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The knowledge base required of the modern-day head and neck surgeon, as a key member of a comprehensive and wide-ranging multidisciplinary team, is significant. The sixth edition of Stell & Maran's Head and Neck Surgery and Oncology continues to be the leading reference book in the specialty.This accessible and authoritative text is fully revised and updated to reflect international practice across the multidisciplinary team. A global community of expert authors have provided chapters entailing the expertise required by today's head and neck surgeon. The book encompasses fundamentals of head and neck oncologic practice including pathology, imaging, staging, prehabilitation, surgical approaches and reconstruction, radiation therapy, chemotherapy, biological therapies and many more. Key sections discuss the broad range of tumours by anatomical site and rare cancers. Future perspectives are reviewed with topics on how to become a clinical trialist, delivering surgical innovation and personalised approaches to head and neck cancer therapy with insights for the future.With contributions from the full spectrum of the multidisciplinary team, this book will be a major up-to-date resource for both trainees and established practitioners in otolaryngology, maxillofacial surgery, plastic surgery, endocrine surgery, clinical oncology, oncology nursing and those professions allied to medicine, such as speech and language therapy and dietetics.

This edited book includes over one hundred and eighty short papers that were presented during the third edition of EMCEI, which was held in Sousse, Tunisia, in June 2021. Nowadays, experts as well as most of the general public know that the Mediterranean and surrounding regions are facing environmental degradation that is accelerating at an unprecedented rate. The main causes are the natural and human induced climate change, increasing pollution, urban growth, and the overexploitation and unsustainable use of resources due to rapid population growth. The effects are seen in several indicators such as the warming, more frequent extreme events, severe droughts, water shortages, contraction of natural resources, changes in land use and landscape deterioration, decreasing agricultural yields, biodiversity loss, deterioration of the ecosystems, corrosion of the natural coastal environment, sea-level rise, and ocean acidification. In addition to these more recent issues, the Mediterranean and surrounding region naturally experience a number of hazards such as floods, droughts, desertification, fires, catastrophic forest diebacks, earthquakes, and volcanic eruptions. By presenting a wide range of environmental topics and new findings relevant to a variety of problems in these regions, this book appeals to anyone working in the subject area and especially students interested in learning more about new developments in environmental research initiatives in light of the worsening environmental degradation of the Mediterranean and surrounding areas, making environmental and resource protection an increasingly important issue that impedes sustainable development and social well-being. The book addresses emerging environmental issues along with new challenges by focusing on innovative approaches that contribute to achieving a sustainable environment in and around the Mediterranean Sea and by highlighting to decision makers from relevant sectors the environmental considerations that should be integrated into their own activities.

Archaeology of Body and Thought explores what we as people can do with our bodies, what we can use them for, and how we can alter and understand them. It considers the ways in which individual human groups from the Neolithic to the Migration Period have perceived and treated the body. The analysis is based on artefacts found in graves, anthropomorphic images, and written sources, with an underlying assumption that principles of aesthetics or a canon of beauty express a way of understanding and evaluating corporality commonly adopted in a given culture. From this perspective, the human body is also an archaeological artefact and a specific kind of material culture (indeed, the most important one). The book investigates the extent to which ideology shapes our bodies and how our bodies create our world outlook. To that end, it compares bodies with other contemporary spheres of material culture and technology. Geographically, the study concentrates on central and eastern Europe, a region where various cultural trends have always intersected. Greece, Italy, Scandinavia, and Eurasian steppes are also included in the analysis.

Comprehensive Precision Medicine holistically integrates essential and interconnecting disciplines that contribute to the make-up of Precision Medicine as we know it today. Encompassing almost 90 contributions from eminent scholars and professionals, the book's contents are organized across 3 volumes and 7 major subject areas, each representing a key pillar driving the evolution and progression of healthcare delivery. Precision medicine approaches will transform the training and practice of all aspects of professional healthcare delivery, including medicine, nursing, pharmacy, psychology, rehabilitation, and social work. This will be a fundamental reference resource for students, post-graduate trainees, researchers, scientists and clinicians interested in precision medicine. Additionally, this resource will be of interest to regulators, policy makers, and public health practitioners across the globe. - Provides comprehensive coverage and is basically a'one-stop'resource across all disciplines contributing to precision medicine - Authoritative guide edited by distinguished authorities who are shaping the advancement of precision medicine - Thematically organized, allowing for easy exploration across interconnecting disciplines - Digitally innovative resource with multimedia features that complement the text and provide additional learning and teaching resources

This new edition presents a state-of-the-art exploration of polarized light and polarization vision. Part I of the book examines polarization sensitivity across many animal taxa, including invertebrates and vertebrates, and it details both terrestrial and aquatic life. Part II is devoted to the description of environmental polarization with implications to animal and human polarization vision. This includes underwater polarization, polarization signals, sky-polarimetric Viking navigation and astronomical polarization. This part also examines polarized light pollution induced by anthropogenic factors, such as reflection off asphalt surfaces, glass panes, car bodies, and other man-made structures that are now known to form ecological traps for polarotactic insects. The new edition features a number of novelties, including chapters on trilobites, springtails, bats, seals, imaging polarimetry, and astronomical polarization.

Treatise on Estuarine and Coastal Science is the most up-to-date reference work for system based coastal and estuarine ecosystem science and management. It addresses the big issues facing the estuaries and coastal zone; in particular how to best use multi- and inter-disciplinary science to ensure the sustainability of the environment. It focusses on the need to protect and maintain the natural functioning of the estuaries and coasts worldwide while delivering the ecosystem services from which society extract goods and benefits.Structured chapters, written by leaders in the field, include reference lists and additional reading, copious diagrams, case-studies, and especially provide synthesis diagrams and conceptual models of complex issues. The Treatise covers both the natural and social sciences, serving a wide audience which ranges from undergraduate students to established researchers and practitioners.The work avoids autecological studies but focusses on inter-linked physical-chemical-biological-ecosystem processes and associated socio-economic issues in the coastal zone. It examines estuaries and coasts, and their interactions and feedbacks with humanity, from the inland catchment/river basin to the ocean shelf.The new edition builds on and expands the previous version with significant updates and a whole new section on Climate Change and Coastal Ecosystems, covering the resistance and resilience of the estuaries, coasts and other transitional habitats to climate change, thereby determining changes and responses needed over the coming decades. - Comprehensive – a unique resource in the field, Treatise on Estuarine and Coastal Science covers system based coastal and estuarine science and management, linking physical, chemical and biological ecosystem processes with associated socio-economic issues. - Highly regarded: the previous edition was very well received by the market and widely used, with over 50,000 chapter downloads. - Updated and forward-looking: the new edition expands the previous version with significant updates and a whole new section on Climate Change and Coastal Ecosystems, covering the resistance and resilience of the estuaries, coasts and other transitional habitats and responses needed over the coming decades. - Authoritative and accessible – 155 chapters, written by leaders in the field, provide synthesis and conceptual models of complex issues, ensuring that the knowledge within is easily understood by a large audience. - Structured content - all chapters follow a common structure with set headings, making it easier for users to cross-compare and navigate the content.

Early diagnosis of HNSCC can cause improved treatment, treatment response rates and reduction in mortality rates. Recently, miRNA-based diagnostics and therapeutics have gained considerable attention among the scientific community. MiRNAs are known to have great potential as biomarkers for early diagnosis, prediction, and prognosis of HNSCC, and play a role in development of targeted gene therapy.Diagnostic, Prognostic and Therapeutic Role of MicroRNAs in Head and Neck Cancer provides detailed information on various miRNA-based approaches for diagnosis, prognosis, and treatment of HNSCC. It encompasses various miRNA-based point of care diagnostics and drug delivery systems for HNSCC along with the information on the clinical trials of miRNAs for improved clinical outcomes in HNSCC patients. The book provides a comprehensive overview of currently available miRNAs associated with HNSCC and their extensive application for early diagnosis, prognosis, and treatment. This book will help scientists and clinicians to win the battle against HNSCC. - Covers the role of the tumor microenvironment in head and neck cancer - Provides information on oncogenic and tumor suppressor miRNAs dysregulated in HNSCC patients - Elucidates the role of miRNAs in metastasis, recurrence, and chemoresistance in HNSCC - Includes the current state-of-art in miRNA-based clinical trials for head

Environmental conditions and processes are one of the major pillars on which the human well-being rests. It is the core responsibility of the society to preserve and enhance better conditions for the human well-being. Indeed, there are several evolving unmet needs in public health. Emerging and re-emerging infectious diseases and a surge in the incidence of non-communicable diseases, including cardiovascular diseases (CAD), chronic respiratory diseases, and metabolic diseases have been impediments to sustainable well-being. Many factors are critical in the global surge in the rate and incidence of cardiovascular diseases. These include the shift from acute to chronic conditions, the shift from single risk factor vs. multiple influences, aging population, global health disparities, exposure to lower harmful influences over a longer period, etc. However, the epigenetic factors due to unhealthy environment play a most significant role in the underlying pathogenesis of cardiovascular diseases. Unfortunately, this has been ignored for a long time and realized lately to expand and disseminate knowledge to general population, expand research activities to investigate the cellular and molecular mechanisms, and develop better preventive and treatment strategies. The most significant environmental impoverishment in the pathogenesis of cardiovascular diseases include different genetical, chemical, physical, and biological influences, but not limited to, socio-economic status and lack of nutrients, nutritional aspects including habits, diets and additives, inhaled and ingested pollutants, exhaust gas and gasoline products, tobacco smoke, water pollution, alcohol consumption, soil and mineral pollution, solvents, pesticides, microplastics, non-critical usage of drugs, climate change, extreme atmospheric conditions, extremes in noise and temperature, electromagnetic influences, microwaves and radiation, outdoor light pollution, mental stressors, lack of or over exercise, microbiota and microbiological agents like SARS CoV-2 virus, etc.

This book presents recent advancements, challenges, and clinical implications of molecular biomarkers in various cancers. This book highlights the clinical applications of biomarkers are extensive for cancer risk assessment, screening and early detection of cancer, accurate diagnosis, patient prognosis, prediction of response to therapy, and cancer surveillance and monitoring response. It also explores the progress of predictive biomarkers as an adjunctive tool to tumor immunotherapy in effectively identifying the efficacy of immune checkpoint inhibitors and discusses their future directions in achieving precision immuno-oncology. Further, the book examines the combination of next-generation sequencing and advanced computational data analysis approaches in the understanding of the genomic underpinnings of cancer development and progression. Towards the end, the chapter discusses the role of some commonly investigated phytochemicals and their epigenetic targets that are of particularinterest in cancer prevention and cancer therapy. It is a must for researchers as well as advanced students and physicians in the field of cancer and clinical oncologists.

Comprehensive resource on the science of autoimmune disorders, covering causes, treatment, prevention, and the latest research in the field Autoimmune Disorders is an authoritative reference on the science of autoimmune disorders, covering their causes, including infections, vaccine adjuvants, environmental stimuli, and silicone implants, the latest research on the genetics, epigenetics, and immunology of autoimmunity, predictive markers, therapeutic approaches for treatment and prevention, and suggestions for future research directions. This book explores the intricate connections between adjuvants and autoimmune responses, focusing on the emergence of the Autoimmune/Inflammatory Syndrome Induced by Adjuvants (ASIA syndrome), as well as autoimmune connections in areas such as chronic fatigue syndrome, autoantibodies targeting the autonomic system, and small fiber neuropathy. The authors emphasize the profound impact of vaccines on public health, underscoring that their benefits far outweigh potential side effects and exploring the historical context of adjuvants in vaccine development. From tattoos to environmental factors, each chapter adds a unique thread to the tapestry of adjuvants, autoimmune responses, and their interactions. Sample topics covered in Autoimmune Disorders include: Food additives and dental implants as a trigger of autoimmunity and increased risk of ASIA syndrome as a result of the chemical and social factors Sustained immune activation in ASIA syndrome as a bridge to lymphomagenesis and how immune checkpoints, metals, and bisphenol connect to autoimmunity Postural Orthostatic Tachycardia syndrome (POTS), Sick Building syndrome, and Gulf War syndrome (GWS) as parts of ASIA syndrome Sarcoidosis and Sjögren's syndrome as a proof of concept of hyperstimulation syndrome Autoimmune Disorders is an essential reference on the subject for academics, specialized postgraduate students, and practicing professionals seeking to improve integrated research strategies and foster a deeper understanding of the complex relationship between immunology, public health, and individual well-being.

Encyclopedia of Quaternary Science, Third Edition, Six Volume Set brings together the multidisciplinary expertise needed to understand the history of humans, life, environmental, and climate change to understand what we may expect over the coming decades. Since publication of the previous edition, our understanding of many topics has been revolutionized by new discoveries and new techniques. The development of ancient DNA studies, for example, has revolutionized our thinking about the origins, dispersal, and population dynamics of our ancestors. Every new aDNA analysis from ancient human remains causes the story to become more complex. We are the sole survivors of the genus Homo, yet we harbor genetic fragments from other closely related but long-extinct lineages. The Quaternary is uniquely situated as a laboratory in which to study the shaping of the modern world, including biotic responses to large-scale environmental change. This new edition of this book is the most comprehensive account of state-of-the-art research in this field. - Revised and expanded, this new edition brings the science up-to-date by featuring advances in all the multi-disciplinary aspects of Quaternary science - Focuses new content on numerical modeling for paleoclimate and ice-sheet reconstructions, which have greatly advanced since publication of the Second Edition - Covers ancient DNA, which has revolutionized our knowledge of human origins and dispersals, plant and animal population genetics, and more - Includes short, structured chapters, which help readers finding the information they need and save time

Dieser Band führt in systematischer Form in die grundlegenden Konzepte und Methoden der Prähistorischen Archäologie ein. Unter Berücksichtigung forschungsgeschichtlicher Aspekte werden Struktur und erkenntnistheoretische Voraussetzungen eines Faches entwickelt, dessen Quellen im Wesentlichen aus nichtschriftlichen Hinterlassenschaften bestehen. Die hier erstmals umfassend erörterten Konzepte und Methoden sind jedoch nicht nur für die Ur- und Frühgeschichtswissenschaft, sondern für die Archäologie insgesamt von zentraler Bedeutung. Für diese fünfte Auflage wurde das bewährte Standardwerk erneut überarbeitet und aktualisiert. „Welche andere Einführung verpflichtet zur kritischen Lektüre grundlegender Werke so sehr wie die ‚Prähistorik‘ Eggerts?“ Fundberichte aus Baden-Württemberg 26, 2002 - (Dr. Michael Strobel)

Prehistoric Flint Mines in Europe presents the results of the UISPP Commission, Flint Mining in Pre- and Protohistoric Europe. It offers a review of major flint mines dating from the Neolithic to the Bronze Age. The eighteen articles were contributed by archaeologists from ten countries – Belgium, France, Germany, Great Britain, Hungary, Italy, the Netherlands, Poland, Spain and Sweden – using the same framework in order to propose a uniform view of the mining phenomenon. At the same time the book reflects various research methods and traditions. Each article deals successively with the geographical and geological context, mining zone topography, research history, methods of exploitation of raw material, dating of archaeological features and structures, characteristics of lithic production, organization of labour, miners'settlements, distribution of products and symbolic aspects of mining activity. Part I includes the well-known flint mines at Spiennes in Belgium, Grime's Graves in England and Rijckholt-Sint Geertruid in the Netherlands, as well as the equally fascinating Defensola mine from Italy. Part II contains presentations of other European flint mines. The book is abundantly illustrated with large, colour photographs and drawings, and is aimed not only at archaeologists, who will find valuable data and further literature, but also at any reader seeking up-to-date information on prehistoric flint mining communities in Europe.

The third volume of the Homines, Funera, Astra series gathers works presented at the third and fourth editions of the International Symposium on Funerary Archaeology: Death and Fire in Ancient Times (15–18 September 2013), and Time and Cause of Death from Prehistory to the Middle Ages (21–23 September 2014), both held at the ‘1 Decembrie 1918'University in Alba Iulia, Romania. The contributions focus on two central topics regarding past funerary behaviour in Central and South-Eastern Europe: cremation, and cause and time of death. As in previous volumes, interdisciplinarity is a key feature. The study of archaeological contexts through 14C dating and Bayesian modelling, osteological studies including palaeopathologies, and epigraphic and numismatic evidence were all taken into account to establish the various causes of death and/or the moment these tragic events took place. The present volume includes 13 studies, six of which are dedicated to prehistoric funerary practices – dating to the Neolithic and Eneolithic periods (four studies), Bronze Age (one study) and Iron Age (one study). Three more papers are focused on the Roman Age, while the volume is completed with four papers on the Medieval period, overall providing a wealth of new information on funerary behaviour in this part of Europe.

Encyclopedia of Cell Biology, Second Edition, a Six Volume Set, has established itself as a fundamental reference work, providing broad coverage of the field in four main sections (Molecular, Organizational, Functional, Translational and Pathological Aspects of Cell Biology). This second edition revisits and expands each section, with entries on topics not covered in the first edition, including Crispr. The whole work is updated, providing greater coverage of specialized cell function and translational applications, and putting greater emphasis on these topics in graduate/medical teaching. New overview chapters and subsections provide a simplified cell biology text that can be used by instructors. The new version includes a standard template for each chapter, making the content easier to navigate, as well as inserts and graphics which provide summaries of key points in each chapter. - Provides the authority of a team of outstanding scientists in the field - Presents a comprehensive, up-to-date resource, covering both basic and translational aspects of cell biology - Offers high quality content at a competitive market price

Groundwater Ecology and Evolution, Second Edition is designed to meet a multitude of audience needs. The state of the art in the discipline is provided by the articulation of six sections. The first three sections successively carry the reader into the basic attributes of groundwater ecosystems (section 1), the drivers and patterns of biodiversity (section 2), and the roles of organisms in groundwater ecosystems (section 3). The next two sections are devoted to evolutionary processes driving the acquisition of subterranean biological traits (section 4) and the way these traits are differently expressed among groundwater organisms (section 5). Finally, section 6 shows how knowledge acquired among multiple research fields (sections 1 to 5) is used to manage groundwater biodiversity and ecosystem services in the face of future groundwater resource use scenarios. Emphasis on the coherence and prospects of the whole book is given in the introduction and conclusion. - Provides a modern synthesis of research dedicated to the study of groundwater biodiversity and ecosystems - Bridges the gap between community ecology, evolution, and functional ecology, three research fields that have long been presented isolated from each other - Explains how this trans-disciplinary integration of research contributes to understanding and managing of groundwater ecosystem functions - Reveals the contribution of groundwater ecology and evolution in solving scientific questions well beyond the frontiers of groundwater systems

An extensive study of the origins and culture of the mysterious Huns and the civilizations affected by their invasions. The first part of the book deals with the political history of the Huns, however, they are not a narrative. The second part of the book consists of monographs on the economy, society, warfare, art, and religion of the Huns. What distinguishes these studies from previous treatments is the extensive use of archaeological material. This title is part of UC Press's Voices Revived program, which commemorates University of California Press's mission to seek out and cultivate the brightest minds and give them voice, reach, and impact. Drawing on a backlist dating to 1893, Voices Revived makes high-quality, peer-reviewed scholarship accessible once again using print-on-demand technology. This title was originally published in 1973.

「ヨコエビ」というマイナーな生物は、じつは面白い秘密に満ちあふれている。名前に「エビ」と付いているものの、エビとは全く別種で、生物としてはむしろダンゴムシやフナムシなどに近い。また生態系では、両生類や昆虫のほか、タイやサケなどの魚介類の主要な餌として重要な役割を担っている。自然界だけでなく、私たちの食卓もヨコエビに支えられているのだ。そして、マリアナ海溝のような深海から標高5,000メートルをこえるヒマラヤの氷河湖まで、地球上のあらゆる場所にたくさんの種類がすんでいる。なぜ、これほどまでに繁栄しているのか？ 本書ではヨコエビに関する数々の秘密を探ることで、その理由に迫っていく。 身近なところでも海岸や湧き水など、ヨコエビはさまざまな環境に生息しており、面白い行動も観察できるため、自由研究や探究的な学習材料としても優れている。巻末には、中学校や高等学校での課題研究やクラブ活動などに役立つヨコエビの調べ方についても収録した。

This book provides a broad overview of the current research questions facing archaeologists working in Europe. The book uses a case-study method in which a number of archaeologists discuss their work and reflect on their goals and approaches. The emphasis is on the intellectual process of archaeology, not just the techniques and results. Chronological coverage is provided from the Mesolithic to the Iron Age and over much of the European continent.

This edited volume is dedicated to national-socialist archaeology as a Europe-wide phenomenon. It analyses national-socialist attempts to denationalize the archaeologies of European nations by creating a new unifying European archaeology on a racial basis. From the beginning of the nineteenth century, archaeology began to develop into an important force behind processes of nation building. At the same time, structures of transnational academic collaboration contributed strongly to the internal dynamics of the research field, which was primarily organized on a national basis. In those European countries that were confronted with national-socialist occupation and repression between 1939 and 1945, these transnational archaeological networks were to prove crucial for the development of national-socialist archaeological policies. This volume will reveal how national-socialist archaeology was to anextent valued positively in its time as highly innovative, even influencing the archaeology of non-occupied countries. Although in the final instance, it generally failed to displace the national archaeologies in Europe, the volume also analyses the long-term impact of national-socialist rule on the development of European archaeology. How did the attempts to create a unified European archaeology after 1945 continue to influence networks, methods and terminologies, institutional structures, or popular representations of the early past? Chapter “1” Is available open access under a Creative Commons Attribution 4.0 International License via Springerlink.

Identification and Ecology of Freshwater Arthropods in the Mediterranean Basin covers the entire Mediterranean basin, including parts of Europe, Asia, Africa and the Mediterranean islands, but excluding other biogeographic locations with Mediterranean climates located outside the region. The book provides an extensive description of the taxonomy and ecology of aquatic arthropods encountered in lentic and lotic habitats, as well as in less studied underground and estuarine habitats. It offers expanded taxonomic identification keys to major groups of arthropods with a description of their ecology and distribution. Keys for insects include aquatic larval stages and water-dwelling adults of Coleoptera and Heteroptera. Additional sections focus on taxa that can be encountered in adjacent brackish and estuary ecosystems as long as the taxon primarily occurs in freshwaters. This is a much-needed, comprehensive resource on the taxonomy and ecology of freshwater arthropods with an introduction to recent molecular tools for identifications. It will be particularly useful for freshwater ecologists, limnologists, environmentalists and students in the ecological sciences. - Presents taxonomic keys to genera and species to the majority of aquatic arthropod families - Provides coverage of all freshwater ecosystems of the Mediterranean basin, with case studies and examples - Includes numerous photographs of the aquatic arthropods described in the chapters - Covers the ecology and taxonomy of organisms living in more traditionally studied lakes and streams as well as in less studied underground and estuarine habitats

Coastal Habitat Conservation: New Perspectives and Sustainable Development of Biodiversity in the Anthropocene offers the latest research and approaches to biodiversity conservation in coastal areas. The book synthesizes the background of foundational conservation views and provides new perspectives and recent strategies within a sustainable development context for coastal species and organic life. Written by a team of international authors with expertise in wide-ranging issues of biodiversity conservation, this book analyzes the challenges of conserving marine habitats and species that humanity faces in the Anthropocene era. Sections explore emerging and unforeseen impacts within a changing world, specifically, the marine-based conservation in the context of global change, coastal urbanization and mitigation of its environmental impacts, marine bioinvasions, conservation strategies for of out-of-sight communities like caves, habitat restoration, and the citizen science and its challenging role in monitoring conservation. - Discusses different strategies to deal with various biological and ecological impacts on coastal marine species and habitats - Offers new insights into the practices of marine conservation in the Anthropocene - Led by editors whose expertise includes marine biodiversity, marine ecology and marine habitat conservation

The Archaeology of Nucleation in the Old World explores the role of the built environment in expressing and shaping community organization and identity at prehistoric and historic nucleated settlements and early cities in the Old World. The spatial layout of large settlements results from the interaction of social, political, economic, and religious orders. Subsequent structural changes governed by the application, manipulation, and challenges of these orders yield a dynamic built environment which influences the processes of organization and identity formation. Taking advantage of advances in archaeological methods and theory that allow investigations of nucleated settlements to an extent and depth of detail that was previously impossible, the contributors to this volume address specific topics, such as how the built environment and location of activity zones help us to understand social configurations; how various scales of social units can be recognized and the resulting patterns interpreted; how collective actions contribute to settlement organization and community integrity; how changes in social relations are reflected in the development of the built environment; how cooperation and competition as well as measures to mitigate social and communication stress can be identified in the archaeological record; and how the built environment was used to express or manipulate identity.

The book presents expert assessments of modern opportunities for fisheries and aquaculture in terms of economic efficiency, the state of fishery reservoirs, and the state of ichthyocenoses. The purpose of this book is to provide interested parties (government bodies, representatives of business, science and civil society) with information about modern solutions in the field of aquatic biological resources management, the state of aquatic ecosystems and fish stocks, and modern and promising technologies in aquaculture and fisheries. The book contains an assessment of the state and recommendations for the restoration of natural aquatic ecosystems, an analysis of the state of fisheries and aquaculture in inland waters, taking into account regional characteristics, the development of a methodology for assessing freshwater fish stocks, information on advanced technologies in cage aquaculture in reservoirs and lakes and in circulation systems, data on opportunities for capacity building in small-scale fisheries, and the prospects for establishing a data and information management system for fisheries and aquaculture.

Rivers of Europe, Second Edition, presents the latest update on the only primary source of complete and comparative baseline data on the biological and hydrological characteristics of more than 180 of the highest profile rivers in Europe. With even more full-color photographs and maps, the book includes conservation information on current patterns of river use and the extent to which human society has exploited and impacted them. Each chapter includes up to 10 featured rivers, with detailed information on their physiography, hydrology, ecology/biodiversity and human impacts. Rivers selected for specific coverage include the largest, the most natural, and those most affected by humans. This book provides the most comprehensive information ecologists and conservation managers need to better assess their management and meet the EU legislative good governance targets. - Includes comparison photos of rivers, along with information on the history and management of each river - Presents summary information on hydrological, ecological and freshwater biodiversity patterns and trends of each river - Highlights environmental issues of great importance to citizens and governments, including fragmentation by dams, pollution, introduction of nonnative species and reductions in biodiversity

The Polish dispute on an adequate approach towards the Białowieża Forest has been significantly internationalised, primarily by UNESCO and the European Union. The judgment of the CJEU has not settled the substance of the dispute, although it points to a violation of EU legal standards. The authors of The Disputed Białowieża Forest: Legal Remedies for the Protection of Cross-border Properties address the dispute in a constructive and interdisciplinary manner, rather than merely expressing concern towards in situ conservation, and derive universal legal remedies from it. They conclude that in the case of unique invaluable goods, adequate individual solutions should be applied in the form of a localised agreement, open to many entities (interested states, international organisations and even socially responsible private corporations), on the condition that organisational and financial co-responsibility are accepted.

This contributed volume is dedicated towards the progress achieved within the last years in all areas of Cell Culture Engineering and Technology. It comprises contributions of active researchers in the field of cell culture development for the production of recombinant proteins, cell line development, cell therapy and gene therapy, with consideration of media development, process scale-up, reactor design, monitoring and control and model-assisted strategies for process design. The knowledge and expertise of the authors cover disciplines like cell biology, engineering, biotechnology and biomedical sciences. This book is conceived for graduate students, postdoctoral fellows and researchers interested in the latest developments in Cell Engineering.

Encyclopedia of Inland Waters, Second Edition, focuses on a variety of key areas surrounding inland waters, from the distribution of water on Earth to the properties of water, including the hydrologic cycle, the physics of water movement in lakes and rivers; it includes topics such as waterborne diseases, the metabolism of aquatic ecosystems, pollution conservation, biodiversity, pollution and cycling of chemicals. New topics cover comprehensively recent advances in the field, explaining pressures and underlying concepts and theories. - Offers readers a'one-stop', comprehensive resource for access to a wealth of information and critical summaries to fully support their research and activities in this area - Includes interdisciplinary articles written by renowned academics and practitioners from various fields and regions, thus ensuring the content provides state-of-the-art information and knowledge about the structure, functions, values, threats and management opportunities for inland water - Fills a critical gap of information in a field that has seen significant progress in past years, ranging from the structures, functions, values of, and pressures on rivers, lakes, wetlands and ground waters, to underlying concepts and theories

This book presents an overview of the current status of translating the RNAi cancer therapeutics in the clinic, a brief description of the biological barriers in drug delivery, and the roles of imaging in aspects of administration route, systemic circulation, and cellular barriers for the clinical translation of RNAi cancer therapeutics, and with partial content for discussing the safety concerns. It then focuses on imaging-guided delivery of RNAi therapeutics in preclinical development, including the basic principles of different imaging modalities, and their advantages and limitations for biological imaging. With growing number of RNAi therapeutics entering the clinic, various imaging methods will play an important role in facilitating the translation of RNAi cancer therapeutics from bench to bedside. RNAi technique has become a powerful tool for basic research to selectively knock down gene expression in vitro and in vivo. Our scientific and industrial communities have started to develop RNAi therapeutics as the next class of drugs for treating a variety of genetic disorders, such as cancer and other diseases that are particularly hard to address with current treatment strategies.Key Features Provides insight into the current advances and hurdles of RNAi therapeutics. Accelerates RNAi, miRNAs, and siRNA drug development for cancer therapy from bench to bedside. Addresses various modifications and novel delivery strategies for miRNAs, piRNAs and siRNA delivery in anticancer therapeutics. Explores the need for the interaction of hematologists,cell biologists, immunologists, and material scientists in the development of novel cancer therapies. Describes the current status of clinical trials related to miRNA and siRNA-based cancer therapy Presents remaining issues that need to be overcome to establish successful therapies.

Cytokines and Diseases will contribute to the pathogenesis, follow-up, and treatment processes of different clinical pictures and diseases in the light of current information obtained from the literature. This book aims to describe the type, effects, and kinetics of cytokine production, as well as to summarize the pathophysiology of the cytokine storm that occurs after bacterial sepsis or severe viral infection. It has been a summative review containing the most up-to-date data for academics participating in cytokine-based therapy studies, studies targeting cytokine production or effects, and clinical trials that arouse interest after the Covid-19 pandemic.

The Bronze Age is a time of increasing interaction with large-scale connections that cover vast parts of Europe. Some parts and regions of the Bronze Age are very well explored and for some very strong narratives of hierarchisation and differentiation, dependence on external raw material supplies and specialisation have been proposed. In other regions, however, only some of these aspects appear, even though networks of contact would at least have been possible. This is the case in the Baltic area, where western and eastern regions show dramatic differences in subsistence, the amounts of metal produced and deposited (and therefore presumably the social role of metal), the settlement pattern and scale of social groups. A particularly interesting question is the intensity of culture contact that the eastern Baltic regions entertained across the sea with Scandinavia and also with directly neighbouring continental regions. This volume brings together scholars from all regions around the Baltic Sea to discuss different aspects of Bronze Age interactions. It offers a perspective on regional and interregional connectivity and exchange beyond the usual large-scale models discussed in Bronze Age archaeology and includes both case studies of individual regions or finds categories and broader overview papers focusing on the diversity of interconnections − and their sometimes striking absence.

This work is an intensive study of the Neolithic deposition of copper objects from Neuenkirchen in North-East Germany. This unique ensemble represents one of the very rare hoard finds from the early Early Neolithic, and is the first of its kind for nearly 100 years, matched only by the famous younger hoard find from Bygholm (Denmark). The beginning of neolithization at the end of the fifth millennium is not only characterised by a change in the subsistence strategy, but also by the development of far-reaching networks of the Neolithic Funnel Beaker societies in Northern Germany. Proof is provided by the first metal finds which also appear at the same time in the North and were imported from the early metallurgical centres in the Balkan-Carpathian area. The hoard of Neuenkirchen is an outstanding example for these new, long-distance contacts. Drawing from a multi-method approach, the study attempts to trace the life and journey of the individual objects in the hoard and the transformation processes they underwent before they finally ended up in the ground. To this end, an intensive typological discussion, use-wear analysis, plus trace element and lead isotopes analyses of the objects are paired with a comprehensive overview of the natural environment, deposition practices, and settlement activities in the vicinity of Neuenkirchen. In the context of comparable hoard finds from the 5th/4th millennium, and the development of early metallurgy in Southeast Europe, these results make the journey and transformation of the objects from Neuenkirchen comprehensible.

Biomarkers in Medicine is a comprehensive guide to understanding the current and future status of biomarkers. The book features 27 chapters focusing on disease biomarkers for diseases such as cancer, neurodegenerative diseases, cardiac diseases, metabolic conditions and much more.This book supplies readers with the unique insight of experts in multiple specialties in medicine and life sciences who have extensive experience in diagnostics and clinical laboratories. The book includes case studies and practical examples from different classes of biomarkers on different platforms, including new data for biomarkers in different therapeutic indications. In addition to presenting biomarker information, each chapter covers the relevant pathology and also emphasizes on preclinical and clinical manifestation of the disease process.Clinicians managing patients or clinical trials, clinical researchers, clinical laboratories, diagnostic companies, regulatory agencies, medical school graduate students, academic students, and the general public involved in healthcare delivery will all benefit from information presented in this book.

This volume includes eight chapters that describe recent updates in cancer research. Chapter One highlights the benefits of ancillary/consulting care services within pediatric oncology, including social work, psychology, neuropsychology, expressive therapies, child life, chaplaincy, teachers/school liaisons, rehabilitation therapies, nutrition, and palliative care. Chapter Two discusses various generations of chimeric antigen receptors (CAR) and recent efforts in manufacturing CAR T-cells as a therapy for cancer treatment. Chapter Three explores alternative target pathways for putative therapeutic approaches affecting chronic myeloid leukemia cells. Chapter Four reviews research done on the role of epigenetics in the initiation and progression of thyroid cancer. Chapter Five summarizes the literature that implicates the underlying molecular mechanisms of paclitaxel resistance and the potential therapeutic targets to overcome this resistance. Chapter Six deals with the inhibition of autophagy for instigating temozolomide for increasing induction of apoptosis in glioblastoma. Chapter Seven studies the use of vitamin E for leukemic stem cells reprogramming. Finally, Chapter Eight describes new molecular studies for approaches affecting chronic myeloid leukemia cells.

Diagnosis and Treatment of Spinal Cord Injury will enhance readers'understanding of the complexities of the diagnosis and management of spinal cord injuries. Featuring chapters on drug delivery, exercise, and rehabilitation, this volume discusses in detail the impact of the clinical features, diagnosis, management, and long-term prognosis of spinal cord injuries on the lives of those affected. The book has applicability for neuroscientists, neurologists, clinicians, and anyone working to better understand spinal cord injuries. - Covers both the diagnosis and treatment of spinal cord injury - Contains chapter abstracts, key facts, dictionary, and summary points to aid in understanding - Features chapters on epidemiology and pain - Includes MRI usage, biomarkers, and stem cell and gene therapy for management of spinal cord injury - Discusses pain reduction, drug delivery, and rehabilitation

Diagnosis and Treatment of Spinal Cord Injury will enhance readers'understanding of the complexities of the diagnosis and management of spinal cord injuries. Featuring chapters on drug delivery, exercise, and rehabilitation, this volume discusses in detail the impact of the clinical features, diagnosis, management, and long-term prognosis of spinal cord injuries on the lives of those affected. The book has applicability for neuroscientists, neurologists, clinicians, and anyone working to better understand spinal cord injuries. Spinal injury affects about 10 million people annually worldwide, impacting on the family unit and causing lifelong disabilities, with varied symptoms including paresthesia, spasticity, loss of motor control, and often severe pain. Cellular, Molecular, Physiological, and Behavioral Aspects of Spinal Cord Injury will enhance readers'understanding of the biological and psychological effects of spinal cord injury. Featuring chapters on gene expression, metabolic effects, and behavior, this volume discusses in detail the impact of spinal cord injury to better understand the underlying pathways and processes. The book has applicability for neuroscientists, neurologists, clinicians, and anyone working to better understand these injuries. Diagnosis and Treatment of Spinal Cord Injury: - Covers both the diagnosis and treatment of spinal cord injury - Contains chapter abstracts, key facts, dictionary, and summary points to aid in understanding - Features chapters on epidemiology and pain - Includes MRI usage, biomarkers, and stem cell and gene therapy for management of spinal cord injury - Discusses pain reduction, drug delivery, and rehabilitation Cellular, Molecular, Physiological, and Behavioral Aspects of Spinal Cord Injury: - Summarizes the neuroscience of spinal cord injury, including cellular and molecular biology - Contains chapter abstracts, key facts, dictionary, and summary points to aid in understanding - Features chapters on signaling and hormonal events - Includes plasticity and gene expression - Examines health and stress behaviors after spinal cord injury

This volume constitutes the most recent and most comprehensive consideration of the largest family of bony fishes, the Cichlidae. This book offers an integrated perspective of cichlid fishes ranging from conservation of threatened species to management of cichlids as invasive species themselves. Long-standing models of taxonomy and systematics are subjected to the most recent applications and interpretations of molecular evidence and multivariate analyses; and cichlid adaptive radiations at different scales are elucidated. The incredible diversity of endemic cichlid species in African lakes is revisited as possible examples of sympatric speciation and as serious cases for management in complex anthropogenic environments. Extreme hydrology and bathymetry as driver of micro-allopatric speciation is explored in the African riverine hotspot of diversity of the lower Congo River. Dramatic new molecular evidence draws attention to the complex taxonomy and systematics ofNeotropical cichlids including the crater lakes of Central America. Molecular genetics, genomics, imaging tools and field study techniques assess the roles of natural, sexual and kin selection in shaping cichlid traits and beyond. The complex behavioral adaptations of cichlids are considered from a number of sub-disciplines including sensory biology, neurobiology, development, and evolutionary ecology. Most importantly, this volume puts forth a wealth of new interpretations, explanatory hypotheses and proposals for practical management and applications that will shape the future for these remarkable fishes in nature as well as their use as models for the study of biology.

Now in its third edition, the Oxford Textbook of Endocrinology and Diabetes is an up-to-date, objective and comprehensive text that covers the full scope of endocrinology and diabetes. It contains wide ranging and pragmatic advice on diagnosis and clear guidelines for recommended management, while also covering the scientific principles that underlie the medical practice in this important field. The book has been re-organised into 15 overarching sections, with new sections on Endocrinology of Pregnancy and Management of the Transgender Patient included. All other sections have been extensively updated and restructured. Each chapter is written by an internationally acknowledged expert, relates basic science to evidence based guidelines and clinical management, and where appropriate offers an outline of the controversies in the subject. The textbook has an international focus and deals with subject matter applicable across the globe. The new edition has over 800 images complementing the extensive text and information provided. The book is a'one-stop'text for trainees and consultants in Endocrinology and Diabetes, residents, those preparing for sub-specialty exams and other professionals allied to the area who need to gain an understanding of the field. It acts as both a point of reference for the experienced consultant as well as a trusted training resource. Purchase of the print work also includes full access to the online edition of the textbook for the life of the edition.

The book is based on results from the Russian expedition in the region of the Antarctic Peninsula and Powell Basin in the northern part of the Weddell Sea, as well as on the review of earlier research in the region. The main goal of the research was to collect the newest data and study the physical properties and ecology of this key region of the Southern Ocean. Data analysis is supplemented with numerical modeling of the atmosphere-ocean interaction and circulation in the adjacent region, including research on rogue waves. The focus of the study was the Antarctic Circumpolar Current, currents and water properties in the Bransfield Strait and Antarctic Sound, properties of seawater, currents, ecosystem and biological communities in the Powell Basin of the northwestern Weddell Sea, and their variations. An attempt is made to reveal the role of various components of the Antarctic environment in the formation of biological productivity and maintenance of the Antarctic krill population. This is especially important as in the last decades the Antarctic environment has experienced significant changes related to the global climatic trends.

Monografia jest rezultatem dociekań autorki na temat instytucji powołanej przez Ministerstwo Kultury i Sztuki (1949) do realizacji interdyscyplinarnych badań nad genezą i funkcjonowaniem państwa pierwszych Piastów, które podjęto w związku z jubileuszem Tysiąclecia Państwa Polskiego i jego chrztu (1966). Akcja „przygotowania wielkiej rocznicy”, choć inaczej tę rocznicę rozumiał Kościół, inaczej państwo, a jej cele naukowe splatały się z politycznymi, zaowocowała autentycznym przełomem w stanie wiedzy o początkach polskiej państwowości, społeczeństwa i Kościoła, na lata kształtując postrzeganie „pradziejów” państwa Piastów. Odegrała również ważną rolę w kreowaniu nowej świadomości narodowej społeczeństwa polskiego po zmianie granic w 1945 roku.

Cancer is a complex and heterogeneous (systematic) disease that exhibits high levels of robustness against various therapeutic interventions. Due to the complex, heterogeneous, and evolving nature of cancer, it is essential for a system-oriented view to be adopted in order to understand the pathogenic mechanism of cancer which will eventually lead to the drug discovery and treatment of patients. This book not only provides new insights from system modeling and large scale experimental data, but also will allow the reader to perceive the systematic characteristics of cancer under some micro-environments. Based on the systems biology method and genome-wide high throughput data, the book presents the PPI network, gene regulatory network and epigenetic network as an integrated genetic and epigenetic cellular network of lung cancer, bladder cancer, thyroid cancer, colorectal cancer, and liver cancer to investigate their core signaling pathways of the carcinogenesis process to identify their corresponding significant carcinogenic biomarkers as drug targets for systems drug discovery and design. Consequently, the book presents the design of a multiple-molecule drug that can target these biomarkers for the therapeutic treatment of cancer with fewer side effects.

Pulmonary vascular disorders are a complex and fascinating group of diseases. The aim of this book is to exhaustively review the genetics, physiology, diagnosis, management, and treatment of pulmonary vascular disorders with the purpose of helping general physicians and specialists in internal medicine, cardiology, pneumology, immunology, rheumatology, and hematology to identify and assess patients with vascular pulmonary disorders. Special emphasis has been placed upon pulmonary hypertension, pulmonary fibrosis, and pulmonary embolism as well as on pulmonary vascular involvement in immune-mediated diseases, chronic obstructive and advanced pulmonary disease, and sleep apnea. Additional topics that are covered in this book include pulmonary vascular injury occurring in alpha-1 antitrypsin deficiency, congenital heart disease and pregnancy. The text is supported by figures and tables to help the reader understand mechanisms of pulmonary vascular disorders in different clinical settings.

The system of the Tigris-Euphrates Rivers is one of the great river systems of southwestern Asia. It comprises the Tigris and Euphrates Rivers, which follow roughly parallel courses through the heart of the Middle East. The lower portion of the region that they run through is known as Mesopotamia, was one of the cradles of civilisation. There are several environmental factors that govern the nature of the two rivers and shape the landscape the two rivers running through. Geological events create rivers, climate monitor the water supply, the surrounding land influences the vegetation and the physical and chemical features of water. The Tigris-Euphrates system runs through the territory of four countries, Iraq, Iran, Turkey and Syria. Therefore, any scientific approach to the environment of these two rivers should include the natural history events in these countries. The book'Tigris and Euphrates Rivers: Their Environment from Headwaters to Mouth'will be divided into nine parts. These parts deal with the issues of the environment, the status of the flora and fauna, the abiotic aspects, ecology, hydrological regime of the two rivers, the biotic aspects. Water resources, stress of the environment, conservation issues. Since the book of Julian Rzoska'Euphrates and Tigris Mesopotamian Ecology and Destiny'in 1980, no book or major reference has been published that includes between its cover the facts and information that the present book will present. Therefore, the importance of the present book falls in stating the present status of the environment of the two rivers and the comparison of their environment between now and that of 37 years ago as given by J. Rzoska (1980). The recent studies showed that there are a large number of natural and political events that happened within the last three decades in the area of the Tigris-Euphrates river system that for sure have done a great change to the environmentof the two rivers and consequently changing the biological and non-biological resources of the two rivers. This book will be a reference book to both Academic and students across the Middle East in different disciplines of knowledge to use in their researches on Tigris-Euphrates river system. The scholars interested in this area will use this book as a guide to compare this freshwater system with other areas in Asia and the world.

The importance of molecular approaches for comparative biology and the rapid development of new molecular tools is unprecedented. The extraordinary molecular progress belies the need for understanding the development and basic biology of whole organisms. Vigorous international efforts to train the next-generation of experimental biologists must combine both levels – next generation molecular approaches and traditional organismal biology. This book provides cutting-edge chapters regarding the growing list of marine model organisms. Access to and practical advice on these model organisms have become a conditio sine qua non for a modern education of advanced undergraduate students, graduate students and postdocs working on marine model systems. Model organisms are not only tools they are also bridges between fields – from behavior, development and physiology to functional genomics. Key Features Offers deep insights into cutting-edge model system science Provides in-depth overviews of all prominent marine model organisms Illustrates challenging experimental approaches to model system research Serves as a reference book also for next-generation functional genomics applications Fills an urgent need for students Related TitlesJarret, R. L. & K. McCluskey, eds. The Biological Resources of Model Organisms (ISBN 978-1-1382-9461-5)Kim, S.-K. Healthcare Using Marine Organisms (ISBN 978-1-1382-9538-4)Mudher, A. & T. Newman, eds. Drosophila: A Toolbox for the Study of Neurodegenerative Disease (ISBN 978-0-4154-1185-1)Green, S. L. The Laboratory Xenopus sp. (ISBN 978-1-4200-9109-0)

Recent Advances in Freshwater Crustacean Biodiversity and Conservation focuses on minor crustacean groups and regionally endemic groups, all from freshwaters. Chapters in this book cover crustaceans such as Maxillopods, Mysids, Cumaceans, Isopods, Amphipods, Branchiopods, Copepods, and Decapods. Each looks at global or regional fauna and discusses conservation issues for that group. The majority of the chapters are based on papers presented at symposia organized by the editors at two international scientific meetings held in Barcelona and Washington DC. The contributors are world-renowned experts on their groups, as well as on freshwater crustacean conservation and biodiversity at global levels. It has previously been difficult for conservation managers, NGOs, and university professors and students who may not have access to comprehensive journal subscriptions to find relevant information on diversity and conservation of freshwater crustaceans. This book meets that need, addressing crustacean groups not previously treated and providing additional information beyond any presented in existing books. As the editors write in their introduction: we cannot conserve and we cannot protect what we do not know exists.This is a reliable, cutting-edge reference for anybody involved in crustacean research: students, researchers, agencies, and NGOs, as well as science educators, conservationists, and government conservation policymakers. The book will also be useful for those working in aquaculture and fisheries, given that many of the taxa discussed are economically important.

Cytogenomics demonstrates that chromosomes are crucial in understanding the human genome and that new high-throughput approaches are central to advancing cytogenetics in the 21st century. After an introduction to (molecular) cytogenetics, being the basic of all cytogenomic research, this book highlights the strengths and newfound advantages of cytogenomic research methods and technologies, enabling researchers to jump-start their own projects and more effectively gather and interpret chromosomal data. Methods discussed include banding and molecular cytogenetics, molecular combing, molecular karyotyping, next-generation sequencing, epigenetic study approaches, optical mapping/karyomapping, and CRISPR-cas9 applications for cytogenomics. The book's second half demonstrates recent applications of cytogenomic techniques, such as characterizing 3D chromosome structure across different tissue types and insights into multilayer organization of chromosomes, role of repetitive elements and noncoding RNAs in human genome, studies in topologically associated domains, interchromosomal interactions, and chromoanagenesis. This book is an important reference source for researchers, students, basic and translational scientists, and clinicians in the areas of human genetics, genomics, reproductive medicine, gynecology, obstetrics, internal medicine, oncology, bioinformatics, medical genetics, and prenatal testing, as well as genetic counselors, clinical laboratory geneticists, bioethicists, and fertility specialists. - Offers applied approaches empowering a new generation of cytogenomic research using a balanced combination of classical and advanced technologies - Provides a framework for interpreting chromosome structure and how this affects the functioning of the genome in health and disease - Features chapter contributions from international leaders in the field

This two-volume edited book highlights and reviews the potential of the fossil record to calibrate the origin and evolution of parasitism, and the techniques to understand the development of parasite-host associations and their relationships with environmental and ecological changes. The book deploys a broad and comprehensive approach, aimed at understanding the origins and developments of various parasite groups, in order to provide a wider evolutionary picture of parasitism as part of biodiversity. This is in contrast to most contributions by parasitologists in the literature that focus on circular lines of evidence, such as extrapolating from current host associations or distributions, to estimate constraints on the timing of the origin and evolution of various parasite groups. This approach is narrow and fails to provide the wider evolutionary picture of parasitism on, and as part of, biodiversity. Volume one focuses on identifying parasitism in the fossil record, and sheds light on the distribution and ecological importance of parasite-host interactions over time. In order to better understand the evolutionary history of parasites and their relationship with changes in the environment, emphasis is given to viruses, bacteria, protists and multicellular eukaryotes as parasites. Particular attention is given to fungi and metazoans such as bivalves, cnidarians, crustaceans, gastropods, helminths, insects, mites and ticks as parasites. Researchers, specifically evolutionary (paleo)biologists and parasitologists, interested in the evolutionary history of parasite-host interactions as well as students studying parasitism will find this book appealing.

Chemoinformatics and Bioinformatics in the Pharmaceutical Sciences brings together two very important fields in pharmaceutical sciences that have been mostly seen as diverging from each other: chemoinformatics and bioinformatics. As developing drugs is an expensive and lengthy process, technology can improve the cost, efficiency and speed at which new drugs can be discovered and tested. This book presents some of the growing advancements of technology in the field of drug development and how the computational approaches explained here can reduce the financial and experimental burden of the drug discovery process. This book will be useful to pharmaceutical science researchers and students who need basic knowledge of computational techniques relevant to their projects. Bioscientists, bioinformaticians, computational scientists, and other stakeholders from industry and academia will also find this book helpful. - Provides practical information on how to choose and use appropriate computational tools - Presents the wide, intersecting fields of chemo-bio-informatics in an easily-accessible format - Explores the fundamentals of the emerging field of chemoinformatics and bioinformatics