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Organoselenium Chemistry is a unique resource in this branch of organic/organometallic chemistry. The authors give an overview of synthesis strategies, introduce bioactive and environmentally friendly organoselenium compounds and discuss their applications from organic synthesis to the clinic.

This book presents recent advances in and perspectives on the use of organoselenium compounds, primarily highlighting the new frontiers in the field of Green Chemistry, their therapeutic and biological relevance and new materials. Throughout its 200 pages, readers will find an updated and comprehensive review of new aspects of organoselenium chemistry and biochemistry. Fully referenced and written in an easy to read style, it offers readers a primary resource for including organoselenium derivatives in their projects. This book will be of interest to specialists, students and researchers involved in a broad range of fields, from synthetic green chemistry to medicinal chemistry and the chemistry of natural products. The connection between organoselenium compounds and green chemistry, despite having only recently emerged, is one of the subjects of this book. The first chapter highlights the use of Se-containing molecules as reagents and catalysts in new green protocols to access important organic transformations. The book provides a wealth of examples of bioactive Se-containing molecules, especially focusing on those with potential therapeutic uses. The second chapter focuses on the state of the art concerning the role of organoselenium compounds as antioxidants, GPx mimics, and derivatives endowed with different bioactive properties. “Organoselenium in nature” is the title of the third chapter, which equips readers with essential information on the main natural organoselenium compounds and where they are found. Selected aspects of the metabolism of selenium in plants and microorganisms are also discussed. In closing, the book includes a chapter dedicated to recent advances concerning the nonbonding interactions between organochalcogen compounds. This is currently a hot topic in selenium chemistry and biochemistry, and here readers will find key insights into the chalcogen bond and its role in the biological activity of organoselenium compounds.

Organoselenium shows incredible promise in medicine, particularly cancer therapy. This book discusses organoselenium chemistry and biology in the context of its therapeutic potential, taking the reader through synthetic techniques, bioactivity and therapeutic applications. Divided into three sections, the first section describes synthetic advances in bioactive selenium compounds, revealing how organoselenium compound toxicity, redox properties and specificity can be further tuned. The second section explains the biophysics and biochemistry of organoselenium compounds, as well as selenoproteins. The final section closes with several chapters devoted to therapeutic and medicinal applications of organoselenium compounds, covering radioprotectors, anticancer agents and antioxidant behaviour. With contributions from leading global experts, this book covers recent advances in the field and is an ideal reference for those researching organoselenium compounds.

The use of organoselenium reagents as catalysts is a common thread that runs through the chapters of this book, introducing important aspects of the modern organoselenium chemistry: organocatalysis, green chemistry, bioinspiration, antioxidant activity. The eBook covers the most recent developments in the classical synthetic application of organoselenium reagents such as electrophilic, nucleophilic and free radical reagents. The volume also features a discussion on the synthesis and the synthetic applications of some emerging classes of selenium compounds such as hypervalent selenium species and selenoamides, and also addresses some biological aspects such as the antimicrobial activity of organoselenium derivatives and the biochemistry of selenoproteins. A number of eminent scientists from different research groups were involved in the preparation of the 13 chapters of the book, making Organoselenium Chemistry: Between Synthesis and Biochemistry an excellent reference about selenium chemistry for researchers and graduate students in the field of selenium chemistry.

In his thesis, Sohail Shahzad carefully investigates carbon nucleophiles in selenocyclisations, as well as reaction protocols for performing such reactions catalytically. After a comprehensive introduction to the element selenium, the author goes on to report the synthesis of several substrates for carbocyclisation reactions and the use of selenium reagents for the preparation of dihydronaphthalenes. Further chapters detail electrophilic selenium-mediated reactions, and novel strategies using selenium catalysts together with stoichiometric amounts of hypervalent iodine reagents as oxidants to convert stilbene carbosylic acids into the corresponding isocoumarins. This thesis outlines some excellent new synthetic routes which will be useful tools for synthetic organic chemistry in the future.

Selenium-based methods in synthetic chemistry have developed rapidly over the past years and are now offering highly useful tools for organic synthesis. Filling the gap for a comprehensive handbook and ready reference, this book covers all modern developments within the field, including biochemical aspects. The chemistry chapters are organized according to the different reactivities of various selenium compounds and reagents, with each chapter dealing with a special reaction type. Also includes a table with 77Se NMR shifts to aid in practical problems. From the Contents: • Electrophilic and Nucleophilic Selenium • Selenium Compounds in Radical Reactions • Selenium-Stabilized Carbanions • Selenium Compounds with Valency Higher than Two • Selenocarbonyls • Selenoxide Elimination and [2,3]-Sigmatropic Rearrangement • Selenium Compounds as Ligands and Catalysts • Biological and Biochemical Aspects of Selenium Compounds

Specialist Periodical Reports provide systematic and detailed review coverage of progress in the major areas of chemical research. Written by experts in their specialist fields the series creates a unique service for the active research chemist, supplying regular critical in-depth accounts of progress in particular areas of chemistry. For over 80 years the Royal Society of Chemistry and its predecessor, the Chemical Society, have been publishing reports charting developments in chemistry, which originally took the form of Annual Reports. However, by 1967 the whole spectrum of chemistry could no longer be contained within one volume and the series Specialist Periodical Reports was born. The Annual Reports themselves still existed but were divided into two, and subsequently three, volumes covering Inorganic, Organic and Physical Chemistry. For more general coverage of the highlights in chemistry they remain a'must'. Since that time the SPR series has altered according to the fluctuating degree of activity in various fields of chemistry. Some titles have remained unchanged, while others have altered their emphasis along with their titles; some have been combined under a new name whereas others have had to be discontinued. The current list of Specialist Periodical Reports can be seen on the inside flap of this volume.

Specialist Periodical Reports provide systematic and detailed review coverage of progress in the major areas of chemical research. Written by experts in their specialist fields the series creates a unique service for the active research chemist, supplying regular critical in-depth accounts of progress in particular areas of chemistry. For over 80 years the Royal Society of Chemistry and its predecessor, the Chemical Society, have been publishing reports charting developments in chemistry, which originally took the form of Annual Reports. However, by 1967 the whole spectrum of chemistry could no longer be contained within one volume and the series Specialist Periodical Reports was born. The Annual Reports themselves still existed but were divided into two, and subsequently three, volumes covering Inorganic, Organic and Physical Chemistry. For more general coverage of the highlights in chemistry they remain a'must'. Since that time the SPR series has altered according to the fluctuating degree of activity in various fields of chemistry. Some titles have remained unchanged, while others have altered their emphasis along with their titles; some have been combined under a new name whereas others have had to be discontinued. The current list of Specialist Periodical Reports can be seen on the inside flap of this volume.

Specialist Periodical Reports provide systematic and detailed review coverage of progress in the major areas of chemical research. Written by experts in their specialist fields the series creates a unique service for the active research chemist, supplying regular critical in-depth accounts of progress in particular areas of chemistry. For over 80 years the Royal Society of Chemistry and its predecessor, the Chemical Society, have been publishing reports charting developments in chemistry, which originally took the form of Annual Reports. However, by 1967 the whole spectrum of chemistry could no longer be contained within one volume and the series Specialist Periodical Reports was born. The Annual Reports themselves still existed but were divided into two, and subsequently three, volumes covering Inorganic, Organic and Physical Chemistry. For more general coverage of the highlights in chemistry they remain a'must'. Since that time the SPR series has altered according to the fluctuating degree of activity in various fields of chemistry. Some titles have remained unchanged, while others have altered their emphasis along with their titles; some have been combined under a new name whereas others have had to be discontinued. The current list of Specialist Periodical Reports can be seen on the inside flap of this volume.

The explosive growth of organoselenium chemistry over the past 12 years can be attributed to the specific properties of organic selenium molecules, which fit the requirements of modern organic synthesis. Most of them are well adapted to chemo-, regio- and stereo-selectivities. In addition, they can be used in mild experimental conditions which are compatible with the stability of both substrates and products in the preparation of unsaturated and functional complex molecules, especially in the field of natural products. This book describes and illustrates different synthetic routes to organic structures using selenium reagents or intermediates. The approach emphasizes that such transformations are simple, efficient and often carried out at room temperature. The scope ranges from the preparation of both inorganic and organic selenium reagents, through descriptions of structure, toxicity, biological aspects and nuclear magnetic resonance, to applications of specific selenium compounds in various syntheses including natural products and biologically active compounds.