Search

This book is a ground-breaking that delves into the fascinating world of metabolism and its pivotal role in the survival, attack, and defense strategies in human-microbe interaction. This book explores the intricate biochemical processes that enable organisms to thrive, adapt, and protect themselves against various challenges they encounter in their environments. The book will describe the importance of metabolism in defense and attack by bacteria and fungi in the human microenvironment and the reverse immuno-metabolic responses by the human. Different metabolites from different organisms will be described, in addition to their changes due to interaction with other organisms during infection or defense. The book also will describe the methods of detection and identification of metabolites including metabolomics. The use of artificial intelligence in prediction of metabolic patterns following interaction between different organisms will be included as well. The metabolism in microbiome will be described in relation to infection, and other metabolic diseases, in addition to their effects on therapeutic drugs. The book combines the latest scientific research with accessible explanations, providing readers with a deep understanding of how metabolism empowers organisms to thrive and protect themselves in diverse environments. It will be an invaluable resource for researchers, students, physicians, and anyone fascinated by the wonders of biology and the intricate workings of life.

'Fast Facts: The Gut Microbiome', though pithy and concise, is amazingly comprehensive and takes the reader through all major aspects of the human gut microbiome and microbiome science. The depth of Professor Shanahan's knowledge of the science of the microbiome is evident throughout but what transforms this volume from a mere recitation of what we know to a truly critical and accessible exposition on what matters is the critical eye of the clinician who must make decisions that will affect a patient's health.

This book is a comprehensive guide on microbiome research, from the fundamentals of to the latest advancements in microbiome-based therapeutics. The initial chapters introduce the concept of the human microbiome delving into the intricate relationship between the human host and its microbiome. The chapter also examines the various tools and techniques used in microbiome research and the role of computational biology in analyzing vast amounts of microbiome data. The subsequent chapters review the role of the microbiome in various health conditions, including metabolic disorders, immunological disorders, gastrointestinal tract disorders, management of cancers, metabolic disorders, and mental health disorders. Towards the end, the book examines the regulatory considerations surrounding microbiome-based therapeutics, and ethical considerations surrounding microbiome-based therapeutics. This book is a comprehensive and cutting-edge guide for researchers, healthcare professionals, and students interested in the field of microbiome research and its potential for transforming healthcare.

Pour répondre au défi­ de la sécurité immunologique transfusionnelle, cet ouvrage propose un panorama complet des données actuelles en immuno-hématologie en présentant les différents systèmes de groupes sanguins érythrocytaires chez l'être humain et les bases de leur polymorphisme. Cette 2e édition intègre les récentes évolutions (9 nouveaux systèmes depuis la précédente édition) et les dernières innovations génomiques. • Système après système, les fondamentaux sont développés : l'histoire de la découverte, la classi­fication des antigènes et phénotypes, les gènes et la diversité génique, la répartition membranaire et tissulaire des antigènes, les anticorps les reconnaissant. • Sont également abordées dans chaque chapitre, les liaisons entre phénotypes et pathologies, la sensibilité des antigènes aux traitements enzymatiques et leur implication clinique dans les phénomènes d'auto-immunité. • Les auteurs font ensuite le point sur des aspects transversaux comme les antigènes HLA, la poly-agglutinabilité, la variabilité des fréquences, l'anthropologie génétique… Conçu de façon didactique, cet ouvrage s'adresse aux hématologues, biologistes et transfuseurs et se veut un outil pour répondre aux défi­s posés par la transfusion sanguine. Il permet au lecteur spécialisé de trouver une réponse à la majorité des questions qui concernent les antigènes et gènes des groupes sanguins érythrocytaires.

This open access book presents the final findings from the case studies developed within the Horizon 2020 SMOOTH project Educational Spaces. Passing through Enclosures and Reversing Inequalities through Educational Commons. The overall objective of the project was to understand, develop, and accelerate the potential impact of education on reversing inequalities for active social inclusion of children and young people at risk in Europe, through introducing the emergent paradigm of the “commons” as an alternative value and action system in the field of education (preschools, schools, and after-school programs). SMOOTH critically draws out the implications of the commons for refiguring education and for social change in general, on a footing of equality, sharing, participation, togetherness, caring, and freedom. Universities, research laboratories, municipalities, NGOs, museums, and youth organizations, in different European countries, have worked together to achieve the aboveaim involving almost 200 educators and teachers, and 800 children, and providing interesting insights and suggestions on how to implement educational commons in many different educational contexts. The target audience comprises policymakers and education leaders, students from Education and Communication degrees, researchers, and educators from both formal and non-formal educational contexts.

The Rose-Mackay Textbook of Autoimmune Diseases, Seventh Edition is a comprehensive reference that emphasizes the'3 P's'of 21st Century medicine: precision, prediction, and prevention. Topics cover the modern systems approach to biology that involves large amounts of personalized, ongoing physiologic data ('omics') coupled with advanced methods of analysis, new tests of genetic engineering, such as CRISPR, auto inflammatory diseases, autoimmune responses to tumor immunotherapy, and information on normal immune response and disorders. Each of the major autoimmune disorders is discussed by researchers and clinical investigators experienced in dealing with patients. This new edition continues its success with 75% of the content revised, updated, or completely new. This edition is a valuable resource to clinicians involved in the diagnosis and treatment of autoimmune disease, as well as to scientists who want to follow developments in the field. - Provides new research on autoimmune diseases, their diagnosis, prevention, and therapy - Covers a complete range of all common, rare and new autoimmune diseases, including cancer and COVID - Extensively revised with 75% new material based on autoimmunity, developments in the different diagnosis and therapies for these autoimmune diseases, and a completely updated description of the different diseases - Supplemented with a website that hosts a Podcast per chapter

Environmental Pollution and Type 2 Diabetes Mellitus is a novel resource to understand the global impact of environmental pollution and how it increases diabetes mellitus. Over the past three decades, environmental pollution has been an emerging global public health problem in developing and developed nations. The swift urbanization and industrial revolution increased environmental pollution to a hazardous level. Environmental pollution is a leading risk factor for several well-known diseases. This book opens venues for students, physicians, researchers, the science community, and policymakers to enhance their knowledge about environmental pollution, weather conditions, climate change, and their impact on insulin resistance and mechanisms allied to Type 2 diabetes mellitus (T2DM). Moreover, this book will provide knowledge about the green space environment and its impact on T2DM. - Offers unique scientific information, facts, and figures about environmental pollution and T2DM - Highlights the air pollution condition of different countries on various continents and mechanisms allied to developing T2DM - Provides information about countries highly polluted and countries less polluted, along with the epidemiological trends of T2DM

Much has been written about food allergies in scientific journals and in the lay press, but Food Allergies: Processing Technologies for Allergenicity Reduction approaches the issue of food allergies from an industrial processing rather than a clinical perspective.Indeed, industrial food processing technologies can have many beneficial effects to obtain various food products and to preserve foods from physical, chemical and microbiological alterations. However, processing technologies, including thermal and non‑thermal technologies, can also alter the allergenic properties of food proteins.This book provides an authoritative source of information on the relationship between food processing technologies and food allergens with a greater variety of studied allergens including peanuts, tree nuts, cow's milk, eggs, sesame, lupine, soy, wheat, mustard, mushroom, fish and shellfish, as well as the importance of processing these when producing hypoallergenic foods.Key Features: Presents food allergies with recent advances and statistics concerning prevalence, physiopathologic mechanism, diagnosis and anaphylaxis Discusses food allergies in the food industry and investigates the effect of processing on allergenicity of foods during manufacturing Provides food processing and promising technologies to produce hypoallergenic food with high quality Covers the allergenic effect of different food additives with an investigation of cross‑reaction risks This unique book is an indispensable guide for allergic patients, production managers, scientists and nutritionists within the food industry as well as covering a range of critical topics in this area for all those concerned with understanding and managing food allergies.

Der Begriff menschliches Mikrobiom hat sowohl in der Wissenschaft als auch in der Öffentlichkeit in letzter Zeit große Aufmerksamkeit gefunden. Das Buch führt den aktuellen Forschungsstand des gastrointestinalen Mikrobioms und seinen Einfluss auf eine Vielzahl an Erkrankungen zusammen und benennt neue therapeutische Möglichkeiten, die sich aus den Erkenntnissen ergeben. Internisten, Fachärzte anderer Disziplinen und andere interessierte Fachgruppen erhalten einen Überblick neuer wissenschaftlicher Konzepte. Namhafte Experten aus der Mikrobiom-Forschung erläutern diagnostische und therapeutische Ansätze für die Themenfelder der onkologischen Erkrankungen, Adipositas, Infektionserkrankungen, Neurodegenerative Erkrankungen wie auch den gastrointestinalen funktionellen Krankheitsbildern wie Reizdarmsyndrom oder FD. Eine gute Orientierung bietet das Buch bei der wachsenden Zahl von Studien - unter funktionellen Gesichtspunkten und hinsichtlich von Einsatzmöglichkeiten der zunehmenden Erkenntnisse für die Diagnostik, Prophylaxe und Therapie von Erkrankungen. Es werden Zusammenhänge zwischen Gesundheit und Krankheit und mikrobiellen Konsortien sowie Funktions-Zuschreibungen an bakterielle Spezies und ihre metabolischen Charakteristika vorgenommen. Weiterhin wird die Funktion kommensaler bakterieller Gemeinschaften und der Einfluss dysbiotischer Veränderungen auf die Gesundheit erläutert. Auch die Einflüsse des Mikrobioms auf die Wirksamkeit pharmakologischer Interventionen (z.B. Checkpointinhibitoren) werden als neues relevantes Feld der Mikrobiom-Forschung besprochen.

This reference work is strong informative about the role of the gut microbiome in organism metabolism and fully discusses the relationship between gut alterations and/or gut microbiome-derived metabolites and the pathogenesis of many diseases, as well as recent advances in clinical applications of microbiome and microbial effector molecules.It clearly shows how the microbiome research is a growing field in molecular and clinical sciences, due to technical advances based on high throughput genetic sequencing technologies and omics analyses that empower systems biology-based methods for precision health monitoring and treatment. It will help in understanding that high diversity of the microbial communities in the gut is important to preserve health and microbiome alterations, not only in nutrition associated diseases like obesity and diabetes, but also in many chronic inflammatory, cardiovascular, oncological and neurological disorders. Written by renown experts in the field,this reference work is intended for clinicians, residents, specialists and physicians involved in the diagnosis and treatment of affected patients. It is published as part of the SpringerReference program, which provides access to live editions constantly updated through a dynamic peer-review publishing process.

This book pinpoints one of the fastest growing, complex subjects in chemistry and medical science: the dangers of oxidative stress to human beings. It provides a solid background on the chemistry behind the generation of reactive species as well as how reactive species are involved in essential physiological processes and in almost every human disease. It also covers the most recent developments in the study of oxidative and reductive stress (redox stress), including the role of radical and reactive species, novel antioxidant therapies, and methods for assessing free radicals and redox stress. The chapters present concise, yet thorough, summaries of the state-of-the-art methods and techniques that any investigator working in the oxidative/reductive stress field needs to access. The current methodologies including the development of sensors and biosensors for the detection of ROS/RNS/RHS and of biomarkers of redox stress are thoroughly discussed. This book is a useful resource for all researchers and students interested in oxidative stress, molecular biology, and chemistry. Physicians and healthcare professionals interested in understanding the molecular mechanisms underlying the redox stress-related diseases also stand to benefit from this book.

This book will explore the knowledge of current diagnostic automation techniques applied in the field of clinical microbiology, tropical diseases, POCT, etc. There is no such type of book related to this topic. This book will help clinicians, microbiologists, and researchers to make diagnostic algorithms for infectious diseases and help them in early diagnosis. Automation in clinical microbiology has revolutionized routine practice in diagnostic cum research in medical microbiology. This book covers the recent updates and advances in diagnostic microbiology and provides new techniques related to Genomic, Proteomic, and metabolomics in microbiology. This book will intensely discuss the new and innovative automation techniques available for diagnosis in the microbiology laboratory. This book is more focused on automation techniques, which are used in the early detection of infectious diseases even caused by rare microorganisms. Furthermore, this book has complied with the chapters that provide insights to readers with comprehensive and usable knowledge on automation techniques in diagnostic microbiology.

This book, Gut microbiome and Brain Ageing, deals with the mechanisms and phenomenon that relates gut microbiome and aging of the brain. This book will bring forth the connection between good gut and brain aging and includes some cutting edge research topics dealing with gut physiology and its importance as future therapeutic option in neurological disorders. The gut microbiome's impact on neuronal function, mediated by neurotransmitters, vitamins, and neuroactive microbial metabolites, is an exciting area of investigation that this book thoroughly explores. It also covers the pivotal role of the gut microbiome in the etiology of various neurodegenerative disorders such as Alzheimer's disease (AD), Parkinson's disease (PD), depression, or multiple sclerosis (MS). It also explores the expanding understanding of the importance of the early-life gut microbiota and its implications for long-term health consequences. This book primarily addresses researchers, clinicians, and doctoral andgraduate students working in biomedicine, neurobiology, nutrition, microbiology, and translational medicine streams.

The Latin American region has been at the forefront in combating infections caused by Escherichia coli strains in humans, animals, and the environment. The continuous emergence and evolution of pathogenic E. coli strains associated with human and animal infections have demonstrated that (i) groups of related pathogenic E. coli are responsible for most infections caused by this bacterial species; (ii) diverse virulence phenotypes expressed during infection defined each one of these pathogroups; (iii) the geographical distribution of pathogroups in Latin America and the evolution of new isolates was defined by the dominant pathogroup and presence of distinct virulence strains; (iv) acquisition of mobile elements or accumulation of point mutations accelerate the development of antibiotic resistance in some of these strains. The Latin American Coalition for Escherichia coli Research (LACER), a multidisciplinary network of over seventy research groups in eleven Latin American countries and the USA, was established in 2009 to apply One Health principles in defining and combating this pathogen. The previous edition of this text, Escherichia coli in the Americas (c. 2016) was the culmination of their wisdom about E. coli, from its role as a commensal bacterium to its characteristics as a pathogen causing disease in animals and humans. This new edition presents recent advances and contextualizes all aspects of E. coli in a One Health perspective, from the environment, to animals, to humans. It addresses E. coli interactions with host microbiota, CNS, and phages. It includes cutting edge insights on hybrid strains, molecular mechanisms of virulence and pathogenesis, resistance, domestic and wild reservoirs, disease surveillance in Latin America, genomic analysis, food safety, and new therapies. Crucially, it also provides translations and analysis of key reports on Escherichia colipublished in Spanish and Portuguese. This book serves as a critical resource for scientists in industry and academia, clinicians managing associated infections, and trainees and students studying basic and clinical aspects of E. coli pathogenesis.

This book provides a unique, comprehensive, and up-to-date overview of the various NADPH oxidases and narrates the history of their discovery, biochemical characteristics, genetics, molecular structure, and multiple functions in health and disease. It covers the subject in a manner that serves both the expert and the novice researcher in the field.The book starts with an overview of the major milestones in the discovery of the archetypical NADPH oxidase, known as cytochrome b558, and its cytosolic regulators. This is followed by personal recollections by pioneers of the field, descriptions of the work of the major figures of the past by their followers, and a rendering of the history of the discovery of the Nox family. The central section of the book consists of chapters devoted specifically to an in depth description of the individual members of the Nox family, and is followed by chapters focused on the modulators of their function. A subsequent section comprises chapters dealing with methodologies of Nox research, interaction with other proteins, and Nox inhibitors. A distinct section of the book deals with non-mammalian Noxs, from amoeba to zebrafish. Subsequent chapters focus on Nox structure, a field in which extraordinary progress was made in recent years. The volume ends with chapters on Chronic Granulomatous Disease, the consequence of Nox loss-of-function, and its treatment by gene therapy. The coda is a crystal ball perspective of the hopes for the clinical translation of basic Nox research. Written for biochemists, cell biologists, molecular biologists, and clinicians, this book is aimed at both senior scientists and young investigators in the field.

This volume explores in detail the molecular biology, genetics and immunology of the bacterium Helicobacter pylori that causes serious gastric diseases such as gastric cancer. The book provides in-depth insights into the mechanisms of H. pylori-induced pathogenicity, gives an overview of how the bacterium colonizes the human gut, how it manages to persist in the body and which factors play a role in the development of H. pylori-induced gastric cancer. Furthermore, the interaction between the Gram-negative bacterium and the human gut microbiome is explored, and clinical management and treatment strategies to combat gastric cancer are discussed.Helicobacter pylori is an extremely successful pathogen that persistently colonizes the gut of about 50% of the world's population. H. pylori and its human host share a long co-evolutionary relationship that dates back for at least last 100,000 years and possibly longer. Infection by thisbacterium is a high-risk factor for the development of gastric diseases, including gastric cancer. Gastric cancer is associated with high morbidity and mortality and represents the 5th most common malignant tumour and the 4th leading cause of cancer-related death worldwide. H. pylori is the first bacterium that has been classified as a type-I carcinogen by the International Agency for Research on Cancer (IARC). Recent research progress identified crucial bacterial, host and environmental factors which control H. pylori-induced gastric malignancy. New studies also suggest that specific human germline mutations and other genetic aberrations have an important impact on H. pylori-induced pathology. In this volume, all these recently discovered mechanisms are reviewed in the light of gastric cancer development, and H. pylori epidemiology, virulence factors, immune evasion, pathophysiology, cancer signalling and novel therapeutic protocols are presented. This volume is aimed at researchers in the fields of immunology, genetics, microbiology and medicine who are interested in the detailed mechanisms of the pathogenicity of this carcinogenic stomach bacterium.

Covering both the scientific basis of rheumatology and practical, clinical information for rheumatologists and trainees, Rheumatology, 8th Edition, remains a leading text in this fast-changing field. Dr. Marc Hochberg and his team of worldwide editors and authors keep you abreast of recent advances in the field— all in a user-friendly, accessible manner. Fully updated from cover to cover, this two-volume text is designed to meet the needs of all practicing and academic rheumatologists as well as arthritis-related health care professionals and scientists interested in rheumatic and musculoskeletal diseases. - Covers the epidemiology, pathogenesis, clinical manifestations, therapeutic approach, and management of all major as well as rarely encountered rheumatic and musculoskeletal diseases. - Discusses clinical examination, imaging principles, differential diagnosis, established and novel therapies, perioperative evaluation, pain management, basic science, and genetics of rheumatic and musculoskeletal diseases. - Uses a consistent, logical, reader-friendly format with templated chapters, concise text, and large-scale, state-of-the-art illustrations for efficient visual reference. - Contains new chapters covering pre-clinical disease and how to address these patients, common comorbidities in rheumatoid arthritis; emerging therapies for systemic sclerosis; immune mediated complications of checkpoint inhibitors; the epidemiology of COVID-19 and rheumatic and musculoskeletal diseases, emerging treatments for osteoarthritis, and big data analytics. - Provides updates to key topics such as systems biology and its impact on our understanding of the pathogenesis of rheumatic and musculoskeletal diseases, the microbiome in rheumatic musculoskeletal diseases, how to manage chronic pain in the patient with a rheumatic disease, drugs and reproductive health, and emerging therapies for patients with RA, SLE, spondyloarthritis, inflammatory muscle disease, and vasculitis. - Shares the knowledge and expertise of numerous new contributing authors, as well as new co-editor Dr. Désirée van der Heijde, who is an expert in psoriatic arthritis, spondyloarthritis, imaging, and clinical epidemiology. - Provides access to concise videos depicting the use of ultrasound for diagnosis and treatment. - Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices. If you encounter issues with your eBook please contact Elsevier eBook+ support via textbookscom.support@elsevier.com.

Epigenetics in Human Disease, Third Edition examines the diseases and conditions on which we have advanced knowledge of epigenetic mechanisms, such as cancer, autoimmune disorders, aging, metabolic disorders, neurobiological disorders and cardiovascular disease. From molecular mechanisms and epigenetic technology to clinical translation of recent research, the nature and applications of the science is presented for those with interests ranging from the fundamental basis of epigenetics to therapeutic interventions for epigenetic-based disorders, with an emphasis throughout on understanding and application of key concepts in new research and clinical practice. Fully revised and up-to-date, this Third Edition discusses topics of current interest in epigenetic disease research, including stem cell epigenetic therapy, bioinformatic analysis of NGS data, epigenetic mechanisms of imprinting disorders, microRNA in cancer, epigenetic approaches to control obesity, epigenetics and airway disease, and epigenetics in cardiovascular disease. Further sections explore online epigenetic tools and datasets; early-life programming of epigenetics in age-related diseases; the epigenetics of addiction and suicide, and epigenetic approaches to regulating and preventing diabetes, cardiac disease, allergic disorders, Alzheimer's disease, respiratory diseases, and many other human maladies. In addition, each chapter now includes chapter summaries, definitions, and vibrant imagery and figures to reinforce understanding, as well as step-by-step methods and disease research case studies. - Includes contributions from leading international investigators involved in translational epigenetic research and therapeutic applications - Integrates methods and applications with fundamental chapters on epigenetics in human disease, along with an evaluation of recent clinical breakthroughs - Presents side-by-side coverage of the basis of epigenetic diseases and treatment pathways - Each chapter updated to include summaries, definitions, and vibrant imagery and figures to reinforce understanding - Features step-by-step methods and disease research case studies to put book concepts into practice

Use THE definitive reference for laboratory medicine and clinical pathology! Tietz Textbook of Laboratory Medicine, 7th Edition provides the guidance necessary to select, perform, and evaluate the results of new and established laboratory tests. Comprehensive coverage includes the latest advances in topics such as clinical chemistry, genetic metabolic disorders, molecular diagnostics, hematology and coagulation, clinical microbiology, transfusion medicine, and clinical immunology. From a team of expert contributors led by Nader Rifai, this reference includes access to wide-ranging online resources on Expert Consult — featuring the comprehensive product with fully searchable text, regular content updates, animations, podcasts, over 1300 clinical case studies, lecture series, and more. - Authoritative, current content helps you perform tests in a cost-effective, timely, and efficient manner; provides expertise in managing clinical laboratory needs; and shows how to be responsive to an ever-changing environment. - Current guidelines help you select, perform, and evaluate the results of new and established laboratory tests. - Expert, internationally recognized chapter authors present guidelines representing different practices and points of view. - Analytical criteria focus on the medical usefulness of laboratory procedures. - Use of standard and international units of measure makes this text appropriate for any user, anywhere in the world. - Elsevier eBooks+ provides the entire text as a fully searchable eBook, and includes animations, podcasts, more than 1300 clinical case studies, over 2500 multiple-choice questions, a lecture series, and more, all included with print purchase. - NEW! 19 additional chapters highlight various specialties throughout laboratory medicine. - NEW! Updated, peer-reviewed content provides the most current information possible. - NEW! The largest-ever compilation of clinical cases in laboratory medicine is included with print purchase on Elsevier eBooks+. - NEW! Over 100 adaptive learning courses included with print purchase on Elsevier eBooks+ offer the opportunity for personalized education.

This book synthesizes important areas of research and clinical focus in the gut microbiome and provides an up-to-date reference for clinicians seeking to expand their knowledge. The breadth and complexity of gut microbiome research makes it difficult for physicians and clinicians to access information. To aid readers, Clinical Understanding of the Human Gut Microbiome integrates a variety of human gut microbiome research so that physicians and clinicians can then make the best decisions in the care of their patients. The book will provide an overview of the different players in the gut microbiome, including bacteria, yeast and other fungi, archaea, parasites, and viruses. It also describes how these microbes and their products and metabolites influence diverse clinical areas including diabetes, functional gastrointestinal disorders, colorectal cancer, and neurological disorders such as Parkinson's disease and the potential of emerging treatments. Clinical Understanding of the Human Gut Microbiome is an important resource for physicians and clinical researchers looking to understand the human gut microbiome.

This book celebrates the emergence of knowledge in the field of pediatric gastroenterology (GI) and is written for the primary care clinician to help update knowledge in this important area. The current and future shortage of pediatric gastroenterologists necessitates steady, rejuvenated information on GI disorders for primary care clinicians as they care for the child and adolescent with complex gastroenterologic dilemmas and disorders. Much has been learned about pediatric gastroenterology and hepatology in the 21st century as research continues around the world despite many challenges such as the 2019-2023 COVID-19 pandemic. This second edition of the editors/writers'discussion on pediatric gastroentologic (GI) and hepatic disorders reflect on such updated knowledge that considers medical and surgical perspectives including dealing with such complex complications as infection and pain.

The rapidly increased understanding of the molecular background of complex diseases facilitated the development of highly advanced therapeutic concepts. Such concepts aiming to consider individual signatures of genomic and proteomic biomarkers including pharmacogenomics as well as advanced diagnostic tools have been successfully implemented in clinical practice in various fields leading to significant improvement of treatment successes. This volume gives an up-to-date overview on applications of precision medicine in various clinical entities, on advanced techniques as well as on economic considerations.

This third edition brings together the latest in research and clinical practice of the expanding field of pediatric neurogastroenterology. In addition to a comprehensive review of the current state of the art, many chapters have been significant revised and updated, covering the latest discoveries of the delicate and detailed mechanisms of the neuroenteric system as well as relationships of the latter with microbiota and metabolites produced by resident intestinal bacteria. The book also covers rapidly-changing techniques to assess clinical problems, along with international diagnostic criteria and recommendations and guidelines for clinical management. The content is supported by ample figures, photographs and selected video segments.Remaining the gold standard text in this up-and-coming field, Pediatric Neurogastroenterology 3e is dedicated to reporting the most accurate and recent knowledge available. Written by international experts in the field, the bookis a comprehensive and up-to-date theoretical review and practical guide to pediatric gastrointestinal motility and functional disorders to pediatricians, pediatric gastroenterologists and all professionals involved in the treatment of children with such disorders.

This book presents an edited collection of critical discourse situated in the fields of diversity and inclusion broadly, and more specifically, within the discipline of education. Each chapter articulates the importance of educational diversity in achieving the United Nations Sustainable Development Goal 4. The edited collection presents a grounding narrative of equitable learning opportunities and experiences via interpretivist theoretical frameworks and student-centered methodologies. The combination of these approaches, combined within the strong and scholarly-informed social justice lens, reminds us, that the onus of education is to acknowledge, recognise, respect, and engage with the diverse student cohorts, learning needs, and multiple knowledges and cultures that exist in educational contexts. This edited collection creates a holistic discourse around the experiences, interrogations, and innovations occurring within education communities to foreground deeper and more holistic understanding of the intersectionality of diversity and inclusion existing within the contemporary educational settings.

New Horizons in Natural Compound Research provides the latest updates in natural compound research (plant, microbes, algae, fungi) and their novel applications in health, agriculture and environment. The book gives recent advances in the extraction of natural compounds, cutting-edge approaches for natural compound purifications, and emerging trends in natural compound screening and identification. In addition, it provides a detailed explanation of the databases and libraries of natural compounds, as well as their significance. Sections focus on research and multidisciplinary practical techniques of natural product research, encouraging young scientists to pursue unique research while also generating strong research ideas. From a future perspective, this book acts as a guide to identify potential areas and new research opportunities in the field of natural products and their service towards human beings, animals and the environment. - Provides a one–stop solution for concepts, cutting-edge techniques, methods, and novel applications of natural products in health and the environment - Focuses on current gaps in natural product research, as well as methodologies and techniques to assist researchers in resolving existing challenges and speeding up the pace of drug discovery from natural sources - Highlights new avenues of natural product research - Contains contributions from well-experienced researchers from academia, research institutes and top-notch young scientists from industry

This book in the two volume set provides comprehensive coverage on how microbial pathogens can subvert our immune system into responding against self and resulting into autoimmune diseases. In particular, the book covers the different aspects of linking gut microbiota dysbiosis with autoimmune mechanisms involved in disease development to identify future effective approaches based on the gut microbiota for preventing these autoimmune diseases.Contributions in the book focuses on the role of microbiota/probiotics and their distinct mechanisms exerted in management of autoimmune liver, skin, thyroid, rheumatic and myopathic diseases. This could help in better understanding to design therapeutic strategies that can be deployed to prevent these autoimmune diseases.The book has an interdisciplinary appeal and scholars with an interest immunology, medical microbiology and nutritional sciences will value its contribution. Overall, the book gives a new dimensions and insight in the aspects of microbial role in autoimmune disease pathogenesis and therapeutic aspects.

Human Microbiome in Health and Disease, Volume 192, Part B includes chapters surrounding the role of human microbiome in different diseases. Chapters in this comprehensive new volume include The microbiome and communicable diseases, Gut Microbiome and Antimicrobial Resistance in bacterial pathogens, Dysbiosis of human microbiome and infectious disease, Gastrointestinal microbiome in the context of infection in stomach and gastroduodenal diseases, Respiratory tract microbiome and pneumonia, Gut microbiome and neonatal sepsis, Diarrheal disease and gut microbiome, The microbiome and non-communicable diseases, Gut microbiome and inflammatory bowel disease, Gut microbiome and undernutrition, Human microbiome and cardiovascular disease, and much more. - Covers dysbiosis of microbiome in communicable and non-communicable diseases - Discusses the emergence and spread of antimicrobial resistance in gut microbiome - Presents the latest information on reproductive tract microbiome and birth outcomes

This edited collection of 12 chapters by research workers from a wide range of disciplines resolves the confusion that currently surrounds the “hygiene hypothesis” by considering the human need for exposure to microorganisms from an evolutionary point of view. The book explains why we evolved a requirement for exposure to microbiota from our mothers, from other people, and from the natural environment. It also explains the physiological roles of these exposures, what goes wrong when the exposures are distorted and how human lifestyles and activities, including degradation of the natural environment, are leading to this distortion. Particular attention is given to the range of pathologies associated with inappropriate microbial exposures and inappropriate colonization, including immunoregulatory problems such as allergies and autoimmunity, metabolic problems such as obesity and diabetes, and problems of central nervous system function and neurodegeneration. This book is of profound relevance to most medical disciplines, but also to those concerned with preserving the natural environment and with developing healthier urbanisation.

Despite being confined to the gastrointestinal tract, the gut microbiome has a wide impact on human physiology, supplementing its host's biochemistry in a complex symbiotic relationship. Research in the field has evolved rapidly in the last decade, and we are now developing a better understanding of how our gut microbiome can influence our immune systems, metabolism, neurological signaling, and perhaps most unexpectedly, our brains; a phenomenon described as the gut-brain-axis. This book, ‘Handbook of Microbiome and Gut-Brain-Axis in Alzheimer's Disease', sets out to explore the complex role of the microbiome with regard to Alzheimer's disease (AD). The microbiome is a critical and often overlooked aspect of immunity, which in turn plays a role in cognition. The book presents current research into the gut microbiota and its far-reaching impacts on cognitive function and neurodegeneration. Interventions, including probiotic supplementation, fecal transfer, and supplementation with microbial metabolites, are discussed, as is the use of certain probiotics to study the effects of the gut microbiota on behavior and cognitive function, and as potential therapeutics for AD. Other topics covered include the influence of the gut and oral microbiota on immune inflammatory signals: cytokines, neuroendocrine hormones, bacterial components, neuroactive molecules, and microbial metabolites. The book is divided into four sections, each covering a research area pertinent to the gut-brain-axis and its relationship with cognitive function and AD. It will be of interest to all those whose work includes the study and understanding of these complex, multi-variable biological mechanisms, particularly in the context of cognitive function and AD. The cover shows a color edited MRI image of a sagittal section of a neurological control brain of Dr. Giulio Maria Pasinetti.

This book intends to investigate the broad spectrum of genetic changes in immunological processes involved in cutaneous diseases. One of the main goals of immunogenetic studies is finding susceptibility genes for complex diseases. This can provide an insight into the pathogenesis of the condition in a way that is not easily achievable through other kinds of studies. Thus they are a rational initial step for generating hypotheses about disease pathogenesis. This may especially benefit dermatology, a field notorious for having too many diseases with unknown etiologies.Immunogenetic investigations have made targeted treatment strategies possible for diseases such as psoriasis and pemphigus. Even though these strategies have revolutionized the management of chronic dermatological conditions such as psoriasis, still there are a lot of unanswered questions. For instance, psoriasis patients respond very differently to each of the commercially available biological agents. This diversity could be partially explained by the differences in the sets of genes responsible for disease induction in each individual. Thus whole genome sequencing strategies, if feasible at individual levels, might help in tailoring these targeted treatments based on specific genetic backgrounds.Our intention in preparing this book was to explore the broad spectrum of the genetic aspects of immunological processes involved in cutaneous diseases. We have tried to cover most areas of dermatology where enough studies were available to gather a chapter. Still, there is a substantial lack of knowledge on the immunogenetics of many dermatological conditions. We hope that this book would encourage the investigators to fill these gaps of knowledge.

Bringing clarity to the emerging model of precision medicine within the diabetes field, and expanding upon how it will lead to the development of specifically tailored treatment for patients and even macro strategies in public health, this unique book explores the realm of biomarkers in the era of big data. Various experts in their respective areas discuss the current practice to illuminate how creating a more discreet profile of patients and even substratum of populations will lead to more refined therapies targeted towards the phenotype and genotype of the patient.Embracing a multidisciplinary team science approach, this book demonstrates how precision medicine in diabetes can mine a web of data toward diabetes risk stratification and treatment options. The authors skillfully articulate how the construction of various prediction-based models can revolutionize clinical decision-making, and they examine the challenges and pitfalls of integrating disparate sources of information and how the collection of data and cooperation among stakeholders will be key to the future of precision medicine in diabetes treatment. Topics include personalized approaches to the management of both type 1 and type 2 diabetes, various macro and microvascular complications of diabetes, inpatient management of glycemia, nutrition, exercise, advances in diabetes technology and others.Ideal for clinical endocrinologists and other professionals involved in the management of diabetes and its complications, Precision Medicine in Diabetes is first of its kind to address this paradigm-shifting topic in a comprehensive way.

Offering unique, comprehensive coverage of both basic science and clinical scenarios, Clinical Immunology: Principles and Practice, 6th Edition, brings you up to date with every aspect of this fast-changing field. It examines the molecular, cellular, and immunologic bases of immunologic diseases and their broader systemic implications; it also includes complete coverage of common and uncommon immunologic disorders. Updated with all the latest immunologic research and clinical implications, including breakthrough immunotherapies and molecular-based treatment protocols, this fully revised edition provides authoritative guidance from some of the most respected global leaders in immunology in one complete, well-illustrated volume. - Includes extensive revisions that reflect rapidly expanding research and clinical advances, including breakthrough drug and immunotherapies such as immune checkpoint inhibitors, immunotherapies for cancer, precision medicine, and transfusion medicine. - Contains new chapters on COVID-19, immune responses, and the role of the immune system; immunoregulatory deficiencies; immune checkpoints; CAR T cells, including new cellular-based immunotherapy; gene therapy, including CRISPR and gene selection; and a clinically focused chapter on asthma. - Provides new genetics content focused on data applications. - Addresses notable advances in key areas such as the importance of the microbiota to normal immune system development and to the pathogenesis of immunologic and inflammatory diseases; relationships between the innate and adaptive immune systems; progress in rapid and cost-effective genomics; cell signaling pathways and the structure of cell-surface molecules; and many more. - Covers hot topics such as the role of genetics and genomics in immune response and immunologic disease, atherosclerosis, recurrent fever syndromes, aging and deficiencies of innate immunity, the role of microbiota in normal immune system development and in the pathogenesis of immunologic and inflammatory diseases, and novel therapeutics. - Features a user-friendly format with color-coded boxes highlighting critical information on Key Concepts, Clinical Pearls, Clinical Relevance, and Therapeutic Principles. - Summarizes promising research and development anticipated over the next 5–10 years with'On the Horizon'boxes and discussions of translational research. - An eBook version is included with purchase. The eBook allows you to access all of the text, figures and references, with the ability to search, customize your content, make notes and highlights, and have content read aloud.

This book provides a comprehensive resource for clinical hepatology. It details the systematic approach to patients with liver disease in outpatient and inpatient medical settings. A variety of case studies in hepatology including chronic viral hepatitis, and metabolic, autoimmune, and alcohol related liver disease are presented. The book enables the reader to develop a thorough understanding of the clinical presentation, natural history, epidemiology, genetics, and therapeutic options for the liver diseases that clinicians must recognize and manage from the first encounter with the patient through the years of follow up. Clinical Cases in Hepatology systematically describes the approach to a patient with liver disease and is a valuable source for all medical professionals and trainees who care for these patients or are seeking a detailed reference guide to developing their knowledge in the rapidly expanding field of hepatology.

Follow this step-by-step program to optimize your cardiovascular health, boost your energy, slim your waistline, and heat up your sex life—all while enjoying sixty delicious recipes!Cardiovascular disease is America's #1 killer, and while most doctors focus on lowering cholesterol and blood pressure they are overlooking the real culprits: arterial plaque and poor gut health.The good news is that everyone—regardless of size, genetics, gender, or age—can treat arterial plaque, improve their overall health, and prevent heart attacks and strokes with The 30-Day Heart Tune-Up. Inside, you'll discover: A delicious, heart-healthy diet designed to supercharge your heart healthExercises to improve circulation and strengthen your entire cardiovascular systemCreative and effective techniques for stress managementA customized supplement planCutting-edge science on the fascinating ways the bacteria in your gut can affect the health of your heart. This fully revised and updated edition of The 30-Day Heart Tune-Up includes the latest science on the surprising connections between your gut and your heart as well as tons of new information on reducing cardiovascular risk factors like obesity, high blood sugar, high cholesterol, and chronic inflammation through diet and exercise, it will help you get healthy—and stay healthy—for life.

Das intestinale Mikrobiom repräsentiert aktuell eines der Topthemen, die im Fokus der modernen Humanmedizin stehen. Doch erstaunlicherweise gab es bisher im deutschen Sprachraum keine handliche, aktuelle Übersicht zu diesem Thema. Daher werden in diesem Band zunächst Zusammensetzung und Dynamik des humanen intestinalen Mikrobioms erläutert, ehe in weiteren Kapiteln dann die wichtigsten Veränderungen und vor allem die Rolle des Mikrobioms bei zahlreichen Krankheiten wie chronisch entzündlichen Darmerkrankungen, Reizdarmsyndrom, Leber- und Gallenwegs- sowie Autoimmunerkrankungen diskutiert werden. Es folgen der Komplex Ernährung, Adipositas und Diabetes sowie Atherosklerose mit jeweils eigenen Kapiteln. Schließlich gibt es überraschende Beziehungen der Mikrobiota zur Malignomentstehung. Es folgt ein Abschnitt über Antibiotika und deren Rolle bei zum Teil dauerhaften Störungen der intestinalen Bakterien und Pilze. Am Ende des Buches wird am Beispiel von Mikrobiomtransfer (“Stuhltransplantation”) und Probiotika auf die therapeutischen Konsequenzen eingegangen. Alle Kapitel sind auch für sich lesbar und verständlich.

Through 10 outstanding editions, Kelley & Firestein's Textbook of Rheumatology has provided authoritative, in-depth guidance in rheumatology with an ideal balance of basic science and clinical application. The 11th Edition of this classic text continues this tradition of excellence, while keeping you abreast of recent advances in genetics and the microbiome, new therapies such as biologics and biosimilars, and other rapid changes in the field. It provides comprehensive, global coverage of all aspects of diagnosis, screening, and treatment in both adults and children, in a user-friendly, full color reference. - Covers everything from basic science, immunology, anatomy, and physiology to diagnostic tests, procedures, and specific disease processes—including key data on therapeutic outcomes to better inform clinical decision making. - Includes new chapters on Innate Lymphoid Cells and Natural Killer Cells, Pathogenesis of Inflammasome Mediated Diseases, Bisphosphonates, Ultrasound Evaluation of the Musculoskeletal System, and Evaluation of Monoarticular and Polyarticular Arthritis. - Features 1,200 high-quality illustrations, including superb line art, quick-reference tables, and full-color clinical photographs. - Shares the knowledge and expertise of internationally renowned scientists and clinicians, including new editor Dr. Gary Koretzky, specialist in immunology and rheumatology. - Demonstrates the complete musculoskeletal exam in online videos, including abnormal findings and the arthroscopic presentation of diseased joints. - Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices.

The book provides an overview on how the microbiome contributes to human health and disease. The microbiome has also become a burgeoning field of research in medicine, agriculture & environment. The readers will obtain profound knowledge on the connection between intestinal microbiota and immune defense systems, medicine, agriculture & environment. The book may address several researchers, clinicians and scholars working in biomedicine, microbiology and immunology. The application of new technologies has no doubt revolutionized the research initiatives providing new insights into the dynamics of these complex microbial communities and their role in medicine, agriculture & environment shall be more emphasized. Drawing on broad range concepts of disciplines and model systems, this book primarily provides a conceptual framework for understanding these human-microbe, animal-microbe & plant-microbe, interactions while shedding critical light on the scientific challenges that lie ahead.Furthermore this book explains why microbiome research demands a creative and interdisciplinary thinking—the capacity to combine microbiology with human, animal and plant physiology, ecological theory with immunology, and evolutionary perspectives with metabolic science.This book provides an accessible and authoritative guide to the fundamental principles of microbiome science, an exciting and fast-emerging new discipline that is reshaping many aspects of the life sciences. These microbial partners can also drive ecologically important traits, from thermal tolerance to diet in a typical immune system, and have contributed to animal and plant diversification over long evolutionary timescales. Also this book explains why microbiome research presents a more complete picture of the biology of humans and other animals, and how it can deliver novel therapies for human health and new strategies.

Exercise and Sport Pharmacology is an essential book for teaching upper-level undergraduates or entry-level graduate students about how drugs can affect exercise and how exercise can affect the action of drugs. It leads students through the related pathology, exercise physiology, and drug action of many of today's chronically used medications, and discusses how drugs can affect exercise performance.This new second edition of the book is divided into four parts: Section I provides the basics of pharmacology, exercise physiology, autonomic pharmacology, and the stress response; Section II presents chapters on major cardiovascular and respiratory drug classes; Section III describes frequently prescribed medications for such common conditions as diabetes, depression, pain, fever, inflammation, and obesity; and Section IV includes discussions of nutritional supplements and commonly used drugs such as caffeine, nicotine, cannabis, and performance-enhancing drugs. The second edition offers many updates, enhances muscle cell physiology, includes the involvement of the gut microbiome, and each chapter has a new section on the effects of aging.In Sections II and III, chapters include an overview of the pathology that therapeutic drugs are designed to treat and how the drug works in the human body. In contrast to standard pharmacology texts, Exercise and Sport Pharmacology also includes the effect of exercise on the pathology of the condition and the effect of exercise on how the body responds to a drug. Each chapter has a section on whether the drugs under discussion have performance-enhancing potential. Section IV is concerned with self-medication and drugs or supplements taken without a prescription or with limited medical supervision. Throughout, figures and tables as well as data from experiments in exercise pharmacology help to illustrate and summarize content. Each chapter opens with an on-going case example to preview and apply chapter content. In the text, boldface terms indicate which concepts are contained in the book's Glossary. Chapters conclude with a Key Concepts Review and Review Questions.

This volume presents a comprehensive overview of the latest developments in symbiosis research. It covers molecular, organellar, cellular, immunologic, genetic and evolutionary aspects of symbiotic interactions in humans and other model systems. The book also highlights new approaches to interdisciplinary research and therapeutic applications. Symbiosis refers to any mutually beneficial interaction between different organisms. The symbiotic origin of cellular organelles and the exchange of genetic material between hosts and their bacterial and viral symbionts have helped shaped the current diversity of life. Recently, symbiosis has gained a new level of recognition, due to the realization that all organisms function as a holobiome and that any kind of interference with the hosts influences their symbionts and vice versa, and can have profound consequences for the survival of both. For example, in humans, the microbiome, i.e., the entirety of all the microorganisms living in association with the intestines, oral cavity, urogenital system and skin, is partially inherited during pregnancy and influences the maturation and functioning of the human immune system, protects against pathogens and regulates metabolism. Symbionts also regulate cancer development, wound healing, tissue regeneration and stem cell function. The medical applications of this new realization are vast and largely uncharted. The composition and robustness of human symbionts could make them a valuable diagnostic tool for predicting impending diseases, and the manipulation of symbionts could yield new strategies for the treatment of incurable diseases.

Histories of Knowledge in Postwar Scandinavia uses case studies to explore how knowledge circulated in the different public arenas that shaped politics, economics and cultural life in and across postwar Scandinavia, particularly in the 1960s and 1970s.This book focuses on a period when the term'knowledge society'was coined and rapidly found traction. In Scandinavia, society's relationship to rational forms of knowledge became vital to the self-understanding and political ambitions of the era. Taking advantage of contemporary discussions about the circulation, arenas, forms, applications and actors of knowledge, contributors examine various forms of knowledge – economic, environmental, humanistic, religious, political, and sexual – that provide insight into the making and functioning of postwar Scandinavian societies and offer innovative studies that contribute to the development of the history of knowledge at large. The concentration on knowledge rather than the welfare state, the Cold War or the new social and political movements, which to date have attracted the lion's share of scholarly attention, ensures the book makes a historiographical intervention in postwar Scandinavian historiography. Offering a stimulating point of departure for those interested in the history of knowledge and the circulation of knowledge, this is a vital resource for students and scholars of postwar Scandinavia that provides fresh perspectives and new methodologies for exploration.

Biodiversity is among the richest treasures of the earth. Despite their small size, microbes play a vital role in environmental monitoring and making the earth sustainable. Microorganisms preserve and assist plants and animals o either directly or indirectly, and, due to their omnipresence in nature, they inhabit conditions such as extreme temperatures, water, soil, salt, medical wastes, agricultural wastes, and air.Microbes are also important in human culture and play an essential role in existence of life. They are present in food fermentation, sewage treatment, medical, agricultural, and soil waste, antibiotics, soil fertility, model organisms, and human microbiota, aid with decomposition, and are responsible for infectious diseases. This volume represents an important contribution to the field, highlighting the importance of microbial biodiversity to society.

This completely updated and expanded 2nd edition of Systemic Lupus Erythematosus, A Manual includes topics not covered previously with contributors who are at the forefront of each specific topic and with a global appeal. Each chapter is short and is presented critically with selected references, which should be valuable to a wider audience. This book combines basic with clinical science to help internists and specialists in the diagnosis and management of patients with SLE. It is a quick referral for people in the pharmaceutical industry in their efforts to bring much-needed drugs. It provides all the needed information to basic researchers old and new alike, who wish to enter the field of lupus and systemic autoimmunity in general. - Focused state-of-the-art chapters prepared by top-notch experts in the field - Latest understanding of cellular, molecular, biochemical aspects of disease pathogenesis - Advanced aspects of genetic, microbiome, environmental, hormonal, and immunological contribution to the expression of the disease - Current understanding of clinical features of the disease - Recent efforts to develop new treatments

This book systematically reviews the most important findings on cancer immune checkpoints, sharing essential insights into this rapidly evolving yet largely unexplored research topic. The past decade has seen major advances in cancer immune checkpoint therapy, which has demonstrated impressive clinical benefits. The family of checkpoints for mediating cancer immune evasion now includes CTLA-4, PD-1/PD-L1, CD27/CD70, FGL-1/LAG-3, Siglec-15, VISTA (PD-1L)/VSIG3, CD47/SIRPA, APOE/LILRB4, TIGIT, and many others. Despite these strides, most patients do not show lasting remission, and some cancers have been completely resistant to the therapy. The potentially lethal adverse effects of checkpoint blockade represent another major challenge, the mechanisms of which remain poorly understood. Compared to the cancer signaling pathways, such as p53 and Ras, mechanistic studies on immune checkpoint pathways are still in their infancy. To improve the responses to checkpoint blockade therapy and limit the adverse effects, it is essential to understand the molecular regulation of checkpoint molecules in both malignant and healthy cells/tissues. This book begins with an introduction to immune checkpoint therapy and its challenges, and subsequently describes the regulation of checkpoints at different levels. In closing, it discusses recent therapeutic developments based on mechanistic findings, and outlines goals for future translational studies. The book offers a valuable resource for researchers in the cancer immunotherapy field, helping to form a roadmap for checkpoint regulation and develop safer and more effective immunotherapies.

This book provides an authoritative insight on the Loss and Damage discourse by highlighting state-of-the-art research and policy linked to this discourse and articulating its multiple concepts, principles and methods. Written by leading researchers and practitioners, it identifies practical and evidence-based policy options to inform the discourse and climate negotiations.With climate-related risks on the rise and impacts being felt around the globe has come the recognition that climate mitigation and adaptation may not be enough to manage the effects from anthropogenic climate change. This recognition led to the creation of the Warsaw International Mechanism on Loss and Damage in 2013, a climate policy mechanism dedicated to dealing with climate-related effects in highly vulnerable countries that face severe constraints and limits to adaptation. Endorsed in 2015 by the Paris Agreement and effectively considered a third pillar of international climate policy, debate and research on Loss and Damage continues to gain enormous traction. Yet, concepts, methods and tools as well as directions for policy and implementation have remained contested and vague.Suitable for researchers, policy-advisors, practitioners and the interested public, the book furthermore:• discusses the political, legal, economic and institutional dimensions of the issue• highlights normative questions central to the discourse• provides a focus on climate risks and climate risk management.• presents salient case studies from around the world.

For more than 50 years, Dubois'Lupus Erythematosus and Related Syndromes has been recognized internationally as the go-to clinical reference on lupus and other connective tissue diseases. From basic scientific principles to practical points of clinical management, the updated 9th Edition provides extensive, authoritative coverage of systemic lupus erythematosus (SLE) and its related diseases in a logical, clearly written, user-friendly manner. It's an ideal resource for rheumatologists and internal medicine practitioners who need a comprehensive clinical reference on all aspects of SLE, connective tissue diseases, and the antiphospholipid syndromes. - Provides complete clinical coverage of every aspect of cutaneous and systemic lupus erythematosus, including definitions, pathogenesis, autoantibodies, clinical and laboratory features, management, prognosis, and patient education. - Contains an up-to-date overview of significant advances in cellular, molecular, and genetic technologies, including genetic advancements in identifying at-risk patients. - Offers an increased focus on the clinical management of related disorders such as Sjogren's syndrome, scleroderma, polymyositis, and antiphospholipid syndrome (APS). - Presents the knowledge and expertise of more international contributors to provide new global perspectives on manifestations, diagnosis, and treatment. - Features a vibrant, full-color format, with graphs, algorithms, differential diagnosis comparisons, and more schematic diagrams throughout.

The main aim of this volume is to provide an updated overview of the genetic basis of a group of complex disorders that are considered rare individually, but show a relatively high prevalence on the whole in developed countries: the rare autoimmune diseases. These are chronic disorders that involve long and expensive treatments with considerable side effects that may dramatically reduce the quality of life of affected people. Therefore, shedding light into their pathologic mechanisms is a major concern given their growing social and economic awareness and impact. General sections include different chapters on single entities as systemic lupus and sclerosis, Behçet's disease, Sjogren's syndrome and polymiositis, and sections devoted to autoimmune vasculitis, hepatic autoimmune conditions, as well as those affecting the nervous system, and a concluding chapter in which the shared predisposition amongst all diseases is discussed. All the chapters are given a homogeneous scheme in which the authors explain the clinical singularities of every disease and report the recent breakthrough discoveries related to them, giving a critical interpretation and suggesting future perspectives. All contributors are renowned researchers with high expertise in each disease. Due to the exponential increase in our understanding of the genetic causes of these complex diseases, a major advance in biomedical discovery is taking place. However, most of the achievements in this field are very recent and there is a lack of bibliography gathering them together. This book is thus filling a gap and will prove a useful companion to clinicians in the first place (internists, rheumatologists, clinical immunologists, and hematologists) but also to basic and applied researchers.

Celebrating 100 years of HEP, this volume will discuss key pharmacological discoveries and concepts of the past 100 years. These discoveries have dramatically changed the medical treatment paradigms of many diseases and these concepts have and will continue to shape discovery of new medicinies. Newly evolving technologies will similarly be discussed as they will shape the future of the pharmacology and, accordingly, medical therapy.

This book introduces many new technologies and clinical applications of hematopoietic stem cells and mesenchymal stem cell transplantation for the treatment of autoimmune diseases and inflammatory diseases. Presented in two parts, Part 1 focuses on stem cell therapies for autoimmune disease treatment; Part 2 focuses on stem cell therapies and their application in the treatment of common inflammatory diseases, including chronic knee osteoarthritis, chronic obstructive pulmonary disease, liver cirrhosis, Crohn's Disease, Multiple Sclerosis, and more. This book is an essential source for all advanced students and researchers involved with these diseases, stem cells, or both. Stem Cell Transplantation for Autoimmune Diseases and Inflammation and the other books in the Stem Cells in Clinical Applications series are invaluable to scientists, researchers, advanced students and clinicians working in stem cells, regenerative medicine, or tissue engineering as well as cancer or genetics research.

This volume discusses emerging contexts of agricultural and ecosystem resilience in Sub Saharan Africa, as well as contemporary technological advances that have influenced African livelihoods. In six sections, the book addresses the sustainable development goals to mitigate the negative impacts on agricultural productivity brought about by climate change in Africa. Some of the challenges assessed include soil degradation, land use changes, natural resource mismanagement, declining crop productivity, and economic stagnation. This book will be of interest to researchers, NGOs, and development organizations.Section 1 focuses on climate risk management in tropical Africa. Section 2 addresses the water-ecosystem-agriculture nexus, and identifies the best strategies for sustainable water use. Section 3 introduces Information Communication Technology (ICT), and how it can be used for ecosystem and human resilience to improve quality of life in communities. Section 4 discusses the science and policies of transformative agriculture, including challenges facing crop production and management. Section 5 addresses landscape processes, human security, and governance of agro-ecosystems. Section 6 concludes the book with chapters uniquely covering the gender dynamics of agricultural, ecosystem, and livelihood resilience.