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This open access book is a groundbreaking exploration of systemic risk in modern financial systems. Through its theoretical and empirical investigations, it reveals the multidimensionality of systemic risk, the transmission channels of crises, and the interlinkages between physical, transition, and financial risks. It introduces cutting-edge methodologies, including prediction and optimization models based on complex networks, multilayer networks and eXplainable Artificial Intelligence (XAI) approaches, to forecast and measure systemic risk and financial crisis. It provides insight for academics, practitioners, policy and supervisory authorities, and bankers and financial market operators on understanding the links that determine the propagation of financial crises and the emergence of systemic risks. This book is essential for those wishing to better understand systemic risk and its implications.

Biological evolution is the phenomenon concerning how species are born, are transformed or disappear over time. Its study relies on sophisticated methods that involve both mathematical modeling of the biological processes at play and the design of efficient algorithms to fit these models to genetic and morphological data. Models and Methods for Biological Evolution outlines the main methods to study evolution and provides a broad overview illustrating the variety of formal approaches used, notably including combinatorial optimization, stochastic models and statistical inference techniques. Some of the most relevant applications of these methods are detailed, concerning, for example, the study of migratory events of ancient human populations or the progression of epidemics. This book should thus be of interest to applied mathematicians interested in central problems in biology, and to biologists eager to get a deeper understanding of widely used techniques of evolutionary data analysis.

The research and development process in modern drug discovery and development is a complex and challenging task. Using traditional biological test methods such as PCR to measure the expression levels or function of these genes is costly and time-consuming. RNA-seq can measure the expression patterns of thousands of genes simultaneously and provide insights into functional pathways or regulations in biological processes, which has revolutionized the way biological scientists examine gene functions. This book addresses the various aspects of the RNA-seq technique, especially its application in drug discovery and development.Features• One of the few books that focuses on the applications of the RNA-seq technique in drug discovery and development.• Comprehensive and timely publication which relates RNA sequencing to drug targets, mechanisms of action, and resistance.• The editor has extensive experience in the field of computational medicinal chemistry, computational biophysics, and bioinformatics.• Chapter authors are at the frontline of the academic and industrial science in this particular area of RNA sequencing.

El consumo de cannabis en España es significativo, involucrando a personas de entre 15 y 64 años. En 2022, el 40,9% de los españoles había probado el cannabis alguna vez, y el 10,6% lo consumió en los últimos 12 meses. Aunque el consumo ocasional es estable, el consumo diario aumentó del 1,7% en 2007 al 2,8% en 2022. Los jóvenes de 15 a 24 años muestran una mayor prevalencia, con un 22,6% reportando consumo en el último año. El consumo es más común entre hombres (14,4%) que entre mujeres (6,8%). En 2022, el 1,9% de la población de 15 a 64 años (aproximadamente 600.000 personas) tuvo un consumo problemático de cannabis. Sin embargo, entre aquellos que han consumido cannabis en los últimos 12 meses y han contestado la escala CAST, la prevalencia de consumo problemático se sitúa en el 21,5%.En 2021, 12.338 personas iniciaron tratamiento por abuso o dependencia de cannabis, la mayoría hombres y muchos menores de 18 años. Las urgencias hospitalarias relacionadas con el consumo de cannabis no médico aumentaron, representando el 44,5% de los episodios de urgencia en 2021. De los 6.209 episodios de urgencias por sustancias psicoactivas, el cannabis estuvo involucrado en el 44,5% y la cocaína en el 40,3%. Este incremento ha sido notable desde 1996.El presente libro investiga cómo se ha llegado a este punto, señalando el papel de los movimientos pro-legalización y la industria del cannabis en la propagación del consumo. Estos movimientos, respaldados por la industria, han difundido la idea de que el cannabis tiene beneficios terapéuticos y que su consumo recreativo es inofensivo, lo cual es un mensaje engañoso que ha calado especialmente entre los jóvenes.El presente compendio está dividido en tres secciones y 18 capítulos, redactados por expertos en conductas adictivas. Proporciona un análisis basado en la evidencia científica más reciente sobre el consumo de cannabis, abarcando su incidencia desde una perspectiva epidemiológica y de salud pública, así como su tratamiento clínico-terapéutico. Además, se exploran las complejidades del consumo desde una perspectiva de género, ofreciendo una visión completa del fenómeno en la sociedad contemporánea.

Apotropaia and Phylakteria: Confronting Evil in Ancient Greece is the outcome of the conference held in Athens in June 2021 and hosted by the Swedish Institute at Athens. The belief in the existence of evil forces was part of ancient everyday life and a phenomenon deeply embedded in popular thought of the Greek world. Fear of such malevolent powers generated the need for protection and we find clear traces of these concerns in both textual and archaeological sources. From the beginnings of literature, there is mention of ghosts and other daemonic beings that needed appeasement, and of ways of repulsing evil, such as the use of baskania and antibaskania (apotropaia). Repeatedly, we meet rituals of an apotropaic or prophylactic character conducted as part of everyday and family life, as for example on the occasion of a birth, marriage or death in the oikos (the cleansing of the house and household, libations and sacrifices in honour of oikos ancestors), and other practices that focused on the protection of the community as a whole, i.e. the Pharmakos ritual. Archaeology reveals an abundance of material objects thought to have the power to attract benevolent, and avert evil, forces. Traces of ritual practices necessary to ensure prosperity and avert personal disaster are manifest today in the form of amulets, certain semi-precious stones believed to protect women and children, eye-beads found in large numbers in many archaeological assemblages, possibly various types of terracotta figurines, such as nude female grotesques and various ithyphallic characters, to name a few. In addition, symbols and certain iconographic motifs, such as the phallus, the open hand, the Gorgoneion, images of triple Hekate, and Hermes, have been subject to a number of differing interpretations relative to apotropaic power.

L'opera Natürliche Schöpfungsgeschichte, qui presentata in traduzione, fu redatta dallo zoologo tedesco Ernst Haeckel sulla base della trascrizione di un ciclo di lezioni tenute all'Università di Jena nel semestre invernale 1867-1868, rivolte a un pubblico non specializzato. Qui Haeckel riprende, in un linguaggio piano e semplice, le tesi espresse nella Generelle Morphologie der Organismen, opera poderosa, pubblicata in due volumi nel 1866. Un brillante riassunto divulgativo, sul quale lo stesso Darwin espresse il proprio apprezzamento nell'introduzione al The Descent of Man (1871) e che vantò ben undici edizioni e numerose traduzioni, fra le quali la meritevole traduzione in lingua italiana del 1892, curata da Daniele Rosa e con prefazione di Michele Lessona. Il presente volume propone una nuova traduzione italiana della prima parte dell'opera (costituita da quindici conferenze), dedicata al confronto con noti pensatori e scienziati dell'epoca e, in particolare, con coloro che Haeckel definisce i “padri fondatori della teoria della discendenza”: Darwin, Goethe e Lamarck.

In contrast to non-financial firms, banks have undergone significant turbulence in the past decade, enduring severe financial crises and unprecedented regulatory reforms. New regulations, including heightened capital and liquidity requirements, measures to address regulatory migration, resolution authority, stress testing, and capital planning, have spurred the development of new tools to manage institutional failure. The primary goal has been to reduce the likelihood of poor performance and improve stock market valuations to restore public confidence in the industry. The banking industry plays a vital role in global economic and financial stability and is subject to intense regulatory and market scrutiny. Financial instability can be very costly for banks due to its spillover effects on other parts of the economy. Therefore, a sound, stable, and healthy financial system is essential for efficient resource allocation and risk distribution across the economy.This is the first book that comprehensively addresses a range of contemporary issues in the global banking industry, providing a thorough understanding of the challenges and opportunities faced by the sector. The book examines how banking business models, effective policies, and regulations can address these issues, covering corporate governance, asset-liability management, risk management, financial performance, and regulatory frameworks. The potential benefits of alternative banking models, including Islamic banking, and their contribution to global financial stability and resilience are also explored.Contributions from international scholars using both quantitative and qualitative methods provide new insights, recent findings, and perspectives on future bank stability and resilience in a global context. The book also presents updated evidence and debates on the impact of recent regulations and governance structures on the industry, which has undergone significant changes in response to financial turmoil and new laws and regulations aimed at enhancing bank resiliency, protecting against systematic risks, and promoting fair and ethical banking practices.

Meanings are realized at the point of reception and this volume intends to offer an in-depth discussion of some of the meanings associated with and raised by the figure of Telamonian Ajax at various, specifically contextualized, and yet somehow connectable ‘points of reception'. Part 1 looks at how, and from where, and with what effects, the epic and tragic figure of Ajax is constructed and re-defined in archaic and classical Greece. Part 2 moves on to Roman Ajax(es), evaluating how he is used in and by Latin literature as a tool for window-references and innovation, and for reflecting on national identity and cultural categories. Part 3 discusses various ways in which the myth of Ajax, especially in its Sophoclean version, has been translated into theatrical, psychological, and philosophical discussions. This is not an attempt to look for Ajax's true nature (an ill-posed question in itself). Nor is it a claim to evaluate Ajax's features as if they could be placed on a straight evolutionary line (they never can be). On the contrary, the volume provides a multiform and interconnected ensemble of relevant patterns, always particularly situated, and constantly changing.

This book contains the proceedings of the 18th Social Simulation Conference (SSC) and covers the state of the art of social simulation modeling. The SSC is the annual conference of the European Social Simulation Association (ESSA) and the major global conference devoted to this topic. It is aimed at promoting social simulation and computational social science. The book is the biggest collection of agent-based modeling research. It covers all aspects of modeling, from theory and philosophy of modeling to question of model design, purpose, and structure, using data, visualization, model interrelation, and open modeling. This book is targeted at researchers in social simulation regardless of disciplinary backgrounds, across career stages and different sectors, such as academia, industry, and policy

This book presents research findings on newly discovered pests and diseases that may be impacted by climate change in the tropics; current management techniques including molecular diagnostics, integrated pest management (IPM), and agroecological approach; and recent technological advancements used as preventive and curative approaches to mitigate the effects of plant pests and diseases. Combining the expertise of leading researchers in the various fields, the book provides a useful reference for all relevant stakeholders. The proposed book is prepared with the aim of disseminating the current research development of emerging pests and diseases in the tropics in the era of climate change as well as new and eco-friendly pest and disease management technologies of tropical crops. The book is divided into three parts with sixteen chapters. Part 1: Advances in Tropical Insect Pest Management consists of five chapters describing the discovery, formulations, and applications of nature-based solutions such as natural enemies of insects, insect hormones, botanicals, and microorganisms for sustainable pest management. Part 2: Advances in Tropical Plant Disease Management consists of seven chapters, describing the causal agents of economically important diseases of tropical crops, rapid pathogen detection systems as well as effective and sustainable disease management strategies. Part 3: Advances in Other Tropical Pests Management consists of four chapters detailing the various eco-friendly pest management of vertebrates, mollusks, weeds, and emerging IR4.0 technologies in pest management. Ideas for future volumes on this subject: Volume II would be a follow-up to Volume I. It covers emerging pests and diseases of the tropics in greater depth, with a focus on specific hosts and diseases. Robust pests and disease management technologies utilized in crop protection in tropical areas by the farmers will be discussed as well.

Ancient religion is traditionally understood in terms of myths, rituals and institutions, as transmitted in ancient texts. The studies gathered here focus instead on the lived experience of ancient cult and the places in which that experience was formed. They build on recent explorations of Lived Ancient Religion and also on new approaches to Material Ancient Religion. All ancient societies constructed elaborate sanctuaries. Their architecture and the collective rituals that took place there shaped collective experiences. Through case studies drawn from Ancient Egypt, the Greek World and the Roman Empire these themes are explored and elaborated. Together they indicate new ways of approaching ancient religious experience, collective and individual.

Microbial Diversity in the Genomic Era, Second Edition presents techniques used for microbial taxonomy and phylogeny, along with their applications and respective strengths and challenges. Though many advanced techniques for the identification of unknown bacterium are available in the genomic era, a far fewer number of the total microbial species have been discovered and identified to date. With that in mind, this book incorporates recently developed biosystematics methods and approaches to assess microbial taxonomy, with suitable recommendations for where to apply them across the range of bacterial identification and infectious disease research. Here, international researchers in the field first provide a broad overview of microbial genomics research and microbiome directed medicine, followed by sections on molecular tools for microbial diversity research, extremophilic microbial diversity, functional microbial diversity across application areas, microbial diversity and infectious disease research, and future directions for research. Step-by-step methodologies are provided for key techniques, along with applied case studies breaking down recent research studies into the practical components, illuminating pathways for new studies across the field. This new edition has been fully updated to address advances in the field of microbiome directed medicine, and whole genome sequencing for studying microbial diversity, considering both recent technological advances and new applications areas, from extremophile studies to the latest approaches in human microbiome analysis. - Instructs in techniques used for microbial taxonomy and phylogeny, with discussions of their applications and respective pros and cons - Reviews the evolving field of microbial typing and the genomic technologies that enable comparative metagenomic analysis of complex microbial environments - Covers microbiome directed translational research, as well as whole genome sequencing for studying microbial diversity, with newly added research protocols and case studies - Reviews future applications in the field of microbiome directed medicine - Features chapter contributions from global experts in the field

Deep Learning in Genetics and Genomics vol. 1, Foundations and Applications, the intersection of deep learning and genetics opens up new avenues for advancing our understanding of the genetic code, gene regulation, and the broader genomics landscape. The book not only covers the most up-to-date advancements in the field of deep learning in genetics and genomics, but also a wide spectrum of (sub) topics including medical and clinical genetics, predictive medicine, transcriptomic, and gene expression studies. In 21 chapters Deep Learning in Genetics and Genomics vol. 1, Foundations and Applications describes how AI and DL have become increasingly useful in genetics and genomics research where both play a crucial role by accelerating research, improving the understanding of the human genome, and enabling personalized healthcare. From the fundamentals concepts and practical applications of deep learning algorithms to a wide range of challenging problems from genetics and genomics, Deep Learning in Genetics and Genomics vol. 1, Foundations and Applications creates a better knowledge of the biological and genetics mechanisms behind disease illnesses and improves the forecasting abilities using the different methodologies described. This title offers a unique resource for wider, deeper, and in-depth coverage of recent advancement in deep learning-based approaches in genetics and genomics, helping researchers process and interpret vast amounts of genetic data, identify patterns, and make discoveries that would be challenging or impossible using traditional methods. - Brings together fundamental concepts of genetics, genomics, and deep learning - Includes how to build background of solution methodologies and design of mathematical and logical algorithms - Delves into the intersection of deep learning and genetics, offering a comprehensive exploration of how deep learning techniques can be applied to various aspects of genomics

This open access book unveils the hidden elite of Italy's third sector, offering a rare glimpse into the lives and minds of civil society's most influential leaders. Bridging elite and civil society studies, it presents pioneering research on these powerful yet understudied figures. Through in-depth analysis, the chapters reveal surprising insights about the elite's composition, attitudes, career trajectories, and views on power. Essential reading for scholars of democracy, civil society, and social policy, this volume challenges conventional wisdom about leadership in the nonprofit world. By illuminating the dynamics of Italy's third sector elite, it reshapes our understanding of civil society's role in modern democracies.

This book offers a clear account of timelessness together with the discussion of temporality in fundamental physics and cosmology. The multi-disciplinary approach to the problem of time and timelessness shows the remarkable difference between pre-relativistic debates and current developments. This book thoroughly discusses notions of timelessness and time emerging in the most recent literature on Quantum Gravity, String Theory and Cosmology. The contributions explore, among many aspects, the historical-philosophical roots of the notions of temporality and atemporality, the role of mathematics in defining time and temporality with respect to both order relations and causality, approaches to quantum gravity and cosmology that make use of quantum fluids and condensate to approximate space–time in general relativity, time and timelessness in black holes and the problem of cosmological time in bouncing cosmologies. The novelty of this volume lies in the interaction among scientists, philosophers, and historians in exploring the nature of time and timelessness and the origin of these concepts. The book represents a valuable toolkit for researchers and graduate students in physics, cosmology, philosophy and the history of those fields.

Dieses Buch umfasst und beschäftigt sich mit den jüngsten Fortschritten und modernsten Anwendungen von naturinspirierten Computertechniken (NIC) im Bereich der Bioinformatik und der Computerbiologie, die die medizinischen Wissenschaften bei verschiedenen klinischen Anwendungen unterstützen können. Dieser Sammelband befasst sich mit den grundlegenden Anwendungen, dem Umfang und den Zukunftsperspektiven von NIC-Techniken in der Bioinformatik, einschließlich der Erstellung von Genomprofilen, der Klassifizierung von Genexpressionsdaten, der DNA-Berechnung, der System- und Netzwerkbiologie, der Lösung von Komplikationen bei personalisierten Therapien, der antimikrobiellen Resistenz bei bakteriellen Krankheitserregern und der computergestützten Entwicklung von Arzneimitteln, deren Entdeckung und Therapie. Darüber hinaus wird die Rolle von NIC-Techniken bei verschiedenen Krankheiten und Störungen behandelt, einschließlich Krebserkennung und -diagnose, Brustkrebs, Erkennung von Lungenkrankheiten, Krankheits-Biomarkern und Identifizierung potenzieller Therapeutika.

Paper-based Optical Chemosensors comprehensively discusses the origin, development, and current state-of-the-art in paper-based sensors. With a focus on the principles, classifications, methodology, design, and application of paper-based sensors, this book represents a developing research field with recent innovative applications resulting in a comprehensive presentation of the different physico-chemical techniques using paper sensors. It discloses underlying rules and factors in paper-based sensors and discusses intricate sensing systems and working environments by ways of chemistry and physics for a variety of application scenarios such as environmental protection, food safety, public safety, and clinical diagnosis. This is a valuable resource for researchers who major in analytical chemistry, or for those who are interested in the development of methods or devices for rapid analysis/monitoring based on paper/membrane-based sensors who wish to broaden their knowledge in the allied field. - Presents a comprehensive discussion on the current state, challenges, and future perspectives of paper-based optical chemosensors - Offers discussions on the classification, methodology, design, and application of paper based sensors - Provides opportunities for readers to design paper based sensors with specific purpose and deeper awareness

This book presents the select papers from the International Symposium on “Emerging Trends in Synthesis and Catalysis” (ETSC 2023). It covers the latest trends in novel synthesis strategies and highly efficient heterogeneous/homogeneous catalytic chemical species. Various topics covered in this book are green synthesis, reaction designs, catalyst synthesis, advanced materials for organic synthesis, polymer synthesis, stereoselective synthesis, flow chemistry, bio-catalysis, organo-catalysis, catalysis for sustainable development and industrial processes, multiphase catalysis, separation science and process development, organometallic compounds in synthesis and catalysis, computational tools for synthetic processes and processes for environment sustainability. The book is useful for researchers, academicians, and industrialists working in material science and industrial chemistry.

Bone Histology: A Biological Anthropological Perspective, Second Edition builds on the success of the first edition, recognizing the significant advances that have occurred in bone biology, histology, and histological techniques and methods in subsequent years. Bones and teeth are of considerable importance for anthropological and related research, due to their nature as hard tissues. The physical remains of humans available to biological anthropologists, bioarchaeologists, paleopathologists, and paleontologists are, with exception to forensic anthropology, limited to skeletal material; fortunately, the same characteristics of hard tissues that lead to their persistence after death make them a storehouse of information about biological processes experienced during the life of the individual. This book covers important aspects of bone biology which underlie the microstructure of hard tissues that are crucial for histological analysis. This includes an overview of two major metabolic processes, bone remodelling and modelling, and their importance for understanding and interpreting bone histomorphology. Subsequent chapters apply histological methods to the biological profile, such as estimation of age and evaluation of pathological conditions that affect the skeleton, or to determine whether remains are human or nonhuman. Finally, there is a discussion of current research trends in bone histology, with a focus on technological advances in imaging and methods. Reviews of four well-documented skeletal collections—developed specifically for bone histological and imaging research—are discussed, as well as, the importance of such collections for future research. Bone Histology, Second Edition has assembled a collection of contributing authors, with extensive experience and expertise in various aspects of hard tissue biology, to provide readers with an overview of the current state of research and potential applications of histological analysis in biological anthropology, forensic anthropology, and skeletal biology. It serves as a valuable resource for students, researchers, and practitioners in these and related disciplines.

The field of biology and technology is constantly changing and growing. However, the abundance and intricacy of biological data present significant challenges for researchers, educators, and students. Deciphering this vast sea of information to extract meaningful insights can be difficult. Traditional approaches often fail to provide comprehensive solutions to these intricate problems, leaving many struggling to navigate the complexities of bioinformatics. Effective Techniques for Bioinformatic Exploration brings new clarity to the world of bioinformatics, offering a comprehensive solution to the challenges scholars face. Through its meticulously crafted chapters, this book provides a structured approach to understanding and applying bioinformatics principles. Bridging the gap between theory and practice equips readers with the tools needed to tackle complex biological problems effectively. Whether delving into genomics, proteomics, or machine learning models, this book offers a roadmap for success. This book empowers readers to overcome challenges and make meaningful contributions to the field by embracing the scientific method and showcasing the practical application of bioinformatics techniques.

This book is a comprehensive coverage of the ubiquitin-proteasome system and its involvement in cancer progression, and the application of PROTACs in different types of cancer treatment. The book discusses a unique perspective and comprehensive knowledge of the potential of PROTACs to transform cancer therapies. It provides an overview of the history, mechanisms, chemistry, design considerations, and different technologies involved in PROTACs. Additionally, it explains the ubiquitin-proteasome system, its impact on various diseases, and the principles and mechanisms of UPS. The book also describes the chemistry and design aspects of PROTACs and their role in various types of cancers. Finally, it covers the pharmaceutics aspect of formulation design, global requirements, and toxicological aspects of PROTACs. This book is targeted at cancer researchers, medical oncologists, bioinformatics, computational biologists, pharmacologists, medicinal chemists, formulation scientists, regulatory authorities, and policy makers.

River Flow 2022 includes the keynote lecture and contributed papers presented at River Flow 2022, the 11th International Conference on Fluvial Hydraulics (8-10 November 2022, Kingston and Ottawa, Canada; held virtually).River Flow 2022 provides an overview of the latest experimental, theoretical and computational findings on fundamental river flow and transport processes, river morphology and morphodynamics, while covering also issues related to the effects of hydraulic structures on flow regime, river morphology and ecology; sustainable river engineering practices (including stream restoration and re-naturalization); and effects of climate change including extreme flood events. The book presents the state-of-the-art in river research and engineering, and is aimed at academics and practitioners in hydraulics, hydrology and environmental engineering.

Guide to Plant Single-Cell Technology: Functional Genomics and Crop Improvement summarizes the current status of single-cell technology in plants involving food and energy crops. Presenting methods and applications of emerging high-throughput technologies performed using the single-cell platform it includes an emphasis on single-cell RNA sequencing and eventually towards single-cell omics, which are highly complementary and effective for profiling the plant cell subject to either environmental factors or pathogenic threats. These technologies can advance the exploration of plant physiology as well as precision crop breeding for future anti-stress and high-yield plants and achieve sustainable agriculture. The book covers crop improvement and breeding strategies involving single-cell technology to produce future stress-tolerant and high-yield plants, which have better performances on growth, and development to achieve enhanced production of foods and biomass. Guide to Plant Single-Cell Technology: Functional Genomics and Crop Improvement will be a valuable reference resource for academics and researchers in plant and crop sciences. - Focuses on plant molecular profiling using single-cell technology and the integration with functional genomics - Discusses the current methods and challenges of single-cell RNA sequencing in plants - Summarizes the emerging findings of plant single-cell technology - Presents advanced high-throughput technologies for plant omics

Plato's Timaeus is unique in Greek Antiquity for presenting the creation of the world as the work of a divine demiurge. The maker bestows order on sensible things and imitates the world of the intellect by using the Forms as models. While the creation-myth of the Timaeus seems unparalleled, this book argues that it is not the first of Plato's dialogues to use artistic language to articulate the relationship of the objects of the material world to the world of the intellect. The book adopts an interpretative angle that is sensitive to the visual and art-historical developments of Classical Athens to argue that sculpture, revolutionized by the advent of the lost-wax technique for the production of bronze statues, lies at the heart of Plato's conception of the relation of the human soul and body to the Forms. It shows that, despite the severe criticism of mimēsis in the Republic, Plato's use of artistic language rests on a positive model of mimēsis. Plato was in fact engaged in a constructive dialogue with material culture and he found in the technical processes and the cultural semantics of sculpture and of the art of weaving a valuable way to conceptualise and communicate complex ideas about humans'relation to the Forms.

'Mecanismos Moleculares das Doenças e a Atividade Física'é um livro que aborda de forma completa os fundamentos moleculares das doenças e a importância da atividade física na sua prevenção e tratamento. Desde os conceitos básicos da biologia molecular até a prescrição individualizada de exercícios, este livro explora a relação entre os mecanismos moleculares das doenças e a atividade física, destacando seus benefícios para a saúde. O livro é dividido em seções que abrangem os principais mecanismos moleculares envolvidos na fisiologia do exercício e na patologia das doenças crônicas, as evidências científicas que sustentam a relação entre atividade física e saúde, e a prescrição individualizada de exercícios para prevenção e tratamento de doenças. O leitor aprenderá sobre como o exercício pode modular diferentes vias moleculares envolvidas no desenvolvimento de doenças, incluindo a inflamação, a disfunção mitocondrial e a apoptose. Com base nesses conhecimentos, o livro apresenta uma abordagem prática para a prescrição de exercícios, levando em consideração a individualidade de cada pessoa e as particularidades de cada doença. Serão apresentadas estratégias para a prescrição de exercícios para diferentes grupos populacionais. Esta obra é uma leitura essencial para estudantes e profissionais da área da saúde que buscam aprofundar seus conhecimentos sobre os mecanismos moleculares das doenças e o papel da atividade física na promoção da saúde.

As per the reports of FAO, the human population will rise to 9 billion by the end of 2050 and 70% of more food must be produced over the next three decades to feed the additional population. The breeding approaches for crop improvement programs are dependent on the availability and accessibility of genetic variation, either spontaneous or induced by the mutagens. Plant breeders, agronomists, and geneticists are under constant pressure to expand food production by employing innovative breeding strategies to enhance yield, adaptability, nutrition, resistance to biotic and abiotic stresses. In conventional breeding approaches, introgression of genes in crop varieties is laborious and time-consuming. Nowadays, new innovative plant breeding techniques such as molecular breeding and plant biotechnology, supplement the traditional breeding approaches to achieve the desired goals of enhanced food production. With the advent of recent molecular tools like genomics, transgenics, molecular marker-assisted back-crossing, TILLING, Eco-TILLING, gene editing, CRISPR CAS, non-targeted protein abundant comparative proteomics, genome wide association studies have made possible mapping of important QTLs, insertion of transgenes, reduction of linkage drags, and manipulation of genome. In general, conventional and modern plant breeding approaches would be strategically ideal for developing new elite crop varieties to meet the feeding requirement of the increasing world population.This book highlights the latest progress in the field of plant breeding, and their applicability in crop improvement. The basic concept of this 2-volume work is to assess the use of modern breeding strategies in supplementing conventional breeding toward the development of elite crop varieties, for obtaining desired goals of food production.

Advances in next-generation technology (NGS) coupled with a deep understanding of cancer biology have promoted the rational design of target therapy towards precision oncology. Artificial Intelligence (AI)-integrated machine learning techniques are also increasingly used today to tackle the challenges of scalability and high dimensionality data and to transform multiomics data into clinically actionable knowledge. AI tools are used to support clinical decision making and improve clinical efficiency, while delivering safe and high value care. This book provides comprehensive analysis of such techniques and advancements of AI-based clinical cancer research in the improvement of cancer prognosis and diagnosis, resulting in enhanced prediction rates and survival of cancer patients.

Encyclopedia of Sleep and Circadian Rhythms, Second Edition, Six Volume Set is the most comprehensive work on sleep and circadian rhythms. This completely revised new edition, comprised of contributions from 450 renowned authorities in the field, covers what is new and known in the field. In addition to thorough coverage of the basics (physiology, sleep disorders etc.), this new edition includes a thorough examination of circadian rhythms that manage the sleep-wake cycle. Although this area is highly intertwined with sleep, it is a scientific discipline in and of itself, and will broaden the appeal of this work to health care providers and scientists. Other sections of interest explore consumer wearable devices to track sleep and circadian rhythms, artificial intelligence algorithms to detect sleep and abnormal sleep-related conditions, and new technology to treat sleep and circadian rhythm disorders. This book will be an ideal and primary reference resource for students, trainees, technologists, basic/clinical scientists, physicians, advanced practice providers, psychologists, nurses, and other medical and research personnel who want to explore any topic within the sleep and circadian rhythm field. - Provides the largest, most comprehensive publication in the field of sleep and circadian rhythms for non-specialists and readers from undergraduate level upwards, as well as advanced health care providers - Covers the latest, most up-to-date knowledge regarding sleep and circadian rhythms and contains material that reflects the newest technology in the field - Presents a new edition of the winner of the 2013 Prose Award for Multivolume Reference in Science from the Association of American Publishers - Includes rich illustrations that can be used as teaching aids, along with multimedia

This book provides the opportunity to explore the variety of meanings, undertones and contextual connotations that currently pertain to the expressions of'virtual (or digital) restoration'and'reconstruction'. The book focuses on the latest applications of virtual restoration and reconstruction in different areas of Cultural Heritage through the presentation and discussion of several case studies. The goal is to provide a broad perspective on the subject. The sample presented in this book has been indeed selected and evaluated referring to different disciplinary fields such as archaeology, architecture, and conservation while encompassing a variety of cultural and chronological contexts.

This book covers various aspects of cancer chemoprevention, including an overview of chemoprevention in the process of tumorigenesis; the roles of various phytochemicals, functional foods, and dietary interventions in disease prevention; and techniques such as cancer stem cell targeting, nano-formulations, and so forth. The nutrigenomic and epigenetic effects of natural products at the molecular and genetic levels are also covered alongside their potential for additive and synergistic effect, as well as overcoming drug resistance. The key selling features of the book are as follows: Discusses holistic and comprehensive areas of chemoprevention Includes diverse techniques, such as cancer stem cell targeting, nano-formulations, and nanotechnology-based drug delivery systems Introduces various mechanisms involved in prevention of the diseases, including targeting cancer stem cells Reviews various aspects which can reduce the toxicity and cost of treatment of diseases by alternative medicine Explores various sources, mechanisms, and ways to develop cancer chemopreventive agents with minimal toxicity compared to traditional cancer therapy drugs This book is focused on researchers and graduate students in drug delivery and formulation, nanobiotechnology, cancer chemoprevention, prevention, and therapeutics.

Advances in Applied Microbiology, Volume 123 continues the comprehensive reach of this widely read and authoritative review source in microbiology. Users will find invaluable references and information on a variety of areas relating to the topics of microbiology. - Contains contributions from leading authorities in the field - Informs and updates on the latest developments in the field of microbiology - Includes discussions on the role of specific molecules in pathogen life stages, interactions, and much more

This third edition of Medicinal Chemistry of Anticancer Drugs, provides an updated resource for students and researchers from the point of view of medicinal chemistry and drug design, focusing on the mechanism of action of antitumor drugs from the molecular level, and on the relationship between chemical structure and chemical and biochemical reactivity of antitumor agents. Antitumor chemotherapy is a very active field of research, and a huge amount of information on the topic is generated every year. This new edition includes updated sections on the hot topic of cancer immunotherapy, cancer polypharmacology, multitargeted cancer therapy, medicinal chemistry of cancer diagnosis, theranostic anticancer agents, and pre-mRNA processing in cancer. Although many books are available that deal with clinical aspects of cancer chemotherapy, this book provides a unique and valuable perspective from the point of view of medicinal chemistry and drug design. It will be useful to undergraduate and postgraduate students of medicinal chemistry, pharmacology, biological chemistry, pharmacy and other health sciences. Researchers and practitioners will find a comprehensive treatment of the topic and a large number of references to reviews and the primary literature. - Provides a resource that is organized consistently based on targets and mechanisms of action from a molecular point-of-view - Focuses on the relationship between chemical structure and chemical and biochemical reactivity of antitumor agents, providing a rationalization on the action of these type of drugs and the design of new active structures - Features a large number of color figures which give information in a clear-and-concise way - Includes extensive references to review articles and primary literature - Includes updated sections on the hot topic of cancer immunotherapy, cancer polypharmacology, multitargeted cancer therapy, medicinal chemistry of cancer diagnosis, theragnostic anticancer agents, and pre-mRNA processing in cancer

The emergence of fungicide resistance is a major challenge facing agriculture. With increasing regulation and costs limiting the development of new fungicides, farmers remain reliant on a relatively small group of working fungicides, many of which are decreasingly effective as major crop disease pathogens develop resistance to them.Understanding and minimising fungicide resistance provides an authoritative review on the wealth of research on understanding the development of fungicide resistance in agricultural crops and the establishment of preventative measures which can be implemented to limit its spread and the consequent impact of disease on yields. This collection includes ways of understanding and preventing resistance to key groups of fungicides, such as SBI, Qol, SDHI and OSPBI.

Encyclopedia of Cell Biology, Second Edition, a Six Volume Set, has established itself as a fundamental reference work, providing broad coverage of the field in four main sections (Molecular, Organizational, Functional, Translational and Pathological Aspects of Cell Biology). This second edition revisits and expands each section, with entries on topics not covered in the first edition, including Crispr. The whole work is updated, providing greater coverage of specialized cell function and translational applications, and putting greater emphasis on these topics in graduate/medical teaching. New overview chapters and subsections provide a simplified cell biology text that can be used by instructors. The new version includes a standard template for each chapter, making the content easier to navigate, as well as inserts and graphics which provide summaries of key points in each chapter. - Provides the authority of a team of outstanding scientists in the field - Presents a comprehensive, up-to-date resource, covering both basic and translational aspects of cell biology - Offers high quality content at a competitive market price

Through a rich selection of reference entries, country profiles, and interviews, this two-volume set introduces students and general interest readers to the fascinating and multifaceted fields of global and cross-cultural health studies.The health challenges facing people around the world today are diverse, yet we all share common needs for physical, psychological, and social well-being. It is these factors that drive the study and mission of global health.Wellness around the World: An International Encyclopedia of Health Indicators, Practices, and Issues serves as a broad introduction to the field of global health. Volume 1 includes a collection of accessibly written entries covering a wide variety of integral topics in this multidisciplinary subject. Readers will discover how various factors interact with one another to form a complex and multilayered picture of health around the world. Volume 2 features profiles of every country on Earth, detailing each nation's unique health landscape and pressing health concerns. These profiles, which follow a standardized format, allow readers to compare and contrast multiple countries and regions. This set also includes a collection of 10 in-depth interviews with researchers and activists working to improve health around the globe, offering readers a look at how abstract concepts and principles are applied to foster real-world change.

Prostate cancer (PCa) is among the most diagnosed cancers in men worldwide as well as one of the most common causes of cancer-related deaths. Despite the advances in treatment, the disease remains associated with poor survival and resistance to cytotoxic and targeted therapies. Therapy Resistance in Prostate Cancer: Mechanisms and Insights highlights the main mechanisms that are responsible for therapy resistance in PCa allowing researchers and clinicians to have a synopsis of current options and new therapies that can be proposed to overcome this resistance. Understanding the mechanisms responsible for chemotherapy resistance helps researchers all over the world to delve deeper into the pathways behind this resistance and potentially discover new therapeutic targets for PCa. - Tackles the topic of resistance from a broader perspective, including, but not limited to, the role of the extracellular matrix and cancer stem cells in therapy resistance - Creates understanding on how to develop novel therapies that specifically target CSCs to eliminate the regenerating capacity of the tumor and overcome therapy resistance - Helps in identifying novel molecular biomarkers and potential therapeutic targets pertaining to the tumor microenvironment to overcome therapy resistance - Provides a general view of the main pathways involved in PCa progression that will aid in understanding the mechanisms responsible for chemotherapy resistance

How did the Greeks and Romans perceive rape? How seriously was it taken, and who were seen as its main victims? These are two central questions that Rape in Antiquity: Sexual Violence in the Greek and Roman Worlds (1997), edited by Susan Deacy and Karen F. Pierce, aimed to approach in twelve chapters. Setting out to understand if the ancients had a concept of rape and how it was understood through different angles – including legal, social, cultural and historiographical – Rape in Antiquity made an invaluable contribution to the scholarship on sexual violence in the ancient world, impacting upon the development of new approaches in the decades that followed its publication. Revisiting Rape in Antiquity: Sexualised Violence in Greek and Roman Worlds maps out the influence of Rape in Antiquity while exploring how far cultural changes since the 1990s have reshaped the scholarly landscape. This collection, comprising chapters by established scholars and early career researchers from many countries, provides a new window into sexual – and sexualized – violence. Covering a long chronology, this book journeys from Homer to Byzantium, to modern receptions, to the analysis of wartime rape, ancient Greek tragedy, classical myth, how stories involving rape are retold for children, ancient law and rhetoric, classical art, Ovid, Late Antiquity, modern literature, comic books and cinema. This book is the culmination of a rich scholarly inheritance, setting out new perspectives that will hopefully inspire researchers for decades to come.

This thematic volume comprises 30 articles by 44 specialists and is the first collection solely dedicated to the study of Amphoras of the Phoenician-Punic world. The articles take their lead from presentations at a conference held in Ghent in December 2016. It is a welcome update to the terrain covered more than a quarter-century ago by the highly influential monograph of Juan Ramon, Las anforas fenicio-punicas del Mediterraneo Central y Occidental (Col-leccio Instrumenta 2), Barcelona: 1995. The link between trade and the Phoenician and Punic World is so pronounced that these subjects have often been treated synonymously. It is, therefore, hardly surprising that'the Amphora, the key element of the trade in foodstuffs during Antiquity, has been considered the guide fossil for Phoenician and Punic trade'. Geographically, the present contributions cover the space from the Levantine coast to the Atlantic shores of the Iberian Peninsula. Chronologically, they range from the earliest moments of the Phoenician presence in the western Mediterranean during the ninth century BCE until the centuries following the destruction of Carthage and its empire. Thematically, the volume deals with issues of production, typology, distribution, contents, and even socio-economical aspects. As such, it may be considered as a true state of the art on the Amphoras of the Phoenician and Punic World.

Il volume è dedicato da amici e colleghi alla compianta Sara Santoro, che è stata una archeologa di fama ed una studiosa poliedrica, che ha insegnato a Bologna, Parma e Chieti e ha lavorato alacremente in Italia, Francia ed Albania. Il testo presenta una serie di contributi che sono organizzati in sei sezioni, che corrispondono ai principali interessi di Sara e che sono editi dai suoi colleghi presso l'Università G.d'Annunzio di Chieti-Pescara. La prima sezione, Semata, Schemata and Topoi, è a cura di O.Menozzi ed è dedicata a studi iconografici, filologici e di Storia dell'Arte. La seconda parte, a cura di S.Antonelli, è dedicata a contributi e ricerche sull'Adriatico. La terza sezione, che è incentrata su ricerche e studi sul campo, è stata curata da M.Moderato. M.C. Mancini cura la quarta sezione su valorizzazione e progettazione nei Beni Culturali. La quinta sezione, a cura di M.C.Somma, è dedicata ai cosiddetti ‘centri minori'e analizza ruolo e network di tali insediamenti. La sesta sezione è incentrata su metodologie e scienze applicate ai Beni Culturali ed è curata da V.La Salvia.

Big Data technologies have the potential to revolutionize the agriculture sector, in particular food safety and quality practices. This book is designed to provide a foundational understanding of various applications of Big Data in Food Safety. Big Data requires the use of sophisticated approaches for cleaning, processing and extracting useful information to improve decision-making. The contributed volume reviews some of these approaches and algorithms in the context of real-world food safety studies. Food safety and quality related data are being generated in large volumes and from a variety of sources such as farms, processors, retailers, government organizations, and other industries. The editors have included examples of how big data can be used in the fields of bacteriology, virology and mycology to improve food safety. Additional chapters detail how the big data sources are aggregated and used in food safety and quality areas such as food spoilage and quality deterioration along the supply chain, food supply chain traceability, as well as policy and regulations. The volume also contains solutions to address standardization, data interoperability, and other data governance and data related technical challenges. Furthermore, this volume discusses how the application of machine-learning has successfully improved the speed and/or accuracy of many processes in the food supply chain, and also discusses some of the inherent challenges. Included in this volume as well is a practical example of the digital transformation that happened in Dubai, with a particular emphasis on how data is enabling better decision-making in food safety. To complete this volume, researchers discuss how although big data is and will continue to be a major disruptor in the area of food safety, it also raises some important questions with regards to issues such as security/privacy, data control and data governance, all of which must be carefully considered by governments and law makers.

The book delves into post-genomics advances in potato improvement since the potato genome sequencing in 2011. It includes recent developments in the field of potato genetic resources, genes and SNP markers discovery, and the progress in next-generation breeding applying various omics technologies and modern sequencing tools. It covers cutting-edge technologies in potato - a global perspective, genome sequencing and resequencing of various cultivated and wild species, potato germplasm management and characterization, prebreeding genomics, genome mapping and gene cloning, markers discovery, marker-assisted selection, transgenics, microRNAs, transcriptomics, proteomics, metabolomics, phenomics, next-generation potato breeding technologies including genome editing and genomic selection and bioinformatics applications in the post-genomics era in potato. As genome editing and genomic selection have become emerging tools in crop improvement including potato, several research works have been demonstrated and applied world over. This book concentrates on genomics-aided characterization of germplasm and markers discovery to accelerate potato breeding. Further, various omics technologies strengthen our understanding ondiscovery of new genes/proteins/metabolites and key traits based on high-throughput phenotyping involved in various biotic and abiotic stresses in potato crop. The book is a useful source of information related to genomics-led research and development of this crop. It will serve as a valuable resource for potato researchers working in the area of molecular biology and would be beneficial for college students, PhD scholars, scientists, academicians, farmers and policy makers.

Che cos'è, oggi, un classico? Quali opere vengono definite tali nel nuovo millennio, da chi e per chi? Gli autori antichi ci parlano ancora, sulla scena come al cinema, nei fumetti o nei videogiochi. Negli ultimi vent'anni anzi sono protagonisti di un vero boom: usati, legittimati, contestati o rivitalizzati con sempre maggior frequenza. Evidentemente pongono questioni e interrogativi che ancora ci scuotono, stimolano la creatività di artisti e reazioni anche contrastanti del pubblico. A partire da esempi attuali l'autrice costruisce un percorso a ritroso, diretto al lettore di oggi e finalizzato a una comprensione del presente. L'intento è mostrare come il “classico” possa assumere forme nuove, inedite e sorprendenti, proprio per la sua capacità di contaminarsi, mescolarsi, adattarsi e trasformarsi, interagire con i più diversi contesti.

Structure and Intrinsic Disorder in Enzymology offers a direct, yet comprehensive presentation of the fundamental concepts, characteristics and functions of intrinsically disordered enzymes, along with valuable notes and technical insights powering new research in this emerging field. Here, more than twenty international experts examine protein flexibility and cryo-enzymology, hierarchies of intrinsic disorder, methods for measurement of disorder in proteins, bioinformatics tools for predictions of structure, disorder and function, protein promiscuity, protein moonlighting, globular enzymes, intrinsic disorder and allosteric regulation, protein crowding, intrinsic disorder in post-translational, and much more. Chapters also review methods for study, as well as evolving technology to support new research across academic, industrial and pharmaceutical labs. - Unifies the roles of intrinsic disorder and structure in the functioning of enzymes and proteins - Examines a range of enzyme and protein characteristics, their relationship to intrinsic disorder, and methods for study - Features chapter contributions from international leaders in the field

Artificial Intelligence and Data Driven Optimization of Internal Combustion Engines summarizes recent developments in Artificial Intelligence (AI)/Machine Learning (ML) and data driven optimization and calibration techniques for internal combustion engines. The book covers AI/ML and data driven methods to optimize fuel formulations and engine combustion systems, predict cycle to cycle variations, and optimize after-treatment systems and experimental engine calibration. It contains all the details of the latest optimization techniques along with their application to ICE, making it ideal for automotive engineers, mechanical engineers, OEMs and R&D centers involved in engine design. - Provides AI/ML and data driven optimization techniques in combination with Computational Fluid Dynamics (CFD) to optimize engine combustion systems - Features a comprehensive overview of how AI/ML techniques are used in conjunction with simulations and experiments - Discusses data driven optimization techniques for fuel formulations and vehicle control calibration

Substance misuse and addictions are a public health issue. They affect the well-being of each community and nation as a whole. It is, therefore, necessary to identify, educate, and treat individuals who are addicted to substances. Policies and procedures go hand-in-hand with public health education and safety. The science behind the public health issues of one drug may be applicable to other drugs as well. However, marshalling all of the aforementioned information into a single source is somewhat difficult due to the wide array of material. The Editors address this by compiling the research in this single reference work that serves as a'one-stop-shopping'approach to everything readers need to know about the scientific basis of public health and addictions and agents of misuse.Apart from active agents that have a plant or chemical basis, there is a need to consider that there are other forms of addiction which may havecommon modes of causality or prevention. These include food addiction, gaming, gambling, and other non-drug addictions. These types of addiction may be related to the addiction of drugs.The Handbook of Substance Misuse and Addictions: From Biology to Public Health offers a holistic understanding of the relationship between public health and substance misuse. The text provides a common platform upon which other forms of addiction or substance misuse can be understood and treated. Addiction processes involve understanding the biological processes as well as behavior, psychology, sociology, and public health, all of which are interlinked. This Handbook is a useful reference for lecturers, students, researchers, practitioners, and other professionals in public health, addiction science, epidemiology, health education, health promotion, and health sciences.

Upon the arrival of the Greek'colonisers'in Sicily, in the 8th century BC, in addition to the Sicels or Sikeloi of the eastern area and the Sicani or Sicanians of the centre-west, according to historical sources there was a third local population residing in the extreme north-western tip of the island, that of the Elymians or Elymoi, with Segesta and Erice as their major cities. On their origin (whether they came from Italy or, rather, from Anatolia) the traditions are irreconcilable. Their language, documented by a series of very short and mostly fragmentary inscriptions on ceramics and by a few coin inscriptions, has been the subject of intense debate since at least the late decades of the 19th century. This essay (Elymian Inscriptions) dates back to 1977 and has served as a reference text ever since. After over forty years, in this Appendix the author presents updates to the volume's various sections: from those dedicated to epigraphic materials, to the various chapters focusing on the composition of the corpus, on handwriting, on text analysis, and on language reconstruction.

This encyclopedia contains 22 volumes and a total of 552 chapters covering up-to-date research in the field of public health.