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Colorectal cancer is the third most commonly diagnosed condition in oncology, affecting around 1.23 million individuals per year, according to recent statistics. Of these patients, about 50% will develop liver metastases and approximately 20% will present a stage IV disease at diagnosis. These statistics make colorectal liver metastases (CLM) an issue of major importance in current oncology. The area of CLM is subject to great and continuous advances, as its pathophysiologic mechanisms are better understood and more therapeutic and surgical options are developed. Consequently, all professionals involved with the diagnosis, treatment and follow up of CLM should be kept up to date with the latest advances on the field, to provide high standard medical care to their patients. This book is designed to present the state-of-the-art in CLM management and, in doing so, to review the current evidence on CLM, discussing all important topics in the field. Coverage is broad and comprehensive, encompassing introductory topics (history, definitions, epidemiology, etc.), basic science subjects (molecular biology, genetics, dissemination process, etc.) and practical clinical topics (tumor behavior, diagnosis, drug therapy, radiation therapy, surgery, ablation, multidisciplinary teams, etc.). Although comprehensive on the coverage and selection of topics, each chapter is concise and objective, dissecting topics in a practical and direct format. Evidences and recommendations are included. Chapters display a brief introduction of the common knowledge, go straight to the detailed revision of the most recent years of the literature, and end with practical closing observations. This book is a tool for professionals (general and cancer surgeons, HPB surgeons, clinical oncologists, gastroenterologists and medical residents) and interns who search for a qualified and reader friendly revision on topics concerning Colorectal Cancer Liver Metastases.

This book is designed to present a practical and evidence-based approach to liver and pancreas surgery that will provide both experienced and novice surgeons as well as surgical trainees a resource for optimizing their outcomes. The entire perioperative spectrum of care is addressed in chapters written by an international panel of experts in the field. Initial sections discuss preoperative assessment and intervention, fluid management, and perioperative pain control. Subsequent chapters focus on the specific aspects of operative approach and technique, including minimally invasive surgery, fluid management, parenchymal transection, and use of drains, tubes and stents. The text concludes with chapters on perioperative pain control, management of complications as well as the role of enhanced recovery pathways. A brief review of the existing literature addressing the particular topic follows in each section. Extensive illustrations, figures, and tables provide reinforcement to the educational content. Optimizing Outcomes for Liver and Pancreas Surgery will provide readers an easy to reference guide with easily accessible text and visual aids.