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This is an exhaustive reference volume to the thousands of songs, songwriters and performers in 1,460 American and British films (musical and nonmusical) since the advent of the talkie in 1928. Listed alphabetically by film title, each entry provides full production information on the movie, including the country of origin, year of release, running time, director, musical director, musical score, studio, producer, orchestra or bands featured, music backup, vocalist, (dubber who sang on the soundtrack), and performers. Each song title in the main entry is followed by the name of the performer, lyricist, composer, and, when appropriate, arranger.

This book is a comprehensive review of the recent research on the lipotoxicity-related mechanisms in obesity and the development of new treatment strategies. In this second edition, the possible molecular treatment methods and their recent clinical approaches are discussed in addition to the basic mechanisms that are available and thoroughly reviewed previously. Moreover, all chapters have been reviewed, according to the current concepts and seven new chapters are added, covering obesity-related epigenetic modifications, senescence, obesity-related cancer development, endocrine disruptors, as well as nanotechnology-based clinical approaches. This book is an essential resource for clinicians and basic science researchers, such as biochemists, toxicologists, immunologists, nutritionists, adult and pediatric endocrinologists, and cardiologists, as well as all researchers or students who want to learn the mysteries of obesity.

Nel centenario dell'attore e autore, nato l'8 marzo 1924, esce la prima completa biografia di Walter Chiari, firmata da Michele Sancisi con la collaborazione del figlio di Chiari, Simone Annicchiarico. Questo libro, ricchissimo di testimonianze e documenti inediti, raccoglie aneddoti sorprendenti e spassosi, facendo al contempo luce su alcuni passaggi controversi della sua vita. Nato a Verona da un'umile famiglia pugliese e diventato milanese negli anni Trenta, si è affermato come re della rivista, per poi esordire nel cinema, dove ha interpretato più di cento film. Dagli anni Cinquanta è stato un popolare volto della Tv in storiche trasmissioni come Canzonissima e Studio Uno. Ha battuto per decenni record d'incassi del teatro brillante e riempito le pagine della stampa patinata con innumerevoli avventure sentimentali. Campione di stile ed eleganza italiani, Chiari ha vissuto 67 anni a cento all'ora. Tra queste pagine, che accostano il calore e l'intimità dello sguardo familiare al profondo rigore documentaristico, scopriamo anche un uomo timido e romantico, segnato da lati oscuri e dipendenze, al centro di clamorosi episodi giudiziari che ne hanno minato la fama. Un uomo che nonostante tutto ha saputo risollevarsi e tornare sulla cresta dell'onda, grazie all'amore del suo pubblico e a un talento destinato a giungere intatto fino a noi. Walter Chiari era la dimostrazione che si può stare con i piedi per terra e la mente sulla traiettoria stellare di Peter Pan. Lui era la possibilità dell'incredibile, in cui si può, si deve credere. Era la via traversa che non ti viene insegnata né consigliata. Era un dolcissimo cattivo maestro, in un'epoca che si stava popolando di orribili cattivi maestri. MICHELE SANCISI Tanti ricordi che ho scelto a caso, sull'onda delle mie sensazioni, del mio affetto. Ricordi che magari fanno ridere solo me, ma l'unica è provarci, provare a trasmettere, per iscritto, ciò che davvero è intrasmissibile. Walter non era solo un uomo in carne e ossa, ma anche un fumetto, un'idea, era Errol Flynn mischiato a Jacques Couste

This textbook has been designed to give the readers a comprehensive overview of all these aspects of diabetes, starting from the basics its complications as well as comorbidities, followed by management strategies by means of chapters, wellillustrated with numerous figures and tables and supported by latest scientific evidence in a ‘standard medical textbook format'. The text has been segregated into sections with related subtopics in each section to make it well organized and reader friendly.

This book offers a comprehensive overview of the most important neurochemicals and approaches everything from the neurochemical's perspective. It attempts to integrate the biochemical pathways of synthesis and metabolism of these neurochemicals with the disease states and point out the avenues of diagnostic testing and therapeutic intervention. Each chapter focuses on a specific neurochemical and provides a brief history, the biochemical profile, metabolism, physiological functions, and the clinical aspects. The clinical part of each chapter includes a discussion on disease states with either increased or reduced activity of the neurochemical and either activation or inhibition of the relevant receptors. This book is targeted toward practitioners and students of neuroscience and is written to emphasize the importance of these neurochemicals in the brain. With this emphasis on background neurochemical processes, the readers will be pointed towards logical diagnostic studies, laboratory investigations, and therapies based on the neurochemical dysfunction that underlies various disease states.

Redox Chemistry and Biology of Thiols offers an applied, comprehensive overview of redox chemistry and biology of thiol-dependent processes. Running from basic biology and chemistry of redox phenomena to research methods and highlighting recently identified roles of thiols across cellular and bodily systems, this book draws upon a range of disciplines to illuminate new research directions, new applications of thiol studies, and clinical translation. Sections cover thiol oxidizing species, thiol reactivity and modifications, thioredoxin, glutaredoxin, glutathione, peroxidases, thiol repair enzymes, thiol oxidative signaling, disulfide bond formation, thiol-based redox biosensors, cysteine and hydrogen sulfide metabolism, iron-sulfur cluster biogenesis, thiols in chloroplasts, blood thiols, sugar and polyamine thiols in pathogenic organisms, redox medicine (therapeutic applications of thiols and drug development), as well as methods and bioinformatics tools. - Runs from basic thiol biology and chemistry to applications and clinical translation - Provides methods and protocols that will power new research across biomedicine, cell biology, plant biology, drug development, and protein folding and modulation - Includes chapter contributions from international leaders in the field

This book analyses the factors that influence the development and implementation of Health Technology Assessment (HTA) from multiple perspectives. It investigates the development of HTA activities in decentralized countries with a specific focus on the analysis of healthcare professionals'perceptions. Although these perceptions are highly relevant in terms of implementing HTA processes, especially at the local level, they are rarely captured, and require further investigation, which this book provides. In particular, HTA has been introduced as a support tool for reviewing and assessing the introduction and dissemination of healthcare technologies. The book discusses how individual and organisational factors affect knowledge production and translation, and their relevance in the context of HTA. Furthermore, it explores how HTA could be more successfully implemented in decentralized healthcare systems.

Dieses Buch bietet erstmals eine länderübergreifende und umfassende Darstellung der technischen und historischen Entwicklung des Fahrrads von den frühesten Laufmaschinen als Reitpferdersatz bis hin zu modernen Rennrädern, Mountainbikes und Liegerädern. Es zeichnet die Entwicklung des Fahrrads auch anhand der einzelnen Komponenten wie Antrieben, Schaltungen, Federungen, Bremsen, Lichtanlagen, Speichenrädern und Luftreifen nach, die von Erfindern und Herstellern hinsichtlich Material, Ergonomie und Fahrphysik zuwege gebracht wurden. Mit vielen Original- und Patentgrafiken sowie dem ausgewählten Literaturverzeichnis stellt dieses Buch den Ausgangspunkt für alle künftigen Recherchen dar.

This book aims to provide a state-of-the-art summary of what is currently known about brain glycogen metabolism, detailing the recent advances in our understanding of why glycogen is so critical for normal brain function. The role of glycogen in cellular neurophysiology remains largely unclear and its specific contribution to the energy demand of brain cells is still elusive.Glycogen is the sole cerebral glucose reserve and is emerging as a fundamental component of brain energy metabolism. Pharmacological or genetic manipulation of glycogen metabolism in the brain impairs memory formation and increases susceptibility to epileptic seizures and cortical spreading depression. Glycogen is also directly implicated in abnormal neuronal excitability and mental retardation that characterize brain disorders like Lafora disease and Pompe disease.

The main focus of this book is on brown adipose tissue and its metabolic function. The book provides a timely update on the latest research and shows where the field is heading. Brown adipose tissue (BAT) dissipates energy and has received considerable attention in the last few years, having been re-discovered in adult humans in 2007/9. Moreover, BAT might offer a target for novel therapies to address obesity, a health condition that has reached pandemic dimensions.

This volume focuses on blocking disease transmission and the ecological perspective of pathogens and pathogenic processes. The chapters on blocking transmission cover the environmental safety of space flight, biocides and biocide resistance, as well as infection control in healthcare facilities. The book also offers insights into the ecological aspects of infectious disease, introducing the reader to the role of indigenous gut microbiota in maintaining human health and current discussions on environmentally encountered bacterial and fungal pathogens including species that variously cause the necrotizing skin disease Buruli ulcer and coccidioidomycosis. Further, it explores the influenza A virus as an example for understanding zoonosis. It is a valuable resource for microbiologists and biomedical scientists alike.

Ion channels are the major class of membrane proteins responsible for rapid and regulated transport of ions across biological membranes and for the generation and propagation of electrical signals in the brain, heart, and skeletal and vascular tissues. Ion channels are also known to play critical roles in regulation of cell proliferation, insulin secretion and intracellular signaling in a variety of cell types. This book focuses on the roles of ion channels in vascular tissues under normal and pathological conditions. Vascular abnormalities are known to underlie a plethora of severe pathological conditions, such as atherosclerosis, systemic and pulmonary hypertension, coronary or cerebral vasospasm, and diabetes. In addition, misregulated angiogenesis is one of the major contributors to the development of tumors. Therefore, it is clearly imperative to obtain a better understanding of the molecular mechanisms that contribute to vascular disorders. This book will be the firstcomprehensive assembly of assays to present the studies that have been done during the last decade to elucidate the roles of ion channels in different vascular diseases.

This book provides a comprehensive review of new agents, a detailed description of new uses of current agents, and an integration of the available agents in clinical practice. A description of a detailed clinical approach provides clinical practitioners with the most up-to-date recommendations for the prevention and treatment of chemotherapy-induced nausea and vomiting (CINV) in various clinical settings.CINV is one of the most feared treatment related toxicities. Patient surveys for the past thirty years consistently demonstrate patients'perception of deterioration in quality of life due to chemotherapy treatments. The introduction of the antiemetics, serotonin 5-HT3 receptor antagonists and the neurokinin-1 receptor antagonists, have improved the control of chemotherapy-induced emesis, but the treatment of chemotherapy-induced nausea remains a significant clinical problem. Patients continue to have quality of life issues which prevent normal functioning during active treatment. New agents such as the second generation 5-HT3 receptor antagonist palonosetron and the new neuroknin-1 receptor antagonists rolapitant and netupitant are being introduced into clinical practice, and it is anticipated that these new agents will improve the control of CINV. Agents such as olanzapine (a FDA approved anti-psychotic), gabapentin (a FDA approved neuroleptic), and ginger (a food additive), which have been used primarily for other indications, are now being tested as potential, effective antiemetics. This work represents the first available comprehensive summary that details all new antiemetic agents and, particularly, their clinical role in treating patients; an important reference for practitioners seeking to improve the quality of life of patients undergoing chemotherapy.

Epilepsy is a devastating group of neurological disorders characterized by periodic and unpredictable seizure activity in the brain. There is a critical need for new drugs and approaches given than at least one-third of all epilepsy patients are not made free of seizures by existing medications and become'medically refractory'. Much of epilepsy research has focused on neuronal therapeutic targets, but current antiepileptic drugs often cause severe cognitive, developmental, and behavioral side effects. Recent findings indicate a critical contribution of astrocytes, star-shaped glial cells in the brain, to neuronal and network excitability and seizure activity. Furthermore, many important cellular and molecular changes occur in astrocytes in epileptic tissue in both humans and animal models of epilepsy. The goal of Astrocytes and Epilepsy is to comprehensively review exciting findings linking changes in astrocytes to functional changes responsible for epilepsy for the first time in book format. These insights into astrocyte contribution to seizure susceptibility indicate that astrocytes may represent an important new therapeutic target in the control of epilepsy. Astrocytes and Epilepsy includes background explanatory text on astrocyte morphology and physiology, epilepsy models and syndromes, and evidence from both human tissue studies and animal models linking functional changes in astrocytes to epilepsy. Beautifully labelled diagrams are presented and relevant figures from the literature are reproduced to elucidate key findings and concepts in this rapidly emerging field. Astrocytes and Epilepsy is written for neuroscientists, epilepsy researchers, astrocyte investigators as well as neurologists and other specialists caring for patients with epilepsy. - Presents the first comprehensive book to synthesize historical and recent research on astrocytes and epilepsy into one coherent volume - Provides a great resource on the field of astrocyte biology and astrocyte-neuron interactions - Details potential therapeutic targets, including chapters on gap junctions, water and potassium channels, glutamate and adenosine metabolism, and inflammation

The 41st edition of this established reference work offers a wealth of information on the worldwide publishing landscape. It includes more than 1,100,000 publishers'ISBN prefixes from 221 countries and territories. The Geographical Section (volumes 1-5) provides the names of more than 1,000,000 active publishing houses, arranged alphabetically by country, and within country by name. Entries contain the full address including email and URL particulars as well as ISBN prefixes. Publishers can be identified via their ISBN prefixes through the Numerical ISBN Section (volumes 6-7). The eBookPLUS format comprises the content and search criteria of the printed edition and its indices, facilitating complex searches.

This volume is intended for neuropharmacologists, psychopharmacologists, pharmacologists, pharmacists, sleep researchers, translational neuroscience researchers, and other basic researchers and clinical scientists interested in an interdisciplinary approach to sleep medicine. The level of the book is aiming at CNS researchers, drug development scientists, basic and clinical sleep researchers, as well as senior medical students and fellows in psychiatry and neurology. Orexin and Sleep provides a unique resource, giving a comprehensive and highly readable summary of the basic concepts in orexin biology and pharmacology along with clinical applications in sleep medicine in general, and narcolepsy in particular.

Le style'chronique'a vu le jour entre le Tigre et l'Euphrate, il y a des millénaires. C'est un genre d'ouvrage qui mémorise différents événements caractéristiques de domaines particuliers, classés suivant l'ordre du temps. Il s'agit d'un outil de confrontation et de travail, dont on a besoin de temps à autre, comme on se sert d'une grammaire ou d'un dictionnaire. Cet ouvrage mentionne les oeuvres de création visuelle les plus marquantes de notre société occidentale depuis deux mille ans, principalement dans un pentagone délimité par Londres, Copenhague, Vienne, Rome et Madrid. On y aborde des disciplines souvent négligées comme l'écriture typographique, ce qui rend cet ouvrage sans précédent. De la lampe au logotype, de l'architecture à la peinture et à la sculpture, du croquis aux productions cinématographiques, en passant par l'Opéra... Puisse le lecteur avide de comprendre, de comparer, de confronter, de cerner, de synthétiser une évolution, un style, une école, un créateur ou un créatif, y trouver réponse à ses questions. Il ne manquera pas ensuite d'éprouver une véritable faim et n'aura de cesse de se plonger et de se replonger dans ces 1787 entrées (qui se renvoient les unes aux autres), dans ce qui pourrait bien s'avérer être une tentative réussie de'somme'. Cet ouvrage est la reprise complétée, en français, de Kroniek van de vorm que l'auteur a édité, en néerlandais, en 1997.

El libro hace especial hincapié en los dos aspectos fundamentales de la gestión sanitaria de forma integral, el de eficiencia y control de costes bajo nuevas herramientas de gestión como son los sistemas de ajuste de riesgos refinados, ampliamente descritos en tres de los capítulos del libro (Capítulos 10, 29 y30); y el de gestión continua de la calidad, enfocada hacia la mejora de la calidad del sistema sanitario, también a lo largo de varios capítulos del libro. La mejora de la calidad del sistema sanitario en su conjunto debe presidir las actuaciones de las instituciones sanitarias públicas y privadas, por lo queéste es un libro de lectura recomen-dada para todos los agentes participantesen la asistencia sanitaria, y de manera especial para aquellos involucrados directamente con la gestión, bien a nivel de cuadros de mando directivos y asistenciales como de todos aquellos profesionales de la sanidad, que constituyenun elemento esencial en la modernización y calidad del sistema sanitario español en su con-junto, involucrados o con ansias de participar en el nuevo cambiode paradigma de la gestión clínica. Otro de los elementos esenciales para elfuncionamiento cohesionado y con garantías de calidad del Sistema Nacional deSalud, es la existencia de un verdadero sistema de información sanitaria que garantice la disponibilidad de la información y la comunicación recí-procas entre la Administración sanitaria del Estado y la de las comunidades autónomas, ysirva de punto de partida para la confección de protocolos clínicos y de Guías Integradas Asistenciales, y que posibilite la realización de un efectivo bench-marking. En este aspecto el libro aporta y describe también ampliamente envarios capítulos la importancia de los indicado-res tanto de actividad como decalidad asistencial con un enfoque final hacia la gestión clínica y el gobierno clínico, aspectos estos ampliamente descritos a lo largo de varios capítulos. En conclusión, creo que se trata de una obra de gran interés en el campo del mundo de la gestión sanitaria, esencial y de obligada lectura en aras de unfuncionamiento cohesionado y con garantías de calidad, y muy útil como guión yreferencia para poder introducir aquellas reformas necesarias que nos permitan reforzar la sostenibilidad, mejorar la eficiencia en la gestión, promover elahorro y las economías de escala, e introducir nuevas herramientas a través de las nuevas tecnologías con criterios de racionalización y eficiencia en la gestión, que permitan además una mayor homogeneización y estandarización del proceso, tanto en la gestión de estructuras sanitarias como en la clínica diaria.INDICE RESUMIDO: Sistemas sanitarios y reformas sanitarias. Carácterísticas delos modelos sanitarios. La Ley 17/2003 de Cohesión y Calidad del Sistema Nacional de Salud. La Ley 41/2002, de 14 de Noviembre, básica de Autonomía del Paciente, como herramienta normativa de mejora de la calidad asistencial. Indicadores de actividad de las organizaciones sanitarias. Calidad y bioética en lasorganizaciones sanitarias. Normativa ética y de calidad de la investigación biomédica. Desarrollo de un programa de calidad en Atención Primaria. Mejora dela calidad asistencial mediante la telemedicina y la teleasistencia, etc

A l'heure où les archives de l'Etat Indépendant du Congo (1885-1908) commencent à être accessibles, l'auteur se propose de revenir sur certains aspects de l'histoire de ce singulier'non-pays'. Région abandonnée de façon irréfléchie par les grandes puissances coloniales à Leopold II, roi des Belges, l'Etat Indépendant du Congo va rapidement se montrer beaucoup plus intéressant qu'il n'y paraissait...

A record of the role of selected middle-class individuals across Europe who made notable contributions to the early evolution of modern sport and who saw success in modern sport as an expression of human qualities to be admired, applauded and encouraged. They viewed sport, sometimes self-interestedly but not always self-interestedly, as a medium of personal, collective and national virtue. It is the first general consideration of a selection of these innovatory pioneers and proselytisers who placed Europe at the forefront of major developments in contemporary world sport - now a phenomenon of global significance.

Vitamin A (retinol) is an essential dietary compound with myriad metabolic and regulatory functions. Deficiency can result in vision problems, compromised immune responses, and a host of other medical issues. More than 600 carotenoids have been identified in plants, algae, fungi, and bacteria, and around 50 carotenoids-includingcarotene-can be co

This volume explores the art of coachbuilding from its roots in the late nineteenth century through to the inevitable decline that set in during the 1950's. This definitive work explores both the great names and the forgotten innovators of the industry with the detailed entries and generous illustrations that have won the Encyclopedia of the Automobile critical raves and legions of fans on both sides of the Atlantic.

This book will describe the nuclear encoded genes and their expressed proteins of mitochondrial oxidative phosphorylation. Most of these genes occur in eukaryotic cells, but not in bacteria or archaea. The main function of mitochondria, the synthesis of ATP, is performed at subunits of proton pumps (complexes I, III, IV and V), which are encoded on mitochondrial DNA. The nuclear encoded subunits have mostly a regulatory function. However, the specific physiological functions of the nuclear encoded subunits of complexes I, III, IV, and V are mostly unknown. New data indicates that they are essential for life of higher organisms, which is characterized by an adult life without cell division (postmeiotic stage) in most tissues, after the juvenile growth. For complex IV (cytochrome c oxidase) some of these subunits occur in tissue-specific (subunits IV, VIa, VIb, VIIa, VIII), developmental-specific (subunits IV, VIa, and VIIa) as well as species-specific isoforms. Defective genes of some subunits were shown to induce mitochondrial diseases. Mitochondrial genes and human diseases will also be covered.

A comprehensive look at current drug discovery and development methods—and the roadmap for the future Providing both understanding and guidance in characterizing potential drugs and their production and synthesis, Development of Therapeutic Agents Handbook gives professionals a basic tool to facilitate research and development within this challenging process. This comprehensive text brings together, in one resource, a compendium of concepts, approaches, methodologies, and limitations that need to be considered in the formulation of therapeutic agents across a range of therapeutic fields. Both a reference and a call to action for the pharmaceutical industry, Development of Therapeutic Agents Handbook examines recent innovations taking shape in the various medical disciplines involved in drug discovery, and shows why these advances need to be embraced universally among researchers to improve their solution strategies. Additional subject matter includes: Extensive coverage and in-depth look into novel treatments and therapeutics Discussion of hot topics like new drugs and nutraceuticals, the discovery and development of vaccines, cancer therapeutics, and market overviews Coverage of therapeutic drug development for specific disease areas, such as cardiology, oncology, breast cancer, and kidney diseases As research in biology, chemistry, medicine, and technology rapidly progresses, it is becoming increasingly important for medical researchers to maintain an up-to-date knowledge base of emerging trends directing promising new therapies. Development of Therapeutic Agents Handbook serves this purpose, acting as both a one-stop reference rich in valid science, and a tool to carve out new pathways in the pursuit of bringing safer and more effective drugs to the marketplace.

La volonté de synthèse a présidé à la Chronique de la forme et dévoile combien l'ensemble des différents champs thématiques cernés est riche en interactions. Les traités, manifestes et ouvrages de référence de l'histoire de l'art (plus de 600) dont l'influence s'est confirmée au fil des ans, sont cités dans l'ordre chronologique. Les noms de personnes, titres de films, de livres, de pièces de théâtre et autres informations similaires sont mentionnés en leur totalité, selon l'orthographe d'origine, s'affichent en caractères italiques. En plus des abréviations dans les colonnes, l'index offre des clefs supplémentaires. Par exemple, sous l'entrée « revue », il donne accès à plus de 200 revues importantes. On y trouve également certaines oeuvres capitales (par exemple « Sixtine, chapelle ») ou des mouvements d'art très influents, comme Arts and Crafts, De Stijl ; des écoles comme le Bauhaus...

This book presents current research in the study of ghrelin, a gastric peptide hormone and neurotransmitter, which has been identified in the hypothalamus of the central nervous system, and has importance in food intake, body-weight regulation and glucose homeostasis. Topics discussed in this compilation include the pro-ghrelin derived peptides in iris muscle regulation and their implication in glaucoma pathophysiology; the expression, mechanisms of activity and role of ghrelin in the development of brain and neuronal networks; the role of central ghrelin in gastric accommodation and reflex swallowing and physiological relevances of ghrelin synthesis, transport and degradation.

In the first 20 years that followed the purinergic signalling hypothesis in 1972, most scientists were sceptical about its validity, largely because ATP was so well established as an intracellular molecule involved in cell biochemistry and it seemed unlikely that such a ubiquitous molecule would act as an extracellular signalling molecule. However, after the receptors for ATP and adenosine were cloned and characterized in the early 1990s and ATP was established as a synaptic transmitter in the brain and sympathetic ganglia, the tide turned. More recently it has become clear that ATP is involved in long-term (trophic) signalling in cell proliferation, differentiation and death, in development and regeneration, as well as in short-term signalling in neurotransmission and secretion. Also, important papers have been published showing the molecular structure of P2X receptors in primitive animals like Amoeba and Schistosoma, as well as green algae. This has led to the recognition of the widespread nature of the purinergic signalling system in most cell types and to a rapid expansion of the field, including studies of the pathophysiology as well as physiology and exploration of the therapeutic potential of purinergic agents.In two books, Geoffrey Burnstock and Alexej Verkhratsky have aimed at drawing together the massive and diverse body of literature on purinergic signalling. The topic of this first book is purinergic signalling in the peripheral and central nervous systems and in the individual senses. In a second book the authors focus on purinergic signalling in non-excitable cells, including those of the airways, kidney, pancreas, endocrine glands and blood vessels. Diseases related to these systems are also considered.

Cornea, edited by Drs. Krachmer, Mannis & Holland, is the only truly comprehensive clinical reference available that covers external disease, anterior uveitis, and the expanding range of contemporary corneal surgery. In this Third Edition, state-of-the-art coverage, 25 brand-new chapters, and 45 new videos provide expert guidance on performing femtosecond-assisted penetrating keratoplasty, DSAEK, deep anterior lamellar keratoplasty, and many other cutting-edge techniques. Plus, you'll have easy access to the complete contents and illustrations online at expertconsult.Overcome any clinical challenge related to the cornea, external disease, anterior uveitis, and the expanding range of contemporary corneal surgery with the most complete, authoritative guidance source available.Get superb visual guidance with exceptionally clear illustrations, diagnostic images, and step-by-step surgical photographs.Access the complete contents and illustrations online at expertconsult.Make optimal use of Anterior Segment OCT to plan and choose treatment options and assess post-operative recovery.Master the latest surgical techniques—including femtosecond-assisted penetrating keratoplasty, DSAEK, and deep anterior lamellar keratoplasty—thanks to 25 brand-new chapters and 45 new videos on DVD (a total of 3 hours running time).Understand the full spectrum of corneal diseases with coverage of the new corneal dystrophy classification that incoporates current genetic, clinical, and pathologic information.

Cancer Symptom Science is the first interdisciplinary compilation of research on the mechanisms underlying the expression of cancer-related symptoms. It presents innovations in clinical, animal and in vitro research, research methods in brain imaging, and statistical-descriptive approaches to understanding the mechanistic basis of symptom expression. This volume also provides perspectives from patients, government and industry. By collecting and synthesizing the developing threads of new approaches to understanding cancer-related symptoms, the book promotes a pioneering framework for merging behavioral and biological disciplines to clarify mechanisms of symptom evolution, incorporating new technologies, testing novel agents for symptom control, and improving patient functioning and quality of life both during and after cancer treatment. With an expert editorial team led by Charles S. Cleeland, an internationally-recognized leader in cancer pain assessment and treatment, this is essential reading for surgical, clinical and medical oncologists, academic researchers, and pharmaceutical companies developing new agents to control symptom expression.

Galanin is a neuropeptide found both in the central and peripheral nervous system. The 29-amino acid peptide (named after its N-terminal glycine and C-terminal alanine) was identified in 1983 by its C-terminal amidation. This'reverse'approach, that is to discover a substance through a distinct chemical feature, and only subsequently to characterize its biological activity, was novel and has been successful in the identification of several other peptides. After the structure of galanin was determined in 1983, functional studies were performed with material purified from natural sources until the synthetic form of the peptide became available. Galanin can act as transmitter, modulator and trophic factor, and is involved in a number of physiological processes such as hormone secretion, cardiovascular mechanisms, feeding and cognition. This peptide may also be of significance for a number of pathological processes/disorders including pain, depression, Alzheimer's disease, epilepsy, addiction and cancer. This wide diversity of actions is mediated by three galanin receptor subtypes. The studies reviewed in this volume give a fairly complete overview of the spectrum of the biological actions and functions of galanin and its receptors and on possible therapeutic applications in a number of pathological conditions.

The neuroendocrine system plays a pivotal role in the control of growth, puberty, reproduction, and intermediate metabolism. The last decades have witnessed rapid progress in the understanding of the molecular and biochemical mechanisms involved in neuroendocrine function, paralleled by dramatic improvements in imaging techniques. In this volume an international group of basic and clinical investigators presents their latest research on neuroendocrine physiology, advances in the control of the onset of puberty and its disorders, and basic and clinical aspects of the GH/IGF-1 and hypothalamic-pituitary-adrenal axes. An entire section is dedicated to pituitary tumors, including genetics and neuroimaging, and another covers the neuroendocrine control of substrate metabolism, including hypothalamic obesity and anorexia. Pragmatic and topical, this book is a must read for pediatricians, endocrinologists and clinical researchers working in the field of pediatric neuroendocrinology.

Stockley's Drug Interactions, edited by Karen Baxter, remains the world's most comprehensive and authoritative reference book on drug interactions.: Contains detailed yet concise monographs; Covers interactions between therapeutic drugs, proprietary medicines, herbal medicines, foods, drinks, pesticides and drugs of abuse; Based on published sources and fully referenced; Global coverage - inclusion of drugs used worldwide; Provides comprehensive details of the clinical evidence for the interactions under discussion, an assessment of their clinical importance and gives clear guidance on how to.

The neuroendocrine system plays a pivotal role in the control of growth, puberty, reproduction, and intermediate metabolism. The last decades have witnessed rapid progress in the understanding of the molecular and biochemical mechanisms involved in neuroendocrine function, paralleled by dramatic improvements in imaging techniques. In this volume an international group of basic and clinical investigators presents their latest research on neuroendocrine physiology, advances in the control of the onset of puberty and its disorders, and basic and clinical aspects of the GH/IGF-1 and hypothalamic-pituitary-adrenal axes. An entire section is dedicated to pituitary tumors, including genetics and neuroimaging, and another covers the neuroendocrine control of substrate metabolism, including hypothalamic obesity and anorexia. Pragmatic and topical, this book is a must read for pediatricians, endocrinologists and clinical researchers working in the field of pediatric neuroendocrinology.

Nutrition and Metabolism: Underlying Mechanisms and Clinical Consequences brings together internationally recognized experts to comprehensively review our current understanding of how nutrition interacts with the genetic substrate as well as environmental-exogenous factors, including physical activity or the lack thereof, to result in insulin resistance and the metabolic syndrome. After presenting the scope of the problem, the first major part of the book is devoted to genetics and pathophysiology, the second part of the book presents the public health perspective of the most prevalent problems associated with nutrition and the metabolic syndrome, whereas the third major part of the book focuses on clinical assessment and management of the main disease states associated with inappropriate nutrition and the metabolic syndrome. Finally, general information useful for both clinicians and researchers alike is presented in the Appendix. Nutrition and Metabolism: Underlying Mechanisms and Clinical Consequences offers the reader an up-to-date and authoritative review of the major scientific and clinical aspects of the overlapping areas between nutrition and metabolism.

The first edition of The Endometrium was a landmark publishing event in reproductive biology and medicine. Many important developments have occurred in the field, and this new edition has been substantially updated and expanded to include new topics with an improved format. With the addition of several new authors and topics, the Second Edition of

Over the last decade it has been shown that orphan G protein-coupled receptors (GPCRs) can be used as targets to discover novel neuropeptides. A dozen neuropeptides have been identified through this approach. Each of these neuropeptides has opened new doors for our understanding of fundamental physiological or behavioral responses. For example the orexins, MCH and ghrelin carry fundamental roles in regulating food intake while neuropeptide S, neuromedin S, the prokineticins and the orexins are major players in modulating sleep and circadian rhythms. The chapters of this book review the latest research in the field, most of them are written by the original discoverers of the respective novel neuropeptide. Emphasis is set not only on their discovery but also on their functional significance. Since many of these neuropeptides are part of drug discovery programs, this book impacts academic as well as pharmaceutical research.

This new companion to Hochberg et al.'s Rheumatology masterwork presents current insights into the causes, detection, and therapy of this condition. It provides'one-stop'coverage of scientific and clinical developments, including new concepts in epidemiology and genetics and pathogenic mechanisms · new developments in diagnostic interventions and prevention · and the very latest concepts in treatment.Features the work of leading experts in osteoarthritis. Presents current diagnostic criteria and knowledge of pathogenic mechanisms.Discusses the very latest advances in treatment, including pharmacologic interventions.Provides new concepts in epidemiology and genetics of osteoarthritis, including modifiable and non-modifiable risk factors.

Dietary restriction uniquely and robustly increases maximum lifespan and greatly reduces age-related diseases in many species, including yeast, flies, nematodes, and mammals. To study mechanisms mediating the protective effects of dietary restriction, the National Institute of Aging convened a program involving several leading gerontological laboratories. Results from many of these, as well as from other leading research institutions in the field, are presented in this book. The first three papers address general molecular mechanisms, derived in part from recent DNA microarray studies, that may mediate protective effects of dietary restriction. The subsequent articles examine specific model systems, including flies, nematodes and non-human primates, that have provided exciting new information about these mechanisms. Finally, mechanisms of dietary restriction mediating protective effects against cancer and neurological diseases are discussed. In addition to gerontologists and geriatricians, many other medical and nonmedical professionals in the field will find a great wealth of information on possible interventions that may ameliorate age-related diseases.

While nutrition is central to the management of diabetes, there is no onediabetic diet. Nutritional prescriptions depend on the type of diabetes, food preferences, lifestyle, treatment regimen, comorbidities, state of health, and the route of caloric administration. Nutritional Strategies for the Diabetic/Prediabetic Patient is a comprehensive r

Cardiovascular diseases continue to be the leading cause of death in the - jority of industrialized countries. The most frequent underlying pathology, namely atherosclerosis, and its clinical sequelae, namely coronary heart d- ease, cerebrovascular disease and peripheral artery disease, remain common although for a long time we have been made aware of avoidable or mo-?able etiological factors such as smoking, fat-rich diet or lack of exercise, and although these adverse lifestyle factors have been extensively addressed by population-wide primary prevention programs. Cardiovascular morbidity and mortality also remain high despite successful anti-hypertensive and lipid lowering drug therapies which help to reduce cardiovascular morbidity and mortality by about 30% in both secondary and tertiary prevention settings. This can partly be explained by the increasing life expectancy and growing p- portionofelderly people,especiallyinEuropeandNorthAmerica. Inaddition, the World Health Organization makes the alarming prediction that probably in response to the spreading of western dietary behavior and lack of exercise resulting in an increasing prevalence of diabetes, dyslipidemia and hypert- sion, cardiovascular diseases rather than infectious diseases will become the most frequent cause of death worldwide. This volume of the Handbook of Experimental Pharmacology entitled “Atherosclerosis” is divided into four parts and intends to give an overview on the pathogenesis of atherosclerosis, established treatment and prevention regimen, and of perspectives for the development of new treatment modalities.

According to estimates of the World Health Organization, 80% of the world population is primarily reliant on such traditional methods of healing as medicinal plants. This timely text assesses 25 common plants from several countries, providing practical and evidence-based recommendations for their application. This book essential for all practitioners working in developing countries who must understand the characteristics of medicinal plants.

- El síndrome metabólico es uno de los retos más intrigantes y fascinantes de la medicina contemporánea. Se trata de una patología en la que confluyen problemas de distintas áreas de la medicina: diferentes grados de hipertensión, acumulación de grasa, insulinoresistencia, estados protrombótico y proinflamatorio, todos juntos en la misma persona. Esta concurrencia de factores hace que la persona tenga un riesgo mucho mayor de sufrir enfermedad cardiovascular o diabetes mellitus tipo 2, que lo que la suma de los factores individuales supondría. - Se trata de una'enfermedad'nueva, que ha llegado a ser un problema de salud pública muy importante en las sociedades desarrolladas y cuya rápida extensión se debe fundamentalmente a la adopción del estilo de vida occidental: fundamentalmente, muy poca actividad física e ingesta excesiva de alimentos. - Esta obra trata el concepto del Síndrome metabólico en su más amplio sentido y da respuesta a la multitud de incógnitas que todavía presenta esta patología. Con un enfoque multidisciplinar y un equipo de colaboradores internacionales (España, Italia, Japón, Alemania, Estados Unidos, Reino Unido, Finlandia, Australia, etc.) de primer nivel en las distintas áreas, escrita íntegramente en inglés, revisa todos los aspectos relacionados con el Síndrome metabólico, desde el punto de vista de la fisiopatología molecular y la epidemiología genética: obesidad, insulinoresistencia, dislipidemias, hipertensión, enfermedad cardiovascular y otros nuevos como inflamación molecular, estado protrombótico, disfunción endotelial... - Todos los capítulos presentan un abstract, en inglés y castellano, al inicio de cada capítulo con los puntos fundamentales que se van a desarrollar en ese capítulo. - Esta obra trata el concepto del síndrome metabólico en su más amplio sentido y da respuesta a la multitud de incógnitas que todavía presenta esta patología. - Se trata de una'enfermedad'nueva, que ha llegado a ser un problema de salud pública muy importante en las sociedades desarrolladas y cuya rápida extensión se debe fundamentalmente a la adopción del estilo de vida occidental. - Todos los capítulos presentan un abstract, en inglés y castellano, al inicio de cada capítulo, con los puntos fundamentales que se van a desarrollar en ese capítulo.

Offering perspectives on the history, prevalence and genetics of obesity, this book examines the origins and etiology of obesity. It considers the relationship between behavioural neuroscience and obesity.

Obesity has become the most common chronic disease of the present day, with significant increases in prevalence in populations across the world and all age groups. This has resulted in a dramatic increase in obesity-related metabolic and cardiovascular complications, making it an important public health issue. Type 2 diabetes associated with obesity or'diabesity'is today the most common form of type 2 diabetes. It is also associated with a number of other cardiovascular risk factors, which constitute the metabolic syndrome. Effective management of'diabesity'is crucial to the reduction of morbidity and premature mortality due to cardiovascular disease. This book comprises chapters written by leading international experts on various aspects of obesity-related diabetes. As a practical reference guide, it is suitable for all professionals with an interest in this field. Emerging problems such as childhood'diabesity'and the impact of obesity on polycystic ovary syndrome will be of interest not only to paediatricians and endocrinologists, but also to general practitioners and other healthcare professionals. The contemporary approach to the clinical assessment of obesity and its management in both primary and secondary care settings is also described.

This text presents the latest advances in supercritical fluid technology, biocatalysis, bioprocess engineering, and crop breeding. It offers an in-depth review of the most recent principles and approaches utilized in the development and design of lipids for cosmetic, industrial and pharmaceutical, and food products. Discussing a variety of lipid-ac

What does it mean to talk about a `national'cinema? To what extent can British cinema, dominated for so many years by Hollywood, be considered a national cinema? Waving the Flag investigates these questions from a historical point of view, and challenges the received wisdoms of British cinema history in many ways. Andrew Higson investigates theories of national cinema, and surveys the development of the British film industry and film culture. Three case studies combine histories of production and reception with textual analysis of key films from the 1920s, 1930s, and 1940s such as Sing As We Go, Comin Thro the Rye, andThis Happy Breed. Drawing some revealing conclusions about the extent to which the many rich traditions of British film-making share the same distinctive stylistic and ideological characteristics, what emerges is a sometimes surprising picture of a specifically national cinema. Combining detailed analyses of film texts with studies of industrial and cultural contexts, including critical reception, Waving the Flag is an impressive and wide-ranging survey of the concept of national cinema as it has developed in Britain. `by far the best book about British film yet published', Choice `a thoughtful, stimulating, and well-researched book.', Sunday Telegraph `this painstaking piece of scholarship, which manages to home in on the most minute narrative and stylistic details of the films under scrutiny and to excoriate notions of what'Britishness'is all about.', `a valuable addition to British film writing...which adds considerably to our understanding of British cinema history', Screen `the book is packed with detailed analysis, dense arguments, and an impressive breadth of cultural reference', Media, Culture, and Society `an exciting new book...valuable to all those concerned with how the cultural analysis of film relates to the economic context.'Film Quarterly