1. Frontiers in Protein Structure Research.
- Author
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Simon, Istvan, Magyar, Csaba, and Simon, Istvan
- Subjects
Biotechnology ,Technology: general issues ,B.1.1.7 ,B.1.617.2 ,C1q ,CASP ,CO2 concentrating mechanism ,COVID-19 ,E484Q ,FK506-binding protein ,FKBP12 ,FKBP51 ,GalNAc ,GlcNAc ,Keap1 ,Li-Fraumeni syndrome ,N501Y mutation ,NMR ,Neu5Ac ,Nrf2 ,OTOL1 ,ProSPr ,Shannon information entropy ,T478K and L452R mutation ,UBA5 ,UFC1 ,UFM1 ,alphafold ,amino acid composition ,analytical ultracentrifugation ,bidirectional long-short term memory ,bifidobacteria ,calcium binding proteins ,circular dichroism ,co-translational protein folding ,coarse-grained modeling ,complex structure ,configurational entropy ,conserved domains ,contact ,convolutional neural network ,cysteine reactivity ,dataset ,deep learning ,deep sequencing ,diffusion-ordered NMR spectroscopy ,distance ,electrospray ionization mass spectrometry ,energy-dependent protein folding ,entropy ,erythrocyte membrane ,erythrocytes ,force fields ,free energy ,free energy landscape ,fucose ,fucosidases ,galactose ,genetic variation ,germline TP53 missense variants ,glucose ,glucuronate ,glutathione ,glutathionylation ,glycosyl hydrolases ,hereditary breast cancer ,high hydrostatic pressure ,homotetramer ,human milk ,hydrogen/deuterium exchange ,iduronate ,inter-subunit interaction ,intrinsically disordered ,intrinsically disordered proteins ,manganese ,mannose ,mass spectrometry ,metalloprotein ,molecular chaperones ,multiscale modeling ,mutual synergetic folding ,n/a ,nitrosylation ,nuclear magnetic resonance spectroscopy ,otoconia ,otolin-1 ,oxidative folding ,oxidative stress ,phosphorylation ,photosynthesis ,physical model of protein folding ,prediction ,protein ,protein conformation ,protein dynamics ,protein folding ,protein-ligand interactions ,protein-protein binding ,protein-protein complex ,protein-protein interactions ,quantitative prediction model ,residue packing ,retardants ,retrainable ,ribosomal exit tunnel ,saturation mutagenesis ,site-directed mutagenesis ,small-angle X-ray scattering ,solvent accessibility of peptide bonds ,solvent-accessible surface area ,spike protein ,tetrabromobisphenol A ,tetrabromobisphenol S ,tetrahydropyran ,thermal shift assay ,thermodynamic stability ,transient complex ,transmembrane proteins ,xylose ,α-helical bundle - Abstract
Summary: In this Special Issue, we aim to represent the vibrant state of protein structure studies at the end of 2021. Recent decades have brought significant changes to the protein structure research field. Thanks to the genome projects and advances in structure determination methods, the number of solved protein structures has increased significantly. Protein structure research is experiencing a new renaissance, and in 2020 the number of deposited structures in the PDB database reached a new record. An assortment of many new frontiers are presented in this collection. A single Special Issue cannot give a comprehensive overview of a large field such as proteins science, but we aim to give a broad overview of current research.