and ICAR research institutes across the country. The book covers a wide range of topics related to livestock farming, health, and production, and also includes insights into crop mixed farming and aquaculture. It is unique in its approach, catering to the needs of its reader community and offering solutions to various problems related to livestock farming and agriculture.

This book is a collection of high-quality peer-reviewed research papers presented at International Conference on Recent Trends in Computing (ICRTC 2021) held at SRM Institute of Science and Technology, Ghaziabad, Delhi, India, during 4 – 5 June 2021. The book discusses a wide variety of industrial, engineering and scientific applications of the emerging techniques. The book presents original works from researchers from academic and industry in the field of networking, security, big data and the Internet of things.

This book collects information about the most popular ethnomedicinal plants, which are common in Turkey and around the world. It presents the ethnopharmacological records, in vivo and in vitro studies, side effects, chemical compositions and clinical studies of these medicinal plants. Its special focus is on the novel drug targets for disease and their possible mechanisms of action. It covers botanical descriptions the status of the plants, and food or drug interactions including precautions and warnings about the plants and the available market products. It provides an explanation of recorded and known plant administration dosages. Also, the gap between the traditional practice and scientific/clinical evidences in the use of ethnomedicinal plant is acknowledged.It is well known that traditional knowledge of the use of the medicinal plants in therapy is an important resource for the discovery of novel treatment options and drug targets. The main purpose of this book is to draw attention to ethnomedicinal plant species. Data on the therapeutic potentials of these medicinal plants can now be accessed from a single source. It provides an important resource for future research opportunities for harnessing the full potential of these plants.

This reference book provides a comprehensive overview of natural gums, resins, and latexes of plants with a focus on their chemistry, biological activities, and practical uses. The content is divided into five main sections each of which contains chapters contributed from valuable experts in their field. Naturally occuring plant products have quite diverse applications in many different industries. The book aims to highlight the important aspects of plant-based gums, resins and latexes as well as provide a strategic framework for further research and development activities on these bioproducts. It will appeal to a broad audience such as biologists, pharmacologists, pharmacists, food technologists and medical practitioners. It is also a useful resource for research investigators of the healthcare industry, academia and students of biomedical sciences.

This comprehensive, up-to-date reference work compiles the scientific research on the relationship between various forms of cancer and reactive oxygen species (ROS). It is well known that ROS play a key role in the various steps leading to malignancy, this includes increase in DNA mutation rates. The book brings together exciting reviews, written by leading experts all over the world. The book is divided into four broad sections. Each section describes the role of oxidative stress and underlying mechanisms and pathways, at various stages of cancer, including its role in carcinogenesis, cancer progression and metastasis. Further, the book describes how the reactive oxygen species (ROS) modulate gene expression and signal transduction pathways in cancer. The book discusses the ways to interfere with the cancer progression, and design of anti-cancer drugs. The book provides an integrated approach for better understanding of the development phases of oxidative stress-induced cancers, and mainly the current perspectives about mechanistic aspects of cancer initiation, progression and metastasis. It is a highly resourceful book and would be extremely important to clinicians, students and researchers in the field of cancer genetics, therapeutics and oncology.

This collection of chapters describes in detail the physical therapy research in patients with various types of cancers to help medical professionals and physical therapists help improve the physical function, activity of daily living, quality of life, the survival rate in cancer patients and cancer survivors. It provides not only information on rehabilitation but details on physical therapy cancer research and research methods. The book provides practical skills to treat the patients and to create useful and effective physical therapy programs by giving step-by-step tutorials to help readers learn various techniques. Along with presenting an introduction to physical therapy of cance and new findings, the authors provide recommendations on each cancer therapy. Physical Therapy and Research in Patients with Cancer is aimed at physical therapists and student physical therapists. Undergraduate and postgraduate students also can use our book to understand the basics and get up-to-date information. By sharing the latest research with our readers, the book creates a foundation for further development in this field of study.

This book explores recent advances in the microbial production of xylitol and its applications in food and medical sector. Xylitol is an important biomolecule from lignocellulose biorefinery which is produced from the xylose by chemical reactions or microbial fermentation methods. Currently, the demand of xylitol at commercial scale is being met through chemical methods. However, recent breakthroughs made in plant cell wall destruction, genetic engineering to develop the designer microorganisms, fermentation methods and media formulations and downstream processing have led the ways for sustainable production of xylitol at commercial scale in lignocellulose biorefineries. Microbial production of xylitol is preferred over the chemical processes as it is environmentally friendly, higher process efficiency with the desired product yield, and product recovery with minimum impurities. This book is a unique compilation of 11 book chapters written by experts in their respective fields. These chapters present critical insights and discuss the current progress and future progress in this area into fermentative xylitol production.Chapter 9 is licensed under the terms of the Creative Commons Attribution 4.0 International License. For further details see license information in the chapter.

Filling a gap in literature, this concise and practical book presents the principles of virtual orthopedic assessment and shares insights into the use of technology for distance patient-physician communication. Offering expert know-how and best practices, it equips readers with essential information on how to best remotely manage the diagnosis, treatment and follow-up of patients.The book starts by defining telemedicine and presenting the basic requirements. The following chapters each focus on a specific joint or compartment, highlighting its peculiarities in terms of remote clinical assessment, and also discussing data security, patient confidentiality and consent as well as medico-legal issues. Moreover, the book features a dedicated chapter that analyzes specific issues related to remote assessment in children, older patients, noncompliant patients, and patients with pain. Covering all the basic and practical aspects of this emerging field, this book is a must-read for orthopedists and other professionals, such as general practitioners and physiotherapists, wanting to gain insights into remote orthopedic patient care.

This book is about relevant recent research topics in understanding aquaculture for practical approaches; aquatic science, engineering, feed and nutrition, immunology and health are reviewed. The book includes information on why certain fish strains differ in disease resistance, all the current data on fish cell populations, the regulation of the response by factors, and the major histocompatibility complex are explained in detail. The book contains the chapters on nutrition, feed and feed additives, ecology, immunology, microbiology, toxicology, biochemistry, nanotechnology, pharmacology, and biotechnology, among other fields of basic and applied research. Over the past era, scientists have recognized the importance of nutrition in maintaining the health of humans and other animal species, including fish. Humans and other terrestrial animals were the focus of previous research on the links between nutrition, immune response, and disease resistance. However, attempts to conduct similar studies using fish have met with limited success in the last two decades due to a lack of understanding of the immune response in fish. In most facilities, the animals are kept at relatively high densities, causing stress and disease problems are the challenges that we face today and this book opens up the exciting new area of research to truly understand the relationship between fish genetics and immune reactivity. The aquatic immune system turns out to be a crucial reference as aquatic products are increasingly used as model systems for vertebrate immune systems. This book provides that the research students and scientists with a useful text on the latest knowledge of the aquatic feed and nutrition, immune system, cutting-edge technologies, draws everyone's attention to the practice of small-scale aquaculture and provides a guide on how to responsibly use the water ecosystem and the steps needed to develop, test and market fish vaccines. The chapters will serve as introductions to these fields and up-to-date reviews of recent research advances. This book is intended for a wide range of readers, including nutritionists, disease specialists, feed formulators, students, extension specialists, and farmers, as well as university teachers, graduates and doctoral students in zoology, physiology, aquaculture, and biology in general.

Die febrile Neutropenie ist eine der schwerwiegendsten Nebenwirkungen der in der Tumortherapie eingesetzten Medikamente. Sie stellt eine potentiell tödliche Komplikation dar und wird als onkologischer Notfall betrachtet. Durch Neuentwicklungen auf dem Gebiet der supportiven Therapie lassen sich (febrile) Neutropenien besser vermeiden und auftretende Infektionen erfolgreicher behandeln. Dosisreduktionen und Zyklusverschiebungen können dadurch meist vermieden und die Chemotherapie nach Plan durchgeführt werden. Hierdurch kann das Überleben der Patienten verbessert werden. In dieser aktualisierten Neuauflage werden die Grundlagen der Neutropenie, die infektiologischen Aspekte und der Einsatz hämatopoetischer Wachstumsfaktoren detailliert behandelt. Ziel ist es, den klinisch Tätigen einen schnellen Einblick in die aktuellen Vorgehensweisen bei neutropenen Patienten zu geben.

This book is quick guide on the hematopoietic stem cell transplant (SCT), also called bone marrow transplant (BMT) - an evolving field of hematology and hemato-oncology. This book covers the various types of stem cell transplants like autologous and allogeneic stem cell transplants, indications, ways of doing a transplant, and stem cell transplants basic principles. Written in a question-answer format, readers will find it more interesting as one question sequentially leads to another. This book explains the complications of SCT in individual chapters along with the biology of T cells which are the most important cells involved in the success of SCT This book is beneficial to the budding hematologists, oncologists, and postgraduates interested in SCT and helps students in their exams. The book would be helpful for readers globally as SCT is a procedure done worldwide and is an ever-increasing field for treating various benign and malignant hematological diseases.

This book provides an update on recent clinical practice and an in-depth view of selected topics relevant to hospital medicine. It is divided into four sections that explore clinical, administrative, systems and ethical issues. Each section places an emphasis on the opportunities, challenges and potential directions of this bourgeoning subspecialty. This new edition expands on topics covered in the previous edition, including the COVID-19 pandemic, racial disparities in healthcare delivery and providers, and pediatric hospital medicine. Other chapters explore worldwide practice patterns and practical application of philosophical tools in daily practice. This up-to-date resource provides hospitalists, advanced nurse practitioners, medical students and administrators with the latest research, trends and issues in hospital medicine.

SCHALM'S VETERINARY HEMATOLOGY An updated guide to veterinary hematology with expanded coverage on a variety of topics The revised seventh edition of Schalm's Veterinary Hematology is updated to provide a comprehensive review of all topics related to disorders of the blood in animals. Designed as a gold-standard reference, this text covers a wide range of species in both confined and free-range populations, reflects the most recent trends in hematology diagnostics, and discusses recent advances in traditional techniques. Edited and written by an international team of experts in the field, the book represents an accessible yet in-depth resource for information on veterinary hematology. The new edition includes a hemolymphatic tissue section that covers current understanding of basic science and the species-specific hematology section is further expanded from previous editions. New chapters address emerging topics in hematology, and existing chapters have been revised and rearranged to improve readability and simplify access to the material. This seventh edition: Updates the most complete reference on veterinary hematology across species Contains a new section on basic biology of hemolymphatic tissues Expands coverage of species-specific hematology Presents new and emerging topics in blood disorders and diagnostic techniques Features a reorganized contents list for an integrated, easy to use reference Written for veterinary clinical pathologists and residents, diagnostic laboratory staff, internists, and specialists, Schalm's Veterinary Hematology is the most comprehensive and up-to-date reference on the topic.

Selected as a Doody's Core Title for 2022! Defining the field of immunology for 40 years, Paul's Fundamental Immunology continues to provide detailed, authoritative, up-to-date information that uniquely bridges the gap between basic immunology and the disease process. The fully revised 8th edition maintains the excellence established by Dr. William E. Paul, who passed away in 2015, and is now under new editorial leadership of Drs. Martin F. Flajnik, Nevil J. Singh, and Steven M. Holland. It's an ideal reference and gold standard text for graduate students, post-doctoral fellows, basic and clinical immunologists, microbiologists and infectious disease physicians, and any physician treating diseases in which immunologic mechanisms play a role.