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This book examines the impact of climate change on eye disease and eye health.Filling a lacuna in the existing literature, Scott Fraser takes a deep dive into the eye diseases that are most affected by the climate crisis and explores the subsequent burden on organisations, charities and healthcare systems. Fraser begins by including short primer chapters on the basics of climate science and climate change, highlighting which environmental mechanisms directly and indirectly affect our health and why. He then looks in detail at the direct and indirect threats to eye health from climate change and examines factors including changing insect vectors, trauma from extreme weather events such as wildfires, floods and droughts, as well as the impact of crop failure, malnutrition, animal and plant migration. Highlighting the Global North vs South divide, the book goes on to consider issues around eye care, exploring the increased burden that climate-induced chronic eye diseases including cataracts, macular degeneration and nutritional eye diseases are placing on health care systems. These chapters also reflect on the ways in which eye care, ophthalmology, optometry, pharmaceutical and medical device companies all contribute to the climate footprint themselves.Unique and timely, this book will be a great resource for students and clinicians of ophthalmology, optometry and allied eye care professions, as well as climate scientists, researchers, policy makers, charities, NGOs working in related fields of environment and health.

This book gathers selected high-quality research papers presented at the Ninth International Congress on Information and Communication Technology, held in London, on February 19–22, 2024. It discusses emerging topics pertaining to information and communication technology (ICT) for managerial applications, e-governance, e-agriculture, e-education and computing technologies, the Internet of Things (IoT), and e-mining. Written by respected experts and researchers working on ICT, the book offers an asset for young researchers involved in advanced studies. The work is presented in ten volumes.

This is an updated and comprehensive treatise on optical, medical, and surgical management of keratoconus with an exclusive panoramic view of all existing modalities for confronting this serious disabling morbidity affecting people in their youth. Early diagnosis and proper treatment can salvage vision and help patients to get back to their routines and enhance their quality of life. The contents include optical and glass prescription and contact lens fitting; CXL alone; and combined surgeries, phakic IOLs, and corneal transplantation. The illustrated and organized 360-degrees approach makes this a must-have manual for ophthalmology trainees, fellows, and professionals.Key Features: Focuses on optical management for keratoconus, with the latest updates on surgical management Covers a very interesting and relevant topic for ophthalmologists and cornea specialists, using a practical case-based format Uses evidence-based algorithms from updated published data and insights from experienced authors

This concise practical guide is designed to facilitate the clinical decision-making process in the management of atopic dermatitis by reviewing a number of cases and defining the various diagnostic and management decisions open to clinicians. It is well illustrated and diverse in scope, enabling the reader to obtain relevant information regarding both standard and unusual cases in a rapid, easy to digest format. Each case includes a narrative description and patient management tips along with a relevant board review question. This book covers exciting updates in the diagnosis and management of AD such atopic dermatitis spectrum disorder and the effects of internal vessel inflammation in AD patients. It also highlights the newest oral, biologic and topical therapies (along with pipeline therapies) in the treatment of atopic dermatitis. Clinical Cases in Atopic Dermatitis is a must-have resource for dermatologists, dermatology residents, fellows, medical students, nurse practitioners and physician assistants, as well as allergists and immunologists.

Written and designed to enhance your understanding of ocular function, structure, and anatomy, Adler's Physiology of the Eye is a classic, best-selling text that makes critical information easier to learn and retain. The fully revised 12th Edition continues the successful Adler's approach that connects basic science and clinical aspects in a user-friendly, highly visual format—ideal for study, review, and exam preparation. It captures the latest molecular, genetic, and biochemical discoveries and offers you unparalleled knowledge and insight into the physiology of the eye and its structures. - Covers the full structure and function of the eye and its related anatomy and makes the connection between physiology and clinical practice. - Includes major updates throughout, including new information on OCT/OCTA imaging, new drug delivery methods, ocular biomechanics, and evolving gene therapies. - Organizes content by function, rather than anatomy, to help you make a stronger connection between physiological principles and clinical practice. - Explains the physiological principles that underlie visual acuity, intraocular pressure, ocular circulation, the extraocular muscles, and much more. - Features approximately 1,000 illustrations throughout, including medical artwork; schematics, charts, and graphs; clinical photographs; and more. - Any additional digital ancillary content may publish up to 6 weeks following the publication date.

This book reviews the etiology of major zoonotic diseases, their impact on human health, and control mechanisms for better management. It also examines factors influencing transmission, diagnosis, treatment, management, and prevention of zoonotic diseases caused by different human pathogens, including bacteria, viruses, fungi, protozoans, and parasites. It also introduces zoonoses with a wildlife reservoir and discusses different transmission modes, and factors that influence the epidemiology of zoonoses. It further discusses the holistic strategies for the cost-effective prevention and control of these zoonoses. Towards the end, the book also discusses infections that have spread from non-human primates to humans and strategies to improve disease control and elimination. This book is very useful for students, academicians, and researchers of veterinary sciences, veterinary medicine, and, veterinary public health.

A comprehensive guide for integrating pathology into a clinical setting. Pathological Basis of Oral and Maxillofacial Diseases presents the basic principles involved in disease mechanisms in an easy-to-understand way. By integrating recent advances in molecular, immunologic, and genetic understanding of oral disease, the book helps readers enhance their knowledge and its application in a clinical setting. This book is divided into nine sections, covering key topics such as inflammation, genetic diseases, and neoplasia, with contributions from over 50 international authors. Diagrams, clinical, radiographic, and histopathology images and tables supplement the text, and the editors have ensured a consistent approach throughout. Topics covered in Pathological Basis of Oral and Maxillofacial Diseases include: The influences of nutrition and the environmentCellular structure and function, causes and mechanisms of cellular pathology.Immunity and host defence mechanisms, immune dysfunctions affecting the oro-facial complex.Inflammation and inflammatory diseases of the oro-facial complex Human microbiome, with reference to dysbiosis in dental caries and periodontal diseasesOral manifestations of systemic diseases and the oral-systemic link and its impact on general and oral health Oral potentially malignant and malignant disorders that are a major threat to global public health. Bridging the gap in dental training programs from basic medical science in the initial years to clinical practice, Pathological Basis of Oral and Maxillofacial Diseases is an essential reference for dental students, trainees and practitioners seeking to grasp the pathological basis of disease and apply that knowledge to the oral and maxillofacial regions.

Section 8 discusses the structure and function of the cornea and external eye and reviews relevant examination techniques. Includes the latest statistics on indications for corneal transplants from the Eye Bank Association of America. Covers infectious and ocular surface diseases; disorders and surgery of the ocular surface; immune-mediated and neoplastic disorders; and congenital anomalies and degenerations. A chapter on the genetics of corneal dystrophies reflects the IC3D classification. Toxic and traumatic injuries and corneal transplantation are also reviewed. Also covers the latest diagnostic imaging technologies, endothelial replacement surgery updates and best practices for sebaceous cell carcinoma early recognition and treatment.

Sex/gender-specific medicine (SGM) is defined as the practice of medicine based on the understanding that biology and social roles are important in men and women for prevention, screening, diagnosis, and treatment. Current research demonstrates differences in disease incidence, symptomatology, morbidity, and mortality depending on sex and gender. Sex/gender-specific medicine is a fundamental aspect of tailored therapy and precision medicine. Therefore, the variables must be considered in medical education and practice as well as in research models ranging from human participants, animals and cells. This concept could be applied in the whole clinical areas from Neuroscience, Psychiatry, Gastroenterology, Cardiology, and Rehabilitation, etc. Nowadays estrogen is known to play a key role in the prevention of colon cancer and in the resistant progression of liver cirrhosis and hepatocellular carcinoma, especially in women. This book covers the sex/gender-specific medicine in the whole clinical areas in the adults as well as in the pediatrics. In addition, research results of basic science are also introduced in the colon cancer and Alzheimer's disease.

The book covers antimicrobial resistance in ocular diseases, including the microbiology of the ocular surface, the history and origin of antimicrobials, methods to detect antimicrobial resistance and antimicrobial resistance genes, and the impact of antimicrobial resistance on a variety of ocular diseases. The inclusion of chapters covers bacterial keratitis, fungal keratitis, viral keratitis, acanthamoeba keratitis, endophthalmitis, dry eye disease, post fever retinitis, and uveitis including management and prevention of antimicrobial resistance.Key Features: Focusses on various ocular diseases and their association with antimicrobial resistance; Includes data relevant to drug industry to develop drugs for specific ophthalmic use; Illustrates ocular surface microbiome under various diseased condition;s Highlights the microbes associated with the conjunctiva and cornea of the human eye; Enumerates the changes in the abundance and diversity of the antimicrobial resistant (AMR) microorganisms in the diseased eye. This book is aimed at professionals and researchers in ophthalmology, microbiologists, infectious disease specialists, and public health.

THE authoritative guide for clinical laboratory immunology For nearly 50 years, the Manual of Molecular and Clinical Laboratory Immunology has been the premier resource for laboratories, students, and professionals involved in the clinical and technical details of diagnostic immunology testing. The 9th Edition continues its tradition of providing comprehensive clinical and technical information on the latest technologies used in medical and diagnostic immunology. Led by a world-renowned group of authors and editors, this new edition reflects substantial changes aimed at improving and updating the Manual's utility while reflecting the significant transformations that have occurred since the last edition, including the revolution of gene editing and the widespread adoption of molecularly engineered cellular therapies. Topical highlights include: Laboratory Management: three new chapters cover essential aspects of quality assurance, quality improvement, and quality management, aligning with the increasingly stringent and demanding regulatory environment.Inborn Errors of Immunity: the primary immunodeficiency section has been completely updated to align with the latest International Union of Immunological Societies'classifications of inborn errors of immunity.Functional Cellular Assays: expanded content includes detailed discussions on various functional assays critical for modern immunologic testing.Autoimmune Diseases: expanded chapters on systemic and organ-specific autoimmune disorders, including new chapters on Sjögren's syndrome and deficiency of ADA2, as well as significant updates on organ-specific autoimmune diseases.Transplantation Immunology: updated chapters detail the assessment of immune reconstitution and ABO testing, reflecting latest practices. The 9th Edition of the Manual of Molecular and Clinical Laboratory Immunology serves as an invaluable resource for laboratory directors, clinicians, laboratory managers, technologists, and students. It provides critical insights into the selection, application, and interpretation of immunologic tests, offering practical guidance on troubleshooting, clinical application, and an understanding of test limitations. This comprehensive and up-to-date manual remains an essential tool for anyone involved in the diagnosis, evaluation, and management of immune-mediated and immune system-related disorders.

Endoscopic transorbital surgery of the orbit, skull base and brain is a new surgical discipline that has developed over the last decade out of a collaboration between otolaryngologists, neurosurgeons and oculoplastic surgeons. Tumors and other pathology of the skull base are some of the most difficult to approach and treat for surgeons since they lie at the interface of several traditional specialties, namely the eye, the paranasal sinuses and the brain. For this reason, no single surgical specialty is fully trained to independently reach this region, which requires collaborative approaches that are technically demanding and often long and arduous procedures. In the last decade, using the endoscopic techniques and instrumentation, otolaryngologists, oculoplastic surgeons and neurosurgeons, have together shown that the orbit can be used as a minimally disruptive corridor to reach the skull base lateral to the carotid artery as well as other areas that are difficult to access through transcranial or endonasal approaches. These approaches are now even being used to remove brain tumors involving the frontal and temporal lobes, including those that extend through the middle cranial fossa and into the posterior fossa, without visible external scars or the need for a traditional craniotomy. In addition, they have been used to clip aneurysms, treat seizure disorders, drain abscesses, repair CSF (brain fluid) leaks, and restore skull fractures – all without the additional risks, trauma and prolonged recovery of previous open surgical techniques. The literature is now demonstrating that these endoscopic procedures have comparable or improved safety compared to open surgery, while creating less collateral damage, and result in reduced patient stays. Due to their novelty, few surgeons have acquired the necessary experience, knowledge and expertise to introduce these approaches into their practice, yet due to their safety and efficacy they are rapidly becoming a critical skill set. This is the first text of its kind to codify and proliferate these new approaches more rapidly through the country and world, appealing to otolaryngologists, oculoplastic surgeons and neurosurgeons who deal with pathology involving the skull base.

The Rose-Mackay Textbook of Autoimmune Diseases, Seventh Edition is a comprehensive reference that emphasizes the'3 P's'of 21st Century medicine: precision, prediction, and prevention. Topics cover the modern systems approach to biology that involves large amounts of personalized, ongoing physiologic data ('omics') coupled with advanced methods of analysis, new tests of genetic engineering, such as CRISPR, auto inflammatory diseases, autoimmune responses to tumor immunotherapy, and information on normal immune response and disorders. Each of the major autoimmune disorders is discussed by researchers and clinical investigators experienced in dealing with patients. This new edition continues its success with 75% of the content revised, updated, or completely new. This edition is a valuable resource to clinicians involved in the diagnosis and treatment of autoimmune disease, as well as to scientists who want to follow developments in the field. - Provides new research on autoimmune diseases, their diagnosis, prevention, and therapy - Covers a complete range of all common, rare and new autoimmune diseases, including cancer and COVID - Extensively revised with 75% new material based on autoimmunity, developments in the different diagnosis and therapies for these autoimmune diseases, and a completely updated description of the different diseases - Supplemented with a website that hosts a Podcast per chapter

Dit boek beschrijft de diagnostiek en behandeling van 240 veelvoorkomende kleine kwalen in de huisartsenpraktijk. Het zijn relatief onschuldige aandoeningen, zoals kale plekken op het hoofd, platvoeten of een koortslip. Hierbij volstaat vaak uitleg en een eenvoudig advies.Het boek is bedoeld voor huisartsen (in opleiding), praktijkondersteuners, physician assistants, klinisch verpleegkundigen en medisch studenten.In Kleine kwalen in de huisartsenpraktijk wordt iedere aandoening aan de hand van een vaste en overzichtelijke structuur behandeld. De diagnostiek en het beleid zijn voorzien van een rationele en, zo mogelijk, een wetenschappelijke onderbouwing. Bij vrijwel alle kwalen is ook een illustratie aanwezig. Aan deze editie zijn vier nieuwe hoofdstukken en diverse nieuwe tekeningen en foto's toegevoegd. Daarnaast is al deze informatie nu ook online beschikbaar via Kleine Kwalen Online. De redactie van Kleine kwalen in de huisartsenpraktijk bestaat uit Just Eekhof, Sjoerd Bruggink, Annemarije Kruis, Tobias Bonten en Annelieke Petrus. Redactie en auteurs hebben expertise als huisarts en onderzoeker/docent huisartsgeneeskunde.

Discusses the structure and function of the cornea and external eye and reviews relevant examination techniques. Includes the latest statistics on indications for corneal transplants from the Eye Bank Association of America. Covers infectious and ocular surface diseases; disorders and surgery of the ocular surface; immune-mediated and neoplastic disorders; and congenital anomalies and degenerations. A chapter on the genetics of corneal dystrophies reflects the IC3D classification. Toxic and traumatic injuries and corneal transplantation are also reviewed. Also covers the latest diagnostic imaging technologies, endothelial replacement surgery updates and best practices for sebaceous cell carcinoma early recognition and treatment.

This book builds upon the first edition with new and improved chapters. The book explores the rich assemblage of clinical wisdom from expert rheumatologists from a wide range of specialties including Vasculitis and Sjogren's syndrome. It examines the nuggets or ‘pearls'of wisdom gained from collective clinical experience about the diagnosis or treatment of various diseases whilst also aiming to debunk myths that have influenced the practice of rheumatology by many clinicians. The second edition of A Clinician's Pearls and Myths in Rheumatology is a critical resource for both practitioners and students of rheumatology. This book provides a clear guide for those wishing to take a “deep dive” into the diagnostic and therapeutic elements of rheumatology.

This volume deals with the various fabrication techniques, surface functionalization and biomedical applications of polymeric fibers possessing different scale and structure. It provides an overview of fabrication techniques such as Co-axial, Centrifugal, Melt and Yarning to procure multiscale, tubular and layered fibrous scaffold employed for biomedical applications. The chapters in this volume discusse the surface/chemical functionalization of fibers which enhance the biological properties of the fibrous scaffolds as well as the development of hybrid, layered and external stimuli-responsive fibrous scaffolds that hold potential application in biosensor and other biomedical fields. In addition, recent advances and applications of polymeric multiscale fibers in tissue engineering, regenerative medicine and drug delivery are presented. The potential use of fibrous scaffolds in bone, neural, tendon/ligament and cardiac tissue engineering, nanofibers as an antimicrobial wound dressing, employed in cancer theragnostics and in the treatment of skin/periodontal infections are discussed. The volume provides expert knowledge on the fabrication techniques, development of different scale and hybrid structure fibers, surface functionalization, layered and external stimuli responsive fibrous scaffolds. It will be beneficial to material/biomaterials scientists, bioengineering and biotechnologists by providing a better understanding on the subject of the innovative applications of fibrous scaffolds in drug delivery, tissue engineering, wound dressings and regenerative medicine.

This handbook is a practical guide covering pertinent topics in the specialty of Oral Medicine, which focuses on the diagnosis, prevention, and management of local and systemic conditions affecting the oral and maxillofacial region. Each topic covers a specific disease or disorder with overarching emphasis on diseases presenting with oral mucosal involvement and orofacial pain conditions. Each topic is presented as a summary of key clinical information for quick reference prepared by leading experts in the field. This clinical guide will serve as a valuable resource for students and clinicians in practice.

Ocular surface diseases in children have not always been well understood and the literature in this age group is limited. The consequences of misdiagnosis and delayed diagnosis include visually significant scarring and amblyopia, thus with real impact on their quality of life and ultimate visual potential. Recently, there has been an increase in clinical and research focus on these diseases, contributing to a growing awareness of their importance to pediatric visual health. This book is the first comprehensive volume dedicated to pediatric ocular surface diseases. It provides an up-to-date and highly illustrated discussion of the pathophysiology, symptomatology and diagnostic and therapeutic strategies of these less commonly understood diseases, in a format that is readily absorbed by trainees and seasoned physicians alike. The aim of this book is to provide a practical and detailed understanding of ocular surface disease in the pediatric population,as many of these corneal conditions in children require unique therapeutic approaches and may have subtle presentations. Chapters will address key issues, such as dry eye disease, Steven Johnson Syndrome and neurotrophic keratitis, that can have a profound impact on children's visual and social development. Pediatric Ocular Surface Disease is a must-have resource for pediatric ophthalmology fellows, cornea fellows, pediatric ophthalmologists, and cornea specialists.

In 2020 we lost Noel Rose, co-editor of the classic Infection and Autoimmunity. To honor and respect his work, a group of experts in the field have taken the initiative to make this book perpetual. The third edition of Infection and Autoimmunity updates all the recent and leading papers on infection and autoimmunity, in addition to a dedicated section on to the correlation between SARS-CoV-2 infection and autoimmunity. From the very beginning of the COVID-19 pandemic, numerous papers have been published, including studies conducted by the editors and authors of the book, on COVID-19 and autoimmunity, and therefore this knowledge has been incorporated into this new edition. The addition and extended coverage on SARS-CoV-2/COVID-19 and autoimmunity are pivotal for the third edition of the book due to the COVID-19 pandemic. Medical students and practitioners, as well as academic staff in medical schools globally, are enthusiastic in searching for better understanding of the correlation between infection and autoimmunity in general, and the long-term effects of SARS-CoV-2 and COVID-19 on the immunce system in particular, especially in terms of autoimmunity related to the virus. - Fully revised and updated by a global group of experts, dedicated to and in honor of Noel Rose - Includes 52 completely updated chapters with the latest developments in the field - Is the only book directed specifically at the interactions between infectious agents and autoimmunity - Describes the prevalence and incidence of global issues and current therapeutic approaches - Addresses in full, details of the mechanisms behind the emergence of autoimmune diseases secondary to infections - Brings the reader up-to-date and allows easy access to individual topics in one place

Discover more about permanent make-up and medical tattooing in the new book ‘Cosmetic and Medical Tattoos', part the book series ‘Current Problems in Dermatology'. This comprehensive book covers a broad range of techniques and applications; brows, eyeliners, lips; areola and nipple after breast surgery, scar camouflage and 3D reconstruction. Contributions are made by internationally esteemed permanent make-up masters and medical experts. This collection is a milestone and unique source of information to cosmetic tattoo practitioners as well as medical specialists, who recognise the importance of aesthetic intervention to complement otherwise successful treatment.

Designed to enhance the learning experience for both practicing otolaryngologists and otolaryngology residents, Bailey's Head & Neck Surgery—Otolaryngology, 6th Edition, delivers concise, practical information in all areas of this complex field. Dr. Clark A. Rosen (Laryngology) and his hand-picked editorial team representing all of the sub-disciplines of Head & Neck Surgery-Otolaryngology of Drs. Stacey Gray (rhinology), Patrick Ha (Head and Neck Surgery), Charles Limb (Otology), Stephen Park (Facial Plastics and Reconstructive Surgery), and Gresham Richter (Pediatric Otolaryngology) ensure that all content in this two-volume text is current, useful, and evidence based. Each chapter has been written to increase the reader's understanding, retention, and ability to successfully apply information in everyday practice.

Discusses the structure and function of the cornea and external eye and reviews relevant examination techniques. Includes the latest statistics on indications for corneal transplants from the Eye Bank Association of America. Covers infectious and ocular surface diseases; disorders and surgery of the ocular surface; immune-mediated and neoplastic disorders; and congenital anomalies and degenerations. A chapter on the genetics of corneal dystrophies reflects the IC3D classification. Toxic and traumatic injuries and corneal transplantation are also reviewed. Also covers the latest diagnostic imaging technologies, endothelial replacement surgery updates and best practices for sebaceous cell carcinoma early recognition and treatment.

This book offers every clinical ophthalmologist complete guidance as it compiles the results of the latest multicenter clinical trials in the practice of ophthalmology with relevant references. The trials have been organized into chapters, covering all ophthalmic sub-specialties. Each pertinent trial is described under similar subject headings/styles and has been formatted accordingly for easy reading and recall. A summary at the end of each chapter has been provided for easy reference. All the major and latest clinical trials have been recorded.

Tremendous advances have been made in the field of rheumatology, profoundly changing our understanding of many rheumatologic conditions and creating a new frontier for effective treatments. This book explains the most significant advances in research and care and speculates as to what will be the future of rheumatology over the next several decades, including challenges and lessons learned from past experiences in the field. It highlights landmark research articles and scientific discoveries, discusses how big data, personalized medicine, new biomarkers for disease, and other technological revolutions will shape the future, making it a must-have resource for physicians from all regions of the world. Key Features• Includes concise yet thorough description of the landmark studies and scientific breakthroughs coupled with easy-to-follow organizational structure of chapters that are accessible to readers at different levels of training.• Brings together world-leading experts to provide a fresh perspective to trainees such as residents and fellows-in-training, as well as more senior clinicians and researchers across the field of rheumatology and in specialties such as cardiology, dermatology, pulmonology, nephrology, and neurology, all of whom care for patients with rheumatologic conditions.• Allows the authors to imagine and speculate about the evolution of the field of rheumatology in the coming decades. Examples of such speculative possibilities include use of synovial biopsy to predict response to treatment in rheumatoid arthritis, replacement of renal biopsy with urinary proteomics in diagnosing and classifying lupus nephritis, use of new therapeutics to obviate the need for steroids in the treatment of ANCA-associated vasculitis, and the use of machine learning to evaluate subtle changes in imaging for management of inflammatory arthritis.

This book provides an integrated review of the human ocular microbiome. It documents the discovery of ocular surface microbes by the conventional cultivable method and next generation sequencing technologies in both healthy and diseased (keratitis, uveitis, endophthalmitis, blepharitis, conjunctivitis etc.) eyes. The book further discusses the confounding factors that influence the microbiome, mycobiome and virome. The chapters cover niche-specificity with reference to skin, eyelid- margin, hands etc. It highlights the concept of core genera, dysbiosis and discriminating genera and covers the functional relevance of the dysbiotic microbiome, mycobiome and virome with respect to ocular diseases. The book includes topics on the relevance of molecular mechanisms, including quorum-sensing and mucin metabolism to ocular disorders, such as dry eye; and, microbiome-based therapies for treating of ocular disorders like vernal keratoconjunctivitis. The book is essential for microbiologists studying the human eye, ophthalmologists treating eye infection and trauma. It also caters to students of medical microbiology and medicine.

Afflicting one in 83 Americans, Sjögren's is a serious and systemic autoimmune disease that, along with symptoms of extensive oral and ocular dryness, can lead to other serious complications including profound fatigue, chronic pain, major organ involvement, neuropathies and lymphoma. While there is no cure for Sjögren's, approaches exist to help manage and treat aspects of the disease, and this revised handbook offers everything readers need to understand and cope with their diagnosis. The Sjögren's Book, Fifth Edition is a comprehensive and authoritative guide, produced by the Sjögren's Foundation and its medical advisors and edited by a leading authority on autoimmune disorders. This expanded edition provides readers with the best medical and practical information on this disease, bringing together current thinking about Sjögren's in an easily readable and understandable book and providing important new content on areas not covered in previous editions. With more than fifty chapters written by leading experts, this handbook illuminates the major clinical aspects of the disease and is loaded with practical tips and advice as well as scientific advancements in the field. Indeed, it offers a wide-ranging look at the many faces of Sjögren's, covering diagnosis, the many organ systems that can be affected, emotional burden and management, treatment options, and hope for the future. Recognized as the bible for Sjögren's sufferers, this reliable and informative guide is the first place for patients to look when they have questions about this disabling disease. It is a valuable aid that patients can use while discussing their illness with their physician and an excellent resource for family members. Because Sjögren's is greatly underdiagnosed, this handbook is a particularly valuable resource for healthcare professionals.

Offering practical clinical guidance for early diagnosis and effective management, Keratoconus: Diagnosis and Management is a concise, easy-to-read guide to help mitigate loss of vision in patients in a way that does not interfere with quality of life. From early diagnosis and intervention through the most up-to-date treatment and surgical approaches, this consolidated reference covers the essential information needed by cornea fellows and specialists, general ophthalmologists, residents, and optometrists. Provides expert, step-by-step guidance and real-world perspectives from global contributors in the field. Covers the latest advances in cornea transplantation, corneal collagen cross-linking (CXL) in adult and pediatric patients, intrastromal corneal rings, intraocular lenses, corneal regeneration, and laser surgery. Includes quick-reference boxes throughout highlighting essential clinical facts, pitfalls, potential complications, and clinical guidelines. Presents real-world case studies of actual patient scenarios from early to advanced disease states. Features high-quality imaging for keratoconus at various stages, including OCT, Brillouin scanning microscopy, Scheimpflug and combined Placido and Scheimpflug, combined Placido and AS-OCT, clinical and surgical photos, and more.

Keeping up to date with advances in comprehensive ophthalmology and in the ophthalmic sub-specialties is extremely difficult because of the accelerating rapidity with which new information and technology become available and the diminishing time and opportunity for practitioners and trainees to read and learn. The first edition of Albert and Jakobiec's Principles and Practice (1994) was conceived with the idea of utilizing an electronic, updated version in which the chapters were revised by the chapter authors on an annual or semi-annual basis, but the technology was not sufficiently advanced to achieve this goal. Subsequent editions (2000 and 2008) were organized by Saunders and the last published by Elsevier (of which Springer has obtained the complete rights to move forward with the 4th edition). For nearly three decades, this text has provided its readers with authoritative and comprehensive coverage of clinical ophthalmology, written and edited by a group of authors who represented a “Who's Who” in ophthalmology. By using Springer's Meteor platform, with its ability to allow authors and editors access to updating their chapters online annually/semi-annually, and with the recruitment of select chapter authors, this work's usefulness as the standard text in ophthalmology will be maintained and expanded upon by Springer. The 4th edition of this comprehensive and authoritative text is written by hundreds of the most distinguished authorities from around the world and edited by four leaders in the field, providing today's best answers to every question that arises in ophthalmology practice. Richly illustrated with thousands of high quality, full color, clinically-relevant images, Albert and Jakobiec's Principles and Practice of Ophthalmology, 4th Edition covers every scientific and clinical principle in ophthalmology, ensuring that the reader will always be able to find the guidance needed to diagnose and manage patients'ocular problems and meet today's standards of care. Written for practicing ophthalmologists and trainees, this book delivers in-depth guidance on new diagnostic approaches, operative techniques, and treatment options, as well as coherent explanations of new scientific concept and its clinical importance. The 4th edition will prove to be the source every practicing clinician needs to efficiently and confidently overcome any clinical challenge they may face. Updates include new chapters on anterior and posterior segment diseases, as well as chapters more focused on treatment, plus thousands of new, high-quality, color images and illustrations, updated references, and information on the most cutting-edge technology used by clinicians in their practices today. Additionally, readers will enjoy the same, user-friendly, full-color design they remember from the previous edition, complete with many at-a-glance summary tables, algorithms, boxes, and diagrams that allow the reader to locate the assistance needed more rapidly than ever.

This book answers questions about the critical role of ultrasound in the management of patients with Sjögren's syndrome. It also covers developments rheumatologists can foresee in performing a biopsy of the parotid gland. Each chapter is authored by experts on this condition, emphasizing the extent of current understanding and dealing with unanswered challenges and pitfalls. Topics such as modern imaging techniques like ultrasound and MRI and their importance are given particular focus in this book; practitioners are increasingly using imaging techniques to refine diagnosis and guide clinical management. Additionally, as a significant emerging point of interest in the field, biopsy of the major salivary glands, particularly ultrasound-guided procedures, receives extra attention within the text. The book also includes a chapter that deals with future directions and will also review the challenges patients face with unmanaged Sjögren's syndrome. Comprehensive and concise, Sjögren's Syndrome and the Salivary Glands provides a balanced overview between the chapters and ensure homogeneity of the terminology.

Curbside Consultation in Cornea and External Disease, Second Edition contains new questions and brief, practical, evidence-based answers to the most frequently asked questions that are posed during a “curbside consultation” between clinicians. Dr. David R. Hardten and associate editors Drs. Mark S. Hansen and Celine Satija have designed this unique reference in which cornea and external disease specialists offer expert advice, preferences, and opinions on tough clinical questions commonly encountered by corneal specialists, ophthalmologists, or residents. The unique Q&A format provides quick access to current information with the simplicity of a conversation between two colleagues. Numerous images, diagrams, and references are included to enhance the text and illustrate clinical diagnoses and treatment plans. Some of the questions that are answered inside the Second Edition include: I have a patient with Fuchs'Endothelial Dystrophy. Is there anything new to improve her vision? What should I do with a young patient with mild keratoconus? How can I help a 47-year-old female who uses artificial tears 6 times daily and continues to complain of dry eyes? A patient presents with corneal ulcer. What work-up and treatment would you recommend? How do I manage a patient that rubbed their eye just after LASIK? What could go wrong? What can I offer a patient that sustained eye trauma and loss of iris tissue? I have a patient with poor vision after DMEK. What went wrong and how do I get better vision for them? Curbside Consultation in Cornea and External Disease: 49 Clinical Questions, Second Edition provides information basic enough for residents while also incorporating expert pearls that even high-volume ophthalmologists will appreciate. Cornea specialists, general ophthalmologists, and residents alike will enjoy the user-friendly and casual format and the expert advice contained within.

Known for its concise, easy-to-read writing style and comprehensive coverage, Cecil Essentials of Medicine has been a favorite of students, residents, and instructors through nine outstanding editions. This revised 10th Edition continues the tradition of excellence with a focus on high-yield core knowledge of key importance to anyone entering or established in the field of internal medicine. Fully revised and updated by editors Edward J. Wing and Fred J. Schiffman, along with other leading teachers and experts in the field, Cecil Essentials remains clinically focused and solidly grounded in basic science. - New focus on high-yield, core knowledge necessary for clerkships or residencies in medicine, with concise, complete coverage of the core principles of medicine and how they apply to patient care. - Each section describes key physiology and biochemistry, followed by comprehensive accounts of the diseases of the organ system or field covered in the chapters. - Full-color design enhances readability and retention of concepts, while numerous imaging videos cover cardiovascular disease, endoscopy, sphincterotomy, and more. - Superb images and photographs vividly illustrate the appearance and clinical features of disease. - New chapters cover Women's Cancer and Transitions in Care from Children to Adults with Pulmonary Disease.

Kleine kwalen en alledaagse klachten bij ouderen geeft een praktische leidraad voor zestig alledaagse klachten bij mensen van ongeveer 75 jaar of ouder. Diagnostiek en beleid krijgen een rationele en, zo mogelijk, een wetenschappelijke onderbouwing. De inhoud sluit aan bij de richtlijnen en standaarden van het Nederlands Huisartsen Genootschap (NHG). In het boek wordt iedere aandoening aan de hand van een vaste en overzichtelijke structuur behandeld. Elk hoofdstuk begint met kernpunten die de belangrijkste aspecten van de aandoening in een oogopslag bij elkaar zetten. Aan vrijwel ieder hoofdstuk zijn illustraties toegevoegd. Aan deze geheel herziene editie zijn 10 nieuwe hoofdstukken toegevoegd en is veel nieuw beeldmateriaal opgenomen. Daarnaast is al deze informatie ook online beschikbaar via Kleine Kwalen Online. Kleine kwalen en alledaagse klachten bij ouderen is bedoeld voor de huisarts (in opleiding), de specialist Ouderengeneeskunde (in opleiding), de praktijkondersteuner en de wijkverpleegkundige. Het boek is ook waardevol voor andere professionals die betrokken zijn bij de medische zorg voor ouderen en net zoals de andere kleine kwalen boeken is het boek ook interessant voor medisch studenten. De redactie van dit boek was in handen van Just Eekhof, Sjoerd Bruggink, Marissa Scherptong – Engbers, Annemarije Kruis en Tobias Bonten. De redactieleden hebben expertise als praktiserend huisarts, onderzoeker en docent huisartsgeneeskunde. Met veel dank voor hun medewerking aan - dr. Tony Poot, hoofd van de NHG-kaderopleiding Ouderengeneeskunde, en - prof. dr. Wilco Achterberg hoogleraar Institutionele zorg en ouderengeneeskunde beiden werkzaam bij de afdeling Public health en Eerstelijnsgeneeskunde LUMC.

Offering up-to-date, comprehensive coverage of disease progression, diagnosis, management, and prognosis, Textbook of Pediatric Rheumatology is the definitive reference in the field. For physicians caring for children with rheumatic diseases, this revised 8th Edition is an unparalleled resource for the full spectrum of rheumatologic diseases and non-rheumatologic musculoskeletal disorders in children and adolescents. Global leaders in the field provide reliable, evidence-based guidance, highlighted by superb full-color illustrations that facilitate a thorough understanding of the science that underlies rheumatic disease. - Offers expanded coverage of autoinflammatory diseases, plus new chapters on Takayasu Arteritis and Other Vasculitides, Mechanistic Investigation of Pediatric Rheumatic Diseases, Genetics and Pediatric Rheumatic Diseases, and Global Issues in Pediatric Rheumatology. - Reflects the changes in diagnosis, monitoring, and management that recent advances have made possible. - Covers the latest information on small molecule treatment, biologics, biomarkers, epigenetics, biosimilars, and cell-based therapies, helping you choose treatment protocols based on the best scientific evidence available today. - Features exhaustive reviews of the complex symptoms, signs, and lab abnormalities that characterize these clinical disorders. - Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices.

• A comprehensive ophthalmology textbook in two volumes comprising 214 extremely well-researched and well-referenced illustrated chapters spread over 19 sections. • Incorporates recent advances and conceptual challenges along with basic and translational aspects of ophthalmology. • This edition has integrated many contemporary practical ophthalmic healthcare issues, such as accreditation, patient and electronic database safety, health information systems, administration and management, hospital infection control, ethical and medicolegal issues in ophthalmology and clinical aspects of ophthalmic diseases, starting from historical perspectives to current standards of practice. • This book has approximately 4000 high-quality illustrations. • Extensive additions to the section on basic, applied, diagnostic and translational ophthalmology, where applied ophthalmic specialties such as ocular genetics, biochemistry, pathology, microbiology, ophthalmic imaging and applications of artificial intelligence in ophthalmology have been elaborated. • The sections on Pediatric Ophthalmology, oculoplastics, uvea and trauma have been extensively expanded. • Three sections on clinical trials in ophthalmology, ophthalmic healthcare and a completely pictorial atlas comprising pathology, and microbiology slide images and neuroimaging images have been added with detailed descriptions and explanations.

Das Trockene Auge ist eine Volkskrankheit mit deutlich steigender Tendenz, die die Lebensqualität von Patienten mit Trockenem Auge erheblich einschränkt. Es gilt als komplexe Erkrankung, bei der die gesamte Augenoberfläche eine Rolle spielt. Die Behandlung erfordert vom Augenarzt aktuelles Wissen, Geduld und die Erstellung eines individuellen Behandlungsplans. Die 3. Auflage dieses Buches stellt aktuelle pathogenetische Erkenntnisse, diagnostische Möglichkeiten und moderne Therapiestrategien beim Trockenen Auge dar. Dieses Werk bietet sowohl dem erfahrenen Augenarzt als auch ärztlichen Kollegen aus anderen Fachbereichen wertvolle Informationen für die Betreuung ihrer Patienten mit Trockenem Auge.

Sjögren's syndrome is a chronic autoimmune disease which can cause debilitating fatigue and pain. Diagnosis is often challenging due to the variability of symptoms and severity, and a multidisciplinary approach to management and treatment is required, yet there are few comprehensive resources covering everything clinicians need to know. The Oxford Textbook of Sjögren's Syndrome bridges this gap by offering extensive coverage of system by system manifestations and treatments, as well as practical, evidence-based advice on diagnosing and managing this condition. Bringing together recent advances in research and therapies, this up-to-date guide covers everything clinicians need to know from the fundamental science and clinical characteristics of this condition, to the immunological and biochemical aspects, investigative procedures such as biopsy techniques and imaging modalities, and pharmacological and non-pharmacological interventions.

This book provides a thorough update on Sjögren's syndrome (SS) and its adverse impacts on oral health. The opening section focuses on the clinical and laboratory characteristics of SS and its current management. Here, readers will find information on diagnostic criteria, pharmacotherapy, dental management, and the importance of saliva in oral health and SS. Attention then turns to the immunopathogenesis of SS, which includes the mechanisms of secretory dysfunction, myoepithelial cell functions in salivary gland physiology and disease, dysregulated innate and adaptive immunity, and B-cell expansion and neoplasia. The final section details important advances in SS diagnosis and therapy. The differential diagnoses of recurrent glandular swelling, glandular irrigation and sialendoscopy, and salivary gland ultrasound for SS in children are explained, along with the pharmacological management for SS, clinical care for dry eyes, and gene therapy. This book will be of interest to notonly dental practitioners and researchers but also rheumatologists and pathologists.

This thoroughly revised Thirteenth Edition of Burket's Oral Medicine reflects the scope of modern Oral Medicine with updated content written by 80 contributing oral medicine and medical experts from across the globe. The text emphasizes the diagnosis and management of diseases of the mouth and maxillofacial region as well as safe dental management for patients with complex medical disorders such as cardiovascular disease, cancer, infectious diseases, bleeding disorders, renal diseases, and many more. In addition to comprehensively expanded chapters on oral mucosal diseases, including those on ulcers, blisters, red, white and pigmented lesions, readers will also find detailed discussions on: orofacial pain, temporomandibular disorders, headache and salivary gland disease; oral and oropharyngeal cancers, including the management of oral complications of cancer therapy; genetics, laboratory medicine and transplantation medicine; pediatric and geriatric oral medicine; psychiatry and psychology; clinical research; and interpreting the biomedical literature The Thirteenth Edition of Burket's Oral Medicine is an authoritative reference valuable to students, residents, oral medicine specialists, teachers, and researchers as well as dental and medical specialists.

Das Buch vermittelt, mit Herrn Professor Pleyer an der Spitze, umfangreiches Expertenwissen über Pathophysiologie, Diagnostik, Differentialdiagnostik und Therapie entzündlicher Augenerkrankungen. Es ist auf die praktischen Bedürfnisse der in Praxis oder Klinik tätigen Ophthalmologen ausgerichtet und behandelt eine Vielzahl an entzündlichen Augenerkrankungen, die infektiös oder nichtinfektiös, akut oder chronisch sein können. Kompakt und übersichtlich werden pathophysiologische Grundlagen, Leitfäden zur Diagnostik und aktuelle Therapieempfehlungen erläutert. Zahlreiche Flussdiagramme, Praxistipps und farbige Abbildungen machen dieses Buch zu einem diagnostischen und therapeutischen Wegweiser durch das Spektrum der entzündlichen Augenerkrankungen. Für alle Ophthalmologen, aber auch interessierte Internisten, Pädiater und Dermatologen.

Discusses the structure and function of the cornea and external eye and reviews relevant examination techniques. Includes the latest statistics on indications for corneal transplants from the Eye Bank Association of America. Covers infectious and ocular surface diseases; disorders and surgery of the ocular surface; immune-mediated and neoplastic disorders; and congenital anomalies and degenerations. A chapter on the genetics of corneal dystrophies reflects the IC3D classification. Toxic and traumatic injuries and corneal transplantation are also reviewed. Also covers the latest diagnostic imaging technologies, endothelial replacement surgery updates and best practices for sebaceous cell carcinoma early recognition and treatment.

This book is a comprehensive overview of blepharitis that covers the various types of this common and challenging entity.Concise and unique, chapters are clinically focused, providing an equal emphasis on the medical as well as surgical management of this condition. The book concludes with a look atfuture directions in the field as they pertain to diagnosis and management.Blepharitis is an invaluable reference written specifically for comprehensive ophthalmologists, cornea and external disease specialists, residents, fellows, and optometrists.

This book presents the clinical features, invasive and non-invasive modalities of diagnosis of conjunctival and corneal infections, especially atypical clinical situations in unusual cases of keratitis, and manage the disease entity. Infections of cornea continues to be the leading cause of ocular morbidity and blindness worldwide. Early diagnosis helps in better outcome. Proper understanding of the microbiological and clinical characteristics of this disease entity enables ophthalmologists to initiate appropriate therapy. Corneal infections, especially due to uncommon organisms, are difficult to diagnose and treat. With 17 chapters, this volume covers the entire spectrum of corneal and conjunctival infections. This is a quick go-to book for general as well as specialist ophthalmologists.

Written by global experts in the field of chemical- and drug-related ocular problems, Drug-Induced Ocular Side Effects, 8th Edition, provides need-to-know information on all aspects of ocular toxicology in one concise reference. This best-selling, user-friendly resource features a templated format, numerous full-color illustrations, and sweeping content updates throughout – all designed to eliminate uncertainty and ensure accurate diagnosis and treatment guidance. - Provides comprehensive coverage of drugs'generic and trade names, primary uses, ocular and systemic side effects, and clinical significance. - Features a unique side effect index, a new concise paperback format for portability, and clinical photos of ocular symptoms of adverse drug reactions. - Covers dozens of new drugs used in the U.S. and internationally, as well as extensive updates to drug registry information to ensure access to the latest data. - Includes expanded sections on how to follow patients with visual adverse drug reactions to chloroquine, hydroxychloroquine, isotretinoin, ethambutol, and more. Guidelines can be copied to use as patient handouts. - Offers extensive discussions of principles of therapy, ocular drug delivery, methods to evaluate drug-induced visual side effects, and the role of electrophysiology and psychophysics. - Provides the WHO classification system to help you determine whether a particular side effect is certain, probable, or likely to occur. - Ideal for ophthalmologists, optometrists, and busy clinicians in primary care, emergency medicine, and more – anyone who needs quick, on-the-spot consultation on ocular toxicology. - Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices.

Discusses the structure and function of the cornea and external eye and reviews relevant examination techniques. Includes the latest statistics on indications for corneal transplants from the Eye Bank Association of America. Covers infectious and ocular surface diseases; disorders and surgery of the ocular surface; immune-mediated and neoplastic disorders; and congenital anomalies and degenerations. A chapter on the genetics of corneal dystrophies reflects the IC3D classification. Toxic and traumatic injuries and corneal transplantation are also reviewed.

This book provides a concise and up-to-date review of key rheumatology topics along with extensive practice questions to assist in preparing for the American Board of Internal Medicine (ABIM) Rheumatology Certification Exam.Each chapter focuses on a single disease and starts with a short review (primarily tables and figures) to highlight the main points and key issues. The review is followed by 10-20 board-style multiple choice questions with detailed explanations for each topic. The chapters and associated preparation questions are written by established experts from top institutions in the United States. The book concludes with a 50-question practice test reflecting the format used by the ABIM Board Certification Exam.Absolute Rheumatology Review is an essential resource for not only graduate students, residents, and fellows in rheumatology and internal medicine studying for board exams but also rheumatologists, physicians, and related professionals preparing for recertification.

Providing a solid foundation in clinical medicine for optometrists and optometry students, Clinical Medicine for Optometrists covers the systemic medical conditions that have serious impacts on ocular health and function, as well as the ocular exam findings that may be an early indication of significant systemic disease. This unique text explains important medical considerations for optometric practice, meeting the needs of clinical medicine courses in optometry programs, and also serving as a practical reference for optometrists in practice.

Written by leaders in the field and edited by Dr. Frederick Vivino, this concise, practical resource provides best practices for the diagnosis and treatment of Sjogren's Syndrome. It offers a concise overview of this complex autoimmune disease, including information on specific clinical settings, childhood Sjogren's, extra-oral and extra-ocular manifestations, vaccine safety, complementary and alternative medicine, and much more. - Provides concise, clinically focused content with an emphasis on diagnosis and treatment. - Includes Sjogren's Syndrome Foundation Practice Guidelines and the most recent ACR-EULAR classification criteria. - Consolidates today's available information and experience in this important area into one convenient resource.

The field of cornea has seen tremendous advances over the last 40 years—this uniquely comprehensive book will discuss the history of these advances, current best practices in important diseases of the cornea and ocular surface, and examine future directions in diagnosis and management. Written by leading experts, many of whom trained under Claes Henrik Dohlman, MD, PhD, whose influence and many invaluable contributions have defined and shaped the field of cornea, each chapter will reflect the state of the art in the various aspects of cornea. Foundations of Corneal Disease: Past, Present, and Future contains six different sections, opening with an introduction which delves into the evolution of subspecialty training in cornea, and provides a historical perspective of our understanding of ocular surface disease. Section Two addresses perspectives on important corneal and external diseases including infectious keratitis, dry eye, and herpes simplex. SectionThree and Section Four address surgery and surgical alternatives, and frontiers in corneal research. Section Six closes this book with a discussion of special topics: imaging the cornea, corneal blindness, eye banking, and clinical trials in dry eye, and explores future directions in this fast-paced field. Foundations of Corneal Disease: Past, Present, and Future contains is an ideal guide for corneal specialists, ophthalmology residents and fellows planning to enter cornea, corneal scientists, and to those in ophthalmology and visual science interested in a comprehensive resource on cornea and the history of this field.

The title of the book “The Oorja” (Clinical Approach and Management Strategies of Medical Ailments in Women Oorja—The Power of Her) speaks of the empowered women, the women physicians in our club who jointly have made an endeavor to highlight the medical ailments in this gender. A healthy woman is the foundation of a healthy family, a healthy society, a healthy nation, and a healthy universe. Across a volume of 52 chapters, it covers all the major organ systems of a woman's body including cardiology, neurology, endocrinology, gastroenterology, nephrology, rheumatology, psychiatry, ophthalmology, infectious disease, etc. It goes on to discuss the various clinical methods and management strategies of medical ailments in women. The book Clinical Approach and Management Strategies of Medical Ailments in Women is aimed at all medical professionals in general.