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This book comprises select peer-reviewed proceedings of the 9th International and 49th National Conference on Fluid Mechanics and Fluid Power (FMFP 2022). This book brings together scientific ideas and engineering solutions put forth by researchers and practitioners from academia and industry in the important and ubiquitous field of fluid mechanics. The contents of this book focus on fundamental issues and perspective in fluid mechanics, measurement techniques in fluid mechanics, computational fluid and gas dynamics, instability, transition and turbulence, fluid-structure interaction, multiphase flows, microfluidics, bio-inspired fluid mechanics, aerodynamics, turbomachinery, propulsion and power and other miscellaneous topics in the broad domain of fluid mechanics. This book is a useful reference to researchers and professionals working in the broad field of mechanics.

This book offers an overview of the biological basis of 26 different solid cancers for scientists and oncologists to understand the clinical challenges. The book provides a quick, simplified, and updated review of the present genetic or genomic medicine era. With genetic and molecular details to enhance understanding of biological mechanisms underlying disease pathogenesis and treatment response, each chapter covers epidemiology, risk factors, classification, pathophysiology, genetics, and treatment of solid cancers. This book is a beginner's guide for life sciences and medicine graduate students, fellows in training, biomedical sciences researchers, principal investigators, clinician-researchers and oncologists.

Schizophrenia Spectrum Disorders (SSD) manifest multidimensionally, presenting a syndromic nature with several symptomatic domains. These are driven by dynamic systemic biological changes that unfold over the course of the disease. Thus far, the diagnosis is solely based on symptoms, which may be rather subjective, moving research toward the search for SSD biomarkers. This book presents a summary of the main hypotheses that have evolved over time to explain the pathophysiology of SSD and that have driven the discovery of associated biomarkers: neurotrophic, neurotransmitter, neuroendocrine, immune-inflammatory, nitrosative/oxidative stress, metabolic, and gut microbiota-brain axis. The book shows the most relevant research carried out in the last twelve years to develop predictive, diagnostic, theranostic or transdiagnostic models based on these biomarkers using the receiver operating characteristic curve (ROC) analysis. Chapters also discuss how the literature has addressed the development and/or addition of new discriminatory biomarkers to achieve robust and successful results. The book is rounded out with a step-by-step explanation on how to work on the MetaboAnalyst platform, including the meaning of the chosen statistics and how to interpret them in the results obtained. This book is a useful resource for students and scientists involved in the discovery of biomarkers for psychiatric disorders and other diseases.

This book gathers the consensus recommendations on diagnostic procedures in patients with neck masses by the European Head and Neck Society, European Federation of Cytology Societies, European Society of Hybrid Imaging and International Melanoma Pathology Study Group. Because of the variability of anatomical structures and the richness of histological tissues, the diagnostic process for neck masses is often complex. The diagnostic process depends on the habits of oncological centers, the experience of specialists and particular standards. In reality, there is no international recommendations which would allow to define the optimal and least invasive modalities for carrying out a rapid and accurate diagnosis. Written by the most eminent specialists of different profiles and geographic areas, who present and analyze different technical modalities, the book combines the different points of view and defines the agreed upon optimal technique. Each chapter is short, informative, well referenced and the main messages are placed in tables and boxes. The book is addressed to oncologists, radiologists, nuclear physicians, ENT surgeons, surgical- and cyto-pathologists. This work is under the patronage of the International Academy of Cytoloy (IAC).

This book is a collection of high-quality peer-reviewed research papers presented at International Conference on Recent Trends in Computing (ICRTC 2023) held at SRM Institute of Science and Technology, Ghaziabad, Delhi, India, during June 2–3, 2023. The book discusses a wide variety of industrial, engineering, and scientific applications of the emerging techniques. The book presents original works from researchers from academic and industry in the field of networking, security, big data, and the Internet of things.

Substance Use and Addiction Research: Methodology, Mechanisms, and Therapeutics is an up-to-date, comprehensive, practical book on research methodologies for substance use and addiction that is intended for researchers and consumers of research information at all levels. The book is divided into four major sections, including an Introduction, Research Methodology for clinical trials, animal research and retrospective studies, Mechanisms of Use and Addiction, and Investigative Therapeutics: Designing and Measuring Outcomes. It serves a source for addressing all aspects of research design, methods and analysis within the context of the field of opioids, alcohol and other substances. The book covers what is known in the field of quantitative and qualitative research methods, provides future directions, and introduces new models for investigation. It is organized around a translational science framework, with the contents addressing substance use/addiction research in the context of epidemiology, etiology, intervention efficacy and effectiveness, and implementation of evidence-informed interventions. - Presents a practical, easy to read text designed to appeal to both experienced and beginner researchers in the field of substance abuse/addiction science - Provides a concise, well-organized handbook that is a complete guide to methodologies in conducting substance abuse/addiction research - Contains contributions from leading academic institutions - Includes ample diagrams, tables and figures to help organize the information for easy reference, along with a list and explanation of existing useful measurement tools, websites, statistical methods and other resources

Arsenic contamination in drinking water and associated adverse outcomes is one of the major health issues in more than 50 countries worldwide. The scenario is getting even more detrimental with increasing number of affected people and newer sites reported from all over the world. Apart from drinking water, the presence of arsenic has been found in various other dietary sources. Threatening the health of millions of people due to arsenic's toxicity and carcinogenicity, the major routes of arsenic exposure for humans are either through drinking water or crops. This edited volume brings together a diverse group of environmental science, sustainability, and health researchers to address the challenges posed by global mass poisoning caused by arsenic water contamination. The book sheds light on this global environmental issue and proposes solutions to aquatic contamination through multi-disciplinary sustainable approaches and case studies from different parts of world. This book addresses the problem of arsenic by pursuing a holistic approach. It presents the status quo in different parts of the world and provides essential information on food-related arsenic exposure risks for humans and possible preventive and curative measures for tackling arsenic poisoning. The mechanisms of arsenic uptake, translocation, and distribution in plants and grains are also explained. In closing, the book reviews a variety of prospective sustainable solutions to the problem of arsenic accumulation in soil and water.The book comprises three sections. First section describes the routes of exposure to environmental arsenic and its transport in soil and aquatic ecosystems including its source and distribution in specific locations. Second section explains the health risks linked to arsenic exposure in food and the environment. Third section addresses sustainable arsenic contamination mitigation strategies using the potential applications of recent biotechnological techniques, bioremediation, phytoremediation, genetic engineering, nanotechnology, and in silico approaches.The book is intended for a broad audience including researchers, scientists, and readers with diverse backgrounds including agriculture, environmental science, food science, environmental management, and human health. It can also be used as an important reference guide for undergraduate and graduate students, university faculties, and environmentalists. The book may serve as a reference to environment and sustainability researchers, students, and policy makers.

This book reviews the relationship between cytokines, glia, and neurons in the pathophysiology of neuropsychiatric disorders and examines the mechanisms of action of the drugs used for the treatment of these disorders. Increasing evidence has suggested that glia perform important roles in various brain functions, but much remains to be learned about these crucial cells and their interplay with neurons. In addition, a better understanding of the interaction between inflammatory mediators, such as cytokines, and the activated immune response will be of critical importance for the development of new therapeutic strategies. These key areas are the focus of this book, which documents the latest research findings in the field. Evidence is provided for the role of inflammation-induced toxic metabolites from the tryptophan pathway in a wide range of neuropsychiatric disorders, including depression, schizophrenia, and Alzheimer's disease. In presenting state of the art knowledge on the interactions between cytokines, glia, and neurons, the book will help to pave the way for the development of novel targets for the prevention and treatment of neuropsychiatric disorders.

The book presents emerging techniques for the development of latent fingerprint on various surfaces using nanotechnology. It explores the use of nanoparticles for the development of fingerprints. Various topics covered in this book include chemistry of nanomaterials for finger printing, quantum dots in fingerprinting, florescent nanoparticles in fingerprinting, nanocomposite and hybrid materials for fingerprints, carbon-based nanomaterial, silver and gold nanoparticles development of fingerprint, zinc oxide nanoparticles, silica nanoparticles for development of fingerprints, etc. Given the contents, the book will be highly useful for the students, researchers and professionals working in the areas of forensic science and nanotechnology.

This edited volume studies gut microbiota peculiarities in elderly, in senescence-related and environmental-related alterations of gut microbiota in chronic diseases. Aging, as a physiological process mediated through several regulatory pathways and transcription factors, is generally speaking associated to a relentless functional decline and increasing risk of chronic diseases. Growing data on gut microbiota quali-quantitative changes in aging gut, and the opportunity to study by advanced NGS and metabolomic technologies, now offers novel horizons to link such changes to disease risks and to theoretically the weapons for gut microbiota intervention as an effective therapeutic tool. Chapters are divided into clear sections, starting with the aging perspective, then moving from chronic diseases to neurodegenerative diseases and cancer. The final parts focusses on interventions. Contributors are well-reputed and dedicated scientists in clinics and experimentalmedicine from 4 different continents who have provided their contribution keeping the polar star on aging as a guide while investigating their gut microbiota in occurrence and progression of disease together with proposed preventing, monitoring and therapeutic interventions. In the wide offer of books on gut microbiota, this age-thematic volume will be a valuable source of updated information for a wide group of readership including gerontologists, geriatricians, medical specialists of several fields, PhDs, basic scientists and public/private research entities focused on potential intervention in and through gut ecosystem. This book will stimulate a large number of basic scientists and clinicians to review their once organ (or cellular line)-specific knowledge and widen either their pathophysiological mechanisms understanding while providing novel ways to prevent, monitor and treat diseases from eyes to bones.

The book comprehensively reviews the role of nutrition in psychiatric disorders. It provides mechanistic insights into the effects of nutrition on metabolic pathways, mitochondrial nutrients, neurodegeneration and CNS disorders, cell signaling, and neuronal functions. The book further highlights the role of diet in preventing and treating mental health and modifying drug treatment effects. Further, it explores the relationship between nutrition and psychiatric disorders, including depression, autism, anxiety, Attention-Deficit / Hyperactivity Disorder, and OCD. The book further explores the recent advancements in understanding the important role of nutrients as therapeutics in various psychiatric disorders. Lastly, it presents an overview of nutrients as neuroprotective agents along with the main principles of nutrigenomics. The book is essential reading for neuroscientists interested interest in food therapeutic strategies.

This book aims to examine all immunohistochemical and molecular pathological biomarkers that can be useful and effective in patient diagnosis, prognosis and treatment decision, especially when faced with a carcinoma of unknown primary. For this purpose, epithelial malignancies of all systems and related biomarkers are examined one by one, and to look at the subject through the metastatic regions window, biomarkers that can be used to determine the primary focus for carcinomas seen in the areas most frequently metastasized are emphasized. With this bi-directional perspective, the reader is able to find biomarkers of any type of carcinoma on a system basis, as well as access to which biomarkers can be used when faced with a metastatic carcinoma. The importance of biomarkers in patient follow-up and treatment is also conveyed through the clinician's eye, and so biomarkers are handled with a holistic approach in all aspects. This book primarily targets pathologists, as well as clinicians (oncologists and surgeons) who manage cancer patients.

Through five well-regarded editions, Dr. David Dabbs'Diagnostic Immunohistochemistry has set the standard for concise, complete, guidance on the use and interpretation of immunohistochemical stains. The 6th Edition continues this tradition of excellence, bringing you fully up to date with all aspects of this dynamic field. Easy to use and understand, this practical resource distills the large body of information on immunohistochemistry into a single, convenient reference that is invaluable for today's surgical pathologists. - Covers all aspects of the field, with an emphasis on the role of genomics in diagnosis and theranostic applications that will better inform treatment options. - Includes the latest grading schemes in several organs along with new antibodies to cover more genomic immunohistochemistry applications. - Contains current biomarker guidelines and up-to-date references throughout. - Offers a systematic approach to the diagnostic entities of each organ system, including detailed differential diagnoses, diagnostic algorithms, and immunohistograms that depict immunostaining patterns of tumors. - Contains numerous charts and tables, as well as 1,500 high-quality color histologic images that assist in making a definitive diagnosis. - Discusses diagnostic pitfalls through immunohistologic differential diagnosis wherever appropriate so you can provide the most accurate diagnoses. - Covers many more antigens than other texts, and discusses antibody specifications with tables that convey information on uses, clones, vendors, sources, antibody titers, and types of antigen retrieval. - Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices.

Now in its sixth edition, Robert M. Bojar's Manual of Perioperative Care in Adult Cardiac Surgery remains the go-to practical guide for all of those involved in the care of the cardiac surgery patient. Written in outline format, it provides a comprehensive, detailed, and clearly explained review of cardiac surgical disease and perioperative management that is of value to practicing cardiac surgeons as well as to cardiologists, residents, fellows, advanced practice providers, critical care and floor nurses, perfusionists, and medical students. Extensively rewritten with updated references to incorporate the latest concepts, guidelines, protocols, and medications used in cardiac surgical practice, this classic text retains the pragmatic features that have made it the gold standard reference that clinicians have used worldwide for the past 30 years. Highlights include: Full coverage of cardiac surgical diseases, including pathophysiology, indications for surgery per guidelines, and figures of operative procedures and diagnostic techniques, with a panoply of examples Chronologic evaluation of patients from preoperative assessment to intraoperative considerations to postoperative care for each procedure Extensive chapters discussing organ system management in the ICU, followed by a discussion of later postoperative management and problems Incorporation of newer techniques (TAVR, Mitraclip, etc.) within the chronologic format Easy access to information using an outline format, markers on the free edges to identify chapters, synopsis pages at the beginning of each chapter, and a comprehensive index to provide easy referencing within the text Updated references throughout that are available from on-line resources 21 appendices summarizing order sheets, protocols, commonly used drug doses, body mass index, and other important information Praise for the fifth edition:'Surgeons are frequently asked to recommend a text that can be used to guide the care of their patients. This comprehensive text is the standard by which any other text should be judged.'—Critical Care Medicine'It remains a classic and a must have for anyone involved in cardiac surgery.'—Perfusion.com

This book covers the discovery of molecular biomarkers, the development of laboratory testing techniques and their clinical applications, focusing on basic research to clinical practice. It introduces new and crucial knowledge and ethics of clinical molecular diagnosis. This book emphasizes the applications of clinical molecular diagnostic test on health management, especially from different diseased organs. It lets readers to understand and realize precision healthcare.

In this ethnography of the everyday life of contemporary Korea, Denise Lett argues that South Korea's contemporary urban middle class not only exhibits upper-class characteristics but also that this reflects a culturally inherited disposition of Koreans to seek high status. Lett shows that Koreans have adapted traditional ways of asserting high status to modern life, and analyzes strategies for claiming high status in terms of occupation, family, lifestyle, education, and marriage.

Dancing Protein Clouds: Intrinsically Disordered Proteins in Health and Disease, Part B, represents a set of selected studies on a variety of research topics related to intrinsically disordered proteins. Topics in this update include structural and functional characterization of several important intrinsically disordered proteins, such as 14-3-3 proteins and their partners, as well as proteins from muscle sarcomere; representation of intrinsic disorder-related concept of protein structure-function continuum; discussion of the role of intrinsic disorder in phenotypic switching; consideration of the role of intrinsically disordered proteins in the pathogenesis of neurodegenerative diseases and cancer; discussion of the roles of intrinsic disorder in functional amyloids; demonstration of the usefulness of the analysis of translational diffusion of unfolded and intrinsically disordered proteins; consideration of various computational tools for evaluation of functions of intrinsically disordered regions; and discussion of the role of shear stress in the amyloid formation of intrinsically disordered regions in the brain. - Provides some recent studies on the intrinsically disordered proteins and their functions, as well as on the involvement of intrinsically disordered proteins in pthogenesis of various diseases - Contains numerous illustrative materials (color figures, diagrams, and tables) to help the readers to delve in the information provided - Includes contributions from recognized experts in the field

Holbourne's theory that rotational head movement and shear strains were limiting factors in producing acute parenchymal brain damage was a watershed moment in understanding traumatic brain injury (TBI). Long term effects, and in particular neurodegenerative proteinopathy subsequent to TBI, remain theoretical, notwithstanding the poorly understood ‘punch drunk'syndrome of the early and mid-20th century, and the 21st century concept of chronic traumatic encephalopathy. This book, the Handbook of Traumatic Brain Injury and Neurodegeneration, has as its theme the marriage between neurodegenerative disease and neurotrauma through TBI surrogates such as sport, military service, and experimental models, and the legitimacy of that marriage. In the 32 contributions included here, this handbook not only explores the deleterious effects of genuine TBI, but also, and more importantly, the relationship between TBI and neurodegeneration. Controversy notwithstanding, there is much to be learned about the biological effects of TBI, substrates for long-term sequelae, the relationship between TBI and diverse neuropsychiatric disorders, and targets for therapy. The overall message to the neuroscience community from these papers may be a cautionary tale. The null hypothesis, that there is no causal relationship between TBI and progressive neurodegenerative disease, appears to be very much in play, and the book will be of interest to all those working in the field.

Demonstrating the role of nuclear medicine as a complementary technique to mammography and other imaging modalities for the diagnosis of breast cancer, Radionuclide Imaging of the Breast provides a comprehensive overview of scintimammography-an accurate, safe, and noninvasive imaging method for the evaluation of breast lesions and malignancies. Reveals the encouraging results of multicenter clinical trials in the U.S. and Canada using 99mTc sestamibi breast imaging for the diagnosis of primary breast carcinoma! Addressing nonsurgical sampling of nonpalpable breast lesions as an effective means of providing diagnostic and prognostic information, Radionuclide Imaging of the Breastdiscusses increasing the diagnostic value of mammography and its widespread use examines the reliability of FDG-PET and FDG-SPECT in detecting lymph node involvement and distant metastases reviews breast cancer imaging with monoclonal antibodies, including murine and bioengineered antibodies compares the benefits and limitations of Thallium-20l to 99mTc-sestamibi breast imaging in evaluating suspected malignancy assesses the clinical impact of scintimammography as an adjunctive test to mammography to improve the dependability of diagnoses considers the possibility of replacing axillary lymph node dissection in patients with small breast cancers with the sentinel node approach clarifies the importance of surgery in the multimodality treatment of breast cancer elucidates pathologic difficulties for breast cancer diagnosis and more! Radionuclide Imaging of the Breast serves as an essential reference for nuclear medicine physicians, radiologists, breast surgeons, medical and surgical oncologists, gynecologists, pathologists, internists, and primary care physicians.

User-friendly and concise, the new edition of this popular reference is your #1 guide for the appropriate use of immunohistochemical stains. Dr. David J. Dabbs and leading experts in the field use a consistent, organ system approach to cover all aspects of the field, with an emphasis on the role of genomics in diagnosis and theranostic applications that will better inform treatment options. Each well-written and well-researched chapter is enhanced with diagnostic algorithms, charts, tables, and superb, full-color histologic images, making this text a practical daily resource for all surgical pathologists. Features a systematic approach to the diagnostic entities of each organ system, including detailed differential diagnoses, diagnostic algorithms, and immunohistograms that depict immunostaining patterns of tumors. Covers many more antigens than other texts, and discusses antibody specifications with tables that convey information on uses, clones, vendors, sources, antibody titers, and types of antigen retrieval. Discusses diagnostic pitfalls through immunohistologic differential diagnosis wherever appropriate so you can provide the most accurate diagnoses. Contains new material on non-lymphoid malignancies, Hodgkin/non-Hodgkin lymphoma, and an expanded chapter on digital imaging and quantitative immunohistochemistry. Provides new grading schemes for several organs, along with new antibodies to cover more genomic immunohistochemistry applications. Offers more emphasis in the breast section of'eyes on'tissue for molecular/IHC prognostics compared to the current trend of gene-expression profiling of breast cancer. Expert Consult™ eBook version included with purchase. This enhanced eBook experience allows you to search all of the text, figures, and references from the book on a variety of devices.

Radiation Technology for Advanced Materials presents a range of radiation technology applications for advanced materials. The book aims to bridge the gap between researchers and industry, describing current uses and future prospects. It describes the mature radiation processing technology used in preparing heat shrinkable materials and in wire and cable materials, giving commercial cases. In addition, the book illustrates future applications, including high-performance fibers, special self-lubricating materials, special ultra-fine powder materials, civil fibers, natural polymeric materials, battery separator membranes, special filtration materials and metallic nanomaterials. Chapters cover radiation technology in high-performance fiber and functional textiles, radiation crosslinking and typical applications, radiation crosslinking for polymer foaming material, radiation degradation and application, radiation emulsion polymerization, radiation effects of ionic liquids, radiation technology in advanced new materials, and future prospects. - Presents a range of radiation technology applications and their application to advanced materials - Covers the mature radiation processing technology used to prepare heat shrinkable materials and wire cable materials, describing real-world commercial applications - Shows the promising application of radiation technology in preparing high-performance Si and carbon fibers - Describes the radiation degradation/radiation effect used to prepare fine powder materials - Discusses radiation modification and radiation grafting techniques used to synthesize materials, such as civil fibers, natural polymeric materials and others

​This book provides a comprehensive overview of pathology of kidney tumors along with radiological features and up to date treatment strategies that enable the readers to avail this information in day to day pathology sign-out as well as interaction with clinical colleagues of different disciplines. It also serves as a referral resource for the current medical or surgical practice while preparing for examinations or maintenance of certification. Written by experts in the field, chapters contain an updated review of important pathologic parameters mandated for diagnosis and reporting with emphasis on updated information regarding new developments in this interesting field. Numerous high-resolution color images aptly illustrate the various pathologic entities and their features as outlined in the text section along with tables that highlight the differential diagnoses and salient ancillary features. Kidney Cancer serves as a quick reference for all categories of readers alike, and provides up-to-date information on renal tumor pathology, radiology and management that are required in daily practice.

This book comprises select proceedings of the International Conference on Future Learning Aspects of Mechanical Engineering (FLAME 2018). The book gives an overview of recent developments in the field of thermal and fluid engineering, and covers theoretical and experimental fluid dynamics, numerical methods in heat transfer and fluid mechanics, different modes of heat transfer, multiphase transport and phase change, fluid machinery, turbo machinery, and fluid power. The book is primarily intended for researchers and professionals working in the field of fluid dynamics and thermal engineering.

Atlas of Head and Neck Pathology delivers authoritative, highly visual guidance for effectively and accurately diagnosing a wide range of head and neck problems. This comprehensive resource features extensive, high-quality images depicting the histologic, immunohistochemical, cytologic, and diagnostic imaging appearance of every type of head and neck pathology. With a consistent, practical organization and succinct, bulleted format, the Atlas continues to be the resource general pathologists and specialists count on for reliable, easy-to-find answers. - Consult this title on your favorite e-reader, conduct rapid searches, and adjust font sizes for optimal readability. - Reach accurate diagnostic conclusions easily with a consistent, user-friendly format that explores each entity's clinical features, pathologic features (gross and microscopic), ancillary studies, differential diagnoses, and prognostic and therapeutic considerations. - Glean all essential, current, need-to-know information with sweeping revisions that include additional images shown in the frozen section, more content on odontogenic lesions and neoplasms, and inclusion of newly described entities such as igG-associated salivary gland diseases, mammary analog secretory carcinoma, and more. - Review expanded coverage of critical areas with additional chapters on oral cavity and oropharynx, nasopharynx, and neck. - Apply the most current staging of cancers from College of American Pathologists (TNM) and American Joint Committee on Cancer (AJCC). - Interpret the findings you're likely to see in practice with the aid of high-quality images now available online for review or download. - Take it with you anywhere! With Expert Consult, you'll have access to the full text, online, and as an eBook - at no additional cost!

Pediatric tumors comprise a unique set of diseases that may pose diagnostic challenges to pathologists, oncologists, and pediatricians. Pediatric Tumor Pathology: A Practical Approach serves as a state-of-the-art reference for understanding the fundamental biology and diagnostic aspects of pediatric tumors. This volume stands apart from other books covering pediatric neoplasia by providing an in-depth analysis of the pathogenetic and diagnostic aspects of the most commonly encountered tumors. The volume covers the new advances in our understanding of the molecular processes underlying a number of pediatric tumors and the novel, sophisticated diagnostic tools that have now become an integral part of practice standards. Pediatric Tumor Pathology: A Practical Approach will be of great value for many practicing clinicians and pathologists for characterizing and diagnosing childhood tumors. Oncologists, radiologists, surgeons and pediatricians will also find this book a unique and valuable resource for understanding the biological and diagnostic aspects of pediatric tumor pathology.

Enzinger and Weiss's Soft Tissue Tumors is your essential medical reference on the diagnosis of tumors of the skeletal muscles, connective tissue, fat, and related structures. No other source matches Enzinger and Weiss's scope and depth of coverage in this complex and challenging area of surgical pathology, and no other text contains as much practical information on differential diagnosis. Microscopic findings are correlated with the latest developments in molecular biology, cytogenetics, and immunohistochemistry, providing you with a comprehensive and integrated approach to the evaluation of soft tissue specimens.Consult this title on your favorite e-reader, conduct rapid searches, and adjust font sizes for optimal readability.Compare what you see under the microscope to nearly 2,000 superb images that capture the appearance of a complete range of pathological entities and help you relate their characteristics to their specific classifications.Apply the latest knowledge on FNA biopsy, molecular biology, and cytogenetics.Make rapid and effective decisions with the aid of extensive algorithms, and access information at a glance with abundant tables and graphs. Take advantage of all of the essential clinical and prognostic data on soft tissue tumors that are necessary to formulate complete sign-out reports. Navigate through the book quickly thanks to summary outlines at the beginning of each chapter, a color-coded page design, and a consistent approach to every entity. Apply the latest advances in surgical pathology thanks to major updates on recently identified pathological entities such as soft tissue angiofibroma and CIC-related sarcomas; coverage of the newest molecular diagnostic techniques and immunohistochemical and molecular genetic features of soft tissue tumors; new chapters on GIST and soft tissue tumors showing melanocytic differentiation; and more.Effortlessly find the information you need with a chapter organization based on the newest surgical pathology concepts and classifications of soft tissue tumors.

This is Volume V of six in a collection on Ethics and Political Philosophy. Originally published in 1933, it presents a historical analysis of the motivating factors of social conduct.

An international team of accomplished researchers has been assembled to define the role that antioxidants and pro-oxidants play in cancer. Increasing scientific evidence points to the importance of antioxidants and pro-oxidants in both the etiology of cancer development and in cancer treatments. This book should prove useful for research scientists wanting a comprehensive review of the latest accomplishment in this area and for health care-providers who advise patients and the general public about dietary antioxidants and the safety and appropriate use of antioxidant supplements. Endogenous antioxidants systems that play key roles in modulating the in vivo effects of reactive oxygen species (ROS) are reviewed in detail. Many exogenous antioxidants such as vitamin E (tocopherols and tocotrienols), vitamin C, green tea polyphenols, beta-carotene and curcumin are individually discussed as well as their potential roles in alternative and complementary medicine approaches to cancer prevention and treatment. For public health professionals the question of whether or not antioxidants have a safe chemopreventive role is central: it is clearly much more effective to prevent cancer than deal with its consequences including the damaging side effects of many chemotherapeutics. A key theme explored throughout this book is the cancer-related events arising from oxidative stress and the over production of ROS. On the one hand, oxidative stress has been linked to DNA damage, mutations and an increased risk of cancer. Quite remarkably, cancer cells often exhibit a high level of intrinsic oxidative stress that is fundamental to the expression of many cancer phenotypes. The molecular mechanism whereby ROS modulate cell signaling pathways related to cancer phenotypes is, therefore, carefully reviewed. One chapter, based on original research, describes a novel methodology for measuring the cellular production of specific reactive oxygen species. A most important question is whether or not antioxidants can reduce the incidence of cancers or block the expression of cancer phenotypes. Oxidative stress in cancer cells is, however, a dual-edged sword and many cancer therapies rely on using an additional oxidative stressor to selectively drive cancer cells into programmed cell death. The high level of intrinsic oxidative stress expressed by many cancer cells has often been called the “Achilles'heal” of cancer. A second question is whether antioxidants could negatively interfere with pro-oxidant based cancer therapies. These two questions and related issues are addressed in this book. Pharmacologists with an interest in the rationale design of drugs and prodrugs for treating cancer by exploiting its high level of intrinsic oxidative stress will also benefit from this book since this issue is specifically addressed in a number of chapters. Issues related to antioxidants and pro-oxidants are also discussed in relationship to specific cancers such colorectal cancer, pancreatic cancer and prostate cancer.

Diagnostic Immunohistochemistry presents the latest information and most reliable guidance on immunohistological diagnoses in surgical pathology. David J. Dabbs, MD and other leading experts bring you state-of-the-art coverage on genomic and theranostic applications, molecular anatomic pathology, immunocytology, Non-Hodgkin's lymphoma, and more. Additional features such as tables discussing antibody specifications, differential diagnosis boxes, ancillary anatomic molecular diagnostics, and full-color histological images ensure user-friendly coverage that makes key information easy to find and apply. This concise and complete resource is today's indispensable guide to the effective use of immunohistochemical diagnosis.Discusses diagnostic pitfalls through immunohistologic differential diagnosis wherever appropriate so you can provide the most accurate diagnoses.Presents chapters arranged by organ system for comprehensive coverage of all relevant information in a convenient and intuitive organization.Provides quick reference graphs for antibodies throughout the text that illustrate the frequency of immunostaining for a variety of antibodies in tumors.Includes Key Diagnostic Points boxes in every chapter for a quick summary of text areas that are of particular importance.Features an expert author for each chapter to ensure coverage of the current state of the art.

Information engineering and applications is the field of study concerned with constructing information computing, intelligent systems, mathematical models, numerical solution techniques, and using computers and other electronic devices to analyze and solve natural scientific, social scientific and engineering problems. Information engineering is an important underpinning for techniques used in information and computational science and there are many unresolved problems worth studying. The Proceedings of the 2nd International Conference on Information Engineering and Applications (IEA 2012), which was held in Chongqing, China, from October 26-28, 2012, discusses the most innovative research and developments including technical challenges and social, legal, political, and economic issues. A forum for engineers and scientists in academia, industry, and government, the Proceedings of the 2nd International Conference on Information Engineering and Applications presents ideas, results, works in progress, and experience in all aspects of information engineering and applications.

Integrative Therapies in Lung Health and Sleep provides an overview of integrative therapies to assist clinicians caring for patients with acute or chronic lung diseases and sleep disorders--emphasizing the scientific bases for these therapies; and their implementation into clinical practice. This volume focuses on complementary and alternative medicine (CAM) treatments, modalities, and practices that are integrated with conventional medical treatment and for which there is some evidence of safety and efficacy. Whole Medical Systems, with a specific focus on Traditional Chinese Medicine, are also addressed. Individual chapters are devoted to specific health conditions or illnesses, addressing the current state of the science in the four organizing CAM domains, including available information regarding benefits, risks, or safety considerations. Unique aspects of this volume are the chapters related to evaluation of the evidence base for integrative therapies; new animal model research with herbal preparations focused on the serious problem of sepsis in the ICU; guidance for counseling patients with chronic lung illnesses who may be desperate for a cure; and palliative and end-of-life care for patients with chronic lung conditions. Clinicians in various health care settings will find Integrative Therapies in Lung Health and Sleep beneficial in their practice, particularly as the use of integrative therapies becomes more widespread.

Der vorliegende Band „Mamma, Weibliches Genitale, Schwangerschaft und Kindererkrankungen“ enthält eine systematische Darstellung der pathologischen Veränderungen der genannten Organe, Organsysteme und Erkrankungsgruppen. Dabei werden alle Erkrankungen, die sich in den verschiedenen, zum Teil miteinander funktionell verbundenen, zum Teil unabhängig voneinander existierenden Organen beobachten lassen, beschrieben. Die Verfasser der verschiedenen Unterkapitel sind renommierte europäische Pathologen aus den verschiedenen Arbeitskreisen, die sich mit den o. g. Themen diagnostisch und wissenschaftlich intensiv beschäftigen. Dabei wird insbesondere auf die modernen Entwicklungen der verschiedenen Teilbereiche eingegangen und die neuen Veränderungen in Terminologie, Klassifikation und molekularen Analysen detailliert dargestellt. Dieses stets unter dem Blickwinkel der diagnostischen Pathologie. Insgesamt ist das Ziel der vorliegenden Kapitel, Grundlage und Informationsquelle für die tägliche diagnostische Arbeit auf hohem Niveau zu sein.

With very few exceptions, eukaryotic cells possess two interdependent genomes, chromosomal and extra-chromosomal. Over the past several decades, cancer - search has focused primarily on deciphering the intricate alterations in the chro- somal genome, with until recently, very little attention to its cytoplasmic counterpart. In spite of the enormous complexity of the nuclear genome, which we now fully appreciate after completion of the human genome project, the efforts of cancer researchers are commendable in terms of the tremendous gains made in unraveling the numerous genetic changes in cancer. These changes include d- coveries of tumor suppressor genes, oncogenes, and caretaker genes that are often mutated in cancer. Recent studies of genomic pro?les are uncovering even more altered and mutated genes in cancer. Besides these?ndings, several therapeutic targets for chemotherapy are currently made from studies of altered nuclear genetic pathways. Inspite of all these positive efforts, the war on cancer, declared in 1971 by Richard Nixon, is far from being worn. Indeed, the failure of chemotherapy is obvious to clinicians, oncologists, and their patients alike. Moreover, the global incidence and prevalence of cancer continue to rise. What are we missing? Which direction should we be taking? Of course, modern integrated nuclear genomics, proteomics, and metabolomics should provide important clues to carcinogenesis, but the contribution of cytoplasmic genetic alterations to carcinogenesis cannot be neglected.

Diagnostic Immunohistochemistry presents the latest information and most reliable guidance on immunohistological diagnoses in surgical pathology. David J. Dabbs, MD and other leading experts bring you state-of-the-art coverage on genomic and theranostic applications, molecular anatomic pathology, immunocytology, Non-Hodgkin's lymphoma, and more. Additional features such as tables discussing antibody specifications, differential diagnosis boxes, ancillary anatomic molecular diagnostics, and full-color histological images ensure user-friendly coverage that makes key information easy to find and apply. This concise and complete resource is today's indispensable guide to the effective use of immunohistochemical diagnosis. Discusses diagnostic pitfalls through immunohistologic differential diagnosis wherever appropriate so you can provide the most accurate diagnoses. Presents chapters arranged by organ system for comprehensive coverage of all relevant information in a convenient and intuitive organization. Provides quick reference graphs for antibodies throughout the text that illustrate the frequency of immunostaining for a variety of antibodies in tumors. Includes Key Diagnostic Points boxes in every chapter for a quick summary of text areas that are of particular importance. Features an expert author for each chapter to ensure coverage of the current state of the art. Provides guidance on the role of genomics in identifying genetic and molecular aspects of disease that may affect patient care and therapeutic approaches. Covers theranostic applications to enable you to evaluate therapeutic choices based on immunohistochemical results. Reflects the latest developments in the field through new chapters on molecular anatomic pathology and immunocytology, as well as updated chapters on immunohistology of the prostate, bladder, testis, and kidney and Non-Hodgkin's lymphoma. Discusses antibody specifications with tables that convey information on uses, clones, vendors, sources, antibody titers, and types of antigen retrieval. Presents key differential diagnoses boxes that provide tabular summaries of DDx and algorithms. Features discussions of ancillary anatomic molecular diagnostics as an adjunct to immunohistochemistry for a more well-rounded diagnostic approach.

The Second International Conference on Fuzzy Information and Engineering (ICFIE2007), built on the success of previous conferences, the ICIKE2002 (Dalian China), is a major symposium for scientists, engineers and practitioners in China as well as the world to present their latest results, ideas, developments and applications in all areas of fuzzy information and knowledge engineering. It aims to strengthen relations between industry research laboratories and universities, and to create a primary symposium for world scientists in fuzzy fields such as Fuzzy Information, Fuzzy Sets and Systems, Soft Computing, Fuzzy Engineering, Fuzzy Operation Research and Management, Artificial Intelligence, Rough Sets and Its Application, Application in Fuzzy Mathematics and Systems, etc.

This unique one-volume handbook provides a quick and concise reference guide for practising ophthalmologists, retinal specialists, vitreo-retinal fellows, ophthalmology residents and optometrists on the latest recommendations for managing common vitreo-retinal disorders seen in everyday retina practise. It provides comprehensive and essential information on diagnosis and management in outline and table format for conciseness and quick access. Color illustrations of important clinical manifestations are provided in an appendix.Dr Susanna Park is a Professor of ophthalmology and Director of Vitreo-retinal Fellowship and Ocular Oncology at the University of California Davis Eye Center. She has over 20 years clinical experience as a vitreo-retinal specialist and published over 100 journal papers and book chapters on the subject.