Search

If there is a complication of paramount importance in the field of maternofoetal health, it is preterm delivery. Defined as the birth of an infant before completing 37 weeks of gestation, preterm delivery stands as a primary contributor to foetal morbidity and mortality and places a major socio-economic burden on health systems. It is therefore undeniable, that preterm birth remains a substantial global health concern and a priority that needs to be addressed from different perspectives. The primary aim of this book is to contribute to a deeper understanding of preterm delivery among healthcare professionals. For this purpose, this compilation gathers the collective knowledge of experts, researchers, and clinicians from diverse disciplines. Their contributions explore various aspects of preterm delivery, examining its causes, risk factors, clinical management, and long-term complications. In this way, the multifactorial nature of preterm delivery is unraveled in the diverse themes explored in this book.

Qu'est-ce qu'un nouveau-né? Quelle est sa place sur la scène juridique? Telles sont les questions auxquelles cet ouvrage a pour ambition de répondre.Au fur et à mesure de la découverte de cette notion, l'étude éprouve les conditions traditionnellement admises pour accéder à la personnalité juridique, et propose de comprendre certaines questions de société selon une nouvelle perspective : gestation pour autrui, réanimation néonatale, fin de vie, naissance en prison…Étudier le nouveau-né, c'est s'intéresser à un être qui n'a aucune autonomie, aucun discernement, qui ne peut pas s'autodéterminer, et surtout qui est dépourvu d'acte de naissance : sa soumission aux adultes est absolue. Le droit doit donc assurer sa protection en limitant cette soumission, ce qu'il ne fait que très imparfaitement.

Gain an understanding of diseases and disorders to effectively assist the Physical Therapist! Goodman and Fuller's Pathology for the Physical Therapist Assistant, 3rd Edition provides a solid background in pathology concepts and how they affect the role of the PTA in client rehabilitation. With an easy-to-read approach, chapters define each disease or systemic disorder, then describe appropriate physical therapy assessments plus guidelines, precautions, and contraindications for interventions. Case studies show how treatment ideas may be applied in everyday practice. From PTA educator Charlene M. Marshall, this market-leading pathology text provides the practical tools required to treat patients knowledgeably and effectively. It also includes a fully searchable eBook version with each print purchase. Concise information on disease processes and systemic disorders provides a background in the underlying pathology of diseases, helping PTAs to ask their patients appropriate questions and to adapt therapeutic exercise programs. Easy-to-follow format is organized to first define each disorder, followed by sections on clinical manifestations and medical management. Chapter objectives, outlines, and vocab builders at the beginning of each chapter introduce the topics and terminology to be presented. Medical Management sections address diagnosis, treatment, and prognosis for each condition discussed. Focus on the Physical Therapist Assistant's role provides the PTA with specific guidelines to the rehabilitation process for patients with diseases and disorders. Special Implications for the PTA sections allow students to easily reference information on working with patients with specific diseases or pathologic conditions. Nearly 800 drawings and photos reinforce student understanding of diseases, conditions, and general pathology principles. Standardized terminology and language is consistent with the Guide to Physical Therapy Practice, familiarizing readers with the standard terminology used in PT practice. Abundance of tables and boxes summarize important points, making it easy to access key information. E-chapters add supplemental information on behavioral and environmental factors, the gastrointestinal system, the reproductive system, lab tests and values, and more. NEW! Updated and revised content throughout provides students with the current information they need to be effective clinicians. NEW! Clinical Pharmacology Spotlight provides an easy-reference summary of the basic pharmacology information for each pathology. NEW! eBook version is included with print purchase. The eBook allows students to access all of the text, figures, and references, with the ability to search, customize content, make notes and highlights, and have content read aloud.

Since publication of the first edition in 2015, neonatal anesthesia and surgery have advanced at lightning speed with many new developments, hence the need to update several essential topics. These include our understanding of neonatal apoptosis, the ever-increasing use of regional anesthesia in neonates, pharmacology of drugs in neonates, the delivery of anesthesia outside the operating room, neonatal resuscitation/guidelines, and perinatal complexities such as the EXIT procedure together with the fundamental principles of developmental physiology, airway management and ventilation as well as perioperative complications and ethical considerations that are unique to this age group. This comprehensive and well-illustrated book is led by Dr. Jerrold Lerman who brings four decades of research, publication and clinical experience in pediatric and neonatal anesthesia. He has amassed a team of recognized international experts in neonatal anesthesia, surgery, and intensive care to share their knowledge in managing neonates for the challenges they face both within and without the surgical suites. Neonatal Anesthesia, the 2nd edition, is the quintessential clinical reference for perioperative care of these small patients that should be read by trainees as well as experienced clinicians and is certain to become an invaluable resource for every anesthetic and critical care department that serves children.Reviews from the 1st edition:“Lerman's book stands alone as an up-to-date text dedicated exclusively to the practice of anesthesia in neonates …. The text covers its subject matter in extraordinary breadth and depth. … Throughout the book there are illustrative and clinically relevant diagrams, nicely supporting and summarizing relevant text for the more visual learner. … Neonatal Anesthesia is a sophisticated but approachable text that offers its readers theory-based practical approaches to understanding and managing anesthesia inour youngest, most fragile patient population.” (Stephanie A. Black and Lynne G. Maxwell, Anesthesiology, Vol. 125 (3), 2016)“It is a long-awaited contribution to the literature, filling a gap of over a decade without a neonatal anaesthesia textbook. … textbook should hold an essential and required spot on the bookshelf of any anaesthetist or critical care physician who cares for neonates. … The reference lists are comprehensive and exhaustive. Dr Lerman should be commended for finally presenting the anaesthesia community worldwide with this textbook, which will be able to stand on its own, probably for the next decade.” (K. P. Mason, British Journal of Anaesthesia, Vol. 116 (4), 2016)“This book covers in 400-plus pages and 17 chapters most of what is known about the neonatal airway, physiology, drugs and anesthetics, with separate chapters on each subcategory of neonatal anesthesia. … Certainly pediatric surgeons, anesthesiologists who only occasionally care for children, students, residents, and fellows will appreciate this book. … This is a large book on a narrow topic that has increasing relevance to the field of current pediatric practice. It is well written, well illustrated, and highly useful.” (Robert M. Arensman, Doody's Book Reviews, April, 2015)“The book has many outstanding chapters that have been thoughtfully crafted by leading researchers in specific fields. … this book is an essential addition to any pediatric anesthesiology library in any organization that provides care to neonates. This book is an excellent resource, not only for anesthesiologists at every level of training and expertise but also for other professionals who provide postoperative care, administer sedative drugs, control the airway, and undertake procedures in newborn infants.” (Carolyne Montgomery and J. Mark Ansermino, Canadian Journal of Anesthesia, Vol. 62, 2015)

This book provides an overview of endocrine diseases associated with alterations of salt metabolism, with a focus on clinical and pathophysiological aspects. It covers various topics in the endocrine control of salt and water homeostasis, such as neuroendocrine determinants of water balance, adrenal hormone biosynthesis, hormonal function in target renal cells, and dysfunction of hormonal target effectors in the kidney. It also features an update on the clinical management of these diseases, including new diagnostic and therapeutic tools. Written by a combination of recognized and emerging experts in the field, this book is intended as a major reference work, not only for endocrinologists and nephrologists, but also for pediatricians, neonatologists, cardiologists, and emergency medicine and intensive care specialists, who can be faced with the management of endocrine diseases responsible of salt and water imbalance. The book is part of the SpringerReference program, which provides access to ‘living editions'that are constantly updated using a dynamic, peer-review publishing process.

Chapter “Aerosol Therapy and Humidification” is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.

Medical and surgical care have made considerable progress in the last two decades in the care of the mother, fetus, and neonate. Most of the improvement in outcomes has been related to advances in diagnostic and therapeutic modalities. These advances have only been possible due to dramatic progress in our knowledge of the physiological mechanisms that determine the normal development of organ systems, as well as the alterations that can lead to disease states and their multifarious consequences. Because improved antenatal care has resulted in the survival of greater numbers of immature infants, they have become a major challenge for clinicians due to the immaturity of multiple organs and their susceptibility to long-term sequelae. The aim of this book is not to address all aspects related to the newborn lung, but to discuss those areas that are more novel or controversial or have been of greater relevance in the progress of maternal, fetal, and neonatal care. Where possible, we have attempted to meet the expectation that practice guidelines be based either on convincing available evidence or on consensus statements of authoritative organizations. Therefore, this book should be useful to obstetricians, perinatologists, and neonatologists.

Viral, Parasitic, Bacterial, and Fungal Infections: Antimicrobial, Host Defense, and Therapeutic Strategies highlight diverse types of infections, including viral, bacterial, parasitic, fungal, and the therapeutic efficacy of antibiotics, antivirals, antifungals and other medications, nutraceuticals, and phytotherapeutics. This book addresses the molecular, pathophysiological, and cellular pathways involved in the process of infection. It also examines the host defense mechanisms modulated by innate and adaptive immunity. The book starts off with an introduction, which includes etiology, pathophysiology, and diagnosis of infections. It then goes on to cover a wide spectrum of salient features involved in viral, bacterial, parasitic, and fungal infections and effective therapeutic strategies. In addition, there is a complete section of eight chapters elaborating the detailed aspects of COVID-19 infections, Mucormycosis, Omicron, and strategic vaccines and therapeutics. The book further goes on to discuss novel antibiotics, vaccines, bromhexine, boron compounds, phytotherapeutics, and aspects on boosting immune competence. Contributed by experts in the fields of viral, parasitic, bacterial, and fungal infections, the book comprehensively details the various types of infections such as herpes and COVID-19, their molecular mechanisms, and treatment strategies for those engaged in the research of infectious diseases. Details the pathophysiology of various classes of infections Examines mechanisms of pathogenesis, immunity, and therapeutics in bacterial, viral, and eukaryotic infectious diseases Discusses various aspects on herpes, COVID-19 infections, Mucormycosis, Omicron, vaccines, and therapeutics Covers the salient features on zoonosis, prion disease, and diabetic foot infections Provides therapeutic strategies of using new antibiotics, vaccines, bromhexine, boron compounds, structurally diverse phytotherapeutics, immune enhancers, and other modalities for treating infections

Written by leading global experts in the field, Principles of Neonatology provides those on the NICU team with clinically focused, evidence-based guidance in an easy-to-access format. Chapters cover the key topics of greatest and most frequent concern to clinicians treating newborns, delivering current, data-driven management and treatment advice in a single source relevant to the seasoned practitioner, fellow, or trainee. A highly templated format makes it easy to find exactly the information you need. Lavishly illustrated with photos, radiographs, drawings, and charts and graphs that clarify key concepts in a helpful and accessible way. Evidence-based focus ensures that only the most reliable treatment protocols and clear-cut, data-driven guidance are included. Coverage of all relevant topics in the NICU: skin lesions, congenital anomalies, architecture/development of neonatal intensive care units, pain control, anesthesia for newborn infants, and much more. Ideal for every member of the NICU team: neonatologists, neonatology fellows, residents, and neonatal nurses, as well as all other clinicians working in the NICU, including PAs, occupational therapists, respiratory therapists, and others.

This excellently illustrated book, now in a revised and extended second edition, not only describes the radiological findings which can be found in child abuse cases but also places them in a forensic perspective – a crucial aspect often underrepresented in radiological books. The aim is to enable physicians involved in non-accidental trauma cases to interpret radiological findings in light of the forensic circumstances under which these findings have arisen. Accordingly, the book will assist in determining whether a fracture is accidental or the result of abuse. Fractures are addressed not only by anatomical location but also by trauma mechanism, with careful attention to evidence regarding the reported mechanism and the clinical outcome. Drawing on the latest literature, the authors explain whether a particular form of trauma can cause a particular injury and identify where the reader can find the supporting evidence. The book will be essential reading and a superb reference for all who are involved in the diagnosis of child abuse, including pediatricians, emergency room physicians, and radiologists. It will also be a valuable resource for legal medicine physicians, lawyers, and judges.

Steroids in the Laboratory and Clinical Practice covers both basic chemistry and therapeutic application of steroids in a single source. The comprehensive reference addresses the specificity of steroid determinations to clarify confusion arising from the laboratory results. The book covers important advancements in the field and is a valuable addition in the literature addressing all existing knowledge gaps. This is a must have reference for pathologists, laboratorians, endocrinologists, analytical/clinical chemists and biochemists. Addresses the normal production of steroids and concentrations found in biological fluids and tissues Presents the changes in steroid concentrations at life events as reference points for clinical investigations Reviews the genetic disorders of steroids in relation to specific enzyme changes and clinical presentation

Developed by a renowned group of international authors, this engaging, case-based title once again offers readers a wide range of thought-provoking case studies that reflect contemporary, challenging, hands-on clinical care. Expanded and fully updated, Endocrinology and Diabetes: A Problem Oriented Approach, 2nd Edition addresses the complete range of endocrinologic problems found in patient care, offering the reader a convenient and pointed way to solve clinical problems in a timely manner. Due to its comprehensive coverage and practical focus, this title has developed a special place in the field of endocrinology and will again be of great interest to endocrinologists, diabetologists, internal medicine physicians, family physicians, fellows, and residents. The enthusiastic reception and warm welcome of the first edition of this book was overwhelming and gratifying. Despite many standard texts that cover physiology and clinical aspects of endocrinology, this book found a special place because it focused on patient care and practical aspects of endocrine practice. In the current volume we were fortunate to again have the honor of collaboration by international authors who pride themselves foremost as clinical endocrinologists. We hope our readers will find this updated, improved edition worthwhile, and use it for the benefit of their patients.

Comprehensive, readable, and clinically oriented, Stoelting's Pharmacology & Physiology in Anesthetic Practice, Sixth Edition, covers all aspects of pharmacology and physiology that are relevant either directly or indirectly to the anesthetic practice—a challenging topic that is foundational to the practice of anesthesia and essential to master. This systems-based, bestselling text has been thoroughly updated by experts in the field, giving you the detailed information needed to make the most informed clinical decisions about the care of your patients.

Essential for ob/gyn physicians, primary care physicians, and any health care provider working with pregnant or postpartum women, Drugs in Pregnancy and Lactation: A Reference Guide to Fetal and Neonatal Risk, 12th Edition, puts must-know information at your fingertips in seconds. An easy A-to-Z format lists more than 1,400 of the most commonly prescribed drugs taken during pregnancy and lactation, with detailed monographs designed to provide the most essential information on possible effects on the mother, embryo, fetus, and nursing infant.

A much-needed overview of the available information now accumulating to indicate that assisted reproductive technologies are generally safe for both babies and mothers. However, the literature abounds with reports of a higher risk of obstetric and perinatal complications; regarding the long term outcomes for both women and children, the data are still scarce. The chapters summarized in this book review the current knowledge on long term safety of assisted reproduction and indicate the need for continued research to cover the lack of data in some specific patient groups and for recently developed treatments that only have a short period of follow-up.

Offering the comprehensive, authoritative information needed for effective diagnosis, treatment, and management of sick and premature infants, Fetal and Neonatal Physiology, 6th Edition, is an invaluable resource for board review, clinical rounds, scientific research, and day-to-day practice. This trusted two-volume text synthesizes recent advances in the field into definitive guidance for today's busy practitioner, focusing on the basic science needed for exam preparation and key information required for full-time practice. It stands alone as the most complete text available in this complex and fast-changing field, yet is easy to use for everyday application. Offers definitive guidance on how to effectively manage the many health problems seen in newborn and premature infants. Contains new chapters on Pathophysiology of Genetic Neonatal Disease, Genetic Variants and Neonatal Disease, and Developmental Biology of Lung Stem Cells, as well as significantly revised chapters on Cellular Mechanisms of Neonatal Brain Injury, Neuroprotective Therapeutic Hypothermia, Enteric Nervous System Development and Gastrointestinal Motility, and Physiology of Twin-Twin Transfusion. Features 1,000 full-color diagrams, graphs and anatomic illustrations, 170+ chapters, and more than 350 global contributors. Includes chapters devoted to clinical correlation that help explain the implications of fetal and neonatal physiology, as well as clinical applications boxes throughout. Provides summary boxes at the end of each chapter and extensive cross-referencing between chapters for quick reference and review. Allows you to apply the latest insights on genetic therapy, intrauterine infections, brain protection and neuroimaging, and much more.

This book comprehensively addresses female and male fertility preservation. It discusses in detail all major aspects of fertility preservation in both sexes, explains the basis of fertility preservation, and highlights the currently available techniques; further chapters are dedicated to specific diseases. The book offers an essential reference guide for all physicians, specialists or not, seeking to improve their grasp of female and male fertility preservation.

This book summarizes the state of cognoscibility regarding normal newborn care that has been accumulated over the past centuries, especially the 20th and now 21st century. The preface/introduction details historical concepts that have followed newborns over the millennia of Homo sapiens sapiens'existence, such as infanticide, breast feeding, swaddling, neonatal resuscitation, and principles of caring for newborns. The mortality rate of newborns has been reduced in many parts of the world in the past two centuries, and we have learned much about how to keep increasing numbers of newborns alive and healthy. This is especially seen when healthcare providers and society collaborate in this important endeavor that includes emphasizing known preventive principles. Current modern pediatric and perinatal treatments allow newborns in the current 21st century America to have a start on an overall life expectancy of 78.5 years (up to 76 years in males and 80.9 years in females) if they receive meticulous medical care, and even if they are born into a penurious state. Such deserved care and inevitable medical discoveries will only lengthen these life trajectories. This second edition updates principles of caring for the newborn that were identified in the first edition. It considers the newborn examination, newborn screening, safe-sleep concepts, mother and newborn skin-to-skin contact, effects of prenatal drug use, mental health issues in the newborn, maternal mood disorders, infant feeding, circumcision, anticipatory guidance, and concepts of surgery in the newborn. Also considered are selective disorders found in some newborns that includes newborn neurology, cardiology, pulmonology, nephrology, gastroenterology, endocrinology and dermatology.

Un ouvrage complet sur les handicaps de l'enfant dans leur prise en charge globale D'incroyables progrès ont été réalisés au cours de ces dernières années permettant d'améliorer la prise en charge, la qualité de vie et le pronostic des enfants et des adolescents porteurs de handicap L'organisation des soins évolue avec la labellisation des centres de référence maladies rares où la pédiatrie occupe une place majeur. Près de 15 ans se sont écoulés depuis la publication de la première édition de cet ouvrage qui a servi de référence à toute une génération de pédiatres et de professionnels de l'enfance. Par son abord très accessible et son ambition de rester au plus près des préoccupations du quotidien, aussi bien en terme de soins qu'au niveau de leur organisation, cet ouvrage n'a pas connu d'équivalent. Il était temps de proposer une nouvelle édition et de faire le tour de tous les aspects de la prise en charge du handicap de l'enfant, avec comme fil conducteur, la spectaculaire amélioration des soins dont bénéficient aujourd'hui les enfants concernés. Cette nouvelle édition aborde autant de thèmes qui mettent en lumière le rôle prépondérant du médecin auprès de l'enfant porteur de handicap et de sa famille. Celui-ci doit s'exercer en concertation avec les autres professionnels de santé, quel que soit le motif de recours au soignant (dépistage, prévention, diagnostic, prise en charge, suivi, etc.) Enfin, un questionnement éthique propre à cet âge de la vie est développé. Le regard d'un enfant, quel qu'il soit, reste une responsabilité majeure, qu'il s'agisse de soins, d'enseignement ou de recherche.

L'endocrinologie du développement est au coeur de l'endocrinologie périnatale. Initiée dès la fécondation, elle se poursuit pendant la vie foetale. Elle permet au nouveau-né de s'adapter à la vie extra-utérine puis à l'enfant de s'épanouir. Chez la femme enceinte, certaines endocrinopathies vont modifier le fonctionnement du système endocrinien foetal et néonatal. Cet ouvrage intègre les différents domaines de l'endocrinologie, les interactions entre les hormones de la mère et du foetus via le placenta, et les pathologies endocriniennes du développement foetal et néonatal. Son originalité réside dans le fait est qu'il est pluridisciplinaire et transversal. Les particularités de la prise en charge diagnostique et thérapeutique des pathologies endocriniennes de la femme enceinte, du foetus et du nouveau-né y sont détaillées. Cet ouvrage intéressera les endocrinologues, obstétriciens, pédiatres, néonatologistes, radiologues, généticiens, chirurgiens et sages-femmes qui interviennent dans le diagnostic prénatal et la prise en charge initiale du nouveau-né.

At the outset of pregnancy, most parents expect a roughly 40-week journey punctuated by the birth of a healthy baby. When a preterm birth upends these expectations, the effects extend beyond the infant; there are real psychological consequences for the parents themselves.Treatment of Psychological Distress in Parents of Premature Infants tackles these issues, shedding light on the high prevalence of symptoms of posttraumatic stress disorder (PTSD) in parents following a premature birth.More than a dozen experts lend their expertise as they examine not only the medical and neurological consequences of premature birth on infants but also recent findings on the psychological effects of premature birth on parents -- including the particular issues that fathers experience, which receive their own chapter.Uniquely, this volume outlines a comprehensive programmatic approach to psychological consultation in the neonatal intensive care unit (NICU). The authors describe how to leverage common interventions -- including trauma-focused cognitive-behavioral therapy -- in innovative ways to reduce symptoms of anxiety, depression, and PTSD in NICU parents.A chapter that focuses on vulnerable child syndrome underscores the implications of failing to address PTSD symptoms on parenting and child development and offers a parent-focused intervention to reduce unhealthy patterns of overprotective parenting.The insights offered throughout the book -- as well as in the complementary online treatment manual -- will position readers to develop an entire program of psychological services, from screening to intervention, in the NICU.

This splendid volume presents numerous aspects of preterm labor and delivery, from its fundamental mechanism to clinically focused approaches. The incidence of preterm delivery is 6-7% in Japan, while globally up to 10% of pregnancies with preterm labor result in premature delivery. The rates of overall survival and intact survival of the premature infants are also excellent in Japan. Thus Japan's approach to preterm labor and delivery has long attracted attention. In each chapter, experts describe specific issues unique to conditions in Japan, including diagnosis, tocolytic agents, definition of clinical chorioamnionitis, treatment of bacterial vaginosis, role of amniocentesis, management of preterm premature membrane rupture and also placental pathology, presenting definitive evidence of the reduced incidence of preterm delivery in Japan. This book benefits not only obstetricians, pediatricians and gynecologist, but also midwives, nurse practitioners, and medical andassociated staffs in the field of obstetrics, pediatrics, as well as neonatal and perinatal medicine who are involved in delivery.

Written by internationally renowned experts, the 3rd edition of this six volume textbook provides detailed practical guidance and advice on the diagnosis and management of the complete range of ocular cancers. Supplying the reader with state-of-the-art knowledge required in order to identify these cancers early and to treat them as effectively as possible, this book is divided into six volumes: Basic Principles, Eyelid and Conjunctival Tumors, Orbital Tumors, Uveal Tumors, Retinal Tumors, and Retinoblastoma. The information presented enables readers to provide effective patient care using the latest knowledge on ophthalmic oncology and to verify diagnostic conclusions based on comparison with numerous full-color clinical photographs from the authors'private collections, histopathologic microphotographs, imaging studies, and crisp illustrations. Clinical Ophthalmic Oncology's clinically focused and user-friendly format allows for rapid retrieval of information in daily practice and is written for residents, fellows, and any physician involved in the care of patients with ocular or orbital malignancies. Additionally, this edition adds several hundred new images to improve comprehension of procedures and techniques. This volume describes the classification, differential diagnosis, and imaging of retinoblastoma and discusses the most suitable treatment options for different tumor types.​

Umfassend und informativ stellen namhafte Experten in diesem Werk das gesamte Spektrum der Reproduktionsmedizin dar. Gynäkologen und Reproduktionsmediziner erhalten praktisch umsetzbares Wissen für die Betreuung und Behandlung von Paaren mit Kinderwunsch, vor allem ungewollt kinderloser Paare. Das Buch führt praxisnah und wissenschaftlich fundiert Schritt für Schritt von den physiologischen Grundlagen der Empfängnis und Sterilität, über diagnostische Methoden hin zu den verschiedenen reproduktionsmedizinischen Techniken. Komplikationen, die während der Therapie auftreten können sowie der Umgang damit werden erläutert. Ebenso sind rechtliche Regelungen in Deutschland, Österreich und der Schweiz dargestellt und kommentiert.

As a capstone of the commemorations of the 40th anniversary of the birth of the first baby conceived by in vitro fertilization (IVF), in 1978, this collection gathers the principal actors of the history of IVF, and summarizes the main achievements, current state, and future prospects of this technique. The contributions here cover, in a historical perspective, all major aspects of IVF, including its indications and techniques, the basic concepts of ovarian stimulation, the cryopreservation of embryos and oocytes, oocyte in vitro maturation, and technical aspects of oocyte retrieval and embryo transfer, among many other topics. The volume not only provides topical information to health professionals, but is written in such a way that it is understandable to the lay public who may read it as a passionate story of the evolution of techniques intimately related to the origin of human life.

This comprehensive, up-to-date reference on surgery in the neonate presents and explains the latest developments in the diagnosis and treatment of neonatal malformations and surgical pathologies. The coverage includes conditions involving the head and neck and the chest, disorders of the liver and biliary tract, gastrointestinal disorders, genitourinary conditions and malformations, anterior abdominal wall defects, tumors, and various other pathologies. For each condition, the pathogenesis and the most current and innovative surgical, and also medical, approaches are described with the aid of numerous illustrations. Minimally invasive strategies receive particular attention, and tips and tricks that will be of value in clinical practice are highlighted. The book includes a general part covering topics such as embryology, anatomy, prenatal diagnosis, and anesthesia and also provides detailed advice on pre- and postoperative care, with special consideration of nutritional problems. Neonatal Surgery will serve as an excellent guide for all pediatric and neonatal surgeons, whether in training or experienced

This landmark book, a reference work now in its second edition, provides healthcare practitioners in neonatology with an up-to-date, comprehensive source of readily accessible practical advice that will assist in the expert management of patients and their diverse illnesses. Leading experts in their fields discuss the underlying causes and mechanisms and all aspects of the treatment of the full range of neonatal diseases and abnormalities, citing the evidence base whenever appropriate. In addition, detailed information is provided on epidemiology and fetal medicine; therapeutic issues such as the organization of care, transport services, and home care after discharge; legal issues; nutrition; and the consequences of medication use during pregnancy, maternal drug abuse and smoking, and maternal diabetes. The inclusion of summaries, tables, and carefully selected guidelines and recommendations will supply practitioners with quick references and instant solutions during daily practice. The book will be a superb resource for all involved in the care of newborn babies, including neonatologists, pediatricians, pediatric surgeons, anesthesiologists, midwives, and nursing staff. It is published within the SpringerReference program, which delivers access to living editions constantly updated through a dynamic peer-review publishing process.

Dr. Richard Polin's Neonatology Questions and Controversies series highlights the most challenging aspects of neonatal care, offering trustworthy guidance on up-to-date diagnostic and treatment options in the field. In each volume, renowned experts address the clinical problems of greatest concern to today's practitioners, helping you handle difficult practice issues and provide optimal, evidence-based care to every patient. Stay fully up to date in this fast-changing field with Nephrology and Fluid/Electrolyte Physiology, 3rd Edition. New chapters on Inherited Disorders of Calcium, Phosphate and Magnesium; Fluid and Electrolyte Management of High Risk Infants; Renal Development and Molecular Pathogenesis of Renal Dysplasia; and Prenatal Programming, which describes how prenatal insults can result in hypertension, kidney and cardiovascular disease. The most current clinical information, including new content on the molecular basis for hereditary tubulopathies and inherited disorders of calcium, phosphate, and magnesium homeostasis. New information on genetics and pharmacology, neonatal hypertension, diuretic use in the newborn, prenatal programming of adult diseases, lung fluid balance, and much more. Consistent chapter organization to help you find information quickly and easily. The most authoritative advice available from world-class neonatologists who share their knowledge of new trends and developments in neonatal care. Purchase each volume individually, or get the entire 7-volume set!Gastroenterology and NutritionHematology, Immunology and GeneticsHemodynamics and CardiologyInfectious Disease and Pharmacology New Volume!Nephrology and Fluid/Electrolyte PhysiologyNeurologyThe Newborn Lung

Dr. Richard Polin's Neonatology Questions and Controversies series highlights the most challenging aspects of neonatal care, offering trustworthy guidance on up-to-date diagnostic and treatment options in the field. In each volume, renowned experts address the clinical problems of greatest concern to today's practitioners, helping you handle difficult practice issues and provide optimal, evidence-based care to every patient. Stay fully up to date in this fast-changing field with Infectious Disease and Pharmacology, an all-new volume in the series. Thorough, up-to-date content on the epidemiology, clinical manifestations, treatment, and outcomes for neonatal-perinatal infections, including necrotizing enterocolitis, neonatal HSV, and congenital Zika virus infection. The latest information on dosing of antibiotics, antivirals, and antifungals. Current coverage of therapies for neonatal gastroesophageal reflux, seizures, neuroprotection, and neonatal abstinence syndrome, as well as pharmacokinetic and pharmacogenetic considerations in neonatal care. Consistent chapter organization to help you find information quickly and easily. The most authoritative advice available from world-class neonatologists who share their knowledge of new trends and developments in neonatal care. Purchase each volume individually, or get the entire 7-volume set!Gastroenterology and NutritionHematology, Immunology and GeneticsHemodynamics and CardiologyInfectious Disease and Pharmacology New Volume!Nephrology and Fluid/Electrolyte PhysiologyNeurologyThe Newborn Lung

This book presents up-to-date knowledge on infertility in the context of polycystic ovary syndrome (PCOS) and provides clear evidence-based guidance on its treatment. The book opens by discussing anovulation, oocyte quality, and the endometrium in women with PCOS, infertility and subfertility cofactors, and the impact of PCOS phenotypes on fertility. All aspects of management are then thoroughly addressed. The available medical treatments for PCOS-related infertility – including antiestrogens, aromatase inhibitors, insulin-sensitizing drugs, and gonadotropins – are reviewed, and other potential therapeutic approaches, such as acupuncture and laparoscopic ovarian drilling, are assessed. Careful attention is also devoted to the role of lifestyle interventions. The use of controlled ovarian stimulation in infertile PCOS patients undergoing intrauterine insemination or in vitro fertilization is examined in detail, as are the benefits of in vitro maturation of oocytes. This book will beof value to all who are involved in the care of women with PCOS and related infertility issues.

Advances in Neurotoxicology, Volume Two, addresses contemporary advances in neurotoxicology, with thematic volumes providing authoritative review articles on key issues in the field. Updates in this new volume include chapters on Air pollution and neurodegenerative diseases, Mercury and Parkinson's disease, Pesticides and PD: current evidence, Aluminum and neurodegeneration, Microglia and neurodegeneration, Dietary factors, Mitochondria in neurodegeneration, and Manganese and neurodegeneration. Edited by leading experts, volumes are designed as in-depth overviews of the latest topic developments that analyze the effect of varied chemical agents on the nervous system. It is an essential resource for researchers and graduate students alike. Includes, in one single publication, a selection of comprehensive reviews devoted to neurotoxicology Edited by high-profile, leading academics in the field, ensuring a quality publication for subscribers Aims to widen the scope for participation by international contributors, researchers and editorial board members outside North America Serves a broad audience of university faculty, researchers and students, as well as the industry, drug development companies and the government

This book provides a detailed guide to neonatal surgery and its related disciplines including: fetal medicine, fetal surgery, radiology, newborn anaesthesia, intensive care, neonatal medicine, medical genetics, pathology, cardiac surgery, and urology. The book aims to cover all the latest advances in newborn surgery, with contributions from the basic sciences and laboratory research to reflect the steady progress in our current working knowledge and understanding of many neonatal surgical disorders. As huge advances have been made in neonatal surgery in the past decades, ethical issues, long term outcomes, and quality of life are also emphasised. This book is an authoritative reference for surgical residents in training, consultant surgeons, general surgeons with an interest in paediatric surgery, neonatologists, paediatricians, intensive care specialists, and nursing staff.

This book examines the role of Neonatal Intensive Care Units (NICUs) and follow-up clinics in addressing the complex developmental, behavioral, social, and medical needs of at-risk infants through early intervention and medical subspecialties. It describes the necessary functional components of follow-up clinics and challenges in establishing and running multidisciplinary clinics in an area of difficult heath care financing. Chapters provide essential guidelines for determining which neonates will need follow-up care, evaluating for neurodevelopmental delays and medical and behavioral impairment and disability, and estimating how long intervention and further follow-up will be required. Chapters also discuss organization, staffing, funding, testing protocols, and coordination with other programs and care facilities, particularly early intervention and the medical home. In addition, the book offers best practices for fostering optimal development for individual infants and high-risk populations while raising standards for neonatal care and creating a smooth transition to appropriate subsequent care. Topics featured in this book include: Developmental care in the nursery. Utilizing neonatal brain imaging to predict neurodevelopmental outcomes of NICU infants.Genetic considerations in infants with congenital anomalies.The HRIF clinic organization model.Issues common in neurodevelopmental testing of premature infants.The impact of environmental risks, such as parental distress and in-utero drug exposure, to infant neurodevelopment. Follow-Up for NICU Graduates is a must-have resource for researchers, practitioners, and graduate students in developmental psychology, pediatrics, neuroscience, obstetrics, nursing, and related disciplines.

An ideal reference for infertility specialists and reproductive endocrinologists alike, this comprehensive text discusses current natural and mild approaches to in vitro fertilization (IVF) and the development of in vitro maturation (IVM) as a clinical treatment. It is divided thematically into four sections. Part I presents the basic science of ovarian endocrinology and the mechanism of oocyte maturation, including follicular development and the importance of mitochondrial changes. The differences between natural cycle IVF and stimulated IVF are presented in part II, including the standard ovarian stimulation protocols and their outcomes and the etiology, prevention and management of ovarian hyperstimulation syndrome (OHSS). Minimal and mild stimulation for IVF is discussed in part III, including mild stimulation protocols for oncofertility patients and the new minimally invasive INVO procedure. In vitro maturation as a clinical treatment is the subject of part IV, discussing the methodology of immature oocyte retrieval as well as other laboratory aspects and congenital and obstetrical outcomes of babies born from IVM. Combining expertise from thought leaders around the world, Development of In Vitro Maturation for Human Oocytes will be a go-to resource for infertility researchers and practitioners and reproductive endocrinologists working with infertile couples looking for safer and more cost-effective options for treatment.

The new edition of this text admirably fills the need for a primer on the central topics involved in Human In Vitro Fertilization (IVF). Supplying a comprehensive and hands-on approach to IVF, this source presents established state-of-the-art procedures and techniques, as well as the most current research in the field. Expert contributors also discuss the history of IVF and the potential of future research. Offering essential information for reproductive endocrinologists, IVF practitioners and embryologists, this book guides readers though every step of human assisted conception, from patient pre-treatment to monitoring of outcomes.

In vitro fertilization (IVF) and other assisted reproductive technologies (ART) have become a significant part of human reproduction, with already one in 50 children worldwide being born through ART and the demand steadily increasing. To accommodate the various kinds of infertility problems, new methods have been developed to increase IVF and ART success rates and it has also become possible to treat sperm, eggs, and embryos in culture to improve reproductive success, to increase the health state of an embryo, and to prevent disease in the developing child. Human Reproduction: Updates and New Horizons focuses on recent developments and new approaches to study egg and sperm cells and embryo development, as well as addressing the increasing demand for IVF and ART to overcome infertility problems of various kinds that are encountered by an increasing number of couples worldwide. The book includes 10 chapters written by experts in their specific fields to provide information on sperm selection techniques and their relevance to ART; In vitro maturation of human oocytes: current practices and future promises; Molecular biology of endometriosis; Novel immunological aspects for the treatment of age-induced ovarian and testicular infertility, other functional diseases, and early and advanced cancer immunotherapy; Mitochondrial manipulation for infertility treatment and disease prevention; Novel imaging techniques to assess gametes and preimplantation embryos; Clinical application of methods to select in vitro fertilized embryos; New horizons/developments in time-lapse morphokinetic analysis of mammalian embryos; The non-human primate model for early human development; Cytoskeletal functions, defects, and dysfunctions affecting human fertilization and embryo development. This book will appeal to a large interdisciplinary audience, including researchers from both the basic science and medical communities. It will be a valuable reference for IVF clinicians, patients and prospective patients who are considering ART procedures, embryologists, cell biologists and students in the field of reproduction.

This book provides guidance to all professionals working with children who present with injuries, neglect, illness falsification and other forms of child abuse. Clinical findings and the current literature are analyzed. The author's clinical experience is shared to assist the reader in diagnosing the cause of injury and other presentations. This text is the result of many years of experience in the UK working with children in an East London hospital (which receives over 1000 children a week through the children's Emergency Department) and the analysis of over 400 cases for the Family and Crown Courts. Mainstream opinions, the medical literature, and examples from extensive experience on the wards and in Court are discussed. Pediatric Forensic Evidence is aimed at doctors, lawyers, the Courts, social workers, health visitors, teachers, the police and others, guiding them through the analysis of injury and when to raise concerns.

After 30 years, Obstetrics: Normal and Problem Pregnancies remains your go-to choice for authoritative guidance on managing today's obstetric patient. International experts put the latest knowledge in this specialty at your fingertips, with current and relevant information on everything from fetal origins of adult disease, to improving global maternal health, to important topics in day-to-day obstetrical practice. Highly readable, well-illustrated, and easy to understand, this bestselling obstetrics reference is an ideal tool for residents and clinicians. Take advantage of the collective wisdom of global experts in the field, including two new editors— Drs. Vincenzo Berghella and William Grobman -- and nearly 30 new contributors. Gain a new perspective on a wide range of today's key issues - all evidence-based and easy to read. Sweeping updates throughout including four new chapters: ‘Vaginal Birth after Cesarean Delivery'; ‘Placenta Accreta'; ‘Obesity'; and ‘Improving Global Maternal Health: Challenges and Opportunities'11 videos reinforce chapter content and enhance learning in areas such as cesarean delivery and operative vaginal delivery New Glossary of the most frequently used key abbreviations for easy reference Expanded use of bolded statements and key points as well as additional tables, flow diagrams, and bulleted lists facilitates and enhances the mastery of each chapter More than 100 images in the Obstetrical Ultrasound chapter provide an important resource for normal and abnormal fetal anatomy

Put essential information at your fingertips – before you prescribe. The updated 11th edition of Drugs in Pregnancy and Lactation: A Reference Guide to Fetal and Neonatal Risk lists more than 1,200 commonly prescribed drugs taken during pregnancy and lactation, with detailed monographs that provide the information you need on known or possible effects on the mother, embryo, fetus, and nursing infant. For the 11th edition, this bestselling reference has two new authors, both highly knowledgeable on the effects of drugs on the embryo-fetus and nursing infant: Craig V. Towers, a maternal-fetal medicine specialist, and Alicia B. Forinash, a clinical pharmacologist specialist in obstetrics.

Dieses Buch zeigt Neonatologen, Pädiatern, Geburtshelfern, Kinderkrankenschwestern und Hebammen wie die intensivmedizinische Versorgung von Früh- und Neugeborenen adäquat gelingt. Der Klassiker im Kitteltaschenbuchformat erscheint bereits in der 9. Auflage. Diese ist komplett aktualisiert und zugunsten noch größerer Praxisnähe gekürzt. Viele Tipps und Tricks helfen Fallstricke und Gefahrensituationen zu erkennen und somit zu vermeiden. Ein praxisorientiertes Buch, auf hohem wissenschaftlichem Niveau zum schnellen Nachschlagen und kompetenten Handeln bei schwerkranken Früh- und Neugeborenen.Aus dem InhaltBeatmung, Blutgasanalyse und SauerstofftherapieErnährung, Flüssigkeits-und ElektrolytbilanzDiagnostik und Therapie pulmonaler, kardialer, renaler und neurologischer ErkrankungenVermeiden, Erkennen und Behandeln von KomplikationenGrenzen der NeugeborenintensivmedizinPharmakotherapie des Neugeborenen

This first-of-its-kind volume addresses the myriad of issues relating to—and reviews the plethora of responses to--premature births in the United States, both in national context and compared with other countries. In addition to current clinical data, it examines how preterm births in the U.S. fit in with larger social concerns regarding poverty, racial disparities, reproductive rights, gender expectations, and the business of health care. Comparisons with preterm birth phenomena in Canada, the U.K., and other Western European countries illustrate cultural narratives about motherhood, women's status, differences across social welfare and abortion policies, and across health care financing and delivery sytems, and how these may affect outcomes for newborns. The book sorts out these intersecting complexities through the following critical lenses: · Clinical: causes, treatments, and outcomes of preterm birth · Population: the distribution of preterm births · Cultural: how we understand preterm birth · Health care: delivering care for high-risk pregnant women and preterm infants · Ethical: moral decision-making about preterm birthsPreterm Birth in the United States synthesizes a wide knowledge base for maternal and child health professionals across diverse disciplines, including public health, social work, nursing, medicine, and health policy. Social scientists with interests in reproduction and gender issues will gain access to historical, clinical and epidemiological knowledge that can support their work. There is also an audience for the book among childbirth activists such as supporters of midwifery and less medicalized childbirth.

This unique title is designed to illustrate and foster how a closer working relationship between pediatricians and subspecialists can make childhood medicine work more seamlessly. Despite the common lack of training for pediatricians in pediatric neurosurgery, they are challenged almost daily with caring for children with neurologic conditions. Common Neurological Conditions in the Pediatric Practice is replete with a wide range of instructional case vignettes and is organized into sections that loosely approximate the neurologic development of a child and address issues that are commonly encountered. The first section reviews neurologic development and birth related trauma commonly seen in the neonatal intensive care unit. The second part addresses findings commonly encountered by a pediatrician in a child's first month of life. The third section is a comprehensive review of hydrocephalus. Part four describes state of the art imaging techniques for the central nervoussystem in children, from pre-natal ultrasound through MRI and CT; and the fifth part consists of individual explorations of common neurosurgical conditions that many pediatricians are uncomfortable managing, including brain tumors, spasticity, and vascular lesions to use as a reference tool when caring for a complex neurosurgical patient. Finally a series of chapters related to head trauma, including sections on non-accidental trauma and concussion management, completes the text.

Textbook of postgraduate psychiatry (2 volumes) is assimilated with all modern developments in psychiatry and their effects on clinical practice. Textbook of Postgraduate Psychiatry is addressed primarily to the postgraduate student in psychiatry and allied mental health fields, but it should equally serve as a good source of revision and reference to psychiatrists, who have already completed their training, and to practitioners and clinicians, and other mental health professionals. This book is divided into two volumes, which are further divided into 22 sections following as clinical examination in psychiatry and epidemiology of mental disorder, organic mental disorder and substance related disorders, schizophrenia, other psychotic disorders and mood disorder, anxiety disorders, stress related disorders, psychosomatic medicine, somatoform disorder, dissociative disorder and other related disorders, personality disorder, sexual disorder, sleep disorder and eating disorders, pregnancy and menstruation related disorders, liaison psychiatry, neuropsychiatry, psychiatric aspect of medical disorders and other related conditions, emergency in mental health, child and adolescent psychiatry, basic sciences and imaging in psychiatry, neuropsychology, research methods, statistics and genetics in psychiatry, biological therapies, psychological methods of treatment, culture, spirituality, anthropology and psychiatry, community psychiatry and psychiatric nursing, and forensic psychiatry and mental health legislation. These 22 sections cover the 82 chapters. It is also a best reference book for established practitioners across the world. The contributors include renowned authorities in the various subspecialties of psychiatry with original work to their credit as well as young, zealous psychiatrists, who are actively involved in academic life.

Alpha-fetoprotein (AFP) has many applications across various disciplines. This oncofetal protein is routinely used by clinicians for antenatal testing as well for the screening and treatment monitoring of certain malignances. Innovative research using AFP has also been very promising. Recent developments include the use of AFP or its recombinant fragments for drug delivery to cancer cells, as well as for the engineering of cancer vaccines and T cell immunotherapies. The anti-estrogenic potential of AFP has also been utilized to develop drugs directed against estrogen receptor positive malignancies. This book is divided into five sections. In Section One, the history of AFP is recollected, and the role of AFP in normal and pathological conditions is explored. Section Two and Three focus on the utility of AFP during pregnancy. In Section Two, the use of routine maternal serum AFP screening for detection of chromosomal aneuploidies and neural tube defects in normal pregnancies and pregnancies with pre-existing disease is discussed; the potential use of AFP for the detection of preeclampsia is also reviewed. Section Three explores the pathogenesis and data linking unexplained elevations of AFP to adverse obstetrical outcomes. Section Four presents chapters that discuss AFP ligand binding, receptor targeting, and drug delivery strategies. Finally, Section Five serves to explain the regulatory roles of AFP, its use in immunotherapy, and in the development of cancer vaccines. The aim of this book is to bring together some of the great research and clinical insights that currently surround AFP. The target audiences for this book are basic science researchers as well as clinicians.

Fetal & Neonatal Physiology provides neonatologist fellows and physicians with the essential information they need to effectively diagnose, treat, and manage sick and premature infants. Fully comprehensive, this resource continues to serve as an excellent reference tool, focusing on the basic science needed for exam preparation and the key information required for full-time practice. The 5th edition is the most substantially updated and revised edition ever. In the 5 years since the last edition published, there have been thousands of publications on various aspects of development of health and disease; Fetal and Neonatal Physiology synthesizes this knowledge into definitive guidance for today's busy practitioner. Offers definitive guidance on how to effectively manage the many health problems seen in newborn and premature infants. Chapters devoted to clinical correlation help explain the implications of fetal and neonatal physiology. Allows you to apply the latest insights on genetic therapy, intrauterine infections, brain protection and neuroimaging, and much more. Expert Consult eBook version included with purchase. This enhanced eBook experience allows you to search all of the text, figures, images, and references from the book on a variety of devices. Features a fantastic new 4-color design with 1,000 illustrations, 170+ chapters, and over 350 contributors. 16 new chapters cover such hot topics as Epigenetics; Placental Function in Intrauterine Growth Restriction; Regulation of Pulmonary Circulation; The Developing Microbiome of the Fetus and Newborn; Hereditary Contribution to Neonatal Hyperbilirubinemia; Mechanistic Aspects of Phototherapy for Neonatal Hyperbilirubinemia; Cerebellar Development; Pathophysiology of Neonatal Sepsis; Pathophysiology of Persistent Pulmonary Hypertension of the Newborn; Pathophysiology of Meconium Aspiration Syndrome; Pathophysiology of Ventilator Dependent Infants; Pathophysiology of Hypoxic-Ischemic Brain Injury; Pathophysiology of Neonatal White Matter Injury; Pathophysiology of Meningitis; Pathophysiology of Preeclampsia; and Pathophysiology of Chorioamnionitis. New Pathophysiology of Neonatal Diseases section highlights every process associated with a disease or injury, all in one place. In-depth information, combined with end-of-chapter summaries, enables deep or quick use of the text.

For the gold-standard resource on pediatric fractures, reach for Rockwood and Wilkins'Fractures in Children. Written by leading orthopaedic surgeons from around the world, the revised and expanded 8th edition of this classic bestselling text presents complete, up-to-date coverage of all types of children's fractures. A must-read for pediatric orthopedic surgeons and orthopedic residents.

Written by internationally renowned experts, Clinical Ophthalmic Oncology provides practical guidance and advice on the diagnosis and management of the complete range of ocular cancers. The book supplies all of the state-of-the-art knowledge required in order to identify these cancers early and to treat them as effectively as possible. Using the information provided, readers will be able to provide effective patient care using the latest knowledge on all aspects of ophthalmic oncology, to verify diagnostic conclusions based on comparison with numerous full-color clinical photographs, and to locate required information quickly owing to the clinically focused and user-friendly format. In this volume, all aspects of the diagnosis, histopathology, genetics and treatment of retinoblastoma are discussed in detail.

Drugs in Pregnancy and Lactation is an A-Z listing of drugs by generic name. Each monograph is a careful and exhaustive summary of the literature as it relates to drugs and their known or possible effects to the fetus in pregnancy and to the baby through lacation. Each monograph is templated to include generic US name, Pharmacologic class, Risk factor, Fetal risk summary, Breast feeding, and References. This edition includes access to the entire contents of the book, which will be updated quarterly, initially.

New Quality and Safety chapter addresses quality care for the neonatal/pediatric patient. New Clinical Highlights boxes discuss realistic scenarios to help you apply your knowledge to clinical practice. UPDATED! Over 400 full-color illustrations — plus clear tables and graphs— make it easier to visualize key concepts. New! Key point summary at end of each chapter highlights essential content in a bulleted format. New! Glossary provides easy access to key terms and their definitions. New! Key terms at the beginning of each chapter highlight important terminology.

Sixième édition, entièrement réécrite et augmentée de l'ouvrage de référence en Médecine interne depuis plus de trente ans.Ce traité est aujourd'hui édité pour la première fois intégralement en couleur.L'équipe d'une centaine d'auteurs, tous référents dans leur spécialité, a révisé et actualisé l'ensemble des chapitres.Sont développées de façon complète et précise : l'inflammation, l'immunité, la génétique et l'anatomopathologie ; les maladies auto-immunes ; les vascularites ; les manifestations et affections systémiques ; les maladies systémiques en pédiatrie ; les autres affections systémiques (GVH, DIP, etc.) ; les thérapeutiques (depuis les immunosuppresseurs jusqu'aux biothérapies).La richesse de l'iconographie en couleur, les tableaux, les bibliographies et l'index détaillé ajoutent à la qualité et à l'exhaustivité de ce traité, devenu un classique.