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This book contains four selected chapters on pyrimidines and their importance. The first chapter examines the synthesis, physico-chemical properties, and anti-fungal activity of new hybrids of thiazolo[4,5-D] pyrimidines with (1H-1,2, 4) triazole. The second chapter reviews pyrimidine ring containing natural products and their biological importance. The third chapter examines the regulation of the pyrimidine biosynthetic pathway in the bacterium Pseudomonas chlororaphis. The fourth and final chapter looks at pyrimidines as potential corrosion inhibitors.

The purpose of this easy-to-use handbook is to provide a quick, accessible reference to nucleobase complexes. It describes these complexes with reference to methods of preparation, their characterization, and their toxicity and therapeutic indices. It lists the modes of coordination together with the relevant spectral data and major methods of investigation. This concise resource guide also includes data on the uncomplexed bases, such as solubility, pk, accepted structures in the solid state and solutions, and the natural occurrence of the base. Investigators in the fields of transition metal chemistry, biological inorganic chemistry and those working in medical laboratories will find this handbook indispensable.

Introduction Chapter 1 - Pyrimidinediones Chapter 2 - Primidone Chapter 3 - Pyrimidones Chapter 4 - Barbiturates Chapter 5 - Phenobarbital and Zidovudine Chapter 6 - Gemcitabine, Zalcitabine and Raltegravir

Chapter 1 - Pyrimidinediones Chapter 2 - Primidone Chapter 3 - Pyrimidones Chapter 4 - Barbiturates Chapter 5 - Pyrrolidinophenones Chapter 6 - Pyrrolidones Chapter 7 - Succinimide Chapter 8 - Lincosamides Chapter 9 - Nicotine

th This volume contains articles presented at the X International Symposium on Purines and Pyrimidines in Man, held on May 14 19, 2000 in Tel Aviv, Israel. The first symposium in this series took place in Tel Aviv in 1973. Since then, the symposium has been held every three years in different parts of the world, including Europe, USA and Japan. The participants, in this series of symposia, are characterised by a wide interest in the various aspects of purines and pyrimidines in man, which include biochemistry, genetics, pharmacology, physiology, clinics, etc. Presentations in the symposia include clarification of metabolic pathways, characterisation of enzyme structure and kinetics and discoveries of new inborn errors of metabolism and suggestions for new therapeutic approaches for these inborn errors. In addition, development of new purine and pyrimidine derivatives for the treatment of cancer and viral diseases, and many more subjects of mutual interest were brought to the fore. With the development of therapeutic means and of new research tools, we have witnessed changes in the areas of interest. The interest in gout and uric acid urolithiasis has lessened, whereas molecular aspects, the role of purine and pyrimidine substances in neurotransmission and in purinergic signaling appear to gain greater interest. The articles, included in this volume, contain new data pertaining to the various aspects detailed above.

The Chemistry of Heterocyclic Compounds, since its inception, has been recognized as a cornerstone of heterocyclic chemistry. Each volume attempts to discuss all aspects – properties, synthesis, reactions, physiological and industrial significance – of a specific ring system. To keep the series up-to-date, supplementary volumes covering the recent literature on each individual ring system have been published. Many ring systems (such as pyridines and oxazoles) are treated in distinct books, each consisting of separate volumes or parts dealing with different individual topics. With all authors are recognized authorities, the Chemistry of Heterocyclic Chemistry is considered worldwide as the indispensable resource for organic, bioorganic, and medicinal chemists.

The Chemistry of Heterocyclic Compounds, since its inception, has been recognized as a cornerstone of heterocyclic chemistry. Each volume attempts to discuss all aspects – properties, synthesis, reactions, physiological and industrial significance – of a specific ring system. To keep the series up-to-date, supplementary volumes covering the recent literature on each individual ring system have been published. Many ring systems (such as pyridines and oxazoles) are treated in distinct books, each consisting of separate volumes or parts dealing with different individual topics. With all authors are recognized authorities, the Chemistry of Heterocyclic Chemistry is considered worldwide as the indispensable resource for organic, bioorganic, and medicinal chemists.

The Novartis Foundation Series is a popular collection of the proceedings from Novartis Foundation Symposia, in which groups of leading scientists from a range of topics across biology, chemistry and medicine assembled to present papers and discuss results. The Novartis Foundation, originally known as the Ciba Foundation, is well known to scientists and clinicians around the world.