1. Hospital Acquired Infections, Multidrug Resistant (MDR) Bacteria, Alternative Approaches to Antibiotic Therapy.
- Author
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Bostik, Pavel, Bostik, Pavel, and Kolar, Milan
- Subjects
Epidemiology & medical statistics ,Medicine ,23S rRNA ,AMR ,C. difficile ,ESBL ,ESBL-producing Klebsiella pneumoniae ,Enterococcus faecalis ,Enterococcus faecium ,Escherichia coli ,Escherichia spp ,GIT ,Klebsiella ,Klebsiella spp ,MDR ,MLST ,MRSA ,N-acetylcysteine ,PCR ,SCCmec typing ,Staphylococcus aureus ,UTIs ,VRE ,antibiotic resistance ,antibiotic stewardship ,antibiotic therapy ,antimicrobial resistance ,antimicrobial stewardship ,bacteria ,cancer patients ,carbapenem-resistant Acinetobacter baumannii ,carbapenem-resistant Klebsiella pneumoniae ,clinical impact ,clonal analysis ,clonal spread ,clonality ,cluster analysis ,colistin ,consumption of antibiotics ,critically ill patients ,duration of treatment ,economic impact ,endogenous infection ,enterobacterial repetitive intergenic consensus-polymerase chain reaction (ERIC-PCR) ,epidemiology ,hemato-oncological patients ,hops ,hospital ,infection ,infection prevention and control ,linezolid resistance ,long term care facilities (LTCF) ,methicillin-resistant ,methicillin-resistant Staphylococcus aureus (MRSA) ,multidrug resistance (MDR) ,multidrug-resistant Acinetobacter baumannii ,newborn ,optrA ,porcine model ,primer ,principal component analysis ,propensity score analysis ,pulsed-field gel electrophoresis (PFGE) ,rat model ,resistance ,septic shock ,spa typing ,urinary tract infection ,urinary tract infections ,uropathogens ,ventilator-associated pneumonia - Abstract
Summary: Bacterial resistance to known and currently used antibiotics represents a growing issue worldwide. It poses a major problem in the treatment of infectious diseases in general and hospital-acquired infections in particular. This is in part due to the overuse and misuse of antibiotics in past decades, which led to the selection of highly resistant bacteria and even so-called superbugs - multidrug-resistant (MDR) bacteria. Nosocomial infections, particularly, are often caused by MDR bacterial pathogens and the treatment of such infections is very complicated and extensive, often leading to various side effects, including adverse effects on the natural human microbiome. At the same time, the development of novel antibiotics is lagging with very few new ones in the pipeline. Finding viable alternatives to treat such infections may help to overcome these therapeutic issues. This publication brings novel developments in the field of bacterial resistance, mainly in the hospital settings, adequate antibiotic therapy, and identification of compounds useful to battle this growing issue.