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ADVANCES in NOVEL FORMULATIONS for DRUG DELIVERY The 27 chapters describe novel strategies for drug/nutraceutical delivery and embrace the development of formulations with herbal ingredients, while also highlighting disease therapeutics. Drug delivery technology has witnessed many advancements purported to cater to the customized needs of its ultimate beneficiaries—the patients. Today, dosage forms are not confined to conventional tablets, capsules, or injectables, but have evolved to cover novel drug carriers such as particulates, vesicles, and many others. Nanotechnological advancements have played a major role in this paradigm shift in ways of delivering active pharmaceutical ingredients. A new dimension in the use of food as medicine has also gained prominence in recent years. A portmanteau of nutrition and pharmaceuticals is “nutraceuticals,” also known as functional foods and dietary supplements. The technologies which were earlier included in drug delivery have been attempted for the delivery of nutraceuticals as well. Herbal actives have received increased attention due to their low risk-to-benefit ratio. The field of drug delivery is quite dynamic in nature, as witnessed by its evolution from conventional dosage forms to nanotechnology-assisted drug products. A variety of formulations via different drug delivery routes have been developed to treat/cure/mitigate diseases or disorders. This book, comprising of 27 chapters, is a thorough compilation of information relevant to drug delivery systems with an emphasis on products based on nanotechnology. Audience Researchers, scientists, industry professionals, formulators and product developers, regulatory agencies in a variety of settings including novel drug delivery research laboratories, pharmaceutical, and pharmacy industries, biomedical sciences, food and nutraceuticals manufacturers, and nanotechnology.

Computational Models in Biomedical Engineering: Finite Element Models Based on Smeared Physical Fields: Theory, Solutions, and Software discusses novel computational methodologies developed by the authors that address a variety of topics in biomedicine, with concepts that rely on the so-called smeared physical field built into the finite element method. A new and straightforward methodology is represented by their Kojic Transport Model (KTM), where a composite smeared finite element (CSFE) as a FE formulation contains different fields (e.g., drug concentration, electrical potential) in a composite medium, such as tissue, which includes the capillary and lymphatic system, different cell groups and organelles. The continuum domains participate in the overall model according to their volumetric fractions. The governing laws and material parameters are assigned to each of the domains. Furthermore, the continuum fields are coupled at each FE node by connectivity elements which take into account biological barriers such as vessel walls and cells. - Provides a methodology based on the smeared concept within the finite element method which is simple, straightforward and easy to use - Enables the modeling of complex physical field problems and the mechanics of biological systems - Includes features that are illustrated in chapters devoted to applications surrounding tissue, heart and lung - Includes a methodology that can serve as a basis for further enhancements by including additional phenomena which can be described by relevant relationships, derived theoretically or experimentally observed in laboratories and clinics

Encyclopedia of Surgery organizes researchers from around the world in surgery and related disciplines and maintains an up-to-date reference work for readers worldwide.

International Conference on Pharmaceutical Sciences and Technology (PST 2019)Selected, peer reviewed papers from the International conference and exhibition on Pharmaceutical Sciences and Technology (PST 2019), June 18-19, 2019, Bangkok, Thailand

This book discusses the current research concepts and the emerging technologies in the field of stem cells and tissue engineering. It is the first authoritative reference documenting all the ways that plastic surgical practice and regenerative medicine science overlap or provide a road map for the future of both specialties. The Editors have provided a valuable service by gathering in one place the leading voices in these two fields in clear and concise manner. Divided into five parts, the book opens with a description of the elements of regenerative medicine including definitions, basic principles of soft and bone tissue regeneration, biomaterials and scaffolds. Current research concepts are explored in the second part of this book, for example mechanotransduction and the utility of extracellular vesicles. In the third part, the editors present the emerging technologies and highlight the novel perspectives on bionic reconstruction and biomimetics in surgery and regenerative medicine. Part four deals with translational aspects including practical information on moving scientific findings from bench to bedside. The final part then describes in detail applications in clinical plastic surgery. Written by leading experts this book is an invaluable resource for researchers, students, beginners and experienced clinicians in a range of specialties.'In your hands is a comprehensive encyclopedia of two rapidly converging fields. Drs Duscher and Shiffman have done an outstanding job of highlighting the interdependent relationship between plastic surgery and regenerative medicine. Ultimately, this is to the benefit of both fields.'- Geoffrey C. Gurtner, MD, FACS Johnson and Johnson Distinguished Professor of Surgery Professor (by courtesy) of Bioengineering and Materials Science Inaugural Vice Chairman of Surgery for Innovation Stanford University School of Medicine

The fifth edition of this well-received book contains all the latest information on surgical techniques in abdominal hernia surgery and has been updated to reflect progress in robotic hernia surgery and minimally invasive approaches, as well as new materials used such as fully resorbable synthetic meshes. With chapters on management of complications and laparoscopic repair, among others, the book also contains newly-added accounts of the Milos technique, laparoscopic primary closure of defects and mesh.For each of the surgical techniques described the reader will find information on pre- and post-operative management, instructions on theatre set-up and patient positioning, an account of the incision and access, as well as detailed operative steps and closure, and finally tips and pitfalls. From financial aspects to operative techniques and materials, this book provides a very comprehensive account of abdominal hernia management. Richly illustrated to demonstratethe surgical procedures in detail this book is written by a team of world leaders in herniology. This is an indispensable guide to herniologists and hernia surgeons, worldwide.

This textbook provides a state-of-the-art reference in the rapidly changing field of hernia surgery. With contributions by key opinion leaders in the field, this book describes the latest trends and detailed technical modifications for both routine and complex hernias. The reader will gain unique insights into robotic and laparoscopic repairs, anterior and posterior component separations, reconstructions in the setting of contamination, enterocutaneous fistulas and loss of abdominal domain. Important contributions from key reconstructive plastic surgeons detail modern trends on how to deal with complex skin and soft tissue challenges. The textbook provides unparalleled step-by-step instructions to perform both routine and complex repairs by incredible illustrations, intra-operative color photographs and a unique video collection of procedures performed by today's top hernia surgeons. As a comprehensive and most up-to-date reference to modern treatment algorithms, trends in prosthetic science and technique selections, Hernia Surgery: Current Principles will be an invaluable resource to all residents and practicing general, plastic, and trauma surgeons to help them succeed in the field of Hernia surgery.

A hernia is defined as a protusion or projection of an organ or a part of an organ through the body wall that normally contains it. The risk for inguinal hernia is highest among Caucasian males. Other risk factors include a history of another hernia, advanced age, abdominal wall injury, history of abdominal aortic aneurysm and smoking. Inguinal hernias have a variety of clinical presentations ranging from a finding of a painless bulge in the groin region on routine physical examination to emergent, life-threatening presentations due to bowel strangulation. Most hernias can be diagnosed on physical examination as a bulge in the groin while coughing or straining. The definitive treatment of all hernias, regardless of their origin or type, is surgical repair. The authors of this book examine the risk factors, prognosis and management options for inguinal hernia.

Trauma is the leading cause of death among people under the age of 40 and it ranks third for all age groups. Still, relatively few clinicians specialize in trauma and training is often obtained through experience. The number of trauma patients is expected to continue to grow as pre-hospital care continues to advance. As well, hospitals increasingly see trauma treatment, which requires no pre-approval, as a good source of revenue. Given these developments, the number of opportunities for specialists trained in trauma, including anesthesiologists and critical care physicians, will expand in the years ahead. This book addresses the need for an up-to-date, comprehensive and clinically focused volume for practitioners and trainees in trauma anesthesia and critical care. It is organized by organ system. The editor is an attending physician at a major urban hospital center recognized worldwide for its outstanding emergency medical services including trauma care and is recruiting leading trauma anesthesiologists to contribute. Anesthesiologists, pain medicine physicians, critical care physicians and trainees are the target audience.