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Colorectal Cancer Treatment Resistance: Mechanisms, Insights, Advances and Solutions provide insights, knowledge, and potential solutions for healthcare professionals, researchers, and individuals affected by colorectal cancer. The book discusses innovative therapies, personalized medicine, and the latest scientific advancements in the field, all aimed at enhancing the effectiveness of treatment and improving the prognosis for colorectal cancer patients. It elucidates on the broader context of cancer research and treatment strategies that have the potential to impact the overall approach to managing colorectal cancer and, by extension, other types of cancer that may exhibit similar resistance challenges.By studying and addressing resistance mechanisms, researchers and healthcare professionals can work towards improving patient outcomes and the overall quality of cancer care. - Focuses on the challenges and strategies associated with overcoming treatment resistance in colorectal cancer - Explores the various factors contributing to treatment resistance, such as genetic mutations, tumor heterogeneity, and the tumor microenvironment - Discusses the different treatment modalities and approaches used in colorectal cancer therapy and how they can be adapted to overcome resistance

This book addresses the pressing problem of drug resistance in the treatment of breast cancer. It provides a comprehensive understanding of the complex mechanisms underlying drug resistance and presents the latest advances in therapeutic approaches to overcome this enormous challenge. The book begins with an introduction to the biology of breast cancer, treatment modalities and the mechanisms of drug resistance. This includes the principles of drug resistance in targeted, immune-, endocrine and chemotherapy. In the following sections, the authors present innovative strategies to overcome drug resistance and new research directions, among others the role of the microbiome in drug resistance, molecular profiling of patients for personalized medical care, and new drug delivery systems. Finally, the book concludes with a discussion of the differences in the prevalence and treatment success of breast cancer between high- and low-income countries. This book is an informative resource for students, researchers, and clinicians in the field of breast cancer research and oncology in general.

Pathophysiological Aspects of Proteases in Cancer provides a comprehensive overview of the multifaceted field of proteases in the cellular environment and focuses on the recently elucidated functions of complex proteolytic systems in physiology and pathophysiology. The book both gives insights on the general aspects of the role of proteases in cancer, their role as diagnostics and prognostics biomarkers, their impact on chemoresistance, and the future cutting-edge technologies like cocktail therapies and Cyber Knife technology. Given the breadth and depth of information covered in the respective contributions, the book will be immensely useful for researchers in oncology and working to identify targets for drug development.Multidisciplinary in scope, the book bridges the gap between fundamental and translational research, with applications in the biomedical and pharmaceutical industry, making it a thought-provoking read for basic and applied scientists engaged in biomedical research. - Gives insight into the spectrum of proteases, protease inhibitors, and protease interactors involved at the cellular and molecular level in cancer development - Gives a comprehensive overview of the role of proteases in modulating cellular metabolism and chemoresistance to better understand how proteases play in early to the end point in cancer development and metastasis - Provides a multidisciplinary approach demonstrating the biochemical and signal transduction mechanisms associated with dysregulation of proteases, leading to the manifestation of various diseases - Highlights the roles and regulation of different types of proteases, as well as their synthetic and endogenous inhibitors - Bridges the gap between fundamental and translational research, with applications in the biomedical and pharmaceutical industry

β-Carbolines: A Privileged Scaffold for Modern Drug Discovery provides a summary of methods for the synthesis of various natural products engineered with the diverse β-carboline scaffold and their biological evaluation.β-carboline and its derivatives have generated considerable interest in recent years for their versatile properties in chemistry and pharmacology. This is due to their ability to act as agonists to benzodiazepine receptors, hydroxy serotonin receptors, and intercalate into DNA, to inhibit CDK, Topisomerase, and monoamine oxidase enzymes. Their pharmacological properties include anxiolytic, hypnotic, anticonvulsant, antiviral, antiparasitic and antimicrobial attributes. This book provides a summary of methods for the synthesis of various natural products engineered with the diverse β-carboline scaffold and their biological evaluation.Features: Focuses on the different application and therapies of β-carbolines. Provides a summary of methods for the synthesis of various natural products engineered with the diverse β-carbolines. Discusses methods of biological evaluation of β-carbolines. Explores different chemical transformations occurring with synthesis using β-carbolines. Covers both heterocyclic synthesis and multicomponent synthesis related to β-carbolines. It will be key reading for researchers in medicinal chemistry and drug discovery looking to understand the broad potential of β-carbolines.

This volume covers recent developments on the role, composition, and functional significance of intercellular and interorganellar transfer. It highlights the involvement of intercellular and interorganellar transfer in cell and developmental biology, differentiation, pathogen dissemination, shaping the genetic makeup of organisms, and the development of various diseases. Animals and plants evolved different communication mechanisms and transfer of molecules and organelles between cells and between organelles within the individual cells. Tunneling nanotubes (TNTs) in animals, discovered as recently as 2004, and their functional equivalent in plants, plasmodesmata, discovered over 100 years ago, are the membranous bridges that mediate the transfer of organelles, membrane patches, vesicles, DNA/RNA, and different molecules between cells. In addition, there are other means of transfer and communication between the cells, such as cytonemes, airinames, extracellular vesicles (exosomes), and others. Variations in cytoskeletal composition, morphology, modality, and connected cells suggest that these structures play a role in development, establishment of cell fate, progenitor cell differentiation, cell reprogramming, ferroptosis, generation of cancer stem cells, and various diseases. The exchange of intact membrane patches (trogocytosis) between cells of the immune system may modify the immune response. Additionally, the transfer of genetic information between nucleus and organelles and cells of different species can shape the species and evolutionary outcome. Viral and bacterial pathogens can hijack the inter-cellular transfer routes to spread more efficiently. Cell-to-cell transfer of animal and plant pathogens can also occur by the virological synapse (VS). These specialized pathogen-induced structures share similarities and differences with neurological and immunological synapses.

This new book takes an in-depth look at the emerging and prospective field of computational biology and bioinformatics, which possesses the ability to analyze large accumulated biological data collected from sequence analysis of proteins and genes and cell population with an aim to make new predictions pertaining to drug discovery and new biology. The book explains the basic methodology associated with a bioinformatics and computational approach in drug designing. It then goes on to cover the implementation of computational programming, bioinformatics, pharmacophore modeling, biotechnological techniques, and pharmaceutical chemistry in designing drugs. The major advantage of intervention of computer language or programming is to cut down the number of steps and costs in the field of drug designing, reducing the repeating steps and saving time in screening the potent component for drug or vaccine designing.The book describes algorithms used for drug designing and the use of machine learning and AI in drug delivery and disease diagnosis, which are valuable in clinical decision-making. The implementation of robotics in different diseases like stroke, cancer, COVID-19, etc. is also addressed. Topics include machine learning, AI, databases in drug design, molecular docking, bioinformatics tools, target-based drug design, and immunoinformatics, chemoinformatics, and nanoinformatics in drug design. Drug repurposing in drug design in general as well as for specific diseases, including cancer, Alzheimer's disease, tuberculosis, COVID-19, etc., is also addressed in depth.

Phylogenomics: Foundations, Methods, and Pathogen Analysis offers a deep overview of phylogenomics as a field, compelling recent developments, and detailed methods and approaches for conducting new research. Early chapters introduce phylogenomic taxonomies of organisms and pathogens, phylogenomic networks, phylogenomics of virus virulence, and ancient DNA analysis, with a second section offering methods, detailed descriptions and step-by-step instruction in genome assembly and annotation, horizontal gene transfer studies, Bayesian evaluation, phylogenetic tree building, microbial evolution modeling, and molecular epidemiology. The book's final section offers various examples of phylogenomic analysis across medically significant bacteria and viruses, including Yersinia pestis, Salmonella, Shigella, Vibrio cholera, and Mycobacterium tuberculosis, amongst others. - Offers a full overview of phylogenetics and phylogenomics, from its foundations to methods and specialized case studies - Presents methodologies and algorithms for phylogenomic research studies and analyzes medically significant microorganisms - Considers examples of phylogenomic analysis across a range of medically significant pathogens - Includes chapter contributions from leading international experts

This book is an illuminating publication that explores the cutting-edge research and potential of natural compounds in the fight against cancer. This book provides a comprehensive and accessible overview of the diverse range of nature-based compounds derived from plants, marine organisms, fungi, and other sources, which have shown promising anti-cancer properties. Cancer remains one of the most challenging health issues worldwide, and the search for innovative and effective treatments continues. This book delves into the historical use of natural compounds in traditional medicine, highlighting their evolution into modern cancer research. With a focus on molecular mechanisms, the book reveals how these natural compounds combat cancer cells, induce apoptosis, and inhibit tumor angiogenesis, among other critical processes. Bringing together the latest research and advancements, this publication showcases preclinical studies demonstrating the efficacy of natural compounds in cell and animal models. Furthermore, it presents insights from clinical trials investigating the safety and potential benefits of natural compounds in cancer patients, thus bridging the gap between lab findings and real-world applications. Readers of all backgrounds, from researchers to healthcare professionals, will appreciate the valuable content presented in this book. The book discusses the advantages of natural compounds over traditional cancer treatments and addresses challenges in their development, including standardization and regulatory aspects. One of the book's key strengths lies in its exploration of integrative approaches, where natural compounds are combined with existing cancer therapies, offering a potential avenue for enhanced treatment outcomes and reduced side effects. With its wide-ranging scope, this book aims to serve as an essential resource for the academic community, healthcare practitioners, and students in oncology-related disciplines. Whether you seek a deeper understanding of molecular intricacies or new approaches to incorporate into clinical practice, this publication offers valuable insights and inspiration. As we forge ahead in the battle against cancer, this book stands as a beacon of hope, highlighting the immense potential of nature's offerings in our pursuit of effective cancer treatments as well as preventive strategies against cancer.

Deep Learning in Genetics and Genomics vol. 1, Foundations and Applications, the intersection of deep learning and genetics opens up new avenues for advancing our understanding of the genetic code, gene regulation, and the broader genomics landscape. The book not only covers the most up-to-date advancements in the field of deep learning in genetics and genomics, but also a wide spectrum of (sub) topics including medical and clinical genetics, predictive medicine, transcriptomic, and gene expression studies. In 21 chapters Deep Learning in Genetics and Genomics vol. 1, Foundations and Applications describes how AI and DL have become increasingly useful in genetics and genomics research where both play a crucial role by accelerating research, improving the understanding of the human genome, and enabling personalized healthcare. From the fundamentals concepts and practical applications of deep learning algorithms to a wide range of challenging problems from genetics and genomics, Deep Learning in Genetics and Genomics vol. 1, Foundations and Applications creates a better knowledge of the biological and genetics mechanisms behind disease illnesses and improves the forecasting abilities using the different methodologies described. This title offers a unique resource for wider, deeper, and in-depth coverage of recent advancement in deep learning-based approaches in genetics and genomics, helping researchers process and interpret vast amounts of genetic data, identify patterns, and make discoveries that would be challenging or impossible using traditional methods. - Brings together fundamental concepts of genetics, genomics, and deep learning - Includes how to build background of solution methodologies and design of mathematical and logical algorithms - Delves into the intersection of deep learning and genetics, offering a comprehensive exploration of how deep learning techniques can be applied to various aspects of genomics

Encyclopedia of Quaternary Science, Third Edition, Six Volume Set brings together the multidisciplinary expertise needed to understand the history of humans, life, environmental, and climate change to understand what we may expect over the coming decades. Since publication of the previous edition, our understanding of many topics has been revolutionized by new discoveries and new techniques. The development of ancient DNA studies, for example, has revolutionized our thinking about the origins, dispersal, and population dynamics of our ancestors. Every new aDNA analysis from ancient human remains causes the story to become more complex.We are the sole survivors of the genus Homo, yet we harbor genetic fragments from other closely related but long-extinct lineages. The Quaternary is uniquely situated as a laboratory in which to study the shaping of the modern world, including biotic responses to large-scale environmental change. This new edition of this book is the most comprehensive account of state-of-the-art research in this field. - Revised and expanded, this new edition brings the science up-to-date by featuring advances in all the multi-disciplinary aspects of Quaternary science - Focuses new content on numerical modeling for paleoclimate and ice-sheet reconstructions, which have greatly advanced since publication of the Second Edition - Covers ancient DNA, which has revolutionized our knowledge of human origins and dispersals, plant and animal population genetics, and more - Includes short, structured chapters, which help readers finding the information they need and save time

African Plant-Based Products as a Source of Potent Drugs to Overcome Cancers and their Chemoresistance: Part Two: Potent Botanicals to Overcome Cancers and their Chemoresistance offers detailed information on the best African medicinal plants that could be useful for the development of efficient herbal drugs, as well as the best phytochemicals that could be explored as potential pharmaceuticals to efficiently overcome cancers and their drug resistance. The book identifies and comments on the best cytotoxic African medicinal plants. The book also provides knowledge on ethnomedicinal uses of the identified plants, their pharmacological potency, and their phytochemistry.An overview of the relationship between cancer and other human diseases healed in the traditional health system with the plants documented is also highlighted. The book appears a unique tool for Scientists to have state-of-the-art of the best cytotoxic plants from the African flora. - Provides a unique tool compiling the best of African plants with amazing potential toward various cancer cell lines, including the multidrug-resistant phenotypes - Discusses in highlights the geographic distribution of the best cytotoxic African plants - Compiles the ethnomedicinal, pharmacological, and phytochemistry information of the best antiproliferative African plants

Genetics and Evolution of Infectious Diseases, Third Edition discusses the evolving field of infectious diseases and their continued impact on the health of populations, especially in resource-limited areas of the world where they must confront the dual burden of death and disability due to infectious and chronic illnesses. Although substantial gains have been made in public health interventions for the treatment, prevention, and control of infectious diseases, in recent decades the world has witnessed the emergence of the human immunodeficiency virus (HIV) and the COVID-19 pandemic, increasing antimicrobial resistance, and the emergence of many new bacterial, fungal, parasitic, and viral pathogens. Fully updated and revised, this new edition presents the consequences of such diseases, the evolution of infectious diseases, the genetics of host-pathogen relationship, and the control and prevention strategies that are, or can be, developed. This book offers valuable information to biomedical researchers, clinicians, public health practitioners, decisions-makers, and students and postgraduates studying infectious diseases, microbiology, medicine, and public health that is relevant to the control and prevention of neglected and emerging worldwide diseases. - Takes an integrated approach to infectious diseases - Provides the latest developments in the field of infectious diseases - Focuses on the contribution of evolutionary and genomic studies for the study and control of transmissible diseases - Includes updated and revised contributions from leading authorities, along with six new chapters

This book comprehensively reviews the recent advancements in apoptosis research and evaluates its therapeutic targets and strategies in controlling various human diseases. The initial chapter presents the molecular components that regulate apoptosis and its importance for pathogenic processes. The subsequent chapters discuss the molecular mechanisms and signaling pathways involved in apoptosis induction and inhibition. The book also examines the role of mitochondria-driven apoptosis and therapeutic strategies for targeting mitochondria-mediated cell death. Further, the book discusses the role of apoptosis in different diseases, including neurodegeneration, cancer, diabetes, cardiovascular diseases, parasitic infections, autoimmune diseases, reproductive disorders, and infertility. Towards the end, the book outlines the recent advances in the field of apoptosis-based therapies and explores some highlights of a very active field of drug development. This book is useful for the researchers involved in designing and developing new drugs and drug targets for the treatment of different human diseases.

There are different types of treatment for breast cancer, including surgery, chemotherapy, radiotherapy, hormone therapy, immunotherapy, and targeted therapy. Deciding on the types of treatment depends on several factors, such as the stage and grade of cancer, biomarkers, and general health of patients. The seventh volume of the “Interdisciplinary Cancer Research” series, entitled “Breast Cancer Treatment: An Interdisciplinary Approach” publishes comprehensive reviews on different treatment opportunities on breast cancer. An update on treatment of triple-negative breast cancer and ductal carcinoma in situ is provided. Ablative breast cancer surgery, radiotherapy, and percutaneous breast cancer treatment are explained. Promising hormone immunotherapy combination as well as targeted therapies for breast cancer is also discussed. This interdisciplinary series is of special value to researchers working on oncology. This is the main concept of Cancer Immunology Project (CIP), which is a part of Universal Scientific Education and Research Network (USERN). This interdisciplinary book will be of special value to researchers and oncologists who wish to extend their knowledge on breast cancer treatment.

Lung cancer is one of the most common cancers and the leading cause of deaths worldwide. The eighth volume of the “Interdisciplinary Cancer Research” series, entitled “Lung Cancer Pathophysiology: An Interdisciplinary Approach” publishes comprehensive reviews on the mechanisms of lung cancer. Fundamental elements of a lung cancer multidisciplinary team are discussed. The epithelial to mesenchymal transition in lung cancer, and the roles of tumor immune microenvironment, NK cells, RNA, micro-RNA, and long-non coding RNA in lung cancer are explained. A comprehensive genomic profiling in lung cancer in the era of immunotherapy approaches is also provided in this volume. This interdisciplinary series is of special value to researchers working on oncology. This is the main concept of Cancer Immunology Project (CIP), which is a part of Universal Scientific Education and Research Network (USERN). This interdisciplinary book will be of special value to researchers, oncologists, and oncosurgeons who wish to extend their knowledge on lung cancer.

This book presents an overview of the rapidly developing field of nanotechnology applications in drug delivery systems and covers a variety of technologies and materials that help in achieving vast variation in the particle size needed in technology and drug delivery-based research. It discusses nanotechnology's use in healthcare for the development of target-specific drug therapy and smart field systems and in the pharmaceutical industry to improve the quality, efficacy, and shelf life of medicines. Bringing together principles, theory, practice, and applications of nanotechnology, the book is a useful resource for chemists, physicists, biomedical researchers, engineers, advanced undergraduate and graduate-level students in nanotechnology, researchers in pharmaceutical sciences, chemistry, biology, biotechnology engineering, and general readers in nanotechnology.

Functionalized Nanomaterials for Cancer Research: Applications in Treatments, Tools and Devices presents an in-depth and step by step description of knowledge on functionalized nanomaterials for cancer research, including treatment and future developments as well as their impact on patients'overall outcomes. The book discusses the functionalized nanoplatforms for cancer detection and imaging, interactions between nanomaterials and cancer cells, and drug resistant malignancies. The chapters are organized in a manner that can be readily adopted as sources for new and further studies by highlighting the main in vitro and in vivo nano-therapeutic achievements on cancer. Additionally, current trends on functionalized nanomaterials for cancer research and commercial scale opportunities are discussed. It is a valuable resource for researchers, oncologists, students, and members of the biomedical and medical fields who want to learn more about the potential of nanotechnology in cancer research and treatment. - Provides comprehensive coverage on functionalized nanomaterials for cancer therapeutics and future developments - Explores current trends on functionalized nanomaterials for cancer research and commercial scale opportunities - Discusses real-world case studies on functionalized nanomaterials for cancer therapy and research

Personalized Epigenetics, Second Edition discusses the core translatability of epigenetics to health management of individuals who have unique variations in their epigenetic signatures that can guide both disorder and disease prevention and therapy. Fully updated and revised, this new edition details inter-individual variability in the major epigenetic process in humans consisting of DNA methylation, histone modifications, noncoding RNA, and the diagnostic, prognostic, and therapeutic potential of the field. It also reviews the impact of the environment on epigenetic variations among individuals and the role of pharmacology and drug development in personalized epigenetics. Most importantly, the text covers personalized epigenetics from a disease-oriented perspective, presenting chapters that provide advances in widespread disorders or diseases, including diabetes, cancer, autoimmune disorders, obesity, cardiovascular diseases, neurological disorders, and pain management. - Includes new chapters on topics such as the limitations of personalized epigenetic variation comparisons; personalized epigenetics technologies; epigenetics of personalized nanomedicine; personalized epigenetic management of diabetes; epigenetics and chemoresistance; and personalized epigenetics and neurological disorders - Covers key methodological processes that are important in personalized medicine - Offers disease research case studies to provide in-depth discussion of examples of recent epigenetic research on a disease area - Features topics such as forensic epigenetics, epigenetics of personalized toxicity, limitations of epigenetic variation comparisons, and nanomedicine and nutrigenomics as applied to personalized epigenetics

Comprehensive Precision Medicine holistically integrates essential and interconnecting disciplines that contribute to the make-up of Precision Medicine as we know it today. Encompassing almost 90 contributions from eminent scholars and professionals, the book's contents are organized across 3 volumes and 7 major subject areas, each representing a key pillar driving the evolution and progression of healthcare delivery. Precision medicine approaches will transform the training and practice of all aspects of professional healthcare delivery, including medicine, nursing, pharmacy, psychology, rehabilitation, and social work. This will be a fundamental reference resource for students, post-graduate trainees, researchers, scientists and clinicians interested in precision medicine. Additionally, this resource will be of interest to regulators, policy makers, and public health practitioners across the globe. - Provides comprehensive coverage and is basically a'one-stop'resource across all disciplines contributing to precision medicine - Authoritative guide edited by distinguished authorities who are shaping the advancement of precision medicine - Thematically organized, allowing for easy exploration across interconnecting disciplines - Digitally innovative resource with multimedia features that complement the text and provide additional learning and teaching resources

The second edition of this book presents the role of osmolytes in human health and diseases. Some of the chapters deal about the possibility of the use of osmolytes as diagnostic biomarkers and potential drug design for neurodegenerative and other human diseases. Other chapters also include reviews on the role of osmolytes in cancer, metastasis, infectious diseases, metabolic disorders, immunological disorders, and tissue regeneration. Importantly, the book also contain recent updates on the role of naturally occurring osmolytes in protein folding pathway, protein stability, and their underlying mechanisms. The book also covers the aspects that osmolytes could promote conformational alterations of transcription factors that favor metastatic behavior. Potential of the osmolytes in the various process of vaccine development, including enhancing the efficacy, production, and purification steps are also succintly described. Towards the end, the book also elucidates the use of specific molecules for the prevention of toxic gain of functions and restoration of function to disease-causing mutant protein. This book is an invaluable asset for the researchers especially working in osmolyte biology and scientists involved in basic and clinical research particularly neurodegeneration, diabetes, cancer, and metabolic disorders.

The “Lung Cancer Diagnosis and Treatment: An Interdisciplinary Approach” is the ninth volume of the “Interdisciplinary Cancer Research” series, publishes comprehensive reviews on the diagnosis and treatment of lung cancer. Application of artificial intelligence in lung cancer detection is explained well. Recent advances in the treatment of lung cancer is presented in this volume, while opportunities and challenges in immunotherapy are discussed. This interdisciplinary series is of special value to researchers working on oncology. This is the main concept of Cancer Immunology Project (CIP), which is a part of Universal Scientific Education and Research Network (USERN). This interdisciplinary book will be of special value to researchers, oncologists, and oncosurgeons who wish to extend their knowledge on lung cancer.

This book tries to emphasize the mechanisms associated with the resistance towards various anti-cancer therapies The focus has been given to the role of cancer stem cells, immune cells, and the multiway impact of tumor microenvironment in drug resistance. The book delves into the role of epigenetic alterations, autophagy, intracellular compartments, and the impact of gut microbiome on therapeutic resistance. Each chapter of the book has elaborated on these aspects that are exclusively or mutually driving the therapeutic non-responsiveness towards various current clinical candidates. In addition to that the book has also discussed novel strategies to overcome the therapeutic challenge by employing combinatorial therapies that can prove to be useful and effective. Overall the book reflects on the current treatment challenges, futuristic strategies and new research initiatives that explore novel treatment options.

In the evolving environment of bioinformatics, genomics, and computational biology, academic scholars are facing a challenging challenge – keeping informed about the latest research trends and findings. With unprecedented advancements in sequencing technologies, computational algorithms, and machine learning, these fields have become indispensable tools for drug discovery, disease research, genome sequencing, and more. As scholars strive to decode the language of DNA, predict protein structures, and navigate the complexities of biological data analysis, the need for a comprehensive and up-to-date resource becomes paramount. The Research Anthology on Bioinformatics, Genomics, and Computational Biology is a collection of a carefully curated selection of chapters that serves as the solution to the pressing challenge of keeping pace with the dynamic advancements in these critical disciplines. This anthology is designed to address the informational gap by providing scholars with a consolidated and authoritative source that sheds light on critical issues, innovative theories, and transformative developments in the field. It acts as a single reference point, offering insights into conceptual, methodological, technical, and managerial issues while also providing a glimpse into emerging trends and future opportunities. Within the anthology, scholars will find a wealth of knowledge spanning diverse topics, from gene selection using metaheuristics to the application of deep learning in biological big data analysis. It delves into cancer classification methodologies, cluster analysis with big data applications, and the impact of digitalization, robotics, and genomic research in livestock development. The book also explores precision drug screening for cystic fibrosis patients, presents a hybrid high-performance computing algorithm for gene regulatory network construction, and discusses the collaborative efforts between librarians and bioinformatics communities. The Research Anthology on Bioinformatics, Genomics, and Computational Biology offers the comprehensive solution needed to face the challenges presented to academic scholars. By providing a consolidated, authoritative, and up-to-date reference that empowers researchers, scientists, educators, and professionals to navigate and contribute to the forefront of transformative research in biological data analysis, this anthology provides a gateway to understanding and advancing the pivotal disciplines shaping the future of life sciences.

Anthropogenic climate change is the defining environmental challenge of this century, posing an existential threat not only to humans but also to the vast array of plants and animals that inhabit our planet. Among these, insects reign as the largest and most diverse group of organisms, playing critical roles in nutrient cycling, pollination, seed dispersal, and population control of other species. Additionally, they serve as a vital food source for various taxa and act as vectors for numerous human diseases. This comprehensive but accessible text delves into the intricate world of these remarkable creatures, with a focus extending beyond economically or medically significant species to encompass non-model organisms. In so doing, it uncovers valuable insights into the implications posed by climate change on global insect populations. The book reviews the conceptual approaches and most significant advances in our current understanding of insect physiology, genetics, ecology, evolution, and conservation within the ongoing and rapidly developing context of global anthropogenic climate change. In addition to presenting historical information about climate change effects on insects, it synthesizes the available knowledge concerning the impact of climate change on insect populations, communities, and ecosystem processes. Furthermore, it identifies the most relevant topics and promising methodological approaches for further research in this crucial field. Effects of Climate Change on Insects has been written to engage a diverse audience, catering to the curiosity of both students and researchers seeking knowledge on the critical subject of insect responses to climate change. As the field continues to grow in importance, it will be an indispensable resource for anyone seeking to comprehend the intricate interplay between these fascinating creatures and our ever-changing world.

Discover the fascinating world of mitophagy and its profound implications in aging, diseases, and therapeutic interventions. In this book a team of leading experts delves into the intricate mechanisms and far-reaching effects of mitophagy in a variety of medical conditions. The book begins with an insightful overview of mitophagy, laying the foundation for a comprehensive exploration of its role in aging cardiomyopathy, cardiovascular diseases, neurological disorders, and neurodegenerative diseases. Moving forward, the book addresses the growing interest in natural remedies. It investigates the role that herbs play in promoting mitophagy to cope with disorders. Readers will explore the therapeutic potential of herbs, and the effects of yoga, opening new avenues for treatment and management. Readers will gain a deep understanding of how this selective degradation and recycling process affects these medical conditions and how it can potentially be targeted for therapeutic interventions. With current understanding and future perspectives, readers will grasp the significance of mitophagy in various biological processes and the potential implications for enhancing cell function and overall well-being in older adults. Mitophagy and its Role in Health and Disease is a one-of-a-kind resource that brings together cutting-edge research, in-depth analysis, and future perspectives on mitophagy. This book holds tremendous value for researchers, medical professionals, and students seeking to expand their knowledge regarding the role of mitophagy in aging, disease processes, and therapeutic interventions. Don't miss the chance to embark on a riveting journey into the world of mitophagy and its profound impact on human health.

Immune landscape of pancreatic cancer development and drug resistance explores the advances in immune-based therapies aimed at harnessing the power of the immune system against pancreatic cancer and rewiring tumor microenvironments to eradicate pancreatic cells. With a strong focus on the development of therapeutic methods to improve the survival rates of pancreatic cancer, this book also shows the latest trends in immune targeted approaches for pancreatic cancer treatment. In 12 chapters Immune landscape of pancreatic cancer development and drug resistance discusses the current understanding of PC development and its various mutational and immune features and explore some of the new immune-based therapies aimed at targeting pancreatic cancer. It covers the urgent need for developing novel therapeutic modalities and aims at delineating future fields and avenues of research in pancreatic cancer treatment. The book provides the reader with an updated understanding of the immune landscape of PC and an all-encompassing overview of the latest trends in immune targeted approaches for PC treatment. This book is a valuable resource for health professionals, scientists and researchers, students, and all those who wish to broaden their knowledge of the advances in immunotherapy in pancreatic cancer. - Summarizes the potential combination strategies and latest clinical trials in pancreatic cancer - Provides an in-depth overview of our current understanding of pancreatic cancer development, including its mutational and immune features - Explores some of the new immune-based therapies aimed at targeting PC - Shows pancreatic cancer progression and basic elements in tumor microenvironments and their role in PC progression, also covering immunotherapy strategies

This Handbook on cancer biology comprehensively reviews the current status of the oncobiology of major cancer types, cancer detection and treatment strategies, principles and processes of cancer drug development, and nanomedicine and other emerging cancer medicine applications to cancer diagnosis and treatment. The book also provides practical and implementable nutritional guidance in cancer prevention, treatment, and quality of life for cancer survivors. It discusses pharmacogenetics strategies for predicting cancer prognosis and treatment exposure, response, and toxicity. Further, it presents bioinformatics approaches for predicting anti-cancer drugs and drug combinations based on the multi-omic data, including transcriptomics, toxicogenomics, functional genomics, and biological networks. The Handbook also examines major factors and pathways that regulate cancer stem cells development and discusses potential targeted therapy for cancer stem cells. The book explores the application of the CRISPR/Cas9-based gene-editing technique in basic cancer research, diagnosis, and treatment of cancer. This Handbook is an invaluable source for oncologists, researchers, public health specialists, epidemiologists, and policy makers.​

Melatonin: A Ubiquitous Pleiotropic Molecule equips researchers with an understanding of the molecular biology of melatonin in plants. The book explores the occurrence of melatonin in several plant species, covering key aspects, including its biosynthesis, physiological function in plant growth and development, and signaling pathways. It then discusses the benefits melatonin has for plant and agricultural development, as well as how it can be utilized as a therapeutic in the treatment of human diseases. The role it can play in the oxidative stress response and circadian rhythm modulation are covered, as well as its nutraceutical potential for human health. The book also covers the importance of melatonin in a range of fields, including drug discovery and disease resistance, agriculture, botany, and biotechnology, and is an ideal reference for researchers across these disciplines.Examines melatonin's pivotal role as a signaling molecule, elucidating its involvement in a diverse array of biological responses within plantsCovers essential aspects like melatonin biosynthesis, regulation, antioxidant properties, and its involvement in stress management in plantsProvides an interdisciplinary study of melatonin and its potential uses, including disease management, crop improvement, and nutraceutical developmentAddresses melatonin's multifaceted role in regulating key physiological processes in the human body, including circadian rhythms, sleep–wake cycles, and neurological protectionDelves into melatonin's dual role as an immunomodulator influencing immune cells and a powerful antioxidant combating free radicals and alleviating oxidative stressExplores melatonin's therapeutic and anticancer potential, emphasizing its importance in cardiovascular health, neurology, and cancer research, attributed to its antioxidant and anti-inflammatory characteristics

The study of paleopathology has two very different constituencies, the medical scientist and the zoologist/paleontologist/anthropologist. Their investigative procedures and professional jargon are different, sometimes to the point of mutual incomprehensibility. Paleontologists/anthropologists/zoologists have a limited data base for the characterization and interpretation of pathology. This must come from the human and veterinary medical experience.What, beyond intellectual satisfaction, can the health care community expect from this relationship? The past history of the appearance and dispersal of infectious disease and cancer is of considerable theoretical importance and leads to new insights on the nature and transmission of diseases that are otherwise ambiguous. The discovery of rheumatoid arthritis in pre-Columbian North America exemplifies insights gained.The current effort delineates osseous impact of disease (as manifest in clinical populations diagnosed in life), representation in the zoologic, paleontologic and anthropologic record, and assessment techniques that can be confidently applied. The chapters form “columns” that provide the foundation for scientific critical thinking. The actual integration of the information is in its application. Our purpose is to provide a data base and atlas of actually documented skeletal impact of diseases (as population phenomenon), an initial data base of reported skeletal pathology, and a methodology for expanding this to new arenas.The first section of the book examines the scientific basis of paleopathology, its transition from speculation-based musings, resolution of misconceptions and the denouement of paleo-epidemiology. The second section provides holistic analysis of the gamut of pathology/diseases with significant skeletal impact, with a validated archeologic/zoological/paleontological record. The third section provides a glossary to resolve the semantic challenges inherent to interdisciplinary efforts. The fourth section provides an atlas of pathology representation in the fossil record. Ultimately, this book intends to present a scientifically-validated approach to recognition of disease in the archeological, zoological and paleontological record, superseding previous speculation-based offerings.

The field of cancer therapeutics faces significant challenges, including limited treatment options with adverse side effects and the emergence of drug resistance. Traditional approaches often fall short of providing effective and safe treatments, leaving a critical gap in addressing this widespread disease. Natural Products as Cancer Therapeutics offers a compelling solution to these challenges by exploring the untapped potential of bioactive compounds derived from natural products. This book, authored by esteemed scholars in biochemistry and pharmacology, provides a comprehensive examination of these compounds and their diverse pharmacological benefits. By harnessing the power of nature, this book presents a fresh perspective on cancer treatment, showcasing the promising alternative offered by natural products. With its cutting-edge research and insights, Natural Products as Cancer Therapeutics has the potential to revolutionize the field of oncology. Expanding the repertoire of treatment options and emphasizing the safety and efficacy of natural compounds, this book empowers researchers, practitioners, and scholars to explore new avenues in cancer therapeutics. Ultimately, this transformative resource has the power to improve patient outcomes and contribute to the ongoing battle against cancer.

Microbial Bioreactors for Industrial Molecules Harness the planet's most numerous resources with this comprehensive guide Microorganisms constitute the invisible majority of all living creatures on Earth. They are found virtually everywhere on the planet, including in environments too extreme for any larger organisms to exist. They form a hugely significant resource whose potential value for human society cannot be overlooked. The creation of microorganism- based bioreactors for the industrial production of valuable biomolecules has the potential to revolutionize a range of industries and fields. Microbial Bioreactors for Industrial Molecules provides a comprehensive introduction to these bioresources. It covers all potential approaches to the use of microbial technology and the production of high-value biomolecules for the pharmaceutical, cosmetic, and agricultural industries, among others. The book's rigorous detail and global, holistic approach to harnessing the power of the planetary microbiome make it an invaluable introduction to this growing area of research and production. Readers will also find: Detailed coverage of basic, applied, biosynthetic, and translational approaches to the use of microbial technology Discussion of industrially produced microbe-borne enzymes including invertase, lipase, keratinase, protease, and more Approaches for using microbial bioreactors to generate biofuels Microbial Bioreactors for Industrial Molecules is essential for scientists and researchers in microbiology and biotechnology, as well as for professionals in the biotech industries and graduate students studying the applications of the life sciences.

Polymer-Drug Conjugates: Linker Chemistry, Protocols and Applications discusses important concepts, fundamentals and prospective applications of'Linker Chemistry'in a clear-and-concise manner. The book provides vital information on chemical entities binding with the drug-polymer complex for targeted drug delivery systems. It highlights roles and significance, different classes and synthetic protocols as well as mechanisms of chemical bond formation in drug-polymer conjugation in drug delivery, also offering insights into the mechanism of polymer interaction with linker and drug molecules by biodegradable chemical bonding. The protocol of binding with drug molecules is clearly explained and justified with case studies, helping researchers and advanced students in the pharmaceutical sciences understand fundamentals involved and related aspects in molecule designing for effective therapeutic benefits. - Covers mechanism, protocol and therapeutic significance of Polymer-Drug Conjugates - Outlines updated methods and techniques to enumerate conjugation with related case studies - Includes comprehensive compilation of marketed and clinical trial drugs conjugated with polymers or linkers

Numerical Methods in Turbulence Simulation provides detailed specifications of the numerical methods needed to solve important problems in turbulence simulation. Numerical simulation of turbulent fluid flows is challenging because of the range of space and time scales that must be represented. This book provides explanations of the numerical error and stability characteristics of numerical techniques, along with treatments of the additional numerical challenges that arise in large eddy simulations. Chapters are written as tutorials by experts in the field, covering specific both contexts and applications. Three classes of turbulent flow are addressed, including incompressible, compressible and reactive, with a wide range of the best numerical practices covered. A thorough introduction to the numerical methods is provided for those without a background in turbulence, as is everything needed for a thorough understanding of the fundamental equations. The small scales that must be resolved are generally not localized around some distinct small-scale feature, but instead are distributed throughout a volume. These characteristics put particular strain on the numerical methods used to simulate turbulent flows. - Includes a detailed review of the numerical approximation issues that impact the simulation of turbulence - Provides a range of examples of large eddy simulation techniques - Discusses the challenges posed by boundary conditions in turbulence simulation and provides approaches to addressing them

Cancer Stem Cells and Signaling Pathways explores the mechanism of cancer stem cell signaling pathways in cancer advancement, serving as an ideal reference guide for investigators with valuable answers to problems associated with anti-cancer treatments and an understanding of the crosstalk among the signaling pathways in CSC regulation. Despite recent advances in tumor therapy and a greater understanding of their biology, tumors continue to be a prevalent and fatal worldwide. According to a novel paradigm in tumor biology, a small percentage of the cells within a tumor known as cancer stem cells (CSCs) are predicted as a crucial population for tumor progression. - Presents cancer stem characteristics and their signaling pathways - Highlights the use of animal models for cancer research, the use of genetically modified stem cells to deliver antitumor agents, and the significance of stem cell signaling in drug discovery - Covers basic and translational research appropriate for scientists and clinicians exploring alternative treatments for various cancers

​This book presents drug repurposing strategies to combat infectious diseases and cancer. It discusses key experimental and in silico approaches for modern drug repositioning, including signature matching, molecular docking, genome-wide associated studies, and network-based approaches aided by artificial intelligence. Further, the book presents various computational and experimental strategies for better understanding disease mechanisms and identify repurposed drug candidates for personalized pharmacotherapy. It also explores the databases for drug repositioning, summarizes the approaches taken for drug repositioning, and highlights and compares their characteristics and challenges. Towards the end, the book discusses challenges and limitations encountered in computational drug repositioning.

Spontaneous Pathology of the Laboratory Non-human Primate serves as a'go to'resource for all pathologists working on primates in safety assessment studies. In addition, it helps diagnostic veterinary pathologists rule out spontaneous non-clinical disease pathologies when assigning cause of death to species in zoological collections. Primate species included are rhesus, cynomolgus macaques and marmosets. Multi-authored chapters are arranged by organ system, thus providing the necessary information for continued research.Pathologists often face a lack of suitable reference materials or historical data to determine if pathologic changes they are observing in monkeys are spontaneous or a consequence of other treatments or factors. - Contains color illustrations that depict the most common lesions to augment descriptions - Covers descriptions that are compliant with the International Harmonization of Nomenclature and Diagnostic Criteria (INHAND) guidelines set forth by the Society of Toxicologic Pathology (STP) - Provides pathologists with common terms that are compliant with the FDA's Standard for Exchange of Nonclinical Data (SEND) guidelines

Role of Nanotechnology in Cancer Therapy gives an overview of the innovative nanocarrier-based approaches for managing various cancers such as gastric, skin, lung, and prostate cancers. The book also explores the evolving targeting approaches specific to cancer and the immunotherapy-based nanomedicinal approach. Several drug-delivery systems which reduce the overall toxicity of cytotoxic drugs and increase their effectiveness and selectivity are also discussed in this book.Key Features- Discusses the potential benefits and therapeutic applications of nanoparticles in cancer management- Provides information about therapy in a range of cancers- Discusses recent developments in cancer nanomedicine including targeted therapy, immonotherapy nanoparticles and dual drug delivery- Includes safety and toxicity considerations- Provides references for advanced readersThis book will inform a broad range of readers including undergraduate and postgraduate students, oncologists, pharmacists, and researchers involved in nanomedicine and nano-drug delivery about current advancement in cancer nanomedicine.

Fluorescence is the most popular technique in chemical and biological sensing because of its ultimate sensitivity, high temporal and spatial resolution and versatility that enables imaging within the living cells. It develops rapidly in the directions of constructing new molecular recognition units, new fluorescence reporters and in improving sensitivity of response up to detection of single molecules. Its application areas range from control of industrial processes to environment monitoring and clinical diagnostics. This book provides systematic knowledge of basic principles in design of fluorescence sensing and imaging techniques together with critical analysis of recent developments. Being a guide for students and young researchers, it also addresses professionals involved in active basic and applied research. Making a strong link between education, research and product development, this book discusses prospects for future progress.

Nanotechnology Principles in Drug Targeting and Diagnosis focuses on the nanotechnology principles and mechanisms involved in drug targeting, nano carriers and target interactions associated with particular diseases. The book addresses how phytotherapeutics are effective against solid tumors and how they can be used in designing targeted delivery systems. Also addressed is the use of macrophages as the biomimetic carrier for targeting drugs to different organs. Sections cover the nanotechnology-based concepts in drug targeting, strategies for drug targeting, ways to identify drug carrier-target interaction, the concept of an artificial neural network in identifying drug-target interaction, and more.The book's final section concentrates on the role of nanotechnology in medical diagnosis, throwing light on nanoscale sensors for the diagnosis of viruses in the bloodstream and biomarkers indicating various cancers. This is an important reference source for materials scientists and pharmaceutical scientists who want to understand how nanotechnology plays an important role in creating more efficient drug targeting and delivery systems. - Provides extensive coverage of methods of drug-carrier-target identification and the capability of artificial intelligence to recognize patterns in patients using these patterns for nanocarrier design - Helps readers understand how nanocarriers must be functionalized for effective targeted delivery and how they can be useful tools for personalized and precise treatment of diseases - Assesses the role of nanoscale sensors in the early detection of cancer cells in the bloodstream

Research shows that that children learn science and engineering subjects best by engaging from an early age in the kinds of practices used by real scientists and engineers. By doing science and engineering, children not only develop and refine their understanding of the core ideas and crosscutting concepts of these disciplines, but can also be empowered to use their growing understanding to make sense of questions and problems relevant to them. This approach can make learning more meaningful, equitable, and lasting. Using cases and shorter examples, Rise and Thrive with Science shows what high-quality teaching and learning in science and engineering can look like for preschool and elementary school children. Through analyses of these examples and summaries of research findings, the guide points out the key elements of a coherent, research-grounded approach to teaching and learning in science and engineering. This guide also discusses the kinds of support that educators need to implement effective and equitable instruction for all children. This book will provide inspiration for practitioners at the preschool and elementary levels to try new strategies for science and engineering education, whatever their level of experience. Rise and Thrive with Science will be an essential guide for teachers as they organize instruction to enable young children to carry out their own science investigations and engineering design projects, determine the kinds of instruction that lead to meaningful learning, and try to engage every one of their students.

This book aims to provide an association of the major redox-sensitive pathways and networks involved in cancer. The initial chapter of the book discusses basic information about oxidative stress, its generation, and regulation (redox regulation or redox homeostasis) via cell signaling in normal and cancer cells. The book also explores antioxidants and metabolic events in cancer cells compared to normal cells. It further covers the application of nanoparticles in redox regulation in cancer cells. The role of redox regulation in cancer therapy, its influence, and its involvement in programmed cell death (PCD), metastasis, immune system, p53, and cell cycle/DNA damage repair pathways have been discussed in separate chapters. It further reviews the importance of dietary phytochemicals in redox regulation in normal and cancer pathophysiology. Towards the end, the book focuses on the role of redox balance, especially in ROS-dependent cellular processes in cancer stem cells.

MULTI-DRUG RESISTANCE IN CANCER The book details the mechanisms underlying multi-drug cellular resistance and the targets of novel chemotherapeutic agents. Cancer is a major killer all over the world. Even with all the progress made, chemotherapy is still the mainstay of modern cancer treatment. The progression of the cellular defeat of numerous independent anticancer drugs in terms of their chemical structure is a major barrier to successful chemotherapy. Multi-drug resistance (MDR) is a term for the fact that most cancer patients exhibit this phenomenon. According to the numbers, drug resistance carries the blame for 90% of cancer patient deaths. Refractory cancer and tumor recurrence are common outcomes of prolonged chemotherapy. Because of the prevalence of drug-resistance mutations, the difficulty of treating tumors increases and the therapeutic efficacy of drugs decreases. Multi-Drug Resistance in Cancer: Mechanism and Treatment Strategies contains nine chapters that cover topics such as: studying the mechanics of resistance to drugs by autophagy; studies to delineate the role of efflux transporters; expression of drug transporters; resistance to targeted therapies in breast cancer; advances in metallodrug driven combination treatment for cancer; and use of natural agents for the overcoming of cancer drug resistance. The book aims to provide the latest data on the mechanisms of cellular resistance to anticancer agents currently used in clinical treatment. It provides a better understanding of the mechanisms of MDR and targets of novel chemotherapy agents which should guide future research concerning new effective strategies in cancer treatment. Audience This book is written for pharmaceutical and biomedical scientists and researchers at both the bench and in the clinic who are interested in the mechanisms and strategies for overcoming cancer's multi-drug resistance.

«Antonis Balasopoulos is to be heartily thanked for bringing back into print A. L. Morton's marvelous book The English Utopia – and for providing us with not only a useful and insightful Introduction, but also a comprehensive bibliography of Leslie Morton's many writings. We definitely need such works in these difficult times when democracy is under siege by authoritarian forces. Morton's chapters may well truly serve both to empower our critical thinking and to inspire our radical-democratic imaginations.» (Harvey J Kaye, Professor Emeritus of Democracy & Justice, University of Wisconsin-Green Bay) «Antonis Balasopoulos describes his job as an ‘exercise in historical reclamation.'He is due much gratitude for both the scrupulousness and the expertise he brings to his task. The Introduction is a model of its kind, positioning Morton in his own milieu as a committed intellectual. Morton's book more than deserves this careful attention. In this new Ralahine edition, The English Utopia appears as the seminal text in utopian studies it should have been. » (Patricia McManus, Senior Lecturer, School of Humanities and Social Science, University of Brighton) A. L. Morton's classic 1952 study of utopias in the context of British social history constitutes one of the earliest sustained engagements with the social and ideological sources of the utopian imagination, the importance of the class struggle for literary production and of literary production for cultural, if not political hegemony. Traversing English literary history from the medieval poem on the Land of Cockaygne to Sir Thomas More, to William Morris's News from Nowhere and the subsequent decline of the genre and the eventual rise of anti-utopian and dystopian strains in the early twentieth century, The English Utopia remains provocative and critically engaging more than seventy years after its original publication. In addition to charting its significance as an intervention, the present edition also brings to light Morton's complex role as Left political activist, historian, scholarly catalyst and cultural critic – a paradigmatic instance of the engaged and public intellectual.

Cancer is a leading cause of death worldwide, and the efficacy of cancer drugs is often limited due to poor bioavailability and drug resistance. Traditional treatment strategies, such as surgery, chemotherapy, radiotherapy, immunotherapy, and combinational regimens, are associated with side effects and fail to deliver an adequate amount of the drug to the target site. Chemotherapy has paved the way for novel drug delivery systems in cancer treatment, enhancing efficacy, patient compliance and reducing side effects by specifically targeting the site of action. These novel drug delivery systems employ various drug delivery systems such as nanoparticles, liposomes, niosomes, transferosomes, transdermal drug delivery systems, intranasal drug delivery systems, and others to improve drug solubility, stability, and controlled release patterns. The application of novel drug delivery systems in chemoimmunotherapy has become a hotspot in cancer treatment, and this book explores the potential of gene therapy alongside recent patents on anticancer formulations. The discussion also extends to clinical trials, which are crucial for validating these novel approaches and ensuring that effective treatments reach patients. The initial chapters provide an overview of current therapeutic approaches, while subsequent chapters focus on the role of nanotechnology in cancer treatment, emphasizing various nanoparticle-based formulations. Liposomes, transdermal drug delivery systems, microsomes, phytosomes, niosomes, intranasal drug delivery systems, and gene-drug delivery systems for cancer therapy are also discussed. Furthermore, the book addresses novel drug delivery systems, patents, and ongoing clinical trials, offering valuable insights for researchers, academicians, and scientists working towards advancements in the therapeutic management of cancer.

This book reviews the potential effect of diet modification, lipids, and carbohydrate consumptions, vitamin supplementation, antioxidants, and nutraceuticals in the prevention and management of Alzheimer's disease. The initial chapter of the book presents the pathophysiological mechanisms, risk factors, genetic predisposition, disease diagnosis, pathology, and current treatment strategies against Alzheimer's disease. It also highlights recent developments in exploring novel compounds for the prevention and treatment of Alzheimer's disease. Subsequently, it highlights the therapeutic effect and regulation of molecular targets by natural compounds. The book discusses the potential of natural compounds in inhibiting the formation and deposition of Aβ peptides. It examines the natural compounds in modulating intracellular signaling molecules and enzymes involved in the pathogenesis of Alzheimer's disease. In summary, this book helps understand the role of natural compounds as a therapeutic approach in amelioration and preventing detrimental effects of Alzheimer's disease.

This book is a comprehensive resource for veterinary oncologists and trainees, covering therapeutic strategies used in the treatment of veterinary patients. In the setting of a rapidly changing field like oncology, this timely text focuses on mechanisms of action and biological rationale rather than current specific clinical recommendations, allowing current and future clinicians to adapt treatment approaches as our understanding of the biology of cancer evolves. With each chapter written by experts in their field, this book provides informative figures that convey this biological understanding and rationale of therapy. It starts from the mechanisms of treatment as we currently understand them, covering radiation therapy, chemotherapy, immunotherapy, targeted therapy, and many more. Dispensing vital, detailed and practical information about the different therapeutic strategies available, this book is a vital resource for practicing veterinarians, while also providing students of veterinary oncology with a better understanding of the key differences between different treatment strategies.

This book illustrates the significance of probiotics and prebiotics for the management of various types of cancers. The up-to-date chapters provide recent information about the effect of anticancer treatment approaches on gut microbiota, the correlation between ROS and synbiotics for effective cancer treatment, and the influence of synbiotics on inflammation and immune microenvironment for cancer treatment. It also describes the regulatory issues about synbiotics in the management of cancer. This book is an essential resource for scientists working in the field of cancer, pharmaceutical & clinical sciences, and cancer clinicians. This book is also very useful for undergraduate and postgraduate students of Pharmacy and Biotechnology and medical researchers, mainly working in microbiology, immunology, and cancer biology.

Phytochemicals have been present in human diet and life since the birth of mankind, including the consuming of plant foods and the application of herbal treatments. This coevolutionary interaction of plants and people has resulted in humans'reliance on food and medicinal plants as sources of macronutrients, micronutrients, and bioactive phytochemicals. Phytochemicals can be used as adjuvant agents and sensitizers in traditional antibiotic and anticancer therapy, reducing the potential of selecting resistant microbial strains and cancer cells. Recent Frontiers of Phytochemicals addresses the many processes of potential phytochemical evaluation of known sources, with a focus on phytochemical and pharmacological evaluations, and computational research into the structures and pharmacological mechanisms of natural products and their applications in medicine, food and biotech. - Novel extraction, characterization, and application method for phytochemicals in food, pharmacology, and biotechnology - Colour illustrations and extensive tables with state-of-art information - Covers potential sources of phytochemicals, their extraction and characterization techniques

This book explores the interrelationship of genetics, the environment, or both, in the causation of three neurodevelopmental disorders: autism/autism spectrum disorder (ASD), fetal alcohol spectrum disorder (FASD), and cerebral palsy (CP). It links common clinical problems in developmental pediatrics and pediatric neurology to current concepts and translational research advances in developmental neurosciences, medical genetics, and related disciplines. The first section of the book provides a comprehensive and up-to-date overview of development of the brain, including topics such as neuronal stem cells, epigenetics, and the influence of the prenatal environment. The next three sections analyze the epidemiology, diagnosis, interventions, and controversies and research directions associated with each of the three neurodevelopmental disorders. It also examines co-morbidities common to all three disorders, such as disturbed sleep, seizures, behavioral disorders, and pain. It concludes by highlighting the impact of ASD, FASD, and CP on family dynamics and provides tools and resources based on foundational concepts such as neuroethics, bioinformatics, community engagement, and advocacy. Learning objectives, key points, clinical vignettes, and multiple choice questions are incorporated throughout the book. With its comprehensive treatment of disease mechanisms, genetics, and pathophysiology associated with these disorders and its discussion of potential therapies and novel treatments, Neurodevelopmental Pediatrics: Genetic and Environmental Influences is an essential resource for developmental pediatricians, child neurologists, fellows, residents and graduate students.

Cancer treatment is a challenging issue, while the treatment modalities have extended from traditional surgery, chemotherapy, and radiation therapy to new therapeutic approaches, including targeted therapy, immunotherapy, stem cell transplantation, and hormone therapy. Therefore, an interdisciplinary approach is needed to find a better therapeutic protocols in order to increase the prognosis and quality of life of patients with cancer. The second volume of the “Interdisciplinary Cancer Research” series, entitled “Cancer Treatment: An Interdisciplinary Approach” publishes comprehensive volumes on different cancer treatment modalities and presents the most updated and peer-reviewed articles on cancer therapy. This interdisciplinary series is of special value to researchers and practitioners working on cell biology, immunology, hematology, biochemistry, genetics, oncology and related fields. This is the main concept of Cancer Immunology Project (CIP), which is a part of Universal Scientific Education and Research Network (USERN). This interdisciplinary book will be of special value for researchers and clinicians who wish to extend their knowledge on cancer treatment.