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Safety pharmacology is the evaluation and study of the pharmacological effects of a potential drug that are unrelated to the desired therapeutic effect. These effects often present a hazard-particularly in individuals with compromised or limited organ system functions. This volume covers safety pharmacology from the regulatory requirements down to the studies that must be done to justify them. Using the author's more than 30 years of direct experience, the book incorporates tricks and practical insights for making studies work and understanding why they fail.

Organisms, both aquatic and terrestrial, are sources of a wide variety of substances, many of which have already been shown to be bioactive. They play a wide variety of physiological and environmental roles. These chemicals include a broad array of proteins, lipids, and polysaccharides. Many of these natural products find applications in industry,

This reference presents a detailed overview of approaches and techniques in the management of pain caused by tissue, nerve and central nervous system injuries, categorizing pain into a variety of syndromes and underlying mechanisms to aid the development of interventional pharmacologic measures.