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Encyclopedia of Food Allergy, organized in 10 sections, with ~200 chapters, and written by world-renowned clinician-scientist authors, is the most comprehensive resource for food allergy ever compiled. With online and physical presence, intuitive and easily accessible organization of information, the reader can quickly access overview and general topics as well as detailed information to inform solutions to clinical or research questions. Research topics provide the necessary background for the novice as well as the details required for those in the field. Clinical topics provide comprehensive and practical information, with generous use of tables, figures, and key points/clinical pearls, to inform clinical decision-making, and promote evidence-based management decisions. Food allergy may affect up to 10% of the population in developed countries and appears to be increasing in prevalence worldwide, with many food allergies proving life-long, severe and potentially fatal. The last decade has witnessed a sea change response to the impact of food allergy through basic science research on the immunology, food science research on the triggers, clinical approaches to daily management, treatment and prevention, and an increasing understanding of the psychosocial and societal implications and how to address them. With the expanding breadth and depth of the field, there is no existing comprehensive resource available for those professionals interested in learning about or contributing to food allergy research and clinical care. This is a complete resource covering broad and detailed aspects of food allergy and adverse food reactions for clinicians, researchers, regulators, food industry, students and other stakeholders who need and will benefit from a rich resource with in-depth and practical information. - Presents in-depth, comprehensive coverage from an outstanding international author base of domain experts - Ideal for new researchers and clinicians who will have a single resource that includes general topics to get them started - Includes access to detailed information in their areas of work AND for many related topics that will help improve their research or clinical care

A tool for students, educators, and clinicians, Foundations of Orthopedic Physical Therapy contains the latest literature in orthopedic physical therapy and guides readers through all elements of orthopedic assessment and treatment.Drs. Harvey Wallmann and Robert Donatelli offer a contemporary, evidence-based approach, working to address the topics that influence clinical decisions when developing rehabilitation and exercise programs. The text is consistent with the concepts and terminology presented in the APTA Guide to Physical Therapist Practice 3.0 and reviews the clinical practice guidelines for different conditions and body regions with an explanation of different levels of evidence.Foundations of Orthopedic Physical Therapy emphasizes a comprehensive method to assessment that produces treatment guidelines instead of rigid protocols and incorporates basic principles of evaluation, examination, and clinical reasoning. Each chapter contains author comments focusing on their perception of an effective patient intervention, evidence-based support for their decisions, and illustrative client case studies featuring unique and diverse patients who require specific interventions related to their orthopedic issues.Five main areas are addressed: Foundations of orthopedic rehabilitation Upper extremity Lower extremity Spinal column Special topics in orthopedic rehabilitation Foundations of Orthopedic Physical Therapy is the perfect guide for students intending to work with the orthopedic population in the treatment and intervention of injuries, pathologies, and disorders, or practicing physical therapists who want to expand their knowledge.

Ulcerative Colitis: The Complete Guide to Medical Management serves as the definitive source for medical management of ulcerative colitis (UC).Dr. Gary R. Lichtenstein, along with Dr. Ellen J. Scherl, have collaborated with over 60 experts from around the world to provide gastroenterologists and those in training with the necessary information to successfully manage the patient with ulcerative colitis. Sections Include:• Generalo The role of the FDA in drug development; pediatric considerations; disease modifiers; and more• Medicationso Antibiotic use in treatment of UC; oral novel biological therapies for UC; calcineurin inhibitors use in UC; novel biologic and non-biologic therapy for UC; and more• Specific Clinical Presentationso Medical management of toxic megacolon; management of extraintestinal manifestations; medical therapy of left-sided UC; use of prebiotics and probiotics; maintenance of remission; and moreFeatures:• Color images, graphs, and tables• Extensive index that includes cross-referencing to Crohn's Disease: The Complete Guide to Medical Management• Comprehensive references at the end of each chapterOrganized into an easy-to-reference format, Ulcerative Colitis: The Complete Guide to Medical Management threads theory into practice and provides gastroenterology professionals with the most comprehensive information available. The other side of inflammatory bowel disease is covered in Drs. Gary R. Lichtenstein and Ellen J. Scherl's Crohn's Disease: The Complete Guide to Medical Management. All gastroenterologists will find both books to be essential for future practice in the treatment and care of their patients with either Crohn's disease or ulcerative colitis, as well as in the overall management of those with inflammatory bowel disease.

The gold standard in gastrointestinal pathology textbooks returns More than 34 million Americans suffer from pathologies of the digestive system, with over 20 million of these disorders chronic. Treatment of these patients is a complex multidisciplinary area of clinical medicine, drawing upon expertise not only from specialist gastroenterologists but also pathologists, immunologists, endoscopists, and more. Morson & Dawson's Gastrointestinal Pathology has long set the standard for pathology textbooks, with its distinctive balance of clinical gastroenterology and pathology. Now fully updated to reflect the latest research in this vital field of medicine, it promises to bring this subject to a new generation of clinicians and pathologists worldwide. Readers of the sixth edition of Morson and Dawson's Gastrointestinal Pathology will also find: Contemporary recommendations and guidelines for getting the most out of every pathology specimen and producing the best possible report for managing the patientDiscussions of the evolving applications of immunohistochemistry and in situ hybridisationA completely new chapter on lymphoid and other tumours of the large intestine Morson & Dawson's Gastrointestinal Pathology is ideal for gastrointestinal pathologists, general pathologists, gastroenterologists, and any clinicians who work with or in gastrointestinal practice.

Crohn's Disease: The Complete Guide to Medical Management serves as the definitive source for medical management of Crohn's Disease (CD).Dr. Gary R. Lichtenstein, along with Dr. Ellen J. Scherl, have collaborated with over 60 experts from around the world to provide gastroenterologists and those in training with the necessary information to successfully manage the patient with Crohn's disease.Sections Include: General The role of the FDA in drug development; pediatric considerations; disease modifiers; and more Medications Antibiotic use in treatment of CD; oral budesonide; infliximab; novel biological and non biologic therapies for CD; and more Specific Clinical Scenarios Management of steroid unresponsive CD; management of enteric fistulae; use of pre- and probiotics; medical management of short bowel syndrome; maintenance therapy of CD; and more Features: Color images, graphs, and tables Extensive index that includes cross-referencing to Ulcerative Colitis: The Complete Guide to Medical Management An appendix on Infliximab treatment Comprehensive references at the end of each chapter Organized into an easy-to-reference format, Crohn's Disease: The Complete Guide to Medical Management threads theory into practice and provides Gastroenterology professionals with the most comprehensive information available on this disease state.The other side of inflammatory bowel disease is covered in Drs. Gary R. Lichtenstein and Ellen J. Scherl's Ulcerative Colitis: The Complete Guide to Medical Management. All gastroenterologists will find both books to be essential for future practice in the treatment and care of their patients with either Crohn's disease or ulcerative colitis, as well as in the overall management of those with inflammatory bowel disease.

Gott hat sich in Jesus Christus geoffenbart! Das bekennt und verkündigt der christliche Glaube seit 2000 Jahren. Was sagt er damit? Jesus von Nazareth hat in Galiläa und Jerusalem nicht lange gewirkt, vielleicht nur ein Jahr. Er hat Menschen geheilt, gelehrt, aber auch Entsetzen, Ängste und Hass ausgelöst. Einzelne sahen: Hier ist mehr als ein großer Lehrer und Prophet. Seit seiner Kreuzigung und seinen Auferstehungserscheinungen bezeugen Menschen: Jesus Christus lebt - er lebt in neuer Gestalt. Der auferstandene und erhöhte Christus wirkt in der Kraft seines Geistes. Er ist Gott von Gott, er besitzt schöpferische Macht. Große Teile der Menschheit lassen sich für das Reich Christi gewinnen. Viele Menschen allerdings missbrauchen seinen Namen für selbstherrliche Ziele, sogar für ihre Macht- und Eroberungsinteressen. Doch beharrlich wirkt er durch sein Wort, seinen Geist. Beharrlich ist sein Reich im Kommen: in Liebe und Barmherzigkeit, in der Suche nach Wahrheit und Gerechtigkeit, in Kräften der Erhebung und Erlösung. Die Kräfte dieses Reiches wecken in Menschen die Leidenschaft, ihre Gotteserkenntnis zu vertiefen und Gerechtigkeit zu suchen. Sie wirken emergent in vielen Taten der Liebe und Vergebung. Sie strahlen auch öffentlich aus, oft säkularisiert und politisch unter Menschen, die Bildung und Gesundheitsvorsorge für alle erstreben, freiheitliche Gemeinden und Zivilgesellschaften gestalten wollen und nicht aufhören, die unbedingte Achtung der Menschenrechte und der Menschenwürde einzuklagen. Die Ausstrahlungskräfte dieses Reiches verheißen und prägen erfülltes Leben - im Kleinen und im Großen, zeitlich und ewig. Michael Welkers Christologie, jetzt in vierter Auflage, erschließt diese Zusammenhänge. Damit antwortet sie auf die Frage, was der christliche Glaube sagt, wenn er bezeugt: In Jesus Christus offenbart sich Gott selbst.

This volume explores in detail the molecular biology, genetics and immunology of the bacterium Helicobacter pylori that causes serious gastric diseases such as gastric cancer. The book provides in-depth insights into the mechanisms of H. pylori-induced pathogenicity, gives an overview of how the bacterium colonizes the human gut, how it manages to persist in the body and which factors play a role in the development of H. pylori-induced gastric cancer. Furthermore, the interaction between the Gram-negative bacterium and the human gut microbiome is explored, and clinical management and treatment strategies to combat gastric cancer are discussed.Helicobacter pylori is an extremely successful pathogen that persistently colonizes the gut of about 50% of the world's population. H. pylori and its human host share a long co-evolutionary relationship that dates back for at least last 100,000 years and possibly longer. Infection by thisbacterium is a high-risk factor for the development of gastric diseases, including gastric cancer. Gastric cancer is associated with high morbidity and mortality and represents the 5th most common malignant tumour and the 4th leading cause of cancer-related death worldwide. H. pylori is the first bacterium that has been classified as a type-I carcinogen by the International Agency for Research on Cancer (IARC). Recent research progress identified crucial bacterial, host and environmental factors which control H. pylori-induced gastric malignancy. New studies also suggest that specific human germline mutations and other genetic aberrations have an important impact on H. pylori-induced pathology. In this volume, all these recently discovered mechanisms are reviewed in the light of gastric cancer development, and H. pylori epidemiology, virulence factors, immune evasion, pathophysiology, cancer signalling and novel therapeutic protocols are presented. This volume is aimed at researchers in the fields of immunology, genetics, microbiology and medicine who are interested in the detailed mechanisms of the pathogenicity of this carcinogenic stomach bacterium.

Steroid Biochemistry, Volume 688 in the Methods of Enzymology series, highlights new advances in the field, containing chapters on a variety of timely topics, including Cytochrome P450 Enzyme, Steroidogenic P450s (CYP11A1, 17A1, 21A2, 11B1, and 11B5), Steroid 17 alpha-hydroxylase/17,20-lyase (Cytochrome P450 17A1), Enzymes of Estrogen Biosynthesis, Aromatase and Steroid Sulfatase, Estrogenic 17b-Hydroxysteroid Dehydrogenase, Hydroxysteroid Dehydrogenases (HSD), 3a-Hydroxyssteroid Dehydrogenase, Approaches to Measuring 3b-Hydroxysteroid Dehydrogenase Type 1, 3b-Hydroxysteroid Dehydrogenase Type 2, and much more. - Provides the authority and expertise of leading contributors from an international board of authors - Presents the latest release in Methods in Enzymology serials - Updated release includes the latest information on Steroid Biochemistry

Anti-angiogenic Drugs as Chemosensitizers in Cancer Therapy, Volume 19 focuses on the use of anti-angiogenic drugs as sensitizers of tumor cells to the inhibitory activity of antitumor agents. Conventional and novel anti-neoplastic agents (cytotoxic molecules, hormones/antihormones, immunotherapies) are taken into consideration, along with advances made in combination therapies. The book encompasses examples of studies on the use of antiangiogenic compounds—molecules that inhibit the growth of vessels inside a tumor—together with antineoplastic drugs in order to sensitize the resistant tumor to their cytotoxic effects, thus reducing adverse side reactions and resistance and improving the therapeutic response of cancer patients. In addition, the book discusses clinical applications in various types of cancer, such as colorectal, lung, breast, renal, genitourinary, skin and brain and circulating tumors. It is a valuable resource for cancer researchers, clinicians and members of the biomedical field who wants to be up-to-date on the most recent and promising developments in the field. - Provides the most updated reviews on anti-angiogenic drugs as chemosensitizers by leaders in the field - Encompasses summarized tables and schematic diagrams in each chapter to give a clear overview on recent findings in a didactic manner - Brings not only relevant information of current research but also new ideas and suggestions for further investigations to help advance the field

The book covers all aspects of endoscopic biopsies of the stomach inclusive of gastritis and gastropathies. It highlights the best way of handling of endoscopic biopsies in the endoscopic room by the gastroenterologist. It elucidates various steps involved in processing of the biopsy, tissue embedding and paraffin sectioning, approach to interpretation, various precautions that require to be taken while interpreting the biopsies, and the essential background knowledge of the interpreter. The book highlights the importance of the little things for a proper reading like matching of the tissue fragments received and the number of tissue present on a slide after the paraffin section.Chapters cover various forms of gastritis, and the easiest approach for daily routine by avoiding the cumbersome classifications and staging formulated for gastritis. It also discusses the utilization of the right nomenclature for acute and chronic gastritis and various other subtypes of gastritis. Chapters include various rarer and infrequently come across conditions of both acute and chronic gastritis, special form of gastritis and infective conditions. It also includes unusual forms of non-neoplastic gastric pathologies such as, a condition, where the gastric mucosa is affected not only by direct exposure to various irritants but may also be affected by many systemic diseases. It also highlights the frequently observed changes in chronic renal and liver failures. The book is targeted to all the practicing pathologists as well as graduate and post graduate students who are keen to learn about non-neoplastic gastric pathology at various levels.

Der 89. Jahrgang des Lutherjahrbuches bietet verschiedene Beiträge, welche zentrale Aspekte von Luthers Theologie historisch und gegenwartsorientiert beleuchten, einflussreiche Akteure im Umfeld Luthers akzentuieren und bisher kaum bekannte Luthergedenkfeiern erinnerungskulturell pointieren. So wird beispielsweise der Thematik'Reinheit und Vergänglichkeit'bei Luther nachgespürt und Martin Chemnitz anlässlich seines 500. Geburtstags gedacht. Neue Erkenntnisse zur evangelischen Stundenliturgie im lutherischen Lübeck werden ebenso präsentiert, wie ein'moderner Luther'projektiert und die Eisenacher Jubiläumsfeierlichkeiten 1921 analysiert. Zum Teil erstmals abgedrucktes Quellenmaterial wie z.B. die Eisenacher Luther-Notgeldscheine bereichern die Aufsätze. Ausgewählte Buchbesprechungen und die für Lehre und Forschung unverzichtbare Lutherbibliographie orientieren darüber hinaus über bedeutende Publikationen zur Luther- und Reformationsforschung.

This work provides researchers with a thorough overview of all aspects related to the development of gluten-free food products. In summarizing and offering critical reviews of published works and focusing on current advances and technologies in gluten free product development, this book covers all of the important subjects related to this increasingly important aspect of the food industry. Important case studies in gluten-free breadmaking and alternative proteins are presented, making this a rich and singular source for food manufacturers and scientists seeking practical knowledge on the challenges and solutions involved in the development of gluten-free foods. Challenges and Potential Solutions in Gluten Free Product Development covers the latest advances and strategies for gluten-free diets including the important nutritional factors involved. Traditional and alternative approaches for the development of gluten-free dough, including starch applicationsand microbial fermentations, are extensively covered. Alternative proteins including those from vegetables, cereals, legumes and eggs are presented. Novel approaches for gluten-free breadmaking such as aeration strategies, prebiotics, hydrocolloids and nutritional enhancements are also covered in depth. With further chapters dedicated to regulatory aspects, gluten detection methods and the global market, this book presents full and up-to-date coverage of the development and manufacture of gluten-free products.

Dancing on the Sun Stone is a uniquely transdisciplinary work that fuses modern Latin American history and literature to explore women's lives and gendered politics in Mexico. In this important work, scholar Marjorie Becker focuses on the complex Mexican women of rural Michoacán who performed an illicit revolutionary dance and places it in dialogue with Nobel Prize winner Octavio Paz's signature poem, “Sun Stone”—allowing a new gendered history to emerge.Through this dialogue, the women reveal intimate and intellectual complexities of Mexican women's gendered voices, their histories, and their intimate and public lives. The work further demonstrates the ways these women, in dialogue with Paz, transformed history itself. Becker's multigenre work reconstructs Mexican history through the temporal experiences of crucial Michoacán females, experiences that culminate in their complex revolutionary dance, which itself emerges as a transformative revolutionary language.

Sex/gender - specific medicine (SGM) is defined as the practice of medicine based on the understanding that biology and social roles are important in men and women for disease prevention, screening, diagnosis, and treatment. Current research demonstrates differences in disease incidence, symptomatology, morbidity, and mortality based on sex and gender. Sex/gender-specific medicine is a fundamental aspect of tailored therapy and precision medicine. Therefore, the variables must be considered in medical education and practice as well as in research models ranging from human participants, animals and cells. Gastroenterology is very big and important division of Internal Medicine, which include esophagus, stomach, small and large intestine, pancreatobiliary tract and liver. Nowadays estrogen is known to play a key role in the prevention of colon cancer and progression of liver cirrhosis and hepatocellular carcinoma, especially in women. This book covers the sex/gender-specific medicine inthe area of gastrointestinal (GI) tract in the adults as well as in the pediatrics and in the gut microbiota.

Comprehensive and practical, Mills and Sternberg's Diagnostic Surgical Pathology, 7th Edition, presents advanced diagnostic techniques for differential diagnosis of the surgical specimen and the latest information on all currently known diseases. Led by Drs. Teri A. Longacre, Joel K. Greenson, Jason, L. Hornick, and Victor E. Reuter, a virtual “who's who” of experts in the field provide authoritative guidance on the diagnostic evaluation of every type of specimen from every anatomic site. Visually stunning and thoroughly up to date, this classic two-volume reference is a must-have resource no matter what your level of training or expertise.

A comprehensive guide, Women's Health in IBD: The Spectrum of Care From Birth to Adulthood will help providers approach the specific issues that women with inflammatory bowel disease (IBD) face throughout their lifetimes. This book will better equip providers to counsel and support women of all ages with IBD.In Women's Health in IBD, Drs. Bincy P. Abraham, Sunanda V. Kane, and Kerri L. Glassner focus on the unique aspects of care for women with IBD. Half of the IBD patient population is female. As we understand more about gender and sex differences in terms of genetics, physiology, and medical care, it is important to consider these factors between men and women to personalize their care.This book encompasses the entire life span of the female IBD patient through birth, adolescence, pregnancy, menopause, and older adult years. Each chapter includes discussions of medications, treatment plans, and common questions or controversies on important topics in IBD such as: Transitioning from pediatric to adult care Diet and nutrition Mental health Health maintenance Family planning Pregnancy and breastfeeding Menopause Concomitant irritable bowel syndrome Women's Health in IBD: The Spectrum of Care From Birth to Adulthood is an essential text that will help anyone who treats women with IBD, offering practical tools and takeaways for point of care and beyond.

This is the third volume in the Physics of Cancer (Second Edition) set. The book introduces and discusses novel and advanced applications for probing and sensing mechanical properties of cells and their microenvironment. In addition, biophysical techniques for analysing combined biophysical techniques and cellular functions are presented and discussed. However, the major scope of the book is the presentation of biophysical approaches in cancer and its major findings that contribute significantly to the field of physics of cancer from a biophysical point of view. Each chapter is a closed unit and at its end references allow the reader to step more deeply into each topic. When possible, videos will be provided as a special feature to enhance the topics.Key FeaturesWritten by a highly respected researcher in emerging fields within mechanics and electrics based experimental techniques in biophysics.Provides an authoritative coverage of cutting edge topics such as atomic force microscopy, cell-cell adhesion and traction force microscopy.Third volume of the Second Edition of the highly respected Physics of Cancer series.Features a sound introduction to cell and matrix mechanics and experimental techniques.

Enhanced recovery after surgery (ERAS) programs are a multidisciplinary approach in the perioperative care of the patient undergoing major surgery, including pre, intra and postoperative measures, based on the actual evidence published in literature (evidence-based medicine), to improve the postoperative recovery of the patient. ERAS protocols have been widely developed in colorectal surgery, but, given their excellent results, new protocols and guidelines have been developed in other surgical fields, including abdominal and extra-abdominal areas. In the last decade, several ERAS protocols have been implemented worldwide in bariatric surgery, confirming their safety and advantages of ERAS approaches, even on morbidly obese patients. The aim of this book is to update the actual evidence about ERAS protocols on bariatric surgery, analyzing separately the different components and multidisciplinary approach of the ERAS programs.

Novel Approaches to Colorectal Cancer, Volume 151 in the Advances in Cancer Research series, is composed of 11 reviews covering state-of-the-art research relating to the etiology, diagnosis, prevention and treatment of colorectal cancer. The book's chapters were written by recognized experts in the field, and include sections on molecular biomarkers in diagnosis and therapy, the interplay of diet, lifestyle, and the microbiome, early-age onset disease, mutational signature analysis, challenges in early detection, immunotherapy, organoid technology, the role of epigenetic alterations, disparities in minority populations, field carcinogenesis, and cancer as an evolutionary process. Each of these topics provides novel insights and concepts on various aspects of the nature of colorectal cancer, offering new opportunities for the management of a major source of cancer incidence and mortality. - Provides information on the timely nature of the included topics, which represent the most current concepts and approaches in cancer research - Offers outstanding and original reviews on colorectal cancer research - Provides the authority and expertise of the authors, all of whom are highly recognized and conducting state-of-the-art investigations in cancer, with this release focusing on colorectal cancer

This book offers a state-of-the-art, evidence-based reference to all aspects of veterinary cytology. Truly multidisciplinary in its approach, chapters are written by experts in fields ranging from clinical pathology to internal medicine, surgery, ophthalmology, and dermatology, drawing the various specialties together to create a comprehensive picture of cytology's role in diagnosis and treatment of animal disease. Firmly grounded in the primary literature, the book focuses on companion animals, with special chapters for species with fewer publications. Chapters are logically organized by body system, with additional chapters on tumors of particular import and diagnostic decision making. The first two sections of Veterinary Cytology focus on cytology techniques, quality control, and special laboratory techniques. Subsequent sections are organ/tissue-based and reflect what is known about the canine, feline, and equine species. This is followed by chapters on non-traditional species, including exotic companion mammals, rabbits, cattle, camelids, non-human primates, reptiles and birds, amphibians, fish, invertebrates, and sheep and goats. The last section highlights some unique features of the applications of cytology in industry settings. Provides a gold-standard reference to data-driven information about cytologic analysis in companion animal species Brings together authors from a wide range of specialties to present a thorough survey of cytology's use in veterinary medicine Offers broader species coverage and greater depth than any cytology reference currently available Veterinary Cytology is an essential resource for clinical and anatomic pathologists and any specialist in areas using cytology, including veterinary oncologists, criticalists, surgeons, ophthalmologists, dermatologists, and internists.

Volume 17- Television Technology to Wire Antennas. The only continuing source that helps users analyze, plan, design, evaluate, and manage integrated telecommunications networks, systems, and services, The Froehlich/Kent Encyclopedia of Telecommunications presents both basic and technologically advanced knowledge in the field. An ideal reference source for both newcomers as well as seasoned specialists, the Encyclopedia covers seven key areas--Terminals and Interfaces; Transmission; Switching, Routing, and Flow Control; Networks and Network Control; Communications Software and Protocols; Network and system Management; and Components and Processes.

Ruslan Mitkov's highly successful Oxford Handbook of Computational Linguistics has been substantially revised and expanded in this second edition. Alongside updated accounts of the topics covered in the first edition, it includes 17 new chapters on subjects such as semantic role-labelling, text-to-speech synthesis, translation technology, opinion mining and sentiment analysis, and the application of Natural Language Processing in educational and biomedical contexts, among many others. The volume is divided into four parts that examine, respectively: the linguistic fundamentals of computational linguistics; the methods and resources used, such as statistical modelling, machine learning, and corpus annotation; key language processing tasks including text segmentation, anaphora resolution, and speech recognition; and the major applications of Natural Language Processing, from machine translation to author profiling. The book will be an essential reference for researchers and students in computational linguistics and Natural Language Processing, as well as those working in related industries.

Das Lutherjahrbuch ist das bedeutendste Organ der internationalen Lutherforschung und wird im Auftrag der Luther-Gesellschaft e.V. von Christopher Spehr, Jena, herausgegeben. Ausgewählte Buchbesprechungen und die für Lehre und Forschung unverzichtbar Lutherbibliographie orientieren darüber hinaus über bedeutende Publikationen zur Luther- und Reformationsforschung.

This volume assembles and integrates the wealth of diverse information that is now accumulating in this burgeoning field. The existing and potential therapeutic applications of targeting CA cover a remarkably wide-range of diseases and disorders and have generated increasing and extensive interest in recent years. Its inter-disciplinary approach embraces both the most up-to-date therapeutic application of CA-targeting and the latest research data that will provide a platform for the development of novel applications. The interested audience comprises scientists and clinicians from many relevant disciplines within science and medicine.

With more consumers moving away from traditional cereal-based foods due to concerns about health impacts, including wheat intolerance, the sector must develop next generation nutritionally-enhanced cereal products to maximise market potential. Improving the nutritional and nutraceutical properties of wheat and other cereals provides a comprehensive coverage of the research into nutritional components of cereals, their interactions with the gut and the way processing can inhibit or optimise benefits. Despite the collection's strong focus on wheat and its nutritional properties, other cereal products, including oats, rye, spelt, sorghum and millet are discussed in terms of their own nutritional value. Edited by Professor Trust Beta, University of Manitoba, Canada, Improving the nutritional and nutraceutical properties of wheat and other cereals will be an excellent reference framework for academic researchers in cereal science, arable farmers, manufacturers/suppliers of cereal nutrition products, as well as government and private sector agencies supporting cereal production.

This book addresses one of the major challenges of immunology today that is being directed to the translation of the rapidly emerging volume of basic science contributions of immunology to clinical medicine. In so doing, the book systemically introduces and discusses concepts, classifications, phenotypic and functional descriptions of regulatory T (Treg) cells in health and disease. The authors of the 15 chapters were selected from among the most qualified experts in the field of Treg cell research who provide a comprehensive overview of Treg cells and their biology in the ensuing chapters.The beginning chapters provide a useful contemporary classification of Treg cell populations and then progress to chapters that explore basic mechanisms of Treg cell function and epigenetic control. In addition to descriptions of typical CD4+ Foxp3+ cells, other chapters provide detailed presentations of Treg subsets such as CD8+ Tregs and IL-10-producing Tr1 cells. The differences of various Treg subsets, as well as circulating and resident Treg cell populations, are next compared. Importantly, the next chapters provide the clinical correlation of Treg cells with autoimmune diseases, inflammatory diseases, metabolic diseases, cancer and organ transplantation and progress to chapters that highlight emerging innovative technology including nanoparticle-Treg cells and their translational values. In summary, the book will provide a valuable resource not only for graduate students and researchers in the fields of immunology, cell biology and translational medicine but also for all others interested in learning more about Treg cells and their application in human health and disease.

A Endoscopia Digestiva evolui a passos largos, graças às constantes evoluções tecnológicas e ao melhor conhecimento do comportamento biológico das principais afecções do aparelho digestivo. Assim, a Sociedade Brasileira de Endoscopia Digestiva (SOBED), que sempre se empenha na divulgação dos novos conhecimentos, promove constantemente a elaboração de material didático da especialidade. Esta Segunda Edição do Atlas de Endoscopia Digestiva da SOBED tem como importante diferencial a inclusão de vídeos sobre os diversos tópicos abordados, o que tornará mais fácil a compreensão, bem como mais dinâmica e agradável a leitura.

This book discusses unique ion channels and transporters that are located within epithelial tissues of various organs including the kidney, intestine, pancreas and respiratory tract. As the authors show, these channels and transporters play crucial roles in transepithelial ion and fluid transport across epithelia and their contribution to maintaining homeostasis. Readers will be introduced to the fundamentals of ion transport in terms of function, modelling, regulation, structure and pharmacology. This is the first of three volumes highlighting the importance of epithelial ion channels and transporters in basic physiology and pathophysiology of human diseases. This volume focuses on basic fundamentals of epithelial transport physiology. There is a range of chapters dedicated to specific aspects of epithelial ion transport and cell function. Accordingly, the authors discuss techniques used to determine epithelial function, principles of epithelia transport, polarization of epithelial cells, mathematical modelling of epithelial ion transport, protein folding of ion channels, degradation epithelial ion channels, fundamentals of epithelial sodium, potassium and chloride transport, fundamentals of bicarbonate secretion, volume regulation, and microRNA regulation of epithelial channels and transporters. Given its scope, Volume 1 offers a valuable resource for physiology students, scientists and clinicians alike.

pH Interfering Agents as Chemosensitizers In Cancer Therapy, Volume Thirteen, provides a detailed overview of the chemosensitizers for the treatment of cancer spanning from biochemical and structural features to pharmacology and drug-design, including technological applications. The book is structured with innovative outlines and a distinction between experimental and clinical results. The continuous discovery and assessment of the role played by old/new synthetic drugs, natural compounds and technological applications has led to the urgent need of classification in terms of biological activity, mechanism of action, clinical outcomes, cancer cell lines sensible to the treatment, and potentialities to better orient research in this field. Moreover, all the aspects relevant for medicinal chemistry (drug design, structure-activity relationships, permeability data, cytotoxicity, appropriate statistical procedures, and molecular modeling studies) are strictly considered. - Presents a broad view of the topic according to a medicinal chemistry-based approach beyond syntheses and biological assays, focusing on SAR studies, chemoinformatic, drug targeting and molecular modeling - Explains the mechanism of action of the chemosensitizers by means of schemes and figures to facilitate comprehension - Discusses novel targets to explore new possibilities that enhance research in the field

This book discusses the unique ion channels and transporters found within the epithelial tissues of various organs, including the kidney, intestine, pancreas and respiratory tract. Authors focus on demonstrating the crucial roles that each of these channels and transporters play in transepithelial ion and fluid transport across epithelia, as well as in maintaining homeostasis. It allows readers to gain an understanding of the fundamentals of ion transport, in terms of function, modelling, regulation, trafficking, structure and pharmacology. This is the second of three volumes highlighting the importance of epithelial ion channels and transporters in basic physiology and pathophysiology of human diseases. This volume focuses on a wide array of epithelial tissues and the use of organoids to study epithelial function. Furthermore, clinical researchers and basic scientists from various fields provide a medical perspective on the physiology of a number of tissues and organs of the body including the pancreas, intestine, sweat glands, mammary gland, inner ear epithelia, retinal pigment epithelia of the eye, choroid plexus, and the ectodermal epithelia in dental enamel formation. This volume aims to ‘round out'the reader's journey from basic science to the laboratory bench and clinical management of molecular diseases, making Volume 2 a must-read for students and scientists in the field of physiology, as well as for clinicians.

Handbook of Silicon Based MEMS Materials and Technologies, Third Edition is a comprehensive guide to MEMS materials, technologies, and manufacturing with a particular emphasis on silicon as the most important starting material used in MEMS. The book explains the fundamentals, properties (mechanical, electrostatic, optical, etc.), materials selection, preparation, modeling, manufacturing, processing, system integration, measurement, and materials characterization techniques of MEMS structures. The third edition of this book provides an important up-to-date overview of the current and emerging technologies in MEMS making it a key reference for MEMS professionals, engineers, and researchers alike, and at the same time an essential education material for undergraduate and graduate students. - Provides comprehensive overview of leading-edge MEMS manufacturing technologies through the supply chain from silicon ingot growth to device fabrication and integration with sensor/actuator controlling circuits - Explains the properties, manufacturing, processing, measuring and modeling methods of MEMS structures - Reviews the current and future options for hermetic encapsulation and introduces how to utilize wafer level packaging and 3D integration technologies for package cost reduction and performance improvements - Geared towards practical applications presenting several modern MEMS devices including inertial sensors, microphones, pressure sensors and micromirrors

The Autoimmune Diseases, Sixth Edition, emphasizes the'3 P's'of 21st Century medicine: precision, prediction and prevention. Topics cover the modern systems approach to biology that involves large amounts of personalized, ongoing physiologic data ('omics') coupled with advanced methods of analysis, new tests of genetic engineering, such as CRISPR, auto inflammatory diseases, autoimmune responses to tumor immunotherapy, and information on normal immune response and disorders. Each of the major autoimmune disorders is discussed by researchers and clinical investigators experienced in dealing with patients. Chapters emphasize the immunologic basis of the disease as well as the use of immunologic diagnostic methods and treatments. The book also covers several cross-cutting issues related to the recognition and treatment of autoimmune diseases, including chapters on the measurement of autoantibodies and T cells, the use of biomarkers as early predictors of disease, and new methods of treatment. - Gives a thorough and important overview on the entire field, framing individual disease chapters with information that compares and contrasts each disorder and its therapy - Provides thorough, up-to-date information on specific diseases, along with clinical applications in an easily found reference for clinicians and researchers interested in certain diseases - Keeps readers abreast of current trends and emerging areas in the field - Ensures that content is not only up-to-date, but applicable and relevant - Includes new, updated chapters that emphasize hot topics in the field, e.g., research on auto inflammatory diseases and autoimmune responses following cancer immunotherapy

Wheat and Barley Grain Biofortification addresses topics associated with the alleviation of malnutrition in globally diverse populations via wheat and barley biofortification. The book synthesizes the current trends of malnutrition across the globe, the need for wheat and barley nutritional enhancement and how agronomic, microbial and molecular understanding of biofortification can help in devising significant approaches and strategies. In addition, it includes discussions on potential genetic variability available and their efficient utilization in wheat and barley for molecular breeding for nutrients, challenges and opportunities for bioavailability, and technical advancement for analysis of bioavailability. - Addresses the need for wheat and barley biofortification to address global nutrition demands - Places emphasis on the current agronomic and molecular understanding of biofortification - Discusses the potential utilization of genetic variability - Highlights the economics of biofortification over fortification technology

For nearly 50 years, Sleisenger & Fordtran's Gastrointestinal and Liver Disease has been the go-to reference for gastroenterology and hepatology residents, fellows, physicians, and the entire GI caregiving team. Now in a fully revised 11th Edition, this two-volume masterwork brings together the knowledge and expertise of hundreds of global experts who keep you up to date with the newest techniques, technologies, and treatments for every clinical challenge you face in gastroenterology and hepatology. A logical organization, more than 1,100 full-color illustrations, and easy-to-use algorithms ensure that you'll quickly and easily find the information you need. - Features new and expanded discussions of chronic hepatitis B and C, Helicobacter pylori infection, colorectal cancer prevention through screening and surveillance, biologic agents and novel small molecules to treat and prevent recurrences of inflammatory bowel disease (IBD), gastrointestinal immune and autoimmune diseases, and more. - Offers reliable coverage of key topics such as Barrett's esophagus, gut microbiome, enteric microbiota and probiotics, fecal microbiota transplantation, and hepatic, pancreatic, and small bowel transplantation. - Provides more quick-reference algorithms that summarize clinical decision making and practical approaches to patient management. - Employs a consistent, templated, format throughout for quick retrieval of information. - Includes monthly updates online, as well as more than 20 procedural videos. - Expert Consult™ eBook version included with purchase. This enhanced eBook experience allows you to search all of the text, figures, and references from the book on a variety of devices.

This book covers the entire spectrum of non-neoplastic diseases within the gastrointestinal (GI) tract including new entities, recent developments, and questions that arise in the practice of GI pathology. The text is organized by specific organ site, with related disorders of each organ site subgrouped into several chapters based on their common features. Pathologists can quickly find the disorders they are interested and review similar disorders in the same chapter to help them make a correct diagnosis. Each major and common entity is described in detail with its definition, clinical features, pathological features (covering both the gross and microscopic details), differential diagnosis and treatment/prognosis. All chapters also highlight the use of special/immunohistochemical stains and other supporting studies as needed with a focus on providing a practical differential diagnosis rather than just a list of potential associations. This book is extensively illustrated with bothgross and microscopic images that act as an integral part of the information provided in the text. Written by practicing GI/liver pathologists and gastroenterologists from the Mayo Clinic, Surgical Pathology of Non-neoplastic Gastrointestinal Diseases serves as a comprehensive yet practical guide for diagnostic surgical pathologists with a passion for GI pathology.

First Published in 1988, Interstitial Lung Diseases in Children identifies, describes and offers insight into how to treat the vast array of lung diseases found in infants, children, and teenagers. Filled with clear and useful references, this book works best as a guide for Pediatricians and those with a keen interest in Medicine.

First Published in 1993, this book offers a full, comprehensive guide into Myasthenia Gravis and how it affects our muscular function. Carefully compiled and filled with a vast repertoire of notes, pictures, and references this book serves as a useful reference for Students of Medicine, and other practitioners in their respective fields.

Das Lutherjahrbuch ist das bedeutendste Organ der internationalen Lutherforschung und wird im Auftrag der Luther-Gesellschaft e.V. herausgegeben. Der 86. Jahrgang erinnert mit seinem diesjährigen Schwerpunkt an die Gründung der Gesellschaft vor 100 Jahren, indem er die Vorträge der Jubiläumstagung'1918 Auf-Bruch 2018'dokumentiert. Darüber hinaus werden von unbekannten Tischreden über Luthers'letzte Kutte', den Fabeldichtungen, Luthers Obrigkeitslehre und Theologieverständnis bis hin zur lutherischen Wirkungsgeschichte anhand von Zedlers Universallexikon substanzhafte interdisziplinäre Beiträge geboten, die ein Muss für jeden Lutherforscher sind. Ausgewählte Buchbesprechungen und die für Lehre und Forschung unverzichtbar Lutherbibliographie orientieren darüber hinaus über bedeutende Publikationen zur Luther- und Reformationsforschung.

Transplantation, Bioengineering, and Regeneration of the Endocrine Pancreas, Volume 2, sets a new standard in transplant and regenerative medicine. The book details the state-of-the-art in modern islet auto-transplantation, also discussing current progress in regenerative medicine research in diabetes medicine. Regenerative medicine is changing the premise of solid organ transplantation, hence this volume catalogs technologies being developed and methods being implemented. Bioengineering and regenerating beta cells, clinical pancreas and islet transplantation, tissue engineering, biomaterial sciences, stem cell biology and developmental biology are all addressed and applied directly to diabetes medicine. - Provides comprehensive and cutting-edge knowledge of whole pancreas and islet transplantation - Addresses imaging, treatment, scaffold technology, the use of stem cells to generate insulin, 3D printing, and more - Offers an update on the progress of regenerative medicine research aimed at beta cell replacement for the treatment of diabetes

This book gives a solution to the problem of constructing lightwave paths in free spaces by proposing the concept of a Self-Organized Lightwave Network (SOLNET). This concept enables us to form self-aligned coupling optical waveguides automatically. SOLNETs are fabricated by self-focusing of lightwaves in photosensitive media, in which the refractive index increases upon light beam exposure, to realize the following functions: 1) Optical solder: Self-aligned optical couplings between misaligned devices with different core sizes 2) Three-dimensional optical wiring 3) Targeting lightwaves onto specific objects SOLNETs are expected to reduce the efforts to implement lightwaves into electronic systems and allow us to create new architectures, thus reducing costs and energy dissipation and improving overall system performance. SOLNETs are also expected to be applied to a wide range of fields where lightwaves are utilized, for example, solar energy conversion systems and biomedical technologies, especially photo-assisted cancer therapies. Readers will systematically learn concepts and features of SOLNETs, SOLNET performance predicted by computer simulations, experimental demonstrations for the proof of concepts, and expected applications. They will also be prepared for future challenges of the applications. This book is intended to be read by scientists, engineers, and graduate students who study advanced optoelectronic systems such as optical interconnects within computers and optical networking systems, and those who produce new ideas or strategies on lightwave-related subjects.

The sixth edition of Walker's Pediatric Gastrointestinal Disease is dedicated to a comprehensive worldwide representation of advances in pediatric gastroenterology, its pathophysiology, diagnosis, and management. This standard reference text is enhanced by color images and tables throughout the two-volume set. Pediatricians, gastroenterologists, hepatologists, and medical students will appreciate sections on techniques used to establish diagnosis of complex pediatric conditions of the gut, pancreas, and liver. Walker's Pediatric Gastrointestinal Disease includes new chapters devoted to nutrition that complement the companion text Nutrition in Pediatrics (ISBN 9781607951803).

In this compilation, the authors open with a discussion on lectins, carbohydrate-binding proteins which are widely present in living organisms and participate in molecular recognition and intracellular functions. Due to their carbohydrate specificity, lectins can be employed as an analytical tool to study glycan structures on glycoconjugates. Plant lectins have also been used to study glycosylation pattern of animal glycoproteins. The first chapter includes a brief review on lectins, a summary of the general information on glycoconjugate, a review on lectin-affinity techniques and their potential, as well as perspectives of the employment of lectins in the estimation of the glycosylation pattern of glycoconjugates. Next, the authors discuss the cytokine interleukin-7 and its many diverse and important functions in the development and maintenance of immune cells. For haematopoiesis, depending on particular cell type, IL-7 is important for cell survival, proliferation and differentiation. The cytokine's receptor is expressed by early progenitors of B, T lymphocytes and Innate Lymphoid Cells, and IL-7 signaling is critical for the generation of these cells. The authors go on to examine enzyme therapy as a modern way of providing better protection for people with coeliac disease and sensitivity to gluten who have been placed solely on a lifelong gluten-free diet. By itself, the gluten-free diet is not always fully protective of the small intestine because small amounts of gluten can be present from contamination and the failure to recognize “hidden gluten” in food. This chapter explains how certain supplements are able to help those with gluten sensitivity overcome the harmful effects of gluten and reduce the worry about contamination of their food and the lack of knowledge about its gluten content. These supplements represent an important development of the gluten-free diet and will assist in patient management to ensure that patients remain free from the effects of gluten. Later, adrenergic urticarial, a well-defined-yet-neglected variant of urticarial, is discussed. It is characterized by a peculiar clinical picture, with small hives surrounded by white haloes due to local vasoconstriction. Lastly, the authors discuss how abnormalities in physical properties of the cell membranes may be strongly linked to cerebro- and cardiovascular diseases. Recent evidence indicates that increased plasma levels of tumor necrosis factor-a (TNF-a), an inflammatory cytokine, may actively participate in the pathophysiology of endothelial dysfunction, hypertension and other circulatory disorders. The present study was performed to investigate the possible relationships among plasma TNF-a, asymmetric dimethylarginine and membrane fluidity in hypertensive and normotensive subjects using an electron spin resonance (ESR)-spectrometry.

This volume provides reviews covering the latest advances in particular areas of connective tissue research. This comprehensive work also includes areas of the medical field in which the basic aspects could be applied. It explains that both cells and matrix are altered in disease states because of the strong interactions established between cells and the extracellular matrix. The aim of this book is to close the existing gap between basic scientists and clinical investigators. This reference is an absolute must for all biological chemists, clinical investigators, and pathologists. Students of these professions will find this reading both informative and useful as well.

Helicobacter pylori: Biology and Clinical Practice is the first book to fully describe H. pylori and the pathogenesis of H. pylori infections. It delineates the genome of H. pylori, discusses the molecular biology of the unique urease enzyme, and examines the clinical application of these discoveries. The book describes the epidemiology of H. pylori and its relevance to gastric cancer, and it offers clear guidance to clinicians for the diagnosis and treatment of peptic ulcer and non-ulcer dyspepsia in adults and children. Vaccine principles and possibilities are presented for the first time. Edited by the leader of the microbiology team that achieved the first culture of H. pylori, and named the Helicobacter genus, this book is essential for bacteriologists, gastroenterologists, microbiologists, infectious disease specialists, and other researchers interested in H. pylori.

Angesichts der globalen Vielgestaltigkeit von Religion stellt sich die Frage nach den Gründen für diese unterschiedlichen Ausformungen. Das Handbuch versammelt Beiträge, die Religion(en) in ihrer Vielfalt, ihren sozialen Konfigurationen und Wandlungsdynamiken kontextualisieren. Damit wird gezeigt, wie sich Religion in gesellschaftlicher, struktureller, institutioneller, praktischer und überzeugungsbezogener Perspektive ausformt. Als Kontexte werden Ordnungen wie diejenige des Geschlechts, des Alltags, der Ökonomie, Institutionen der Staatlichkeit und des Rechts oder auch Dynamiken wie sie durch Minderheitenrelationen, gesellschaftliche Transformationen und Modernisierungen verursacht werden, eingeführt. Die Beiträge zeigen anhand empirischer Beispiele Mechanismen, durch die Religionen jeweils gesellschaftsgeschichtlich geformt, sichtbar gemacht und verwirklicht werden. Der Band richtet sich an alle, die mehr darüber wissen wollen, wie Religion(en) in verschiedene Gesellschaften und deren Veränderungen eingebettet sind. Mit Beiträgen von Olayinka Akanle & Gbenga S. Adejare; Tilo Beckers; Heiko Beyer; Marc Breuer; Christel Gärtner; Felipe Gaytán Alcalá; Stephen Hunt; James Kapaló; Vladimir Kmec; Jens Köhrsen; Jere Kyyrö; Emily McKendry-Smith; Gert Pickel; Melanie Reddig; Kornelia Sammet & Franz Erhard; Elisabeth Scherer; Annette Schnabel; Rainer Schützeichel; Ulf Tranow; Bryan S. Turner; Heidemarie Winkel; Daniel Witte.

In this compilation, the authors address the relationship between carbonic anhydrase IX and hypoxia. Hypoxia is a key factor influencing a life-cycle of CA IX, including its expression, correct structure, stability, function, and subsequent biological implications. Hypoxia also regulates CA IX expression by post-transcriptional mechanisms through splicing and mRNA stabilization. A review is provided focusing on the sequence of elementary reactions ensuing a catalytic reaction (catalytic mechanism) of carbonic anhydrase. The closing chapter discusses carbonic anhydrases in chloroplasts, especially their location in the organelles, as well as considers their uses.

Applications of Mass Spectrometry Imaging to Cancer, the latest volume in the Advances in Cancer Research provides invaluable information on the exciting and fast-moving field of cancer research. This volume presents original reviews on applications of mass spectrometry imaging to cancer. - Provides information on cancer research - Offers outstanding and original reviews on a range of cancer research topics - Serves as an indispensable reference for researchers and students alike

This book reviews different aspects of the cancer microenvironment, and its regulation and importance for tumor progression. Practical applications, in terms of how biomarkers are increasingly included in therapy protocols, will also be discussed. Biomarkers of the Tumor Microenvironment: Basic Studies and Practical Applications is aimed at research pathologists in the cancer field, and also cancer researchers from other backgrounds, especially those using morphology techniques and models focusing on cross-talk between different cell types in tumors.

Comprehensive Toxicology, Third Edition, Fifteen Volume Set discusses chemical effects on biological systems, with a focus on understanding the mechanisms by which chemicals induce adverse health effects. Organized by organ system, this comprehensive reference work addresses the toxicological effects of chemicals on the immune system, the hematopoietic system, cardiovascular system, respiratory system, hepatic toxicology, renal toxicology, gastrointestinal toxicology, reproductive and endocrine toxicology, neuro and behavioral toxicology, developmental toxicology and carcinogenesis, also including critical sections that cover the general principles of toxicology, cellular and molecular toxicology, biotransformation and toxicology testing and evaluation. Each section is examined in state-of-the-art chapters written by domain experts, providing key information to support the investigations of researchers across the medical, veterinary, food, environment and chemical research industries, and national and international regulatory agencies. Thoroughly revised and expanded to 15 volumes that include the latest advances in research, and uniquely organized by organ system for ease of reference and diagnosis, this new edition is an essential reference for researchers of toxicology. - Organized to cover both the fundamental principles of toxicology and unique aspects of major organ systems - Thoroughly revised to include the latest advances in the toxicological effects of chemicals on the immune system - Features additional coverage throughout and a new volume on toxicology of the hematopoietic system - Presents in-depth, comprehensive coverage from an international author base of domain experts