Search

The third edition of this acclaimed work provides clinicians and investigators with a wealth of state-of-the-art information that will lead to fresh approaches in thinking about liver physiology and liver diseases. Developed by a panel of renowned international authors, this edition outlines a range of important advances in our understanding of the liver's role as an immune organ and the functions of innate and adaptive immunity in the pathogenesis of all liver diseases. Indeed, the liver is a vitally important immune organ producing liver-derived products that can trigger the innate and adaptive immune system to initiate, mediate, regulate, and resolve systemic inflammation. The book begins with an analysis of the core concepts of immunology, including the definition of autoimmunity and its unique application to the liver, a tolerogenic organ. Subsequent chapters then explore the biological elements of liver diseases caused by epigenetics, genetics, and innate and adaptive immunity. Specific clinical presentations and aspects of liver diseases are also examined, such as Hepatitis C, non-alcoholic fatty liver disease and parasitic infections. Closing chapters then discuss liver diseases among specific populations, including pediatrics, those with comorbidities and preexisting conditions, pregnant women, and finally patients with transplanted organs. A timely and invaluable update to the clinical literature, Liver Immunology: Principles and Practice, Third Edition, is once again a comprehensive work that will not only enhance the understanding of liver diseases but also provide the kind of novel insights that greatly accelerates the evidence-based care of children and adults afflicted with these diseases. This volume is again a must-read for clinicians at all levels, for investigators and for students.

Hepatologie konkret - komplett - kompaktErfahrene Kliniker führen übersichtlich, zusammenfassend und gewichtet durch das Gebiet der Leber- und Gallenwegserkrankungen.Komplexe Inhalte werden anschaulich, klar und gut verständlich dargestellt. Differenzierte Diagnostik und Therapie: Was - Wann - WarumNeueste diagnostische und therapeutische KonzepteRasche, präzise InformationKonzentration auf krankheitsbezogene klinische Informationen Therapie individuell abgestimmt auf Ihre PatientenStandardsTherapie für multimorbide PatientenLösungen für typische und atypische Therapieprobleme Zur sofortigen sicheren AnwendungEntsprechend der neuesten Studien und Leitlinien aller wichtigen deutschen, europäischen und amerikanischen Fachgesellschaften

Liver Immunology: Principles and Practice, Second Edition begins with important information about the epidemiology and mortality of liver disease worldwide. This information is followed by chapters related to basic immunology, application of liver immunology for diagnosis, and several excellent chapters that provide a solid foundation for understanding immune-mediated liver disease, including those associated with the biliary tree. A chapter on non-hepatic manifestations of immune mediated liver disease helps provide context for how these diseases affect the patient overall. In addition, chapters discuss various discrete immunologically-mediated infectious liver disorders including those related to bacteria, parasites, and all of the classic viruses. Chapters on the traditional autoimmune liver diseases -- primary biliary cirrhosis, autoimmune hepatitis, primary sclerosing cholangitis as well as overlap syndrome – are also included. The breadth of this comprehensive second edition is highlighted by chapters on alcoholic liver disease, non-alcoholic fatty liver disease, and drug-induced liver disease, among others. This invaluable new edition ends with a forward-looking view of future directions and how the field might meet the challenge of refractory patients. Developed by a renowned group of authors, Liver Immunology: Principles and Practice, Second Edition will again serve as a comprehensive textbook by providing an excellent overview for this rapidly evolving field. It greatly adds to the understanding of the pathogenesis of these diseases, while also providing novel insights that can be harnessed into helping improve the care of patients afflicted with various immune-mediated diseases. This volume will again be a must-read for clinicians at all levels, investigators andstudents.

Ausgehend von aktuellsten Daten werden die molekularbiologischen Grundlagen von gastrointestinalen Malignomen, des Leberzellkarzinoms, molekulare Mechanismen von Stoffwechseldefekten, die Interaktion von Hormonen und Zytokinen in der Regulation von gastrointestinalen Funktionen, die Bedeutung von Sauerstoffradikalen und Stickstoffmonoxyd in der Gastroenterologie sowie der Darm als Immunorgan und erste Ansätze zur Gentherapie in der Gastroenterologie dargestellt. Das Buch erröffnet einen kausalen Zugang zur Gastroenterologie, neue - molekularbiologische - diagnostische Ansätze werden ebenso dargestellt wie erste gentherapeutische Möglichkeiten.

Zakim and Boyer's Hepatology—the defining work in hepatology—presents comprehensive coverage of both basic science and clinically relevant developments so you can provide the best possible patient care. Drs. Thomas Boyer, Michael Manns, and Arun Sanyal have reorganized and updated the contents of this trusted global reference to reflect today's more clinical approach to hepatology. They bring you up to date on hot topics including HIV Co-Infection Drug Toxicity, Hepatocellular Carcinoma (HCC), and much more. This new streamlined edition is now a single volume making it easier to find the treatment information you need. Effectively treat all liver diseases currently seen in clinical practice with authoritative guidance from leading international authorities. Reinforce your foundation in basic science with the concise Pathophysiology of Therapeutic Targets section. See clear presentations of liver disease through hundreds of detailed, color illustrations. Explore topics further with up-to-date references that direct you to the significant literature. Stay current on new developments in the field through five new chapters on Pathogenesis Liver Injury in HBV, HCV; HCC; Imaging and Non-Invasive DX Liver Disease CT, US, Fibroscan, MRI; HIV Co-Infection Drug Toxicity; and HBC, HCV in Non-Liver Transplant Patients, plus comprehensive updates throughout. Apply best practices with reorganized and updated content that reflects today's need for a more clinical approach to hepatology.

El presente manual trata las manifestaciones típicas y atípicas de la hepatitis autoinmune. Teniendo en cuenta los últimos descubrimientos científicos, ofrece al interesado una visión completa sobre numerosos temas relevantes para la práctica clínica con pacientes que padecen hepatitis autoinmune. Junto al diagnóstico razonado, se insiste especialmente en la descripción detallada del desarrollo clínico y del estado actual de las posibilidades terapéuticas y del trasplante hepático.

This textbook deals with the typical and atypical manifestations of autoimmune hepatitis. It offers the individual with a clinical interest in this condition a comprehensive review of many topics of relevance to clinical practice in the management of patients with autoimmune hepatitis taking into account the most recent scientific findings. In addition to efficient diagnostic investigation, the clinical course and current state of the art for therapy including liver transplantation are, in particular, described in detail.

Das vorliegende Lehrbuch befasst sich mit den typischen sowie atypischen Manifestationen der Autoimmunhepatitis. Es bietet dabei dem klinisch Interessierten einen umfassenden Überblick über eine Vielzahl von praxisrelevanten Themen bei der Betreuung von AIH-Patienten unter Berücksichtigung neuester wissenschaftlicher Erkenntnisse. Neben einer rationellen Diagnostik wird insbesondere der klinische Verlauf und der aktuelle Stand der Therapie bis hin zur Lebertransplantation ausführlich beschrieben.

Weltweit sind etwa 170 Millionen Menschen von einer Hepatitis-C-Virusinfektion betroffen. Trotz zahlreicher Fortschritte der modernen Medizin sind noch viele Fragen offen. Dieses Buch gibt in der vorliegenden 3. Auflage einen Überblick über den aktuellen Stand der Grundlagenwissenschaften und klinischen Forschung im Bereich Hepatitis C. Es werden neben Molekularbiologie des Hepatitis-C-Virus und Immunpathogenese die Bereiche Epidemiologie, Diagnostik, Therapie von Standard- und Problempatienten, hepatozelluläres Karzinom, Organtransplantation und neue therapeutische Entwicklungen behandelt. Dieses Lehrbuch berücksichtigt neben den Entwicklungen zur Therapieindividualisierung außerdem die neuen Empfehlungen der im Herbst 2009 erscheinenden aktualisierten Leitlinie zur Behandlung der Hepatitis C und ist ein praktischer Ratgeber für Klinikärzte, niedergelassene Kollegen und Studenten.

Immunology is a broad branch of biomedical science that covers the study of all aspects of the immune system in all organisms. It deals with, among other things, the physiological functioning of the immune system in states of both health and disease; malfunctions of the immune system in immunological disorders (autoimmune diseases, hypersensitivities, immune deficiency, allograft rejection); the physical, chemical and physiological characteristics of the components of the immune system in vitro, in situ, and in vivo. Immunology has various applications in several disciplines of science, and as such is further divided. Liver Immunology: Principles and Practice covers bacterial, parasitic and viral infections of the liver, autoimmune liver disease, alcoholic and nonalcoholic fatty liver diseases, and transplantation in an easy-to-read and thorough format. Authors also address the key issues that have arisen in this field in recent years, including physiological roles of hepatocytes, sinusoidal lining cells, activated macrophages (Kupffer cells), cholangiocytes and stellate cells, and their modulation of T cells, natural killer (NK) cells and NKT cells. This volume will become a must-read for clinicians, investigators and students, novice and expert alike.