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Giant vesicles are widely used as a model membrane system, both for basic biological systems and for their promising applications in the development of smart materials and cell mimetics, as well as in driving new technologies in synthetic biology and for the cosmetics and pharmaceutical industry. The reader is guided to use giant vesicles, from the formation of simple membrane platforms to advanced membrane and cell system models. It also includes fundamentals for understanding lipid or polymer membrane structure, properties and behavior. Every chapter includes ideas for further applications and discussions on the implications of the observed phenomena towards understanding membrane-related processes. The Giant Vesicle Book is meant to be a road companion, a trusted guide for those making their first steps in this field as well as a source of information required by experts.Key Features• A complete summary of the field, covering fundamental concepts, practical methods, core theory, and the most promising applications• A start-up package of theoretical and experimental information for newcomers in the field • Extensive protocols for establishing the required preparations and assays• Tips and instructions for carefully performing and interpreting measurements with giant vesicles or for observing them, including pitfalls• Approaches developed for investigating giant vesicles as well as brief overviews of previous studies implementing the described techniques• Handy tables with data and structures for ready reference

This book presents and explains the latest developments in surgery for congenital digestive tract malformations, tumors, abdominal trauma, and the most important acquired digestive disorders. Particular attention is paid to minimally invasive and innovative techniques. In addition to clear descriptions of the surgical procedures that highlight useful tips and tricks, for each condition the clinical presentation is well illustrated and information is provided on pathogenesis. The book also includes general chapters that address the anatomy of the abdomen in children, diagnostic issues, the problem of clinical nutrition, and other aspects of management in pediatric patients with gastrointestinal pathologies. Pediatric Digestive Surgery will serve as a comprehensive and up-to-date reference for all pediatric surgeons. It will provide the trainee with easily understood, concise guidance while offering the more experienced surgeon valuable updates on the latest thinking and practice in thefield.

This book provides readers with a succinct but comprehensive overview of current concepts relating to intestinal failure, including its treatment, with a particular focus on recent advancements. The opening chapters address basic aspects of intestinal failure, including etiology, clinical pathophysiology, physiology of intestinal adaptation, and intestinal microbiota. The complications of intestinal failure, such as bacterial overgrowth and intestinal failure-associated liver disease, are then discussed. A series of chapters specifically address important strategies in the nutritional, pharmacological, and surgical treatment of intestinal failure as well as the concept of intestinal rehabilitation. Finally, two significant emerging developments are considered: regenerative medicine and distraction enterogenesis. The authors are internationally recognized experts from Europe and North America who are ideally placed to describe current knowledge and progress in the field.

Consists of critical reviews and original research papers from the 2014 International Symposium on the'Biochemical Role of Eukaryotic Cell Surface Macromolecules'. Topics covered include: · neurochemical and biochemical analysis of cell surface glycoconjugates · membrane skeletal organization · GPCRs and other receptors · biophysical approaches to study membrane interactions · glycoconjugate metabolism · dysregulation · molecular mechanisms involved in cell-cell and cell-matrix interaction · glycans in infectious and neurological diseases · cancer and glycosyltransferases as drug targets.

Akute NierenschädigungDieses Springer-Buch bietet alles Erforderliche für das optimale Management der akuten Nierenschädigung. Frühzeitige Diagnose, rasche Therapie, kompetente Nachbetreuung sind bei der plötzlichen Verschlechterung der Nierenfunktion entscheidend für Überleben, Krankheitsverlauf und Prognose.Für Nephrologen, Intensivmediziner, Internisten und Chirurgen: Personelle und logistische Voraussetzungen, Kooperation inter-/intradisziplinär und stationär/ambulant, kompetente Entscheidungshilfen für den klinischen Alltag, Tipps &Tricks, technische Fallstricke, Fallbeispiele.Medizinisch und ökonomisch optimiert. Inhalt- Frühzeitige Diagnose: Frühwarnsystem, Algorithmen, Konsil-Checkliste, Risikopatienten identifizieren, bei welchen Patienten müssen welche Werte wann kontrolliert werden.- Rasche Therapie: optimale supportive bzw. kausale Therapie, Behandlungspfade, interdisziplinäre Behandlung.- Kompetente Nachbetreuung: Organisation der ambulanten Nachsorge: für wen und wie, präventive Maßnahmen, Patientenausweis. AutorenDr. Anja Haase-FielitzProfessor Dr. Michael HaaseKlinik für Nieren- und Hochdruckkrankheiten, Diabetologie und EndokrinologieOtto-von-Guericke-Universität Magdeburg

Das Praxisbuch der pulmonalen RehabilitationTherapieanleitung zur physiotherapeutischen Untersuchung und „nicht-medikamentösen'Behandlung von: chronischen Atemwegs- und Lungenerkrankungen (COPD) und respiratorischen Problemen als Begleiterscheinung bei neurologischen Erkrankungen (z.B. Querschnittlähmung, MS), progressiven Muskelerkrankungen, Thoraxtraumata oder nach Thorax- oder Bauchraum-Op.Neben den notwendigen Grundlagen der pulmonlen Rehabilitation vermittelt der Praxis-Teil Physiotherapeuten mit knappen, präzisen Textanleitungen und informativen Fotos alle evaluierten Untersuchungstechniken (Assessments) und Behandlungsverfahren (Interventionen) der pulmonalen Rehabilitation. Einen wichtigen Teil nimmt die Patientenschulung zum Aufbau von Leistungsfähigkeit und körperlicher Belastbarkeit durch Trainingstherapie ein.Neu in der 2. Auflage- Untersuchungsmethoden des Abdomen- Untersuchungsmethoden des Urogenitaltraktes- Ergänzung des Kapitels Verstärkung der peripheren Muskelkraft- Video-Material zum Downloaden

With the high prevalence of chronic pulmonary diseases, including asthma, COPD, and interstitial lung disease, physicians need to recognize the cause of dyspnea and know how to treat it so that patients can cope effectively with this distressing symptom. Detailing recent developments and treatment methods, this revised and updated third edition of

Sphingolipids are lipid components of the plasma membrane in eukaryotic cells. They have an important function in signaling mechanisms in the cell. This book on sphingolipids provides insights into the basics of sphingolipid biology and drug development, with a particular emphasis on the sphingolipid derivative ceramide. In the first part basic functions of sphingolipids are described, as well as the genetics of important enzymes, sphingolipid metabolism and synthesis. The second part of this first volume focuses on drug development and pharmacology. The book is intended for scientists in pharmacology, biochemistry and cell biology with a focus on biomedical research as well as for clinicians working in pharmacology, oncology, cardiology, neurology and infectious disease. Together with Volume 216 by the same editors, the collection represents a unique, comprehensive work on sphingolipids, providing information on both sphingolipids'basic biology (including synthesis, metabolism and cell biology) and their important function in a (patho-)physiological context.

Responsibility for the diagnosis and management of disorders of the pulmonary circulation has become the shared domain of the pulmonologist, cardiologist, surgeon, radiologist, pathologist, and, perhaps most important of all, the internist. It is the general internist who is most likely to care for the majority of patients with lung diseases that secondarily give rise to pulmonary heart disease, and it is the internist who will first evaluate the patient with primary pulmonary hyperten­ sion or recurrent pulmonary thromboembolism who presents with nonspecific complaints and may manifest subtle and nondiagnostic findings on preliminary evaluation. The burgeoning medical literature concerning aspects of the pulmonary circula­ tion, both clinical and investigative, is a reflection of the reawakening of great interest in this field and has led to many new developments, both in our understand­ ing of cardiopulmonary pathophysiology and in the diagnosis and treatment of pulmonary vascular diseases. This book is an attempt to provide the clinician with a comprehensive overview of pulmonary heart disease from the perspective of experts representing a variety of disciplines. It is intended to be thorough yet clinically relevant. Individuals familiar with some facets of pulmonary heart disease may gain insight into other aspects of this condition, whereas those unfamiliar with this disorder may find this work useful as a general reference or as a resource to address a specific question.

Cellular domains play vital roles in a wide range of cellular functions. Defining cellular domains and understanding the molecular basis of their formation is essential to the study of cell functionality. This authoritative reference provides the most comprehensive analysis available on cellular domains, with emphasis on the definition and molecular composition of the domain as well as the functional implications of domain organization.

This new book reviews research in the field of detergent types, their components and uses. Discussed herein are biosurfactants and their uses in the petroleum industry and in hydrocarbon pollution remediation; detergent-based DNA extraction techniques in molecular biology; enzyme usage as an active ingredient in detergents and the influence of different detergents on the preservation of the cytoskeleton and detergent-resistant membranes on whole-mounted cells. In this compilation, also explored, is the study on the synthesis, separation, analysis and performance of sulfo fatty methyl ester sulfonates as new anionic surfactants.

The Second Edition of Asthma and COPD: Basic Mechanisms and Clinical Management continues to provide a unique and authoritative comparison of asthma and COPD. Written and edited by the world's leading experts, it continues to be a comprehensive review of the most recent understanding of the basic mechanisms of both conditions, specifically comparing their etiology, pathogenesis, and treatments.• Each chapter considers Asthma and COPD in side-by-side contrast and comparison – not in isolation - in the context of mechanism, triggers, assessments, therapies, and clinical management• Presents the latest and most comprehensive understandings of the mechanisms of inflammation in both Asthma and COPD • Most extensive reference to primary literature on both Asthma and COPD in one source.• Easy-to-read summaries of the latest advances alongside clear illustrations

Foreword Barry Jacobs once memorably commented that the problem in understanding the role of serotonin in the brain was that it was implicated in virtually eve- thing but responsible for nothing [1]. Serotonin (5-HT) is defnitely implicated in the regulation of sleep but what does it do? Once seen as a sleep-promoting molecule, Jacob's own work, lucidly described in this volume, radically changed our view. In fact, serotonin neurons are most active during waking; their - tivity diminishes with sleep onset and disappears during rapid eye movement (REM) sleep. Serotonin, therefore, is intimately linked to the sleep-wake cycle, but what is its role, what mechanisms are involved and what are the impli- tions for sleep medicine and psychiatry? Making progress with these diffcult questions requires a “translational” approach, which is a research paradigm where both laboratory and clinical neuroscience inform and guide each other with the ultimate aim of improving understanding and treatment of medical conditions. This volume is a superb example of translational research, where leading basic and clinical scientists - tegrate molecular, neuropharmacological and systems approaches to illuminate the reciprocal interactions of serotonin neurons and the mechanisms involved in sleep and circadian regulation. Serotonin is an ancient chemical mediator preserved through at least 500 m- lion years of evolution. In invertebrate animals such as mollusks and leeches, 5-HT cells are distributed throughout the nervous system among the various ganglia.

Questo libro riporta lo stato dell'arte delle più comuni malattie dell'apparato respiratorio. La prima parte è dedicata all'anatomia del polmone, alla regolazione della respirazione e alla meccanica respiratoria, seguita dall'esame funzionale del paziente respiratorio e dalla diagnostica invasiva e non invasiva, inclusa la diagnostica per immagini in pneumologia. Nella descrizione delle malattie particolare importanza è stata data nel chiarire il'perché'dei diversi sintomi e segni clinici mentre l'approccio terapeutico, confrontato con le linee guida internazionali, fa comunque riferimento alla vasta esperienza clinica degli autori. L'obiettivo principale di questo libro è quindi quello di riportare le più recenti acquisizioni nella fisiologia, fisiopatologia e clinica delle malattie dell'apparato respiratorio, inclusa la ventilazione meccanica non invasiva, l'ossigenoterapia e la riabilitazione respiratoria, e di combinare una chiara descrizione della fisiopatologia respiratoria con enfasi alla sua applicazione clinica. Il volume è rivolto sia agli studenti del corso di laurea specialistica in medicina e chirurgia, sia agli specializzandi in malattie dell'apparato respiratorio. Rappresenta inoltre un valido riferimento per il medico di medicina generale, soprattutto quando quest'ultimo intenda aumentare le proprie conoscenze cliniche, diagnostiche e terapeutiche nel settore delle patologie respiratorie, branca che sempre più frequentemente coinvolge il medico e lo specialista nella risoluzione di casi anche molto complessi.

Pulmonary rehabilitation programmes are now a fundamental part of the clinical management of patients with chronic respiratory diseases. This comprehensive reference book places pulmonary rehabilitation within the wider framework of respiratory disease, and the health burden that this now poses worldwide. Part one of the book examines the evidence

Divided into three sections spanning the mechanisms of dyspnea, measurement and assessment strategies, and management techniques-this reference illustrates the impact of dyspnea on patients with chronic respiratory disease. With contributions by recognized experts on the topic, this handbook provides an abundance of practical information and recomm

This reference compiles the most current technical and biological data available to survey the state-of-science in the care and management of patients with bronchopulmonary dysplasia, COPD, and other forms of lung disease-tracking the initiation and progression of processes that cause airway obstruction, the biologic and physiological abnormalities

Surveying developments in coating polymers and plastics, this book examines proper materials selection, basic processing mechanics, process selection based on cost and coating mechanics, molding, and performance and durability assessments. This text is a reference tailored for busy professionals or students in coatings courses. It highlights techniques for salvaging plastics from used vehicles, including the recycling of automotive plastics, and compares North American and European techniques for coating plastics in the automotive industry.

This book brings a new approach to the subject of chronic obstructive pulmonary disease, highlighting the current areas of controversy and debate. It addresses many of the key issues surrounding the diseases, its causes, clinical assessment and management. Internationally renowned experts critically appraise the literature and combine this with their own clinical and research experience to present an informed view of a wide range of issues. Arguments are therefore supported by the most recently available evidence. Chronic Obstructive Pulmonary Disease – Critical Debates provides the reader with an up-to-date interpretation of the clinical trial data in this field and their relevance to daily practice.

Chronic obstructive pulmonary disease (COPD), which encompasses both chronic bronchitis and emphysema, is one of the most common respiratory conditions of adults in the developed world. Asthma and COPD: Basic Mechanisms and Clinical Management provides a unique, authoritative comparison of asthma and COPD. Written and edited by the world's leading experts, it is a comprehensive review of the most recent understanding of the basic mechanisms of both conditions, specifically comparing their etiology, pathogenesis, and treatments.• Highlights distinguishing features between asthma and COPD• Reviews benefits and limitations of current therapies• Summarises key information in two-colour artwork • Extensively referenced to primary literature

This useful reference provides comprehensive reviews of the physiological foundations of the control of breathing and offers new insights into the pathophysiology, diagnosis, and management of breathing disorders in respiratory, cardiac, neuromuscular, and metabolic-endocrine diseases.Control of Breathing in Health and Diseasesheds new light on the central neural mechanisms controlling breathing and the important chemical, neuromechanical, and behavioral systems that are responsible for setting the level and pattern of breathing investigates the neural basis of respiratory sensation and the mechanisms of breathlessness addresses the systems that are responsible for assuring the adequacy of ventilation during exercise considers the structural, mechanical, and neural mechanisms influencing upper airway patency reviews the physiological mechanisms of Cheyne-Stokes breathing charts the influence of gender, menstrual cycle, and pregnancy on ventilatory control presents current approaches to the clinical assessment of the control of breathing discusses breathing abnormalities in the newborn and infants and changes in breathing patterns in the elderly evaluates the mechanisms and management of sleep-disordered breathing analyzes abnormalities in breathing control in chronic obstructive and interstitial lung diseases, heart failure, neurological diseases, muscular dystrophy, and thyroid disorders, diabetes, and acromegaly outlines modern approaches to the management of respiratory failure and more!Including more than 2200 references, tables, equations, and drawings, Control of Breathing in Health and Disease benefits pulmonologists; physiologists; chest, pulmonary, thoracic, and cardiovascular physicians and surgeons; asthmologists; cardiologists; respiratory therapists; and upper-level undergraduate, graduate, and medical school students in these disciplines.