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Image-based biomarkers that report on specific cell phenotypes in the body are highly valued for disease detection and monitoring cytotherapies. Towards this need, there is sustained scientific interest in fluorine-19 (19F) magnetic resonance imaging (MRI) for in vivo molecular–cellular imaging applications. The attraction of 19F tracer MRI is its ability to produce pure ‘hot-spot'images, an absence of false-positive signals, robust quantification, and tracer safety. For molecular–cellular applications, fluorine MRI does not require a pre-scan prior to tracer administration, thus offering several advantages over metal–ion-based proton (1H) contrast-agent approaches. Key applications of 19F MRI include cell tracking, inflammation detection, and biosensing. Fluorinated imaging tracers can also serve as therapeutic agents or drug-delivery vehicles. Over the past decade, the field of 19F MRI has seen remarkable innovation in tracer designs and detection methods as well as the realization of its clinical potential.This book is an interdisciplinary compendium detailing cutting-edge science and biomedical research in the emerging field of 19F MRI and includes technical issues, such as pulse sequence considerations and limits of detection of the techniques; synthesis of novel 19F MRI tracer agents; inflammation, cancer, and stroke imaging; regenerative brain repair; theranostic nanomedicine; and clinical perspectives. The book will appeal to investigators involved in MRI physics, biomedicine, immunology, pharmacology, and probe chemistry as well as general readers.

Yeast Sugar Metabolism looks at the biomechanics, genetics, biotechnology and applications of yeast sugar. The yeast Saccharomyces cereisiae has played a central role in the evolution of microbiology biochemistry and genetics, in addition to its use of a technical microbe for the production of alcoholic beverages and leavening of dough.

Offering a novel and interdisciplinary approach, this thought-provoking book critically analyses the notions of fragility and antifragility and addresses their connections and applications in planning theory, urban studies and architecture. It goes beyond the risk and resilience paradigm and proposes methodological and pragmatic strategies to cope with severe forms of uncertainty and socio-spatial inequalities.Showcasing expert contributions from leading scholars, this book illustrates how a specific research focus on fragility and antifragility may elucidate some key value-based facets of contemporary cities and regions in order to foster sustainability, innovation and justice. Chapters examine the theoretical and political dimensions of fragility and antifragility, exploring how these two opposing concepts can reimagine traditional rationality in public action and potentially reframe the methods used by architects, urban planners, and policy makers. Exploring conceptual, methodological and case-based aspects, this incisive book will be of great interest to academics and students within the fields of urban studies, cities and urban geography, architecture, social sciences, philosophy, technology and innovation studies. Its presentation of original accounts of antifragile plans, policies and projects will further benefit policy makers practising within these areas.

The field of medicinal/aromatic plant breeding is growing and changing?this resource will help you stay up to date! In this essential book, researchers from large and small laboratories and institutions throughout Europe and the Mediterranean region explore recent developments in the selection and breeding of aromatic and medicinal plants. They take varied approaches?from traditional breeding to the use of molecular markers?and complement them with up-to-date information on biodiversity and resource conservation. From the editors:?It is widely recognized that a strategy of `conservation through use,? by which plant collection via wild harvesting is replaced by controlled cultivation, is the best way forward if we are to balance human demands with the necessary conservation of the biodiversity represented by these species. That provides one major driving force for research in this field. Another concerns the very real need for improving the quality control of products on the market, both to satisfy consumer demand and to conform with the (justifiably) increasing requirements for standardization and precise identification of the composition of the plant materials being sold for human use. We hope that this volume will give readers a taste of the exciting developments in the field.? Breeding Research on Aromatic and Medicinal Plants examines: breeding for resistance and abiotic factors manipulating natural product accumulation through genetic engineering biochemical and molecular regulation of essential oil accumulation economic and legal considerations that breeders will encounter the ethical aspects of breeding these plants

Service organizations are grappling with unprecedented challenges in maintaining and enhancing productivity. As the landscape evolves, traditional approaches to service operations become obsolete, necessitating a deep understanding of the intricate dynamics at play. Innovative Technologies for Increasing Service Productivity delves into this urgent issue, offering a comprehensive exploration of the trends and challenges confronting service industries. The book sheds light on the impact of digital transformation, emerging technologies, and disruptive business models, serving as a guide for navigating the complexities of service productivity in an ever-changing environment. As a groundbreaking solution, this book not only identifies challenges but provides various solutions for service organizations to thrive amidst technological disruption. Its unique selling points lie in the breadth of its coverage, spanning diverse service industries and dissecting the symbiotic relationship between technology and productivity. Offering practical strategies and tools, the book equips service professionals with the means to enhance productivity, quality, and customer experience. By connecting the gap between theoretical insights and practical implementation, it stands as a valuable resource for academics, researchers, and service managers seeking innovative solutions to the evolving landscape of service productivity. The objective of this work extends beyond merely highlighting problems—it contributes substantively to the literature on service productivity. By seamlessly weaving together research findings, case studies, and the best practices from global service industries, the book enriches the collective knowledge base. Moreover, its relevance is underscored by its examination of social, economic, and environmental factors influencing service operations, providing a comprehensive view that is indispensable for policymakers. In essence, Innovative Technologies for Increasing Service Productivity offers a transformative blueprint, empowering stakeholders to navigate and thrive in the era of digital service evolution.

This reference book compiles the recent advances in computational and experimental modelling to screen and manage Alzheimer's disease. It covers basic etiopathology and various in vitro and in vivo strategies of disease intervention. The book discusses how computer-aided drug design approaches reduce costs and increase biological test efficiency. It reviews the screening for anti-Alzheimer drugs and biomarker analysis of disease inhibitors. The book also explores mechanistic aspects of neurodegeneration and the use of natural products as therapeutics for Alzheimer's disease.Key features: Elaborates on the computational modelling of protein target inhibitors as anti-Alzheimer's agents Explains the role of phytomolecules and natural products in Alzheimer's therapy Reviews preclinical ways to assess drugs focusing on Alzheimer's disease Covers biomarker analysis for Alzheimer's disease Discusses the onset and progression of Alzheimer's disease The book is meant for professionals, researchers, and students of neuroscience, psychology, and computational neurosciences.

This book contains the proceedings of the Cambridge Unsteady Flow Symposium, held on 4–5 March 2024 at the University of Cambridge. The book brings together internationally leading experts in computational fluid dynamics (CFD) and promotes discussions on numerical methods for unsteady flows. The book covers a wide range of topics related to CFD, including but not limited to, large-eddy simulations, unsteady flows in aerospace, high order methods, and mesh generation.

The book presents selected materials received as part of the International Scientific Conference “Digital Transformation on Manufacturing, Infrastructure and Service” (DTMIS 2022) and may be of interest to: Undergraduate, graduate students and postgraduate students in the areas of economics, business engineering, enterprise management, sustainable development; University professors teaching courses such as Digital Economy, Energy Economics, Knowledge Economics, Integrated Course Project, Public Administration, Management, and so on; Scientists conducting research in the field of digital transformation of industries, services, and construction, as well as managing complex processes in enterprises within the framework of a dynamic development of the external environment. This book contains a wide range of directions in the economy that are brought together under one trend - digital transformation.

La vicenda di Anfitrione è tra i miti antichi più ripresi in età moderna: valoroso condottiero e sposo felice di Alcmena, l'eroe è vittima di un inganno perpetrato da Giove, che ne assume le sembianze per sedurne la sposa e generare con lei il semidio Ercole. Connesso da un lato all'archetipo del fanciullo divino, figlio di un dio e di una donna mortale, dall'altro al tema del doppio, il mito si è prestato a molteplici riletture. Tra i testi qui proposti – coincidenti con i momenti chiave della lunga storia di Anfitrione – la «tragicommedia» di Plauto si impone come ineludibile punto di partenza: commedia degli equivoci e degli inganni, incentrata sul «furto di identità» (nasce da qui il significato moderno di «sosia»), l'Anfitrione plautino è un esempio di come la cultura antica intendeva il tema del doppio. L'adulterio è invece al centro dell'Amphitryon di Molière, che rilegge il modello antico adattandolo alla realtà e ai gusti del suo tempo: sulle inquietudini del doppio prevale la beffa ai danni del marito tradito. Ancora diverso il testo di Kleist: apparentemente ispirato al fortunatissimo modello molieriano, in realtà se ne distacca radicalmente, sviluppando in modo originale il potenziale tragico della vicenda. Segnata dal conflitto tra apparenza e realtà, la commedia di Kleist appare perciò venata da una sottile amarezza. Infine, l'Amphitryon 38 di Giraudoux, meno noto al pubblico italiano, è forse la più brillante tra le varie riprese del mito nel Novecento: commedia degli equivoci lieve e ricca di humour, pone in primo piano il tema della coppia che miracolosamente resiste alle insidie del destino ed esalta il personaggio di Alcmena come donna padrona di se stessa e capace di gestire la propria vita.

The field of muscular dystrophies has expanded significantly with the discovery of the genetic defects and protein products underlying these disorders. New treatments such as antisense oligonucleotides and siRNAs and gene therapies are now in clinical application and in trials. As clinical trials increase, outcome measurement becomes very important, and more validated tools are being developed. This book provides a comprehensive review of these disorders. Clinical features, diagnostic testing including genetic testing of these disorders, the basis and utility of genetic testing, and the basis of genetic therapies are all covered in detail. This book will provide neuromuscular neurologists, general neurologists, and neuromuscular fellows with a much needed update in the field.

Molecular Biomarkers in Cancer Detection and Monitoring of Therapeutics: Volume Two: Diagnostic and Therapeutic Applications discusses how molecular biomarkers are used to determine predisposition, facilitate detection, improve treatment and offer prevention guidelines for different cancers. It focuses on novel diagnostic techniques based on molecular biomarkers and their impact on treatment, covering different cancer types such as tumors in the nervous system, head and neck, oral and GI tractor, lung, breast, gastric system, leukemia and urogenital tract cancers. For each type, the book discusses the best diagnostic techniques and therapeutic approaches, thus helping readers easily identify the best solution for each case. This is a valuable resource for cancer researchers, oncologists, graduate students and other members of the biomedical field who are interested in the potential of biomarkers in cancer research. - Provides up-to-date information on current molecular biomarkers research for cancer - Presents new diagnostic techniques using biomarkers that can leverage quicker results that can be essential for patient's survivorship - Discusses several novel therapeutics applied to specific cancer types, such as head and neck, oral, GI tract, breast, lung and hepatocellular carcinomas

Come possono i personaggi imporsi di vivere dentro una scelta di una mortificazione perenne? Come può un uomo costringersi in un distacco dal mondo delle passioni e dei desideri, rifiutati in blocco come realtà assolutamente negative? Nel panorama di un mondo inteso come il campo da gioco di un destino ineluttabile e amaramente tragico, i romanzi di Deledda pongono subito un problema profondamente morale. Il peso della colpa infrange nell'io qualsiasi tentativo di vita esteriore e sociale, portandolo a una vertiginosa parabola finale aperta tra due possibilità: la tragica e presentita esperienza del nulla e la flebile luce drammatica del perdono. Assistiamo a una dimensione eminentemente deleddiana di sentire la vita e le sue urgenze, derivata di filato da un certo sentimento religioso, inteso lato sensu come rapporto col mistero e col destino. La scrittrice ci ricorda che il male esiste, così come esiste il peccato. La sua forza anti-ideologica novecentesca ci ribolle tra le mani, nella libertà tragica che lei dipinge. Una Deledda estrema che ci trascina in un misto di fascino e repulsione sino alle domande ultime dell'uomo.

Advances in Biomolecular EPR, Volume 666 in the Methods of Enzymology series, highlights new advances in the field, with this new volume presenting interesting chapters on topics including Magnetic Resonance Characterization of Physiologically Important Metal Ion Binding Sites in the Prion and Related Proteins, The catalytic role of metal-radical/protein-based radicals in heme enzymes, Rigid Cu2+-based spin labels for the study of higher-order DNA G-quadruplex structures, Orthogonal spin labeling and membrane proteins: increasing the information content and going towards in cell applications, Spectroscopic investigation of mono- and di-Mn-containing centers in biochemistry with an emphasis on application of paramagnetic resonance techniques, and more. Additional chapters cover In Vivo pO2 Imaging of Tumors: Oxymetry with Very Low-Frequency Electron Paramagnetic Resonance, an Update, EPR contributions to understanding molybdenum-containing enzymes, EPR spectroscopy of Type I reaction centers, Characterization of a substrate-derived radical in the NosN reaction during the biosynthesis of nosiheptide, and much more. - Provides the authority and expertise of leading contributors from an international board of authors - Presents the latest release in Methods in Enzymology series - Includes the latest information on Advances in Biomolecular EPR

Improving Sustainable Practices in Viticulture and Enology provides an up-to-date view on the major issues concerning the sustainability of the wine supply chain. The book describes problems and solutions on the use of inputs (e.g., water, energy) and emphasizes the roles and limitations of implementing circularity in the sector. It identifies some of the most relevant metrics while pinpointing the most critical issues concerning the environmental impacts of wine's supply chain (vineyards, wineries, trading). This is a novel reference to help the industry excel in production while improving current environmental practices. Professionals in industry, academics, environmentalists and anyone interested in gaining knowledge in sustainable solutions and practices in viticulture and wine production will find this resource indispensable. - Suggests and discusses solutions to overcome challenges imposed by adverse climate conditions - Presents innovative technologies that have an impact on the efficiency of resources and recycling - Includes technological tools for more precise monitoring and management in the wine supply chain

This second edition offers a fully revised and updated work on a rapidly growing field of knowledge, and was prepared by two experts whose goal was to explain the molecular basis of mosaic skin disorders in a language that is accessible for practicing physicians and medical students alike. It presents a timely and comprehensive overview of the strikingly manifold patterns and peculiarities of mosaic skin disorders in a straightforward, reader-friendly way that will help physicians to further improve genetic counseling and treatment outcomes.The first two parts of the book are devoted to the mechanisms and patterns of cutaneous mosaicism, and include an explanation of genomic and epigenetic mosaicism and a description of the archetypical segmental patterns including the lines of Blaschko and the flag-like, phylloid and lateralization pattern, the non-segmental pattern of large congenital melanocytic nevi, and the sash-like arrangement as noted in a particular type of cutis tricolor. The concept of lethal mutations surviving as mosaics has now been confirmed by molecular analysis in many sporadically occurring phenotypes. The difference between monoallelic and biallelic traits has deepened our understanding of hereditary mosaics, especially of multiple benign skin tumors. Moreover, recognition of the fundamental difference between the simple segmental and the superimposed types of mosaicism is important for the purpose of genetic counseling. In the third part, the various mosaic skin disorders are examined in depth, including nevi, didymotic disorders, other binary genodermatoses, mosaic manifestations of autosomal skin disorders, and nevoid skin disorders such as phenotypes reflecting functional X-chromosome mosaicism or a superimposed mosaic manifestation of common skin diseases with a polygenic background. Reader-friendly and clearly structured, Mosaicism in Human Skin will appeal to both experienced dermatologists and residents in training, as well as to medical geneticists and pediatricians.

Dairy science includes the study of milk and milk-derived food products, examining the biological, chemical, physical, and microbiological aspects of milk itself, as well as the technological (processing) aspects of the transformation of milk into its various consumer products, including beverages, fermented products, concentrated and dried products, butter and ice cream. This encyclopedia includes information on the possible impact of genetic modification of dairy animals, safety concerns of raw milk and raw milk products, peptides in milk, dairy-based allergies, packaging and shelf-life and other topics of importance and interest to those in dairy research and industry. The Encyclopedia of Dairy Sciences, Five Volume Set is the only work available that covers in detail the entirety of dairy science, from husbandry of dairy animals, milk production, through the processing of milk into a myriad of dairy products and ingredients, to the effect of dairy foods on human health. The third edition of Encyclopedia of Dairy Sciences will retain the split that characterized the earlier editions - one-third primary production, two-thirds dairy food. Unlike earlier editions, in which articles were arranged in alphabetical order by topic, this edition will be optimally organized into 9 coherent sections. This new edition contains 500 articles, the vast majority of which has been significantly revised or is completely new. Only 40 chapters have been retained from the earlier edition as they cover basic science areas still relevant and important today. All articles have been reviewed by specialists in their area. - Comprehensive and authoritative introductory articles on all aspects of dairy science from on-farm aspects, to processing, to consumers - Content is written and edited by leading authorities from across the globe making this the go-to foundational reference in the dairy science community - Articles are intuitively and meticulously organized into 9 coherent sections on key topics, making it easier for the reader to access relevant information quickly

This book is ideal for the practicing clinician looking to better understand how our environment impacts the lung. A compilation of reviews explores how clinicians can be aware and better determine environmental effects on lung health, and provides guidelines for medical providers to diagnose, counsel and mitigate risk. Various lung diseases are affected by the external environment. Asthma is common, however other airways diseases, such as interstitial lung disease, malignancies, and even adverse effects from reactions treatments for other medical conditions can affect the health of the lungs. While there are books and chapters written on occupational lung disease and environmental causes of asthma, the intent of this body of work is to address the exposome and the effects on a broader group of lung disease. In addition to information on traditional exposure sources, such as air pollution and occupational exposures, this resource explores newer areas of interest, including lung disease from recreational inhalants and the role of climate change on lung health. Written by expert respiratory specialists, the articles cover a wide range of topics, including: How air pollution effects airways disease, including asthma, COPD, and cystic fibrosis Risk factors and effects of indoor mold exposure Both medical and non-medical exposures that increase the risk of or cause interstitial lung disease (ILD) also known as diffuse parenchymal lung disease (DPLD) Acute and chronic lung disease associated with recreational inhalants The epidemiologic and molecular mechanisms of air pollution effects on pulmonary hypertension Climate change and weather-related lung health issues Areas in this field that need further evaluation

Tuberculosis is an important concern in numerous countries across the globe. Training is usually focused on pulmonary tuberculosis, and the nuances of diagnosis and management of extrapulmonary tuberculosis, including abdominal tuberculosis, are not usually emphasized. This book details the varied presentations and mimics of tubercular involvement of the abdomen and the gastrointestinal system..The book provides clear guidance to the clinicians to diagnosis and manage the varied forms of abdominal tuberculosis. The chapters also touch on areas of controversy and confusion. Chapters are focused on each of the sites (intestinal, peritoneal, gastroduodenal, hepatobiliary, and pancreatic), modalities for evaluation (histology, microbiology, radiology, endoscopic ultrasound, nuclear medicine), differential diagnosis, and follow-up including response to treatment. Separate chapters have also been devoted to pediatric abdominal TB, therapy-related hepatitis, and considerations in immunocompromised states such as HIV. Therefore, this book will help practice clinicians and serve as a one-stop resource for graduate students in internal medicine and fellows training in gastroenterology.

Clinical Perspectives and Targeted Therapies in Apoptosis: Drug Discovery, Drug Delivery, and Disease Prevention provides comprehensive coverage, from basic cell biology, to modern assessment techniques for apoptosis in all major disease areas. Chapters provide an introduction to the fundamentals of cell biology, biochemical mechanisms, and the pathophysiological consequences of apoptosis. In addition, the book covers the tools and techniques used to quantify apoptosis and the significance of apoptosis in drug discovery, drug delivery, and its applications in disease prevention. Finally, the book provides a comprehensive compilation of the apoptosis targeting drugs that recently underwent clinical trials. This combination of fundamentals, along with applications in drug discovery, drug delivery, and clinical research make this book a useful resource for those in both academia and industry who are engaged in pharmaceutical, biomedical and biotechnology research. - Offers standard and innovative therapeutic approaches to modulate apoptosis in clinical interventions, such as cardiovascular diseases, immune disorders, cancer chemotherapy and neurological ailments - Covers cutting-edge laboratory techniques and traditional protocols to determine apoptosis, both in vitro and in vivo - Examines clinical study reports of new drug moieties that are explored for various pathological conditions associated with apoptosis

The Hypothalamus is an important area of the brain for understanding a variety of neurological disorders. This volume summarizes for readers the anatomy and physiology of the anterior hypothalamus, to better understand pathology and treatment of hypothalamus related disorders. In addition to anatomy and physiology in humans, cytoarchitecture and chemoarchitecture in rodents is provided. The volume explores the role of the hypothalamus in disorders of eating, sleeping, anxiety, and mood, as well as its role in sexual behavior and gender identity. Coverage includes how Parkinson's, Alzheimer's and other neurological disorders relate to the hypothalamus. - Reviews the anatomy and physiology of the anterior hypothalamus - Provides cytoarchitecture and chemoarchitecture from rodents - Discusses hypothalamic related disorders of eating, sleeping, anxiety, and mood - Covers how Parkinson's, Alzheimer's and other neurological disorders relate to the hypothalamus - Explores the role of the hypothalamus in sexual behavior and gender identity

This book provides an original review of Ocean Literacy as a component of public policy in Europe and beyond. The impact of the ocean on human activities is one of the most significant environmental issues facing humanity. By offering valuable insights into the interrelationships between geography, environment, marine science and education, the book explores key issues relating to the future of our planet and the way people respond to them. This volume discusses concepts concerning citizenship education and co-creation and the role of public policy and different international initiatives in raising awareness and mitigating the effects of over-use and misuse of valuable resources. A range of innovative projects are presented and evaluated from the local to national and global levels.This book advances knowledge and provides a picture of these advances, presents the issues and challenges, including the important role that geography education and geographical awareness could play inadvancing the case for Ocean Literacy.This crossdisciplinary book appeals to students and scientists as well as professionals and practitioners in geography, environmental and marine sciences, international policy and many related fields.

Managing Wine Quality, Volume 2: Oenology and Wine Quality, Second Edition, brings together authoritative contributions from experts across the world's winemaking regions who cover yeasts, fermentation, enzymes, and stabilization, amongst other topics. A new chapter covers, in detail, extraction technologies and wine quality. Other sections cover the management of wine sensory quality, with new chapters covering the management of fortified wines, of Botrytized wines, and of wines produced from dried grapes. In addition, an updated section on insect taints in wine has been widened to cover all insects. With a focus on recent studies, advanced methods, and a look to future technologies, this fully updated edition is an essential reference for anyone involved in viticulture and oenology who wants to explore new methods, understand different approaches, and refine existing practices. - Reviews our current understanding of yeast and fermentation management, as well as the effects of aging on wine quality - Details alternatives to cork in bottle closing and the latest developments in the stabilization and clarification of wines - Includes new chapters covering extraction technologies for wine quality and on managing the quality of a wide range of wine types, including fortified and Botryized wines - Provides extensively expanded coverage of insect taints and their effects on wine quality

Based on the most current evidence and best practices, Perioperative Medicine: Managing for Outcome, 2nd Edition, is an easy-to-follow, authoritative guide to achieving optimal outcomes in perioperative care. Written and edited by recognized authorities in anesthesiology and surgical critical care, this fully updated edition helps you think critically about complex, long-term issues surrounding the care of the surgical patient, providing decision trees that define strategies to enhance the medical outcome of care. - Focuses on what anesthesiologists, surgeons, and intensivists need to know in order to improve outcomes through evidence- and outcome-based approaches. - Provides practical guidance on potential risks to all major organ systems, the etiology of particular organ dysfunctions, preoperative and intraoperative risk factors, and perioperative protection strategies to minimize potential complications. - Features a consistent chapter format - with even more color-coded algorithms, summary tables, and boxes – that enables you to quickly explore and determine the best management approaches. - Includes six all-new chapters: Perioperative Fluid Management; Delirium and POCD; Role of Palliative Care/ICU; Value-Based Care: The UK Model; CFO Perspective on Value; Hospital to Home (Perioperative Transitions of Care) - Discusses timely topics such as quality improvement, pay-for-performance, preexisting disease and comorbid conditions in anesthesiology, and the team-based model of care. - Features two new editors, surgeon Clifford Ko, MD, and Perioperative Summit leader, Michael (Monty) Mythen, MD.

This edited book focuses on the role and use of VR for healthcare professions in both health and rehabilitation settings. It is also offers future trends of other emerging technology within medicine and allied health professions. This text draws on expertise of leading medical practitioners and researchers who utilise such VR technologies in their practices to enhance patient/service user outcomes. Research and practical evidence is presented with a strong applied emphasis to further enhance the use VR technologies within the community, the hospital and in education environment(s). The book may also be used to influence policymakers on how healthcare delivery is offered.

Die Arbeit behandelt die Begnadigung in rechtsvergleichender Perspektive. Mit einer detaillierten und systematischen Darstellung der Regelungen und der Literatur in vier Rechtsordnungen (Deutschland, Italien, Frankreich, Griechenland) werden die vier Schwerpunkte der Gnadendiskussion rekonstruiert: Die Rechtsnatur der Gnadenentscheidungen; die rechtlichen Grenzen der Kompetenz; die Motivation der Gnadenentscheidungen; die Frage des Kompetenzträgers. Diese Probleme werden vor dem Hintergrund großer Themen des Rechts reflektiert; umfangreiche Analysen über die Gewaltenteilung, die Zwecke des Strafrechtssystems, die Gerechtigkeit, den politischen Charakter des Rechts, die Struktur des parlamentarischen Systems und die Funktion des Staatsoberhauptes erlauben es, über die Grenzen der Gnadenliteratur hinaus zu gehen und etablierte Meinungen in zentralen Gnadenfragen zu widerlegen. Abschließend wird die symbolische Funktion der Begnadigung auf rechtsphilosophischer Ebene diskutiert; die Arbeit zeigt, daß das Gnadeninstitut in seiner Darstellung durch das Schrifttum ein intrasystematisches Element der Legitimierung des Strafrechts bildet, indem es als zusätzliche'Richtigkeitsgarantie'der Bestrafung fungiert. Aus einer Systematisierung der Daten über die Gnadenpraxis ergibt sich jedoch, daß diese Garantie keine reale Entsprechung hat. Die Klärung juristischer Probleme der Gnadenkompetenz einerseits und die Analyse des symbolischen Stellenwerts der Begnadigung andererseits sind wesentliche Leistungen der Arbeit in einem vom neueren Schrifttum unverdienterweise vernachläßigten Bereich.

A consummate classic with a fresh approach to pediatric dermatology Children's skin is different. Maturation affects the epidermal barrier, the cutaneous microbiome, adnexal structures, vasculature, and transcutaneous absorption of drugs. The immature skin is more susceptible to pathogens and environmental disruption. Many genetic disorders are either present at birth or manifest early in childhood. Skin diseases thus present differently in children than in adults. Pediatric dermatology has seen significant advances over the last decade, particularly in the field of molecular genetics research, which has furthered our understanding of the pathogenesis of many skin diseases and the development of new approaches to treatment. This fourth edition of the Harper classic provides state-of-the-art information on all aspects of skin disease in children. It covers the diagnosis and treatment of all conditions - both common and rare - with a consistently evidence-based approach. Existing content has been refreshed and fully updated to reflect emerging thinking and to incorporate the latest in research and clinical data - especially at the genetic level. This new fourth edition includes: Greater focus on the genetics behind skin disease, including new genes/genodermatoses, progress in genetic analysis, and stem cell transplants Increased coverage of lasers and other technologies used to treat skin disease More summary tables, learning points, tables of differential diagnosis, and clinical algorithms for diagnosis and management Additional online features, including patient information links and multiple choice questions Harper's Textbook of Pediatric Dermatology delivers crucial clinical insights and up-to-date research information that spans the breadth of the field. As the most comprehensive reference book on this subject available, this revised fourth edition will support and guide the daily practice of both dermatologists and pediatricians across the world.

'Eta zer den ene beste esku hau, ezabatzen baitu idazten dudana oro; eta zer den eztarri hau ere, beste baten hitzak ahoskatzen baititu; eta zer diren ene oinak, eromenaren bidean galtzen baitira, eta egiten baitute tristuraren deserrian herri, esperantzaren aberrian atzerri'. Hala idazten du autoreak, akufenoak deitutako atalean, eta deserri horretan, atzerri horretako duda-mudetan ez atzera ez aurrera eraikitzen du bere literatur lan heldu bezain kezka sortzailea, umorearen hariz, absurduaren ehunean.

A primary concern of rare disease diagnosis is the lack of accurate information that may lead to delayed interventions, administering inaccurate treatments, and social consequences. Health communication continues to be one-way and rely on the expertise from the health practitioner. In such a broad spectrum of rare diseases, patients may find it difficult to obtain timely information, accurate diagnosis, and appropriate treatments, surgeries, medications, or psychological counseling in their own countries. The use of information and communication technologies can create new communication channels that address this lack of knowledge. Communicating Rare Diseases and Disorders in the Digital Age is an essential reference source that uses computer-mediated communication to improve patient knowledge when afflicted or dealing with rare health conditions. Featuring research on topics such as support networking, eHealth management, and social computing, this book is ideally designed for health practitioners, physicians, patients, medical administrators, nurses, surgeons, infectious disease educators, hospital directors, world health organizations, academicians, students, and researchers seeking coverage on current advances in health communication, computer science, and epidemiology.

This updated and revised second edition of “Alcohol and Tobacco” reflects the new ICD 11 and DSM V classifications and provides comprehensive descriptions of new therapeutic approaches, outlining the different interactions between personality, environment and the effects of the respective substance. In addition to new data on prevention-based therapies, especially for smoking addiction, the book also presents essential psychological and sociological strategies, and medication-based therapies. Particular attention is given to new medications and new compounds for e-cigarettes, while a broad overview of the American and European epidemiology of alcohol and nicotine addictions rounds out the coverage. Given the breadth and depth of its coverage, the book will appeal to a wide readership, from professionals to researchers and students.

Following many cases of suspected food poisoning in the Karamoja region of the Republic of Uganda, the meeting provided risk assessments for hyoscyamine and scopolamine, including toxicological and exposure assessment.

Alkohol- und Tabakabhängigkeit treten meist gepaart auf und stellen nach wie vor ein großes medizinisches und soziales Problem dar. Die therapeutischen Möglichkeiten und Motivationsstrategien wurden in den letzten zehn Jahren deutlich verbessert. Heute können Untergruppen von Abhängigkeitserkrankungen definiert werden, die mit einer spezifischen Medikation und mit maßgeschneiderter Psychotherapie wesentlich bessere Langzeitergebnisse haben, als die früher üblichen starren Abstinenzprogramme. Dieses Buch widmet sich diesem neuen therapeutischen Ansatz. Es wurde in zweiter Auflage vollständig überarbeitet und um aktuelle Erkenntnisse erweitert. Neben neuen Strategien zur Prävention und Diagnostik (ICD-11 und DSM-5) werden schwerpunktmäßig psycho- und soziotherapeutische sowie medikamentöse Ansätze mit realistischen Therapiezielen in Bezug auf Untergruppen vorgestellt. Darüber hinaus wurden zahlreiche neue relevante Aspekte aufgenommen, wie die Temperamentsdiagnostik nach Akiskal, die Bedeutung der individuellen Chronobiologie, Lebensqualität als Therapieziel, „Cut Down“ oder Abstinenzorientierung sowie Entzugsmedikation und die Bedeutung neuer Anticraving-Medikamente. Das Buch richtet sich an alle Berufsgruppen, die Alkohol- und Tabakkranke therapeutisch begleiten.

This open access book features a selection of high-quality papers from the presentations at the International Conference on Spectral and High-Order Methods 2018, offering an overview of the depth and breadth of the activities within this important research area. The carefully reviewed papers provide a snapshot of the state of the art, while the extensive bibliography helps initiate new research directions.

D'une perspective scientifique, cet ouvrage en langue anglaise contribue au débat sur l'enseignement des méthodes de la recherche en sciences sociales au niveau universitaire, sur la base des expérience pédagogiques des auteurs.

Wine is one of the oldest forms of alcoholic beverages known to man. Estimates date its origins back to 6000 B.C. Ever since, it has occupied a significant role in our lives, be it for consumption, social virtues, therapeutic value, its flavoring in foods, etc. A study of wine production and the technology of winemaking is thus imperative.The preparation of wine involves steps from harvesting the grapes, fermenting the must, maturing the wine, stabilizing it finally, to getting the bottled wine to consumers. The variety of cultivars, methods of production, and style of wine, along with presentation and consumption pattern add to the complexity of winemaking. In the past couple of decades, there have been major technological advances in wine production in the areas of cultivation of grapes, biochemistry and methods of production of different types of wines, usage of analytical techniques has enabled us to produce higher quality wine. The technological inputs of a table wine, dessert wine or sparkling wine, are different and has significance to the consumer. The role played by the killer yeast, recombinant DNA technology, application of enzyme technology and new analytical methods of wine evaluation, all call for a comprehensive review of the advances made.This comprehensive volume provides a holistic view of the basics and applied aspects of wine production and technology. The book comprises production steps, dotted with the latest trends or the innovations in the fields. It draws upon the expertise of leading researchers in the wine making worldwide.

Il Tribunale speciale per la difesa dello Stato, strumento di repressione politica, fu creato dal fascismo perché, si è sostenuto, non aveva fiducia nella magistratura ordinaria. Ma cosa è stato quest'organo e che ruolo ha avuto nell'assetto istituzionale del regime? In realtà l'obiettivo era una riforma in senso fascista dell'intero sistema della giustizia; il Tribunale speciale voleva essere una specie di prova generale. Alla sua attività contribuirono, insieme ai magistrati militari e ai membri della Milizia, proprio i magistrati ordinari, con le prassi tipiche della magistratura, la loro cultura, ma anche il loro zelo repressivo. Basato su documenti inediti, lo studio indaga il concreto funzionamento del Tribunale e gli esiti, spesso contraddittori, della sua azione, senza trascurare la personalità dei giudici dei quali traccia un penetrante ritratto di gruppo.

This book provides essential information on a wide range of important issues in health sciences relating to child development, nutrition and dietetics, nursing, midwifery, and general health services. It also examines some issues and concerns in health management, including organizational trust in health care; artificial intelligence in healthcare, community-based rehabilitation in cerebral palsy; and digital marketing in the health sector.Contributions in each chapter are prepared by experts in the respective fields, and mirror advances in the respective field. This book sets out a number of important future tasks within the field, and supplies extensive bibliographies at the end of each chapter, as well as tables and figures that illustrate the research findings. All these make this book highly useful and a ‘must-read'for students, researchers, and professionals in health sciences.

The book covers all relevant topics of uropathology (tumoral and non-tumoral), from the normal histology of the genitourinary tract to pathological findings of diseases in the male genital and urinary tract. To make the content more accessible, all content is arranged alphabetically and each entry is uniformly structured, presenting the epidemiology, the clinical signs, the gross and histological features, the immunohistochemical stainings, and the molecular data for each disease. Histological pictures clarify the microscopic findings and help readers understand the differential diagnosis for genitourinary tract diseases. In addition to internationally respected experts on pathologies of the prostate, bladder, kidney and testis, researchers coming from other disciplines such as molecular biologists, soft tissue pathologists, dermatopathologists, hematopathologists and gynaecopathologists have contributed to this book, thus making it interesting for uropathologists, but also for students, residents, clinicians (surgeons, radiotherapists, oncologists, urologists, dermatologists) and researchers who deal with disciplines that call for knowledge of the pathologies of the male genital and urinary tracts.

Late aging associated changes in alcohol sensitivity, neurobehavioral function, and neuroinflammation, Volume 148, the latest release in the International Review of Neurobiology series, highlights new advances in the field, with this new volume presenting interesting chapters on a variety of timely topics. Each chapter is written by an international board of authors. - Provides the authority and expertise of leading contributors from an international board of authors - Presents the latest release in the International Review of Neurobiology series - Includes the latest information on late aging-associated changes in alcohol sensitivity, inflammation and cognitive decline

It is well established that certain strains of yeasts are suitable for transforming grape sugars into alcohol, while other yeast strains are not suitable for grape fermentations. Recent progress has clearly demonstrated that the sensory profile of a wine is characteristic of each vine cultivated, and the quality and technological characteristics of the final product varies considerably due to the strains which have performed and/or dominated the fermentation process. Because of their technological properties, wine yeast strains differ significantly in their fermentation performance and in their contribution to the final bouquet and quality of wine, such as useful enzymatic activities and production of secondary compounds related both to wine organoleptic quality and human health. The wine industry is greatly interested in wine yeast strains with a range of specialized properties, but as the expression of these properties differs with the type and style of wine to be made, the actualtrend is in the use of selected strains, which are more appropriate to optimize grape quality. Additionally, wine quality can be influenced by the potential growth and activity of undesirable yeast species, considered spoilage yeasts, which cause sluggish and stuck fermentation and detrimental taste and aroma in the wine.

The first International Handbook of Forest Therapy defines the scientific domain of this innovative, evidence-based and timely public health approach. More than 50 authors from around the world are brought together to offer their expertise and insights about forest therapy from a variety of research perspectives. The theoretical discussion of the effects related to the biophilia hypothesis presented here is complemented by research results compiled across the last three decades in the fields of forest medicine and biochemistry from Asia. The book also highlights the latest developments with regards to forest therapy in a number of different countries, ranging from China and Australia to Germany and Austria. The handbook constitutes a major milestone in research in this field. It sets the baseline for forest therapy to be implemented worldwide as a powerful and financially prudent public health practice.

The Mosaic of Autoimmunity: The Novel Factors of Autoimmune Diseases describes the multifactorial origin and diversity of expression of autoimmune diseases in humans. The term implies that different combinations of factors in autoimmunity produce varying and unique clinical pictures in a wide spectrum of autoimmune diseases. Most of the factors involved in autoimmunity can be categorized into four groups: genetic, immune defects, hormonal and environmental factors. In this book, the environmental factors are reviewed, including infectious agents, vaccines as triggers of autoimmunity, smoking and its relationship with rheumatoid arthritis, systemic lupus erythematosus, thyroid disease, multiple sclerosis and inflammatory bowel diseases. An entirely new syndrome, the autoimmune/inflammatory syndrome induced by adjuvants (ASIA), is also included, along with other diseases that are now recognized as having an autoimmune etiopathogenesis. - Highlights the concept of the mosaic of autoimmune manifestations - Includes new visions on unsuspected molecules - Provides updated knowledge to physicians helping patients with autoimmune diseases - Presents thorough, up-to-date information on specific diseases, along with clinical applications

Sex Differences in Cardiovascular Physiology and Pathophysiology is a comprehensive look into the often overlooked and underappreciated fundamental sex differences between men and women and how those differences affect the cardiovascular system. It covers cardiovascular function, anatomy, cell signaling and the development of pathology. With contributions from world-renowned research investigators, this up-to-date reference compiles critical knowledge on cardiovascular sex differences, providing researchers and clinicians with a better understanding of the diagnosis, prevention and treatment of cardiovascular diseases in both men and women. - Identifies the fundamental sex differences in the physiology and pathophysiology of the cardiovascular system - Describes cell signaling pathways involved in sex-associated cardiovascular function and diseases - Puts the sex differences in cardiovascular diseases in the forefront to improve cardiovascular prognoses

This open access book provides a comprehensive examination of the European Landing Obligation policy from many relevant perspectives. It includes evaluations of its impacts at economical, socio-cultural, ecological and institutional levels. It also discusses the feasibility and benefits of several potential mitigation strategies. The book was timely published, exactly at the time where the Landing Obligation was planned to be fully implemented. This book is of significant interest to all stakeholders involved, but also to the general public of Europe and to other jurisdictions throughout the world that are also searching for ways to deal with by-catch and discard issues.

Since 1972, Patterson's Allergic Diseases has been the go-to reference for healthcare practitioners looking for a comprehensive and practical guide to the diagnosis and treatment of allergic disorders. This eighth edition focuses on patient evaluation and management, and covers immunologic mechanisms, pathophysiology, pharmacology, and diagnostic techniques. Many contributors hail from outside the field of allergy-immunology, providing an invaluable non-specialist perspective on essential clinical practices.

'Funzioni e responsabilità del Capo dello Stato nelle giurisprudenze costituzionali'si pone l'obiettivo di offrire al lettore una rivisitazione in chiave sistemica dell'interazione vigente tra le decisioni delle più alte magistrature, chiamate a definire in ultima istanza l'insorgenza di conflitti istituzionali nelle loro diverse accezioni, e gli aspetti evolutivi della carica presidenziale, in modo tale da poter comprendere in che misura e secondo quali linee di tendenza le decisioni delle prime abbiano inciso sullo statuto di responsabilità del secondo condizionandone, inoltre, l'evoluzione all'interno dell'architettura istituzionale, nonché la stessa forma di governo nel suo complesso.

Alzheimer's Disease: New Beginnings focuses on the future promise for therapeutic breakthroughs in light of notable clinical trial failures. The volume editors used a combination of scientometric evaluations to determine the most promising new approaches as well as soliciting insights from leaders in each of the major areas of Alzheimer's disease research. By combining these two approaches, they recruited authors from the entire outlook spectrum, from those who feel an elusive breakthrough might still be a few, well-placed tweaks away to those who feel that they are launching entirely new investigative paradigms. These scholars present an open-eyed path forward. Now is the most exciting period in this field as old dogmas make way for new insights, from new approaches to clinical trials, improved biomarker-based diagnostics, population-based studies, prevention, metabolism, to further refinement of the role of inflammation, genetics, tau, and amyloid-β.

This unique book reveals how Collaborative Innovation Networks (COINs) can be used to achieve resilience to change and external shocks. COINs, which consist of'cyberteams'of motivated individuals, are self-organizing emergent social systems for coping with external change. The book describes how COINs enable resilience in healthcare, e.g. through teams of patients, family members, doctors and researchers to support patients with chronic diseases, or by reducing infant mortality by forming groups of mothers, social workers, doctors, and policymakers. It also examines COINs within large corporations and how they build resilience by forming, spontaneously and without intervention on the part of the management, to creatively respond to new risks and external threats. The expert contributions also discuss how COINs can benefit startups, offering new self-organizing forms of leadership in which all stakeholders collaborate to develop new products.