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Although the vast majority of diabetes cases (type 1 and type 2) are polygenic diseases, research, funded by the American Diabetes Association, has found that some forms of diabetes, distinct from type 1 or type 2 diabetes, are caused by single gene mutations. It has been estimated that these monogenic forms of diabetes account for up to five percent of all diabetes cases. In addition to monogenic diabetes, there are other atypical causes of diabetes, including: genetic defects in insulin action; diseases of the exocrine pancreas; and endocrinopathies. Given recent advances in our understanding of sub-types of diabetes, the time has come for a book on how to correctly diagnose and treat patients with atypical forms of this disorder. The book will be divided into three parts, each exploring distinct categories of atypical diabetes. Part I: Monogenic Diabetes: Genetic Defects of β-cell development and function; Part II: Insulin resistance, genetic defects in insulin action, and diseases of exocrine pancreas; Part III: Endocrinopathies, Immune-mediated diabetes, Diabetes of Unknown cause, and Other genetic syndromes sometimes associated with diabetes.

Pancreatic B Cell Biology in Health and Disease, Volume 360 presents the latest release in this ongoing series on the novel and widely studied physiology of pancreatic cells in homeostasis and under pathogenic conditions. This new volume includes new chapters on a variety of topics, including Pancreatic Beta Cell Dysfunction in Type 1 Diabetes: The Role of Ifn, Sexual Hormones and Diabetes: The Impact in Pancreatic Beta Cell, Pancreatic Beta Cell Dysfunction in Monogenic Diabetes, The Role of MiRNAs In Beta Cell Function, Pancreatic Beta Cell: How Environmental Endocrine Disruptors Alter Its Function, Enteroviral Infections and Pancreatic Beta Cell Dysfunction, and more. Final sections cover Long Non-Coding Rna-Regulated Pathways in Pancreatic Beta Cell: Their Role in Diabetes and Pancreatic Beta Cell Biology in Health and Disease. - Provides updated and extensive review articles that focus on different aspects of pancreatic cell biology - Offers a wide range of perspectives for basic and translational research - Includes original figures that help readers understand the complex pathways involved in cell function in homeostasis and under pathogenic conditions

This volume, written by renowned experts, provides complete coverage of the main genetic conditions associated with diabetes. Divided into five sections, it offers insights into genetic defects involving the pancreatic beta cell, extreme insulin resistance, ciliopathies, obesity and glucose metabolism, chromosomal defects, and other genetic conditions associated with increased susceptibility to diabetes. Other topics include the various subtypes of monogenic diabetes, such as the neonatal form and the Wolfram syndrome, as well as chromosomal defects leading to complex conditions affiliated with diabetes, like Trisomy 21 or Prader-Willi syndrome. There are also chapters dedicated to the poorly explored relationships between metabolism and neurodegenerative disorders like Friedreich's ataxia and muscular dystrophy. This book is a reference for every pediatric and adult endocrinologist and diabetologist, even experienced ones, with an interest in the intricacies and protean aspects of disorders of glucose metabolism secondary to genetic diseases.

The book Case Based Reviews in Pediatric Endocrinology is organized into seven sections with a total of twenty-four chapters. The first section deals with disorders of growth and puberty that form the core of the practice of pediatric endocrinology. Included in this section are chapters that deal with disorders of sexual development and hyperandrogenism in girls. The second section contains chapters that discuss common problems related to the thyroid and adrenal glands. The third section addresses issues related to carbohydrate metabolism including hypoglycemia, type 1 diabetes mellitus, and monogenic diabetes. The related topics of obesity, metabolic syndrome, and type 2 diabetes mellitus are grouped together in the fourth section. Section five deals with disorders of water and electrolyte imbalance. Included in this section are disorders of calcium metabolism and the topic of rickets that is still a common condition in many parts of the developing world. The penultimate section contains a discussion into the pleiotropic endocrine manifestations of systemic diseases and therapies. This section also outlines the approach to child with inherited metabolic disease since these conditions can present to a pediatric endocrinologist with symptoms such as hypoglycemia or growth failure suggestive of a primary endocrine problem. The final section includes chapters on investigative techniques, both radiological and dynamic laboratory protocols, relevant to pediatric endocrinology. This book will prove to be a valuable resource in the practice of pediatric endocrinology and lead to early diagnosis and treatment of children affected by these disorders.

For decades, Emery and Rimoin's Principles and Practice of Medical Genetics and Genomics has served as the ultimate resource for clinicians integrating genetics and genomics into medical practice. With detailed coverage in contributions from more than 250 of the world's most trusted authorities in medical genetics and a series of 11 volumes available for individual sale, the seventh edition of this classic reference includes the latest information on seminal topics such as prenatal diagnosis, genome sequencing, public health genetics, and genetic counseling. Volumes 3–11 cover diagnosis, management, and treatment of both rare and common disorders in all organ systems. Students, medical providers, and researchers all benefit from the latest information about the role of the genome in health and disease. This comprehensive yet practical resource emphasizes theory and research fundamentals across the full spectrum of applications to medicine. In this volume, leading physicians and researchers thoroughly examine medical genetics and genomics as applied to endocrine, skin, connective tissue and skeletal disorders, with emphasis on understanding the genetic mechanisms underlying these conditions, diagnostic approaches, and treatment methods that make use of current genomic technologies and translational studies. With regular advances in genomic technologies propelling precision medicine into the clinic, Emery and Rimoin's Principles and Practice of Medical Genetics and Genomics, seventh edition, bridges the gap between high-level molecular genetics and genomics and practical application and serves as an invaluable clinical tool for the health professionals and researchers. - Thoroughly introduces genetic researchers, students, and healthcare professionals to the genetic and genomic bases of endocrinologic, dermatologic, connective tissue, and skeletal disorders - Includes color images supporting identification, concept illustration, and method processing - Features contributions by leading international researchers and specialist medical practitioners

This book contains the essential information required by physicians and bench scientists to understand the definition of a given autoimmune disease and its diagnostic criteria and treatment. Autoimmune diseases are a family of more than one hundred chronic, and often disabling, illnesses that develop when underlying defects in the immune system lead the body to attack its own organs, tissues, and cells. In Autoimmune Disease Diagnosis: Systemic and Organ-specific Diseases, the editors have gathered a critical review by renowned experts of more than 120 autoimmune diseases. A contemporary overview of these conditions with special emphasis on diagnosis is presented. This edition of Autoimmune Disease Diagnosis is divided into two parts, the first covering systemic autoimmune diseases, and the second covering organ-specific autoimmune diseases. They cover all the newly approved classification criteria, such as those for systemic lupus erythematosus, antiphospholipid syndrome, several systemic vasculitis, etc. This edition also reviews newly described systemic autoimmune conditions: immune-mediated necrotizing myopathy, VEXAS, immunoglobulin G4-associated autoimmune disease, autoimmune/autoinflammatory syndrome induced by adjuvants (ASIA), and autoimmune manifestations induced by immune-therapies. Several organ-specific diseases have been added, including autoimmune alopecia and other immune-mediated dermatosis, autoimmune encephalitis, and autoimmune dysautonomia, among others. This is an essential guide to the diagnosis of autoimmune diseases for internists, rheumatologists, clinical immunologists, primary care physicians, and bench scientists.

'This book on health education and promotion should cover a wide range of topics, including the principles and theories behind health education, the role of behavior change in health promotion, and strategies for promoting healthy behaviors. It provides readers with a solid foundation in the history, philosophy, theory, and ethics of health education. Its primary beneficiaries are students who are preparing for careers as health educators or health promoters. This text teaches the educator to be aware of the many factors that influence health: heredity, environment, health care services, and our own behavior This book can serve as a valuable resource for students pursuing degrees in public health, health education, nursing, medicine, and Colleges, and universities may use the book as part of their curriculum for health-related courses or as a resource in their libraries.'

Cardiometabolic diseases are a group of metabolic dysfunctions mainly characterized by insulin resistance, impaired glucose tolerance, dyslipidemia, hypertension, and central adiposity that are major contributors to increased risk of acute vascular events such as myocardial infarction, heart failure and stroke. Cardiometabolic Diseases: Molecular Basis, Early Detection of Risks, and Management provides detailed information on all aspects of metabolic dysfunctions and associated risks for cardiometabolic diseases, including a thoughtful discussion of cellular and molecular mechanisms involved in the progression of metabolic risks, the approaches for the early detection and robust management of metabolic risks. Written by a team of expert contributors, this book is useful reading for researchers and clinicians interested on recent advances in etiology of cardiometabolic diseases, the latest noninvasive approaches for diagnosis, risk assessment tools, therapeutic strategies, and also aspects of prevention of cardiometabolic diseases. - Covers all aspects of cardiometabolic diseases, from cellular and molecular mechanisms involved in the development of metabolic risks to clinical practice - Provides established guidelines that facilitate effective management of the independent risk factors that promote vascular diseases - Discusses the use of diagnostic tools to empower patients to self-monitor the progress or regress of modifiable risks

The second edition of this text has proved to be a very successful pediatric study guide, helping many pediatricians around the world to study pediatrics in a very easy, simplified way. Even the most complex subjects are condensed into very straight forward and easy to remember information blocks. This book not only prepares students to pass their exams but also prepares pediatricians for general pediatric encounters, emphasizing all new updates from the American Academy of Pediatrics and American Board of Pediatrics. It has proved very popular among new pediatricians and new pediatric residents worldwide. In the last 3 years, the AAP and ABP have released a lot of updates, such as, management of fever in well-appearing infants, COVID-19, asthma management, and new vaccine guidelines from the CDC. The pediatric board exam always includes new diseases, which are included in each chapter, as well as new questions and answers that must be added to the last-minute review chapter, as well as other questions to be edited to follow the new recommendations and guidelines in pediatrics. New pictures and better quality illustrations are also included. Pediatric residents and fellows preparing for the board examination, pediatricians, and pediatric subspecialists preparing for certification maintenance will find Pediatric Board Study Guide: A Last-Minute Review, 3rd edition, easy to use and comprehensive, making it the ideal resource and study tool.

Digital Healthcare, Digital Transformation and Citizen Empowerment in Asia-Pacific and Europe for a Healthier Society explores the potential of advanced IT in healthcare. This book shares insights on leveraging IT tools to address global disruptions like the pandemic, offering case studies from various regions, innovative topics in digital healthcare, lessons from the COVID-19 pandemic, and recommendations for policymakers worldwide. This title is a valuable resource for researchers, clinicians, CEOs, and policymakers seeking to learn from both failures and successes and harness the potential of advanced information technologies to enhance healthcare systems and services. - Shows the urgent need to understand the potential of advanced IT for the healthcare sector - Gives insight into the successes and failures during pandemics - Exploits the potential of AI, big data, and knowledge management to provide better healthcare services and more digital inclusion of citizen - Includes study cases in the field of IT and digital health during the pandemic and analyses lessons learned

Written by a cadre of experts, this new edition provides a comprehensive, authoritative, and international view of gestational diabetes mellitus and will be invaluable to maternal-fetal medicine specialists, diabetologists, neonatologists, and a growing number of gynecologists and general physicians concerned with the management of noncommunicable diseases in pregnancy. Offers a comprehensive and authoritative guide to all aspects of the subject internationally Presents an invaluable resource for all working in diabetes, maternal-fetal medicine, and obstetrics Shows the latest developments in research in genomics and in practice with the digital clinic

Implementation of Personalized Precision Medicine: Expanding the Clinical Vision towards Prevention, Early Detection, and Precision Treatment of Disease to Drive Extended Healthspan establishes the landscape of precision medicine as it stands in relation to implementation of individualized approaches based on the patient's unique genomic and biochemical make-up to facilitate prevention, early detection and personalized interventions. This reference details how these lofty goals are now achievable with the science of today (and tomorrow) and provides the context and blueprint allowing researchers and clinicians to avoid, and more effectively treat, complex chronic disease.At the heart of precision medicine lies one concept that has been missing from modern medicine–the unique genetic and biochemical make-up of each individual patient. Uniquely organized, this reference reflects this concept and provides insights into patient constitution, genetic inherited risk, current epigenetic modifications, and current biochemical state, making this reference valuable to researchers and science-minded providers who modified, reverse or prevent disease progression. - Explores the expanding paradigm of Precision Medicine application highlighting full personalization in precision medicine. - Explores the gap between precision medicine implementation and medical policy, showing the integration and implementation of technologies in primary care for chronic disease. - Provides fresh viewpoints and perspectives for researchers and science-minded providers on the forefront of implementation, to be informed of the best available tools and approaches for each individual patient.

CRISPR-Cas-Based Genome Editing for Treating Human Diseases, Part B represents CRISPR-Cas systems for genome editing. Currently, CRISPR-Cas systems have been proven to be a key technology for targeted genome editing, which is acting as a simple, rapid, and cost-effective solution. Chapters in this release include Current approaches in CRISPR –Cas systems for metabolic disorders, Recent progress in CRISPR –Cas systems for CRISPR for retinal diseases, Recent progress in CRISPR –Cas systems for cataract and blindness, Advances in CRISPR –Cas systems for muscular dystrophy, Recent development in CRISPR –Cas systems for cardiac disease, Current approaches in CRISPR –Cas systems for diabetes, and much more.Additional sections cover Advances in CRISPR –Cas systems for liver disease, Advances in CRISPR –Cas systems for lung disease, Advances in CRISPR –Cas systems for kidney diseases, Current progress in CRISPR –Cas systems for rare disease, Advances in CRISPR –Cas systems for heredity disease, Recent progress in CRISPR –Cas systems for neurological disorders, and CRISPR challenges in clinical developments. - Provides CRISPR-Cas systems for metabolic disorders, retinal disease cataracts, and blindness - Offer updates on muscular dystrophy, cardiac disease, diabetes, and liver disease - Includes content on lung disease, kidney diseases, rare diseases, heredity diseases, neurological disorders, and CRISPR challenges in clinical developments

Deep Learning in Diabetes Mellitus Detection and Diagnosis focuses on deep learning-based approaches in the field of diabetes mellitus detection and diagnosis, including preprocessing techniques that are an essential part of this subject. This is the first book of its kind to cover deep learning-based approaches in the specific field of diabetes mellitus. This book includes a detailed introductory overview as well as chapters on current applications, preprocessing of data using deep learning, deep learning techniques, complexity, challenges, and future directions. It will be of great interest to researchers and professionals working on diabetes mellitus as well as general medical applications of machine learning.Features: Highlights how the use of deep neural networks-based applications can address new questions and protocols, as well as improve upon existing challenges in diabetes mellitus detection and diagnosis Assists scholars and students who might like to learn about this area as well as others who may have begun without a formal presentation, with no complex mathematical equations Involves exceptional subject coverage and includes the principles needed to understand deep learning

Pathophysiology: A Practical Approach, Fifth Edition provides an innovative, practice-ready, approach to foundational pathophysiology for pre-licensure nursing students. The text is organized by body system and is presented in an easy-to-read format with vibrant graphics and practice tools. Dr. Story takes a student-focused approach to the challenging subject. She organized the content into topical chapters that walk students through their base knowledge of A&P, what can go wrong with the human body, how to identify it, and what to do about it. This st-udent-friendly approach empowers readers to take a more active role in learning pathophysiology. Students and faculty praise Pathophysiology: A Practical Approach for its innovative presentation, helpful Next Generation NCLEX-style questions, approachable reading style, dynamic images, and coverage of current research.

•Competency-based curricular changes recommended by NMC incorporated as core/must-know, and non-core/desirable-to-know and their corresponding new assessment methods included. •Updated text in academic and diagnostic pathology includes current definitions, additional causes, contemporary mechanisms, up-to-date international classifications of diseases (including WHO classifications of neoplasms, 5th edition) and modern approach to diagnosis and prognosis, in a simple, lucid, easily understandable and reproducible, user-friendly format. •Newer content includes a new chapter on ‘Blood Banking and Transfusion'and another on ‘Clinical Pathology'incorporated in Appendix I along with Basic Diagnostic Cytology. Pathology of COVID-19 and its impact on different organ-systems incorporated in different chapters. •Labelled gross and photomicrographs of high quality and better resolution added and amended, many of these were generously contributed by Prof Ivan Damjanov in previous edition, several schematic illustrations updated and amended. •New tables added at several places for enhanced learning. •Key points as gist at the end of every topic in bulleted points for a rapid revision of the subject in an ultra-short time. •Chapter orientation paragraph given at the beginning of every chapter to peek through the entire chapter and meant to aid the user in systematic and organised learning. •Revised companion book prepared exclusively on the pattern of competencies/outcomes as recommended by the NMC is given for free to the user of the textbook for a quick review of the subject. •Complimentary online learning resource includes high-yield questions (long-answer type, short-answer type, MCQs, clinical scenario-based and image-based) and clinical cases along with key and explanatory notes. •Cheers! No overburdening!! With all these additions and insertions, girth of the book remains unaltered, care having been taken not to overburden the already stressed students.

MEDICINE UPDATE • Medicine Update is being published as a comprehensive two-volume book divided into 20 sections comprising 281 chapters. • It includes chapters from leading experts from the field of medicine from India and overseas. • The book is a compilation of the current understanding of various aspects in medicine and up-to-date information from the available research data. • The book may prove to be a valuable resource for physicians and postgraduates in their day-to-day practice. PROGRESS IN MEDICINE •This book includes the scientific proceedings of the CME of APICON 2024. •It is organized into parts for different systems covering a wide range of pertinent clinical subjects. •It is helpful in everyday decision-making as well as postgraduate examination. •Recent updates on evidence-based guidelines for management and clinical medicine are provided. •This book includes chapters contributed by specialists in genetics, modern technology, and fundamental sciences. •Some chapters focus on soft skills, which are becoming more crucial in today's world •Topics that are frequently overlooked, like travel medicine, medical education, medicolegal concerns, and gerontology, are also included.

Pediatric Endocrinology covers all of the main aspects of translational endocrinology and clinical practice, making it an ideal resource for both paediatricians and endocrinologists. The book emphasizes the newer translational aspects of the topics covered, as well as molecular advances in diagnosis and therapy, although clinical relevance, with a particular focus on evidence-based clinical management, remains paramount. Further, transitions from childhood to adolescence and adulthood are discussed wherever appropriate. Written by a combination of respected and emerging experts in the field, this book is intended to serve as a major reference work for pediatric endocrinologists at all stages of their careers, as well as general pediatricians with an interest in endocrinology and diabetes, and endocrinologists in adult practice who may also treat children and adolescents. The book is part of the SpringerReference program, which provides access to ‘living editions'thatare constantly updated using a dynamic peer-review publishing process.

Engage on a captivating journey through the chronicles of medical history with Historical Landmarks in Endocrinology and Diabetes. Covering the exciting landmarks that have shaped the field of endocrinology as we know it, this book traces the evolution of endocrinology through its most pivotal landmarks and provides a concise and captivating account of the pivotal moments in the history of endocrinology branches.In addition to authoring, Dr. Bayar Qasim has contributed to the licensing, designing and editing of artwork and images featured in this book. With captivating tales and artistic depictions, this book immerses readers in the vast tapestry of endocrinological history. Whether you're a healthcare professional, researcher, or simply interested by the world of hormones and its history, this publication is for you. With a blend of storytelling and artistic flair, this book promises to inspire and leave readers eager to uncover more about the world of endocrinology and diabetes.