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Revised by a collaborative, international, interdisciplinary team of editors and authors, this edition of the Manual of Clinical Microbiology includes the latest applications of genomics and proteomics and is filled with current findings regarding infectious agents, leading-edge diagnostic methods, laboratory practices, and safety guidelines. This edition also features four new chapters: Diagnostic Stewardship in Clinical Microbiology; Salmonella; Escherichia and Shigella; and Morganellaceae, Erwiniaceae, Hafniaceae, and Selected Enterobacterales. This seminal reference of microbiology continues to set the standard for state-of-the-science laboratory practice as the most authoritative reference in the field of microbiology. If you are looking for online access to the latest from this reference or site access for your lab, please visit www.wiley.com/learn/clinmicronow.

This is a timely and essential companion to the recently published Antimicrobial Resistance in the 21st Century, Second Edition. Antimicrobial resistance is a major threat to global population health, with government reports projecting it could result in over 10 million deaths in the next 35 years. Development of new agents to combat this threat is one of the WHO's top priorities, but in 2017, it conceded that the current drug development pipeline was insufficient to mitigate the threat. This book discusses recent progress and bolster new agent discovery and development, by providing researchers and students who will soon enter the field with a thorough guide to the advancements made in the last decade. Coverage includes new systemic antimicrobials approved since 2010, with detailed analysis of antibiotics, antivirals, antifungals, and antiparasitics, as well as agents in development for future use. Discussion of each drug will include its chemical nature, pharmacology/pharmacokinetics, antimicrobial spectrum, dosage, adverse reactions, drug interactions, microbial resistance, indications, clinical efficacy compared to older agents, and lists of similar agents with cost comparison. This volume is designed for researchers and students of infectious disease and medical microbiology, as well as clinicians in need of a comprehensive guide to newly developed agents.

This book is an evidence-based guide for some of the most common consult questions asked of a first-year infectious diseases (ID) fellow working in an academic teaching hospital. Divided into sections based on pathogen and organ system, each covered topic includes reviews of the latest published literature in succinct subsections that can be easily referenced. The book can be read cover to cover as an introduction to clinical infectious diseases through the eyes of an ID fellow or used as a reference in real-time when on clinical service. Written throughout the fellowship of an ID fellow, this handbook shares the quintessential ID topics most commonly encountered on the consult service. From global pandemics to the emergence of drug-resistant superbugs, interest in infectious diseases has never been higher. ID experts weigh in daily on a variety of cases ranging from simple urinary tract infections to devastating sepsis in patients with recent organ transplantation. The ID consult service can be overwhelming given the breadth of infectious diseases that affect our patients. This handbook offers an introductory yet comprehensive resource to professionals, practitioners, students, and fellows.

Viral Infections and Antiviral Therapies provides comprehensive coverage of viral infections and their transmission. Coverage includes antiviral agents, therapeutics, their mechanisms and treatment strategies. The book is organized into four sections, including an introduction to antiviral therapies, viral infections and their transmission, antiviral agents and therapeutics, and a market overview and future developments. The chapters in each section of the book discuss various key topics that are contributed to by an international group of leading experts. - Covers emerging and sexually transmitted viruses, including mode of transmission and pathophysiology of viral infections - Describes antiviral agents and therapeutics for viruses such as rotaviruses, enteroviruses and coronaviruses - Discusses strategies for the delivery of antiviral agents and vaccinations

This book is dedicated to questions of production planning and scheduling activities both in general and in semiconductor manufacturing environments, which have the characteristics of high volume and high mixture. It explores topics such as shop models, work-in-process management, the treatment of setup times, basic techniques of lot batching and splitting, lot sizing and group technology approaches, as well as rescheduling questions. A number of directions for further research is suggested in the book, and a broad collection of references is provided.

Why has China's authoritarian government under Xi Jinping retained popular support without political reforms? Drawing on Chinese social media data, in this book Titus C. Chen argues that China's digital propaganda and information control techniques--the monopolistic exercise of market authoritarianism--have empowered the Xi administration to manipulate public discourse and shape public opinion via social media. Chen argues that these techniques forge a sense of community and unite the general public under the Chinese government, thereby legitimating autocratic rule. By enhancing our understanding of China's digital ideological statecraft, the book makes a major contribution to the fields of China Studies and Political Communication.

Frontiers in Clinical Drug Research – HIV is a book series that brings updated reviews to readers interested in learning about advances in the development of pharmaceutical agents for the treatment of acquired immune deficiency syndrome (AIDS) and other disorders associated with human immunodeficiency virus (HIV) infection. The scope of the book series covers a range of topics including the medicinal chemistry and pharmacology of natural and synthetic drugs employed in the treatment of AIDS (including HAART) and resulting complications, and the virology and immunological study of HIV and related viruses. Frontiers in Clinical Drug Research – HIV is a valuable resource for pharmaceutical scientists, clinicians and postgraduate students seeking updated and critically important information for developing clinical trials and devising research plans in HIV/AIDS research.The fifth volume of this series features 5 chapters that cover these topics:- Clinical Eradication of Latent HIV Reservoirs: Where Are We Now?- HIV-1 Genotypic Drug Resistance Testing and Next-Generation Sequencing- Current and Promising Multiclass Drug Regimens and Long-Acting Formulation Drugs in HIV Therapy- Role of Nanotechnology in HIV Diagnosis and Prognosis- Preventive and Therapeutic Features of Combination Therapy for HIV

This textbook provides a structured, informed approach to the understanding and appreciation of drug action and effect providing a detailed description and discussion of pharmacokinetics and pharmacodynamics for nurses.The text focuses and emphasizes safe prescribing and administration of medication highlighting the possible harm to patient in terms of adverse reactions.This book also includes the seldom addressed facet of pharmacotherapeutics; drug formulation as applied to practice, and adverse reactions. It informs on the medication used to manage diabetes mellitus, respiratory disease, gastrointestinal tract, the central nervous system and many other affections.Uniting these essential pharmacological processes and applying them to physiological system based medications, this work highlights issues relevant to drug interaction and important nursing responsibilities associated with administration/prescribing. The overall aim of the text is to equip the nurse with an understanding of issues related to pharmacotherapeutics that is aligned to current nursing roles and statutory requirements.

This text comprehensively reviews the current state of the art in Laryngopharyngeal Reflux (LPR) together with a comprehensive explanation and description of the known gastroesophageal reflux (GERD) literature. With chapters written by experts from around the world, this text aims to deliver what is current in reflux recognition, diagnosis, reflux related complications, and the various treatment modalities. This is the first textbook to combine the most up to date knowledge of both LPR and GERD meant for both specialties and the general medicine population. Completely unique to the reflux literature is a section detailing the substantial benefits of a mostly plant based, Mediterranean style diet in the treatment of reflux disease. Encouraging patients to read and learn about diet and health is likely the most important step in improving their disease. The text provides direction to the caregiver on how to transition to a mostly plant-based diet. Review of myths, effects ofdiet in the setting of other disease states, and dietary consequences are explained. Guidelines on how to transition diet, dining out while maintaining a plant-based diet, and how to wean off medication, such as PPI, are also provided.Laryngopharyngeal and Gastroesophageal Reflux: A Comprehensive Guide to Diagnosis Treatment, and Diet-Based Approaches will provide the medical community with a resource to understand, teach, and provide the latest in LPR and GERD information to the caregiver and subsequently the patient.

Encyclopedia of Microbiology, Fourth Edition, Five Volume Set gathers both basic and applied dimensions in this dynamic field that includes virtually all environments on Earth. This range attracts a growing number of cross-disciplinary studies, which the encyclopedia makes available to readers from diverse educational backgrounds. The new edition builds on the solid foundation established in earlier versions, adding new material that reflects recent advances in the field. New focus areas include `Animal and Plant Microbiomes'and'Global Impact of Microbes`. The thematic organization of the work allows users to focus on specific areas, e.g., for didactical purposes, while also browsing for topics in different areas. - Offers an up-to-date and authoritative resource that covers the entire field of microbiology, from basic principles, to applied technologies - Provides an organic overview that is useful to academic teachers and scientists from different backgrounds - Includes chapters that are enriched with figures and graphs, and that can be easily consulted in isolation to find fundamental definitions and concepts

This book constitutes the proceedings of the 25th International Conference on Principles and Practice of Constraint Programming, CP 2019, held in Stamford, CT, USA, France, in September/October 2019.The 44 full papers presented in this volume were carefully reviewed and selected from 118 submissions. They deal with all aspects of computing with constraints including theory, algorithms, environments, languages, models, systems, and applications such as decision making, resource allocation, scheduling, configuration, and planning. The papers were organized according to the following topics/tracks: technical track; application track; multi-agent and parallel CP track; testing and verification track; CP and data science track; computational sustainability; and CP and life sciences track.

Globally, HIV-associated tuberculosis is one of the most important causes of infection-related death, accounting for one in every three HIV deaths and over 300,000 in 2017 alone. The HIV epidemic has undermined tuberculosis-control efforts in many countries around the world, as the virus has important modifying effects on the pathogenesis, diagnosis, and treatment of TB. The management of HIV-associated TB is also complicated by rapid clinical progression, immune reconstitution inflammatory syndrome, drug-drug interactions, and shared toxicities.The past two decades have yielded thousands of research publications and review articles on HIV-associated TB. HIV and Tuberculosis: A Formidable Alliance consolidates this massive amount of data into a single resource. With contributions from myriad disciplines, including epidemiology, immunology, public health, and clinical medicine, this book provides well-rounded and thorough coverage that will appeal to researchers and clinicians alike.

The 4th edition of Drug Interactions in Infectious Diseases is being split into two separate volumes – “Mechanisms and Models of Drug Interactions” and “Antimicrobial Drug Interactions”. This volume, “Antimicrobial Drug Interactions,” delivers a quick clinical resource that distills relevant drug interactions by antimicrobial drug class. The book provides informative tables on specific drug-drug interactions that include the degree and severity of the expected interaction. A mechanistic basis for drug-drug interactions is also provided to link observed interactions to pharmacologic characteristics of key drug classes. This complete resource is organized by major antibacterial, antimycobacterial, antiviral, antifungal, antimalarial, and antiprotozoal class. In line with current innovations in antimicrobial drug development, a distinct chapter on the pharmacologic management of drug interactions in hepatitis B virus (HBV) and hepatitis C virus (HCV)-relatedinfections is included. Two new chapters are dedicated to the management of human immunodeficiency virus (HIV) drug-drug interactions given the breadth of antiretroviral class-specific effects. This comprehensive review of known drug interactions and strategies to manage them is an invaluable resource to all health care practitioners.

The 4th edition of Drug Interactions in Infectious Diseases is being split into two separate volumes – “Mechanisms and Models of Drug Interactions” and “Antimicrobial Drug Interactions”. This volume, “Mechanisms and Models of Drug Interactions,” delivers a text that enhances clinical knowledge of the complex mechanisms, risks, and consequences of drug interactions associated with antimicrobials, infection, and inflammation. The book provides a comprehensive review of basic clinical pharmacology with a focus on metabolism and transporter-mediated drug interactions. The chapters address materials that cannot be retrieved easily in the medical literature, including materials focused on the complex interrelationship of acute infection, inflammation, and the risk of drug interactions in the Drug-Cytokine chapter. The Food-Drug and Herb-Drug interactions chapters remain definitive resources. A new chapter on in vitro modeling of drug interactions isincluded along with updates on design and data analysis of clinical drug interaction studies. Authoritative discussion of models for regulatory decision-making on drug-drug interactions provides the necessary framework to aid antimicrobial drug development. This concise review of the mechanisms and models of drug interactions provides important insights to health care practitioners as well as scientists in drug development.

The essential reference of clinical virology Virology is one of the most dynamic and rapidly changing fields of clinical medicine. For example, sequencing techniques from human specimens have identified numerous new members of several virus families, including new polyomaviruses, orthomyxoviruses, and bunyaviruses. Clinical Virology, Fourth Edition, has been extensively revised and updated to incorporate the latest developments and relevant research. Chapters written by internationally recognized experts cover novel viruses, pathogenesis, epidemiology, diagnosis, treatment, and prevention, organized into two major sections: Section 1 provides information regarding broad topics in virology, including immune responses, vaccinology, laboratory diagnosis, principles of antiviral therapy, and detailed considerations of important organ system manifestations and syndromes caused by viral infections. Section 2 provides overviews of specific etiologic agents and discusses their biology, epidemiology, pathogenesis of disease causation, clinical manifestations, laboratory diagnosis, and management. Clinical Virology provides the critical information scientists and health care professionals require about all aspects of this rapidly evolving field.

The Comprehensive Textbook of AIDS Psychiatry: A Paradigm for Integrated Care is the first book to provide insight into the interface between the psychiatric, medical, and social dimensions of HIV and AIDS and the need for a compassionate, integrated approach to the HIV pandemic with an emphasis on humanizing and destigmatizing HIV. Drawing from the expertise of 135 contributors in clinical and evidence-based medicine, the book provides information on the prevalence, incidence, medical and psychiatric aspects of HIV, as well as on the prevention and care of persons with HIV/AIDS.

Antipsychotic Long-acting Injections (LAIs) were introduced in the 1960s to improve treatment adherence in schizophrenia. Subsequently, first-generation antipsychotic LAIs became widely used in many countries. Since the initial publication of Antipsychotic Long-acting Injections in 2010, new trial data have been published on long-acting injection (LAI) preparations of the drugs Risperidone, Paliperidone, and Olanzapine. Furthermore, a new LAI preparation of the drug Aripiprazole has recently been approved for clinical use in the United States and is likely to be approved in Europe soon. The second edition of this successful book has been fully updated to include this new data, with reference to both observational studies and randomized controlled trials, as well as other new developments in the clinical use of antipsychotic LAIs. New chapters have been added covering the comparison between oral and injectable antipsychotics, Olanzapine LAI, Aripiprazole LAI, and the practicalities of organizing a specialized clinic for long-acting injectable antipsychotics. Existing chapters have also been thoroughly updated to take into account the most recently published research. Antipsychotic Long-acting Injections, Second edition brings together clinical and research findings on LAIs in a comprehensive volume, with chapters written by international experts.

Presenting the latest molecular diagnostic techniques in one comprehensive volume The molecular diagnostics landscape has changed dramatically since the last edition of Molecular Microbiology: Diagnostic Principles and Practice in 2011. With the spread of molecular testing and the development of new technologies and their opportunities, laboratory professionals and physicians more than ever need a resource to help them navigate this rapidly evolving field. Editors David Persing and Fred Tenover have brought together a team of experienced researchers and diagnosticians to update this third edition comprehensively, to present the latest developments in molecular diagnostics in the support of clinical care and of basic and clinical research, including next-generation sequencing and whole-genome analysis. These updates are provided in an easy-to-read format and supported by a broad range of practical advice, such as determining the appropriate type and quantity of a specimen, releasing and concentrating the targets, and eliminating inhibitors. Molecular Microbiology: Diagnostic Principles and Practice Presents the latest basic scientific theory underlying molecular diagnostics Offers tested and proven applications of molecular diagnostics for the diagnosis of infectious diseases, including point-of-care testing Illustrates and summarizes key concepts and techniques with detailed figures and tables Discusses emerging technologies, including the use of molecular typing methods for real-time tracking of infectious outbreaks and antibiotic resistance Advises on the latest quality control and quality assurance measures Explores the increasing opportunities and capabilities of information technology Molecular Microbiology: Diagnostic Principles and Practice is a textbook for molecular diagnostics courses that can also be used by anyone involved with diagnostic test selection and interpretation. It is also a useful reference for laboratories and as a continuing education resource for physicians. If you are looking for online access to the latest clinical microbiology content, please visit www.wiley.com/learn/clinmicronow.

This book provides an overview of intelligent decision-making techniques and discusses their application in production and retail operations. Manufacturing and retail enterprises have stringent standards for using advanced and reliable techniques to improve decision-making processes, since these processes have significant effects on the performance of relevant operations and the entire supply chain. In recent years, researchers have been increasingly focusing attention on using intelligent techniques to solve various decision-making problems. The opening chapters provide an introduction to several commonly used intelligent techniques, such as genetic algorithm, harmony search, neural network and extreme learning machine. The book then explores the use of these techniques for handling various production and retail decision-making problems, such as production planning and scheduling, assembly line balancing, and sales forecasting.

Clinical Challenges in Therapeutic Drug Monitoring: Special Populations, Physiological Conditions and Pharmacogenomics focuses on critical issues in therapeutic drug monitoring including special requirements of therapeutic drug monitoring important to special populations (infants and children, pregnant women, elderly patients, and obese patients). The book also covers issues of free drug monitoring and common interferences in using immunoassays for therapeutic drug monitoring. This book is essential reading for any clinician, fellow, or trainee who wants to gain greater insight into the process of therapeutic drug monitoring for individual dosage adjustment and avoiding drug toxicity for certain drugs within a narrow therapeutic window. The book is written specifically for busy clinicians, fellows, and trainees who order therapeutic drug monitoring and need to get more familiar with testing methodologies, issues of interferences, and interpretation of results in certain patient populations. - Offers busy clinicians, pathologists, and trainees a concise resource on the key aspects and critical issues in therapeutic drug monitoring - Focuses on patient populations such as infants and children, pregnant women, elderly patients, and obese patients, who have special requirements in therapeutic drug monitoring - Explores special topics in therapeutic drug monitoring including free drug monitoring and common immunoassay interference - Explains how individual dosage adjustments can prevent drug toxicity for certain drugs within a narrow therapeutic window

This volume thoroughly covers HIV-1 antiretrovirals currently in clinical use, together with their advantages and limitations. HIV-1 inhibitor resistance is discussed in detail, and critical assessments as to what will be required of future antiretrovirals in order to halt viral replication, reduce viral resistance, and alter the state of viral latency are presented. Experts at the forefront of HIV-1 research provide overviews of approaches from the fields of virology, chemical biology and structural biology for obtaining small molecule inhibitors that target viral regulatory and structural components at multiple points in the viral lifecycle. The individual chapters will appeal to scientists and clinicians alike.

Improving the performance of existing technologies has always been a focal practice in the development of computational systems. However, as circuitry is becoming more complex, conventional techniques are becoming outdated and new research methodologies are being implemented by designers. Performance Optimization Techniques in Analog, Mix-Signal, and Radio-Frequency Circuit Design features recent advances in the engineering of integrated systems with prominence placed on methods for maximizing the functionality of these systems. This book emphasizes prospective trends in the field and is an essential reference source for researchers, practitioners, engineers, and technology designers interested in emerging research and techniques in the performance optimization of different circuit designs.

Frontiers in Clinical Drug Research – HIV is an eBook series that brings updated reviews to readers interested in learning about advances in the development of pharmaceutical agents for the treatment of acquired immune deficiency syndrome (AIDS) and other

Over the last several years the field of humanized mice has matured and developed into an essential component of translational research for HIV/AIDS. Humanized mice serve both as vehicles for discovery and as highly sophisticated platforms for biomedical research. In addition, humanized mice have demonstrated outstanding potential for the investigation of critical aspects of the infection and pathogenesis of the hepatitis and herpes viruses, as well as highly relevant microbial infections such as tuberculosis and malaria. Humanized Mice for HIV Research provides a comprehensive presentation of the history, evolution, applications, and current state of the art of this unique animal model. An expansion of twelve review articles that were published in Humanized Mice by Springer in 2008 (Eds: Nomura T, Watanabe T, Habu S), this book expertly captures the outstanding progress that has been made in the development, improvement, implementation, and validation of humanized mouse models. The first two parts of this book cover the basics of human-to-mouse xenotransplantation biology, and provide critical information about human immune cell development and function based on individual models created from different immunodeficient strains of mice. The third and fourth parts investigate HIV-1 biology, including different routes of transmission, prevention, treatment, pathogenesis, and the development of adaptive immunity in humanized mice. The fifth part shows the broad applicability of humanized mice for therapeutic development, from long-acting antiretroviral combinations to genetic manipulations with human cells and cell-based approaches. The sixth part includes liver tissue engineering and the expansion of humanized mice for many other human cell-tropic pathogens.

This authoritative volume provides a contemporary view on the latest research in molecules with optimal drug-like properties. It is a valuable source to access current best practices as well as new research techniques and strategies. Written by leading scientists in their fields, the text consists of fourteen chapters with an underlying theme of early collaborative opportunities between pharmaceutical and discovery sciences. The book explores the practical realities of performing physical pharmaceutical and biopharmaceutical research in the context of drug discovery with short timelines and low compound availability. Chapters cover strategies and tactics to enable discovery as well as predictive approaches to establish, understand and communicate risks in early development. It also examines the detection, characterization, and assessment of risks on the solid state properties of advanced discovery and early development candidates, highlighting the link between solid state propertiesand critical development parameters such as solubility and stability. Final chapters center on techniques to improve molecular solubilization and prevent precipitation, with particularly emphasis on linking physiochemical properties of molecules to formulation selection in preclinical and clinical settings.

The Side Effects of Drugs Annual was first published in 1977. It has been continually published since then as a yearly update to the voluminous encyclopedia Meyler's Side Effects of Drugs. Each new Annual continues to provide clinicians and medical investigators with a reliable and critical yearly survey of new data and trends in the area of adverse drug reactions and interactions. An international team of specialists has contributed to the informative Annual by critically interpreting it and by pointing to whatever is misleading. - Provides a critical yearly survey of new data and trends on the side effects of drugs - Authored and reviewed by pioneers throughout the world in the clinical and practice sciences - An essential clinical on side effects of drugs for practitioners and healthcare professionals

Cytochrome P450 (CYP) is a super family of phase I enzyme in the biotransformation of xenobiotics and medications. Most medications undergo deactivation by CYP, and then are eliminated through either bile or kidneys from the body. CYP isozymes play a crucial role in drug interactions that may result in enhanced toxicity, reduced efficacy or onset of adverse reactions. On the other hand, many agents affecting CYP expression and activity may alter metabolic rate of different medications co-administrated. Therefore, the molecular basis, regulation by inducers or inhibitors, and pharmacologic reaction of specific CYP isozymes are the key issues of biochemical mechanisms, pharmaceutical development and safe use of various medications. This book is to meet the needs from basic molecular biochemists, pharmacologists, pharmacists, medical students, clinical practitioners and scientists, as well as broad readers who wish to understand how an herbal extract, medication or natural supplement is metabolized or transformed in the liver or other sites for deactivation and elimination. Special focuses are paid to herbal extracts and medications in the treatment of neuro-psychiatric or cardiovascular disorders, diabetes and viral hepatitis. Detailed dissection of drug interactions in a particular field intends to provide rationales for useful guidance of safe drug use in daily practice. The contributing authors are basic scientists, pharmacists, pharmacologists and on-service physicians in cardiovascular, neuro-psychiatric, gastroenterologic and hepatologic fields from Europe (Germany, France, Portugal), Australia, the US and China. Thus, the book is the collection of master pieces by well-known experts from various regions of the world, and represents the current understanding of CYP enzyme reaction and a contemporary coverage of possible drug interactions in involved fields. The featured chapters are scientific elucidation of basic biochemistry, pharmacology and clinical investigations in the interest of drug metabolism, interaction and safe use guidance in the single focus of this microsomal enzyme with multi-facet metabolic function.

The Side Effects of Drugs Annual was first published in 1977. It has been continually published since then as a yearly update to the voluminous encyclopedia, Meyler's Side Effects of Drugs. Each new Annual continues to provide clinicians and medical investigators with a reliable and critical yearly survey of new data and trends in the area of adverse drug reactions and interactions. An international team of specialists has contributed to the informative Annual by critically interpreting it and by pointing to whatever is misleading. - Provides a critical yearly survey of new data and trends - Special reviews in this Annual include, among other topics, epidemiology of the use of ecstasy, paracetamol and the risk of asthma, combination vaccines/multiple immunizations, interactions of herbal medicines with warfarin, and tyrosine kinase inhibitors

Fashion Supply Chain Management Using Radio Frequency Identification (RFID) Technologies looks at the application of RFID technologies in such areas as order allocation, garment manufacturing, product tracking, distribution and retail. As supply chains in the textiles and fashion industry become ever more complex and global, and as the shift to mass customization puts more pressure on a rapid and flexible response to customer needs, monitoring and improving supply chain efficiency in the industry becomes crucial. Radio frequency identification (RFID) technologies offer a unique opportunity to achieve these goals. This book reviews the role of RFID technologies in the textiles and fashion supply chain to improve distribution, process management and product tracking, garment manufacturing, and assembly line operations. It also explores how RFID technologies can improve order allocation in the supply chain, and how these technologies can also be used for intelligent apparel product cross-selling. Its chapters also discuss measuring the impact of RFID technologies in improving the efficiency of the textile supply chain, and modeling the effectiveness of RFID technologies in improving sales performance in fashion retail outlets. Fashion Supply Chain Management Using Radio Frequency Identification (RFID) Technologies is a comprehensive resource for academic researchers, industry managers, and professionals within the fashion industry. - Looks at the application of RFID technologies in order allocation, garment manufacturing, product tracking, distribution, and retail - Reviews RFID technologies in the textiles and fashion supply chain for improving distribution, process management and product tracking, garment manufacturing, and assembly line operations - Focuses on measuring the impact of RFID technologies on efficiency, and modeling the effectiveness of RFID technologies in improving retail outlet sales

Maschinenbelegungsprobleme werden seit Jahrzehnten intensiv untersucht. Dabei wurde das Multiprocessor Scheduling-Problem mit reihenfolgeabhängigen Rüstzeiten trotz seiner großen Bedeutung für Wissenschaft und Praxis bisher weitgehend vernachlässigt. Jörg Heuer entwickelt für diese Problemstellung neue heuristische Lösungsverfahren, mit denen sich gegenüber den existierenden Heuristiken erhebliche Verbesserungen im Hinblick auf Lösungsqualität, Robustheit und erforderliche Rechenzeit erzielen lassen. Die Untersuchung der Verfahrenseigenschaften erfolgt anhand einer Vielzahl von Probleminstanzen mit unterschiedlichen Merkmalen, die mit Hilfe eines neu erstellten Problemgenerators erzeugt werden. Auch bei den Lower Bounds, die zur Beurteilung der Lösungsqualität erforderlich sind, werden wesentliche Fortschritte erzielt.

Die vertragsärztlichen Arzneiverordnungen für ambulante Patienten werden seit 1985 im Arzneiverordnungs-Report analysiert. Datenbasis für 2012 sind 716 Millionen GKV-Rezepte (davon 634 Mio. Fertigarzneimittelrezepte), die von 203 599 Vertragsärzten ausgestellt wurden, darunter erstmals auch 60 533 Zahnärzte. In 40 Indikationsgruppen werden aktuelle Versorgungstrends dargestellt. Zum ersten Mal ist auch ein Kapitel über Rezepturarzneimittel enthalten sowie ein zusätzliches Kapitel über zahnärztliche Verordnungen.Presseecho zum Arzneiverordnungs-Report 2012„Noch viel Luft bei Pharmapreisen ‒ Arzneimittelreport sieht Milliarden-Einsparpotential“ (Frankfurter Allgemeine Zeitung 28.09.2012)„Deutsche zahlen bei Pillen drauf ‒ Untersuchung lobt Reformen, aber warnt vor neuem Ausgabenanstieg“ (Hannoversche Allgemeine Zeitung 28.09.2012)„Die Patienten zahlen drauf ‒ Die Kosten für Arzneimittel gehen wieder nach oben. Das ist ganz im Sinne der Industrie,doch schlecht für die Beitragszahler“ (Sächsische Zeitung 28.09.2012)„Pillenknick ‒ Der Preistopp wirkt: Kosten für Medikamente sinken, obwohl mehr verschrieben werden“ (Süddeutsche Zeitung 28.09.2012)

Solving scheduling problems has long presented a challenge for computer scientists and operations researchers. The field continues to expand as researchers and practitioners examine ever more challenging problems and develop automated methods capable of solving them. This book provides 11 case studies in automated scheduling, submitted by leading researchers from across the world. Each case study examines a challenging real-world problem by analysing the problem in detail before investigating how the problem may be solved using state of the art techniques.The areas covered include aircraft scheduling, microprocessor instruction scheduling, sports fixture scheduling, exam scheduling, personnel scheduling and production scheduling. Problem solving methodologies covered include exact as well as (meta)heuristic approaches, such as local search techniques, linear programming, genetic algorithms and ant colony optimisation.The field of automated scheduling has the potential to impact many aspects of our lives and work; this book highlights contributions to the field by world class researchers.

Le premier cas de SIDA a été observé aux USA en 1981 et le virus VIH-1 isolé à l'Institut Pasteur de Paris en 1983. Il est rapidement apparu que le VIH-1 était pandémique et que l'épicentre était situé en Afrique centrale ; le passage d'un virus du chimpanzé à l'Homme au début du XXe siècle a constitué l'événement princeps de cette pandémie. Le VIH-1 présente une grande variabilité génomique et il a effectué une formidable diversification après son passage chez l'Homme, aboutissant ainsi à la définition de groupes, de sous-types et de formes recombinantes circulantes (CRFs pour « circulating recombinant forms »). La répartition de ces virus est différente d'un continent à l'autre. Pour résumer la situation, on peut dire qu'il existe plus de 50 VIH-1 différents et que ceci explique les très grandes difficultés de mise au point d'un vaccin. L'auteur de ce livre, François-Charles Javaugue, a eu le mérite, le courage et la ténacité de réaliser une cartographie mondiale des différents VIH-1 en retraçant l'histoire de leur mise en évidence, le tout à partir de plusieurs milliers de références bibliographiques issues de revues scientifiques spécialisées. Il s'agit d'un travail unique en langue Française qui, à un moment donné, c'est-à-dire fin 2010 début 2011 et début 2012, présente l'ensemble des données publiées et est une référence, sinon la référence, dans le domaine.

Annual Reports in Medicinal Chemistry provides timely and critical reviews of important topics in medicinal chemistry together with an emphasis on emerging topics in the biological sciences, which are expected to provide the basis for entirely new future therapies. - Timely and critical reviews of important topics in medicinal chemistry

Genetic algorithms (GA) have become popular tools for search, optimization, machine learning, and solving design problems. These algorithms use simulated evolution to search for solutions to complex problems. A GA is a population-based computational method in which the population, using randomized processes of selection, crossover, and mutation, evolves towards better solutions. In this book, the authors present current research including the application of genetic algorithm optimization techniques in beam steering of circular array antenna; hybrid genetic algorithms; changing range genetic algorithms; study of the influence of forest canopies on the accuracy of GPS measurements using genetic algorithms; roundness evaluation by genetic algorithm; and optimal sizing of analog integrated circuits by applying genetic algorithms.

'I am unaware of any textbook which provides such comprehensive coverage of the field and doubt that this work will be surpassed in the foreseeable future, if ever!'From the foreword by Robert C. Moellering, Jr., M.D, Shields Warren-Mallinckrodt Professor of Medical Research, Harvard Medical School, USA Kucers'The Use of Antibiotics is the leading major reference work in this vast andrapidly developing field. More than doubled in length compared to the fifth edition, thesixth edition comprises 3000 pages over 2-volumes in order to cover all new and existing therapies, and emerging drugs not yet fully licensed. Concentrating on the treatment of infectious diseases, the content is divided into 4 sections: antibiotics, anti-fungal drugs, anti-parasitic drugs and anti-viral drugs, and is highly structured for ease of reference.Within each section, each chapter is structured to cover susceptibility, formulations and dosing (adult and paediatric), pharmacokinetics and pharmacodynamics, toxicity and drug distribution, detailed discussion regarding clinical uses, a feature unique to this title.Compiled by an expanded team of internationally renowned and respected editors, witha vast number of contributors spanning Europe, Africa, Asia, Australia, South America,the US and Canada, the sixth edition adopts a truly global approach. It will remaininvaluable for anyone using antimicrobial agents in their clinical practice and provides in a systematic and concise manner all the information required when treating infectionsrequiring antimicrobial therapy.Kucers'The Use of Antibiotics is available free to purchasers of the books as an electronic version on line or on your desktop: It provides access to the entire 2-volume print material It is fully searchable, so you can find the relevant information you need quickly Live references are linked to PubMed referring you to the latest journal material Customise the contents - you can highlight sections and make notes Comments can be shared with colleagues/tutors for discussion, teaching and learning The text can also be reflowed for ease of reading Text and illustrations copied will be automatically referenced to Kucers'The Use of Antibiotics

This book focuses on new small molecule approaches to combat viral infections. The chapters describe the discovery and development from bench through the clinic of relatively recently-approved antiviral drugs and compounds in advanced clinical development. Organized by a virus (such as HIV, HCV, RSV, influenza, HBV and CMV) and written by top academic and industrial authorities in the field, the book provides a unique opportunity to study, understand and apply discovery and development principles and learning without the need for an individual to research, analyze and synthesize all immense sourcing references. Topics showcase challenges and solutions of issues encountered, offering tremendous experience accumulated over many years of research that will be particularly useful to basic and bench scientists as well as clinicians as they continue discovering and developing new drugs and therapies.

'I am unaware of any textbook which provides such comprehensive coverage of the field and doubt that this work will be surpassed in the foreseeable future, if ever!'From the foreword by Robert C. Moellering, Jr., M.D, Shields Warren-Mallinckrodt Professor of Medical Research, Harvard Medical School, USA Kucers'The Use of Antibiotics is the leading major reference work in this vast andrapidly developing field. More than doubled in length compared to the fifth edition, thesixth edition comprises 3000 pages over 2-volumes in order to cover all new and existing therapies, and emerging drugs not yet fully licensed. Concentrating on the treatment of infectious diseases, the content is divided into 4 sections: antibiotics, anti-fungal drugs, anti-parasitic drugs and anti-viral drugs, and is highly structured for ease of reference.Within each section, each chapter is structured to cover susceptibility, formulations and dosing (adult and paediatric), pharmacokinetics and pharmacodynamics, toxicity and drug distribution, detailed discussion regarding clinical uses, a feature unique to this title.Compiled by an expanded team of internationally renowned and respected editors, witha vast number of contributors spanning Europe, Africa, Asia, Australia, South America,the US and Canada, the sixth edition adopts a truly global approach. It will remaininvaluable for anyone using antimicrobial agents in their clinical practice and provides in a systematic and concise manner all the information required when treating infectionsrequiring antimicrobial therapy.Kucers'The Use of Antibiotics is available free to purchasers of the books as an electronic version on line or on your desktop: It provides access to the entire 2-volume print material It is fully searchable, so you can find the relevant information you need quickly Live references are linked to PubMed referring you to the latest journal material Customise the contents - you can highlight sections and make notes Comments can be shared with colleagues/tutors for discussion, teaching and learning The text can also be reflowed for ease of reading Text and illustrations copied will be automatically referenced to Kucers'The Use of Antibiotics

'This book presents the most recent and established developments of Particle swarm optimization (PSO) within a unified framework by noted researchers in the field'--Provided by publisher.

The series of biannual international conferences “ANTS – International C- ference on Ant Colony Optimization and Swarm Intelligence”, now in its sixth edition, was started ten years ago, with the organization of ANTS'98. As some readers might recall, the?rst edition of ANTS was titled “ANTS'98 – From Ant Colonies to Arti?cial Ants: First International Workshop on Ant Colony Op- mization. ” In fact, at that time the focus was mainly on ant colony optimization (ACO), the?rst swarm intelligence algorithm to go beyond a pure scienti?c interest and to enter the realm of real-world applications. Interestingly, in the ten years after the?rst edition there has been a gr- ing interest not only for ACO, but for a number of other studies that belong more generally to the area of swarmintelligence. The rapid growth of the swarm intelligence?eld is attested by a number of indicators. First, the number of s- missions and participants to the ANTS conferences has steadily increased over the years. Second, a number of international conferences in computational - telligence and related disciplines organize workshops on subjects such as swarm intelligence, ant algorithms, ant colony optimization, and particle swarm op- mization. Third, IEEE startedorganizing,in 2003,the IEEE SwarmIntelligence Symposium (in order to maintain unity in this growing?eld, we are currently establishingacooperationagreementbetweenIEEE SISandANTSsoastohave 1 IEEE SIS in odd years and ANTS in even years). Last, the Swarm Intelligence journal was born.

“Intelligent systems are those which produce intelligent o?springs.” AI researchers have been focusing on developing and employing strong methods that are capable of solving complex real-life problems. The 18th International Conference on Industrial & Engineering Applications of Arti?cial Intelligence & Expert Systems (IEA/AIE 2005) held in Bari, Italy presented such work performed by many scientists worldwide. The Program Committee selected long papers from contributions presenting more complete work and posters from those reporting ongoing research. The Committee enforced the rule that only original and unpublished work could be considered for inclusion in these proceedings. The Program Committee selected 116 contributions from the 271 subm- ted papers which cover the following topics: arti?cial systems, search engines, intelligent interfaces, knowledge discovery, knowledge-based technologies, na- ral language processing, machine learning applications, reasoning technologies, uncertainty management, applied data mining, and technologies for knowledge management. The contributions oriented to the technological aspects of AI and the quality of the papers are witness to a research activity clearly aimed at consolidating the theoretical results that have already been achieved. The c- ference program also included two invited lectures, by Katharina Morik and Roberto Pieraccini. Manypeoplecontributedindi?erentwaystothesuccessoftheconferenceand to this volume. The authors who continue to show their enthusiastic interest in applied intelligence research are a very important part of our success. We highly appreciate the contribution of the members of the Program Committee, as well as others who reviewed all the submitted papers with e?ciency and dedication.

An overview of the rapidly growing field of ant colony optimization that describes theoretical findings, the major algorithms, and current applications.The complex social behaviors of ants have been much studied by science, and computer scientists are now finding that these behavior patterns can provide models for solving difficult combinatorial optimization problems. The attempt to develop algorithms inspired by one aspect of ant behavior, the ability to find what computer scientists would call shortest paths, has become the field of ant colony optimization (ACO), the most successful and widely recognized algorithmic technique based on ant behavior. This book presents an overview of this rapidly growing field, from its theoretical inception to practical applications, including descriptions of many available ACO algorithms and their uses.The book first describes the translation of observed ant behavior into working optimization algorithms. The ant colony metaheuristic is then introduced and viewed in the general context of combinatorial optimization. This is followed by a detailed description and guide to all major ACO algorithms and a report on current theoretical findings. The book surveys ACO applications now in use, including routing, assignment, scheduling, subset, machine learning, and bioinformatics problems. AntNet, an ACO algorithm designed for the network routing problem, is described in detail. The authors conclude by summarizing the progress in the field and outlining future research directions. Each chapter ends with bibliographic material, bullet points setting out important ideas covered in the chapter, and exercises. Ant Colony Optimization will be of interest to academic and industry researchers, graduate students, and practitioners who wish to learn how to implement ACO algorithms.