Search

The second edition of this Handbook provides up-to-date insight into ground-breaking research on international human resource issues today. These issues are faced by multinational companies which can be as small as one person with a computer and Internet connection or as large as a medium-sized country. Written by the field's most distinguished researchers, the book will stimulate thought for new research and provide a glimpse of where we have been and where we are going. The book explores issues such as the importance of linking IHRM activities to organizational strategy and culture; talent management; staffing; performance management; leadership development; diversity management; international assignment and mobility issues; and the role of IHRM in the management of global teams and cross-border joint ventures, mergers and acquisitions. The Handbook illustrates that IHRM research is both theoretically deep and eclectic. Drawing upon a range of paradigms and perspectives this compendium will prove invaluable for HRM scholars, doctoral students, and others interested in IHRM research. Contributors: R.V. Aguilera, A. Bird, I. Bjorkman, J. Bonache, C. Brewster, P. Caligiuri, W.F. Cascio, C.W.S. Chui, D.G. Collings, A. Colvin, O. Darbishire, S.C. Davison, H. De Cieri, J.C. Dencker, J. Dietz, P.J. Dowling, E. Farndale, M. Festing, P.N. Gooderham, M. Harvey, J. Hearn, K. Jonsen, E.P. Kleinlogel, M.B. Lazarova, C. Lengnick-Hall, M.L. Lengnick-Hall, W. Mayrhofer, M. Maznevski, M. Mendenhall, B.D. Metcalfe, M. Moeller, S.S. Morris, J.S. Osland, J. Paauwe, T. Peltonen, R. Piekkari, A. Reichel, R.S. Schuler, H. Scullion, J.B. Sears, S. Snell, P. Sparrow, G.K. Stahl, P. Stiles, L. Stirpe, I. Tarique, D.C. Thomas, S. Tietze, P.M. Wright, B.-J. Zhong

Case studies of 20 successful FDA-approved drugs, from biological rationale to clinical efficacy studies and state-of-the-art applications Chemistry and Pharmacology of Drug Discovery illustrates how chemistry, biology, pharmacokinetics, and a host of disciplines come together to produce successful medicines, discussing a total of 20 drugs that are all FDA-approved post 2021—some of which are first-in-class and revolutionary. The four sections in this book cover Infectious Disease, Cancer Drugs, CNS Drugs, and Miscellaneous Drugs. Each chapter covers background material on the drug class and/or disease indication and key aspects relevant to the discovery of the drug, including structure-activity relationships, pharmacokinetics, drug metabolism, efficacy, and safety. This book is contributed to by various veterans and well-known experts in medical chemistry, many of whom discovered the drugs they reviewed, leading to tremendous quality and depth of insight. Some of the drugs covered in Chemistry and Pharmacology of Drug Discovery include: Nirmatrelvir (Paxlovid with Ritonavir), a 3-chymotrypsin-like protease inhibitor for treating SARS-CoV-2 infectionDoravirine (Pifeltro), a third-generation non-nucleoside reverse transcriptase inhibitor for the treatment of HIV-1 infectionOteseconazole (Vivjoa), a CYP51 inhibitor for treating recurrent vulvovaginal candidiasis, and Rimegepant (Nurtec ODT), a CGRP antagonist for treating migraineCiprofol (Cipepofol), a γ-Aminobutyric acid receptor agonist for induction of anesthesia, and Ozanimod (Zeposia), an S1P receptor antagonist for treating multiple sclerosisDeucravacitinib (Sotyktu), a first-in-class deuterated TYK2 inhibitor for the treatment of plaque psoriasis Chemistry and Pharmacology of Drug Discovery serves as an excellent and highly authoritative learning resource for medicinal, organic, synthetic, and process chemists as well as research scientists in lead optimization and process development.

In the “big data age”, providing informed consent online has never been more challenging. Countless companies collect and share our personal data through devices, apps, and websites, fuelling a growing data economy and the emergence of surveillance capitalism. Few of us have the time to read the associated privacy policies and terms and conditions, and thus are often unaware of how our personal data are being used. This is a problem, as in the last few years, large tech companies have abused our personal data. As privacy self-management, through the mechanism of providing online consent, has become increasingly difficult, some have argued that surveillance capitalism and the data economy more broadly need to be overthrown.This book presents a different perspective. It departs from the concept of revolutionary change to focus on pragmatic, incremental solutions tailored to everyday contexts. It scrutinises how consent is currently sought and provided online and offers suggestions about how online consent practices can be improved upon. These include the possibility of subjecting consent-gathering practices to ethics committees for review; the creation of visual-based consent agreements and privacy policies to help with transparency and engagement; the development of software to protect privacy; and the idea of automated consent functionalities that allow users to bypass the task of reading vast amounts of online consent agreements. The author suggests that these “small-scale” changes to online consent-obtaining procedures could, if successfully implemented, provide us with a way of self-managing our privacy in a way that avoids a revolutionary dismantling of the data economy. In the process, readers are encouraged to rethink the very purpose of providing informed consent online.Rethinking Informed Consent in the Big Data Age will appeal to researchers in normative ethics, applied ethics, philosophy of law, and the philosophy of AI. It will also be of interest to business scholars, communication researchers, students, and those in industry.

The uniqueness of this textbook lies in the fact that, it is the FIRST book in the field of allergy addressing in detail the various diagnostic and therapeutic procedures. The rationale behind presenting this book is to appraise the reader regarding the underlying principles of such procedures and to identify the limitations as well as usefulness in clinical practice. The chapters do include both traditional and modern methodologies representing the global nature of the specialty. Authors have been drawn across the globe to represent the variety of such procedures used in clinical medicine. This textbook will be appealing to medical students, physicians-in-training as well as consultants.

THE authoritative guide for clinical laboratory immunology For nearly 50 years, the Manual of Molecular and Clinical Laboratory Immunology has been the premier resource for laboratories, students, and professionals involved in the clinical and technical details of diagnostic immunology testing. The 9th Edition continues its tradition of providing comprehensive clinical and technical information on the latest technologies used in medical and diagnostic immunology. Led by a world-renowned group of authors and editors, this new edition reflects substantial changes aimed at improving and updating the Manual's utility while reflecting the significant transformations that have occurred since the last edition, including the revolution of gene editing and the widespread adoption of molecularly engineered cellular therapies. Topical highlights include: Laboratory Management: three new chapters cover essential aspects of quality assurance, quality improvement, and quality management, aligning with the increasingly stringent and demanding regulatory environment.Inborn Errors of Immunity: the primary immunodeficiency section has been completely updated to align with the latest International Union of Immunological Societies'classifications of inborn errors of immunity.Functional Cellular Assays: expanded content includes detailed discussions on various functional assays critical for modern immunologic testing.Autoimmune Diseases: expanded chapters on systemic and organ-specific autoimmune disorders, including new chapters on Sjögren's syndrome and deficiency of ADA2, as well as significant updates on organ-specific autoimmune diseases.Transplantation Immunology: updated chapters detail the assessment of immune reconstitution and ABO testing, reflecting latest practices. The 9th Edition of the Manual of Molecular and Clinical Laboratory Immunology serves as an invaluable resource for laboratory directors, clinicians, laboratory managers, technologists, and students. It provides critical insights into the selection, application, and interpretation of immunologic tests, offering practical guidance on troubleshooting, clinical application, and an understanding of test limitations. This comprehensive and up-to-date manual remains an essential tool for anyone involved in the diagnosis, evaluation, and management of immune-mediated and immune system-related disorders.

With its comprehensive, global coverage of all aspects of diagnosis, screening, and treatment in both adults and children, Firestein & Kelley's Textbook of Rheumatology remains your reference of choice in this evolving field. The fully revised 12th Edition retains the user-friendly, full color format, providing in-depth guidance in rheumatology with an ideal balance of basic science and clinical application. New editors, new chapters, and new illustrations keep you fully up to date on recent advances in genetics and the microbiome, current therapies, and other rapid changes in the field. - Covers everything from basic science, immunology, anatomy, and physiology to diagnostic tests, procedures, physical examination, and disease pathogenesis, manifestations and treatment?including key data on outcomes to better inform clinical decision making. - Includes new or significantly revised chapters on Pre-Clinical Autoimmunity; The Microbiome in Health and Disease; Physical Therapy and Rehabilitation; Nutrition and Rheumatic Disease; Classification and Epidemiology of Spondyloarthritis; Etiology and Pathogenesis of Osteoarthritis; COVID and Rheumatic Disease; Vaccination in Rheumatic Disease; Autoimmune Complications of Immune Checkpoint Inhibitors for Cancer; and many more. - Features 1,200 high-quality illustrations, including superb line art, quick-reference tables, and full-color clinical photographs; many new illustrations highlight diseases among racially diverse patients. - Shares the knowledge and expertise of internationally renowned scientists and clinicians, including new editors Drs. Ted Mikuls and Tuhina Neogi. - Demonstrates the complete musculoskeletal exam in online videos, including abnormal findings and the arthroscopic presentation of diseased joints.

O presente Tratado de Coloproctologia, Segunda Edição, reúne a grande experiência de mais de 300 membros da Sociedade Brasileira de Coloproctologia (SBCP) e de alguns colaborado_x0002_res internacionais de renome, atualizando os temas mais importantes desta especialidade. Honrando o passado de uma obra ganhadora do Prêmio Jabuti no Brasil, esta nova edição será importante fonte de estudo e atualização, indispensável tanto para jovens quanto para experientes especialistas em coloproctologia, cirurgia geral e aparelho digestivo.

Der Arzneiverordnungs-Report ist seit 1985 eine gemeinsame Publikation von Autoren aus Pharmakologie, Klinik, Praxis, Gesundheitsökonomie und Krankenversicherung. Basis sind die Verordnungsdaten von Arzneimitteln für ambulante Patienten der gesetzlichen Krankenversicherung (GKV).

Drug Discovery Stories: From Bench to Bedside presents a collection of cases on the development of highly successful pharmaceuticals. It delves into the realm of drug discovery, exploring the structural biology and biological functions of the sought-after targets. The book covers the identification of promising compounds, their transformation from hits to leads through meticulous optimization, and the elucidation of how key compounds interact with the target (in essence, providing invaluable insights for drug design). Additionally, it covers essential information such as the pivotal biological and PK data of lead compounds, any noteworthy clinical results, and a comprehensive overview of other candidate compounds. The field of drug discovery and development has experienced rapid evolution, with numerous new drugs receiving approval each year. While several books have been published on this subject, there is a pressing need for a new book series that accurately reflects the current advancements in drug discovery. This book aims to not only cater to the drug discovery community but also engage other communities involved in chemical biology, synthetic chemistry, and pharmacology. - Analyzes the drug discovery stories of different blockbuster drugs - Includes the newly approved drugs - Covers key aspects related to the drug development of the drugs

This title provides a practically applicable guide to the use of immunomodulators and biologics to treat cutaneous diseases. Chapters cover the mechanisms, applications and safety concerns pertaining to the latest systemic therapies. Extensive guidance is provided on how to design lab monitoring schedules, manage patient follow-up visits, develop tapering plans and assess adverse outcomes. The book also reviews how to initiate off-label applications and establish methods of matching mechanisms for a range of diseases to the mechanisms of the available therapies. The latest updates in the development and utility of systemic immunomodulators, biologics and JAK Inhibitors from clinical trials and updated guidelines are also discussed. Immunomodulators and Biologics in Dermatologic Treatment comprehensively describes the use of a range of systemic therapies for immunomodulation in dermatology and how best to incorporate these into practice. It therefore represents a valuable resource for novice readers and experienced dermatologists involved in the management of these patients.

The latest edition of the world's leading dermatology textbook Rook's Textbook of Dermatology, 10th Edition is the most definitive, comprehensive and illustrated reference work in dermatology worldwide. Fully updated by experts from around the world, the book highlights the latest key evidence-based developments in pathogenesis, diagnosis and treatment of skin disorders. A highly intuitive resource and invaluable clinical companion for both those training and those fully qualified in dermatology, other highlights of Rook's Textbook of Dermatology, 10th Edition include: 1. Comprehensive review of essential basic science, skin biology and pharmacology 2. More than 3000 clinical illustrations 3. Histological images to aid clinicopathological correlation 4. Up-to-date management details for all major dermatological disorders including emerging infections 5. All chapters fully referenced together with highlighted key references 6. Quick reference to essential facts, treatment ladders and management algorithms 7. Chapter dedicated to global skin health and inequalities 8. Description of the spectrum of presentations in dermatoses in skin of colour 9. Thorough review of surgical and aesthetic dermatology 10. On-line videos of practical procedures Rook's Textbook of Dermatology, 10th Edition is universally recognised as the most complete reference work for dermatologists of all experience levels and dermatology students worldwide.

This manual describes the issues of diagnosing and managing skin diseases relevant to primary care, where the vast majority of dermatology patients are initially investigated. In most circumstances, primary care physicians need to assess and diagnose skin conditions without the aid of any laboratory or other diagnostic tests. Given that dermatological training for primary care providers is limited, this can make it challenging to diagnose skin diseases accurately, more so for those in the early stages of their career. The Manual of Primary Care Dermatology is written by a dermatologically trained practicing primary care physician to address the issues in managing skin diseases in primary care medicine. It provides readers with practical guidance on the differential diagnosis of skin diseases. The anatomical approach presented makes it easy for the reader to manage their patients'skin condition. With chapters dedicated to lesions of the scalp, face or upper extremity, it represents a quick reference book even for a busy practitioner. It is therefore essential reading for all primary care physicians and dermatologists looking for a compact reference to the differential diagnosis of all skin diseases.

This book covers contemporary essays by opinion leaders on crucial topics in dermatology that are not readily available in other textbooks and journals. The essays are written in an unconventional style compared to other textbook styles. Each chapter is authored by a globally renowned expert in that field.The book focuses on artificial intelligence in dermatology, placebo and nocebo in dermatology, mind and skin diseases, unconventional/holistic views on skin aging, evidence-informed dermatology, procedural dermatology, investigative dermatology, lasers and light sources in dermatology, skin in rheumatologic diseases, immunology of the skin, live imaging techniques in dermatology, and so on. The book will help specialists look at the subject from an entirely different perspective and understand how dermatology is evolving in the 21st century. A wide range of dermatology topics is covered, providing a snapshot of contemporary dermatology and the dermatology of the future. It promises to be a delightful journey from basic science to translational science to clinical science. This book will be Intellectually stimulating for dermatology trainees, practitioners, and academicians.

This new edition builds upon the foundational knowledge covered in the first edition, covering the epidemiology, pathogenesis, and clinical presentation of atopic dermatitis in both pediatric and adult patients. It provides an overview of the mechanism and presentation of atopic dermatitis and focuses on the management methods experienced dermatologists have used to successfully manage atopic dermatitis. The book includes new chapters describing the special considerations for atopic dermatitis in skin of color patients, dedicated chapters on topical and oral prescription management reflected the latest FDA-approved treatments, and also a chapter covering the updated guidelines from the American Academy of Dermatology. A final chapter includes updates on the future of atopic dermatitis treatment. This book provides physicians with insights into the management of atopic dermatitis, such as alternative treatments for pruritus, psychosocial impact on patients and families,assessing patient compliance, and patient resources.

Encyclopedia of Food Allergy, organized in 10 sections, with ~200 chapters, and written by world-renowned clinician-scientist authors, is the most comprehensive resource for food allergy ever compiled. With online and physical presence, intuitive and easily accessible organization of information, the reader can quickly access overview and general topics as well as detailed information to inform solutions to clinical or research questions. Research topics provide the necessary background for the novice as well as the details required for those in the field. Clinical topics provide comprehensive and practical information, with generous use of tables, figures, and key points/clinical pearls, to inform clinical decision-making, and promote evidence-based management decisions. Food allergy may affect up to 10% of the population in developed countries and appears to be increasing in prevalence worldwide, with many food allergies proving life-long, severe and potentially fatal. The last decade has witnessed a sea change response to the impact of food allergy through basic science research on the immunology, food science research on the triggers, clinical approaches to daily management, treatment and prevention, and an increasing understanding of the psychosocial and societal implications and how to address them. With the expanding breadth and depth of the field, there is no existing comprehensive resource available for those professionals interested in learning about or contributing to food allergy research and clinical care. This is a complete resource covering broad and detailed aspects of food allergy and adverse food reactions for clinicians, researchers, regulators, food industry, students and other stakeholders who need and will benefit from a rich resource with in-depth and practical information. - Presents in-depth, comprehensive coverage from an outstanding international author base of domain experts - Ideal for new researchers and clinicians who will have a single resource that includes general topics to get them started - Includes access to detailed information in their areas of work AND for many related topics that will help improve their research or clinical care

This book presents 15 cases as studies in how to reach a diagnosis from a presenting patient. It covers 15 major topics in clinical dermatology as a succinct reference for dermatology clinicians in practice, also offering a concise revision guide for those in training, from medical students and resident physicians preparing for higher examinations to established physicians in their continuing professional development. Covers essential points in clinical dermatology for practice and training or revision and review for boards or certification. Presents a succinct resource for dermatologists, family physicians, and other professionals with an interest in problems of the skin, nails, and hair. Offers a one-stop guide to 15 core topics.

This concise practical guide is designed to facilitate the clinical decision-making process in the management of atopic dermatitis by reviewing a number of cases and defining the various diagnostic and management decisions open to clinicians. It is well illustrated and diverse in scope, enabling the reader to obtain relevant information regarding both standard and unusual cases in a rapid, easy to digest format. Each case includes a narrative description and patient management tips along with a relevant board review question. This book covers exciting updates in the diagnosis and management of AD such atopic dermatitis spectrum disorder and the effects of internal vessel inflammation in AD patients. It also highlights the newest oral, biologic and topical therapies (along with pipeline therapies) in the treatment of atopic dermatitis. Clinical Cases in Atopic Dermatitis is a must-have resource for dermatologists, dermatology residents, fellows, medical students, nurse practitioners and physician assistants, as well as allergists and immunologists.

Preserving good skin condition has significant quality of life implications for diabetic patients, especially for those suffering from related ulcers or diabetic foot syndrome. This timely work on the cutaneous manifestations of diabetes offers an interdisciplinary approach to help the practitioner's differential diagnosis and choice of the best therapeutic options. Starting from the broader picture to focus successively on infections of the skin, problems resulting from reduced circulation, leg ulcers, it also includes parts on wound and skin care. Chapter topics include complications and imaging, dermatoses and (auto) inflammatory skin diseases. Richly illustrated and presented in a clear style, Cutaneous Manifestations in the Diabetic Patient is meant for clinical dermatologists, general practitioners, internal medicine practitioners but will be a valued companion to nursing personnel and health care professionals involved in the care of diabetic patients, enabling early detection and safe management.

This volume aims at delivering the state-of-the-art scientific and clinical know-how for the management of patients with Connective Tissue Diseases (CTDs). With contributions from leading specialists from different disciplines, it presents the latest research findings on many aspects of the diseases in a clear, comprehensive way, and describes the most recent trends in treatment, such as the “treat to target” approach. Both basic science and clinical medicine are addressed, with emphasis on the most promising clinical and laboratory-based studies. The coverage is comprehensive in scope, and includes epidemiology, pathogenesis, autoantibodies and biomarkers, disease manifestations, involvement of different organs or systems, the relationships with other disorders, and biological therapy. Readers will find this second volume to be an excellent source of information on the current understanding of CTDs, and clinical approach to CTD, clearly conveying the progress made in recent years. Connective Tissue Disease – A Comprehensive Guide Vol.2 will be an invaluable source of up-to-date information for all practitioners involved in the care of patients with these complex diseases.

Allergies and allergic diseases can indeed affect multiple organs and systems in the body, leading to a wide range of symptoms and manifestations. By compiling insights from experts in different specialties, this book aims to support the medical literature and contribute to the collective knowledge on allergies. Although the causes and pathogenesis of allergic diseases in general are as described, this book is designed to be a guiding project by considering allergic diseases one by one and their causes, pathogenesis differences, and current treatments. Current Approaches to Allergic Diseases serves as a valuable resource for healthcare professionals, researchers, and students interested in allergies and allergic diseases, offering a comprehensive overview of current knowledge and future directions in this important area of medicine.

Schachner and Hansen's Pediatric Dermatology has been the gold-standard reference in pediatric dermatology for more than 33 years. The new edition is a comprehensive textbook covering all the skin conditions of children and adolescents in a two-volume masterwork that will meet the expectations of pediatric dermatologists, dermatologists, pediatricians and all who provide pediatric healthcare.

Natural Products for Treatment of Skin and Soft Tissue Disorders presents a simple and straightforward exploration of the role medicinal plants play in treating a diverse range of skin-related disorders. With contributions from researchers worldwide, this book delves into the pathology of skin conditions such as eczema, superficial mycoses, acne, vitiligo, and skin ulcers, providing effective treatment protocols using natural remedies. It also addresses prevalent disorders like atopic dermatitis and skin infections in developing countries. Finally, the book sheds light on the rising concern of skin cancer and potential natural therapeutic approaches. Readers will be equipped with the knowledge to harness the power of natural medicines in their dermatology practice.This comprehensive resource serves as a handbook for medical residents, students and dermatologists, offering invaluable insights into the potential of medicinal plants for the treatment of skin and soft tissue disorders.

This book explores the latest developments in health and disease research, including new research on SARS-CoV-2, the role of cytokines in asthma, the Omicron variant, mitogen-activated protein kinases as a target for regulating connective tissue growth, deep-learning-based risk assessment of dementia, novel strategies for managing Diabetes Mellitus, hospital management and game theory, available screening methods for the diagnosis of adrenal cortical insufficiency in developing countries, and chiari malformations in children.

In this extensively revised fourth edition textbook, authors Vladimir Pucik, Ingmar Björkman, Paul Evans and Günter Stahl take a people management and organizational perspective on the complex issues involved in successfully managing today's multinational firms. Taking account of contemporary business challenges of digitalization, inclusion, and sustainability, The Global Challenge explores how international strategies are executed through people management. Key Features:Practical examples from leading and emerging multinational firms from around the worldConnected yet self-contained chapters to be used as teaching material in courses and programsCritical insights provided by a team of scholars with extensive teaching, research, and consulting experience worldwideFocus on topical issues such as mechanisms of cross-border control and coordination, virtual work and collaboration, diversity and inclusion, management of knowledge and innovation, and the role of people management in tackling societal problems and global sustainability challenges Balancing thoroughly updated case studies with the latest academic research, this cutting-edge fourth edition textbook will be an invaluable resource for students enrolled in MBA, EMBA, and Master's programs worldwide. Executives, managers, and HR professionals in multinational companies will also benefit from its examination of challenges and contradictions that firms confront when operating across borders.

Antimicrobial Peptides: Challenges and Future Perspectives covers the latest developments about antimicrobial peptides in the scenario of drug resistance. The book is divided into 16 chapters arranged in sequence and preceded by chapters on historical developments and their role as regulatory molecules in innate defense mechanism. Emphasis is given to purification techniques and characterization suitable for interdisciplinary research. Chapters provide an inventory of various antimicrobial peptides, from a diverse array of organisms such as bacteria, fungi, insects, amphibians, plants and mammals. A section on marine ecosystem broadens readers understanding on marine based antimicrobial peptides. Additional sections provide an informative overview on peptides with antiviral properties and those targeting multi-drug resistant bacteria. Recent reports and mechanism on resistance against antimicrobial peptides are also provided, along with key insights into the challenges and future perspectives of peptide drug development. - Emphasizes antimicrobial peptides targeting various human viruses and multidrug resistant bacteria - Written by internationally recognized experts who provide readers with a wide and useful perspective - Provides in-depth resources for undertaking a research work in antimicrobial peptides with the inclusion of chapters on purification techniques and structural details - Addresses the possibility and availability of peptide antibiotics in the global drug market - Serves as a complete resource from the discovery to drug development of peptide antibiotics

This book appraises the role of lipid-based drug delivery systems (LBDDSs) with respect to the bioavailability and controlled delivery of complex drug molecules for improving their clinical viability. It covers the latest developments and advancements in the field of drug delivery, and explores and compiles information on the current situation of lipid-based formulations used as versatile excipients and all their possible routes to improve therapeutic benefits. The book discusses novel formulations such as depot formulations, micro- and nanoemulsions, solid lipid nanoparticles (SLNs), nanostructured lipid carriers (NLCs), liposomes, nanoliposomes, micelles, nanosuspensions, lipid implants and inserts, and lipid nanotubes. It presents preparation methods of LBDDSs and their physicochemical properties, and portrays their various application angles and their impacts on drug-conveyance frameworks when employed in vitro and in vivo. The book is beneficial for researchers working on lipid-based drug formulations as well as biological and translational drug delivery. It is also a useful resource for course work of students of various academic degree programs such as pharmacy, health sciences, biotechnology, and microbiology; postgraduate and PhD students; and postdoctoral fellows researching on nanomedicine-based drug delivery systems.

CHEMISTRY AND BIOLOGICAL ACTIVITIES OF IVERMECTIN The book focuses on the biological activities of ivermectin as well as the significant global utility of IVM since it was first used about 35 years ago. Ivermectin (IVM) is a “wonder drug” containing a 16-membered macrocyclic lactone ring system in its structure and derived from the family of avermectins. It was isolated by the fermentation of the soil microorganism Streptomyces avermitilis by Satoshi Omura in 1960 and studied by William C. Campbell in 1981, which allowed for its treatment of onchocerciasis (River Blindness) in Africa. Both scientists subsequently received the 2015 Nobel Prize in Physiology or Medicine. It was approved by the FDA in 1997 for the treatment of Strongyloidiasis and crusted scabies in AIDS patients. After that, IVM has attracted the tremendous attention of the scientific community and has been used for diverse purposes, including as an inhibitor of the causative virus (SARS-CoV-2). The chief purpose of this volume is to focus on the chemistry and biological activities of ivermectin. The chapters have been arranged in a systematic manner, starting from the historical background and synthesis of IVM to the pharmacological and environmental aspects, followed by diverse applications. Although the usage of ivermectin for the treatment of COVID-19 remains under investigation and controversial, one of the chapters is dedicated to its use. The anti-parasitic, anti-malarial, anti-cancer, and anti-inflammatory activities of IVM are discussed in detail. The anthelminthic and insecticidal roles of IVM are briefly described and there are several cases of IVM in dermatology. Audience Researchers, scientists, and postgraduate students working in the fields of organic synthesis, medicinal chemistry, medical science, pharmacy, biotechnology and biomedical sciences.

Dermatological diseases are extremely common around the globe, and a systematic understanding of these conditions and their relationships with various epidemiological factors could provide insights to help governments and private institutions address the challenges they need to overcome in order to improve global health. This extensively revised second edition comprehensively discusses the fundamental areas of dermatological practice in public health. It features more than 900 figures, eight new chapters and two new sections: a) Dermatological Biopsy and Major Histopathological Patterns, exploring surgical methods for collecting cutaneous specimens from outpatients and the analysis of major histopathological patterns; b) Special Chapters, which outlines Hospital Dermatology in Public Health, covering hospital care as a backup in dermatoses of importance in public health; Dermatological Education in Public Health, examining the interface between teaching and students for the development of dermatological practice; and a Brief History of Dermatology.Further topics include the profile of dermatological care based on epidemiological concepts; the most significant skin diseases (including dermatology in tropical medicine); the relationship between the environment and dermatological diseases; dermatoses in the human life cycles, diseases that are not primarily dermatological, but have a high impact on public health and may have skin and mucosal manifestations; a number of emerging issues in dermatology in public health; clinical approaches (diagnosis and management) to common dermatological symptoms; multidisciplinary approaches in dermatology; surgical and histopathological aspects of the main dermatological diseases; and the hospital as an aid in the management of complex dermatoses and dermatological education in public health. Written by experts with extensive experience in their respective fields, this book is a valuable reference resource for undergraduate and graduate students, dermatologists and general practitioners, as well as anyone interested in the relationship between dermatology and public health.

This book reviews the relationship between cytokines, glia, and neurons in the pathophysiology of neuropsychiatric disorders and examines the mechanisms of action of the drugs used for the treatment of these disorders. Increasing evidence has suggested that glia perform important roles in various brain functions, but much remains to be learned about these crucial cells and their interplay with neurons. In addition, a better understanding of the interaction between inflammatory mediators, such as cytokines, and the activated immune response will be of critical importance for the development of new therapeutic strategies. These key areas are the focus of this book, which documents the latest research findings in the field. Evidence is provided for the role of inflammation-induced toxic metabolites from the tryptophan pathway in a wide range of neuropsychiatric disorders, including depression, schizophrenia, and Alzheimer's disease. In presenting state of the art knowledge on the interactions between cytokines, glia, and neurons, the book will help to pave the way for the development of novel targets for the prevention and treatment of neuropsychiatric disorders.

Der Arzneiverordnungs-Report ist seit 1985 eine gemeinsame Publikation von Autoren aus Pharmakologie, Klinik, Praxis, Gesundheitsökonomie und Krankenversicherung. Basis sind die Verordnungsdaten von Arzneimitteln für ambulante Patienten der gesetzlichen Krankenversicherung (GKV).

Pediatric Primary Care: Practice Guidelines for Nurses, Fifth Edition is a comprehensive resource for well-child management and acute care management of childhood illnesses in a primary care setting. Written by practicing experts, this text is intended for advanced practice nursing students as a quick reference guide once they enter clinical practice. To manage initial and follow-up visits, the Fifth Edition features templates for gathering first visit history, as well as a template to record new information since the last visit. Instructions for gathering medical history information are also included.

With examinations of 19 new psychiatric drugs, 19 new forms of previously available drugs, and a host of new medical agents, this third edition of the Clinical Manual of Psychopharmacology in the Medically Ill has been updated to include medical and psychiatric drugs that have become available since the publication of the second edition in 2017, as well as recent relevant randomized controlled trials, systematic reviews, and meta-analyses. Boasting all the rigor that characterized the preceding editions, every chapter in this new volume has been reviewed and revised by experts—including 11 new authors. For 15 categories of medical disorders and specialty areas that include cardiovascular disorders, oncology, obstetrics and gynecology, and substance use disorders, the book examines • Key differential diagnostic considerations • The evidence for the efficacy of psychiatric drugs in each disorder • Disease-specific side effects of psychiatric drugs • Neuropsychiatric side effects of drugs for each medical disorder • Disease-specific alterations in pharmacokinetics • Drug-drug interactions Patients with medical and psychiatric comorbidity have more functional impairment, disability days, emergency department use, and rehospitalization, as well as higher medical care costs. By examining the intersection of psychiatric and medical illness, and offering easily referenced key points for each chapter, this new edition prepares both mental health practitioners and primary care physicians and internists to more safely and effectively work with patients who have psychiatric and medical illness.

This book, Psoriasis—A Closer Look (Second Edition), is designed as an academic project with the target readers as both postgraduate students and practicing dermatologists. All chapters encompass glimpses of existing knowledge in the light of recent advances in the segment of “Psoriasis”, complications, and the comorbidities. The treatment challenges, both oral and systemic, have been addressed in this edition. Yet another unique addition is the chapter on “Dermoscopy”.

The latest edition of this essential text provides a comprehensive overview of the unique pediatric issues of inflammatory bowel disease. Through new and thoroughly revised chapters, the volume features updates on all aspects of etiology, diagnosis, and treatment, with an emphasis on recent understanding of pharmacokinetics and the utilization of cutting edge therapeutic monitoring to maximize efficacy of medical management. The new edition also highlights newer, recently approved drugs, emerging therapies, and the most recent recommendations regarding post-operative management for patients who ultimately require surgery. Written by experts in the field, Pediatric Inflammatory Bowel Disease, Fourth Edition is a valuable resource for both pediatric and adult gastroenterologists involved in the care of children with inflammatory bowel disease.

Since the first cases of an acute respiratory illness were reported, the pathogen SARS-coV-2 (severe acute respiratory syndrome coronavirus 2) and its disease, COVID-19 have disrupted the world and changed the course of medical history. Clinics were under lockdown and supplies of critical drugs such as biologics and meladinine were delayed. The prolonged impact of disease has taken its toll on patients, their careers, medical staff, research and medical education. Shortly after the first landmark studies of COVID-19 vaccine trial data were made known, global mass vaccination programs were underway. Vaccine technology has expanded beyond messenger RNA (mRNA) to include non-replicating viral vectors, inactivated virus, and protein subunits. Cutaneous manifestations of vaccine reactions, including non-mRNA and their morphological patterns, indications and contraindications, vaccine global access, equity, allocation of booster doses, emerging COVID variants and subvariants, waning vaccine and treatment efficacy are the issues that begged to be explored. New oral therapies are available for treatment of COVID-19 but they bring with them drug-drug interactions and potential side effects.This book is a compilation of a concerted effort by dermatologists across the globe to join hands against COVID-19. Each chapter has been written by experts in the field, with first-hand experience and synthesized literature to offer the most up-to-date coverage in the fast-paced, changing landscape of COVID-19 in dermatology. COVID-19 in Dermatology is a valuable resource for dermatologists, dermatology residents and medical students, and general practitioners.

Atopic dermatitis (eczema) is one of the most common and most challenging skin conditions, for patients and practitioners alike. Uniquely organized by intrinsic and extrinsic etiologies, Atopic Dermatitis: Inside Out or Outside In? examines a myriad of causes that start from both the inside of the body and from the external environment, offering physicians practical ways to design treatments that specifically address these causes. Drs. Lawrence S. Chan and Vivian Y. Shi, along with a team of expert contributing authors, examine the etiology of this complex disorder and provide targeted, comprehensive solutions and the most useful therapeutic plans based on pathophysiology, including evidence-based integrative management. - Analyzes the pathophysiology of atopic dermatitis from two distinct fronts: inside out and outside in—an approach that is unique in the field. - Begins with an overview of the disease, then delves into both internal and external pathogenic factors, followed by the Clinician's Corner, which offers practical recommendations for treatment. - Organizes therapeutic discussions by corresponding pathophysiology rather than a one-size-fits-all approach. - Covers recently FDA-approved and emerging medications, as well as atopic comorbidities.

Within the past twenty years, facial soft-tissue augmentation with dermal filler products have become extremely popular. These products are usually considered safe, having mostly mild and transient adverse effects. However, serious complications related to injection injuries to relevant anatomic structures, such as nerves and vessels, can occur even in the hands of experienced injectors. The author was one of the first doctors in the world to reverse these changes by establishing a hyaluronidase protocol in 2005. Since then, he has developed both the award-winning HELPIR and PLUS procedures to heal this damaged tissue. Complications associated with injections arise in most cases from injector inexperience or the use of unapproved products. In this book, the author reviews almost a hundred interesting aesthetic cases that have been referred to him from all over the world and he gives his methods of dealing with these complications. It also includes his methods of using botulinum toxin to treat blepharospasm, trigeminal neuralgia, migraine, and blushing. This text provides an invaluable source of information for any medical personnel looking for a career in aesthetic medicine.

This entirely revised edition of the successful work presents the state of the art in clinics, research and practical management of atopic dermatitis - eczema. The wide variability in clinical morphology including differences between age groups and ethnicities is illustrated by color pictures including the typical minimal manifestations or “stigmata” suggestive of atopy. The dramatic rise in the prevalence of this disease over the last few decades is reflected by detailed analyses of epidemiological data from all over the world. In-depth descriptions of key pathophysiological mechanisms including epidermal barrier, molecular genetics, itch pathophysiology and modern cellular immunology offer readers a deeper understanding of the complex events leading to the often excruciating symptoms. Treatment – and management – comprises all aspects from elicitor avoidance to basic emollient skin care, immuno-modulating treatments both topical and systemic, up to the latest advances in kinase inhibitors and biologics.In turn, the book discusses the role of the microbiome and antimicrobial treatments as well as phototherapy, provides dietary recommendations for individuals with food allergies, and explores psychosocial aspects of the disease. Environmental influences are considered with regard to irritants and allergens. All recommendations are based on current national and international guidelines. The complex management strategies for this disease have led to the emergence of educational programs (Eczema Schools), which the authors have developed and promoted at the national and international level. This new revised edition of Atopic Dermatitis - Eczema will be an invaluable asset for dermatologists, allergists, pediatricians and general practitioners, but also for all related health personnel and patient organizations interested in gaining a fuller understanding of this widespread skin disease.

Seit dem Erscheinen der 1. Auflage dieses Lehrbuches zur Neurodermitis sind beträchtliche Fortschritte hinsichtlich der Erforschung der Krankheitsentstehung und der Entwicklung neuer Therapien erzielt worden. Die mittlerweile vorliegende 4. Auflage berücksichtigt diesen Progress und widmet sich bei der Vermittlung des komplexen therapeutischen Vorgehens neben den verschiedenen bisherigen Optionen auch neuen Medikamenten zur systemischen Therapie. Die Auswahl der Themen und deren Gewichtung in diesem Buch beruht dabei u.a. auf den langjährigen Erfahrungen aus Neurodermitisschulungen. Auch den psychosozialen Komponenten der Krankheitsbewältigung und -anpassung sowie der Edukation der Betroffenen wird ein entsprechender Stellenwert beigemessen. Dieses Buch ist erneut ein bewährter Leitfaden für Patienten und Ärzte gleichermaßen, der alle wichtigen Facetten der Erkrankung darstellt und vertieft.

All the chapters have been written by authors who are experts in their relevant areas of interest. This endeavor hopes to present to the Indian Association of Dermatologists, Venereologists and Leprologists (IADVL) members, recent high-quality publications and literature in a concise and an easy readable format.

This book identifies the broad scope of dermatological conditions in patients with scalp disorders. Scalp disorders can be associated with various conditions such as inflammatory, neoplastic and systemic diseases. Patient history and physical examination significantly narrow the differential diagnosis, but in doubtful cases trichoscopy or scalp biopsy is needed to establish correct diagnosis. Treatment of scalp diseases varies from topical through intralesional to systemic options, dependent from type and severity of the disease as well as coexisted conditions. Clinical cases are the key component in modern medical education, assisting the trainee or recertifying clinician to work through unusual cases using best practice techniques. Clinical Cases in Scalp Disorders illustrates clinical features and discuss diagnostic and therapeutic process of both common and unusual conditions. It provides a practical case-based guide in the management of patientswith scalp diseases and is ideal for both board-certified dermatologists and dermatologists in training.

This book covers all aspects of hypersensitivity to drugs, providing practical information for non-specialist physicians as well as addressing issues of interest to practitioners in different specialties and presenting the expert knowledge required by specialist allergists and immunologists. The opening, general section discusses basics such as clinical manifestations, histopathology, mechanisms, risk factors, drug hypersensitivity in particular populations, and the full range of diagnostic methods. The second part of the book provides concise information on the most important drug classes and guides the reader on how to proceed when patients present with a suspected reaction. For each drug class, the current level of evidence for use of the different diagnostic tools, including skin tests, provocation tests, and in vitro tests, is clarified, and management options, outlined. The inclusion of helpful tables and algorithms is designed to aid in decision making. Drug hypersensitivityis among the more complex allergological issues, and this book will meet the needs of general practitioners, internists, and specialists.

Biologic therapy is a treatment that strives to modulate a patient's immune system to fight a given disease. In psoriasis, a skin disorder that is partly caused by a dysregulated immune system resulting in well-demarcated red areas of the skin with white scales, biologic therapy has the potential to vastly improve upon patient outcomes by minimizing the symptoms of this disease while maximizing the safety profile of the therapy. This book offers an up-to-date and comprehensive review on biologic therapy for the treatment of psoriasis. With over 10 FDA approved biologic agents for psoriasis (with more in the pipeline), confusion exists among providers regarding which agent is best for a particular patient. Chapters cover all FDA approved psoriasis biologic agents (including pipeline agents) for use in pediatric, adult, and geriatric patients. This book is unique in that it will not only cover cutting edge treatment principles based on the latest research, it will also be one of the most comprehensive reviews of psoriasis biologics in the COVID-19 era. Biologic Therapy for Psoriasis is a must-have resource for board certified dermatologists and rheumatologists, dermatology and rheumatology residents and fellows, dermatology physician assistants, nurse practitioners and medical students. The ultimate goal of this book is to improve patient care by making the busy practicing dermatology provider more adept with these particular therapies.

Allergies are a significant health issue, yet few books exist on allergen tolerance of separation; here the author classifies allergen tolerance breakdown in specific types, according to the possibility that the autonomic breakdown of allergen tolerance in the unified airway depends on a deficit of pro-tolerogenic neurotransmitters at the local level. This paradigm, which explains the pathogenesis of allergic disorders, opens to new approaches to allergen-specific immunotherapy (AIT). While focusing on the new atopic disorders of the unified airway, such as local allergic rhinitis,'dual'allergic rhinitis, local allergic asthma, and local allergic conjunctivitis, the work combines clinical examples of allergic diseases and their treatment with their immunological background. The topics range from the specific immune-derived maintenance of allergen tolerance and the role of the neuroimmune network in allergic inflammation to conventional atopic diseases and more particular issues of local atopic disorders in the unified airway, oral tolerance, and its breakdown, and its translation in genitourinary aspects of allergic inflammation. Specific chapters are also devoted to allergen-specific immunotherapy (AIT) and anti-allergy treatments. Thought for upper graduate students, it will also be a valued resource for allergy practitioners, pulmonologists, ENT specialists, pediatricians, and translational researchers. Textbook of Allergen Tolerance includes classical didactic features such as abstracts, keywords, background notes, discussion points, and Q&A., as well as 20 audio files Text-to-Speech for the visually impaired, and 10 video to support the readers.

••Selected for Doody's Core Titles® 2024 in Allergy/Clinical Immunology•• Allergic and Immunologic Diseases: A Practical Guide to the Evaluation, Diagnosis and Management of Allergic and Immunologic Diseases is a valuable resource for researchers and others involved in the day-to-day practice of allergy and immunology, with specific information, protocols and algorithms to guide their thinking. The book provides practical information and an explanation of why and how we do things, while also addressing the limitations of testing and treatment. Other sections focus on scientific based practices and the known pathophysiology of allergic and immunologic diseases, along with mechanisms of action in various treatment modalities. This book is unique in that it explains the rationale behind everything we do in allergy and immunology, hence it offers readers specific information on procedures and how to order tests and treat allergic and immunologic diseases. - Contains useful information on allergic and immunologic diseases, from why we do things the way we do, to methodologies, interpretation of the results and management of diseases - Provides information that can be immediately downloadable for any specific procedure or treatment algorithm for immediate use - Evaluates scientific merit and evidence or lack thereof

Comprehensive Pharmacology, Seven Volume Set is organized into twelve sections that explore therapeutic areas, with a total of 320 comprehensive articles and 6,800 pages of important findings. Sections contain highly detailed coverage of information that has been overseen by an editorial board made up of well-respected, field leading experts. The content in this book offers readers an in-depth and easily accessible reference work on every aspect of pharmacological research surrounding the pharmacology of all therapeutic applications of drugs, their mechanism of action and their therapeutic values. These elements are essential as drugs are almost never tested and developed in the actual therapeutic system, but rather in test systems from which parameters must be determined to predict activity in systems of varying ambient physiology. As different technologies rapidly evolve, there is an ever-increasing level of knowledge about the pharmacology of known drugs, along with increasing capability to utilize pharmacological systems to predict new drug activity, all of which must be communicated to professionals in varying fields. - Contains chapters that follow a consistent and templated approach, resulting in well-structured content that enhances user experience and appeal - Offers a comprehensive review on a wealth of information on pharmacology and how it utilizes concepts and techniques from a broad array of sciences, ranging from chemistry to physiology to medicine - Includes a wider use of color and multimedia content, with interactive features, links, computational modeling and animations to illustrate the effects of toxic substances in various contexts

Encyclopedia of Infection and Immunity, Four Volume Set provides new insights into the interactions between bacteria, fungi, parasites and their hosts. Specific areas of interest include host cellular and immune response to microbes, molecular mechanisms of action of beneficial microbes or host-associated microbial communities, microbial pathogenesis, virulence factors, experimental models of infection, host resistance or susceptibility, and the generation of innate and adaptive immune responses. Comprised of over 200 chapters written and edited by leading experts in the field, this book will serve as a key resource for students, researchers, academics and industry practitioners in the fields of microbiology, immunology, and infectious diseases. More than 100 years after Robert Koch and Louis Pasteur established the microbial etiology of communicable diseases, the field of microbiology is experiencing a second period of rapid growth and expansion, driven by the realization that changes in host-associated microbial communities might be at the root of a broad spectrum of noncommunicable human diseases. These advances follow on the heels of recent progress in high-throughput sequencing technology, which has provided a wealth of information on the human microbiome and its physiological potential. - 2023 PROSE Awards - Winner: Finalist: Reference Works – Biological and Life Sciences: Association of American Publishers - Offers a contemporary review of current infection and immunity research, and insights into the future direction of the field - Meticulously researched and cross-referenced to allow students, researchers and professionals to find relevant information quickly and easily - Includes chapters written by academics and practitioners from various fields and regions, ensuring that the knowledge within is easily understood by, and applicable to, a large audience

This book identifies the broad scope of dermatological conditions in patients with hair and scalp disorders, with particular focus on the hair. These disorders can be associated with various conditions, such as inflammatory, neoplastic and systemic diseases. Often patient history and physical examination significantly narrow the differential diagnosis, but in doubtful cases, trichoscopy or scalp biopsy is needed to establish correct diagnosis. Treatment of hair disease varies from topical through intralesional to systemic options, dependent from type and severity of the disease as well as coexisted conditions. Clinical Cases in Hair Disorders illustrates clinical features and discuss diagnostic and therapeutic process of both common and unusual conditions. It provides a practical case-based guide in the management of patients with hair diseases and is ideal for both board-certified dermatologists and dermatologists in training.

A great deal of knowledge about eosinophilic lung diseases has been gained in the last few years, but unanswered questions concerning eosinophil biology still remain. It is in this context that this Monograph was developed. Broad in scope, the book bases its approach to the management of eosinophilic lung diseases on a fundamental understanding of eosinophil biology in health and disease. State-of-the-art reviews written by world-leading authorities and up-and-coming stars in the field take the reader on a journey through the different eosinophilic lung diseases. This Monograph will ensure the practicing clinician is better equipped to recognise and treat patients with eosinophilia, as well as appreciate the advances coming in the near future.

This book aims to approach the epidemiology, diagnosis and management of infectious complications related to the use of biologic and targeted therapies. The first part is a general overview on the epidemiology and prevention of infections with the use of these agents. Timelines, pre-treatment evaluation, use of vaccines and travel counseling. In the second part, we will analyze the specific risk of infections associated with the use of the most important agents. The third part approach the problem on a syndromic point of view. For example, how to evaluate pulmonary infiltrates in a patient receiving biologic agents. This part III includes the most difficult and conflicting syndromes that clinicians may face when evaluating these patients.This book is intended not only for infectious diseases specialists, but also for different medical specialties prescribing biologic and targeted therapies.