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This book highlights a comprehensive review of synthesis, properties, and strategies to improve the applicability of 2D materials like graphene, borophenes, metal nanosheets, phosphorene, and transition metal dichalcogenides (TMDs). It also highlights the synthesis of 2D-based hybrid composite materials and their effects on applicability, especially in energy, environment, and biomedical applications, by incorporating surface functional groups, metal/non-metal ions, and polymers. The advancement in innovative technology and use of 2D-based hybrid composite materials can improve the development of newer products/opening newer possibilities to fight existing issues related to environment, energy, and biomedical sciences. However, researchers continue to face numerous challenges in developing newer products/possibilities, large-scale production, with health and environmental impact being a challenge.This book serves as a valuable resource for researchers, professionals and students working in the field of advanced materials, especially 2D-based hybrid composites.

Pediatrics is an evolving field of medicine and with many new advancements in knowledge, scientific research, and technology in recent years. This concise and comprehensive 2nd Edition of the textbook'Update in Pediatrics'provides an update and overview of the latest advances and current literature in Pediatrics, assisting health professionals to review cutting-edge information in the different subspecialties in Pediatrics. This book is structured into chapters based on the various subspecialties in Pediatrics, and includes chapters ranging from traditional disciplines such as Infectious Disease and Cardiology, to more current disciplines such as Adolescent Medicine and Child Maltreatment. The team of authors is made up of experienced and expert clinicians and researchers in their respective fields. The target audience for this book includes any practitioner who cares for children, including pediatricians, family doctors, nurses and nurse practitioners, allied health professionals, residents, medical students, and health researchers providing an indispensable resource for the busy clinician and learner who wishes to stay up-to-date with the latest advances and knowledge in the field.

Hepatobiliary cancers, including hepatocellular carcinoma and biliary tract cancers, have high rate of mortality and low survival rate. The third volume of the “Interdisciplinary Cancer Research” series, entitled “Hepatobiliary Cancers: An Interdisciplinary Approach” publishes comprehensive volumes on mechanisms of hepatobiliary cancers and therapeutic modalities and presents the most updated and peer-reviewed chapters on hepatobiliary cancers. This interdisciplinary series is of special value to researchers working on cell biology, immunology, biochemistry, genetics, and practitioners working on oncology and gastroenterology. This is the main concept of Cancer Immunology Project (CIP), which is a part of Universal Scientific Education and Research Network (USERN). This interdisciplinary book will be of special value for researchers, oncologists, and gastroenterologists who wish to extend their knowledge on hepatobiliary cancers.

This book renders a comprehensive understanding of hematopoietic stem cells (HSCs) from their embryonic development through adult maintenance to aging, in the studies conducted in zebrafish and mammals. Hematopoiesis provides a paradigm for understanding the development, maintenance, regeneration, aging and malignant transformation of mammalian organs. Sitting at the apex of the hematopoiesis hierarchy tree, HSCs orchestrate their proliferation, self-renewal, and differentiation to produce all the blood cell lineages throughout life, which represents the best example for somatic stem cell studies. In this book, key regulatory mechanisms for HSC self-renewal and differentiation are overviewed in an array of fields including epigenetics, metabolism and microenvironment regulation. It also highlights the HSC heterogeneity and clonal dynamics from the recent advanced single-cell technologies. This book elaborates on the research history of HSC studies and reveals how the insights from HSC studies shed light on their clinic application. It presents great value from the bench to the clinic.

GASTROINTESTINAL ONCOLOGY Blends quality research findings with advanced educational techniques in a uniquely comprehensive approach Written and edited by leading international experts in the field, Gastrointestinal Oncology: A Critical Multidisciplinary Team Approach is an indispensable reference for clinicians, medical practitioners, and trainees involved in the investigation, diagnosis, and treatment of esophageal, gastric, intestinal, colonic, hepatobiliary, pancreatic, and other gastrointestinal tumors. Drawing on the most current evidence-based knowledge, this comprehensive resource reflects the current care of GI cancer patients, enabling effective clinical decision making and patient management. Setting the standard in clinical practice, Gastrointestinal Oncology remains the only truly multidisciplinary reference designed for the diverse team of clinicians responsible for different stages of cancer treatment. Specially structured clinical chapters, each representing a different role in the multidisciplinary team (MDT), allow clear presentation and quick reference of the contents. This is supported by a wealth of high-quality color photographs, line drawings, and diagrams. Now in its second edition, this authoritative reference is fully updated to reflect groundbreaking research in multiple medical fields, including the explorative use of A.I. New sections on palliative care and nutrition are accompanied by new sub-sections on molecular characterization, new targeted small molecule, receptor options, and immunological therapies for each cancer. This edition places renewed emphasis on the most ubiquitous conditions, such as colon cancer, liver cancer, and gastro-esophageal cancer. Covering the oncology of the entire gastrointestinal tract, Gastrointestinal Oncology: A Critical Multidisciplinary Team Approach is a must-have reference for the entire MDT, including gastroenterologists, hepatologists, GI surgeons, medical oncologists, radiation therapists, interventional radiologists, pathologists, nutritionists, palliative care and specialist nurses, as well as clinical scientists.

The Role of the Clinical Nurse Specialist in Cancer Care Gain a fresh and insightful perspective on the evolving role of the Clinical Nurse Specialist in the delivery of cancer services. The Role of the Clinical Nurse Specialist in Cancer Care explores the dynamic and essential world of the Clinical Nurse Specialist (CNS) in cancer care, covering both foundational and advanced topics and rooted in robust research and evidence-based practice. Trace the historical development of the CNS role while gaining invaluable patient and carer perspectives that provide essential guidance for professionals in this field Examine key aspects such as symptom management and non-medical prescribing, gaining a deeper understanding of the multifaceted responsibilities of Clinical Nurse Specialists Find vital subjects like leadership and multidisciplinary teamwork supplemented with practical tools to excel in your role Explore comprehensive coverage of specialised areas within clinical nursing, including the unique challenges of caring for young adults with cancer, navigating the complexities of COVID-19, and utilising digital tools for enhanced patient care Whether you are a registered nurse aspiring to become a clinical nurse specialist or an established CNS seeking professional growth, The Role of the Clinical Nurse Specialist in Cancer Care provides invaluable insights and development opportunities. This engaging resource is also an excellent companion for advanced practitioners specialising in cancer care, ensuring they stay up-to-date with the latest advancements in this vital field.

Precision Medicine and Human Health covers several aspects of precision medicine in 20 edited reviews by researchers and healthcare professionals. The breadth of information provided by the contributors aims to familiarize readers with basic and applied research in personalized therapy.Starting with an overview of the subject and its relationship with epigenetics, the book progresses into advanced topics that explain its wider applications. The use of precision medicine in treating different diseases such as protein misfolding disorders, gut ulcers and their effect on the gut microbiome, cancer treatment (for hepatocellular carcinoma, breast cancer, and oral cancer), fibromyalgia, high altitude sickness, and multiple sclerosis is explained. The book also covers modern therapeutic techniques to administer personalized therapy, including epithelial-mesenchymal therapy (EMT), circadian clock modulation, and artificial intelligence and phytoconstituents. The next chapters cover advanced technologies that are crucial to precision medicine, such as nanomaterials and advanced drug delivery systems. A concluding chapter on the therapeutic use of tannins in precision medicine rounds up the contents.Key Features:- Features 20 focused chapters contributed by scientific experts- Introduces readers to basic concepts in precision medicine- Covers the application of precision medicine in treating different diseases- Showcases several techniques used in experimental and clinical precision therapy- Explains modern technologies in precision medicine- Caters to a wide readership with introductions, structured headings, and referencesThis is an informative reference for healthcare professionals in clinics and hospitals and any scholar who wants to learn about basic and applied knowledge in precision medicine.

The Tata Memorial Centre Textbook of Oncology is an authoritative and comprehensive book, meticulously compiled to cover contemporary issues in oncology. It features contributions from 189 authors, culminating in 76 chapters. Authored by faculty members from the renowned Tata Memorial Centre, this textbook offers a harmonious blend of detailed information and practical approaches. It serves as a comprehensive resource that contextualizes the practice of oncology in TMC and offers insights into delivering high-quality cancer care in diverse settings. It offers an authentic overview of the TMC approach to multidisciplinary cancer care. The Textbook is designed to cater to a wide array of readers – from undergraduate medical students to postgraduates specializing in general surgery, general medicine, pediatrics, gynecology, radiation oncology, and other disciplines, and practicing community oncologists. A notable feature of the Textbook is its utility in preparing students for entrance and exit examinations. This book is an essential resource for established cancer specialists, including surgeons, medical oncologists, radiation oncologists, and those in allied fields. It is also invaluable for super-specialty students and postgraduates with an interest in cancer management, offering a comprehensive guide to the dynamic field of oncology.

Metabolic Fatty Liver Disease: Current Knowledge, Therapeutic Treatments, and Future Directions provides the most updated research findings and defines the current data gaps on metabolic fatty liver disease. The book extensively covers key areas in metabolic fatty liver disease research, including epidemiology (adults and children), economic burden, patient-reported outcome burden, natural history, current treatments, current diagnostic methods, controversies (NAFLD/MAFLD), current guidelines, fatty liver disease in the presence of other liver diseases as well as guidance on future research. This book will provide translational researchers with a current and comprehensive resource dedicated to all aspects of research in metabolic fatty liver disease, identify current gaps in research and make future research recommendations. It also offers clinicians a look at important background information in metabolic fatty liver disease and thoroughly reviews the latest research in this area to inform treatment outcomes. Compiles the latest, up-to-date science from key experts in the field on metabolic fatty liver diseaseReviews best practices and current guidelines for a comprehensive overviewIdentifies recommendations for future research endeavors

This book is focused on the history of cancer research. It follows the evolution of techniques and their applications in the diagnosis, treatment and management of cancer, from genetics to omics and finally the discovery of biomarkers. The book also discusses the present scenario in cancer development and management, and describes the importance of understanding cancer biology using microRNA, novel sequencing, and machine-learning approaches to determine DNA mutations. The book will be of value to students, research scholars, scientists, and innovators.

In diesem Band berichten die Autoren aus führenden Labors, die sich mit Stammzelltheranostik beschäftigen, über die neuesten Fortschritte auf dem Gebiet der Stammzellforschung. Das Buch befasst sich mit vielen Aspekten der stammzellbasierten Therapie und den Fortschritten in der Stammzelltherapie bei Leber-, Augen- und Herz-Kreislauf-Erkrankungen sowie bei Krebs. Dieser Band ist eine Fortsetzung der von Prof. Khawaja Husnain Haider bereits herausgegebenen Bücher zur stammzellbasierten Therapienostik. Es ist ein ideales Buch für Forscher, die sich mit der Entwicklung von Arzneimitteln sowie mit regenerativer Medizin und stammzellbasierter Therapie beschäftigen. Die sekundäre Zielgruppe umfasst Medizinstudenten, Ärzte, Zellpharmakologen, die Arzneimittelindustrie und Forscher, die Stammzellen als Ex-vivo-Krankheitsmodelle für die Arzneimittelentwicklung verwenden.

The COVID-19 pandemic caused by the SARS-CoV-2 virus has affected nearly every country and territory in the world. Although worldwide vaccination efforts have reduced the risk of serious disease outcomes, disparities in distribution have led to multiple waves of SARS-CoV-2 outbreaks and the emergence of variants of concern, some of which have enhanced infectivity and ability to evade existing vaccines. Hence there is an increasing interest in understanding the evolution of viruses like SARS-CoV-2, as well as improving our capacity to effectively current and manage future pandemics.This new volume reviews the most effective omic techniques for increasing our understanding of COVID-19, to improve diagnostics, prognostics, and genomic surveillance, and to facilitate development of effective treatments and vaccines. Chapters are written by an international team of experts and explore methods in the areas of genomics, transcriptomics, proteomics, and metabolomics. Techniques used toassess physiological function at the molecular level and artificial intelligence approaches used for more effective validation and translation of biomarker candidates into clinical use are also discussed. This book is an excellent resource for researchers studying biomarkers, virology, metabolic diseases, and infectious diseases, as well as clinical scientists, physicians, drug company scientists, and healthcare workers.

Small Animal Soft Tissue Surgery Provides a fully updated new edition of this comprehensive, detailed reference to surgical syndromes and diseases in small animals Small Animal Soft Tissue Surgery, Second Edition offers a thoroughly revised new edition of this comprehensive, detailed reference to surgical syndromes and diseases in small animal patients. Featuring detailed surgical descriptions accompanied by high-quality illustrations, the book updates the procedures throughout to include new and revised techniques. New chapters cover pyloric hypertrophy, coagulation factors and anticoagulation strategies, and pacemakers, with a newly standalone chapter on persistent aortic arches. Organized by body system, each section of the book includes a brief review of surgical anatomy and physiology. Chapters present surgical techniques, with information on pathophysiology, diagnosis, treatment, and prognosis, and a companion website provides video clips and slideshows demonstrating the procedures. The Second Edition: Presents a complete resource to small animal soft tissue surgery Features detailed surgical descriptions accompanied by high-quality illustrations Updates surgical techniques throughout to reflect new or refined procedures Adds chapters on pyloric hypertrophy, coagulation factors and anticoagulation strategies, and pacemakers, and splits persistent aortic arches into an expanded standalone chapter Features video clips and slideshows on a companion website to demonstrate the techniques covered Relying on the very latest literature to present the current state of the art, Small Animal Soft Tissue Surgery is an essential reference for small animal surgeons, residents, and practitioners performing soft tissue surgery.

Angiotensin: From the Kidney to Coronavirus, a new volume in the Molecular Mediators in Health and Disease series, presents the communication role of the hormone in both health and disease states. Beyond the most common conditions, the book also explores the role of Angiotensin in infectious diseases, like COVID-19. Sections provide background to its discovery and role in homeostasis, focus on molecular biology aspects, including genetics and measurements of its associated proteins, describe the specific actions of angiotensin in normal physiology with different organ systems, survey different classes of drugs that act on the Renin-angiotensin-aldosterone system, cover non-angiotensin II peptides, and more. The final part of the book is dedicated to angiotensin's role in disease states, making this the ideal reference for researchers in life sciences interested in understanding the physiological role of Angiotensin in a complete fashion. Research physicians will also benefit from the book's complete coverage of organ systems and diseases where Angiotensin plays a key role. Covers the traditional disorders related to Angiotensin and new findings like its role in infectious diseases like COVID-19 Offers an overview of all important aspects of angiotensin, from discovery to clinical application, from physical and chemical properties to the physiological/cellular interaction Expands on the role of angiotensin beyond the individual system the researcher is focusing, providing a comprehensive coverage of the additional effects at cell, tissue, organ, and system levels

The Comprehensive Guide to Hepatitis Advances provides the most up-to-date information on all types of hepatitis in one resource. Coverage spans hepatitis in all forms (viral, alcoholic, metabolic, drug, autoimmune, etc.), showing the implications of current research in clinical practice and discussing future research directions. Discussions focus on the scientific advancements in understanding the disease process and in the treatment of different groups of hepatitis.This reference is perfect for basic science researchers in the field of hepatology; practicing gastroenterologists and hepatologists as well as primary care physicians attending to liver disease; and medical residents undergoing specialist training in gastroenterology and hepatology. Provides comprehensive coverage of the different types of hepatitis Highlights the most recent research findings related to different types of hepatitis and their impact on clinical care Discusses future development specific to different types of hepatitis

This textbook describes several diseases and clinical conditions, from physiopathological mechanisms to main clinical pictures, highlighting the importance of laboratory medicine, with the aim to provide the necessary tools for guiding correct laboratory findings interpretation. Indeed, it is now widely recognized that laboratory medicine has a pivotal role in clinical medicine, significantly influencing clinical decisions. Thus, it is crucial to understand and use laboratory data appropriately. This book has the great advantage of describing each topic exhaustively in order to facilitate its understanding. Specifically, it describes both diseases with a high incidence in the population, such as Diabetes Mellitus, Cardiovascular Diseases, Dyslipidemias, and Autoimmune Diseases, as well as rare diseases, such as Hereditary Metabolic Diseases. In addition, unusual topics are treated, such as Clinical Biochemistry of the Mind, as well as hot topics, such as Biological Drugs, Biobanks, Health Technology Assessment, and Omics Sciences. Finally, the book includes a chapter on the new health emergency, the SARS-CoV-2 pandemic. Two appendices are provided at the end of the book: a table summarizing the reference range and decisional cut-off for the main laboratory parameters and instructions on performing a venous blood sample. The book will be an invaluable tool for medical and biomedical students, as well as for practitioners.

This book provides comprehensive information and clarity on all aspects of diagnosing and managing constrictive pericarditis. The operative procedures for constrictive pericarditis are presented in detail with technical tips supplemented by surgical videos. Further, it explores and guides on issues with mixed opinions like the role of corticosteroids, timing of the operation, choice of the operative procedure, terminologies to describe the extent of decortication, and the requirement of cardiopulmonary bypass. Despite experience spanning over 100 years, there is no fool-proof formula in the published literature that can be used in selecting an optimal surgical approach for a given patient. The terms'radical','total','extensive','complete','subtotal','adequate','near-total'and'partial'pericardiectomy also have been variably used in the literature, often without a precise definition of the limits of pericardial resection.Providing an update on the latest advancements and long-term results of pericardiectomy appeals to all clinicians managing constrictive pericarditis. For the trainees, it offers insights into surgical techniques'relevant anatomy and foundation. The book will be beneficial to MBBS, MD, MS, M.Ch (CTVS), DM (Cardiology), Diplomate of National Board (Cardiology and CTVS), FRCS, FRACS, MD (USA, Canada, and in all developing and developed countries).

The book covers all aspects of peri-operative anesthetic management of liver transplant patients. It provides a comprehensive coverage of the relevant history, surgeons', hepatologists', intensivists'and pediatricians'perspective of the disease, its pathogenesis, clinical presentation and indication for transplant. It discusses the practical aspects like fluid management and use of vasopressors. The book is divided into sections for a better and comprehensive delivery of information. Individual sections provide up to date information on the pre-operative issues and optimisation, intra-operative care and management and post-operative critical care issues and management of all transplant patients with special emphasis on recent advances. Separate sections cover ICU care of these patients in great detail and anesthetic management of pediatric liver transplant. The book includes anesthetic techniques involved in conducting multiorgan transplant. It discusses clinical approach toa patient with acute liver failure, brain death criteria and laws and organ donor management. It also presents newer techniques and methodologies adopted in the field of liver transplant. It includes ample illustrations, flowcharts, key points in each chapter, figures and photographs. The book contains chapters focusing on post-transplant patients presenting for non-transplant surgery. The book fills the gap in the literature for a comprehensive guide for the anesthetist performing or pursuing liver transplant, students/trainees/examinees who have a keen interest in this field and doctors dealing with such patients in critical care, donor management, pursuing general anesthesia. It is also helpful for hepatologists, intensivists and surgeons associated with liver transplant.

Cancer treatment is a challenging issue, while the treatment modalities have extended from traditional surgery, chemotherapy, and radiation therapy to new therapeutic approaches, including targeted therapy, immunotherapy, stem cell transplantation, and hormone therapy. Therefore, an interdisciplinary approach is needed to find a better therapeutic protocols in order to increase the prognosis and quality of life of patients with cancer. The second volume of the “Interdisciplinary Cancer Research” series, entitled “Cancer Treatment: An Interdisciplinary Approach” publishes comprehensive volumes on different cancer treatment modalities and presents the most updated and peer-reviewed articles on cancer therapy. This interdisciplinary series is of special value to researchers and practitioners working on cell biology, immunology, hematology, biochemistry, genetics, oncology and related fields. This is the main concept of Cancer Immunology Project (CIP), which is a part of Universal Scientific Education and Research Network (USERN). This interdisciplinary book will be of special value for researchers and clinicians who wish to extend their knowledge on cancer treatment.

This book is about the spleen, a mysterious organ, covering all aspects of its anatomy, physiology, and medical and surgical conditions affecting the spleen. It covers the most areas critical for decision making such as patient's presentation, diagnosis, and management. This book considers the recent developments in diagnosing and treating medical and surgical conditions affecting the spleen, including minimally invasive surgery. It is a quick reference book, well-illustrated, and easy to read and understand. This book should be helpful to medical consultants, surgeons, hematologists, and pediatric surgeons. It also benefits specialists, fellows, medical students, and nurses. The illustrations in this book are clear and include clinical, radiological, operative, pathological, and diagrammatic pictures. These illustrations are detailed, making them easy to grasp and understand.

Colorectal Cancer: Disease and Advanced Drug Delivery Strategies examines the combined impact of basic clinical and medical treatments as well as recent advances in the field of colorectal cancer.With a strong focus towards colorectal cancer diagnosis, disease drug delivery, and diagnosis, the book also examines the Tumor microenvironment-responsive and site-specific nanoparticles for cancer theragnostics.In 16 chapters Colorectal Cancer: Disease and Advanced Drug Delivery Strategies not only provides the opportunity to understand and diagnose the disease, but it also describes screening methods, drugs including nano- and immunotherapy, and gives insight into the role of nanoparticles, lipids, and biomarkers in colorectal cancer. Content includes clinical trials in colorectal cancer research and disease models. This book directs researchers and clinicians how to better diagnose and treat colorectal cancer.Provides a wealth of information on the latest research and developments in the science and treatment of colorectal cancerContains new and innovative ways to treat colorectal cancerReflects on basic clinical and medical methods and recent advances in colorectal cancer scienceGives specific details about how nanoparticles can be used to target cancer cells or cancer treatmentCovers tumor microenvironment, their challenges, and opportunities in colorectal cancer research

The successful book of andrology now in a new edition! This book gives a complete, interdisciplinary overview of the central topics of andrology, infertility, hypogonadism, contraception and erectile dysfunction. It contains detailed information on the clinical practice of couple treatment, andrology-relevant gynecology and modern methods of assisted fertilization, psychological factors of infertility, endocrinology and reproductive functions of the aging man as well as on an important sub-area of ​​andrology, the male contribution to contraception. In addition, the relevant scientific foundations (including molecular biology and genetics) are also covered. Completely revised and updated according to the latest scientific research, the new edition represents a reference for andrology, which no doctor who deals with the topic can miss. For andrologists, practitioners and residents, urologists, dermatologists and internists who deal with the area of​​andrology and male reproductive medicine.

Das Standardwerk der Andrologie - jetzt komplett aktualisiert! Das Buch gibt einen vollständigen, interdisziplinären Überblick aller Themen der Andrologie, u.a. · der Infertilität, · des Hypogonadismus, · der männlichen Kontrazeption, · der erektilen Dysfunktion und · der Varianten der sexuellen Differenzierung. Der Leser erhält detaillierte Informationen über · die Physiologie der Hoden- und Spermienfunktion · die Diagnostik und Therapie einschl. operativer Verfahren in der Andrologie · die klinische Praxis der Paarbehandlung, · relevante Fakten aus der Gynäkologie, · moderne Verfahren der assistierten Fertilisation · psychologische Faktoren der Sexualität und Infertilität · Umwelteinflüsse auf die Fertilität · Therapie mit Testosteron und Missbrauch · endokrinologische und reproduktive Funktionen des alternden Mannes. · Fertilitätsprotektion · rechtliche und ethische Grundlagen der Andrologie Zusätzlich werden die relevanten naturwissenschaftlichen Grundlagen – einschließlich Molekularbiologie und -genetik – abgedeckt. Komplett nach dem neuesten Stand der wissenschaftlichen Erkenntnis überarbeitet, aktualisiert und praxisorientiert ist der Nieschlag das Standardwerk der Andrologie, an dem keine Ärztin und kein Arzt, der sich mit dem Thema befasst, vorbeikommt. Für Andrologen und Teilnehmer der Zusatzbezeichnung'Andrologie', Urologen, Dermatologen und Internisten, die sich mit dem Gebiet Andrologie beschäftigen. Für Reproduktionsbiologen und Reproduktionsmediziner mit Interesse an der Paarbehandlung.

Sinusoidal Cells in Liver Diseases: Role in their Pathophysiology, Diagnosis, and Treatment provides a state-of-the-art review on recent advances surrounding the role of liver sinusoidal cells (LSECs, HSCs, macrophages, and other non-parenchymal cells) in acute and chronic liver diseases. Coverage emphasizes disease pathophysiology, novel mechanisms, unmet clinical questions, development of biomarkers and treatment opportunities. By focusing on the role of sinusoidal cells in human liver diseases, this reference provides a comprehensive overview of the role of sinusoidal cells in acute and chronic liver diseases, in its pathophysiology and mechanisms, and in the development of novel biomarkers and new therapeutics. Cells of the liver vasculature play an essential role in the pathophysiology of acute and chronic liver diseases and are considered key therapeutic targets to treat most of human hepatopathies. Coverage in this reference includes the phenotypic changes occurring in liver vascular cells and how cells contribute to the development of microcirculatory dysfunction, fibrosis, inflammation, and liver failure. Provides a comprehensive update on the role of sinusoidal cells in acute and chronic liver diseasesCovers our current understanding of the role of sinusoidal cells as therapeutic targets to improve liver diseasesPresents the latest research in the development of novel biomarkers of liver diseases that derive from sinusoidal cells

The book thoroughly presents Transarterial Chemoembolization (TACE), a procedure representing the standard of care for several clinical oncological indications.Thanks to the considerable technological advances in the available instrumentation (guidewire, microcatheter, guiding imaging modalities) as well as the different platforms utilized to perform treatment (conventional TACE, drug eluted TACE, degradable starch microsphere TACE) indication for treatment has been broadened and results significantly improved.By clearly depicting the procedure, with technical details, advantages and limitations, the book provides a unique and most updated source on TACE procedures. Clinical cases regarding crucial parts of the procedure are also provided.Expert users as well as novel clinicians interested in the most recent aspects of this interventional radiology procedure will find in this book a valuable tool and guide for their clinical routine.

Alcohol is one of the major risk factors for negative health outcomes worldwide. It accounts for more than 60 alcohol-related diseases, ranging from addiction, through liver cirrhosis, to cancer. Collectively, these conditions account for mortality and morbidity that make alcohol use one of the leading preventable causes of disability adjusted life-years (DALYs) lost globally. In this book, an international faculty covers all aspects of alcohol-related disorders, ranging from addiction/alcohol use disorders (AUD) to alcohol-related diseases of other organs such as liver, heart or cancer. A special focus is to reach out to primary care physicians who are in the front line of this major health problem. The book also provides an update for addiction specialists, as well as specialists in internal medicine, gastroenterology and hepatology. The book is divided into sections that include epidemiology, alcohol use disorders and addiction, alcohol-related liver disease, alcoholic hepatitis,primary care and interdisciplinary approaches and other alcohol-related diseases. Besides current diagnostic measures and treatment strategies, the book deals with the many underlying molecular and genetic mechanisms of alcohol toxicity. Novel insights include prospective data on all-cause mortality and the emerging major role of alcohol-mediated hemolysis and enhanced red blood cell turnover. The book also aims at guiding policy makers to handle the topic of alcohol in our society more responsibly.

Cardio-Hepatology: Connections Between Hepatic and Cardiovascular Disease provides a direct relationship between the cardiac and hepatic pathologies providing the link between the heart and liver and showing how liver diseases predispose to impairment in heart functioning and vice versa. Considering the growing number of patients living (and living longer) with heart failure and/or congenital heart disease, it is important to know when and how to test for liver disease in this population, how to interpret abnormal test results, and what management is appropriate. Coverage includes what should be done for patients to limit, avoid, or postpone the impairment in the liver functioning induced by heart diseases and the impairment in the heart functioning induced by liver diseases, on the basis of scientific-exposed evidence and pathophysiology knowledge. This comprehensive, extended review of the medical literature is perfect for researchers interested in the connection between cardiology and hepatology as well as clinicians making therapeutic decisions for patients suffering from heart or liver chronic diseases. Reviews and discusses all current knowledge about the interactions between heart and liver pathologies Provides guidance on current topics surrounding the assessment of the liver in heart failure Presents important clinical cardiovascular assessments in cirrhotic patients

'Remember, the critical questions in the field of Surgery never change, just the answers!'J. Bradley Aust M.D. 1926-2010 Acute Care Surgery and Trauma: Evidence-Based Practice discusses important surgical management approaches and clinical decision-making based on scientific evidence found in the published literature.Updated and fully revised, this new edition continues to support clinicians by providing the most up-to-date information and evidence on which to base their decisions across a wide range of topics in acute care surgery and trauma, thus optimizing the decision-making process for the care of individual patients. What can be better for the busy clinician than having all the answers to complex questions extensively researched by experts in the field and readily available without requiring further intensive literature searches? Featuring chapters written by specialists in acute care, trauma, and emergency surgery, with extensive references throughout. The text features tables summarizing key evidence and clinical recommendations for quick reference and easy interpretation. It provides an invaluable resource for all acute care surgery and trauma practitioners.'… should be in the library of every medical school, every department of surgery, and every surgeon.''A'must have'resource for every surgeon who manages trauma and acute care surgery patients…particularly useful for surgical residents and Surgical Critical Care and Trauma fellows, and attending surgeons.'

This book provides the latest research progress on Extracellular vesicles (EVs) in cardiovascular and metabolic diseases. EVs are small bilayer lipid membrane vesicles released by cells and function for intercellular communication. Increasing evidence has shown that EVs play crucial roles in cardiovascular and metabolic diseases, which seriously threaten human health worldwide. The book contains four sections: 1) Extraction Methods; 2) EVs in Cardiovascular Diseases; 3) EVs in Metabolic Diseases; and 4) Therapeutic Implications. This book is useful for biologists, cardiologists, cardiovascular surgeons, endocrinologists, internists, nurses, undergraduate and graduate students in medicine and cell biology, and others interested in cardiovascular and metabolic medicine.

The book is a compact yet comprehensive practical resource that highlights all must-know information on non-alcoholic fatty liver disease (NAFLD). Covering the major issues dominating the field, this book offers a broad vision on NAFLD using key data for a deep and thorough understanding of the latest diagnostic methods, treatment options, potential complications, and disease management strategies to improve patient outcomes. The volume bridges the trans-disciplinary divide between hepatologists, cardiologists, nephrologists, psychiatrists, oncologists and dermatologists in order to cover the complex management of NAFLD in a single volume. It operates under a modern definition of NAFLD that acknowledges the range of presentations related to extrahepatic complications that hepatologists see in daily practice, while also delving into unanswered questions and future directions regarding treatment options. Offering practical, clinical guidance in addition to capturing the new promising therapeutic approaches in the pipeline, this book is an essential reference for clinicians, researchers and students.

Balancing basic science with information on everyday clinical practice, Blumgart's Surgery of the Liver, Biliary Tract and Pancreas, 7th Edition, provides you with expert guidance and advances in the field so you can offer patients the most optimal diagnostic and surgical care. In two convenient volumes, Dr. William Jarnagin and his team of internationally recognized surgeons cover exactly what you need to know, including advances in diagnostic and surgical techniques, minimally invasive surgeries, new interventional diagnostic techniques, and all relevant diseases. This comprehensive, practical reference is designed to help you choose and perform the most appropriate procedures that will minimize inpatient hospital time, curtail costs, and reduce overall recovery time for your patients. Presents cutting-edge guidance on pathology, diagnostics, surgery and non-operative intervention of the liver, biliary tract, and pancreas in one highly regarded, authoritative reference. Covers all surgical approaches, both open and minimally invasive. Considers all worldwide opinions and approaches to management, and includes key data on surgical outcomes to better inform clinical decision-making. Contains 161 chapters with updated references and additional figures—more than 1,500 illustrations in all. The imaging section has been reorganized to reflect a disease-based approach. Includes new and expanded sections on advances in molecular characterization of benign and malignant HPB diseases, perioperative management, interventional techniques, minimally invasive surgery and robotics, and therapeutic advances for malignant disease. Features a section dedicated entirely to operative technique, plus a new historical chapter authored by Professor Jacques Belghitti: “Hepatobiliary and Pancreatic Surgery: Historical Perspective.”

In 2020 we lost Noel Rose, co-editor of the classic Infection and Autoimmunity. To honor and respect his work, a group of experts in the field have taken the initiative to make this book perpetual. The third edition of Infection and Autoimmunity updates all the recent and leading papers on infection and autoimmunity, in addition to a dedicated section on to the correlation between SARS-CoV-2 infection and autoimmunity. From the very beginning of the COVID-19 pandemic, numerous papers have been published, including studies conducted by the editors and authors of the book, on COVID-19 and autoimmunity, and therefore this knowledge has been incorporated into this new edition. The addition and extended coverage on SARS-CoV-2/COVID-19 and autoimmunity are pivotal for the third edition of the book due to the COVID-19 pandemic. Medical students and practitioners, as well as academic staff in medical schools globally, are enthusiastic in searching for better understanding of the correlation between infection and autoimmunity in general, and the long-term effects of SARS-CoV-2 and COVID-19 on the immunce system in particular, especially in terms of autoimmunity related to the virus. Fully revised and updated by a global group of experts, dedicated to and in honor of Noel Rose Includes 52 completely updated chapters with the latest developments in the field Is the only book directed specifically at the interactions between infectious agents and autoimmunity Describes the prevalence and incidence of global issues and current therapeutic approaches Addresses in full, details of the mechanisms behind the emergence of autoimmune diseases secondary to infections Brings the reader up-to-date and allows easy access to individual topics in one place

This book aims to provide an updated information on different types of major and emerging drugs for managing liver cirrhosis and its complications, including acute gastroesophageal variceal bleeding, ascites, hepatic encephalopathy, liver failure, acute kidney injury, and portal venous thrombosis. The chapters are organized by drug class, such as anti-HBV drugs, anti-HCV drugs, anticoagulants, and antibiotics, etc. The clinical efficacy, indication, and contra-indication of the various drug therapies are discussed using supportive reference material from authoritative sources and published clinical trials. It will be an invaluable reference for physicians who are treating patients with liver cirrhosis, especially those presenting with acute life-threatening complications.

Biologics and Biosimilars: Drug Discovery and Clinical Applications is a systematic integration and evaluation of all aspects of biologics and biosimilars, encompassing research and development, clinical use, global regulation, and more. Biosimilars are biological therapeutic agents designed to imitate a reference biologic with high similarities in structure, efficacy, and safety, but also with potential clinical effective and cost-efficient options for the manufacturers, payers, clinicians, and patients. Most of the top-selling prescription drugs in the current market are biologics, which have revolutionized the treatment strategies and modalities for life-threatening and/or rare diseases.This book outlines the key processes and challenges in drug development, regulations, and clinical applications of biologics, biosimilars, and even interchangeable biosimilars. Global experts in the field discuss essential categories and prototype drugs of biologics and biosimilars in clinical practice such as allergenics, blood and blood components, cell treatment, gene therapy, recombinant therapeutic proteins or peptides, tissues, and vaccines.Additional features: Integrates the latest bench and bedside evidence of drug development and regulations of biologics and biosimilars Contains key study questions for each chapter to guide the readers, as well as drug charts for all therapeutic applications of biologics and biosimilars Presents detailed schematic illustrations to explain the drug development, clinical trials, regulations, and clinical applications of biologics and biosimilars This book is an invaluable tool for health care professional students, providers, and pharmaceutical and health care industries, as well as the public, providing readers with educational updates about the drug development and clinical affairs of biological medications and their similar drugs.

Liver transplantations require a complex and varied, multidisciplinary approach involving not only hepatologists and surgeons but also pathologists, psychologists, professional educators, nurses and, in the case of young patients, also pediatricians and development experts. This textbook provides an overview of the management problems involved in liver transplantation for acute and chronic liver disease, pediatric liver transplantation and the psychosocial aspects of liver transplantation. A closing chapter, focusing on the developments and future prospects in liver transplantation, outlines the potential offered by donors after cardiac death, cell therapies and organogenesis. The multidisciplinary approach is also maintained in the selection of authors, all experts actively engaged in the various disciplines involved in liver transplantations. This aspect, together with its precise and didactic descriptions of all phases of liver transplantation for chronic and acute diseases – from managing waiting lists to post-transplant complications – make the book a valuable tool for fellows, trainees, and specialists in the field seeking accurate framework for liver transplantation in its many facets.

SCHALM'S VETERINARY HEMATOLOGY An updated guide to veterinary hematology with expanded coverage on a variety of topics The revised seventh edition of Schalm's Veterinary Hematology is updated to provide a comprehensive review of all topics related to disorders of the blood in animals. Designed as a gold-standard reference, this text covers a wide range of species in both confined and free-range populations, reflects the most recent trends in hematology diagnostics, and discusses recent advances in traditional techniques. Edited and written by an international team of experts in the field, the book represents an accessible yet in-depth resource for information on veterinary hematology. The new edition includes a hemolymphatic tissue section that covers current understanding of basic science and the species-specific hematology section is further expanded from previous editions. New chapters address emerging topics in hematology, and existing chapters have been revised and rearranged to improve readability and simplify access to the material. This seventh edition: Updates the most complete reference on veterinary hematology across species Contains a new section on basic biology of hemolymphatic tissues Expands coverage of species-specific hematology Presents new and emerging topics in blood disorders and diagnostic techniques Features a reorganized contents list for an integrated, easy to use reference Written for veterinary clinical pathologists and residents, diagnostic laboratory staff, internists, and specialists, Schalm's Veterinary Hematology is the most comprehensive and up-to-date reference on the topic.

This book explores the concept of prehabilitation to great depths using all possible modes of prehabilitation across surgical specialities. Prehabilitation is a unique concept that is becoming popular day-by-day. It began from the enhanced recovery after surgery (ERAS) program and has found importance in almost all of the surgeries now. The book possibly being the first on prehabilitation globally introduces the concept, describes the methods of functional assessment of the patients scheduled for extensive cancer surgery, and ways of pre-optimisation. It covers the methods of prehabilitation system-wise and then provides pehabilitation tools specific for individual onco-surgical subspecialties. The book will be an invaluable resource for practitioners of onco-anesthesia and onco-surgery in optimizing their patients before surgery for best results. It will also be useful for the allied disciplines such as nutritionists, physiotherapists, psychiatrists and oncology nurses.

This book focuses on a broad range of immunomodulators, including both natural and synthetic ones. It highlights their role in human health. The book discusses nanotechnology-based immunomodulators with special emphasis on different types of formulation to boost the immune system. It highlights the role of immunomodulators against different microbes. This book describes important topics such as Classification and uses of various immunomodulators; Potential role of herbs and spices on immune system; Immune booster activity of prebiotics; Recent advances of nutraceutical and functional foods in Immune health; Antioxidants and immunomodulation; Nanotechnology and immunomodulators in cancer; Immunomodulatory role for the treatment and management of tuberculosis; Immunomodulation in autoimmune disorders; Herbal immunomodulators and COVID-19; Role of Cytokines as Immunomodulators and Immunomodulatory effects of endocrine disrupting chemicals. This book covers various aspects of product innovation, development, and launching of nutritional and pharmaceutical products with reference to immunomodulators. This book is meant for researchers and students in the field of immunology and pharmaceutical sciences.

This book summarizes evidence on frailty and ageing, how this may impact patient outcomes and how frailty can be assessed, managed and incorporated in the decision-making process for older patients with cancer. The book aims to: empower clinical teams to assess and support older cancer patients with frailty, ideally within a multidisciplinary setting; and to improve the selection of older cancer patients to the most appropriate management/treatment strategies in order to improve the outcomes of this group of patients often underrepresented in research. The reader will learn the methods available for assessing frailty, such as screening tools, but also how to perform different geriatric assessments covering the different key components (physical, nutritional, social, psychological, etc.). The book also provides information on how to manage and intervene on frailty with the role of pre-habilitation and re-habilitation, how to set-up specialised teams and pathways within one's hospital and community for these older cancer patients with frailty. Finally, the management of this challenging group of patients according to the cancer type is discussed in detail, alongside with mapping the unmet research needs and future directions in this field.

A comprehensive guide to the current research, major challenges, and future prospects of controlled drug delivery systems Controlled drug delivery has the potential to significantly improve therapeutic outcomes, increase clinical benefits, and enhance the safety of drugs in a wide range of diseases and health conditions. Fundamentals of Drug Delivery provides comprehensive and up-to-date coverage of the essential principles and processes of modern controlled drug delivery systems. Featuring contributions by respected researchers, clinicians, and pharmaceutical industry professionals, this edited volume reviews the latest research in the field and addresses the many issues central to the development of effective, controlled drug delivery. Divided in three parts, the book begins by introducing the concept of drug delivery and discussing both challenges and opportunities within the rapidly evolving field. The second section presents an in-depth critique of the common administration routes for controlled drug delivery, including delivery through skin, the lungs, and via ocular, nasal, and otic routes. The concluding section summarizes the current state of the field and examines specific issues in drug delivery and advanced delivery technologies, such as the use of nanotechnology in dermal drug delivery and advanced drug delivery systems for biologics. This authoritative resource: Covers each main stage of the drug development process, including selecting pharmaceutical candidates and evaluating their physicochemical characteristics Describes the role and application of mathematical modelling and the influence of drug transporters in pharmacokinetics and drug disposition Details the physiology and barriers to drug delivery for each administration route Presents a historical perspective and a look into the possible future of advanced drug delivery systems Explores nanotechnology and cell-mediated drug delivery, including applications for targeted delivery and toxicological and safety issues Includes comprehensive references and links to the primary literature Edited by a team of of internationally-recognized experts, Fundamentals of Drug Delivery is essential reading for researchers, industrial scientists, and advanced students in all areas of drug delivery including pharmaceutics, pharmaceutical sciences, biomedical engineering, polymer and materials science, and chemical and biochemical engineering.

This book addresses and dissects the roles and crosstalk mechanisms for the 48 human nuclear receptors (NR) in human health and disease. After a State-of-the-Art introduction by an undisputed and celebrated field leader to provide an overview of the field and its significance, chapters are organized into six sections. The first three sections discuss NR roles in Reproduction & Development, Metabolism and Central Systems. These present to the reader our current understanding of NR signaling in the development and functioning of the reproductive system; the roles in the regulation of energy metabolism; and how NR signaling is more widely integrated into systemic functions from calcium flux to circadian rhythm. The subsequent three sections dissect how aberrant NR functions drive Cancer; how new insights into Genomic Interaction are helping to reveal how NR disruption drives disease; and finally, how Translational Efforts are exploiting this understanding from developing novel NR ligands to establishing how underlying genetic variation impacts NR function. Within these sections the chapters also illustrate emerging understanding of how the epigenome and non-coding genome combine to regulate NR function and impact dysfunction. Increasingly these insights cross-fertilize over cell and disease boundaries and it is unsurprising that NR are being explored in novel and new arenas such as the context of neurological disorders and depression. Thus, there is wide scope for re-purposing of licensed drugs and development of new NR-targeting therapies for a host of conditions and diseases. This unique book brings together many of the leading figures in NR research from across the globe, to discuss emerging roles and their implications for human health and disease. It summarizes the state of the art and shows signposts for future research to further shape this influential field.

This book, edited by leading experts in radiology, offers a state-of-the-art overview of the specifics and the added value of dual-energy, multi-energy, and spectral computed tomography (CT). Latest advances and upcoming innovations such as photon-counting detector CT are covered by renown experts in the field. The entire spectrum of clinical applications of dual-energy and spectral CT throughout the body is covered. Book chapters are written by expert authors with a background in physics and radiology and are richly illustrated with high quality figures, graphical illustrations, and tables. The first section covers background issues and the most relevant technical aspects of the technique, including a detailed description of the approaches to dual-energy, spectral and photon-counting CT by different vendors of CT scanners. The second part focusses on the use of dual-energy, spectral and photon-counting CT in daily clinical practice, and individual chapters are devoted to imaging of the brain, cardiovascular system, gastrointestinal tract, abdominal organs, skeletal system, and the chest. The focus of the book ensures that it will be of interest for a multidisciplinary forum of readers comprising radiologists, medical physicists, and other medical professionals and scientists being interested in cutting-edge CT imaging.

Hepatobiliary cancer refers to primary malignant tumors originating in cells of the liver, bile ducts, and gallbladder. Globally, primary liver cancer, which includes hepatocellular carcinoma (~75% of all cases) and intrahepatic biliary cancer or cholangiocarcinoma (~10-15% 0f all cases) is the 6th most commonly diagnosed cancer and 3rd leading cause of cancer deaths worldwide. The vast majority of these highly malignant cancers are diagnosed at an advanced stage where treatment options are limited and patient survival outcomes are poor. The biological and therapeutic challenges posed by hepatobililiary cancers such as hepatocellular carcinoma (HCC) and cholangiocarcinoma (CCA) are daunting, emphasizing a critical need to review and assess current and evolving basic, translational, and clinical research focused on addressing the critical obstacles that continue to limit progress towards achieving significant improvements in HCC and CCA clinical management and patient survival outcomes. Towards this goal, this special edition of Advances in Cancer Research is focused on providing a comprehensive, timely and authoritative reviews covering such topics of significant scientific and clinical relevance, including hepatobiliary cancer risk mechanisms and risk-predictive molecular biomarkers; causes and functional intricacies of inter- and intratumor heterogeneity; novel insights into the role of tumor microenvironment and key signaling pathways in promoting hepatobiliary cancer progression, therapeutic resistance and immunosuppression; emerging biomarkers of HCC and CCA prognosis; advances in molecular genomics for personalizing tumor classification and targeted therapies; innovative preclinical cell culture modeling for hepatobiliary cancer drug discovery; and current and emerging trends in hepatobiliary cancer molecular therapeutic targeting and immunotherapies. Up-to date review of hepatobiliary cancers molecular genetics, novel predictive molecular biomarkers, and distinct mechanisms of inter-and intratumor heterogeneity Novel insights into the role of tumor microenvironment as a promoter of hepatobiliary cancer progression and therapeutic resistance, as well as an emerging therapeutic target Current and emerging approaches and strategies for advancing personalized molecular therapeutic targeting and immunotherapy of hepatobiliary cancers

Nuclear Medicine and Molecular Imaging offers complete coverage of this exciting and key area of biomedicine, seamlessly fusing the science behind nuclear medicine with the clinical aspects of diagnostic imaging. Beginning with sections on the physics related to nuclear medicine, radiation biology/safety, and instrumentation/quality control, it then covers radiochemistry and the development of new radionuclide therapy/tracers, and basic techniques such as positron emission tomography (PET) and single photon emission computed tomography (SPECT). The focus then shifts to the clinical aspects, with sections on clinical/preclinical nuclear imaging (structured via organ system such as gastrointestinal, cardiovascular, pulmonary, etc.), as well as other in vivo molecular imaging techniques such as optical imaging, digital image analysis (radiomics), as well as the increasing use of artificial intelligence (AI) in diagnostics. No other publication provides such a complete overview of the field, with most choosing to focus either on physics or imaging. In most cases, preclinical/experimental imaging is treated separately from clinical imaging. Nuclear Medicine and Molecular Imaging brings it all together into a complete, 4-volume, foundational resource for researchers and medical professionals specializing in this exciting area. Provides a ‘one-stop'resource on all aspects of Nuclear Medicine and Molecular Imaging, including both preclinical and clinical aspects, physics and applications Presents concise, authoritative chapters expertly authored Includes high quality, full color images and videos, as well as interactive multimedia features

Comprehensive Pharmacology, Seven Volume Set is organized into twelve sections that explore therapeutic areas, with a total of 320 comprehensive articles and 6,800 pages of important findings. Sections contain highly detailed coverage of information that has been overseen by an editorial board made up of well-respected, field leading experts. The content in this book offers readers an in-depth and easily accessible reference work on every aspect of pharmacological research surrounding the pharmacology of all therapeutic applications of drugs, their mechanism of action and their therapeutic values. These elements are essential as drugs are almost never tested and developed in the actual therapeutic system, but rather in test systems from which parameters must be determined to predict activity in systems of varying ambient physiology. As different technologies rapidly evolve, there is an ever-increasing level of knowledge about the pharmacology of known drugs, along with increasing capability to utilize pharmacological systems to predict new drug activity, all of which must be communicated to professionals in varying fields. Contains chapters that follow a consistent and templated approach, resulting in well-structured content that enhances user experience and appeal Offers a comprehensive review on a wealth of information on pharmacology and how it utilizes concepts and techniques from a broad array of sciences, ranging from chemistry to physiology to medicine Includes a wider use of color and multimedia content, with interactive features, links, computational modeling and animations to illustrate the effects of toxic substances in various contexts

The Oxford Textbook of Global Public Health is the ultimate resource on the subject of public health and epidemiology. It offers a global and comprehensive perspective on wide-ranging public health needs and priorities in modern health care. Thoroughly revised and updated for the seventh edition, the book is split into three main topics.'The Scope of Public Health'covers the development of the discipline, determinants of health and disease, and policies, law, and ethics. The second volume focuses on The Methods of Public Health, including the science of epidemiology, social science techniques, and environmental techniques. Finally, The Practice of Public Health is fully explored, with sections on specific public health problems, ways of prevention and control, the varying needs of different populations, and the functions of public health services and professionals. Three new editors have joined for this edition, Liming Li (China), Fran Baum (Australia), and Alastair H Leyland (UK), complimenting Quarraisha Abdool Karim (South Africa) and Roger Detels (USA), for a truly global perspective on public health. Featuring over 225 contributors from countries all over the world ensures that the book covers public health from all aspects, with vastly different health systems and priorities. Featuring new chapters on gender identity and gender-based violence, environmental health and climate change, genomics and epidemiology, and emerging and re-emerging infectious diseases, the seventh edition of the Oxford Textbook of Global Public Health remains the most comprehensive text on the subject and is a vital resource for public health practitioners and trainees, clinical epidemiologists, and students in the field.

This expert volume in the Diagnostic Pathology series is an excellent point-of-care resource for practitioners at all levels of experience and training. Covering all areas of splenic pathology, it incorporates the most recent clinical, pathologic, and molecular knowledge in this challenging field to provide a comprehensive overview of all key issues relevant to today's practice. Richly illustrated and easy to use, the 2nd edition of Diagnostic Pathology: Spleen is a one-stop reference for accurate, complete pathology reports, ideal as a day-to-day reference or as a reliable training resource. Provides essential knowledge focused entirely on splenic pathology, including immunohistochemistry, flow cytometry, and molecular testing as they relate to splenic lesions and their differential diagnoses Presents up-to-date information on splenic injury and laceration grading and management, the findings of next-generation sequencing studies, and a range of molecularly defined genetic alterations of spleen neoplasms Features an Antibody Index and Molecular Factors Index to assist with identification and diagnosis Includes 14 new chapters covering topics such as autoimmune disease involving the spleen, spleen anatomy, splenic microcirculation, immune function of the spleen, spleen imaging, leukemic non-nodal mantle cell lymphoma, Tay-Sachs disease, normal T-cell subsets, and many others Includes approximately 2,000 high-quality clinical and histologic images, gross pathology images, radiologic images, and full-color illustrations to help practicing and in-training pathologists reach a confident diagnosis Includes updated criteria, terminology, and classifications from the 2017 World Health Organization Classification of Lymphoid Neoplasms Employs consistently templated chapters, bulleted content, key facts, and annotated images for quick, expert reference at the point of care

This book, the seventh in a series of proceedings volumes that began in 1995, reviews the latest developments in the diagnosis and management of cirrhosis and portal hypertension. It addresses a broad range of topics, including: risk stratification, HVPG, non-invasive surrogates for cACLD, CSPH, varices, progression and regression of cirrhosis, impact of etiological therapy on cirrhosis, impact of non-etiological novel therapies on cirrhosis, prevention of first/further decompensation, acute variceal hemorrhage, and Vascular Liver Disorders in Cirrhosis (VALDIG).The book is a compilation of lectures and important consensus statements from the Seventh Baveno International Consensus Workshop on Portal Hypertension, the latest in a series of workshops held every five years for hepatologists with an interest in the field. Portal Hypertension VII offers a valuable reference guide for clinical and research fellows in Gastroenterology and Hepatology and will inspire new research projects in the promising areas identified by the experts of the Baveno VII Faculty.

Over the last two decades, there have been major advances in imaging, endoscopy, and laparoscopy in the field of gastrointestinal (GI) surgery. GI surgery is the newest sub-specialty branch of general surgery, where enhanced expertise and high-volume centres have made a difference to the outcomes of complex operations. Surgeons can now perform difficult procedures with low morbidity and mortality rates, and greatly improved overall results. This volume provides detailed and up-to-date information on diseases of the mesentery, omentum, peritoneum, and retroperitoneum as well as abdominal trauma. As an area of surgery that may often be neglected in traditional teaching, with limited resources to aid clinical decision making, diseases and trauma in this area can lead to situations where even the most experienced surgeon may feel challenged. Managing patients with these diseases successfully warrants a comprehensive knowledge of their anatomy and physiology as well as the pathology involved. The book provides comprehensive coverage of the different conditions and traumas, and includes a final chapter covering abdominal surgery during the COVID-19 pandemic. Written and edited by international experts in the field, this book will be a valuable resource for abdominal, peritoneum and retroperitoneum surgeons and trainees, general surgeons, researchers, and medical students.