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Sustainable Hard Machining: Implementation and Assessment analyzes the various methodologies of cooling and lubrication employed during hard machining operations, along with their potential contributions towards achieving sustainable machining. It includes the needs, challenges and trends towards sustainable hard machining of difficult-to-cut materials through the application of dry, minimum quantity lubrication (MQL), cryogenic and nanofluid assisted MQL for environmental, economic, ecological and societal benefits, leading to environmentally cleaner sustainable machining.Features: Provides an introduction to hard machining, sustainability and environmentally conscious machining Discusses dry and minimum quantity lubrication (MQL) based hard machining Includes computational methods and optimization in hard machining Reviews nano-cutting fluids in hard machining Explores cryogenic cooling in hard machining This book is aimed at graduate students and researchers in mechanical engineering, manufacturing and materials science.

Discover a comprehensive and up-to-date reference resource for bone marrow pathology, complete with an extensive list of references The diagnosis and treatment of bone marrow pathologies is one of the most critical areas of medical research and care. For years, Bone Marrow Pathology has served as the essential reference and teaching tool in the field of haematology, with an authoritative treatment of the subject written by acknowledged leaders in the field. Now fully updated to reflect urgent new changes to the theory and practice of haematology, it promises to serve a new generation of practitioners. In the book, the characteristics and function of normal bone marrow are extensively discussed. Bone marrow pathology, including both aspirate films and trephine biopsy sections, is examined in a clinical context. The content is augmented by discussion of the peripheral blood findings and supplementary bone marrow tests. Readers of the sixth edition of Bone Marrow Pathology will also find: Lavish illustrations with high-quality images of bone marrow and other associated imagesIncorporation of new classifications including the WHO and International Consensus classifications, as well as new and expanded research areasEmphasis on practical tools including differential diagnosis and common problems and pitfallsA practical, integrated approach to diagnosis Perfect for trainee and consultant haematologists and haematopathologists, Bone Marrow Pathology will also prove itself invaluable for cytogeneticists, molecular geneticists and anyone working in immunophenotyping.

Cytokine Storm Syndromes, including HLH and MAS, are frequently fatal disorders, particularly if not recognized early and treated during presentation. The genetics of Cytokine Storm Syndromes are being defined with many of the risk alleles giving rise to mutations in the perforin-mediated cytolytic pathway used by CD8 cytotoxic T cells and natural killer cells. These are being studied using murine models. Up to 10% of the general population may carry risk alleles for developing Cytokine Storm Syndromes, and Cytokine Storm Syndromes are being increasingly recognized around the world in pediatric and adult hospitals. A variety of infectious, rheumatic, and oncologic triggers are commonly associated with Cytokine Storm Syndromes, but understanding this disorder is critical for all researchers and physicians to ensure timely and appropriate therapy. This second edition addresses all aspects of the disorder, from genetics, pathophysiology, and ongoing research, to clinical presentations, risk factors and treatment. New-to-this-edition features include dedicated chapters on severe COVID-19 CSS, and post-COVID CSS of multi-system inflammatory syndrome in children (MIS-C). In addition, novel topics including CSS associated with Castleman disease, pregnancy, therapeutics, transplantation, and cardiac bypass, as well as treatment with JAK inhibitors are addressed.

This important collection provides an epidemiological perspective on the continuing scope of sickle cell disease (SCD) in sub-Saharan Africa, alongside the clinical attempts to provide comprehensive care in a resource-limited setting.The book moves from a clinical profile of SCD to screening for the disease and ongoing patient care. There are chapters on pain management, organ failure, infections and transfusions, as well as nutrition and neurocognitive complications. The book concludes with chapters on anti-sickness medication, cell transplantation and nursing care.The first in a two-volume set offering a multi-disciplinary perspective on SCD, this is a comprehensive resource that applies clinical knowledge to the practical challenges faced in sub-Saharan Africa. It will be important reading for medical students taking courses in haematology as well as those studying Public Health in sub-Saharan Africa. Practitioners in the region will also find it invaluable in developing their understanding of this pervasive disease.

Comprehensive Hematology and Stem Cell Research is the first major reference to cover both stem cell research and therapy as well as the range of hematological disorders they are currently used to treat and may potentially be able to treat in the future. This five volume set includes fundamentals, such as the underlying mechanisms of the blood and immune system, highlighting blood disorders and cancers of the blood, including lymphoma, leukemia, and myeloma. Other sections cover stem cell research and therapy, from harvesting stem cells to their utilization in cancer treatments. Finally, the work looks to the future and explores newer stem cell research that may lead to future treatments. This book is an excellent resource for students at the graduate and post-graduate levels, academics, and researchers in the fields hematology, immunology and oncology. - Compiles foundational knowledge and breakthrough research into one concise, comprehensive reference - Takes a translational, bench-to-bedside approach to hematological disorders and stem cell therapies - Covers clinical applications of stem cells, advances in the field, and promising new research

Hematology Timely morphology resource based on ongoing series of morphology updates published in the American Journal of Hematology since 2008 This is the first book of its kind, written by renowned author Professor Barbara J. Bain, featuring a collection of instructive cases with interesting morphological features initially published in the American Journal of Hematology. This new book aims to bring these interesting and instructive cases to a wider readership. This book features updated cases and a “Test Yourself” section to aid in reader comprehension and information retention. Cases covered in Hematology: 101 Morphology Updates include: The significance of irregularly contracted cells and hemighosts in sickle cell disease, and striking dyserythropoiesis in sickle cell anemia following an aplastic crisis Prominent Howell-Jolly bodies when megaloblastic anemia develops in a hyposplenic patient, and unusual aspects of G6PD deficiency The cause of sudden anemia revealed by the blood film, chorea-acanthocytosis and dysplastic neutrophils in an HIV-positive woman Neutrophil dysplasia induced by granulocyte colony-stimulating factor, and diagnosis of pyrimidine 5'-nucleotidase deficiency suspected from a blood film Hematology: 101 Morphology Updates is a key resource for consultant hematologists and clinical scientists, trainee hematologists and biomedical scientists. The audience may use this book to solve difficult diagnostic problems or as a source of teaching cases: for both personal learning, including exam revision or solving difficult cases, and as a teaching resource.

Selected peer-reviewed full text papers from the 3rd International Conference on Materials Science and Manufacturing Technology (ICMSMT 2021)Selected peer-reviewed full text papers from the 3rd International Conference on Materials Science and Manufacturing Technology (ICMSMT 2021), April 08-09, 2021, Tamil Nadu, India

This book is quick guide on the hematopoietic stem cell transplant (SCT), also called bone marrow transplant (BMT) - an evolving field of hematology and hemato-oncology. This book covers the various types of stem cell transplants like autologous and allogeneic stem cell transplants, indications, ways of doing a transplant, and stem cell transplants basic principles. Written in a question-answer format, readers will find it more interesting as one question sequentially leads to another. This book explains the complications of SCT in individual chapters along with the biology of T cells which are the most important cells involved in the success of SCT This book is beneficial to the budding hematologists, oncologists, and postgraduates interested in SCT and helps students in their exams. The book would be helpful for readers globally as SCT is a procedure done worldwide and is an ever-increasing field for treating various benign and malignant hematological diseases.

Nanocomposites (both heterogeneous and anisotropic) are hard to machine due to their enhanced properties and there is a need to know about the problems associated with the machining of nanocomposites by various conventional as well as non-conventional machining operations. Machining of nanocomposites emphasizes on different fabrication methods to develop nanocomposites (polymers, metals, and ceramics) and different machining processes used in industries. Further, it describes issues and challenges including research trends associated with the same. It also evaluates mechanical and wear properties of the composites as well.Features: Covers manufacturing process of nanocomposites. Includes conventional and non-conventional machining process and relevant applications. Addresses effect of different nano-reinforcements on machinability. Discusses usage of design of experiments and optimization technique to improve the machinability of nanocomposites. Reviews challenges on machining of nanocomposites and its remedies. This book aims at Researchers, Graduate students in Mechanical Engineering, and Materials Sciences including Composites, Nanotechnology, and Machining.

This book constitutes the thoroughly refereed post-workshop proceedings of the 6th International Workshop on Modelling and Simulation for Autonomous Systems, MESAS 2019, held in Palermo, Italy, in October 2019. The 22 full papers and 13 short papers included in the volume were carefully reviewed and selected from 53 submissions. They are organized in the following topical sections: M&S of intelligent systems - AI, R&D and application; future challenges of advanced M&S technology; AxS in context of future warfare and security environment (concepts, applications, training, interoperability, etc.).

This book presents the potential applications of hard materials as well as the latest trends and challenges in machining hard materials. Models for online monitoring to adjust parameters to obtain desired machining characteristics (i.e. reverse modelling) are discussed in this book. The conflicting requirements (i.e. maximize: material removal rate, roundness and minimize: surface roughness, dimensional ovality, co axiality, tool wear) in machining for industry personal is solved using advanced optimization tools. In addition, the framework for experimental modelling, predictive physic-based forward and reverse process models and optimization for better machining characteristics applicable to industry are proposed.

Thickening Fat: Fat Bodies, Intersectionality, and Social Justice seeks to explore the multiple, variable, and embodied experiences of fat oppression and fat activisms. Moving beyond an analysis of fat oppression as singular, this book will aim to unpack the volatility of fat—the mutability of fat embodiments as they correlate with other embodied subjectivities, and the threshold where fat begins to be reviled, celebrated, or amended. In addition, Thickening Fat explores the full range of intersectional and liminal analyses that push beyond the simple addition of two or more subjectivities, looking instead at the complex alchemy of layered and unstable markers of difference and privilege.Cognizant that the concept of intersectionality has been filled out in a plurality of ways, Thickening Fat poses critical questions around how to render analysis of fatness intersectional and to thicken up intersectionality, where intersectionality is attenuated to the shifting and composite and material dimensions to identity, rather than reduced to an “add difference and stir” approach. The chapters in this collection ask what happens when we operationalize intersectionality in fat scholarship and politics, and we position difference at the centre and start of inquiry.

Bone Marrow transplantation or Hematopoietic stem cell transplantation is a life saving procedure in a number of diseases,hematological and non hematological, which fail alternative medical management or have no other treatment options. It has transformed the lives of thousands of patients and their families around the world battling with fatal or debilitating diseases.There are many unique aspects of bone marrow transplantation which makes it very different from solid organ transplants. There is an enormous amount of research going on in this field both at clinical and basic science levels.With the rapidly changing world and field of transplantation, there is a need for an authoritative and up to date resource for transplant professionals.This book titled Contemporary Bone Marrow Transplantation aims to be a reference text comprehensively covering various facets of hematopoietic stem cell transplants with latest insights about the technique and basic sciencebehind it. The book is the product of collective effort of transplant professionals round the world, and will reflect their experience as well as the current standard of care practices in Stem cell transplantation.The book will be divided into different sections focusing on the basic science of bone marrow transplant, the technical aspects of the procedure itself and the supportive care of transplant patients.There will also be a section each on epidemiology, upcoming trends and also case studies, which will discuss real case scenarios from the experience of the authors, to illustrate the practical challenges in managing bone marrow transplant recipients.

There is an ever-increasing demand for more food but one of the stumbling blocks to achieving this goal is quality and quantity losses due to various pests and pathogens and the mycotoxins synthesized by these harmful biotic entities.Thus far, strategies employed to manage these post-harvest diseases and mycotoxins decontamination include established physical, cultural, and chemical methods. Recently, the application of chemicals to reduce decay and deterioration caused by various pathogens has been impeded as these hazardous chemicals contaminate the environment, enter the food chain, and destroy beneficial microorganisms and pests by aiming at non-target microorganisms. In light of this, the usage of eco-friendly and non-polluting alternatives to chemical pesticides is the call of the hour.Bio-management of Postharvest Diseases and Mycotoxigenic Fungi deals with the current state and future prospects of using various bio-management techniques that are natural, eco-friendly, and environmentally safe. It aims to increase awareness of their potential as well as sensitizing readers to the various aspects of biologicals in pest control. Key Features: Highlights classical versus new techniques adopted to manage postharvest diseases Discusses novel approaches in managing fungal spoilage and mycotoxin decontamination Provides readers with a 360-degree perspective of the pre- and post-harvest quality mycotoxin decontamination research being conducted Details proposals of new ideas to ensure a food secure and pesticide-free world This book disseminates notable and diversified scientific work carried out by leading experts in their own field. Written by qualified scientists in each of their respective disciplines, it can serve as a current and comprehensive treatise on the emerging field of bio-management of postharvest diseases and mycotoxin decontamination by products that are'generally regarded as safe.'

An A-Z encyclopedia covering all aspects of infectious diseases and their prevention, offering historical and technical background with a balanced discussion of discoveries, developments, and prognoses.

Bone Marrow Pathology has been extensively revised to reflect the significant advances which have occurred in the application of cytogenetics and in particular, molecular genetics in the diagnosis, classification and understanding of haematological disorders. This comprehensive book not only provides information on all common disease entities, but also covers rare disorders in which bone marrow examination is useful. It is designed as a practical resource with'problems and pitfalls'highlighted throughout to aid laboratory diagnosis.

Cytokine Storm Syndromes, including HLH and MAS, are frequently fatal disorders, particularly if not recognized early and treated during presentation. The genetics of Cytokine Storm Syndromes are being defined with many of the risk alleles giving rise to mutations in the perforin-mediated cytolytic pathway used by CD8 cytotoxic T cells and natural killer cells. These are being studied using murine models. Up to 10% of the general population may carry risk alleles for developing Cytokine Storm Syndromes, and Cytokine Storm Syndromes are being increasingly recognized around the world in pediatric and adult hospitals. A variety of infectious, rheumatic, and oncologic triggers are commonly associated with Cytokine Storm Syndromes, but understanding this disorder is critical for all researchers and physicians to ensure timely and appropriate therapy. This textbook, the first of its kind, addresses all aspects of the disorder – from genetics, pathophysiology, and ongoing research,to clinical presentations, risk factors, and treatment.

This text provides a state-of-the-art overview on Non-Hodgkin's lymphoma (NHL) in children and adolescents. The volume is divided into seven sections, each of which focuses on a critical component of pediatric NHL, including history and epidemiology, pathology and molecular biology, disease evaluation and response, common and rare sub-types of NHL, and current and novel treatment strategies. The text also comprehensively reviews the late effects of treatment, quality of patient life, and NHL treatment in countries with limited resources.Written by experts in the field, Non-Hodgkin's Lymphoma in Childhood and Adolescence is a valuable resource for clinicians and practitioners who treat children and adolescents with NHL.

This book provides a comprehensive, state-of-the art review of hematopoietic stem cell transplantation (HSCT) for sickle cell disease (SCD). The book reviews new data about risk prediction for severe SCD, outlines the unique challenges of HSCT for patients with SCD, profiles the supportive care guidelines for patients who are undergoing HSCT, highlights our current understanding of the best transfusion support for SCD patients prior to, during and after HSCT, and provides new perspectives about the ethics of HSCT for pediatric patients with SCD. Published in the last few years, several landmark phase III trials that utilize matched unrelated and haploidentical donors for HSCT in SCD patients are also placed in context with respect to current management. Written by experts in the field, Sickle Cell Disease and Hematopoietic Stem Cell Transplantation is a valuable resource for physicians and researchers dealing with and interested in this challenging, yet exciting, curative therapy for sickle cell disease, that will help guide patient management and stimulate investigative efforts.

The Ninth Edition of An Introduction to Community & Public Health provides the latest trends and statistics in community health. With an emphasis on developing the knowledge and skills necessary for a career in health education, this best-selling introductory text covers such topics as epidemiology, community organization, program planning, minority health, health care, mental health, environmental health, drugs, safety, and occupational health.

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In light of public concerns about sustainable food production, the necessity for human and environmental protection, along with the evolution of herbicide resistant weeds, call for a review of current weed control strategies. Sustainable weed control requires an integrated approach based on knowledge of each crop and the weeds that threaten it. This book will be an invaluable source of information for scholars, growers, consultants, researchers and other stakeholders dealing with either arable, row, cash, vegetables, orchards or even grassland-based production systems. The uniqueness of this book comes from the balanced coverage of herbicide effects on humans and environment in relation to best weed control practices of the most important cropping systems worldwide. Furthermore, it amalgamates and discusses the most appropriate, judicious and suitable weed control strategies for a wide range of crops. It reviews the available information and suggests solutions that are not merely feasible but also optimal.

This book presents an in depth study of different aspects of pesticide use in food production. The text covers the sources of pesticide residues in foods, relevant health and environmental concerns, degradation of pesticides after their use, and available laws and regulations to regulate pesticide use. In addition, different pesticide management techniques, such as: reduction of pesticide residues in grains and foods, alternatives to conventional pesticides, and prospects of organic farming are also covered.Pesticide Residue in Foods: Sources, Management, and Control aims to raise awareness of the proper use of these chemicals in order to lower residue in foods and reduce risk for consumers.

Now with a new full color design and art program, the Eighth Edition of An Introduction to Community & Public Health provides the latest trends and statistics in community health. With an emphasis on developing the knowledge and skills necessary for a career in health education, this best-selling introductory text covers such topics as epidemiology, community organization, program planning, minority health, health care, mental health, environmental health, drugs, safety, and occupational health. A robust pedagogy helps students understand and retain key learning objectives and better prepare for class.

How we produce and consume food has a bigger impact on Americans'well-being than any other human activity. The food industry is the largest sector of our economy; food touches everything from our health to the environment, climate change, economic inequality, and the federal budget. From the earliest developments of agriculture, a major goal has been to attain sufficient foods that provide the energy and the nutrients needed for a healthy, active life. Over time, food production, processing, marketing, and consumption have evolved and become highly complex. The challenges of improving the food system in the 21st century will require systemic approaches that take full account of social, economic, ecological, and evolutionary factors. Policy or business interventions involving a segment of the food system often have consequences beyond the original issue the intervention was meant to address. A Framework for Assessing Effects of the Food System develops an analytical framework for assessing effects associated with the ways in which food is grown, processed, distributed, marketed, retailed, and consumed in the United States. The framework will allow users to recognize effects across the full food system, consider all domains and dimensions of effects, account for systems dynamics and complexities, and choose appropriate methods for analysis. This report provides example applications of the framework based on complex questions that are currently under debate: consumption of a healthy and safe diet, food security, animal welfare, and preserving the environment and its resources. A Framework for Assessing Effects of the Food System describes the U.S. food system and provides a brief history of its evolution into the current system. This report identifies some of the real and potential implications of the current system in terms of its health, environmental, and socioeconomic effects along with a sense for the complexities of the system, potential metrics, and some of the data needs that are required to assess the effects. The overview of the food system and the framework described in this report will be an essential resource for decision makers, researchers, and others to examine the possible impacts of alternative policies or agricultural or food processing practices.

Selected, peer reviewed papers from the 2014 5th International Conference on Information Technology for Manufacturing Systems (ITMS 2014), September 16-17, 2014, Singapore

Selected, peer reviewed papers from the 2013 2nd International Symposium on Manufacturing Systems Engineering (ISMSE 2013), July 27-29, 2013, Singapore

What changes are occurring at the macro and the sectoral levels, how the labour market changes are taking place and what impact is felt on the low income households are some of the questions that the present volume focuses on. It begins by examining the sectoral composition of growth, revisiting the issues related to industry-services balance, and also brings out the spatial dimension of growth. On the one hand the industry does not seem to have played a major role in the context of employment generation as imported technology is by and large capital intensive in nature. On the other hand, the services-led growth is seen to have reduced the pace of poverty reduction. Given the services-led growth the possible impact of trade in services on employment both in the formal and informal sectors have been worked out, indicating limited positive spill-over effects. The labour market outcomes are brought out with great details suggesting that rapid economic growth in India could not result in productive employment generation on a large scale. The gender dimensions of employment are brought out to verify if reduction in labour market inequality can result in improving the position of women in other spheres encompassing the decision making process both within the household and outside the household. Issues relating to urbanisation and rural-urban migration are also covered to understand the dynamics of urban poverty and to bring out the challenges of population transfer given the spatial concentration of growth. The job search practices pursued by the low income households are often pursued in terms of informal networks. What problems are associated with such mechanisms in experiencing improvements in wellbeing levels are covered in the present volume. On the whole, the volume offers an explanation of limited poverty reduction in a situation of rapid economic growth on the basis of an inter-disciplinary framework though efforts are being made to keep the methodology quantitatively rigorous.

In 1992 world leaders met at the Earth Summit in Rio de Janeiro to reaffirm the Declaration of the United Nations Conference on the Human Environment that was established on June 16, 1972 in Stockholm. The meeting resulted in the adoption of Agenda 21 by the member states which is a framework for the transition to a more sustainable world. In 2012 the members gathered to assess and reaffirm the importance of progress towards the efforts of Agenda 21. In response to this the Institute of Medicine's (IOM's) Roundtable on Environmental Health Sciences, Research, and Medicine held a workshop to inform the policies that are discussed at the 2012 Earth Summit. The workshop, held in Woods Hole, Massachusetts on July 25-26, 2011, focused on the issue of sustainability and health as well as the linkages that are currently present between the two. The workshop included presentations and discussions which are summarized in Public Health Linkages with Sustainability: Workshop Summary. The report presents how different areas of public health, such as food and water resources, link to sustainability and opportunities or venues that can be examined.

Selected, peer reviewed papers from the ROBTEP 2012, 14th – 16th November 2012, Strbske pleso, High Tatras, Slovakia

The second part of the'Seismicity of the European Area'contains further results of the survey of European seismicity, performed during the period 1959 -1967. It was intended to publish the second part with the shortest possible delay. The first part appeared in 1968 when the manuscript of the second part was handed over to the publisher. Unfortunately, due to unexpected technical difficulties the publica­ tion had to be postponed until the end of 1970. Thus the manuscript reflects the state of knowledge corresponding to the year 1967 when the work on the manuscript was concluded. It was only possible to make minor changes, or to insert additional, very brief information into the catalogue Prague, July 20, 1970 Vit Karnik CONTENTS 1. 1. Introduction 7 1. 2. Source literature 9 2. Earthquake catalogue 1801-1900 11 2. 1. Earthquake parameters 12 2. 11. Date, time of origin 12 2. 12. Epicentre coordinates 12 2. 13. Epicentral intensity 13 2. 14. Description of macro seismic effects, foreshocks, aftershocks 14 2. 2. Statistical tables 15 2. 3. Supplementary catalogues for the years prior to 1801 and after 1955 17 2. 4. Catalogue of Earthquakes 1801-1900, 10 ~ VII 19 2. 41. Earthquake catalogue of the European and Mediterranean area, unidentified names of localities 114 2. 42. References to the catalogue of shocks 1801-1900 117 3. Some characteristics of seismic activity 123 3. t. Discussion of the magnitude-frequency relation 123 3. 11.

Covers all aspects of infectious diseases and their prevention, offering historical and technical background with a balanced discussion of discoveries, developments, and prognoses.

Selected, peer reviewed papers from the 4th Manufacturing Engineering Society International Conference, September 2011, Cadiz, Spain

Intracellular cell signaling is a well understood process. However, extracellular signals such as hormones, adipokines, cytokines and neurotransmitters are just as important but have been largely ignored in other works. They are causative agents for diseases including hypertension, diabetes, heart disease, and arthritis so offer new, and often more approachable, targets for drug design. Aimed at medical professionals and pharmaceutical specialists, this book integrates extracellular and intracellular signalling processes and offers a fresh perspective on new drug targets. Written by colleagues at the same institution, but with contributions from leading international authorities, it is the result of close cooperation between the authors of different chapters. Readers are introduced to a new approach to disease causation by adipokines and toxic lipids. Heart disease, migraines, stroke, Alzheimer's disease, diabetes, cancer, and arthritis are approached from the perspective of prevention and treatment by alteration of extracellular signalling. Evidence is presented that the avoidance of toxic lifestyles can reduce the incidence of such illnesses and new therapeutic targets involving adipokines, ceramide and endocannabinoids are discussed.

G protein-coupled receptors (GPCRs) are the largest family of cell-surface receptors, with more than 800 members identified thus far in the human genome. They regulate the function of most cells in the body, and represent approximately 3% of the genes in the human genome. These receptors respond to a wide variety of structurally diverse ligands, ranging from small molecules, such as biogenic amines, nucleotides and ions, to lipids, peptides, proteins, and even light. Ligands (agonists and antagonists) acting on GPCRs are important in the treatment of numerous diseases, including cardiovascular and mental disorders, retinal degeneration, cancer, and AIDS. It is estimated that these receptors represent about one third of the actual identified targets of clinically used drugs. The determination of rhodopsin crystal structure and, more recently, of opsin, 1 and 2 adrenergic and A2A adenosine receptors provides both academia and industry with extremely valuable data for a better understanding of the molecular determinants of receptor function and a more reliable rationale for drug design. GPCR structure and function constitutes a hot topic. The book, which lies between the fields of chemical biology, molecular pharmacology and medicinal chemistry, is divided into three parts. The first part considers what receptor structures tell us about the mechanism of receptor activation. Part II focuses on receptor function. It discusses what the data from biophysical and mutational studies, and the analysis of the interactions of the receptor with ligands and regulator proteins, tell us about the process of signal transduction. The final part, on modelling and simulation, details new insights on the link between structure and mechanism and their implications in drug design.

th This volume contains the papers selected for the 13 FIRA Robot World Congress, held at Amrita Vishwa Vidyapeetham Bangalore, India, September 15-17, 2010. The Federation of International Robot-soccer Association (FIRA – www.fira.net) is a non-profit organization that annually organizes robotic competitions and meetings around the globe. The robot soccer competitions started in 1996, and FIRA was est- lished on, June 5, 1997. The robot soccer competitions are aimed at promoting the spirit of science and technology to the younger generation. The congress is a forum to share ideas and future directions of technologies, and to enlarge the human networks in the robotics area. The objectives of the FIRA Cup and Congress are to explore the technical dev- opments and achievements in the field of robotics, and provide participants with a robot festival including technical presentations, robot soccer competitions, and exh- its under the theme “Where Theory and Practice Meet.” FIRA India aims to propagate and popularize robotics and robotic competitions across India.

H1N1 ('swine flu'), SARS, mad cow disease, and HIV/AIDS are a few examples of zoonotic diseases-diseases transmitted between humans and animals. Zoonotic diseases are a growing concern given multiple factors: their often novel and unpredictable nature, their ability to emerge anywhere and spread rapidly around the globe, and their major economic toll on several disparate industries. Infectious disease surveillance systems are used to detect this threat to human and animal health. By systematically collecting data on the occurrence of infectious diseases in humans and animals, investigators can track the spread of disease and provide an early warning to human and animal health officials, nationally and internationally, for follow-up and response. Unfortunately, and for many reasons, current disease surveillance has been ineffective or untimely in alerting officials to emerging zoonotic diseases. Sustaining Global Surveillance and Response to Emerging Zoonotic Diseases assesses some of the disease surveillance systems around the world, and recommends ways to improve early detection and response. The book presents solutions for improved coordination between human and animal health sectors, and among governments and international organizations. Parties seeking to improve the detection and response to zoonotic diseases—including U.S. government and international health policy makers, researchers, epidemiologists, human health clinicians, and veterinarians—can use this book to help curtail the threat zoonotic diseases pose to economies, societies, and health.

Why a new book on angiogenesis and why now? For the first time concepts proposed over 30 years ago have found clinical validation. In the last two years the first antiangiogenic agents have been approved by the FDA for the treatment of cancer and age-related macular degeneration. Not surprisingly, this clinical success has raised a new set of basic

This book constitutes the joint refereed proceedings of six workshops, EvoWorkshops 2003, held together with EuroGP 2003 in Essex, UK in April 2003. The 63 revised full papers presented were carefully reviewed and selected from a total of 109 submissions. In accordance with the six workshops covered, the papers are organized in topical sections on bioinformatics, combinatorial optimization, image analysis and signal processing, evolutionary music and art, evolutionary robotics, and scheduling and timetabling.

Solid catalysts play a fundamental role in all areas between basic research and industrial applications. This book offers a large amount of information about the preparation of solid catalysts. All types of solid catalysts and all important aspects of their preparation are discussed. The highly topical contributions are written by leading experts in disciplines ranging from solid state, interface and solution chemistry to industrial engineering. The straightforward presentation of the material and the comprehensive coverage make this book an essential and indispensible tool for every scientist and engineer working with solid catalysts.