Search

Combine the surprising truth about brain food with the cutting-edge science of brain metabolism to achieve extraordinary improvements to your emotional, cognitive, and physical health.​ Are you struggling with attention problems, mood swings, food obsession, or depression? Whatever the issue, you have far more control over your thoughts, feelings, and behavior than you realize. Although medications may bring some relief, in Change Your Diet, Change Your Mind, Dr. Georgia Ede reveals that the most powerful way to change brain chemistry is with food, because that's where brain chemicals come from in the first place. In this provocative, illuminating guide, Dr. Ede explains why nearly everything we think we know about brain-healthy diets is wrong. We've been told the way to protect our brains is with superfoods, supplements, and plant-based diets rich in whole grains and legumes, but the science tells a different story: not only do these strategies often fail, but some can even work against us. The truth about brain food is that meat is not dangerous, vegan diets are not healthier, and antioxidants are not the answer. Change Your Diet, Change Your Mind will empower you to: understand how unscientific research methods drive fickle nutrition headlines and illogical dietary guidelines weigh the risks and benefits of your favorite foods so you can make your own informed choices about what to eat evaluate yourself for signs of insulin resistance—the silent metabolic disease that robs your brain of the energy it needs to thrive improve your mental health with a choice of moderate-carbohydrate and ketogenic diets that you can personalize to your food preferences and health goals Drawing on a wide range of scientific disciplines including biochemistry, neuroscience, and botany, Dr. Ede will ignite your curiosity about the fascinating world of food and its role in nourishing, protecting, and energizing your brain.

This book reviews the relationship between cytokines, glia, and neurons in the pathophysiology of neuropsychiatric disorders and examines the mechanisms of action of the drugs used for the treatment of these disorders. Increasing evidence has suggested that glia perform important roles in various brain functions, but much remains to be learned about these crucial cells and their interplay with neurons. In addition, a better understanding of the interaction between inflammatory mediators, such as cytokines, and the activated immune response will be of critical importance for the development of new therapeutic strategies. These key areas are the focus of this book, which documents the latest research findings in the field. Evidence is provided for the role of inflammation-induced toxic metabolites from the tryptophan pathway in a wide range of neuropsychiatric disorders, including depression, schizophrenia, and Alzheimer's disease. In presenting state of the art knowledge on the interactions between cytokines, glia, and neurons, the book will help to pave the way for the development of novel targets for the prevention and treatment of neuropsychiatric disorders.

Chronic pain seldom presents alone. Pain patients frequently have comorbid psychiatric conditions and those suffering from mental illness often experience pain. Nonetheless, pain conditions and psychiatric disorders have customarily been understood and treated as different and separate clinical entities, to the detriment of patients'wellbeing. This book will describe the complex and striking relationships between pain and psychiatric disorders, offering the first comprehensive review of the challenging and neglected intersection between pain medicine and psychiatry. Written by world-renowned experts in the fields of pain and psychiatry, chapters contribute a valuable array of clinical and theoretical perspectives and include illustrative case examples throughout.

This book reviews key recent advances and new frontiers within psychiatric research and clinical practice. These advances either represent or are enabling paradigm shifts in the discipline and are influencing how we observe, derive and test hypotheses, and intervene. Progress in information technology is allowing the collection of scattered, fragmented data and the discovery of hidden meanings from stored data, and the impacts on psychiatry are fully explored. Detailed attention is also paid to the applications of artificial intelligence, machine learning, and data science technology in psychiatry and to their role in the development of new hypotheses, which in turn promise to lead to new discoveries and treatments. Emerging research methods for precision medicine are discussed, as are a variety of novel theoretical frameworks for research, such as theoretical psychiatry, the developmental approach to the definition of psychopathology, and the theory of constructed emotion. Theconcluding section considers novel interventions and treatment avenues, including psychobiotics, the use of neuromodulation to augment cognitive control of emotion, and the role of the telomere-telomerase system in psychopharmacological interventions.

This book reviews all the important aspects of treatment-resistant psychiatric disorders, covering issues such as definitions, clinical aspects, neurobiological correlates, treatment options, and predictors of treatment response. The book is divided into three sections, the first of which examines the most recent thinking on treatment resistance in psychiatry, including definition and epidemiology, paradigm shift in the study of the subjects, individual susceptibility and resilience, abnormal structural or functional connectivity, and insights from animal models. The second section then discusses treatment resistance in each of the major psychiatric disorders, with particular focus on the responsible clinical and biological factors and the available management strategies. Finally, more detailed information is presented on diverse pharmacological and non-pharmacological therapeutic interventions. The book, written by leading experts from across the world, will be of value to all who seek a better understanding of the clinical-neurobiological underpinnings and the development of management for treatment resistance in psychiatric disorders.

This book, in two volumes, focuses on contemporary issues and dilemmas in relation to depression. The aim is to equip readers with an up-to-date understanding of the clinical and neurobiological underpinnings of depression, the clinical manifestations, and the development of more effective treatments. This second volume is devoted specifically to clinical and management issues. Readers will find detailed information on a wide range of frequently encountered and more complicated clinical presentations, with examination of risk factors and links to other conditions. Diagnostic aspects, including progress toward biological classification and the role of neuroimaging, are explored. Current trends in therapy are examined at length, drawing on the latest evidence and covering not only antidepressant medications but also the roles of neurostimulation, combined pharmacotherapy and psychotherapy, mindfulness-based cognitive therapy, and complementary and alternative medicine. The companion volume is dedicated to the underlying biomedical and neurobiological basis of depression. Understanding Depression will be an excellent source of information for both researchers and practitioners in the field.

This new book provides research summaries from a number of different focuses in this important field, as well as compiles biographical sketches of top professionals in the field of biochemistry research.

This book focuses on risk factors, clinical and biological characteristics, and treatment options for depression. The aim of this book is to provide readers with an up-to-date understanding of the clinical and neurobiological underpinnings of depression as well as promising treatment for depression. The book is divided into five sections, the first of which examines the clinical heterogeneity of depression. Clinical symptoms, risk factors and treatment options of depression during neurodevelopment and neurodegeneration periods differ from those of depression in adults. Section II highlights bio-psychosocial factors in depression. Major depression cannot be understood without considering the psychosocial environment. Interaction between genetic susceptibility and the psychosocial context affect the occurrence of major depression. Section III focuses on biomarkers of depression. It covers from the overview of biomarkers, focusing on diagnosis, subtyping of depression and treatment response prediction to neuroimaging, genetics, and serum markers in depression. Section IV covers neurobiology and management for treatment-resistant depression. It discusses the etiological issues of treatment-resistant depression including genetic susceptibility, structural and functional MRI markers, neurogenesis, neuroinflammation and neuromodulation treatment for treatment-resistant depression. Section V highlights new perspectives of depression. Neurotrophic hypothesis-driven BDNF-TrkB signaling pathways and downstream of neurotransmitters have attracted attention to new pharmacologic targets. Homeostatic regulation of sleep, its dysregulation in mood disorders, and updated theories between inflammations and depression are discussed. The book will provide a better understanding of clinical and biological features and the management of depression, and will also function as a step onto the path toward the ultimate goal of predicting, preventing and treating depression.

Tryptophan is not only an essential amino acid but also an effective signaling molecule as an indicator of amino acid sufficiency. Serotonin is biosynthesized from the essential amino acid tryptophan. The first chapter of this book deals with the effects of tryptophan as well as some strategies of treatments that modify serotonin levels on cognitive processes during aging and neurodegenerative diseases. The changes of tryptophan metabolism under immunological challenges and physiological conditions like stress are examined as well. In the third chapter, the authors illustrate the key role of L-tryptophan in metabolic functions with special emphasis on the alterations of circadian rhythms. The remaining chapters of the book focus on new research findings on L-tryptophan synthesis from D-serine; the complex experimental and theoretical studies of the tryptophan molecule in its collisions with low and high energy electrons; and finally, a commentary on a novel tryptophan-selective amino acid transporter that is functionally coupled to ID01-dependent signaling pathways.

Over the centuries, naval relations between Japan and Korea appear to have alternated between peaceful trade and outright hostility. However, this impression can be misleading, as much of what passed for mercantile activity was in fact conducted by Japanese pirate fleets, who pillaged the coasts of Korea and China in a long-lasting tradition that culminated in the greatest pirate raid of all: Hideyoshi's invasion of Korea in 1592. This was the conflict that involved Ming China and almost dragged in Siam. It also led to Korea developing East Asia's most famous warship: the legendary turtle ship, which is described for the first time in full technical detail in this book.

This new book offers a retrospective appraisal of the Gwangju Uprising by academics, activists and artists from Gwangju, Korea. In 1980, South Koreans took to the streets to demand democracy. When the military threatened brutal suppression of the popular movement, only in Gwangju did people refuse to submit. After horrific bloodshed, the citizens of Gwangju drove the military out of the city and held their liberated space for a week. As a'beautiful community'emerged, newspapers were published, hundreds of thousands of people congregated in popular assemblies, and the city's life gave new meaning to democracy. Although crushed by overwhelming military force, Gwangju's example inspired the eventual overthrow of the military dictatorship and ushered in a new democratic wave in East Asia. Providing a detailed analysis of the events of the Gwangju uprising, this new volume traces the birth of South Korean democracy in Gwangju's stubborn refusal to accept life without freedom. The book also focuses on the socio-economic background, the role of women in the uprising, issues of collective identity and the international significance of the revolt. Scholars and researchers of South Asian politics, social movements, history, democracy and development studies will find this volume to be of keen interest.