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Encyclopedia of Quaternary Science, Third Edition, Six Volume Set brings together the multidisciplinary expertise needed to understand the history of humans, life, environmental, and climate change to understand what we may expect over the coming decades. Since publication of the previous edition, our understanding of many topics has been revolutionized by new discoveries and new techniques. The development of ancient DNA studies, for example, has revolutionized our thinking about the origins, dispersal, and population dynamics of our ancestors. Every new aDNA analysis from ancient human remains causes the story to become more complex.We are the sole survivors of the genus Homo, yet we harbor genetic fragments from other closely related but long-extinct lineages. The Quaternary is uniquely situated as a laboratory in which to study the shaping of the modern world, including biotic responses to large-scale environmental change. This new edition of this book is the most comprehensive account of state-of-the-art research in this field. - Revised and expanded, this new edition brings the science up-to-date by featuring advances in all the multi-disciplinary aspects of Quaternary science - Focuses new content on numerical modeling for paleoclimate and ice-sheet reconstructions, which have greatly advanced since publication of the Second Edition - Covers ancient DNA, which has revolutionized our knowledge of human origins and dispersals, plant and animal population genetics, and more - Includes short, structured chapters, which help readers finding the information they need and save time

With a history that likely dates back to the dawn of human civilization more than 10,000 years ago, and a record that includes the domestication and selective breeding of plants and animals, the harnessing of fermentation process for bread, cheese, and brewage production, and the development of vaccines against infectious diseases, biotechnology has acquired a molecular focus during the 20th century, particularly following the resolution of DNA double helix in 1953, and the publication of DNA cloning protocol in 1973, and transformed our concepts and practices in disease diagnosis, treatment and prevention, pharmaceutical and industrial manufacturing, animal and plant industry, and food processing.While molecular biotechnology offers unlimited opportunities for improving human health and well-being, animal welfare, agricultural innovation and environmental conservation, a dearth of high quality books that have the clarity of laboratory manuals without distractive procedural details and the thoroughness of well-conversed textbooks appears to dampen the enthusiasm of aspiring students. In attempt to fill this glaring gap, Handbook of Molecular Biotechnology includes four sections, with the first three presenting in-depth coverage on DNA, RNA and protein technologies, and the fourth highlighting their utility in biotechnology. Recognizing the importance of logical reasoning and experimental verification over direct observation and simple description in biotechnological research and development, the Introduction provides pertinent discussions on key strategies (i.e., be first, be better, and be different), effective thinking (lateral, parallel, causal, reverse, and random), and experimental execution, which have proven invaluable in helping advance research projects, evaluate and prepare research reports, and enhance other scientific endeavors.Key features Presents state-of-the-art reviews on DNA, RNA and protein technologies and their biotechnological applications Discusses key strategies, effective thinking, and experimental execution for scientific research and development Fills the gap left by detailed-ridden laboratory manuals and insight-lacking standard textbooks Includes expert contributions from international scientists at the forefront of molecular biotechnology research and development Written by international scientists at the forefront of molecular biotechnology research and development, chapters in this volume cover the histories, principles, and applications of individual techniques/technologies, and constitute stand-alone, yet interlinked lectures that strive to educate as well as to entertain. Besides providing an informative textbook for tertiary students in molecular biotechnology and related fields, this volume serves as an indispensable roadmap for novice scientists in their efforts to acquire innovative skills and establish solid track records in molecular biotechnology, and offers a contemporary reference for scholars, educators, and policymakers wishing to keep in touch with recent developments in molecular biotechnology.

Treatise on Geochemistry, Third Edition, 8 volume set is an invaluable resource for geoscientists and others seeking to understand the origin, evolution, and functioning of our inhabited world, in service of a sustainable future.Our need to understand our planet is being reshaped by two ongoing scientific revolutions: the discovery of thousands of exoplanets and the advent of the Anthropocene. These seemingly disparate revolutions challenge us to deepen our understanding of Earth, as our best path to understanding how inhabited planets work. Geochemical knowledge and discovery are at the heart of this challenge, the crossroads where all geoscience subdisciplines meet – much as chemistry is often said to be the'central science', geochemistry is the'central geoscience'. Treatise on Geochemistry fills the gap between mature and established geochemical knowledge, including analytical developments and the rapidly evolving frontiers of the field. - Provides complete and comprehensive coverage of all aspects of the multi-disciplinary field of geochemistry - Restructured to streamline and consolidate topics and draw explicit connections to the twin revolutions of Astrobiology and the Anthropocene in each volume's introductory chapter - Updates to the new edition include new and expanded coverage of emerging topics like cosmochemistry, planetary geochemistry, and exoplanets - Follows a common template, making the work consistent and easier to navigate

Genome Editing for Neurodegenerative Diseases: From Concept to Clinical Trials examines recent advances in neurodegenerative disease research and clinical challenges in practical applications. With an emphasis on genome editing tools such as ZFNs, TALENSs and CRISPR-Cas, this book sheds light on the possibilities to counteract genetic and neurodegenerative diseases. It will be of interest to researchers in neuroscience and biopharmaceuticals, as well as clinicians specializing in neurodegenerative diseases. - Covers basic mechanisms of genome-editing tools and their therapeutic potential - Highlights current research progress and therapeutic strategies to use genome-editing tools against neurodegenerative diseases - Includes research on genome-editing tool development, from basic concept to clinical trials

The second edition of Advances in Bioinformatics presents the latest developments in bioinformatics in gene discovery, genome analysis, genomics, transcriptomics, proteomics, metabolomics, metabolic flux analysis, drug discovery, and drug repurposing. It includes advancements in the applications of bioinformatics in the analysis of non-coding RNA, next-generation sequencing, genome-scale modelling, high throughput drug screening, precision medicine, automation and artificial intelligence, and machine learning. The chapter also summarizes the technologies and concepts that form the basis of this functional genomics approach. Additionally, the book highlights some of the areas in which bioinformatics resources and methods are being developed to support the drug discovery pipeline. The chapter also discusses the role of bioinformatics in modelling and simulations of molecular biology systems in pathways identification and design. It is a valuable source of information for beginners in bioinformatics and students, researchers, scientists, clinicians, practitioners, policymakers, and stakeholders who are interested in harnessing the potential of bioinformatics in biomedical and allied sciences.

This new volume on boron isotope geochemistry offers review chapters summarizing the cosmochemistry, high-temperature and low-temperature geochemistry, and marine chemistry of boron. It also covers theoretical aspects of B isotope fractionation, experiments and atomic modeling, as well as all aspects of boron isotope analyses in geologic materials using the full range of solutions and in-situ methods. The book provides guidance for researchers on the analytical and theoretical aspects, as well as introducing the various scientific applications and research fields in which boron isotopes currently play a major role. The last compendium to summarize the geochemistry of boron and address its isotope geochemistry was published over 20 years ago (Grew &Anovitz, 1996, MSA Review, Vol.33), and there have since been significant advances in analytical techniques, applications and scientific insights into the isotope geochemistry of boron. This volume in the “Advances in Isotope Geochemistry” series provides a valuable source for students and professionals alike, both as an introduction to a new field and as a reference in ongoing research.Chapters 5 and 8 of this book are available open access under a CC BY 4.0 license at link.springer.com

New and innovative scientific theories, discussion and explanations are presented on landform dynamics and evolution in Romania along with a comprehensive understanding of the geomorphological processes shaping the large variety of Romania's landscape. Thematically arranged the book deals with landform dynamics of specific relief types: glacial and periglacial, denudational, fluvio-denudational, fluvial, karst and coasts, as well as sediment fluxes, geomorphic hazards and risks. The authors are key scientists and researchers in the field and offer innovative views on research methods and concepts applied to the topics in question. This work will be of interest to students and researchers in geography, geomorphology, geology, environmental science, paleoclimatology and soil science as well as policy and decision-makers in spatial planning.

This book provides a comprehensive overview of the taxonomy, biology, sedimentation, and carbonate geochemistry of modern species. Students, early career and advanced scientists alike will profit from a broad synthesis of the current understanding of planktic foraminifers as an ecological indicator, biogeochemical factories, and proxies in paleoceanography. The classification of modern species is amply illustrated with electron and light microscope images of morphotypes, addresses the state-of-the-art of molecular genetics of species, and provides a detailed guide for any laboratory analyses. The biology of planktic foraminifers is extensively discussed in chapters dedicated to the cellular ultrastructure, nutrition, symbionts, reproduction, ontogeny, and test architecture. Building on the biological prerequisites, the distribution of planktic foraminifers is discussed at regional to global scale. The geochemistry and sedimentation of tests are considered in relation to the ecology ofthe living animal. In the final chapter, which examines the most common methods in planktic foraminifer research, hands-on information is provided on sampling, processing and analyzing samples in the laboratory, as well as selected established methods for data interpretation. The various topics discussed in this book are aimed at the application of planktic foraminifers as sensitive indicators of the changing climate and marine environment.

This book provides an understanding of the role of human activities in accelerating change in global carbon cycling summarizes current knowledge of the contemporary carbon budget. Starting from the geological history, this volume follows a multidisciplinary approach to analyze the role of human activities in perturbing carbon cycling by quantifying changes in different reservoirs and fluxes of carbon with emphasis on the anthropogenic activities, especially after the industrial revolution. It covers the role of different mitigation options – natural ecological, engineered, and geoengineered processes as well as the emerging field of climate engineering in avoiding dangerous abrupt climate change. Although the targeted audience is the educators, students, researchers and scientific community, the simplified analysis and synthesis of current and up to date scientific literature makes the volume easier to understand and a tool policy makers can use to make an informed policy decisions.

This book summarizes recent advances in understanding the functions of plant and algal lipids in photosynthesis, in development and signaling, and in industrial applications. As readers will discover, biochemistry, enzymology and analytical chemistry, as well as gene knock-out studies have all contributed to our rapidly increasing understanding of the functions of lipids. In the past few decades, distinct physical and biochemical properties of specific lipid classes were revealed in plant and algal lipids and the functional aspects of lipids in modulating critical biological processes have been uncovered. These chapters from international authors across relevant research fields highlight the underlying evolutionary context of lipid function in photosynthetic unicellular and multicellular organisms. The book goes on to encompass what lipids can do for industrial applications at a time of fascination with plants and algae in carbon fixation and as sources for production of food, energy and novel chemicals. The developmental context is a part of the fresh and engaging perspective that is presented in this work which graduate students and scientists will find both illuminating and useful.

Hawaiian Surfing is a history of the traditional sport narrated primarily by native Hawaiians who wrote for the Hawaiian-language newspapers of the 1800s. An introductory section covers traditional surfing, including descriptions of the six Hawaiian surf-riding sports (surfing, bodysurfing, canoe surfing, body boarding, skimming, and river surfing). This is followed by an exhaustive Hawaiian-English dictionary of surfing terms and references from Hawaiian-language publications and a special section of Waikiki place names related to traditional surfing. The information in each of these sections is supported by passages in Hawaiian, followed by English translations. The work concludes with a glossary of English-Hawaiian surfing terms and an index of proper names, place names, and surf spots.

Le yipunu est l'une des langues gabonaises les plus parlées, couvrant la plupart des provinces du pays. Cette méthode est destinée à ceux qui veulent apprendre et acquérir des bases solides en yipunu. Elle donne des éléments de la conversation courante, présente des points de grammaire et un lexique d'environ 3000 mots. L'ouvrage présente également des données sur le fonctionnement de la famille et sur la culture punu.