Search

In this new volume in the Cell Biology and Translational Medicine series, we continue to explore the potential utility of stem cells in regenerative medicine. Amongst topics explored in this volume are recent developments in organoids, signaling pathways in regeneration, wound healing, new insights into adipocytes, and regulatory aspects of stem cell commitment, differentiation and organogenesis in both health and disease. One goal of the series continues to be to highlight timely, often emerging, topics and novel approaches that can accelerate stem cell utility in regenerative medicine.

Frontiers in Clinical Drug Research - Anti-Cancer Agents is a book series intended for pharmaceutical scientists, postgraduate students and researchers seeking updated and critical information for developing clinical trials and devising research plans in anti-cancer research. Reviews in each volume are written by experts in medical oncology and clinical trials research and compile the latest information available on special topics of interest to oncology and pharmaceutical chemistry researchers. Volume 9 features reviews on these topics: - Dietary Strategy for Cancer Therapy - Amino Acid Restrictions and Beyond- The Revolutionary Potential of Noble Metal Nanoparticles as Anti-Cancer Agents: State-of-the-Art Applications and Future Perspectives- Algal Polysaccharides as Promising Anticancer Agents- Cardiotoxicity Caused by Doxorubicin and Trastuzumab: Current Understanding for Future Preventive Strategies- Emodin: Anticancer Agent

Targeted Therapy for the Central Nervous System: Formulation, Clinical Challenges, and Regulatory Strategies presents research on various delivery methods of drugs to the central nervous system and brain. This volume examines targeted therapies for neurodegenerative disorders and succinctly outlines the future of drug delivery systems, highlighting significant advancements specifically relating to central nervous system delivery. This book will be of great interest to researchers working in the field of neuroscience and pharmacology as well as clinicians (pharmacists, radiologists, psychiatrists). - Provides a current, thorough means on how drugs are delivered to the neurological system - Figures a connection amongst the physiology of drug delivery pertaining to the central nervous system, fundamentals of drug delivery, and distribution principles - Gives an accounting of clinical trials and regulatory approaches for the formulations targeting brain

Modern advances in organic synthesis require compouds having attractive properties with high percentage of yield. Spirooxindole examines the current state of the art, recent progress and new challenges associated with the development of spirooxindole derivatives for various medicinal applications. Owing to their exceptional properties, these compounds can be used in vaious fields, including chemical and pharma industries, and in clinical research. This book has chapters written by experts in several different areas. It serves as a useful reference book for scientists, industrial practitioners, graduate students, and other professionals in the field of hetrocyclic chemistry, medicinal chemistry, organic synthesis clinical research and chemical sciences.The growing interest among the academics and industrial researchers in the field of organic chemistry and medicinal chemistry is the driving force for the presentation of this edited book. - Consolidates information on each aspect of this novel compound and its applications in various fields, covering the entire spectrum of up-to-date literature citations, current market, and patents - Provides a comprehensive, in-depth description of spirooxindole derivatives as well as multipurpose scaffolds - Highlights green synthesis and nanocatalysis - Describes in-depth various medicinal applications - Covers both synthesis and applications

Higee Chemical Reaction Engineering systematically discusses the fundamentals, principles and methods of molecular mixing and reaction process intensification. The book demonstrates in detail the implementation approach, process and effectiveness of Higee chemical reaction engineering through novel industrial case studies that help industrial technicians to select reaction intensification technology route more scientifically. The book covers the innovation and development process of Higee chemical reaction engineering, hydrodynamics behavior in Higee reactors, equipment design principles and methods, multiphase reaction of liquid-liquid, gas-liquid, gas-solid, gas-liquid-solid and reactive crystallization process intensification principles and effectiveness. It also prospects the future development direction and hot application fields of Higee chemical reaction process intensification. Higee Chemical Reaction Engineering is a systematic summary of several national award and key projects, such as the State Technological Innovation Award, State Science and Technology Advancement Award, National Natural Science Foundation of China, National key R&D Program of China, National''863''Program of China, National''973''Program of China and also some international cooperation. - Handles high gravity process intensification technology - Covers theoretical innovation in multiphase reaction intensified by high gravity - Presents engineering application cases in chemical engineering, materials science, ocean engineering, and environmental engineering - Provides systematic understanding of high gravity process intensification through theories and industrial applications

Chromatin Readers in Health and Disease, Volume 35, a new release in the Translational Epigenetics series, gathers and makes actionable our current understanding of how chromatin readers regulate access to genetic information, and how their aberrant regulation can contribute to human pathologies. Chromatin readers discussed include 14-3-3 Dinshaw, ADD, Ankyrin, BAH, BET, BIR, BRCT, bromodomains and Kac readers, chromodomains and chromobarrel readers, citrullination readers, macrodomains and poly-ADP-ribose readers, MBT, PHD and double PHD, PWWP, SUMO (H4K12) readers, Tudor and TTD, UDR and ubiquitin, WD40, YEATS (crotonyl reader), MBD, SRA, and Methyl-RNA readers.In the book, more than a dozen leaders in the field examine a range of protein readers, their relationship to human disease, and the early therapeutics that act as chromatin signaling factors to treat cancers and Huntington's disease, among other disorders. - Enables researchers and clinicians to understand chromatin signaling mechanisms that regulate gene expression through chromatin readers - Highlights the role of chromatin readers in a variety of human pathologies, as well as early therapeutics that act on chromatin signaling - Includes chapter contributions from international leaders in the field

This book presents extensive and up-to-date information on the anti-proliferative properties of various plant seeds for their application in pharmaceutical industry and medicinal research. This information is imperative for understanding and developing high quality products from the seeds.The book provides insights about anticancer and antitumour activities present in seeds. Different chapters cover the traditional knowledge as well as recent innovations in various seeds, such as prune, pumpkin, grape fruit, sesame, sunflower, bitter gourd, papaya, mango, apple, black plum, cumin, water melon, musk melon, cotton, carambola, pear, cardamon, moringa, wallich, Chinese cabbage, pistachio, etc. and their bioactivities for the applications in cancer and malignancy proliferation. The book introduces the readers to seed as a bioactive compound, and delineates the various health effects. It further explains the relation between the different metabolites and their effect on cell proliferation. Finally the book goes on to explain different seeds and their specific anti-cancer properties. This book is useful for students and researchers of pharmacology, botany and cancer research. It also caters to industry experts in pharmaceutical sciences.

The farming and cultivation of algae can provide sustainable solutions for issues like food security-related problems, costly health-related products, sustainable fuels, and more. However, the use of algae is currently restricted to high-value, low-volume markets, mainly due to the high investment and production costs involved. In recent years, algaculture for food and fuel purposes has begun a transition from R&D and pilot-scale operations to commercial-scale systems. This new book presents the latest technological innovations in algae production, market status, and prospects for algal applications.The book provides an informative overview of different perspectives on the commercial production of algae-based food, health, and high-value cosmeceutical products, providing an institutional framework to support and promote the development and commercialization of algal farming. The book discusses phycotechnology and highlights the current trends and future scope of algal technology. It also presents new information on algal culture conditions and cultivation strategies, including a look at geographic position and local climate as key factors in the implementation of microalgae-based processes. Algal production, marketing strategies, and their commercialization are discussed, as are the industrial applications of algae, focusing mainly on nutraceutical, pharmaceutical, and cosmeceutical applications of microalgae and macroalgae.

There are different types of treatment for breast cancer, including surgery, chemotherapy, radiotherapy, hormone therapy, immunotherapy, and targeted therapy. Deciding on the types of treatment depends on several factors, such as the stage and grade of cancer, biomarkers, and general health of patients. The seventh volume of the “Interdisciplinary Cancer Research” series, entitled “Breast Cancer Treatment: An Interdisciplinary Approach” publishes comprehensive reviews on different treatment opportunities on breast cancer. An update on treatment of triple-negative breast cancer and ductal carcinoma in situ is provided. Ablative breast cancer surgery, radiotherapy, and percutaneous breast cancer treatment are explained. Promising hormone immunotherapy combination as well as targeted therapies for breast cancer is also discussed. This interdisciplinary series is of special value to researchers working on oncology. This is the main concept of Cancer Immunology Project (CIP), which is a part of Universal Scientific Education and Research Network (USERN). This interdisciplinary book will be of special value to researchers and oncologists who wish to extend their knowledge on breast cancer treatment.

Genetics have a role in the presence of breast cancer, while the potential role of the immune system leads to consideration of immunotherapy in the treatment of the disease, particularly in metastatic triple-negative breast cancer. The sixth volume of the “Interdisciplinary Cancer Research” series, entitled “Breast Cancer Genetics, Immunology, and Immunotherapy: An Interdisciplinary Approach” publishes comprehensive volumes on immune and genetic mechanisms of breast cancer diagnosis and prognosis. The role of molecular genetics, interleukins, chemokine receptor, and tumor-infiltrated lymphocytes-TILS in breast cancer are explained. Targeting myeloid determinants, SiRNA loaded in drug delivery nanosystems, nucleic acid and drug dual agent nanoplatforms, and oncolytic virotherapy are also discussed in the treatment of breast cancer, particularly in multidrug resistant and metastatic breast cancer. This interdisciplinary series is of special value to researchers working on immunology, genetics, and practitioners working on oncology. This is the main concept of Cancer Immunology Project (CIP), which is a part of Universal Scientific Education and Research Network (USERN). This interdisciplinary book will be of special value to researchers, oncologists, geneticists, and immunologists who wish to extend their knowledge on breast cancer.

Advances in Novel Phytopharmaceuticals covers the current aspects of the development of novel herbal formulations and summarizes their type of active components, biological activity, applications, and toxicity associated with novel herbal formulations. Such distinct types of novel herbal formulations are described to have remarkable advantages over conventional formulations of plant actives and extracts. The book also covers the various herbal phytoconstituents used for novel drug delivery applications. These novel herbal formulations can be used more uprightly and with enhanced efficacy by incorporating them into modern dosage forms. This can be accomplished by designing novel drug delivery systems for herbal ingredients. This book provides key information for everyone interested in novel phytodrug delivery systems and drug discovery, including medicinal chemists, cosmetic experts, nutritionists, toxicologists, drug formulators, and healthcare professionals. Students, professors, and researchers working in pharmaceutical sciences and beyond will also find the book useful.We will also focus on patent filed, technology transfer, market potential, and regulatory aspects of herbal nanomedicines, if any. Research in this area is still in the exploratory stage, and in the market there are no books available that summarize all the contents of the research. As such, we will try to make our full contribution to this area. This book is the continuation of a first volume and readers and the target audience will gain all the latest knowledge in the subject.Aims and scopeð To understand the basic information and application of phytoconstituentsð To understand the various phytoconstituents-based formulations for disease managementð To understand the herbal drugs used for cosmetic applicationsð To understand the phytodrug delivery systems and their applicationsð To provide detailed knowledge about the technical aspects of formulationð To update readers with the latest research progress in this emerging research areað To provide the details about the patents filed, technology transfer, market potential, and regulatory aspects for the same

This comprehensive work illuminates the molecular foundations and applications of lipases, offering an understanding of their significance in human well-being as well as diseases. Chapter one begins with the meticulous exploration of lipase biochemistry. Chapter two delivers a move beyond digestion to explore the health benefits, metabolic influences, and therapeutic potential of lipases. Chapter three addresses the global issue of obesity. Readers gain insights into the diverse applications and sustainability of lipases, breaking down triacylglycerols in various industries. Probiotic isolates are explored for their role in preventing oxidative rancidity, improving shelf life, and serving as industrial biocatalysts in diverse bioconversion reactions. In Chapter four, the authors present an eco-friendly approach to surfactant synthesis, showcasing the environmental advantages over chemical counterparts. Chapter five delves into the multifaceted roles of lipases. In the last chapter the ubiquitous nature of lipases is underscored. These enzymes, produced by all living organisms, play crucial roles in digestion, transport, and processing of dietary lipids. This chapter navigates through the ubiquity of cellular enzyme lipases in diseased conditions in human, animals and birds and its adverse impact. This book transcends the boundaries of conventional enzymatic literature. This pioneering work promises readers a holistic view of lipase biology, offering a profound understanding of their intricate mechanisms and multifaceted roles in health and disease.

DNA Nanotechnology for Cell Research Comprehensive coverage of DNA nanotechnology with a focus on its biomedical applications in disease diagnosis, gene therapy, and drug delivery Bringing together multidisciplinary aspects of chemical, material, and biological engineering, DNA Nanotechnology for Cell Research: From Bioanalysis to Biomedicine presents an overview of DNA nanotechnology with emphasis on a variety of different applications in cell research and engineering, covering a unique collection of DNA nanotechnology for fundamental research and engineering of living cells, mostly in cellulo and in vivo, for the first time. Broad coverage of this book ranges from pioneering concepts of DNA nanotechnology to cutting-edge reports regarding the use of DNA nanotechnology for fundamental cell science and related biomedical engineering applications in sensing, bioimaging, cell manipulation, gene therapy, and drug delivery. The text is divided into four parts. Part I surveys the progress of functional DNA nanotechnology tools for cellular recognition. Part II illustrates the use of DNA-based biochemical sensors to monitor and image intracellular molecules and processes. Part III examines the use of DNA to regulate biological functions of individual cells. Part IV elucidates the use of DNA nanotechnology for cell-targeted medical applications. Sample topics covered in DNA Nanotechnology for Cell Research include: Selections and applications of functional nucleic acid toolkits, including DNA/RNA aptamers, DNAzymes, and riboswitches, for cellular recognition, metabolite detection, and liquid biopsy. Developing intelligent DNA nanodevices implemented in living cells for amplified cell imaging, smart intracellular sensing, and in cellulo programmable biocomputing. Harnessing dynamic DNA nanotechnology for non-genetic cell membrane engineering, receptor signaling reprogramming, and cellular behavior regulation. Construction of biocompatible nucleic acid nanostructures as precisely controlled vehicles for drug delivery, immunotherapy, and tissue engineering. Providing an up-to-date tutorial style overview along with a highly valuable in-depth perspective, DNA Nanotechnology for Cell Research is an essential resource for the entire DNA-based nanotechnology community, including analytical chemists, biochemists, materials scientists, and bioengineers.

Ganoderma holds significant traditional importance in various ethnic cultures around the world, particularly in China, Japan, and Korea. Many indigenous traditions have incorporated Ganoderma into medicinal practices, being considered a symbol of longevity, vitality, and good health. At present, the taxon is believed to possess various health benefits and is used to treat ailments and promote overall well-being. In this context, the first volume of the book, titled Ganoderma: Cultivation, Chemistry and Medicinal Applications, aims to comprehensively cover the taxonomy, morphological features, domestication strategies, structures of secondary metabolites, and therapeutic prospects of Ganoderma. It may serve as a definite resource for students, researchers, healthcare professionals, traditional medicine practitioners, and enthusiasts.FEATURES Provides a comprehensive classification system for Ganoderma species, highlighting their taxonomy and distinguishing characteristics Delves into the techniques and practices involved in cultivating Ganoderma, offering detailed guidance for individuals interested in growing this valuable fungus Explores the cultural and traditional significance of Ganoderma in various ethnic cultures intertwined with customs, beliefs, rituals, myths, and folklore around the world Investigates the secondary metabolites of Ganoderma, highlighting their implications Examines diverse bioactivities associated with Ganoderma, including antioxidant, hepatoprotective, antidiabetic, prebiotic, anti-inflammatory, anti-arthritis, anticancer, hypolipidemic, and cholesterol-lowering effects This book includes relevant illustrations, diagrams, and images to enhance the understanding of concepts associated with Ganoderma.

Metabolites of Medicinal Plants: Insightful Approaches provides a comprehensive exploration of the bioactive compounds found in medicinal plants and their pharmacological significance. The book covers key topics such as the economics of medicinal and anticancer plants, phytochemistry, therapeutic potential, and advanced applications like nanotechnology-based drug delivery systems and CRISPR-Cas techniques. It also examines the role of these plants in combating diseases like diabetes and metabolic syndrome and their role in traditional medicine systems. This resource is essential for students, researchers, and professionals in phytochemistry, pharmacology, drug discovery, and healthcare practices.Key Features:1. Wide range of topics from medicinal plant economics to pharmacological applications.2. Latest discoveries in plant bioactive compounds and their therapeutic uses.3. Novel drug delivery methods to enhance efficacy.4. Linking genes to metabolites through advanced omics approaches.

This book presents peer-reviewed and selected papers from the 1st International Conference on Recent Advancements in Materials Science and Technology held at Karpagam Academy of Higher Education in Coimbatore, India, on 29-30 January 2024. Experts across the world share the latest developments in their respective fields within materials science, including nanomaterials, biomaterials, optical materials, construction materials, composite materials and more. Additionally, addressing sustainability and the importance of international collaboration, this book serves as an up-to-date and effective resource for researchers, academics, industrialists, and students looking to understand the state of numerous materials science subfields.

This book comprises a detailed overview of nanomaterials for biomedical applications and public health. Nanomaterials show various functions in medicine, sunscreens, electronic device, diagnostics, military applications, photovoltaic cells, paints, imaging, catalysts and drug delivery. In this book carbon Nanotubes/nanowires/nanofibers are explored for tissue engineering applications. Functionalized carbon nanotubes, silica Nanoparticle, silicon quantum dots, metal Decorated Nanomaterials, biogenic metal nanoparticles, magnetic functionalized nanomaterials and nanozymes have been covered for the treatment of bacterial Infections as carriers of gene delivery and for their biological applications. This book also explores nano-biotechnology and its approach for a sustainable future.

Smart and Intelligent Nanostructured Materials for Next-Generation Biosensors provides an up-to-date review of biosensor development and applications, with a focus on incorporating smart and intelligent nanomaterials for improved outcomes. This book covers a range of smart and intelligent nanomaterials for use in biosensors, including two popular classes: MXenes and carbon-based nanomaterials. Later chapters explore a variety of biosensor applications, such as in biomedicine, agriculture, and environment; the reader is thus able to tailor their materials selection to their needs. Smart and Intelligent Nanostructured Materials for Next-Generation Biosensors is a useful reference for materials scientists, biomedical engineers, analytical and biochemists with an interest in smart/intelligent nanomaterials for biosensors. - Details the properties, characterization, and synthesis of smart and intelligent nanomaterials for use in biosensor technology - Explores the potential of MXenes and other carbon-based nanomaterials for application in biosensors - Covers a range of biosensor applications, including biomedical, agricultural, environmental, and in the food industry

This book is the 11th volume of the popular series'Medicinal and Aromatic Plants of the World'. It is a comprehensive compilation of 30 chapters on selected important species representative of India's rich and diverse flora. This collection provides current scientific information highlighting the traditional, contemporary, and prospective uses of both well-known and lesser-known plant species. The volume serves as a bridge between traditional knowledge and modern scientific advancements, providing a critical analysis of this broad interdisciplinary field with a particular focus on India. The chapters cover topics such as the pharmacological properties, biochemical composition, and therapeutic applications of these plants. Readers will find contributions by renowned scholars who delve into the innovative product development stemming from the ancient medicinal plant systems. Particular attention is given to how these plants can contribute to health and wellness in the era of global climate change and pandemics. This book invites readers to face critical questions about the survival and utilization of medicinal and aromatic plants in India. Researchers, scholars, and practitioners in fields of botany, pharmacology, and traditional medicine will find this volume invaluable. It is also an essential resource for anyone interested in botanicals, plant-based nutraceuticals and herbal formulations. Whether you are an academic or a professional working in the field of medicinal plants, this book offers a wealth of knowledge that bridges rich ancient traditions with modern science.

Therapeutic Insights into Herbal Medicine through the Use of Phytomolecules offers a comprehensive exploration of the pharmacological potential of plant-derived compounds. The book provides an in-depth look at the therapeutic applications of phytomolecules in various health conditions. It begins with an analysis of bioactive phloroglucinol compounds and progresses to cover plant-based approaches for managing rheumatoid arthritis, diabetes, cancer, neurological disorders, and antiviral activity. The volume also covers the molecular mechanisms of flavonoids, the preclinical pharmacology of Indian medicinal herbs, and the neuroprotective role of andrographolide in Parkinson's disease. Designed to inform and inspire, this book is ideal for researchers, clinicians, and students interested in the therapeutic potential of natural products.

Nanosized particles explored for therapeutics and diagnosis-related research areas need the latest updated information for budding researchers as well as academicians. Nanomedicine, nanotheranostics, and nanobiotechnology have been contemporary technological tools for diverse biomedical, pharmaceutical, and diagnostic solutions. The present book is divided into two sections.The first section is dedicated to exclusive book chapters related to nanomedicine such as its history, regulatory aspects, scale-up, and regulatory toxicology. Additionally, this section includes chapters focusing on the application domain of nanomedicine for targeted cancer therapy, rheumatoid arthritis management, psoriasis treatment, ocular delivery, topical applications, oral bioavailability enhancement, and pulmonary delivery.The second section is composed of chapters in the area of nanotheranostics and applications of nanobiotechnology. In brief, the latest topics such as gold nanoparticles in diagnostics and therapy, nanoparticles for siRNA delivery, carbon nanotubes for gene delivery, nanoparticles for vaccine delivery, nanobiotechnology in cell-based nanomedicines, nanotechnology in regenerative medicine, and nanocarriers in delivery of proteins and peptides are complied.KEY FEATURES A total of 26 emerging topics are covered in the book on cutting-edge research areas at the multi-disciplinary level. The chapters focus on fundamentals and applications, making the book attractive for beginners as well as experts. The chapters are written by well-known experts of the field in a simple scientific style with figures, schemes, and illustrations.

Smart drug delivery refers to a targeted drug delivery or precision drug delivery system that allows drugs to be administered to a specific location in the body or at a specific time with enhanced precision and control. This approach has several advantages, including maximizing the therapeutic effects of a drug while minimizing side effects.This book presents various stimuli-responsive micro- and nanomaterials for pharmaceutical industries. This volume: Covers the global market perspective of micro- and nano-smart materials in pharmaceutical industries. Details various processing routes. Discusses mechanisms for target release. Addresses applications in oral drug delivery, anticancer agents, anti-tumor drug delivery, and drugs for management of infection. This reference work is written to support researchers in the fields of materials engineering and biotechnology with the goal of improving the diagnosis and treatment of disease and patient quality of life.

Environmental pollution is a worldwide concern now. A major section of the world population is struggling for drinking water. Polluted soil is resulting into low agricultural productivity and thus creating challenges in the way of sustainable livelihood of a large section of human population. Biological treatment can offer both green solutions for wastewater treatment and resource recovery as well. Like algal-based systems can be utilized for wastewater treatment and production of biofuels from the biomass grown on the wastewater. Bio-based nanomaterials have been extensively studied for their employability in the health care, process optimization, water resource management, dealing with environmental pollutants, biosensors, and many others. Bioprospecting of novel biological agents, bio-based products, and bioresource recovery are paving the way for sustainable development as they are providing local solutions for a number of problems.In this proposed book, we start with the introduction to bio-nanotechnological principles and later on discuss bio-based nanomaterials employability for a diverse range of applications from environment to energy to health care. This book provides with current trends in bio-nanotechnology for anthropogonic purposes, prospects, challenges, and way forward.

Advances in Virus Research serial highlights new advances in the field with this new volume presenting interesting chapters. Each chapter is written by an international board of authors. - Provides the authority and expertise of leading contributors from an international board of authors - Presents the latest release in Advances in Virus Research serials - Updated release includes the latest information on Microbes at bio/nano interfaces

Current Molecular Targets of Heterocyclic Compounds for Cancer Therapy discusses recently developed treatments based on molecular targets which are genetically altered in cancer cells and are essential for tumor development and survival. Considerable research effort has been devoted to the development of targeted drugs that inhibit the action of pathogenic kinases, and clinical studies performed so far have validated the positive effects of kinase inhibitors for cancer treatment. Each chapter discusses a molecular target, such as ALK2, ATR, CK, Src-Abl, EGFR, Fyn-Blk-Lyn, IGFs, and PAK1. The book's chapters are written by experts who actively work on the targets to help readers fully understand how they can be used. This is a valuable resource for cancer researchers, oncologists, graduate students and members of the biomedical field who are interested in the potential of novel cancer therapies based on molecular targets. - Discusses recently discovered molecular targets for cancer therapy - Brings updated literature of heterocyclic compounds, an important construction motif for the development of new anticancer drugs - Encompasses comprehensive compilation of recently introduced anticancer drugs in the market and their health outcomes and pharmacoeconomics

This unique book provides a comprehensive introduction to the multifaceted realm of functionalized magnetic nanoparticles in the field of theranostics, exploring the fundamental concepts, synthesis methods, characterization techniques, and potential applications. In recent years, the intersection of nanotechnology and medicine has ushered in a new era of therapeutics and diagnostics. Among the myriad nanostructures, magnetic nanoparticles (MNPs) have emerged as versatile candidates with immense potential for theranostic applications. Their unique combination of magnetic properties and functionalization capabilities has paved the way for innovative approaches in both the diagnosis and treatment of various diseases. Understanding the synthesis, characterization, and manipulation of these MNPs is essential for harnessing their full potential in theranostics. Advances in nanotechnology have enabled precise control over their size, shape, and surface chemistry, allowing for tailored functionalities to suit specific biomedical applications. From superparamagnetic iron oxide nanoparticles (SPIONs) to magnetic nanorods and beyond, the diverse landscape of MNPs offers a rich playground for innovation. The convergence of diagnosis and therapy is facilitated by functionalized MNPs; their magnetic properties render them invaluable tools for imaging modalities such as magnetic resonance imaging (MRI), offering high-resolution anatomical and functional information for disease detection and monitoring. Simultaneously, functionalizing MNPs with targeting ligands, therapeutic agents, or stimuli-responsive moieties empowers them to actively engage in targeted drug delivery, hyperthermia, or magnetic manipulation of biological processes. This synergistic approach exemplifies the essence of theranostics—combining therapy and diagnostics to achieve personalized and precise medical interventions. The book discusses the challenges ahead, including the translation of functionalized MNPs from bench to bedside, which necessitates rigorous preclinical and clinical evaluations to ensure safety, efficacy, and biocompatibility. Moreover, the complex interplay between nanoparticles and biological systems demands a multidisciplinary approach, bridging the gap between materials science, biology, and clinical medicine. Regulatory hurdles, scalability issues, and ethical considerations further underscore the need for concerted efforts and strategic collaborations in the development and commercialization of MNP-based theranostic platforms. The readers will find that “Functionalized Magnetic Nanoparticles for Theranostic Applications” comprehensively covers the chemical, structural, and biological properties of functionalized magnetic nanoparticles for theranostic applications as well as most of the challenges. Audience This unique reference book will be of great value to materials engineers, polymer scientists, and technologists working in the electronic, electrical, and biomedical industries. It will also be of great use to graduate, postgraduate, and engineering students working in materials and polymer science.

The book covers the basics of microfluidics, current applications in areas such as formulation, drug delivery, drug screening and development, monitoring and diagnostics, and case studies from a teaching perspective to undergraduate and postgraduate students, allowing application of the content in a flipped classroom. Multiple choice questions are included at the end of each chapter. All chapter authors are pioneers and world leaders. This is an ideal book for students, researchers, and industry professionals working on microfluidics in the pharmaceutical sciences.

Carbon-Based Nanocomposite Applications and Microelectronic Technologies covers the fundamentals of carbon-based nanomaterials (CNMs) and their potential for technological and industrial applications. Written by a leading expert, this volume gives thorough coverage of bio-nanotechnology and biomedical applications of novel carbon nanomaterials and explores the development of microelectronics technologies and nanocomposites. Key features: · Covers a range of biotechnological applications, from human toxicological assessment of carbon nanotubes at biointerfaces to electrochemiluminescence (ECL), optical and glucose biosensors. · Addresses issues of biosafety, biocompatibility and biodegradation.· Assesses the potential for future CNMs-enzyme conjugates for potential use in cancer treatment. ·Full references can be found via the Support Material: www.routledge.com/9781032636061This book provides a crucial study of technological and biomedical applications of CNMs and will be important reading for researchers and industry professionals working in the fields of advanced nanoelectronic materials, biotechnology and nanomedicine.

This book addresses the pressing problem of drug resistance in the treatment of breast cancer. It provides a comprehensive understanding of the complex mechanisms underlying drug resistance and presents the latest advances in therapeutic approaches to overcome this enormous challenge. The book begins with an introduction to the biology of breast cancer, treatment modalities and the mechanisms of drug resistance. This includes the principles of drug resistance in targeted, immune-, endocrine and chemotherapy. In the following sections, the authors present innovative strategies to overcome drug resistance and new research directions, among others the role of the microbiome in drug resistance, molecular profiling of patients for personalized medical care, and new drug delivery systems. Finally, the book concludes with a discussion of the differences in the prevalence and treatment success of breast cancer between high- and low-income countries. This book is an informative resource for students, researchers, and clinicians in the field of breast cancer research and oncology in general.

Volume 1 of Computational Approaches in Bioengineering—Computational Approaches in Biotechnology and Bioinformatics—explores many significant topics of biomedical engineering and bioinformatics in an easily understandable format. It explores recent developments and applications in bioinformatics, biomechanics, artificial intelligence (AI), signal processing, wearable sensors, biomaterials, cell biology, synthetic biology, biostatistics, prosthetics, big data, and algorithms. From applications of biomaterials in advanced drug delivery systems to the role of big data, AI, and machine learning in disease diagnosis and treatment, the book will help readers understand how these technologies are being applied across the areas of biomedical engineering, bioinformatics, and healthcare. The chapters also include case studies on the role of medical robots in surgery and the determination of protein structure using genetic algorithms. The contributors are all leading experts across multiple disciplines and provide chapters that truly represent a complete view of these state-of-the-art technologies.FEATURES Covers a wide range of subjects from biomedical engineering like wearable devices, biomaterials, synthetic biology, phytochemical extraction, and prosthetics Explores AI, machine learning, big data analysis, and algorithms in biomedical engineering and bioinformatics in an easily understandable format Includes case studies on the role of medical robots in surgery and the determination of protein structure using genetic algorithms Discusses genetic diagnosis, classification, and risk prediction in cancer using next-generation sequencing in oncology This book is ideally designed for biomedical professionals, biomedical engineers, healthcare professionals, data engineers, clinicians, physicians, medical students, hospital directors, clinical researchers, and others who work in the field of artificial intelligence, bioinformatics, and computational biology.

Bio-organic Amendments for Heavy Metal Remediation: Water, soil and plant focuses on these core continuum media to explore remediation options using microbial, organic and combined approached. A volume in the Plant Biology, Sustainability and Climate Change series, this book offers a comprehensive view of techniques and approaches for addressing contamination by heavy metals.As anthropogenic activities increasingly negatively impact natural resources, there has been significant disturbance of water, soil, and plant continuum due to the accumulation of heavy metals. The bioaccumulation of heavy metals in the food chain could pose life-threatening effects on plants as well as humans, and there is need to find effective and sustainable remediation options. The application of bio-organic amendments could serve as a sustainable solution to this problem.Employing microbial, organic and combined approaches to reduce the accumulation of heavy metals in the food chain ultimately would lead to the production of safe food for humans.This book provides a comprehensive view of the challenge with a focus on the bioremediation of heavy metals contamination using ecotechnological approaches to protecting the soil, water and plant continuum. - Highlights remediation techniques/approaches for heavy metals under water, soil and plant continuums - Presents case-studies for real-world insights as well as current practices - Includes regulatory aspects for ensuring safe implementation

Extensive experimentation and high failure rates are a well-recognized downside to the drug discovery process, with the resultant high levels of inefficiency and waste producing a negative environmental impact. Sustainable and Green Approaches in Medicinal Chemistry 2e reveals how medicinal chemistry can play a direct role in addressing this issue. After providing essential context to the growth of green chemistry in relation to drug discovery, the book goes on to identify a broad range of practical techniques and useful insights, revealing how medicinal chemistry techniques can be used to improve efficiency, mitigate failure and increase the environmental benignity of the entire drug discovery process. Drawing on the knowledge of a global team of experts, Sustainable and Green Approaches in Medicinal Chemistry, Second Edition encourages the growth of green medicinal chemistry, and supports medicinal chemists, drug discovery researchers, pharmacologists and all those in related fields across both academia and industry in integrating these approaches into their own work. This second volume of the second edition includes the development of nanoparticles and nanocomposites, as well as the application of ultrasound and microwave-induced methods; studies solventless synthesis; defines the role of steroids; studies reactions in aqueous solution; identifies enzyme-mediated reactions; investigates ionic liquids and deep eutectic solvents; explores natural products; investigates solid supports; realizes the effects of salts; focuses on combinatorial chemistry; develops one-pot methods; analyzes multi-component reactions; investigates dipole moment values; and examines computer-assisted methods. - Highlights the need for adoption of sustainable and green chemistry pathways in drug development - Reveals risk factors associated with the drug development process and the ways sustainable approaches can help address these - Identifies novel and cost effective green medicinal chemistry approaches for improved efficiency and sustainability

This inter-disciplinary volume provides information on anticancer medicines derived from marine organisms. Eight edited reviews extensively list the variety of organisms including marine plants, sponges, cnidarians and fish. Emphasis is placed on the source of the compounds, their structure and mechanism of action. Anticancer peptides from sponges are covered in a dedicated chapter. The specific biology and ecology of marine organisms yielding these anticancer compounds is also highlighted where appropriate. All chapters include detailed references for advanced readers.This volume is a standard text-cum-reference for teachers, students and researchers of various disciplines such as Biomedical Sciences, Pharmaceutical Sciences, Marine Biology, and Fisheries Science, it also serves as a guide to marine anticancer compounds for professionals in the pharmaceutical industry who are involved in the development of new marine-derived anticancer drugs.

This handbook provides comprehensive coverage of the role of proteases and the associated biochemical pathways in cancer development and metastasis. Proteases make up about 2% of the human genome and play a critical role in the tumor microenvironment. Handbook of Proteases in Cancer: Cellular and Molecular Aspects introduces the major classes of proteases and the signal transduction mechanisms associated with cancer initiation and progression. It discusses the role of inflammation and immune responses in proteases-induced cancer. The book covers cancer-induced gene expression and apoptotic and necrotic pathways in cancer. This is useful for researchers and professionals in cancer research, biochemistry, and physiology. Key Features• Provides insights on the roles of proteases and anti-proteases in the tumor microenvironment.• Covers various cancer-induced apoptotic and necrotic pathways.• Discusses the mechanisms by which proteases induce an increase in inflammation, immuneresponse, and gene expression.• Covers the function of protease-activated receptors in cancer.• Reviews the different gene expression pathways and the ways they become erratic duringprotease-induced cancer.

Heterocyclic compounds are vital in synthetic chemistry, pharmaceuticals, agrochemicals, and materials science. The concept of S-heterocyclic compounds revolves around organic compounds that contain heterocyclic rings, and sulfur (S) is one of the heteroatoms within the ring structure. S-enabled heterocycles have emerged as one of the key classes of heterocycles and have attracted tremendous attention attributed to their identity as ‘privileged pharmacological structures'across natural products and highly active pharmaceutical agents. This edited volume reports the latest developments in practical and selective reactions and methods and provides details of the structural diversity of heterocycles. Together, the chapters provide a comprehensive view of the diversity of methods, properties, and the variety of applications in the construction of S-heterocycles. Divided into four parts, the book covers in part one the chemistry, synthesis pathways, property profile, and applications of thiazoles, and includes five chapters. Part two details thiadiazoles and part three thiopyrans, thiazine, and thiazepine. Lastly, part four focuses on thiophenes. This volume will be of immense help to academicians, researchers, and students pursuing research and looking at the future of heterocyclic chemistry.

Nanophototherapy: Preparations and Applications provides a comprehensive overview of the various multifunctional nanoparticles used for phototherapy, with an emphasis on fundamental nanotechnology and the latest research of photothermal therapy (PTT) and photodynamic therapy (PDT). The different types of phototherapeutic nanomaterials are thoroughly described, along with their structural features and synthesis. This is the first book to cover nanomaterial-based phototherapy for both cancer and bacterial infections. It is an essential resource for researchers, academics, and professionals interested in the potential of multifunctional nanomaterials for therapeutic applications. - Overviews the types, structural features, design, and fabrication of advanced nanomaterial-based phototherapy of cancer and microbial infections - Provides fundamentals and reviews the latest research on nanomaterial-based phototherapy for the treatment of cancer and bacterial infections - Features definitions, synthesis, and characterization of various nanomaterials, such as NIR-based metals, photosensitizer-loaded nanomaterials, polymer nanoparticles, and more

Marine Biopharmaceuticals: Scope and Prospects is a collaboration of experts in pharmacology, biology and biochemistry with a focus on Marine Bioprospecting. The book provides an in-depth exploration of promising pharmaceutical compounds found in various marine biota and their therapeutic applications. The comprehensive contents cover marine ecosystems, marine biopharmaceutical, and delve into the chemistry and therapeutic applications of compounds from diverse marine organisms such as seaweeds, sponges, cnidarians, bryozoans, worms, shellfish, tunicates, and fishes.The chapters also highlight approved and marketed marine biota-derived drugs and marine biota-derived drug candidates currently under clinical trials. Marine biopharmaceutical compounds targeting SARS-CoV-2 are also covered, reflecting the latest developments in the field. The editors conclude the book by advocating for the establishment of professional grade Marine Biopharmacy courses at university level to contribute to this emerging field.This reference serves as a guide for researchers and instructors in disciplines such as Pharmaceutical Sciences, Marine Biology, Marine Microbiology, Marine Biochemistry, and Marine Biotechnology. Moreover, it is positioned as a standard reference for libraries in colleges and universities, offering critical insights for drug companies engaged in the development of new drugs from marine biopharmaceuticals.

This book provides an in-depth overview of marine greens and their environmental and biotechnological applications. It addresses concepts such as the niche adaptation strategies of marine greens in their natural habitats, as well as their global distribution, and factors affecting their distribution and proliferation.Marine greens are posited as an alternative to fossil fuels, mitigating global climate change and thereby fostering future environmental sustainability. In addition, the book explains the remediation of xenobiotics, wastewater, microplastics, marine debris and marine green contamination. Expert authors from around the world explore the industrial and agricultural applications of marine greens in the production of enzymes and marine bioenergy, and what is needed to improve its production potential.This is important reading for government and non-governmental organizations as well as industries and research institutions looking for ways to combat current industrial and environmental challenges.

Introducing Smart Nanocarrier for Effective Drug Delivery—a pioneering guide that delves into the realm of nanotechnology and its revolutionary impact on drug delivery systems. This comprehensive volume offers a deep understanding of smart nanocarriers'principles, design, and applications, setting it apart as a cutting-edge resource in the field.Nanotechnology has transformed drug delivery, enhanced therapeutic outcomes, and minimized side effects. This book provides a concise yet thorough overview of this dynamic landscape, elucidating key concepts and methodologies. It covers foundational principles and explores advanced strategies for targeted drug delivery, personalized medicine, and combination therapy.KEY FEATURES In-depth exploration of various types of nanocarriers, from liposomes to polymeric nanoparticles, highlighting their unique attributes. Detailed examination of smart stimuli-responsive nanocarriers that release drugs at precise locations and times. Comprehensive analysis of the latest advancements in nanomedicine, including nanodiagnostics and theranostics. Case studies illustrating real-world applications and success stories of nanocarrier-enhanced drug delivery. Smart Nanocarrier for Effective Drug Delivery is an invaluable resource for researchers, practitioners, and students in pharmaceutical sciences, nanotechnology, and drug delivery. It offers a roadmap to harnessing the potential of nanocarriers for enhancing therapeutic efficacy while minimizing adverse effects. This book equips readers with the knowledge to navigate the rapidly evolving landscape of smart nanocarrier technology, making it an essential addition to their professional toolkit.

This book highlights the role and mechanism of different metal nanocomposites toward oxidative stress-induced metabolic disorders including metabolic pathways affected by oxidative stress and related pathophysiology. The book includes an illustrative discussion about the methods of synthesis, characterization, and biomedical applications of metal nanocomposites. It focuses on the therapeutic approaches for metabolic disorders due to oxidative stress by nano delivery systems. Moreover, the book includes chapters on nanotherapeutic approaches toward different diseases, including diabetes mellitus, obesity, cardiovascular disorders, cancers, and neurodegenerative diseases such as Alzheimer's disease and Parkinson's disease. This book is aimed at researchers and graduate students in nanocomposites, nano delivery systems, and bioengineering.Features Discusses nanocomposites in the field of therapy for diabetes, obesity, cardiovascular disorders, neurodegenerative diseases, and cancers Details the pathophysiology of oxidative stress-induced metabolic disorder Explains mechanisms of the antioxidant potential of metal nanocomposites Discusses pathways to elucidate the therapeutic activity Reviews specific and precise applications of metal nanocomposites against lifestyle-induced disorders

This new 2-volume set offers a comprehensive review of more than 80 medicinal plant species, providing information on the bioactives and pharmacology of these beneficial plants. It describes the structures of the secondary metabolites found in these plants, the functions of these compounds in human and plant biology, and the biosynthesis of these compounds.Each chapter begins with a brief introduction about the species. The chapters then delve into the bioactive phytochemicals from the plant along with its chemical structure. The published literature on pharmacological activities on that species is comprehensively reviewed. A wide array of the biological activities and potential health benefits of the medicinal plant (which include antiviral, antimicrobial, antioxidant, anti-cancer, anti-inflammatory, and antidiabetic properties as well as protective effects on liver, kidney, heart and nervous system) are given.Phytochemical Composition and Pharmacy of Medicinal Plants aims to be valuable source book for scientists, researchers, industry professionals, faculty and students for the development of new and effective drugs from medicinal plants.

Flavonoids are well-known plant metabolites that have extraordinary properties that can be used for treating health issues. The pharmaceutical importance of flavonoids is due to their anti-depressant, anti-viral, anti-inflammatory, and antioxidant capacities. They are also of great importance when it comes to neuroprotection, cardiovascular disorders, and many types of cancer. Flavonoids are also easily available and produce less harmful side effects than some conventional therapeutics.This new volume examines the growing use of flavonoids for prevention and treatment of diseases and discusses their beneficial mechanisms. Chapters in the volume address diverse uses as anti-aging tools, as anti-inflammatory agents, for treating pregnancy-induced disorders, as a promising tool to combat infection of Covid-19, etc. The book explores their specific therapeutic antiviral potentials, the gene expression by flavonoids, and the role of flavonoids in agriculture.

With chapters written by highly skilled and experienced scientists and researchers, this book provides valuable information on specific nutraceuticals that offer benefits in the prevention, management, and treatment of cancer. The volume covers the efficacy, safety, and toxicological aspects of nutraceuticals and addresses various novel drug delivery systems.Key features: Covers the applications and implications of nutraceuticals for cancer prevention and treatment, including prostate cancer, lung cancer, breast cancer, skin cancer, colon cancer, liver cancer, cervical cancer Discusses the principles of nanotechnology in the delivery of nutraceuticals for the prevention and treatment of cancer Explores the role of antioxidants, flavonoids, and phytochemicals in cancer prevention

The 5th World Congress on Genetics, Geriatrics and Neurodegenerative Diseases Research (GeNeDis 2022) focuses on the latest major challenges in scientific research, new drug targets, the development of novel biomarkers, new imaging techniques, novel protocols for early diagnosis of neurodegenerative diseases, and several other scientific advances, with the aim of better, safer, and healthier aging. This volume focuses on the sessions from the conference on Molecular Biology, Chemical Biology, and Cellular Biology.

This book contains eight chapters discussing curcumin and its role in health and disease. Chapter One evaluates curcumin's role in cancer prevention. Chapter Two reviews curcumin's function as a natural systemic disease modulator. Chapter Three looks at the effects of curcumin supplantation and exercise training on Alzheimer's disease and age-associated cognitive decline. Chapter Four focuses on the antiviral effects of curcumin, with a special emphasis on COVID-19. Chapter Five examines green extraction techniques for curcumin, synthetic approaches, as well as its anti-inflammatory, anti-oxidant, and anti-neoplastic effects. Chapter Six reviews the possible effects of immune responses to the preventive combined effects of exercise training and curcumin supplementation in chronic disease. Chapter Seven is a mini review of the essential therapeutic effects of curcumin. The eighth and final chapter examines the promises and challenges of curcumin in medical research.

A Handbook of Artificial Intelligence in Drug Delivery explores the use of Artificial Intelligence (AI) in drug delivery strategies. The book covers pharmaceutical AI and drug discovery challenges, Artificial Intelligence tools for drug research, AI enabled intelligent drug delivery systems and next generation novel therapeutics, broad utility of AI for designing novel micro/nanosystems for drug delivery, AI driven personalized medicine and Gene therapy, 3D Organ printing and tissue engineering, Advanced nanosystems based on AI principles (nanorobots, nanomachines), opportunities and challenges using artificial intelligence in ADME/Tox in drug development, commercialization and regulatory perspectives, ethics in AI, and more. This book will be useful to academic and industrial researchers interested in drug delivery, chemical biology, computational chemistry, medicinal chemistry and bioinformatics. The massive time and costs investments in drug research and development necessitate application of more innovative techniques and smart strategies. - Focuses on the use of Artificial Intelligence in drug delivery strategies and future impacts - Provides insights into how artificial intelligence can be effectively used for the development of advanced drug delivery systems - Written by experts in the field of advanced drug delivery systems and digital health