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Drug Discovery Stories: From Bench to Bedside presents a collection of cases on the development of highly successful pharmaceuticals. It delves into the realm of drug discovery, exploring the structural biology and biological functions of the sought-after targets. The book covers the identification of promising compounds, their transformation from hits to leads through meticulous optimization, and the elucidation of how key compounds interact with the target (in essence, providing invaluable insights for drug design). Additionally, it covers essential information such as the pivotal biological and PK data of lead compounds, any noteworthy clinical results, and a comprehensive overview of other candidate compounds. The field of drug discovery and development has experienced rapid evolution, with numerous new drugs receiving approval each year. While several books have been published on this subject, there is a pressing need for a new book series that accurately reflects the current advancements in drug discovery. This book aims to not only cater to the drug discovery community but also engage other communities involved in chemical biology, synthetic chemistry, and pharmacology. - Analyzes the drug discovery stories of different blockbuster drugs - Includes the newly approved drugs - Covers key aspects related to the drug development of the drugs

Since the emergence of 2022's monkeypox virus (MPXV) outbreak, it has been the heading of news and research articles that MPXV is being involving non-endemic areas after about its 80-year presence in endemic areas. Efforts are concentrated on understanding how MPXV has evolved to cause an epidemic. The book provides a comprehensive compendium of chapters on poxviruses in different domains. It concludes that the main problem we should deal with is not to address how MPXV has overcome the distance between non-endemic and endemic areas, but it is the non-cooperativity of logistics, research, and science in managing poxviruses'outbreaks.

This reference book provides an overview of the active ingredients of selected plants present in beverages. The book aims to highlight according to the chapters the botanical, ethnobotanical, ecological or agronomic aspects of these botanical species used in some well-known or rarer beverages by linking them to their phytochemistry. This book also covers the manufacturing techniques, as well as the quality control of these products of natural origin in beverages. The content is divided into five main sections containing chapters written by valuable experts in their field : (1) beverages plants with caffeine and other methylxanthines, (2) beverage plants without caffeine, (3) fruits juices, (4) alcoholic beverage plants: non-distilled beverages and (5) alcoholic beverage plants: distilled beverages. The book is a useful resource for graduate students, academics and researchers in the field of botany, agriculture, food chemistry, nutrition as well as for industrial scientists and those involved in the commercialization of phytochemicals, plants and their extracts.

This book advances the knowledge of the mechanism development of a lived organism during its lifetime through the normal stationary state and quasi-stationary pathologic state from the viewpoints of biochemistry, biophysics, and thermodynamics. It explores the possibility of estimating experimental results from the three points of view, giving a broad perspective on the interaction between an organism and its environment. The book also describes the biophysical and biochemical mechanisms'maintenance stability of internal energy according to the First and Second Law of Thermodynamics.

This reference work covers general concepts of anti-viral metabolites, classifications, ethnopharmacology, chemistry, clinical and preclinical studies focusing on different medicinal plants against various types of viral infections. Various plants have been used in medicine since ancient times and are known for their strong therapeutic effects. The book will describe potential antiviral properties of medicinal plants against a diverse group of viruses, and provide an insight to the potential plants possess for broad-spectrum antiviral effects against emerging viral infections. The book aims to target a broad audience including virologists, molecular biologist, microbiologist and scientists working with natural products as well as researchers, students, healthcare experts involved in pharmaceutical and medical field.

Develop your own unique healing protocol for Long Covid• Discusses how to deal with the symptoms of Long Covid, from brain fog and headaches to hormonal dysregulation, immune malfunction, and limbic system dysfunction, to histamine intolerance to certain foods and more• Presents medicines and methods ranging from pharmaceutical, herbal, and homeopathic remedies to breathwork practices, detox therapies, lymph drainage exercises, shamanic techniques, and neuroplasticity retraining• Explores techniques for accessing one's own intuition for remedies and how to combine them with modern medicineEarly in the pandemic, Vir McCoy contracted Covid-19, which developed into post-acute sequelae of Covid (PASC), commonly known as long Covid or long-haul Covid. As a medical intuitive and scientist he began collecting both intuitive information and extensive scientific and medical research about the nature of long-haul Covid. Integrating his intuitive impressions with other protocols and support group success stories, he developed this comprehensive healing guide for successful recovery options from long Covid.The author discusses the primary symptoms and predispositions of long Covid and outlines the basic steps for dealing with each of them, including brain fog, tinnitus, loss of smell and hair, debilitating headaches, hormonal dysregulation, immune malfunction, limbic system dysfunction, gut issues, mental instability, sleeplessness, and intolerance to certain foods. Backed up by more than 350 scientific references, he presents medicines and methods for healing long Covid, ranging from pharmaceutical, herbal, and homeopathic remedies to breathwork practices, detox therapies, lymph drainage exercises, gut biome restoration, neuroplasticity retraining, immune modulation, and shamanic techniques as well as meditations and mantras for calming the limbic system and the PTSD that can accompany chronic illness.Detailing the art of “intuitive access,” the author teaches how to discover your own unique remedies and presents a guide for incorporating these intuitive therapies with modern medical treatments and other healing strategies. He also explores the deeper significance of disease and how the “disease” may be teaching us something greater: a way to reclaim our power.

The South African Herbal Pharmacopeia: Monographs of Medicinal and Aromatic Plants is a collection of 25 original monographs of medicinal plants that are currently under commercialization or have the potential for commercialization into herbal medicinal products for the global marketplace. Chapters include a general overview covering synonyms, common names, conservation status, botany, geographical distribution, ethnopharmacology, commercialization, pharmacological evaluation, chemical profiling and quality control, including HPTLC fingerprint analysis, UPLC analysis, gas chromatography and mid-infrared spectroscopy analysis. Academics researching pharmacy and analytical chemistry will benefit from the detailed chemical profile on each species presented. Industrial manufacturers of herbal products, herbal medicines, cosmetics, food supplements, and national and international policymakers and regulators will benefit from the overview provided at the beginning of each chapter. - Provides a comprehensive, up-to-date literature review on 25 medicinal plants of South Africa - Documents quality control protocols for chemical fingerprinting and biomarker identification in plant material - Includes updated safety profiles of medicinal plants

Coronavirus Drug Discovery, Volume Three: Druggable Targets and In Silico Update presents comprehensive information on drug discovery against COVID-19. Chapters in Part One of this volume describe the various druggable targets and associated signaling pathways for effective targeting of SARS-CoV-2. In Part Two, chapters discuss the various computational approaches and in silico studies against SARS-CoV-2. Written by global team of experts, this book is an excellent resource that will be extremely useful to drug developers, medicinal chemists, pharmaceutical companies in R&D, research institutes in both academia and industry, and the National Library of Medicines and Health. In addition, agencies such as the National Institutes of Health, Centers for Disease Control and Prevention, World Health Organization, European Medicines Agency, the US Food and Drug Administration, and all others involved in drug discovery against COVID-19 will find this book useful. - Discusses the pathogenic mechanisms of SARS-CoV-2 and druggable targets - Reviews the various signaling pathways associated with SAR-CoV-2 as possible druggable targets - Presents computational approaches and in silico studies against SARS-CoV-2

Given novel infectious diseases such as COVID-19 and antibiotic resistance new antimicrobial discovery is an important research area. Considering that nature is a vast source of bioactive molecules with antimicrobial activity, the main aim of this book is to present a comprehensive outlook of current research in the field of natural antimicrobials. It discusses the antimicrobial activity of medicinal plants, beehives, and mushrooms with a global coverage of antimicrobial agents from rich forests of Brazil (Amazon), North-Eastern forests of Peru, Argentina, Colombia, India, Bangladesh, Nepal, Middle East, Turkey, Croatia, Greece, Germany and Russia.The book covers the results of the in vitro screening of antimicrobial activities of extracts and isolated compounds from natural origins. It is divided into three sections: i) Section I, includes natural antimicrobials from plants; ii) Section II incorporates antimicrobial agents/secondary metabolites from plants, and(iii) Section III focuses on antimicrobials from mushrooms, beehive and delivery systems for different types of antimicrobials.Promising Antimicrobials From Natural Products is immensely useful for post graduate students, researchers in plant science, microbiology, biotechnology, pharmacology, pharma companies and those who are interested in herbal, eco-friendly, cost-effective and sustainable antimicrobials

Sie sind durch eine Krankheit geschwächt, haben ein schwaches Immunsystem und wollen es daher gezielt stärken? Sie wissen nicht, wo Sie anfangen sollen und sind überfordert? Sie sind unglücklich und kommen ohne Hilfe nicht an Ihr Ziel? Abwehrkräfte gezielt stärken - Die Heilpflanzen und Heilkräuter in diesem Buch schaffen Abhilfe. Sie werden auf einfache und verständliche Art und Weise die Bedeutung unterschiedlichster Heilpflanzen in Zusammenhang mit Ihrem Immunsystem verstehen. Mit diesem Bewusstsein und den Rezepturen können Sie gezielt Ihre Abwehrkräfte stärken und gesünder leben. Spätestens seit der Corona-Pandemie beschäftigen sich Menschen tagtäglich mit dem Immunsystem - sei es direkt oder indirekt. Doch niemand gibt Ihnen das Wissen, welches Sie ganz gezielt brauchen. Auch Sie wissen, wie wichtig ein intaktes und starkes Immunsystem ist. Ob Schnupfen, Herpes, Rheuma oder Corona: Wenn Sie unter geschwächten Abwehrkräften leiden, bekommen Sie nicht selten einen Infekt nach dem nächsten. Auf Dauer kommt es dadurch nicht nur zur Senkung Ihrer Lebensqualität, sondern auch die Anfälligkeit für weitere Erkrankungen nimmt zu. Das Wissen über die richtige Kombination verschiedener Heilpflanzen und Ihre Wirkung auf den Körper ist eine Möglichkeit für Sie, um Ihr Immunsystem zu stärken und vor weiteren Infekten und Viren geschützt zu sein. Heilpflanzen für ein starkes Immunsystem bietet Ihnen jetzt die Möglichkeit, dieses Wissen in einfacher und übersichtlicher Form einzusehen und zu Ihrem Vorteil zu nutzen. Tauchen Sie ein in diese geheimnisvolle Welt und stärken Sie jetzt Ihre Abwehrkräfte!

This book series brings updated reviews to readers interested in advances in the development of anti-infective drug design and discovery. The scope of the book series covers a range of topics including rational drug design and drug discovery, medicinal chemistry, in-silico drug design, combinatorial chemistry, high-throughput screening, drug targets, recent important patents, and structure-activity relationships. Frontiers in Anti-Infective Drug Discovery is a valuable resource for pharmaceutical scientists and post-graduate students seeking updated and critically important information for developing clinical trials and devising research plans in this field. The eighth volume of this series features 8 chapters that cover methods for antimicrobial drug discovery (with 2 chapters that focus on genomics) as well as updates on drug development against Helicobacter pylori and emerging coronaviruses, among other interesting topics: - Eradication of Helicobacter pylori Infection with Non-Bismuth Quadruple Concomitant Therapy - Drug Discovery Strategies Against Emerging Coronaviruses: A Global Threat - Opportunities Offered By Fragment-Based Drug Design in Antibiotic Development - Phage therapy as a Tool for Control of Foodborne Diseases: Advantages and Limitations - Subtractive Genomics Approaches: Towards Anti-Bacterial Drug Discovery - Recent Advances in the Discovery of Antimicrobials through Metagenomics - Phyto-Nano-Antimicrobials: Synthesis, Characterization, Discovery, and Advances - Aptamers as Anti-infective Agents

Studies in Natural Products Chemistry, Volume 66 covers the synthesis, testing, and recording of the medicinal properties of natural products, providing cutting edge accounts of the fascinating developments in the isolation, structure elucidation, synthesis, biosynthesis, and pharmacology of a diverse array of bioactive natural products. Natural products in the plant and animal kingdom offer a huge diversity of chemical structures that are the result of biosynthetic processes that have been modulated over the millennia through genetic effects. With rapid developments in spectroscopic techniques and accompanying advances in high-throughput screening techniques, it has become possible to isolate and determine the structures and biological activity of natural products rapidly, thus opening up exciting opportunities in new drug development for the pharmaceutical industry. - Focuses on the chemistry of bioactive natural products - Contains contributions by leading authorities in the field - Presents sources of new pharmacophores

New Look to Phytomedicine: Advancements in Herbal Products as Novel Drug Leads is a compilation of in-depth information on the phytopharmaceuticals used in modern medicine for the cure and management of difficult-to-treat and challenging diseases. Readers will find cutting-edge knowledge on the use of plant products with scientific validation, along with updates on advanced herbal medicine in pharmacokinetics and drug delivery. This authoritative book is a comprehensive collection of research based, scientific validations of bioactivities of plant products, such as anti-infective, anti-diabetic, anti-cancer, immune-modulatory and metabolic disorders presented by experts from across the globe. Step-by-step information is presented on chemistry, bioactivity and the functional aspects of biologically active compounds. In addition, the pharmacognosy of plant products with mechanistic descriptions of their actions, including pathogenicity is updated with information on the use of nanotechnology and molecular tools in relation to herbal drug research. - Compiles up-to-date information on the chemotherapeutics used in the treatment of infective and metabolic disorders - Presents advancements in the discovery of new drugs from plants using molecular and nanotechnology tools - Examines detailed information on the use of herbals agents in cancer, HIV and other ailments, including diabetes, malaria and neurological disorders

This book highlights the advances in essential oil research, from the plant physiology perspective to large-scale production, including bioanalytical methods and industrial applications. The book is divided into 4 sections. The first one is focused on essential oil composition and why plants produce these compounds that have been used by humans since ancient times. Part 2 presents an update on the use of essential oils in various areas, including food and pharma industries as well as agriculture. In part 3 readers will find new trends in bioanalytical methods. Lastly, part 4 presents a number of approaches to increase essential oil production, such as in vitro and hairy root culture, metabolic engineering and biotechnology. Altogether, this volume offers a comprehensive look at what researchers have been doing over the last years to better understand these compounds and how to explore them for the benefit of the society.

The Subcellular Biochemistry series has recently embarked upon an almost encyclopaedic coverage of topics relating to the structure and function of macromolecular complexes (Volumes 82, 83 and 87). The present multi-author text covers numerous aspects of current research into molecular virology, with emphasis upon viral protein and nucleoprotein structure and function. Structural data from cryo-electron microscopy and X-ray crystallography is displayed throughout the book. The 17 chapters in the book cover diverse interesting topics, all currently under investigation, contributed by authors who are active actively involved in present-day research. Whilst structural aspects predominate, there is much consideration of the structure-function relationship. In addition, the book correlates with and extends from Volume 68 of the series “Structure and Physics of Viruses: An Integrated Textbook”. This book is directed primarily at professionals that work in the broad field of Structural Biology and will be of particular interest to Structural Virologists. The editors, David Bhella and Robin Harris, have much experience in virology and protein structure, respectively. Dr Bhella is Director of the Scottish Macromolecular Imaging Centre. Professor Robin Harris is the long-standing Series Editor of the Subcellular Biochemistry series. He has edited and contributed to several books in the series.

Retrovirus-Cell Interactions provides an up-to-date review of the interactions between retroviruses and the cells they infect, offering a comprehensive understanding of how retroviruses hijack cellular factors to facilitate virus replication. Drugs targeting viral enzymes have been developed to treat HIV; the next challenge is to inhibit virus-cell interactions as next generation treatment strategies. Organized according to the retrovirus'replication cycle, this book does not focus exclusively on HIV, but rather includes important findings in other retroviral systems, including animal retroviruses, retrotransposons, and endogenous retroelements to allow broad comparisons on important commonalities and differences. - Provides a valuable starting point for people who want to develop a detailed understanding of retroviral replication - Includes future-thinking strategies, such as next-generation treatment and anti-retroviral therapeutics - Features important commonalities and differences among retroviral systems

This book reviews the current strategies and challenges for the treatment of bacterial, fungal, parasitic and viral infectious diseases in developing countries. Contributing authors present expert analysis on the transmission, epidemiology, bacteriology, pathogenesis and treatment of Neglected Tropical Bacterial Diseases such as Leprosy, Buruli ulcer, and Trachoma. Particular attention is also given to current antifungal agents, their spectrum of activity, mode of action, limitations, and current challenges in antifungal therapy. The authors explore the medicinal chemistry efforts that gave rise to currently launched drugs and new anti-HIV agents, and they also highlight the latest vaccine and drug developments in the clinical management of the Ebola Virus Disease, ignited by the 2014-2016 outbreak. This work has an interdisciplinary appeal and will engage scholars and professionals in the burden of communicable diseases.

Bakterien und Viren können krank machen – recht viel mehr haben sie aber nicht gemeinsam. Denn gegen Bakterien helfen Antibiotika – gegen die viel kleineren Viren ist jedoch kein Kraut gewachsen. Oder doch? Ein Blick in die Hausapotheke der Natur zeigt uns, dass es viele Phytotherapeutika gibt, also pflanzliche Arzneimittel, die sehr effektiv gegen die viralen Plagegeister helfen, die für zahlreiche Erkrankungen verantwortlich sind: Viren verursachen nicht nur Atemwegsinfekte oder Grippe, sondern auch Herpes, Warzen, Magen-Darm-Erkrankungen, Gürtelrose und Windpocken oder Pfeiffersches Drüsenfieber, um nur einige zu nennen. Die Biologin und erfahrene Sachbuchautorin erklärt, was Viren sind, welche Typen es gibt und warum Antibiotika bei ihrer Bekämpfung nichts bewirken können. Sie präsentiert eine ausführliche Liste diverser Pflanzen, Pilze und Gewürze, die sanft und nahezu nebenwirkungsfrei bei zahlreichen Erkrankungen eingesetzt werden können. Auch Kinder, die besonders häufig von viralen Infekten betroffen sind, profitieren von solch einer natürlichen Behandlungsweise. Ein umfangreiches Heilpflanzen-ABC zeigt ganz praktisch auf, welche Pflanzen in der Phytotherapie genutzt werden und wie sie sich zur Behandlung viraler Erkrankungen einsetzen lassen. Zahlreiche Rezepte, Dosierungshinweise und ein praktisches Register runden den anwenderfreundlichen und umfassenden Ratgeber ab.

Detailliert und praxisnah fasst dieses Buch das aktuelle Fachwissen zur Beratung der Patienten vor einer allgemein- oder viszeralchirurgischen Operation und zur postoperativen Betreuung durch den Hausarzt zusammen. Neben den gängigen Eingriffen sind auch invasive Maßnahmen zur Unterstützung der Therapie berücksichtigt, wie Gastrostomien, Ports, Schrittmacher, suprapubische Dauerkatheter und Urostomata. Indikationen und Operationsprinzip der einzelnen Verfahren sind ebenso dargestellt wie mögliche Komplikationen und ihre postoperative Behandlung. In Form von Fragen und Antworten werden häufige Fragen des Hausarztes an den Chirurgen, aber ebenso des Patienten an den Hausarzt präzise und bündig beantwortet. Hohe Praxisrelevanz der Beiträge ist durch die Zusammenarbeit von Allgemeinärzten mit Experten aus den operativen Fachgebieten sichergestellt.

Differential Diagnosis in Ultrasound Imaging, Second Edition, is a complete revision and extension of this best-selling Thieme title, bringing it up to date with the very latest clinical and technological standards. With a specific focus on general abdominal, genitourinary, and thyroid pathologies, it guides readers systematically through the process of sonographic differential diagnosis. The inclusion of images with variant courses and atypical sonographs ensures comprehensive coverage of this highly efficient diagnostic tool. Key features of the second edition: More than 1,100 new high-quality images, bringing the total number of illustrations to over 2,800 Draws upon the full spectrum of modern ultrasound modalities, including contrast-enhanced ultrasound (CEUS), Doppler, color Doppler, and elastography Navigational flow charts included in each chapter summarize possible diagnoses at a glance to ensure swift access to key information Clear layout with color-coded text boxes and tips, tricks, and pitfalls to help guide readers through the differential diagnosis process This new edition will be an essential reference for all residents and physicians using ultrasound on a day-to-day basis for diagnostic purposes, including practicing radiologists, internists, and ultrasound technicians.

Evidence-Based Validation of Herbal Medicines brings together current thinking and practice in the areas of characterization and validation of natural products. This book reviews all aspects of evaluation and development of medicines from plant sources, including their cultivation, collection, phytochemical and phyto-pharmacological evaluation, and therapeutic potential. Emphasis is placed on describing the full range of evidence-based analytical and bio-analytical techniques used to characterize natural products, including –omic technologies, phyto-chemical analysis, hyphenated techniques, and many more. - Includes state-of-the-art methods for detecting, isolating, and performing structure elucidation by degradation and spectroscopic techniques - Covers biosynthesis, synthesis, and biological activity related to natural products - Consolidates information to save time and money in research - Increases confidence levels in quality and validity of natural products

Healthcare professionals, including doctors, pharmacists and nurses, are often confronted with patients who use over-the-counter (OTC) herbal medicinal products and food supplements. While taking responsibility for one's own health and treatment options is encouraged, many patients use these products based on limited (and sometimes inaccurate) information from non-scientific sources, such as the popular press and internet. There is a clear need to offer balanced, well-informed advice to patients, yet a number of studies have shown that, generally, conventionally trained health practitioners consider their knowledge about herbal medicinal products and supplements to be weak. Phytopharmacy fills this knowledge gap, and is intended for use by the busy pharmacist, nurse, or doctor, as well as the ‘expert patient'and students of pharmacy and herbal medicine. It presents clear, practical and concise monographs on over a hundred popular herbal medicines and plant-based food supplements. Information provided in each monograph includes: • Indications• Summary and appraisal of clinical and pre-clinical evidence• Potential interactions• Contraindications• Possible adverse effectsAn overview of the current regulatory framework is also outlined, notably the EU Traditional Herbal Medicinal Products Directive. This stipulates that only licensed products or registered traditional herbal medicinal products (THRs), which have assured quality and safety, can now legally be sold OTC. Monographs are included of most of the major herbal ingredients found in THRs, and also some plant-basedfood supplements, which while not strictly medicines, may also have the potential to exert a physiological effect.

14. Gemeinsame Tagung der Deutschen, Österreichischen und Schweizer Gesellschaft für Ultraschall in der Medizin

Dieses Buch wendet sich an den viszeralchirurgisch tätigen Facharzt sowie den chirurgischen Assistenten. Dem Anfänger dient es als Lehrbuch, das ihn an die Ultraschalluntersuchung heranführt und in der Benutzung der Sonographie ausbildet. Der erfahrene Praktiker findet in dieser vollständigen Darstellung der viszeralchirurgischen Sonographie ein einzigartiges Nachschlagewerk, das einen umfassenden Überblick über die Möglichkeiten der Ultraschalldiagnostik und der ultraschallgestützten Therapie in der Viszeralchirurgie vermittelt. Besonderer Wert wird dabei auf Benutzerfreundlichkeit und Übersichtlichkeit gelegt: eine klare, einheitliche Strukturierung der einzelnen Kapitel zeichnet dieses Buch ebenso aus wie die didaktisch optimale Aufbereitung des Stoffes. Zur besseren Verdeutlichung der Lehrinhalte wird jeder sonographischen Originalabbildung eine elektronisch bearbeitete Version gegenübergestellt.

The nonsurgical management of gallstone disease has drawn widespread clinical interest during the last decade as ultrasound surveys have indicated that cholelithiasis is predom­ inantly an asymptomatic condition and much more prevalent than previously thought. This book presents an overview of the pathophysiologic and pathobiochemical principles of gallstone formation and the consequences for clinical therapeutic regimens. New information concerning the balance between vesicular and micellar transport of choles­ terol, early cholesterol nucleation, and the influence of inhibiting and promoting com­ pounds for cholesterol nucleation as well as information concerning the effects of changes in gallbladder motility and gallbladder mucosal function is reviewed. In order to make further progress in developing treatments which facilitate gallstone dissolution and in preventing disease, it is necessary to integrate this new data into our thinking. Methods of treatment such as systemic litholysis of cholesterol gallbladder stones with bile acid preparations and mechanical fragmentation of stones either by extracorpo­ ral shock waves or intracorporal laser systems are carefully described and separate discussions of direct contact litholysis of cholesterol stones with ether preparations and the local litholytic treatment of calcified pigment stones are included. New therapeutic applications of HMG-CoA-reductase inhibitors and nonsteroidal anti-inflammatory drugs are also critically reviewed. Finally, for the interested reader an evaluation of prophylactic treatment against stone recurrence after successful conservative treatment and an appraisal of alternative management strategies supplement the information on the conservative treatment of gallstones.

Gastroenterology is one of the branches of medicine that can profit most from modem technology, whether this involves the advances in diagnostic instrumentation, in data and image processing and management, or in computer applications like expert systems. To evaluate current status of imaging, computerization, and expert systems in gastroenterology, a group of clinical researchers and computer experts met in Bologna, Italy, for several days'discussion. The presentations at this symposium are introduced in this volume, which we believe to be a useful contribution to a specialization of great importance for health care as a whole. Bologna, March 1991 P. R. DAL MONTE Contents Imaging in Gastroenterology A. TORSOLI.......... 1 Experience with a Hospital-Wide Image Management and Communication System: Is Total Digital Radiology Possible? S.K. MUN (With 1 Figure)... 3 New Approaches to Endoscopy with the Electronic Videoendoscope M. SCHAPIRO.............. 15 Intraoperative Videocholangioscopy A. MONTORI, L. MASONI, and L. DE ANNA 19 Images and Communication F. VICARI........... 22 Didactic Potential of Videoendoscopy F. COSENTINO, E. MORANDI, G. RUBIS PASSONI, F. DI PRISCO, and S. TUCCIMEI........................... 24 Interactivity Between Image Processing Systems and Videoendoscopy M.A. PISTOIA, S. GUADAGNI, L. LOMBARDI, F. PISTOIA, M. CATARCI, and I. CARBONI............ 27 Endoscopic Laser Therapy of Colorectal Tumors 30 P. SPINELLI, M. DAL FANTE, and E. MERONI...

Infolge der Revolutionskriege stand das linke Rheinufer seit 1794 unter französischer Verwaltung und war seit 1801 Bestandteil des französischen Staatsterritoriums. Dieses neue Grenzgebiet musste in das napoleonische Émpire integriert werden. Ein Gegenstand politischen Handelns waren dabei die regionalen Eliten. Im Zentrum der Arbeit stehen die evangelischen Pfarrer im Roerdepartement. Auf breiter archivischer Quellenbasis untersucht Andreas Becker die Einbindung der als Funktionselite begriffenen Geistlichen durch Institutionen, Gesetzgebung und personelle Verflechtung. Er kann zeigen, dass die von der Forschung gerne angeführte vermeintliche »Indienstnahme« keineswegs ein einseitiger Prozess war, dessen Ergebnis bereits im Vorhinein feststand.

The sure way to accurate ultrasound diagnosis:With more than 2,000 illustrations, this one-of-a-kind book offers an entirely new system for using ultrasound imaging to achieve the correct diagnosis quickly and reliably. Covering the full spectrum of normal and pathologic findings in the human body, the authors -- all experts in the field -- present a color-coded system of more than 250 drop-down menus, which lay out all possible diagnoses at a glance and then guide the user swiftly and surely to an accurate diagnosis.The book's clear layout, flow charts, and text boxes make it possible to approach a diagnosis via different pathways, such as sonographic criteria, or with the most likely diagnosis. The detailed information -- plus all of the images -- required for the correct diagnosis are always at your fingertips. Organized anatomically, chapters each begin with a handy review of important sonographic characteristics and normal findings. The essential information for each possible abnormal finding follows, along with concise discussions of supplemental techniques, such as B-Mode images, Doppler imaging, and the use of contrast media.Elegantly crafted, concise, and accessible, Differential Diagnosis in Ultrasound is a tried and tested method for making the most of ultrasound as a highly efficient diagnostic tool.

Dieser Titel aus dem De Gruyter-Verlagsarchiv ist digitalisiert worden, um ihn der wissenschaftlichen Forschung zugänglich zu machen. Da der Titel erstmals im Nationalsozialismus publiziert wurde, ist er in besonderem Maße in seinem historischen Kontext zu betrachten. Mehr erfahren Sie hier.