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Introducing the biology of neoplastic disorders, this accessible book looks at how cancer damages the body, and how the treatments work. Updated with the most recent research evidence, this unique text explains the basic biology of neoplastic disease; discusses the biology of the wide range of common cancers, now including neurological disorders; identifies and explains the biological causes of cancer, with a focus on genetics, hormones, and environmental factors; explains drug action in chemotherapy and analgesia; discusses the role of nutrition in neoplastic disorders and their treatment. Presenting the essential knowledge for working with cancer patients and their families, this textbook is an important read for those working in cancer care or undertaking study in this area.

This book explores how defects in extracellular matrix (ECM) proteins, their post-translational modifications, and intracellular trafficking impact cartilage and bone integrity. It underscores the ECM's role in providing structural support, establishing morphogenetic gradients, and interacting with cell surface receptors in musculoskeletal tissues. The book delves into the structure and biology of the ECM in the skeleton, discussing skeletal disorders caused by mutations in genes associated with ECM proteins, synthesis, turnover, and signal transduction. Authored by experts who have made significant discoveries in the molecular mechanisms of skeletal disorders and are developing therapeutic strategies, this book is an invaluable research for both scientists and clinicians seeking a comprehensive understanding of this growing and exciting field. The series Biology of Extracellular Matrix is published in collaboration with the American Society for Matrix Biology and the International Society for Matrix Biology.

This book delves into the nuanced interplay of colour in human perception and its applications across diverse fields, highlighting the transformative impact on art, design, digital media, and technology. The book introduces an innovative approach by integrating scientific research with practical applications, making it a pivotal resource for designers, psychologists, and technologists. Its scope ranges from foundational aspects of colour vision to futuristic applications in virtual reality and artificial intelligence, offering fresh insights and forecasting emerging trends. This comprehensive exploration is essential for anyone interested in the strategic use of colour to enhance user experience and cultural expressions.

This book presents advanced research on smart health technologies, focusing on the innovative transformations in diagnosis and treatment planning using medical imaging and data analysed by data science techniques. It shows how smart health technologies leverage artificial intelligence (AI) and big data analytics to provide more accurate and efficient diagnosis and treatment planning. In search for innovative and novel methods and techniques for health technologies and medical data processing, the book • Discusses applications of Artificial Intelligence, Data Science, Machine Learning, Deep Learning, the Internet of Things, Big Data, Cloud Computing;• Includes use of electronic patient records in healthcare, analysis of big data in medical diagnosis, reliability, and challenges of EPR and EHR in smart healthcare;• Explores evolving techniques for smart healthcare, its application in medical imaging and prediction in the fields of treatment planning;• Provides recent studies in AI-driven healthcare technologies and medical imaging to outline insight into smart healthcare technologies;• Discusses the role of big data in smart healthcare, computing techniques for healthcare for medical diagnosis and treatment planning;• Encompasses the ethical and legal challenges of using smart healthcare and medical data.This book serves as a valuable reference for researchers working on smart health technologies. Researchers of medical imaging, artificial intelligence, and data science along with healthcare domain will find it a great resource as well.

This book explores the contemporary dynamics of European football's political economy, mapping the various market and regulatory forces that shape its current position and development.Offering a conceptual framework for understanding political economy as applied to the study of football, this book presents in-depth case studies from Central and Eastern Europe – a region largely underexplored in the research literature – that enable the reader to gain a sense of the rich history and diversity of the economic and social contexts in which European football is shaped. The first part of this book sets out the market structure of football in Europe and considers how key trends of globalisation and hypercommercialisation have been addressed through attempts to incentivise and regulate the football market. It presents a theoretical framework for political economy in football and explores key issues including football and economic development; UEFA's ‘Financial Fair Play'regulations; sponsorship in football; and the socio-economic conditions of hooligan violence. The second part of the book looks more closely at Central and Eastern Europe. Presenting case studies of aspects of political economy in football in Romania, Poland, East Germany, Austria and Hungary (including development of the women's game), this book shows how the economic development of European football has been uneven, not only subject to global trends but also dependent on local historical, political, economic and organisational conditions.Opening up new perspectives on the complex interactions between states, sports organisations, markets and society, this book will be fascinating reading for anybody with an interest in football, the history, politics or business of sport, or political economy as a field of scholarly enquiry.

What Darwin Got Wrong is a remarkable book, one that dares to challenge the theory of natural selection as an explanation for how evolution works---a devastating critique not in the name of religion but in the name of good science. Combining the results of cutting-edge work in experimental biology with crystal-clear philosophical arguments, Fodor and Piattelli-Palmarini mount a reasoned and convincing assault on the central tenets of Darwin's account of the origin of species. This is a concise argument that will transform the debate about evolution and move us beyond the false dilemma of being either for natural selectionor against science.

This open access book is an unprecedented and comprehensive book that delves deeply into the landscape of cancer care in the United Arab Emirates (UAE). This ground-breaking book is set to become a go-to resource for those interested in gaining an in-depth understanding of the status quo of cancer care across the seven emirates. The book, edited by Prof. Humaid O. Al- Shamsi, a leading oncologist in the region and the President of the Emirates Oncology Society, embarks on a compelling journey by meticulously examining the evolving cancer policies, treatment modalities, and innovative approaches while celebrating notable success stories. At the same time, it sheds light on the persistent challenges and unmet needs that continue to impact cancer care in the UAE. Authored by a distinguished group of experts hailing from various sectors within the UAE, the book brings together perspectives from oncology specialists, researchers, healthcare policymakers, patient advocates, and other key stakeholders involved in patient management. It covers a diverse range of topics crucial to cancer care, including early detection, diagnosis, treatment options, supportive care services, survivorship, palliative care, and ongoing research initiatives. In addition to addressing the general aspects of cancer care, this pioneering book focuses on the unique factors and challenges specific to the UAE. It explores the impact of cultural and social factors, healthcare infrastructure, regulatory frameworks, and the integration of technological advancements in cancer management. The book also examines the role of patient support organizations, patient empowerment, and community engagement in tackling the cancer burden. Each chapter in'Cancer Care in the UAE'offers valuable insights into the challenges faced by different disciplines involved in cancer care and provides a roadmap for transformative change. By presenting an overarching vision and strategic outlook for the next generation, the book serves as a catalyst for positive change in cancer care across the UAE. Endorsed by prestigious organizations such as the Emirates Oncology Society and the Emirates Medical Association,'Cancer Care in the UAE'stands as a testament to its credibility and relevance. This comprehensive book will undoubtedly contribute significantly to enhancing cancer care, fostering collaboration among stakeholders, and ultimately improving outcomes for individuals affected by cancer in the UAE and wider region.

After securing popularity in home aquariums, zebrafish have also become an essential animal for biomedical research. Ensuring they are adequately cared for in research settings is therefore of the utmost importance and this book is designed to help laboratories develop good welfare and husbandry practices, refine procedural protocols and engage with ethical obligations. A wide range of topics are addressed, starting with husbandry aspects such as environmental enrichment, nutrition, housing conditions, diseases, health monitoring, biosecurity and larval rearing. More experimental topics are then discussed, such as genotyping, ageing, imaging, behavioural studies, experimental design and statistics. Ethical challenges are also considered through the environmental impact of aquatic facilities and the 3Rs - Replacement, Reduction and Refinement - with a focus on anaesthesia, analgesia, euthanasia and severity assessment. Zebrafish are a shoaling species by nature but this book also takes into account their individual needs by providing: - practical advice from experienced zebrafish caretakers; - bridges between data acquisition and fish welfare; and - the latest guidance for reporting, reproducibility and compliance. This book is written for zebrafish facility personnel and for researchers who are aware of the need for robust care for their zebrafish model. It also provides an unparalleled insight for ethics committee members with the intention to provide the best care possible for this ever-important fish.

'Machine Learning Algorithms Using Scikit and TensorFlow Environments assists researchers in learning and implementing these critical algorithms. Covering key topics such as classification, artificial neural networks, prediction, random forest, and regression analysis, this premier reference source is ideal for industry professionals, computer scientists, researchers, academicians, scholars, practitioners, instructors, and students'--

First published in 1939, Marshal Pilsudski presents a comprehensive biographical history of Józef Klemens Piłsudski (1867-1935). He was a Polish statesman who served as the Chief of State (1918–1922) and first Marshal of Poland (from 1920). He was viewed as the father of the Second Polish Republic, which was re-established in 1918.This book discusses various facets of his life such as birth and parentage (1867- 1877); life in Wilno (1875- 1885); undergraduate life (1885-1887); Pilsudski as P.P.S. agitator; Pilsudski in the Great War (1914); Pilsudski and the New Poland; Pilsudski and Parliament; the Polish crisis (1922); the Pilsudski question; constitutional friction (1928); Pilsudski in Madeira and Poland and his last triumphs. This is an important historical reference work for scholars and researchers of Polish history, World War I history, European history and Military history.

This book describes the development of animal models widely used in biomedical research using step-wise instructions and photographs. Showcasing a wide range of species from zebra fishes, birds, rodents, rabbits, dogs, and pigs, the book includes detailed methodology on how to work with these species and to develop various models. The animal models in neurology including stroke, Alzheimer's disease, Parkinson's disease, and Schizophrenia; Animal models in cancer research, sleep disorders, and cardiovascular diseases are described to meet the understanding of researchers who plan to replicate these models in their laboratories. In depth detailing on the development of targeted gene knockouts and transgenics, implantation models that are used in toxicology studies, and pharmacokinetic studies in pigs and dogs are a highlight. Further, the book describes pharmacologic, chemically induced, surgically induced, microbiologically induced, infectious models, models for neurobehavioral studies, oncology research, and pain research. The book has dedicated sections on anesthesia and analgesia and teaches procedures like venous cut-downs and cannulations in pigs and dogs, and endotracheal intubation, mechanical ventilation and thoracotomy in rodents and will serve as a self-training tool. Concepts in the field of animal model development are explained using examples. Sample size selection, study design, and statistical evaluation of experiments involving laboratory animals are explained to enable young researchers to practically understand the nuances. This book will be a valuable tool for academicians, students, scientists, and veterinarians and will benefit equally who are new to the field and who are already working with laboratory animals.

The Encyclopedia of Fish Physiology is a comprehensive, introductory-level reference work that aims to unite readers in the wonders of this discipline. Fish live in almost every water system on this planet and represent more than half of all vertebrate species alive today. Fish physiology is a massive field of study and can be difficult to penetrate as most texts are written for readers with a post-secondary education in biology. This Encyclopedia aims to capture the interest of a more diverse group of readers, leading readers from core concepts to application in topics as far ranging as reproductive behaviours to surviving sub-zero temperatures. For example, from a foundation of heart anatomy, oxygen transport, and exercise physiology, readers can appreciate the challenges faced by migratory fish as river temperatures increase with climate change. The work aims and showing why biologists around the world choose to study fish physiology and what can be gained from such study. Chapters highlight where physiological systems and processes are conserved across vertebrate groups, which supports the use of fish as a vertebrate model for investigating fundamental problems in physiology and knowledge transfer to the medical field. Other chapters highlight unique specializations and adaptations that allow fish to survive in challenging environments, leading to a deeper appreciation of the natural world. Finally, other chapters demonstrate the consequences of perturbing physiological systems and how this knowledge can empower conservation strategies to protect fish. Much has changed in the field of fish physiology since publication of the previous, Prose award winning, edition. For example, we understand better the impacts of global climate change on the physiological systems of fish, and we have gained a deeper mechanistic understanding of physiological processes through technological advancements such as gene editing with CRISPR, whole genome sequencing, and quantitative'omic` approaches. The new edition will greatly expand the closing thematic section focused on applying fish physiology to real world challenges with topics including ocean acidification, declining habitat quality due to human activities, and the use of zebrafish in biomedical studies on tissue regeneration, neurological disorders and cancer. A new feature of the Encyclopedia is including presentation-ready summary slides of key concepts presented in each chapter, which will be a valuable tool for educators wishing to incorporate the Encyclopedia into class resources. All authors will be encouraged to enhance their chapters with multimedia features such as videos (ex. in fish behaviour chapters) and virtual microscope (ex. chapters on tissue morphology). - Comprehensive single resource on fish physiology that covers a diverse range of topics to educate and fascinate - Written by leading experts in the field, offering topical overviews with a suggested reading list for those wanting to learn more - Structured, accessible chapters include graphical and bulleted summaries that can be used as teaching material - Follows a set template, making the work consistent and easy to navigate

This 2nd edition has been extensively updated and provides comprehensive and current insight into congenital heart diseases, from embryonic development through to clinical features, including human genetics and our current knowledge of the underlying molecular pathways.The book is divided into three parts: an introduction to the development of the heart and its vessels, an overview of the molecular pathways affecting the development of various cardiovascular structures, and a main section focusing on the different types of structural and nonstructural congenital heart diseases, including their clinical features, underlying genetic alterations and insights from animal models and pathways. All chapters have been updated and new chapters added on state-of-the-art approaches including stem cells and organoids, cardiac metabolism, single cell transcriptomics and 3D reconstruction of human heart development. The clinical chapters have been extended and include new sections on diagnostic imaging techniques. Taken together, the book, written by and for clinicians and researchers, provides an integrated and up-to-date resource for all those who want to learn more about both the clinical aspects and the genetic and molecular basis of congenital heart disease.

Předložena kniha představuje vysledky prace současnych českych a slovenskych badatelů, kteři se věnuji problematice proprialni a apelativni slovni zasoby a jejich vzajemnym vztahům.

This book provides a detailed practically focused guide on the latest diagnostic and treatment techniques available for normal pressure hydrocephalus (NPH). Chapters in this work cover the latest developments related to this condition. It introduces how to use a range of diagnostic modalities including magnetic resonance scanning along with how artificial intelligence and machine learning methodologies can be applied. Cases are presented to reinforce how the methods covered can be appropriately applied and guiding principles are also given to assist the reader in developing a thorough understanding of the topic. Potential complications and means of mitigating these are also described. Normal Pressure Hydrocephalus is a detailed practically applicable resource on NPH with insightful contributions covering relevant aspects of pathophysiology, diagnostic modalities and treatment strategies, making it an ideal resource for all medical practitioners whoencounter these patients.

This book provides a comprehensive introduction to the current state-of-the-art in skin cancer, exploring the recent developments, appraising the current evidence and providing future directions with particular emphasis on interdisciplinary collaboration and need for clinical trials. It covers all aspects of skin cancers, including epidemiology, pathology, surgical and non-surgical treatments. It will be a valuable reference for oncologists, dermatologists, dermatopathologists, surgeons, allied health care professionals and other specialists and trainees with a special interest in skin cancer who want to update their knowledge in the multidisciplinary management of such patients. The book will be of interest to medical physicists and radiographers who would like an overview of the current practice in skin cancer. The book can be used by students in medicine, nursing, radiography and medical physics. Features Provides a comprehensive review of all aspects of skin cancer management. Edited by experts in the area, with interdisciplinary and international collaborators. Promotes a'Bigger picture'approach to the topic with multidisciplinary insight.

3D Printing in Radiation Therapy provides practical and comprehensive guidance for the implementation, quality management, maintenance and safe use of a clinical 3D printing programme in the radiation therapy context. Radiation therapy is a safe and effective treatment that can benefit half of all cancer patients, and the introduction of an appropriately planned, managed, and resourced 3D printing programme can increase that benefit in terms of the radiation therapy patient experience, staff engagement, treatment accuracy and improved treatment outcomes, in addition to monetary savings. Key features: Information to aid in selection of suitable 3D printing modalities, materials and software for radiation therapy applications Guidance regarding efficiently and accurately designing, printing and post-processing phantoms, jigs and attachments as well as radiation treatment equipment such as bolus, immobilisation devices, radiation shields and brachytherapy applicators A detailed introduction to comprehensive quality management of the 3D printing service, including documented risk assessments, commissioning methods, 3D printer maintenance, 3D print quality control, reviews, audits and staff training Advice on the potential costs and benefits of the 3D printing service in terms of time, money, space, patient and staff safety, and waste management

The Chlamydomonas Sourcebook, 3rd Edition Cell Motility and Behavior (Volume 3) The gold-standard reference introducing this multidisciplinary science, fully revised and updated with the latest discoveries Originally published as the standalone Chlamydomonas Sourcebook, then expanded as the third volume in a three-part comprehensive gold-standard reference, The Chlamydomonas Sourcebook: Cell Motility and Behavior has been fully revised and updated to include the wealth of new resources for the Chlamydomonas community. Reflecting the significant advancement in the understanding of the role of basal bodies and cilia play in human diseases, this volume employs quantitative proteomics and mass spectroscopy as well as cryo EM tomography and single particle cryo EM. Other topics such as current insights on mitosis and cytokinesis, ciliary assembly and motility, intraflagellar transport, and more help build an understanding of human diseases of the cilium. Cell Motility and Behavior presents the latest in research and best practices, making this a must-have resource for researchers and students working in plant science and photosynthesis, fertility, mammalian vision, and biochemistry; crop scientists; plant physiologists; and plant, molecular, and human disease biologists. - Provides an essential reference to a model species for the study of mechanisms of motility in free living cells - Includes methods for Chlamydomonas motility research - Includes a table listing the known proteins (with NCBI accession numbers) for each structure discussed, and the known mutations that affect each structure and process

This book constitutes the proceedings of the 12th International Congress on Telematics and Computing, WITCOM 2023, held in Puerto Vallarta, Mexico, in November 2023. The 35 full papers presented in this volume were carefully reviewed and selected from 88 submissions. The papers are focused on the topics of artificial intelligence techniques, data science, blockchain, environment monitoring, cybersecurity, education, and software for communications protocols.

Due to the diversity of contexts in which biological computation is performed, a major problem is the selection of functional-oriented techniques for the analysis of biological sequences in a huge environment. The performances of various sequences in biocomputational algorithms are evaluated with variant features to prove their efficiency in real-time environments. Structural and Functional Aspects of Biocomputing Systems for Data Processing provides insight into the structural and functional aspects of biological sequences and the pattern recognition they embed into the data processingcepts, methodologies, and empirical research advances of various biological data mining systems through machine learning approaches. Covering topics such as DNA sequencing, high-speed architecture, and medical image processing, this premier reference source is an essential resource for healthcare professionals, biological systems in biocomputing systems. It extends recent con specialists, industrial professionals, PCR testing professionals, scientists, bioinformaticians, students and educators of higher education, librarians, researchers, and academicians.

This book provides a comprehensive overview of the development of the human central nervous system (CNS) in the context of its many developmental disorders due to genetic, environmental and hypoxic/ischaemic causes. The book contains three general, introductory chapters in which an overview of the development of the human brain and spinal cord, a summary of mechanisms of development as obtained in experimental studies in various invertebrates and vertebrates, and an overview of the causes of congenital malformations are presented. The developmental disorders of the human brain and spinal cord are presented in a regional, more or less segmental way, starting with neurulation and neural tube defects, and ending with developmental disorders of the cerebral cortex. These chapters are abundantly illustrated in colour with carefully chosen clinical case studies with imaging data, and when available, postmortem verification of the developmental disorders involved.In thethird edition, more emphasis has been given to the developmental ontology based on the prosomeric approach, and fetal development. Prenatal diagnosis by ultrasound, MRI and DTI, and classifications of developmental disorders have been updated. A number of new Clinical Cases have been included. Several new co-authors participate in various chapters. The book is intended for advanced medical students, and all those clinicians working with children and adults with developmental disorders of the CNS. Unique to the book is the integration of data from human embryology, experimental and molecular findings in mice in particular, imaging and developmental neuropathology.

Geografia polityczna, pomimo propagowania u swojego zarania dogmatycznych i abstrakcyjnych teorii, dźwigania brzemienia grzechów będącej jej praktycznym zastosowaniem geopolityki oraz wtłaczania w ideologiczny gorset przez pozbawione demokratycznego mandatu rządy, to dziś pełnoprawna, uznana i nieustannie poszukująca kolejnych wyzwań naukowych członkini rodziny geograficznej. Na to wabiące, choć nieokreślone, grząskie i nie dość bezpieczne pole badawcze wkroczył kilkadziesiąt lat temu z niepohamowaną skłonnością do jego dalszej penetracji – przy zachowaniu pokory wobec dokonań poprzedników i szacunku dla nie zawsze chwalebnej tradycji – Profesor Marek Sobczyński. Liczne strumyki refleksji poznawczej i badawczej przenoszone przez pokolenia geografów politycznych ujął on w indywidualny nurt naukowej eksploracji. Materialnym wyrazem docenienia ogromnego i niezwykle cennego wkładu Profesora w rozwój tej dyscypliny naukowej jest niniejsza jubileuszowa książka. Jej struktura odzwierciedla spektrum zainteresowań badawczych autorów zamieszczonych w niej tekstów. Różnorodność podjętych tematów jest zarazem ilustracją wszechstronności naukowej Jubilata.

Civil Engineering and Urban Research collects papers resulting from the conference on Civil, Architecture and Urban Engineering (ICCAUE 2022), Xining, China, 24–26 June 2022. The primary goal is to promote research and developmental activities in civil engineering, architecture and urban research. Moreover, it aims to promote scientific information interchange between scholars from the top universities, business associations, research centers and high-tech enterprises working all around the world.The conference conducts in-depth exchanges and discussions on relevant topics such as civil engineering and architecture, aiming to provide an academic and technical communication platform for scholars and engineers engaged in scientific research and engineering practice in the field of urban engineering, civil engineering and architecture design. By sharing the research status of scientific research achievements and cutting-edge technologies, it helps scholars and engineers all over the world comprehend the academic development trend and broaden research ideas. So as to strengthen international academic research, academic topics exchange and discussion, and promote the industrialization cooperation of academic achievements.

Cilia: From Mechanisms to Disease Part B, Volume 176 of the Methods in Cell Biology series, presents interesting chapters on topics such as The challenge of dissecting gene function in model organisms: tools to characterize genetic mutants and assess transcriptional adaptation in zebrafish, Human LUHMES and NES cells as models for studying primary cilia in neurons, Fixation methods and immunolabeling for cilia proteins in ciliary and extraciliary locations, Single-molecule imaging in the primary cilium, Methods to analyze primary cilia in mouse cardiac lesion model, Methods to study motile ciliated cell types in a zebrafish brain mode, and more. Other sections cover Clinical and Molecular diagnosis in BBS (Bardet-Biedl syndrome), Modeling ciliopathies in patient-derived primary cells, Analysis of motility and mucociliary function of tracheal epithelial cilia, High-speed Super-resolution SPEED Microscopy to study Live Primary Cilium, Methods for siRNA delivery in retina explants, Methods to study primary cilia and autophagy in the brain, and more. Offers a detailed overview of the protocols used to study cilia structure and various aspects of ciliary function Provides an approach to the study of some diseases related to ciliary dysfunction, also known as ciliopathies Written in an accessible style by renowned experts in the field

Cilia: From Mechanisms to Disease, Part A, Volume 175 in the Methods in Cell Biology series, offers a range of techniques and protocols that can be used to study aspects of this interesting cellular organelle both in vitro and in vivo. Sections in this new release include Protocols to induce and study ciliogenesis, Flow Cytometry-Based Approach for the study of primary Cilia, Microscopic observation of human airway ciliary movement using wheat germ agglutinin, Time-lapse imaging of primary cilia behavior with physiological expression of fluorescent ciliary proteins, Evaluation of ciliary-GPCR dynamics using a validated organotypic brain slice culture method, and much more. Other sections cover Studying the morphology, composition and function of the photoreceptor primary cilium in zebrafish, Visualizing Multiciliated Cells in the Zebrafish, Isolation of Ciliary Ectosomes and Analysis of Peptide-mediated Chemotaxis in Chlamydomonas, Using Paramecium as a Model for Ciliopathies, Using organoids to study cilia, Using in vivo cerebellar electroporation to study neuronal cell proliferation and differentiation in a Joubert syndrome mouse model, and more. Offers a detailed overview of the protocols used to study cilia structure and various aspects of ciliary function Provides an approach to the study of some diseases related to ciliary dysfunction, also known as ciliopathies Written in an accessible style by renowned experts in the field

Gene-Environment Interactions in Birth Defects and Developmental Disorders, Volume 152, covers the multifactorial etiology of a variety of developmental disorders, including orofacial clefts, fetal alcohol spectrum disorders, autism, and others. The causes of individual cases of most common birth defects are unknown but likely involve a combination of genetic predisposition and environmental exposures. How these risk factors interact in the genesis of these conditions is still largely unknown and readers will find the latest information and ideas on these disorders, along with discussion of the challenges and opportunities for furthering knowledge in this area. - Presents latest information on gene-environment interactions in birth defects and developmental disorders - Covers multiple animal model systems and human conditions - Includes discussion of the opportunities for discovery in a challenging area of biomedical research

Cilia Signaling in Development and Disease, Volume 155 in the Current Topics in Developmental Biology series, highlights new advances in the field, with this new volume presenting interesting chapters on topics such as Cilia and mTOR signaling, Cilia and Kidney, Extraciliary functions of IFT proteins, Cilia and eye stem cells, Cilia and eye development, Cryo-EM/ET and cilia structure, and Control of protein and lipid composition of photoreceptor outer segments and the implications for eye diseases. - Provides the authority and expertise of leading contributors from an international board of authors - Presents the latest release in the Current Topics in Developmental Biology series - Updated release includes the latest information on Cilia Signaling in Development and Disease

Wnt Signaling in Stem Cells, Development and Regeneration, Volume 153, delves into the biology of Wnt signaling in a wide variety of model organisms. Since their first identification in 1982, Wnt proteins and their downstream effectors have captivated the attention of many researchers in a variety of fields, including developmental biology, cell signaling, structural biology, stem and cancer cell biology and regeneration. Wnt signaling, along with a small number of highly conserved signaling modules including the Hedgehog, FGF, BMP, RA and Notch pathways, orchestrates morphogenesis across all metazoans. Readers will find information on recent discoveries in the Wnt field, including interactions between Wnt and other signaling pathways, and tools and technologies to interrogate the complexity of Wnt signaling. Other chapters cover Wnt signaling in Xenopus neural development, Wnt signaling in hematopoietic stem cell development, Wnt signaling and the maintenance and regeneration of the gut epithelium, Wnt signaling in the skeleton as a basis for Wnt-based regenerative medicine, and Non-canonical Wnt5a-Ror signaling: Insights from human congenital disorders and cancer. - Presents newest findings on the role of Wnt signaling in a variety of tissues and organisms - Illustrates the diverse actions of Wnt signaling in development and disease - Highlight tools and technologies to interrogate Wnt signaling in any biological system

This book, now in an extensively revised and updated second edition, provides a comprehensive overview of both machine learning and deep learning and their role in oncology, medical physics, and radiology. Readers will find thorough coverage of basic theory, methods, and demonstrative applications in these fields. An introductory section explains machine and deep learning, reviews learning methods, discusses performance evaluation, and examines software tools and data protection. Detailed individual sections are then devoted to the use of machine and deep learning for medical image analysis, treatment planning and delivery, and outcomes modeling and decision support. Resources for varying applications are provided in each chapter, and software code is embedded as appropriate for illustrative purposes. The book will be invaluable for students and residents in medical physics, radiology, and oncology and will also appeal to more experienced practitioners and researchers and members ofapplied machine learning communities.

Fish, and particularly zebrafish, have become the fastest-growing segment of the research population. They offer several advantages, in terms of biology and technologies to apply, and thus are employed in numerous research fields. Laboratory Fish in Biomedical Research: Biology, Husbandry and Research Applications for Zebrafish, Medaka, Killifish, Swordtail Fish, Cavefish, Stickleback, Goldfish and Danionella Translucida addresses the relevant and increasing need to collect cutting-edge knowledge on husbandry, maintenance, welfare and experimental protocols of the most common freshwater species under standard laboratory conditions. Provides husbandry and management protocols, devices and water systems Shows strength and weakness of breeding Explores potential scientific applications and experimental protocols. with regards to the most used freshwater fish used for scientific purposes

Cerebrospinal Fluid and Subarachnoid Space: Volume 1: Clinical Anatomy and Physiology is the first book devoted to the comprehensive clinical anatomy of the cerebrospinal fluid for neurosurgeons, neurologists, and neuroscientists. Knowledge of the cerebrospinal fluid (CSF) and the subarachnoid space is necessary for almost all fields of medicine. The book covers a wide swath of topics related to CSF with a focus on topics relevant to neuroscience specialists including researchers, neurologists, neurosurgeons, and neuroradiologists. Topics span from neuroanatomy, neurophysiology, CSF in different disease states and more. Various fresh and fixed cadaveric photographs helps readers obtain a better understanding of anatomy and complications related to CSF. - First comprehensive book devoted to clinical anatomy of cerebrospinal fluid and subarachnoid space - Edited by neuro-anatomists and neurosurgeons, giving it a multimodal perspective - Nerves and vessels color-coded to differentiate from other tissues

DEEP LEARNING FOR TREATMENTS The book provides the direction for future research in deep learning in terms of its role in targeted treatment, biological systems, site-specific drug delivery, risk assessment in therapy, etc. Deep Learning for Targeted Treatments describes the importance of the deep learning framework for patient care, disease imaging/detection, and health management. Since deep learning can and does play a major role in a patient's healthcare management by controlling drug delivery to targeted tissues or organs, the main focus of the book is to leverage the various prospects of the DL framework for targeted therapy of various diseases. In terms of its industrial significance, this general-purpose automatic learning procedure is being widely implemented in pharmaceutical healthcare. Audience The book will be immensely interesting and useful to researchers and those working in the areas of clinical research, disease management, pharmaceuticals, R&D formulation, deep learning analytics, remote healthcare management, healthcare analytics, and deep learning in the healthcare industry.

This book provides the latest information on the significance of zebrafish as an ideal model for researching the biomedical field, with references. This book also focused on the evidence of zebrafish as a model in cardiovascular, neurologic, psychiatric and metabolic research. In addition, the book also includes the research carried out on zebrafish in hepatic, renal, ophthalmic, and ENT related areas. Contributed chapters come from the most prominent laboratories working in this field, which provides a unique perspective on zebrafish models from a wide spectrum of the research community. In addition, the book offers a detailed analysis of the most current research in the area for specific zebrafish models including specific research in the area of skin disorders, endocrine diseases, nutritional disorders, gastrointestinal, hematological disorders and cancer. The compilation of chapters in the volume culminates into a comprehensive and definitive text on zebrafish and its suitability for modeling various diseases, providing a critical resource on the potential attributes of the zebrafish as a pharmacological model. In terms of scope, this book is a useful tool for young researchers, professors and pharmaceutical scientists for understanding the significance of zebrafish as an emerging pharmacological model that can significantly aid in the process of drug discovery and development.

This book offers an original introduction to the representation theory of algebras, suitable for beginning researchers in algebra. It includes many results and techniques not usually covered in introductory books, some of which appear here for the first time in book form. The exposition employs methods from linear algebra (spectral methods and quadratic forms), as well as categorical and homological methods (module categories, Galois coverings, Hochschild cohomology) to present classical aspects of ring theory under new light. This includes topics such as rings with several objects, the Harada–Sai lemma, chain conditions, and Auslander–Reiten theory. Noteworthy and significant results covered in the book include the Brauer–Thrall conjectures, Drozd's theorem, and criteria to distinguish tame from wild algebras. This text may serve as the basis for a second graduate course in algebra or as an introduction to research in the field of representation theory of algebras. The originality of the exposition and the wealth of topics covered also make it a valuable resource for more established researchers.

W opracowaniu celowo wymieniono dużą liczbę osób, w tym takich, których aktywność w ramach ZPNG była niekiedy tylko incydentalna, objawiała się sprawowaniem jakiejś funkcji w lokalnym Kole ZPNG, wygłoszeniem referatu, poprowadzeniem lekcji pokazowej albo wycieczki, a nawet jedynie zabraniem głosu w dyskusji. Przez struktury ZPNG przewinęło się zapewne znacznie ponad tysiąc nauczycieli geografii, większość z nich nie zostawiła utrwalonego drukiem śladu swojej działalności, ale wszystkich tych, o których możemy się dowiedzieć z dokumentów, chcieliśmy przypomnieć. W ten sposób pragniemy oddać hołd polskim nauczycielom geografii, którzy w okresie odbudowy państwa po zaborach, podjęli trud edukacji geograficznej, podnoszenia jej poziomu i metodyki nauczania, szkolenia kadry nauczycielskiej i patriotycznego wychowania młodzieży, a gdy we wrześniu 1939 r. stanęli w obliczu najazdu wrogich sąsiadów, niejednokrotnie za swój trud zapłacili życiem.

The book covers various aspects of the management of keratoconus, which is a leading cause of visual impairment in young adults. It focuses on the epidemiology and risk factors of keratoconus with a special focus on Southeast Asia. Keratoconus affects the quality of vision, thereby affecting the quality of life. While most patients present with defective vision, many are diagnosed accidentally during screening for refractive surgery. The book covers the varied epidemiology of keratoconus across different parts of the world. It discusses many systemic and ocular diseases associated with keratoconus. The book covers the newer diagnostic techniques and various treatment procedures for keratoconus, helping in diagnosing keratoconus in the early stages and closely watching the progression. It discusses various contact lenses to improve vision quality; widely used collagen crosslinking, and its various modifications for halting the progression. It also explains the surgical approach for keratoconus, such as penetrating keratoplasty, lamellar keratoplasty and other lens-assisted procedures. The book is relevant for general ophthalmologists and cornea specialists.

The book provides, in a comprehensive yet concise way, essential information to improve the knowledge and skills of all healthcare providers involved in the treatment of patients with breast cancer. The content does not focus on general information that is widely available via different sources, but on technical aspects – “hands-on” daily practices and principles of radiation oncology that are not included in other books. Drawing on information taught in courses at e.g. the ESTRO School, as well as the authors'broad clinical experience, the respective contributions reflect and share the expertise of leading experts in breast cancer radiation therapy, supported by sound data and evidence. Each chapter includes a short introduction summarizing the evidence in the literature and “pearls” (a short bullet-point summary), and is enriched by tables, figures and illustrations to provide a concise, easy-to-follow and appealing overview. The book, containing also useful electronic supplementary material, will be of interest to a wide range of readers, including radiation oncologists, radiation technicians, medical physicists, and others involved in breast cancer care.

Bioenergetics deals with the very first energy transformation steps performed by living cells. Increased dissipation is the primary effect of processing external energy packages. Enzyme-supported charge separation is the minor but essential outcome for maintaining life. This book explores the usefulness of dissecting the entropy production of enzymes involved in cellular defenses, fermentation, respiration, and photosynthesis, assuming that tightly regulated dissipation is the hallmark of life.Researchers, educators, and students of life sciences can find in this text many examples of how we can use the interdisciplinary approach to study cells'virtuoso ability to connect the microscopic to the macroscopic world. Each chapter is a self-contained unit with a glossary and selected references for further reading.

Genomic and Epigenomic Biomarkers of Toxicology and Disease The latest developments in biomarker research applicable to toxicology and medicine Research on genomic and epigenomic biomarkers is developing rapidly with cutting-edge studies scattered throughout the academic literature, making the status of ongoing scientific activity in this area difficult to ascertain. Genomic and Epigenomic Biomarkers of Toxicology and Disease: Clinical and Therapeutic Actions delivers a comprehensive and authoritative compilation of up-to-date developments in the application of genomic and epigenomic biomarkers to toxicology, disease prevention, cancer detection, therapeutics, gene therapy, and other areas. With contributions from a collection of internationally recognized investigators, this edited volume offers unique insights into current trends and future directions of research in the discussed areas. Combining state-of-the-art information on genomic and epigenomic biomarkers from a range of specialists from around the world, this monograph includes: A thorough introduction to microRNAs as non-invasive biomarkers of toxicity and chemical hazard Comprehensive explorations of extracellular vesicle-associated miRNAs as toxic biomarkers, as well as transcriptomic applications in toxicology and medicine Practical discussions of circulating miRNAs as biomarkers of metal exposure, as well as microRNAs biomarkers of malignant mesothelioma In-depth examinations of the role of noncoding RNAs in innate immune responses perturbed by environmental arsenic with a focus on microRNAs Perfect for researchers, toxicologists, risk assessors, and regulators, Genomic and Epigenomic Biomarkers of Toxicology and Disease: Clinical and Therapeutic Actions will also earn a place in the libraries of graduate students with an interest in biomarkers, toxicology, agriculture, or the environment.

The genetic improvement of fish for aquaculture and related fisheries has seen huge advances over recent years. Building upon the previous two editions of Aquaculture and Fisheries Biotechnology: Genetic Approaches, this 3rd edition offers a presentation of traditional selective breeding, modern genetic biotechnology, genomics, gene transfer and gene editing, and the latest developments in genetic biotechnology such as epigenetics, xenogenesis and genome-wide association study coupled with commercial application, the impact of government regulation and expectations for the future. It provides a firm grounding in relevant aspects of classical genetics, before focusing on particular aspects such as sex reversal and breeding as applied in aquaculture and fisheries. It also explores how more recent molecular genetics, genomics and biotechnology techniques can be used and combined in improvement programmes for fish and aquaculture species. A glossary explains the latest terminology used in biotechnology and genetics. This book will be useful for research scientists and students in marine biotechnology, aquaculture biotechnology, and fish genetics and breeding.

Effective application of tumour treatment with high-dose radiation in radiotherapy provides an increase in the treatment rate and quality of life. Intensity-modulated radiotherapy (IMRT) can conform the radiation dose to the target while minimising the dose given to the surrounding healthy tissue. IMRT was started to be used in radiotherapy about 40 years ago and it is applied in almost all radiotherapy centers today. The IMRT technique, which has been strengthened with new software and applications (such as image-guided radiotherapy and adaptive radiotherapy) has increased the advantages of treatment. This book consists of 18 chapters covering important topics of IMRT.

This book, edited by leading experts in radiology, offers a state-of-the-art overview of the specifics and the added value of dual-energy, multi-energy, and spectral computed tomography (CT). Latest advances and upcoming innovations such as photon-counting detector CT are covered by renown experts in the field. The entire spectrum of clinical applications of dual-energy and spectral CT throughout the body is covered. Book chapters are written by expert authors with a background in physics and radiology and are richly illustrated with high quality figures, graphical illustrations, and tables. The first section covers background issues and the most relevant technical aspects of the technique, including a detailed description of the approaches to dual-energy, spectral and photon-counting CT by different vendors of CT scanners. The second part focusses on the use of dual-energy, spectral and photon-counting CT in daily clinical practice, and individual chapters are devoted to imaging of the brain, cardiovascular system, gastrointestinal tract, abdominal organs, skeletal system, and the chest. The focus of the book ensures that it will be of interest for a multidisciplinary forum of readers comprising radiologists, medical physicists, and other medical professionals and scientists being interested in cutting-edge CT imaging.

Cell-Cell Signaling in Development, Volume 150 covers new approaches and topics surrounding the diversity of animals, with recognized species now in the millions. Remarkably, the many distinct morphologies in the metazoan biosphere are generated by only a small number of genetically-encoded signaling systems that organize cells into patterned tissues, principally, the Wnt, Hedgehog, Bone morphogenic protein, fibroblast growth factor, Notch/Delta, and planar polarity systems whose roles orchestrating morphogenesis are widespread and evolutionarily conserved. Users will find the latest information on these elegant systems, along with conceptual links to signaling in plants and ideas that are emerging from recent progress. - Presents the newest information on signaling proteins of animal development - Covers the processes that make and distribute signaling proteins - Includes coverage of cell-cell interactions that pattern tissues

This book reviews the current state of epigenetics and proteomics of leukemia and introduces the methods that are important to process and evaluate these factors in leukemia. In particular, epigenetic modifiers and their inhibitors in leukemia treatment as well as approaches to the epigenetic treatment of leukemia are covered. Various computational methods for proteome analysis are also described in detail, including 2DE fractionation and visualization, proteomic data processing, image acquisition and data anlaysis, and more. Protein localization in leukemia is also covered, in addition to the future of leukemia therapy. Epigenetics and Proteomics of Leukemia is an ideal book for advanced biomedical scientists and students, medical doctors and students, bioinformatics and health informatics researchers, computational biologists, structural biologists, systems biologists, and bioengineers.

This book constitutes the refereed proceedings of the 22nd IFIP WG 5.5 Working Conference on Virtual Enterprises, PRO-VE 2021, held in Saint-Étienne, and virtually in November 2021.The 70 papers (15 full and 55 short) presented with 5 industrial workshop papers were carefully reviewed and selected from 189 submissions. They provide a comprehensive overview of major challenges and recent advances in various domains related to the digital transformation and collaborative networks and their applications with a strong focus on the following areas related to the main theme of the conference: sustainable collaborative networks; sustainability via digitalization; analysis and assessment of business ecosystems; human factors in collaboration 4.0; maintenance and life-cycle management; policies and new digital services; safety and collaboration management; simulation and optimization; complex collaborative systems and ontologies; value co-creation in digitally enabled ecosystems; digitalization strategy in collaborative enterprises'networks; pathways and tools for DIHs; socio-technical perspectives on smart product-service systems; knowledge transfer and accelerated innovation in FoF; interoperability of IoT and CPS for industrial CNs; sentient immersive response network; digital tools and applications for collaborative healthcare; collaborative networks and open innovation in education 4.0; collaborative learning networks with industry and academia; and industrial workshop.

This 12 volume encyclopedia contains 160 chapters covering a broad range of topics related to marine biology.

This 8-volumes set constitutes the refereed of the 25th International Conference on Pattern Recognition Workshops, ICPR 2020, held virtually in Milan, Italy and rescheduled to January 10 - 11, 2021 due to Covid-19 pandemic. The 416 full papers presented in these 8 volumes were carefully reviewed and selected from about 700 submissions. The 46 workshops cover a wide range of areas including machine learning, pattern analysis, healthcare, human behavior, environment, surveillance, forensics and biometrics, robotics and egovision, cultural heritage and document analysis, retrieval, and women at ICPR2020.