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This book describes general glycobiology in emphasizing the structures, biosynthesis, glycosylation and distribution of the glycans and xenogenic glycoantigens in eukaryotic cells of mammals including mouse, swine, chimpanzee and human. In the middle, I have focused on topics in xenotransplantation glycobiology and expand descriptions of allogenic and xenoantigenic transplantation to open the dawn in insights into the origin of life. One of the biological diversity, named species diversity, is a phenomenon environmentally adapted from the evolutionary process for long period. The distinct structures of glycans discriminate each organism and are the essential molecular basis of the discrimination and difference between the organisms, giving an incompatibility between the different species. Diversity and variations in carbohydrate chain structures between family, species, kingdoms and domains mark the global pattern and signs of immune self- and non-self recognition. In human, diversity in ABH blood group antigens is observed in human family and this type pattern distinguishes individuals from a pan-family to non-dividable unit of the family. Blood transfusion and organ transplantation are impossible even in the allogenic cross between humans if carbohydrates are ignored. This explains how and how human beings are a lonely existence. ABH-related antibodies induce hemolysis or hyperacute or allograft rejection due to incompatible graft property even between the same species. The incompatibility is an immunologic rejection when the recipient host receives the tissues or organs from the different species of donors, as well-known in pig-to-human xenotransplantation. The immunologic incompatibility between the donor pigs and the recipient human are based on the evolutionary distance between pigs and humans. This distance allows a xenograft rejection between the 2 mammals. Modification or deletion of the specific gene locus for immune rejection on genome of donor animalsdisrupts the immunological recognition ligands of the donor organs, consequently preventing the immune rejection of the human recipient and xenograft rejection. This book helps undergraduate and graduate students, researcher and professors who are involved in the glycobiology and xenoantigenic biology with recent advances in the xenotransplantation basic and clinic.

This proceeding comprises peer-reviewed papers of the 2021 Asia-Pacific International Symposium on Aerospace Technology (APISAT 2021), held from 15-17 November 2021 in Jeju, South Korea. This book deals with various themes on computational fluid dynamics, wind tunnel testing, flow visualization, UAV design, flight simulation, satellite attitude control, aeroelasticity and control, combustion analysis, fuel injection, cooling systems, spacecraft propulsion and so forth. So, this book can be very helpful not only for the researchers of universities and academic institutes, but also for the industry engineers who are interested in the current and future advanced topics in aerospace technology.

This proceeding comprises peer-reviewed papers of the 2021 Asia-Pacific International Symposium on Aerospace Technology (APISAT 2021), held from 15-17 November 2021 in Jeju, South Korea. This book deals with various themes on computational fluid dynamics, wind tunnel testing, flow visualization, UAV design, flight simulation, satellite attitude control, aeroelasticity and control, combustion analysis, fuel injection, cooling systems, spacecraft propulsion and so forth. So, this book can be very helpful not only for the researchers of universities and academic institutes, but also for the industry engineers who are interested in the current and future advanced topics in aerospace technology.

This book presents comprehensive studies of charge density waves (CDW) in a high-Tc cuprate superconductor using x-ray scattering techniques under uniaxial pressure. Specifically, the work addresses inelastic x-ray scattering studies under uniaxial pressure performed on the underdoped cuprate YBa2Cu3O6.67(p=0.12, Tc=65K) with incoming photon energy in the resonant (E=931.3 eV, Cu-L3 edge) and non-resonant conditions (E=17.794 keV). This is a completely new approach to the investigation of charge density waves. It revealed new features of charge density waves in cuprates, whose properties had previously been inaccessible..

This book presents the latest knowledge and the most recent research results on glycobiology of innate immunology. Innate immunity is the crucial part of the immunological defense system that exerts their distinct functions through binding to certain functional glycoproteins. They play a role in various human diseases and also function against microbial invaders and self-associated molecular patterns. Co-regulated expression of glycan-binding is associated with many biological components such as cellular oncotransformation, phenotype change, neuronal or embryonic development, regulation of cell division, cell–cell interaction, cell attachment, adhesion, and motility, and intracellular signaling via protein–carbohydrate or carbohydrate–carbohydrate interactions.This book opens by providing the key background on glycans in innate immunity and its mechanisms behind the Dendritic cell interactions during infection and inflammation are examined in depth, and the concluding chapter is devoted to signaling tumor immunotherapy. Up-to-date information is then presented on all aspects of glycan structure-recognizing signaling. The book should assist in the further development of new strategies against emerging infectious agents and intractable diseases.

This book presents the latest knowledge and the most recent research results on glycosphingolipid (GSL)-mediated signaling. GSLs are important constituents of the plasma membrane that exert their distinct functions through binding to certain functional proteins. They play a role in various human diseases and also function as human alloantigens. Cellular GSLs are associated with many biological functions such as cellular oncotransformation, phenotype change, neuronal or embryonic development, regulation of cell division, cell–cell interaction, cell attachment, adhesion, and motility, and intracellular signaling via protein–carbohydrate or carbohydrate–carbohydrate interactions. This book opens by providing the key background on GSL glycan–receptor interactions and mammalian GSL synthesis. Up-to-date information is then presented on all aspects of GSL-dependent signaling. Viral protein and bacterial toxin protein interactions with host cell GSLs are examined in depth, and the concluding chapter is devoted to signaling regulation. The book should assist in the further development of new strategies against emerging infectious agents and intractable diseases.

This book presents the latest knowledge and the most recent research results in the field of ganglioside biochemistry. The early chapters cover all relevant background on sialic acids and their biosynthesis, on N-glycolylneuraminic acid (Neu5Gc), which cannot be synthesized by humans, and on general aspects of ganglioside research. Ganglioside adsorption, disorders of ganglioside degradation, and the regulation of gangliosides are thoroughly discussed. A major focus of the book is the role of gangliosides in cancer. Here, the discussion encompasses, for example, the biological importance, antigenicity, and immunological actions of tumor-associated gangliosides (TAGs), the significance of different glycolipids and gangliosides as TAGs, and emerging anti-cancer vaccine strategies. The ability of sialic acids and TAGs of tumor cells to escape immunosurveillance and immunoediting also receives detailed attention. The significance of sialic acids in regulation of the complement system is explained, and the closing chapter focuses especially on the role of sialyl T antigen in cancer. The book will be of value for all who are interested in functional glycobiology and glycomic studies.

'This book is about the Chemistry of Korean Foods and Beverages'--

This book brings Korea's finest foreign policy minds together in contemplating the risks and rewards of finally ending the 70 year stalemate between North and South Korea through reunification. While North Korea is in conflict with the United States over denuclearization and regime security, the South Korean government is focusing on economic development preparing for the day when the two Koreas are unified. This book will help scholars, activists and policy-makers from all over the world systematically understand the current diplomatic and security issues in the Korean peninsula.

Introduces the basic concepts of FEM in an easy-to-use format so that students and professionals can use the method efficiently and interpret results properly Finite element method (FEM) is a powerful tool for solving engineering problems both in solid structural mechanics and fluid mechanics. This book presents all of the theoretical aspects of FEM that students of engineering will need. It eliminates overlong math equations in favour of basic concepts, and reviews of the mathematics and mechanics of materials in order to illustrate the concepts of FEM. It introduces these concepts by including examples using six different commercial programs online. The all-new, second edition of Introduction to Finite Element Analysis and Design provides many more exercise problems than the first edition. It includes a significant amount of material in modelling issues by using several practical examples from engineering applications. The book features new coverage of buckling of beams and frames and extends heat transfer analyses from 1D (in the previous edition) to 2D. It also covers 3D solid element and its application, as well as 2D. Additionally, readers will find an increase in coverage of finite element analysis of dynamic problems. There is also a companion website with examples that are concurrent with the most recent version of the commercial programs. Offers elaborate explanations of basic finite element procedures Delivers clear explanations of the capabilities and limitations of finite element analysis Includes application examples and tutorials for commercial finite element software, such as MATLAB, ANSYS, ABAQUS and NASTRAN Provides numerous examples and exercise problems Comes with a complete solution manual and results of several engineering design projects Introduction to Finite Element Analysis and Design, 2nd Edition is an excellent text for junior and senior level undergraduate students and beginning graduate students in mechanical, civil, aerospace, biomedical engineering, industrial engineering and engineering mechanics.

This book explores in depth a wide range of new biomaterials that hold great promise for applications in regenerative medicine. The opening two sections are devoted to biomaterials designed to direct stem cell fate and regulate signaling pathways. Diverse novel functional biomaterials, including injectable nanocomposite hydrogels, electrosprayed nanoparticles, and waterborne polyurethane-based materials, are then discussed. The fourth section focuses on inorganic biomaterials, such as nanobioceramics, hydroxyapatite, and titanium dioxide. Finally, up-to-date information is provided on a wide range of smart natural biomaterials, ranging from silk fibroin-based scaffolds and collagen type I to chitosan, mussel-inspired biomaterials, and natural polymeric scaffolds. This is one of two books to be based on contributions from leading experts that were delivered at the 2018 Asia University Symposium on Biomedical Engineering in Seoul, Korea – the companion book examines in depth the latest enabling technologies for regenerative medicine.

This book introduces the methods for predicting the future behavior of a system's health and the remaining useful life to determine an appropriate maintenance schedule. The authors introduce the history, industrial applications, algorithms, and benefits and challenges of PHM (Prognostics and Health Management) to help readers understand this highly interdisciplinary engineering approach that incorporates sensing technologies, physics of failure, machine learning, modern statistics, and reliability engineering. It is ideal for beginners because it introduces various prognostics algorithms and explains their attributes, pros and cons in terms of model definition, model parameter estimation, and ability to handle noise and bias in data, allowing readers to select the appropriate methods for their fields of application.Among the many topics discussed in-depth are:•Prognostics tutorials using least-squares•Bayesian inference and parameter estimation•Physics-based prognostics algorithms including nonlinear least squares, Bayesian method, and particle filter•Data-driven prognostics algorithms including Gaussian process regression and neural network•Comparison of different prognostics algorithms The authors also present several applications of prognostics in practical engineering systems, including wear in a revolute joint, fatigue crack growth in a panel, prognostics using accelerated life test data, fatigue damage in bearings, and more. Prognostics tutorials with a Matlab code using simple examples are provided, along with a companion website that presents Matlab programs for different algorithms as well as measurement data. Each chapter contains a comprehensive set of exercise problems, some of which require Matlab programs, making this an ideal book for graduate students in mechanical, civil, aerospace, electrical, and industrial engineering and engineering mechanics, as well asresearchers and maintenance engineers in the above fields.

This graduate-level textbook is a tutorial for item response theory that covers both the basics of item response theory and the use of R for preparing graphical presentation in writings about the theory. Item response theory has become one of the most powerful tools used in test construction, yet one of the barriers to learning and applying it is the considerable amount of sophisticated computational effort required to illustrate even the simplest concepts. This text provides the reader access to the basic concepts of item response theory freed of the tedious underlying calculations. It is intended for those who possess limited knowledge of educational measurement and psychometrics.Rather than presenting the full scope of item response theory, this textbook is concise and practical and presents basic concepts without becoming enmeshed in underlying mathematical and computational complexities. Clearly written text and succinct R code allow anyone familiarwith statistical concepts to explore and apply item response theory in a practical way. In addition to students of educational measurement, this text will be valuable to measurement specialists working in testing programs at any level and who need an understanding of item response theory in order to evaluate its potential in their settings.

Die Parusie wird traditionell im Themenkomplex der Naherwartungsverzögerung behandelt. Aufgrund dieses Interpretationsparadigmas wurden der Ereigniszusammenhang der lukanischen Parusieaussagen und die Struktur der eschatologischen Perspektiven des Lukas kaum beachtet. Das vorliegende Buch untersucht die lukanische Parusieauffassung nicht nur vor dem Hintergrund der innerchristlichen Tradition, sondern stellt diese in den traditionsgeschichtlichen Kontext der frühjüdischen'Parusievorstellungen'. Hierfür werden intensiv die frühjüdischen Schriften zu Zeitvorstellungen und Eschatologie untersucht und herangezogen.Die Parusie ist bei Lukas als ein mit der gegenwärtigen Herrschaft Christi verbundener integrierter Bestandteil des extendierten Christusgeschehens zu verstehen. Die Naherwartung zielt nicht auf einen vorhersagbaren Zeitpunkt, der verfehlt worden wäre, sondern bestimmt die eschatologische Dimension der alltäglichen'Wachsamkeit'.

The first of its kind, this comprehensive resource integrates cellular mechanobiology with micro-nano techniques to provide unrivalled in-depth coverage of the field, including state-of-the-art methods, recent advances, and biological discoveries. Structured in two parts, the first part offers detailed analysis of innovative micro-nano techniques including FRET imaging, electron cryo-microscopy, micropost arrays, nanotopography devices, laser ablation, and computational image analysis. The second part of the book provides valuable insights into the most recent technological advances and discoveries in areas such as stem cell, heart, bone, brain, tumor, and fibroblast mechanobiology. Written by a team of leading experts and well-recognised researchers, this is an essential resource for students and researchers in biomedical engineering.

A comprehensive portfolio optimization guide, with provided MATLAB code Robust Equity Portfolio Management + Website offers the most comprehensive coverage available in this burgeoning field. Beginning with the fundamentals before moving into advanced techniques, this book provides useful coverage for both beginners and advanced readers. MATLAB code is provided to allow readers of all levels to begin implementing robust models immediately, with detailed explanations and applications in the equity market included to help you grasp the real-world use of each technique. The discussion includes the most up-to-date thinking and cutting-edge methods, including a much-needed alternative to the traditional Markowitz mean-variance model. Unparalleled in depth and breadth, this book is an invaluable reference for all risk managers, portfolio managers, and analysts. Portfolio construction models originating from the standard Markowitz mean-variance model have a high input sensitivity that threatens optimization, spawning a flurry of research into new analytic techniques. This book covers the latest developments along with the basics, to give you a truly comprehensive understanding backed by a robust, practical skill set. Get up to speed on the latest developments in portfolio optimization Implement robust models using provided MATLAB code Learn advanced optimization methods with equity portfolio applications Understand the formulations, performances, and properties of robust portfolios The Markowitz mean-variance model remains the standard framework for portfolio optimization, but the interest in—and need for—an alternative is rapidly increasing. Resolving the sensitivity issue and dramatically reducing portfolio risk is a major focus of today's portfolio manager. Robust Equity Portfolio Management + Website provides a viable alternative framework, and the hard skills to implement any optimization method.

What does it mean to say that it is'We the People'who'ordain and establish'a constitution? Who are those sovereign people, and how can they do so? Interweaving history and theory, constitutional scholar Chaihark Hahm and political theorist Sung Ho Kim attempt to answer these perennial questions by revisiting the constitutional politics of postwar Japan and Korea. Together, these experiences demonstrate the infeasibility of the conventional assumption that there is a clearly bounded sovereign'people'prior to constitution-making that stands apart from both outside influence and troubled historical legacies. The authors argue that'We the People'only emerges through a deeply transformative politics of constitutional founding and, as such, a democratic constitution and its putative author are mutually constitutive. Highly original and genuinely multidisciplinary, this book will be of interest to democratic theorists and scholars of comparative constitutionalism as well as observers of ongoing constitutional debates in Japan and Korea.

This comprehensive atlas, containing a wealth of high-quality images, illustrates the complete spectrum of presentations of inflammatory bowel diseases (IBD). It focuses especially on the most recent developments in the use of endoscopy in IBD, providing detailed guidance on endoscopic indices of disease activity, diagnosis, and differential diagnosis. In addition to ileocolonoscopy, small bowel endoscopy, and esophagogastroduodenoscopy, chapters are included on the role of both established radiological techniques, such as CT, MRI, and abdominal ultrasonography, and the newest approaches, including high-resolution endoscopy, narrow band imaging, and confocal laser endomicroscopy. Extraintestinal manifestations and complications are addressed in separate chapters, and the book concludes by presenting surgical findings. The authors are international authorities with diverse expert knowledge who have collaborated to create an ideal tool for all who wish to master endoscopic evaluationin IBD.

Global warming, pollution, food and water shortage, cyberspace insecurity, over-population, land erosion, and an overburdened health care system are major issues facing the human race and our planet. These challenges have presented a mandate to develop “natural” or “green” technologies using nature and the living system as a guide to rationally design processes, devices, and systems. This approach has given rise to a new paradigm, one in which innovation goes hand-in-hand with less waste, less pollution, and less invasiveness to life on earth. Bioinspiration has also led to the development of technologies that mimic the hierarchical complexity of biological systems, leading to novel highly efficient, more reliable multifunctional materials, devices, and systems that can perform multiple tasks at one time. This multi-volume handbook focuses on the application of biomimetics and bioinspiration in medicine and engineering to produce miniaturized multi-functional materials, devices, and systems to perform complex tasks. Our understanding of complex biological systems at different length scales has increased dramatically as our ability to observe nature has expanded from macro to molecular scale, leading to the rational biologically-driven design to find solution to technological problems in medicine and engineering.The following three-volume set covers the fields of bioinspired materials, electromechanical systems developed from concepts inspired by nature, and tissue models respectively.The first volume focuses on the rational design of nano- and micro-structured hierarchical materials inspired by the relevant characteristics in living systems, such as the self-cleaning ability of lotus leaves and cicadas'wings; the superior walking ability of water striders; the anti-fogging function of mosquitoes'eyes; the water-collecting ability of Namib Desert Beetles and spider silk; the high adhesivity of geckos'feet and rose petals; the high adhesivity of mussels in wet aquatic environments; the anisotropic wetting of butterflies'wings; the anti-reflection capabilities of cicadas'wings; the self-cleaning functionality of fish scales; shape anisotropy of intracellular particles; the dielectric properties of muscles; the light spectral characteristics of plant leaves; the regeneration and self-healing ability of earthworms; the self-repairing ability of lotus leaves; the broadband reflectivity of moths'eyes; the multivalent binding, self-assembly and responsiveness of cellular systems; the biomineral formation in bacteria, plants, invertebrates, and vertebrates; the multi-layer structure of skin; the organization of tissue fibers; DNA structures with metal-mediated artificial base pairs; and the anisotropic microstructure of jellyfish mesogloea. In this volume, sensor and microfluidic technologies combined with surface patterning are explored for the diagnosis and monitoring of diseases. The high throughput combinatorial testing of biomaterials in regenerative medicine is also covered.The second volume presents nature-oriented studies and developments in the field of electromechanical devices and systems. These include actuators and robots based on the movement of muscles, algal antenna and photoreception; the non-imaging light sensing system of sea stars; the optical system of insect ocellus; smart nanochannels and pumps in cell membranes; neuromuscular and sensory devices that mimic the architecture of peripheral nervous system; olfaction-based odor sensing; cilia-mimetic microfluidic systems; the infrared sensory system of pyrophilous insects; ecologically inspired multizone temperature control systems; cochlea and surface acoustic wave resonators; crickets'cercal system and flow sensing abilities; locusts'wings and flapping micro air vehicles; the visual motion sensing of flying insects; hearing aid devices based on the human cochlea; the geometric perception of tortoises and pigeons; the organic matter sensing capability of ca

This book introduces the key concepts of nonlinear finite element analysis procedures. The book explains the fundamental theories of the field and provides instructions on how to apply the concepts to solving practical engineering problems. Instead of covering many nonlinear problems, the book focuses on three representative problems: nonlinear elasticity, elastoplasticity, and contact problems. The book is written independent of any particular software, but tutorials and examples using four commercial programs are included as appendices: ANSYS, NASTRAN, ABAQUS, and MATLAB. In particular, the MATLAB program includes all source codes so that students can develop their own material models, or different algorithms. Please visit the author's website for supplemental material, including PowerPoint presentations and MATLAB codes, at http://www2.mae.ufl.edu/nkim/INFEM/

Engineering drawing is the'instrument of communication'upon which the designer must place all information necessary to define a new product. Computer-aided design (CAD) courses often involve teaching solid modelling software, and we view CAD as an engineering communication tool for manufacturing. As the technology of engineering design is in transition from paper drawings to solid models, its education must address the challenge of covering both technologies. Geometry of design integrates drafting technology based on experience with engineering design education. This workbook has evolved from the course “Computer-Aided Graphics and Design” at the University of Florida, and many pages of this textbook can be used for student assignments. In order to help students to familiarize themselves with the manufacturing field experience, most assignments are to be submitted in the form of complete working drawings of the parts and assembly. The first three chapters introduce basic engineering drawing definitions and practices. The following four chapters cover design and descriptive geometry, and subsequent chapters move on to dimensions, assembly line design and surface development.

Elementary Particles and Their Interactions. Concepts and Phenomena presents a well-written and thorough introduction to this field at the advanced undergraduate and graduate level. Students familiar with quantum mechanics, special relativity and classical electrodynamics will find easy access to modern particle physics and a rich source of illustrative examples, figures, tables, and problems with selected solutions. Further references guide the reader through the literature. This text should become a standard reference to particle physics and will be useful to students and lecturers alike.

This edited volume brings Ahn Byung-Mu's minjung theology into dialogue with twenty-first-century readers. Ahn Byung-Mu was one of the pioneers of Korean minjung theology. The centerpiece of his minjung theology is focused on the Greek word ochlos, understood as the divested, marginalized, powerless people. Part 1 introduces readers to his life and theological legacy. Part 2 includes four important writings of Ahn Byung-Mu:'Jesus and Minjung in the Gospel of Mark,''Minjung Theology in the Gospel of Mark,''The Transmitters of Jesus Event Tradition,'and'Minjok, Minjung, and Church.'Part 3 contains a collection of articles from international scholars who evaluate and engage Ahn's ochlos/minjung theology in their own fields and formulate critical readings of minjung theology. Responses include postcolonial, black theology, and feminist perspectives.

Carbohydrate antigens on glycoconjugates of mammalian cells play crucial roles in various biological processes and are epitopes recognized by the immune system, as glycobiology has hugely been progressed during the past two decades. The book focuses on sialic acid–based xenoantigenes. In pig to human xenotransplantation, exposure of pig organs to human blood results in hyper acute rejection (HAR), caused by differences in carbohydrate epitopes between human and pig vascular endothelia. Although Gal-antigen as major antigen was eliminated, the remaining non-Gal antigens are considered to be xenoantigens. Sialosyl-Tn or Hanganutziu-Deicher (HD), are non-Gal antigens specific to natural antibodies in human. To overcome rejection responses such as HAR, studies of genes involved in carbohydrate antigens, causing xenoantigenicity, are necessary. Knowledge of pig glycosyltransferases are also useful to apply to xenoantigen masking or identification of the xenoantigenic sialylglycan(s). In the first chapter the screening for pig glycosyltransferase genes for xenoantigens is presented. In the chapter II to IV the cloning, characterization, and investigation of the regulatory mechanism of the pig CMAH gene in NeuGc biosynthesis is shown. Lastly, the effects of an alteration of pig glycosylation patterns on human serum-mediated cytotoxicity, caused by human sialyltransferases including hST6GalNAc IV is presented.