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Falciparum Malaria: Diagnostic Tools, Therapeutic Advances, and Future Opportunities discusses the current state of therapeutic options for malaria, antimalarial drugs and drug targets. The book also covers recent progress in the development of vaccines and other approaches for malaria treatment, prevention and control and explores diagnostic tools and biomarkers. Sections examine potential biomarkers and their applications, molecular diagnostic tools, multi-omic approaches for the characterization of therapeutic action of potential new antimalarials, therapeutic advances in falciparum malaria, antimalarial drugs, targeting parasite apicoplast for antimalarial drug discovery, cellular and adjunctive therapies for malaria treatment, and future opportunities. With contributions from experts in the field, this book is an ideal resource for academics, researchers, graduates and industry engaged in malaria research, its diagnosis, and treatment. - Reviews current therapeutic strategies of falciparum malaria - Covers antimalarial drugs, peptides, vaccines and RNAi approaches against malaria - Explores antimalarial drug targets in parasites - Discusses biomarkers and new diagnostic tools

Approx.590 pagesApprox.590 pages

This book will serve as a complete reference guide for the totality of salivary gland (SG) disease. Focusing on the clues available to the practitioner during the patient examination, it will completely review and update the available data concerning all manner of SG conditions. Looking beyond the perspectives of surgery, imaging, pathology, or sialendoscopy in diagnosis and therapy, this book will provide all professionals interested in the head and neck extensive and detailed diagnostic information about each SG entity. Achieving an accurate diagnosis involves the use of multiple clinical tools (history, physical examination, imaging, serology, biopsy etc). The indication for and significance of each of these investigative procedures will be discussed, integrated and photographically illustrated in tandem with the diagnostic review of the relevant SG entity. Besides a diagnostic review of readily diagnosed SG entities (Sjogren's, sialolithiasis, infection etc), the book willcover subjects whose diagnoses have been inadequately described (juvenile recurrent parotitis, sarcoid, radioactive iodine for thyroid cancer, pediatric Sjogren's, etc) or never reviewed (middle ear surgery and saliva, Stensen's duct dilatation, first bite syndrome, HIV paraparotid fat, etc) in other published texts. It will be organized by diagnosis. Written by an expert in the field with over six decades of clinical experience, Clinical Management of Salivary Gland Disorders will call attention to the large number of presenting patients who can be categorized as'false-positives.'This includes a psychosomatic group with perceptual salivary complaints, patients with masseteric hypertrophy, paraglandular opacities misdiagnosed as sialoliths, dental caries thought to have a salivary origin and more. Finally, this book will offer thorough methodology for identifying and diagnosing these initially confusing problems. An exhaustive resource for the field of salivary gland complaints, this book will be useful to otolaryngologists, head/neck surgeons, plastic surgeons, oral medicine/oral pathology practitioners and residents, oral and maxillofacial surgeons, and dentists. Internists concerned with physical diagnosis of head/neck problems, neuroradiologists concerned with relating imaging results to a clinical salivary gland condition and nurse practitioners and dental hygienists will also find this book most helpful.

Peritoneal Tumor Microenvironment of Cancers on Cancer Hallmarks: Perspectives of Translational Medicine provides readers with cutting-edge knowledge on tumor microenvironment. By exploring multiple aspects on tumor microenvironment, it gives an integrative insight on cancer diseases ranging from diagnosis to prediction of prognosis and individualized treatment.The book discusses topics such as clinical significance of tumor microenvironment, tumorigenesis and cancer progression, histopathological features of cancer in peritoneum, immune cells in tumor, exosomal cell-to-cell interactions, and therapeutic approaches to target tumor microenvironment. Additionally, it discusses tumor evolution during chemotherapy and metastasis, and future perspectives on identification and validation of biomarkers using liquid biopsy.This book is a valuable resource for cancer researchers, oncologists, medical doctors, and several members of biomedical field who want to understand the complex microenvironment of peritoneal tumors. - Discusses how to apply tumor microenvironment knowledge to diagnosis, prediction of prognosis, and individualized treatment of cancer - Provides readers with up-to-date knowledge on translational medicine, focusing on bench-to-bedside approach for cancer treatment and diagnosis - Presents collaborative research works from the perspectives of medical doctors, cancer researchers, basic biological scientists, and bioinformaticians to provide integrative insights on tumor microenvironment

Immuno-oncology and immunotherapy, Part B, Volume 191 in the Methods in Cell Biology series, highlights new advances, with this volume presenting chapters on a variety of topics, including Multiparametric flow cytometry study of human MDSCs, In vitro screening methods of novel immune checkpoint inhibitors related to T cell infiltration and anti-PD-1 resistance, Machine learning approach to assess brain metastatic burden in preclinical models, Cytofluorometric analysis of the maturation and activation of bone marrow-derived dendritic cells to assess immunogenic cell death, 3D agar colony inhibition assays to functionally evaluate HER2-targeting antibodies against human cancer cells elicited by vaccination in mice, and much more.Additional sections cover Spatial immunophenotyping of FFPE tissues by imaging mass cytometry, Processing human colon cancer specimens for in vitro cytotoxicity assays, A xenograft model of metastatic colon cancer, A preclinical model of hepatic metastasis to instruct effective treatment modalities, Myeloid-derived suppressor cells: Identification and function, Measuring the impact of therapy-induced senescence on NK cell phenotypes in cancer, and Selective expansion of anti-tumor innate lymphocytes in long-term cultures after a single BCG pulse. - Provides the latest information on cancer research - Offers outstanding and original reviews on a range of cancer research topics - Serves as an indispensable reference for researchers and students alike - Presents the latest release in the Methods in Cell Biology series

Advances in Host Genetics and Microbiome in Colorectal Cancer-Related Phenotypes, Volume 112 in the Advances in Genetics series, highlights new advances in the field with this new volume presenting interesting chapters on topics such as What we need in colorectal cancer research, and why?, Host Genetics and Microbiota procedures in colorectal cancer research, Host Genetics-associated mechanisms in colorectal cancer, Microbiota-associated mechanisms in colorectal cancer, Inflammation regulation in colorectal cancer, Microbiota and detrimental protein metabolites in colorectal cancer, Microbiota and other detrimental metabolites in colorectal cancer, Microbiota and beneficial metabolites in colorectal cancer, and much more. - Provides the authority and expertise of leading contributors from an international board of authors - Presents the latest release in the Advances in Genetics series - Includes the latest information on new advancements in the study of genetics

The Rose-Mackay Textbook of Autoimmune Diseases, Seventh Edition is a comprehensive reference that emphasizes the'3 P's'of 21st Century medicine: precision, prediction, and prevention. Topics cover the modern systems approach to biology that involves large amounts of personalized, ongoing physiologic data ('omics') coupled with advanced methods of analysis, new tests of genetic engineering, such as CRISPR, auto inflammatory diseases, autoimmune responses to tumor immunotherapy, and information on normal immune response and disorders. Each of the major autoimmune disorders is discussed by researchers and clinical investigators experienced in dealing with patients. This new edition continues its success with 75% of the content revised, updated, or completely new. This edition is a valuable resource to clinicians involved in the diagnosis and treatment of autoimmune disease, as well as to scientists who want to follow developments in the field. - Provides new research on autoimmune diseases, their diagnosis, prevention, and therapy - Covers a complete range of all common, rare and new autoimmune diseases, including cancer and COVID - Extensively revised with 75% new material based on autoimmunity, developments in the different diagnosis and therapies for these autoimmune diseases, and a completely updated description of the different diseases - Supplemented with a website that hosts a Podcast per chapter

Personalized Epigenetics, Second Edition discusses the core translatability of epigenetics to health management of individuals who have unique variations in their epigenetic signatures that can guide both disorder and disease prevention and therapy. Fully updated and revised, this new edition details inter-individual variability in the major epigenetic process in humans consisting of DNA methylation, histone modifications, noncoding RNA, and the diagnostic, prognostic, and therapeutic potential of the field. It also reviews the impact of the environment on epigenetic variations among individuals and the role of pharmacology and drug development in personalized epigenetics. Most importantly, the text covers personalized epigenetics from a disease-oriented perspective, presenting chapters that provide advances in widespread disorders or diseases, including diabetes, cancer, autoimmune disorders, obesity, cardiovascular diseases, neurological disorders, and pain management. - Includes new chapters on topics such as the limitations of personalized epigenetic variation comparisons; personalized epigenetics technologies; epigenetics of personalized nanomedicine; personalized epigenetic management of diabetes; epigenetics and chemoresistance; and personalized epigenetics and neurological disorders - Covers key methodological processes that are important in personalized medicine - Offers disease research case studies to provide in-depth discussion of examples of recent epigenetic research on a disease area - Features topics such as forensic epigenetics, epigenetics of personalized toxicity, limitations of epigenetic variation comparisons, and nanomedicine and nutrigenomics as applied to personalized epigenetics

In the past years, COVID-19 caused millions of deaths and severely damaged not only public health, but also the global economy. New variants continue to threaten human health. Thus, natural compounds for retarding infection are in high demand. This book summarizes the emerging research with flavonoids, whose application holds great promise of antivirus, anti-inflammation, antioxidative stress, and immunomodulatory. Topics include the role of flavonoids in preventing an inflammatory storm and how flavonoids interact with critical protein targets that are involved in the infection stages of COVID-19.Key Features• Highlights anti-SARS-CoV-2 drug discovery on natural products and medicinal plants• Includes all major subclasses of flavonoids that promisingly combat COVID-19 • Proposes molecular mechanisms of flavonoids against protein targets of SARS-CoV-2• Contributions from an international team of leading researchers• Provides recommendations with respect to the future research

Schachner and Hansen's Pediatric Dermatology has been the gold-standard reference in pediatric dermatology for more than 33 years. The new edition is a comprehensive textbook covering all the skin conditions of children and adolescents in a two-volume masterwork that will meet the expectations of pediatric dermatologists, dermatologists, pediatricians and all who provide pediatric healthcare.

Informed by the Biopsychosocial Model, this Encyclopedia of Child and Adolescent Health examines multiple aspects of child and adolescent development and physical and mental health. According to the Biopsychosocial Model, health is determined by the reciprocal interactions between biological (e.g., genetics, physical development, family health history), psychological (e.g., mental health, identity developmental, attitudes), and social (e.g., family, peers, school, social supports) factors. This theory posits that each one of these factors alone is not sufficient to understand health; instead, it is important to understand how these interactive components ultimately influence health outcomes. In addition to the Biopsychosocial Model, this Encyclopedia of Child and Adolescent Health has a translational approach. Each section and all applicable entries include a discussion of prevention or intervention efforts that can inform health and health promotion, and prevent health risks. - Presents a comprehensive review of current child and adolescent research, along with critical insights into the future direction of the field, including translation and prevention - Includes concise, authoritative chapters that are expertly authored make this an easy-to-read, reliable reference resource - Provides a clear thematic structure that allows for easy exploration across the discipline's different sub-fields. - Helps readers find their topics of interest, all of which are contextualized and linked to relevant literature

Is it possible for individuals to tackle waste by recycling, reusing and reducing alone? This provocative book critically analyses the widespread assumption that individuals and households have created our global waste crisis. Sociologist and waste expert Myra J. Hird reveals neoliberal capitalism's fallacy of infinite growth as the real culprit, and demonstrates how industry and local governments work in tandem to deflect our attention away from the real causes of our global waste problem. Hird offers crucial insights into the relations between waste and wider societal issues including ongoing (settler) colonialism, poverty, racism and sexism, and showcases how sociology may provide solutions through a ‘pubic imagination'of waste.

Common Pediatric Diseases: An Updated Review informs the reader about common diseases in children that are encountered by pediatricians and family physicians. Each of the 14 chapters in the volume presents updated information for readers with the aim to give them a current perspective on the topic. This book is a handy and practical compendium for medical students and healthcare professionals involved in general practice and pediatric clinics.The text starts with a quick introduction to pediatric diseases, before progressing towards specific diseases in children. The list of topics in this book includes pediatric rheumatological diseases, common oral diseases, pediatric metabolic syndromes, pediatric epilepsy syndromes, pediatric demyelinating disorder, genetic epileptic encephalopathies (with an algorithmic diagnostic approach), Henoch-Sch amp;amp;ouml;nlein purpura, atopic dermatitis, childhood-onset systemic lupus erythematosus, Severe Combined Immunodeficiency, PFAPA, aphthous stomatitis, pharyngitis, cervical adenitis syndrome and pediatric hepatoblastoma.[Series Intro]Updates on Pediatric Health and Disease is a comprehensive series of books on infant and adolescent health and diseases. The series features volumes that update readers on current understanding in basic information and advanced clinical practice in pediatric medicine. Neonatology as well as different diseases in all subspecialties of pediatrics, including allergy and immunology, cardiology, endocrinology, gastroenterology, hematology, infectious diseases, nephrology, oncology, pulmonology, rheumatology, neurology, psychiatry and dermatology are represented in each volume.

Foundations of Colorectal Cancer provides a holistic and comprehensive dive into colorectal cancer, discussing the contributions of each discipline that studies it, allowing its understanding from the most demographic and ethical facts, to the treatment process, its varieties and genetic background. Written by experts in diverse areas such as cancer research, oncology, genetics, biochemistry, psychology, social sciences, bioinformatics and palliative care, the book brings real-world experiences to help readers with any challenge they may face when dealing with patients or during their research workflow.The content is split into nine sections: Clinical manifestations and disease detection, covering primary and secondary prevention, and the role of primary care; Diagnosis and staging, discussing endoscopy, colonoscopy, molecular pathology, and anatomopathological diagnosis; Treatment, including endoscopic, surgical, radiological, and postoperative approaches; Molecular and biological mechanisms, with the role of intestinal microbiota, stem cells and signaling pathways; New diagnostic methods, encompassing biomarkers and bioinformatics tools for research; Biobanks, with an overview of their regulations and importance in the research; Epidemiological studies, focusing on incidence and mortality globally and by regions; Hereditary colorectal cancer, differentiating nonpolyposis and polyposis types; and Addressing the consequences of colorectal cancer, covering psychological effects, nutrition and ethical issues. - Provides a multidisciplinary approach with a holistic view of colorectal cancer, ranging from basic science to population studies, with its social and environmental influences and impacts, interpreting the disease as a medical, chemical, physical, microbial, psychological, and social condition - Written by a diverse group of specialists with complementary expertise, including oncologists, radiologists, biochemists, surgeons, psychologists, social workers and clinicians, all members of the Galician Research Network of Colorectal Cancer (REGICC) with vast collaboration experience to bring comprehensive knowledge on the subject - Encompasses reliable information suitable for different workers within the healthcare sector and research community dedicated to colorectal cancer, from clinicians and healthcare providers, researchers on several aspects of cancer, to bioinformaticians who deal with health data - Includes many case studies throughout the chapters discussed by specialists with high scientific accuracy and didactic value, in order to clearly and precisely share their professional experience on the subject with readers

SCHALM'S VETERINARY HEMATOLOGY An updated guide to veterinary hematology with expanded coverage on a variety of topics The revised seventh edition of Schalm's Veterinary Hematology is updated to provide a comprehensive review of all topics related to disorders of the blood in animals. Designed as a gold-standard reference, this text covers a wide range of species in both confined and free-range populations, reflects the most recent trends in hematology diagnostics, and discusses recent advances in traditional techniques. Edited and written by an international team of experts in the field, the book represents an accessible yet in-depth resource for information on veterinary hematology. The new edition includes a hemolymphatic tissue section that covers current understanding of basic science and the species-specific hematology section is further expanded from previous editions. New chapters address emerging topics in hematology, and existing chapters have been revised and rearranged to improve readability and simplify access to the material. This seventh edition: Updates the most complete reference on veterinary hematology across species Contains a new section on basic biology of hemolymphatic tissues Expands coverage of species-specific hematology Presents new and emerging topics in blood disorders and diagnostic techniques Features a reorganized contents list for an integrated, easy to use reference Written for veterinary clinical pathologists and residents, diagnostic laboratory staff, internists, and specialists, Schalm's Veterinary Hematology is the most comprehensive and up-to-date reference on the topic.

Encyclopedia of Infection and Immunity, Four Volume Set provides new insights into the interactions between bacteria, fungi, parasites and their hosts. Specific areas of interest include host cellular and immune response to microbes, molecular mechanisms of action of beneficial microbes or host-associated microbial communities, microbial pathogenesis, virulence factors, experimental models of infection, host resistance or susceptibility, and the generation of innate and adaptive immune responses. Comprised of over 200 chapters written and edited by leading experts in the field, this book will serve as a key resource for students, researchers, academics and industry practitioners in the fields of microbiology, immunology, and infectious diseases. More than 100 years after Robert Koch and Louis Pasteur established the microbial etiology of communicable diseases, the field of microbiology is experiencing a second period of rapid growth and expansion, driven by the realization that changes in host-associated microbial communities might be at the root of a broad spectrum of noncommunicable human diseases. These advances follow on the heels of recent progress in high-throughput sequencing technology, which has provided a wealth of information on the human microbiome and its physiological potential. - 2023 PROSE Awards - Winner: Finalist: Reference Works – Biological and Life Sciences: Association of American Publishers - Offers a contemporary review of current infection and immunity research, and insights into the future direction of the field - Meticulously researched and cross-referenced to allow students, researchers and professionals to find relevant information quickly and easily - Includes chapters written by academics and practitioners from various fields and regions, ensuring that the knowledge within is easily understood by, and applicable to, a large audience

This book provides a comprehensive overview of the latest advances in a wide range of biomaterials for the development of smart and advanced functional materials. It discusses the fundamentals of bio-interfacial interactions and the surface engineering of emerging biomaterials like metals and alloys, polymers, ceramics, and composites/nanocomposites. In turn, the book addresses the latest techniques and approaches to engineering material surfaces/interfaces in, e.g., implants, tissue engineering, drug delivery, antifouling, and dentistry. Lastly, it summarizes various challenges in the design and development of novel biomaterials. Given its scope, it offers a valuable source of information for students, academics, physicians and particularly researchers from diverse disciplines such as material science and engineering, polymer engineering, biotechnology, bioengineering, chemistry, chemical engineering, nanotechnology, and biomedical engineering for various commercial and scientificapplications.

Recapitulating The Stem Cell Niche Ex Vivo, Volume Six in the Advances in Stem Cells and their Niches series, highlights new advances in the field, with this new volume presenting interesting chapters on a variety of topics, including Recapitulating the bone marrow stem cell niche ex vivo, The generation of the liver ex vivo, Recapitulating the thymic stem cell niche ex vivo, Recapitulating the intestinal epithelium stem cell niche ex vivo, Recapitulating the lung stem cell niche in vitro, Recapitulating mammary tissue in vitro, and Recapitulating muscle in vitro. - Provides the authority and expertise of leading contributors from an international board of authors - Presents the latest release in the Advances in Stem Cells and their Niches series - Includes the latest information on Recapitulating the stem cell niche ex vivo

The material of ITP became more and more complex and substantial in recent years. The current edition was updated in a difficult time reflected by the COVID-19 pandemic with many obstacles and adversities. Therefore all authors worked hard on this edition and contributed to the successful completion of this book. It would be a desirable conclusion if this new edition would contribute to optimal ITP patient care and management.

For decades, Emery and Rimoin's Principles and Practice of Medical Genetics and Genomics has served as the ultimate resource for clinicians integrating genetics into medical practice. With nearly 5,000 pages of detailed coverage, contributions from over 250 of the world's most trusted authorities in medical genetics, and a series of 11 volumes available for individual sale, the Seventh Edition of this classic reference includes the latest information on seminal topics such as prenatal diagnosis, genome and exome sequencing, public health genetics, genetic counseling, and management and treatment strategies to complete its coverage of this growing field for medical students, residents, physicians, and researchers involved in the care of patients with genetic conditions. This comprehensive yet practical resource emphasizes theory and research fundamentals related to applications of medical genetics across the full spectrum of inherited disorders and applications to medicine more broadly. In Metabolic Disorders, leading physicians and researchers thoroughly examine medical genetics as applied to a range of metabolic disorders, with emphasis on understanding the genetic mechanisms underlying these disorders, diagnostic approaches, and therapeutics that make use of current genomic technologies and translational studies. Here genetic researchers, students, and health professionals will find new and fully revised chapters on the genetic basis of body mass, amino acid, carbohydrate, iron, copper, lipo protein, and lipid metabolic disorders, as well as organic acidemias, fatty acid oxidation, and peroxisome disorders among others. With regular advances in genomic technologies propelling precision medicine into the clinic, Emery and Rimoin's Principles and Practice of Medical Genetics and Genomics: Seventh Edition bridges the gap between high-level molecular genetics and practical application and serves as an invaluable clinical tool for health professionals and researchers. - Wholly revised and up-to-date, this volume thoroughly addresses medical genetics and genomics as applied to metabolic disorders, with emphasis on understanding the genetic mechanisms underlying these disorders, diagnostic approaches, and treatment methods - Provides genetic researchers, students, and health professionals with up-to-date coverage on the genetic basis of a range of metabolic disorders, including body mass, amino acid, carbohydrate, iron, copper, lipo protein, and lipid metabolic disorders, as well as organic acidemias, fatty acid oxidation, and peroxisome disorders among others - Includes color images supporting identification, concept illustration, and method processing - Features contributions by leading international researchers and practitioners of medical genetics - A robust companion website offers lecture slides, image banks, and links to outside resources and articles to stay up-to-date on the latest developments in the field

Bone Cancer: Bone Sarcomas and Bone Metastases - From Bench to Bedside, Third Edition comprehensively investigates key discoveries in the field of bone biology. New aspects of bone cancer biology are treated in new chapters covering exosomes, autophagy, and metabolism. These have led to the development of entirely new areas for investigation, such as therapies which combine surgery and biological approaches. The Third Edition expands on the original overview of bone cancer development (physiology and pathophysiology), with 40% new material. Each chapter has been written by internationally recognized specialists on the bone cancer microenvironment, bone metastases, osteoclast biology in bone cancer, proteomics, bone niche, circulating tumor cells, and clinical trials. Given the global prevalence of breast and prostate cancers, knowledge of bone biology has become essential for everyone within the medical and cancer research communities. Bone Cancer: Bone Sarcomas and Bone Metastases - From Bench to Bedside continues to offer the only translational reference to cover all aspects of primary bone cancer and bone metastases. This revision opens the door to myeloma with two short chapters dedicated to this bone-associated disease. - Covers the broad field of bone sarcomas and bone metastases from basic research to clinical approaches - Presents comprehensive and translational overview of biological and clinical aspects of bone cancers, discussing pathophysiology from genetic and molecular levels using the most recent evidence - Provides a common language for cancer researchers, bone biologists, oncologists, and radiologists to discuss bone tumors and how bone cancer metastases affects each major organ system - Offers insights to research clinicians (oncologists and radiologists) into understanding the molecular basis of bone cancer, leading to more well-informed diagnoses and treatment of tumors and metastases - Offers insights to bone biologists into how clinical observations and practices can feed back into the research cycle and, therefore, can contribute to the development of more targeted genomic and proteomic assays

This book introduces the clinical analysis and accompany cases of paediatric Kawasaki disease. It has 14 chapters about typical Kawasaki disease, atypical Kawasaki disease, recurrent, misdiagnosis, and complications involved different systems, such as cardiovascular, digestive, nervous, blood, respiratory, urinary, bone and joints, and endocrine systems complications. In this book, 53 Kawasaki cases are presented with clinical history, physical examination, laboratory findings, diagnosis, treatment and discussion. This book is helpful for clinicians, ultrasonologist, and radiologist to support early diagnosis and proper treatment, which can significantly improve the prognosis of Kawasaki disease.

This contributed volume provides a complete overview of Neuro-Behçet's disease (NBD), one of the most serious manifestations of Behçet's disease. It serves as a comprehensive and critical review of the current scientific literature regarding NBD, covering the epidemiology, pathology, prognosis, and treatment of the disease. This book is an essential resource for both researchers and physicians working on neurology, rheumatology, and internal medicine fields.

Volume Immunodeficiency Diseases in Springer's gold-standard reference work on medical immunology focuses on infectious diseases. In tandem with its three counterpart volumes it offers the most wide-ranging and authoritative repository of knowledge on infectious diseases, with readily accessed contributions by the world's leading authorities on the subject. The encyclopedia covers the material from all angles, with more than 1000 pages of essays on the genetics, physiology, metabolism, pathogenesis and applied microbiology of all known infectious diseases, and includes access to an e-reference work that will include ongoing updates reflecting the latest advances in the field.An outstanding new resource of immense value to a wide range of medical researchers and practitioners, the encyclopedia features a user-friendly subdivision of diseases according to their affective locus in the human body. The sections cover integumentary, skeletal, respiratory, digestive, urinary, and reproductive transmissible pathogens. This high-profile encyclopedia will be an essential addition to academic libraries worldwide.

This book addresses the biological processes relevant to the immune phenotypes of cancer and their significance for immune responsiveness, based on the premise that malignant cells manipulate their surroundings through an evolutionary process that is controlled by interactions with innate immune sensors as well as the adaptive recognition of self/non-self. Checkpoint inhibitor therapy is now an accepted new form of cancer treatment. Other immuno-oncology approaches, such as adoptive cell therapy and metabolic inhibitors, have also shown promising results for specific indications. Immune resistance is common, however, limiting the efficacy of immunotherapy in many common cancer types. The reasons for such resistance are diverse and peculiar to the immune landscapes of individual cancers, and to the treatment modality used. Accordingly, approaches to circumvent resistance need to take into account context-specific genetic, biological and environmental factors that may affect the cancer immune cycle, and which can best be understood by studying the target tissue and correlated systemic immune markers. Understanding the major requirements for the evolutionary process governing human cancer growth in the immune-competent host will guide effective therapeutic choices that are tailored to the biology of individual cancers.

For nearly 50 years, Sleisenger & Fordtran's Gastrointestinal and Liver Disease has been the go-to reference for gastroenterology and hepatology residents, fellows, physicians, and the entire GI caregiving team. Now in a fully revised 11th Edition, this two-volume masterwork brings together the knowledge and expertise of hundreds of global experts who keep you up to date with the newest techniques, technologies, and treatments for every clinical challenge you face in gastroenterology and hepatology. A logical organization, more than 1,100 full-color illustrations, and easy-to-use algorithms ensure that you'll quickly and easily find the information you need. - Features new and expanded discussions of chronic hepatitis B and C, Helicobacter pylori infection, colorectal cancer prevention through screening and surveillance, biologic agents and novel small molecules to treat and prevent recurrences of inflammatory bowel disease (IBD), gastrointestinal immune and autoimmune diseases, and more. - Offers reliable coverage of key topics such as Barrett's esophagus, gut microbiome, enteric microbiota and probiotics, fecal microbiota transplantation, and hepatic, pancreatic, and small bowel transplantation. - Provides more quick-reference algorithms that summarize clinical decision making and practical approaches to patient management. - Employs a consistent, templated, format throughout for quick retrieval of information. - Includes monthly updates online, as well as more than 20 procedural videos. - Expert Consult™ eBook version included with purchase. This enhanced eBook experience allows you to search all of the text, figures, and references from the book on a variety of devices.

This book explains the immunology of organ-specific malignancies and discusses novel immunotherapy strategies for their treatment. Since the first, very successful edition of the book was published in 2015, a number of entirely new chapters have been included. The range of cancers considered has accordingly been extended, with coverage of the latest immunotherapy approaches for cancers in different organs. In addition, the original chapters have been updated to document the latest advances in immunotherapy for pediatric solid tumors, hematologic malignancies, gastrointestinal tumors, bone tumors, central nervous tumors, lung cancer, genitourinary tract tumors, and breast cancer, among others. The book is published as part of the three-volume Springer series Cancer Immunology, which aims to provide an up-to-date, clinically relevant review of cancer immunology and immunotherapy. Other volumes in the series address the translational medicine context and bench to bedside immunotherapy. Cancer Immunology: Cancer Immunotherapy for Organ-Specific Tumors will be of special value to clinical immunologists, hematologists, and oncologists.

La storia dello spettacolo in Italia è una materia piuttosto nuova, che si forma accademicamente nella temperie politica, culturale e artistica che si snoda fra gli anni Sessanta e gli Ottanta. Ma la sua vicenda è molto più lunga e complessa. Anzitutto, perché poggia su di una tensione storiografica preesistente: per questo, più che di “nascita”, nel nostro Paese si parla di rifondazione degli studi di teatro. E poi in quanto alcune delle domande alla base del nuovo paradigma scientifico – a partire dalla definizione stessa dell'oggetto d'indagine – continuano a riverberare anche in seguito. Incastonato com'è fra passato e futuro, il processo di istituzione della disciplina non rappresenta esclusivamente uno snodo-chiave nella nostra cultura teatrale novecentesca. È anche una tappa, certo dirompente, di una storia di più lunga durata, da un lato in larga misura già in atto rispetto al momento che si è soliti considerare il suo innesco e dall'altro lato per certi versi tuttora ben viva e attiva. Questo libro ha il proposito di ricostruire i primi passi di tale progetto, alla ricerca tanto delle ragioni che a un certo punto, intorno alla metà del XX secolo, hanno spinto una serie di giovani ricercatori a perimetrare il nuovo campo di studio; quanto degli esiti di quei percorsi, che hanno portato a immaginare – e poi a concretizzare – un altro, nuovo modo di pensare e studiare il teatro all'interno dell'università, che a tutt'oggi pone questioni ancora estremamente attuali.

This book comprises a collection of categorized case-based questions, directed and meticulously selected to cover the most common and most important aspects of immunodeficiency diseases. Immunodeficiency disorders of infancy and childhood such as antibody deficiencies, phagocyte defects and defects in innate immunity are addressed among others. Each chapters starts with a brief of the initial presentation and lab data of the patient, followed by a series of 5-6 multiple choice questions (MCQs), leading the reader to the diagnosis and best of practice in a step-wise manner. This MCQ format along with precise, yet detailed answer ensures a quick, case-based, reality learning to the reader. This comprehensive MCQ series, is an essential reading material that a pediatric clinician, hematologist, immunologist, transplant specialist, or pulmonologist, can not afford to miss.

Immunosenescence is an imprecise term used to describe deleterious age-associated changes to immune parameters observed in all mammals studied so far. It represents a rapidly progressing science in the aging field, with a vertiginous volume of new data, knowledge and concepts concerning these changes. We are poised to be in a position to translate these accumulated data into the clinical setting via better understanding of the contribution of immunosenescence to age-associated pathologies, and their prevention by appropriate interventions. This authoritative handbook seeks to encompass the current state of our knowledge on the multitude of those changes to immunity related to aging, with contributions from experts in the research and clinical areas. This book therefore considers methods and models for studying immunosenescence; cellular immunosenescence of T cells, B cells, neutrophils, antigen presenting cells, NK, NKT and stem cells; genetics; mechanisms including receptors and signal transduction; mitochondria; proteasome; cytokines; neuro-endocrine-immune networks; inflammation; thymus; clinical relevance in disease states including infections, autoimmunity, cancer, metabolic syndrome, neurodegenerative diseases, frailty and osteoporosis; modulation by nutrition, lipids, vaccination and the question “can interventions to influence immunosenescence be realistically proposed based on our current state of knowledge?”.

At the time of the first edition of Principles of Cancer Biotherapy in 1987, this book represented the first comprehensive textbook on biological therapy. In 1991, when the second edition was published, there was still some doubt on the part of many oncologists and cancer researchers as to the therapeutic value of these new approaches. By 2003 and the fourth edition, it was generally agreed that biopharmaceuticals were producing major opportunities for new cancer therapies. Cancer biotherapy has now truly matured into the fourth modality of cancer treatment. This fifth revised edition describes the tremendous progress that has been made in recent years using biologicals in cancer treatment. This book summarizes an evolving science and a rapidly changing medical practice in biotherapy. In this new millennium, it is now possible to envision a much more diversified system of cancer research and treatment that will afford greater opportunities for a patient's personalized cancer treatment. This was first envisioned in the 1987 initial edition of this textbook and is now a'new'and popular approach to cancer treatment. Some forms of cancer biotherapy use the strategy of tumor stabilization and control though continued biological therapy, akin to the use of insulin in the treatment of diabetes. This textbook illustrates new methods of thinking and new strategies for control of cancer. It is always difficult to move from past dogma to future opportunity, but this fifth edition of Principles of Cancer Biotherapy illustrates why it is so important to the patients for researchers and clinicians to explore and quickly apply these new opportunities in cancer biotherapy.

Explore what's new in the new edition!Trusted for four decades by university faculty and relied on by thousands of professionals from diverse fields, Children with Disabilities is the gold-standard text on working effectively with children and families. Now this authoritative resource is in its eighth edition, enhanced with new chapters on critical topics, the latest evidence-based practices, updated instructor materials, and guidance on working with a wide range of professionals to address every aspect of child health and well-being.Spearheaded by senior editor Mark Batshaw, M.D., Chief Academic Officer at Children's National Health System, this new edition is an unparalleled compendium of information about developmental, clinical, family, education, and intervention issues, from birth through adolescence. Every chapter has been meticulously peer-reviewed, and content has been updated throughout to reflect important new research and developments in diverse fields. Comprehensive coverage of contemporary issues makes this volume an indispensable reference for practicing professionals, and the student-friendly features and multimedia instructor materials make it the ultimate textbook for courses on disability.A treasury of essential knowledge from a who's who of today's leading experts and innovators, Children with Disabilities is a cornerstone resource that professionals will use year after year to support their important work and ensure that every child and family thrives.WHAT'S NEWExpanded focus on interdisciplinary care, including practical guidance on how professionals from different fields can effectively collaborateNew chapters on key topics: sleep disorders, assessment of physical disabilities, the senses, rehabilitative services, interdisciplinary care, the role of medication, and the effect of health care disparities on child outcomesNew Evidence-Based Practice boxes throughout the text, for easy review of recent studies and recommended practices Updated nomenclature based on new developments in the field and recommendations from respected organizationsSTUDENT-FRIENDLY FEATURES: Students will benefit from chapter overviews, a helpful glossary, case studies that bring key concepts to life, thought questions, a test bank with more than 200 questions for faculty members, resource lists for further reading, and 200+ downloadable illustrations. And with the complete package of multimedia instructor materials, instructors will use this textbook effectively in their courses and prepare students for years of successful practice.Explore what's new in the new edition!

This book presents detailed state of the art knowledge on the humoral primary immunodeficiencies (PIDs), i.e., disorders arising from impaired antibody production due to defects intrinsic to B cells or defective interaction between B and T cells. There is extensive coverage of both basic science discoveries and the latest clinical advances in the field. The book is structured in accordance with the most recent classification of PIDs and also covers updates on the B cell immunological synapse. Readers will find comprehensive, in-depth descriptions of novel humoral PID genes and related clinical applications, mucosal B cells, and the various clinical phenotypes of humoral PIDs. Aspects such as differential diagnosis, clinical management in children and adults, and the role of vaccines are also addressed. The authors are all recognized experts from Europe, Australia, and the United States. Humoral Primary Immunodeficiencies will be of high value for immunologists, pediatricians,rheumatologists, oncologists, internists, and infectious disease specialists and will also be informative for MD and PhD students.

In this compilation, the authors propose that strength training is a fundamental part of the aging process to maintain the functionality which is affected in the elderly stage of life. Mode circuit and strength training has been very useful as hey provide variability of movements and promote total body intervention. Next, the authors aim to deliver a descriptive, current-state view of the health situation in the Arab World, including the challenges facing public health within the region. They also provide decision-makers and health policy experts an evidence-based contextual analysis that is driven by needs assessments in the region. The following review focuses on the preclinical therapeutic efficacies of polymers carriers incorporated with antimalarials. These carriers have unique properties such as excellent biodegradability, good biocompatibility, reduced non-toxic effects of the loaded/encapsulated drug and improved drug pharmacokinetics. Incorporating antimalarials onto these carriers can improve their therapeutic outcomes. This collection goes on to review the symptoms, diagnostic approach and treatment options of agammaglobulinemia disorders. Patients with agammablobulinamia usually present with recurrent infections caused by encapsulated bacteria although viral, fungal and parasitic infections can also occur. Diagnosis is initially based upon family/clinical history and physical examination. Another review focuses on clinical studies showing the role that oral magnesium supplementation plays in the improvement of insulin sensitivity. A growing body of evidence from experimental studies shows that hypomagnesemia reduces the tyrosine-kinase activity and autophosphorylation at insulin receptor level, which promotes the aforementioned hypothesis. Pleural effusion occurs when fluid collects in the pleural space, between the parietal and visceral pleura. Many disease processes are associated with pleural effusion, which require physicians to be familiar with its causes, diagnosis, and management. The authors propose that pleural fluid procalcitonin has been shown to be a useful bio-marker for diagnosing a bacterial parapneumonic pleural effusion. Later, a patient with elevated CPK and evidence for prevention of exercise induced rhabdomyolysis is presented. Rhabdomyolysis may present as muscle aches that may not necessitate a visit to the physician, but in some cases it may be fatal. Thus, physicians must always inquire about participation in exercise and counsel athletes and trainers. In the concluding chapter, the authors showcase how to use stereo digital displays for the diagnosis and treatment of amblyopia. In recent years, stereo digital displays have been introduced to provide 3D illusions. Usually they are used for recreational purposes, but the underlying idea can be applied to the medical field.

Bollato spesso dalla nuova critica teatrale come passatista e nostalgico, «Il Dramma» (periodico fondato nel 1925 da Pitigrilli insieme a Lucio Ridenti, che ne fu il vero animatore e il direttore fino al 1973) e il suo archivio, prodotto in decenni di lavoro redazionale “sul campo”, costituiscono oggi una vera e propria riscoperta storica, offrendosi come uno strumento imprescindibile per chiunque voglia penetrare la cultura teatrale del nostro Paese. Esso risente fortemente della poliedrica personalità di Ridenti, già attore, fotografo, consigliere d'eleganza (e dandy egli stesso), giornalista, editorialista, intenditore d'arte.Il convegno di studi “Il laboratorio di Lucio Ridenti. Cultura teatrale e mondo dell'arte in Italia attraverso «Il Dramma» (1925-1973)”, di cui vengono pubblicati in questo volume gli Atti, rappresenta la prima iniziativa di esplorazione sistematica e organica del Fondo Lucio Ridenti, avvalendosi di competenze e sguardi incrociati, nel solco di quel laboratorio di sapere, mestiere e passione che è stato appunto «Il Dramma».

Due to their unique flexibility and high reproducibility, lasers have been traditionally used in processes such as cutting, drilling, machining, welding or cladding. In recent years, with the development of ultrafast laser sources, i.e., laser sources emitting pulses with durations ranging from picoseconds to femtoseconds, lasers also emerged as a new and promising tool for the texturing of virtually all kinds of surfaces. In Chapter One, a brief overview of the lasers and techniques utilised in micro- and nano-surface modifications is presented, followed by a detailed discussion of the surface chemistry and topography effect on bacteria aggregation and adhesion. Also, the role of the laser-induced superficial patterns on the response and sensitivity of bio-implants will be explored in depth. Chapter Two reports on cardiovascular laser application by using the open-irrigated ELMA catheter RytmoLas as an intriguing alternative for catheter ablation of arrhythmias. Chapter Three describes a novel feature designed for ELAI in which different colouration codes for the different metals are applied, enabling a good regional allocation of a specific metal within the tissues. Chapter Four focuses on laser ablation processing of metallic and polymeric thin films used in microelectromechanical systems technology for the fabrication of microfluidic devices with integrated electrodes on printed circuit boards (PCB-MEMS). Chapter Five presents typical micro and nanotextured surfaces created by direct irradiation under stationary and non-stationary conditions and the mechanisms behind their development and growth are discussed. Chapter Six discusses the data about structural and morphological characteristics of nano-sized transition-metal oxides of zirconium and molybdenum produced by laser ablation in water.

Strategies for providing optimal care to this high-risk patient group The immunocompromised patient population is increasing throughout the world. Major advances in transplantation techniques have expanded access to lifesaving therapies and improved outcomes in these high-risk populations. An understanding of the biology of these infections, host conditions, and the limitations of technologies used to detect and quantify such pathogens is critical to optimal care. This new edition of Diagnostic Microbiology of the Immunocompromised Host covers all aspects of state-of-the-art diagnostics for infectious complications in the immunocompromised patient. Editors Randall Hayden, Karen Carroll, Yi-Wei Tang and Donna Wolk, assembled the contributions of a team of preeminent authors to discuss a broad range of topics, including relevant aspects of host biology, antineoplastic, and transplantation techniques and the basis of immunosuppressive conditions ranging from diabetes to age-related immunosuppression approaches, interpretations, and limitations of laboratory diagnosis of infections by a wide range of specific etiologic agents laboratory diagnosis of infections of specific organ systems, such as respiratory tract infections, gastrointestinal tract infections, and central nervous system infections special topics such as prosthetic devices and catheters, healthcare acquired infections, and morphologic considerations (anatomic pathology) future diagnostic technologies and their potential impact on the field Diagnostic Microbiology of the Immunocompromised Host is a resource for laboratory medicine specialists, pathologists, technologists, students, and clinical care professionals who are involved or interested in the care of the immunocompromised host. If you are looking for online access to the latest clinical microbiology content, please visit www.wiley.com/learn/clinmicronow.

This book provides an overview of solar wind turbulence from both the theoretical and observational perspective. It argues that the interplanetary medium offers the best opportunity to directly study turbulent fluctuations in collisionless plasmas. In fact, during expansion, the solar wind evolves towards a state characterized by large-amplitude fluctuations in all observed parameters, which resembles, at least at large scales, the well-known hydrodynamic turbulence.This text starts with historical references to past observations and experiments on turbulent flows. It then introduces the Navier-Stokes equations for a magnetized plasma whose low-frequency turbulence evolution is described within the framework of the MHD approximation. It also considers the scaling of plasma and magnetic field fluctuations and the study of nonlinear energy cascades within the same framework. It reports observations of turbulence in the ecliptic and at high latitude, treating Alfvénic andcompressive fluctuations separately in order to explain the transport of mass, momentum and energy during the expansion. Further, existing models are compared with direct observations in the heliosphere.The problem of self-similar and anomalous fluctuations in the solar wind is then addressed using tools provided by dynamical system theory and discussed on the basis of available models and observations. The book highlights observations of Yaglom's law in solar wind turbulence, which is one of the most important findings in fully developed turbulence and directly related to the long-lasting and still unsolved problem of solar wind plasma heating.Lastly, it includes a short chapter dedicated to the kinetic range of fluctuations, which has recently been receiving more attention from the space plasma community, since this is inherently related to turbulent energy dissipation and consequent plasma heating. It particularly focuses on the nature and role of the fluctuations populating this frequency range, and discusses several model predictions and recent observational findings in this context.

Since the publication of the sixth edition of this benchmark text, numerous advances in the field have been made – particularly in stem cells, 3D culture, scale-up, STR profiling, and culture of specialized cells. Culture of Animal Cells: A Manual of Basic Technique and Specialized Applications, Seventh Edition is the updated version of this benchmark text, addressing these recent developments in the field as well as the basic skills and protocols. This eagerly awaited edition reviews the increasing diversity of the applications of cell culture and the proliferation of specialized techniques, and provides an introduction to new subtopics in mini-reviews. New features also include a new chapter on cell line authentication with a review of the major issues and appropriate protocols including DNA profiling and barcoding, as well as some new specialized protocols. Because of the continuing expansion of cell culture, and to keep the bulk of the book to a reasonable size, some specialized protocols are presented as supplementary material online. Culture of Animal Cells: A Manual of Basic Technique and Specialized Applications, Seventh Edition provides the most accessible and comprehensive introduction available to the culture and experimental manipulation of animal cells. This text is an indispensable resource for those in or entering the field, including academic research scientists, clinical and biopharmaceutical researchers, undergraduate and graduate students, cell and molecular biology and genetics lab managers, trainees and technicians.

The number of diagnosed cases of primary immunodeficiency diseases (PIDs) – a group of inborn disorders of the immune system – is growing rapidly, but misdiagnosis or late diagnosis still occurs in a significant number of patients, with serious consequences. This is the second edition of a practical reference textbook on PIDs that has been widely welcomed by scientists and clinicians from around the world. The new edition has been extensively revised to reflect advances in knowledge and includes various PIDs not previously covered. For each disease, information is provided on definition, etiology, clinical manifestations, diagnosis, and management. This book will represent an ideal resource for specialists when engaging in diagnosis, clinical decision-making, and treatment planning. It will also prove invaluable for doctors in training and other physicians and nurses who wish to learn more about PIDs.

This new book reviews the latest advances in the embryology, genetics, diagnosis, imaging, and therapy of congenital heart disease. The international cast of authors has combined its talents to produce a unique, expert perspective. This publication arrives at a very exciting time when new genetic, imaging, and therapeutic developments are changing the field. It is relevant to pediatricians, internal medicine specialists, medical geneticists, both pediatric and adult cardiologists, embryologists, imaging physicians, and cardiac surgeons. The reader is taken on a journey that begins with a historical overview of congenital cardiovascular anomalies and ends with developments in stem cell and tissue engineering. In between are chapters on cardiac embryogenesis; epidemiology; genetic syndromes associated with cardiovascular anomalies; single gene disorders; cardiac imaging; surgical and interventional therapies; and ethical considerations.'Congenital Heart Disease'is an invaluable reference. In short, it provides essential information to create a comprehensive resource for all physicians involved with the diagnosis and treatment of cardiac malformations.

This book provides an updated overview of agammaglobulinemia, a rare form of primary immunodeficiency which is considered the prototype of the congenital humoral defects, and which is characterized by the absence of peripheral B cells and very low serum immunoglobulin levels. The book opens by discussing the highly orchestrated early B cell development in the bone marrow and the genes involved based on both human and animal models. The pathogenesis and clinical presentation of X-linked agammaglobulinemia, caused by mutations in the BTK (Bruton's tyrosine kinase) gene, are then presented in detail, followed by descriptions of the clinical manifestations and molecular basis of the less frequent autosomal recessive and autosomal dominant forms of agammaglobulinemia. Patients'management in terms of respiratory complications, gammaglobulin replacement therapy and the potential value of novel experimental therapeutic strategies are discussed. The book's closing chapters offer a comprehensive and updated description of mutations in the BTK gene, and the expression and function of BTK in cells other than B cells.

This book will be a guide to understanding resistance against targeted therapeutic approaches for cancer using immunotoxins. It contains a detailed review of the history and development of targeted therapy. As well, it includes an in-depth description of the molecular and cellular mechanisms involved in cancer resistance and several novel methods to overcome resistance. Each chapter discusses different aspects of resistance and covers all the factors that may contribute to resistance in cancer cells. Finally, this volume highlights the recent findings and advances associated with tackling cancer resistance.

This book provides the reader with the knowledge required in order to understand the chemical, physical, mechanical, and topographical aspects of implant surfaces, as well as their impact on the biological response. Common ways to modify implant surfaces are described, and methods for the evaluation of surface properties are presented in an easy-to-read style. Experimental results that have contributed to surface modifications relevant for commercial available implants are presented, with emphasis on in vivo and clinical studies. While the focus is primarily on surface modifications at the micrometer and nanometer levels, alterations at the millimeter level are also covered, including thread designs and their possible influence on stress distribution. In addition, it is analyzed how surface alterations have changed the clinical long-term results for certain groups of patients.

Personalized Epigenetics discusses the core translatability of epigenetics to health management of individuals who have unique variations in their epigenetic signatures that can guide both disorder and disease prevention and therapy. The book details inter-individual variability in the major epigenetic process in humans consisting of DNA methylation, histone modifications, and noncoding RNA, and the diagnostic, prognostic, and therapeutic potential of the field, it also reviews the impact of the environment on epigenetic variations among individuals and the role of pharmacology and drug development in personalized epigenetics. Most importantly, the text covers personalized epigenetics from a disease-oriented perspective, presenting chapters that provide advances in widespread disorders or diseases, including diabetes, cancer, autoimmune disorders, obesity, cardiovascular diseases, neurological disorders, and pain management. - Discusses the core translatability of epigenetics to health management of individuals who have unique variations in their epigenetic signatures - Details inter-individual variability in the major epigenetic process in humans consisting of DNA methylation, histone modifications, and noncoding RNA, and the consequent diagnostic, prognostic and therapeutic potential of the field - Reviews the impact of the environment on epigenetic variations among individuals and the roles of pharmacology and drug development - Devotes several chapters to the advances made in widespread disorders or diseases, including diabetes, cancer, autoimmune disorders, obesity, cardiovascular diseases, neurological disorders, and pain management

Primäre Immundefekterkrankungen (PID) sind seltene, angeborene Erkrankungen. Sie manifestieren sich fast immer durch ungewöhnliche Infektionen oder Infektionskomplikationen. Aufgrund ihrer Komplexität - aber auch, weil PID als seltene Erkrankungen häufig nicht in differentialdiagnostische Überlegungen einbezogen werden - erfolgt ihre Diagnosestellung oft erst mit Verzögerung. Die gezielte Therapie der betroffenen Patienten erfolgt dann erst spät, wenn zum Teil bereits irreversible Schäden, z.B. durch häufige Infektionen und deren Komplikationen, eingetreten sind. Darüber hinaus können Immundefekte aber auch akut durch schwerste Infektionen lebensbedrohlich verlaufen. Ziel des vorliegenden Buches ist es, die Diagnose, Therapie und Prophylaxe von Infektionen bei primären Immundefekterkrankungen zu beschreiben. Die Auswahl der aufgenommenen PID orientiert sich an der aktuellen IUIS (International Union of Immunological Societies)-Klassifikation, ohne sich hierauf zu beschränken. Ausgehend von einer kurzen Beschreibung des zugrunde liegenden Immundefektes werden typische Infektionsmuster sowie deren Diagnose, Therapie und Prophylaxe beschrieben.

Molecular Aspects of Aging: Understanding Lung Aging covers recent research in the mechanisms that contribute to cellular senescence. Covering universal themes in aging, such as the exhaustion of stem cells and subsequent loss of the regenerative refueling of organs as well as immunosenescence, this text illuminates new directions for research not yet explored in the still poorly investigated area of molecular mechanisms of lung aging. The molecular nature of general aging processes is explored with targeted coverage on how to analyze lung aging through experimental approaches.

This new book synthesizes a wide range of interdisciplinary literature to provide the state-of-the art of biomedical implants. It discusses materials and explains the three basic requirements for implant success from a surface engineering perspective: biological compatibility, biomechanical compatibility, morphological compatibility. Biomedical, mechanical, and materials engineers will find this book indispensable for understanding proper treatment of implant surfaces in order to achieve clinical success. Highlights include: • Coverage of surface engineering of polymer, metallic, ceramic and composite implant materials; • Coverage of chemical, mechanical, physical, thermal, and combined surface modification technologies; • Explanations of interfacial reaction between vital tissue and non-vital implant surface; and • Methodologies and technologies for modification of surface layer/zone to promote the osteo-integration, the ultimate success for biomedical implants in both dental and medical practice.

The application of molecular technology in clinical diagnosis is a rapidly developing area and is predicted to greatly improve the speed, efficiency and accuracy of diagnostic medicine.The editors of this book have commissioned an excellent series of chapters representing two key molecular diagnostic areas: cancer and infectious diseases. The cancer section deals with the challenges in identifying genetic, epigenetic and transcriptomic biomarkers. The infectious disease section describes the current clinical applications of molecular diagnostics for the detection of viral, bacterial and fungal pathogens as well as an example of the use of molecular diagnostics outside the clinic environment. A cautionary tale describing what can go wrong when molecular methods are applied incorrectly is also provided and makes fascinating reading. A substantial component of the book is dedicated to the process of translating a preclinical test to the bedside and describes the progress in the near patient point-of-care molecular diagnostics market. This is a fundamental consideration for successful translation of diagnostics tests from bench to bedside and is crucial for molecular diagnostics to have an impact on patient care. The final chapter offers a prediction of future trends in the molecular diagnostics of infectious diseases.This volume is essential reading for anyone involved in the development or application of molecular diagnostics and is recommended for all clinical diagnostics laboratories.