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Diese Einführung wendet sich an Studierende der Literaturwissenschaft und vermittelt ihnen die zentralen Begriffe, Verfahren und Arbeitstechniken des Fachs. Anhand prägnanter Beispiele werden grundlegende Fragen nach der Bedeutung und historischen Einordnung von Texten geklärt: Was ist ein literarischer Text, und was heißt es, ihn zu lesen, zu verstehen und zu interpretieren? Wie lassen sich Gattungen bestimmen und in ihren Funktionsprinzipien erklären? Was ist ein Autor, und welche Schritte sind notwendig, um ihn und sein Werk einer bestimmten literaturgeschichtlichen Epoche oder literarischen Generation zuzuordnen? Die aktualisierte und erweiterte Neuauflage des bewährten Studienbuches berücksichtigt nicht nur die hohen Anforderungen modularisierter Studiengänge. Es reflektiert auch die Erweiterungen des Faches insbesondere der Themenfelder'Literatur und Medien'und'Literatur und Gesellschaft'. Es geht auf Veränderungen in Bezug auf die Prozesse, die Rezeption und die Partizipation einer beschleunigten digitalen Kommunikation ein, auf Migrations- und Transferprozesse, die den Begriff'(Welt-)Literatur'erweitern und neue Ansätze zur Beschreibung, Deutung und Erklärung von Texten notwendig machen, und auf veränderte gesellschaftliche und identitätspolitische Verhältnisse, die die Schwerpunkte race, class, gender für die literarische Kommunikation prägnant werden lassen. Das Einführungswerk bezieht gattungs- und fiktionalitätstheoretische Reflexionen, Forschungen zu emotionalen Wirkungen poetischer Texte ebenso ein wie konstruktive Überlegungen zu einer kulturwissenschaftlichen und raumtheoretischen Erweiterung der Literaturforschung. Dabei eignet es sich aufgrund seiner philologischen Ausrichtung und weltliterarischen Beispiele nicht nur für Studierende der Germanistik, sondern auch für Einführungskurse in den europäischen Philologien. ••• Ralf Klausnitzer ist unserem Verlag als langjähriger Autor sehr verbunden. Wir sind dankbar, dass wir diese dritte aktualisierte und erweiterte Auflage mit ihm vorbereiten und publizieren durften. Es ist nur eines der Standardwerke, das wir gemeinsam mit ihm gestaltet haben. Seit März 2024 gilt Ralf Klausnitzer als vermisst. Das Team des literaturwissenschaftlichen Programms bei De Gruyter schätzt seine Expertise und sein Engagement und erinnert sich gerne an die Zusammenarbeit. •••

Encyclopedia of Toxicology, Fourth Edition is the most extensive compendium surveying the full scope of toxicology, including its chemical, biological and physical (e.g., radiation) perspectives. Spanning nine volumes, this new edition comprises 1150 thoroughly revised and 70 entirely new entries authored by experts in their respective fields, selected by a globally recognized board who have brought rigorous editorial skills to the project. New areas covered in this release include the bourgeoning field of computational toxicology, research applications of alternatives to animal testing, the rise in development and use of consumer products and their effects on populations, and the increasing introduction and use of pharmaceutical ingredients and their interactions. Other chapters of note cover artificial intelligence models of toxicological exposure and effects, extractables and leachable testing, climate change implications for humans, animals and the environment, screening models, -omics, tools such as sequence alignment to predict across species susceptibility, and much more. - Includes contributions from a world-renowned editorial board and expert contributors with wide-ranging backgrounds in toxicology - Thoroughly updated with the latest advances in the science - Contains concise and accessible content, providing an authoritative reference resource for non-specialists and readers from undergraduate level upwards, as well as advanced healthcare providers - Covers new topics such as computational toxicology, alternatives to animal testing, pharmaceutical ingredients, artificial intelligence models of toxicological exposure and effects, wildfires and effects of their smoke, vaping, high throughput transcriptomics, and the effect of environmental chemicals on the microbiome

This book highlights the role of vitamins in preventing or reducing the pathogenesis or treatment of infectious viral diseases based on current ongoing research and past work. Using clinical evidence and trials that suggest the potential benefits of vitamin supplementation as prophylactic and therapeutic in infectious viral diseases, each individual vitamin is described in this context in separate chapters. It will be a valuable reference aid to researchers, clinicians, and medical bodies to develop improved therapeutic regimens.Key Features: Acts as a one-stop resource on the relevance of vitamins in infectious viral diseases. Provides a clinical focus on disease prevention and therapy using vitamins for clinicians and researchers. Discusses the molecular mechanisms of vitamins in COVID-19 and other viral diseases.

Understand the fundamentals of human risk assessment with this introduction and reference Human risk assessments are a precondition for virtually all industrial action or environmental regulation, all the more essential in a world where chemical and environmental hazards are becoming more abundant. These documents catalog potential environmental, toxicological, ecological, or other harms resulting from a particular hazard, from chemical spills to construction projects to dangerous workplaces. They turn on a number of variables, of which the most significant is the degree of human exposure to the hazardous agent or process. Human and Ecological Risk Assessment combines the virtues of a textbook and reference work to introduce and analyze these vital documents. Beginning with the foundational theory of human health risk assessment, it then supplies case studies and detailed analysis illustrating the practice of producing risk assessment documents. Fully updated and authored by leading authorities in the field, the result is an indispensable work. Readers of the second edition of Human and Ecological Risk Assessment will also find: Over 40 entirely new case studies reflecting the latest in risk assessment practice Detailed discussion of hazards including air emissions, contaminated food and soil, hazardous waste sites, and many more Case studies from multiple countries to reflect diverse international standards Human and Ecological Risk Assessment is ideal for professionals and advanced graduate students in toxicology, industrial hygiene, occupational medicine, environmental science, and all related subjects.

There has been an enormous growth of interest in the field of toxicologic pathology and particularly on its impact on nonclinical safety assessment in global drug development and in the environment. Toxicologic pathologists play an important role in detecting test article-related adverse effects by characterizing morphologic changes in animal tissues and/or body fluids under prescribed study conditions or less clearly defined conditions in the environment and in the interpretation of these findings relative to human risk. In fact, pathology evaluation is often the single most important decision-making factor in nonclinical safety assessments as 80% of drug candidate attrition has been attributed to pathology findings in toxicity studies. There are currently no primers or basic overviews covering the field of toxicologic pathology, whereas there are at least several basic books that cover the sister field of toxicology.Toxicologic Pathology: A Primer is a practical, easy-to-use reference designed to contain core information provided by board-certified veterinary pathologists, all experts in the field. The Primer contains the basic, underlying principles of toxicologic pathology at the introductory level; thus it will be valuable to the veterinary pathology student who may be considering a career in the field as well as a companion to the seasoned toxicologic pathologist who wants a succinct refresher. The Primer is arranged as chapters presenting each major organ system preceded by an overview chapter covering the field of toxicologic pathology followed by a “concept” chapter describing the role of toxicologic pathology in drug development. Photomicrographs and illustrations provide visual context.The organ system chapters provide histopathologic descriptions of lesions observed in toxicity studies of test articles in drug development and testing of chemicals that may negatively impact the environment. Each organ system chapter provides additional information related to a particular lesion to aid the reader in better understanding its toxicologic significance relative to human risk.Each organ system chapter contains: A brief introduction A succinct description of the anatomy and physiology of the system Descriptions of the most important pathological lesions Differential diagnoses Biological consequences, pathogenesis, and/or mechanism of lesion formation Associated clinical pathology correlates Nonclinical safety scientists such as study directors, non-pathology-oriented contributing scientists such as senior toxicology report reviewers, scientific management of Contract Research Organizations (CROs), and students should find the Primer useful in helping them understand the fundamentals of toxicologic pathology.

Die »Enzyklopädie Philosophie- und Wissenschaftstheorie«, das größte allgemeine Nachschlagewerk zur Philosophie im deutschsprachigen Raum, wurde 1980 begonnen und 1996 mit dem vierten Band abgeschlossen. Sie erschien 2005 bis 2018 in einer komplett aktualisierten und erweiterten 8-bändigen Neuauflage, die hiermit nun in einer kartonierten Sonderausgabe vorliegt. Die »Enzyklopädie« umfasst in Sach- und Personenartikeln nicht nur den klassischen Bestand des philosophischen Wissens, sondern auch die neuere Entwicklung der Philosophie, insbesondere in den Bereichen Logik, Erkenntnis- und Wissenschaftstheorie sowie Sprachphilosophie. Zugleich finden Grundlagenreflexionen in den Wissenschaften und deren Geschichte ausführliche Berücksichtigung. Die umfassenden Bibliographien und Werkverzeichnisse wurden für die 2. Auflage in allen Artikeln auf den neuesten Stand gebracht.

This book constitutes the proceedings of the 27th International Symposium on VLSI Design and Test, VDAT 2023. The 32 regular papers and 16 short papers presented in this book are carefully reviewed and selected from 220 submissions. They are organized in topical sections as follows: Low-Power Integrated Circuits and Devices; FPGA-Based Design and Embedded Systems; Memory, Computing, and Processor Design; CAD for VLSI; Emerging Integrated Circuits and Systems; VLSI Testing and Security; and System-Level Design.

While global challenges continue to reshape the here and now, public and corporate finance management needs to adapt quickly to increase the efficiency of institutions, enterprises and policies to face our new reality. There are very few publications that offer a comprehensive approach to the financing of environmental protection activities by the European Union. This book explores this topic from various angles and levels, as well as highlighting the determinants that influence micro- and macro-level decisions in this area.It presents an in-depth and unique analysis of the sources of funding for environmental measures implemented by European Union institutions, against the backdrop of national expenditure by Member States, and analyses the plausibility of the adopted targets in the run-up to 2050, in the context of the war in Ukraine and ad hoc energy policy solutions. This book is a voice in an ongoing discussion among the community of practitioners and theoreticians on sources of financing for the energy transition to achieve independence from Russian sources in the quickest possible timeframe. It demonstrates that environmental measures cannot occur without the financial participation of economic actors and financial institutions, particularly the capital market, and further underscores the scale of involvement in environmental projects, as measured by the value of green loans and green bonds covered by European financial institutions. The authors offer policy recommendations for financing activities related to environmental policy, notably energy transition.This book will appeal to scholars, students and researchers of corporate finance, banking, strategic and public finance management as well as polic-ymakers and practitioners involved in green finance investments.

This book is a collection of peer-reviewed best selected research papers presented at the Fifth International Conference on Advances in Distributed Computing and Machine Learning (ICADCML 2024), organized by the School of Electronics and Engineering, VIT - AP University, Amaravati, Andhra Pradesh, India, during January 5–6, 2024. This book presents recent innovations in the field of scalable distributed systems in addition to cutting-edge research in the field of Internet of Things (IoT) and blockchain in distributed environments.

This textbook deals comprehensively with livestock production diseases and their prevention in the major species: ruminants, swine, and poultry. It gives an interdisciplinary view on pathophysiology, prophylaxis, and health management.Livestock breeding and husbandry is often accompanied by a conflict of interest between the animal´s biological requirements and economic producer needs. This conflict is increasingly gaining attention not only by producers, animal scientists, and veterinarians, but also by the public. It creates significant future challenges, which are described and addressed in this book. The main topics covered are: •the use of antimicrobials with emphasis on security and safety for producers/consumers•the impact of locomotion disorders on performance and welfare of farm animals •the interactions of gut microbiome, genetics, climate change, metabolic status and mineral homeostasis with reproduction, performance, animal health and welfare•infectious and respiratory diseases•the raising of neonatesA special section is devoted to behavioural signs indicating an impaired animal welfare. These are the basis for precision livestock farming (PLF) technology and the development of new management concepts. The present work is a valuable resource for veterinarians, students, as well as expert readers from animal and agricultural sciences, food safety and technology. Supplementary videos can be accessed online as well as directly from the print book; simply download the Springer Nature More Media App for free and scan the links with the play button.

Eine solide Gutachtentätigkeit basiert auf profunder medizinischer Sachkenntnis und neutraler, ausgewogener, wissenschaftlich begründeter Argumentation. Diese umfassende Nachschlagewerk beinhaltet alle Aspekte für die Gutachtenerstellung im HNO-Fachgebiet. Es wendet sich an alle Ärztinnen und Ärzte, die mit der Gutachtertätigkeit beginnen wollen, aber auch an bereits erfahrene Gutachter, die einen Überblick über Literatur, rechtliche Zusammenhänge u.a. suchen. Aus der Praxis: Zahlreiche Beispiele aus der langjährigen Gutachtenpraxis des Autors, Gerichtsurteile, aktuelle Rechtsprechung zum Zitieren, Berücksichtigung der neuesten Leitlinien, Empfehlungen, Verordnungen und Gesetze. Zum Nachschlagen: Formulierungsvorschläge, Querverweise auf Literaturdatenbanken und Originalquellen, Literaturverzeichnis mit DOI und Links zur Einsicht der OriginaltexteFür Zustands- und Zusammenhangsgutachten bis zum umfangreichen freien Gerichtsgutachten mit Sachverständigenanhörung in allen Rechtsgebieten geeignet.

•Designed as an academic project for both postgraduate students and practicing dermatologists. •All sections encompass glimpses of existing knowledge in the light of recent advances. •It will be an expert source of basic knowledge for students in the different forms of dermatoses. •An additional resource for practitioners who needs a clear, concise, and balanced distillation of the best advances information on which to base daily clinical decisions.

This reference book provides a comprehensive overview of models and therapeutic approaches against neurodegenerative diseases, including Parkinson's disease, Alzheimer's disease, Huntington's disease, and amyotrophic lateral sclerosis. It explores models based on the chemical, induced, cellular, genetic, transgenic, and 3D organoid approaches in neurodegenerative diseases. The book also reviews advantages and limitations of these models in designing the treatment strategies. Additionally, the book covers the emerging field of bioinformatics and its application in modeling various neurodegenerative diseases. Towards the end, the book highlights the role of holistic management, precision medicine, OMICS, and gene therapy against neurodegenerative disorders. It examines the implications and significance of stem cells therapy in translational models of neurodegenerative diseases. This book is an invaluable resource for researchers, neuroscientists, and neurosurgeons for getting in-depth information on the neurodegenerative models and therapeutic approaches.Key Features: Provides a comprehensive overview of neurodegenerative diseases and their models Examines the limitations associated with modeling neurodegenerative diseases Presents novel treatment strategies for Alzheimer's disease using cellular models Reviews importance of 3D organoid models for therapeutic approaches in Parkinson's disease Covers modeling techniques in understanding prion diseases Explores the role of genetic models in understanding Huntington's disease

More than 30 years after the collapse of the German Democratic Republic, its cinema continues to attract scholarly attention. Documenting Socialism moves beyond the traditionally analyzed feature film production and places East Germany's documentary cinema at the center of history behind the Iron Curtain. Covering questions of gender, race and sexuality and the complexities of diversity under the political and cultural environments of socialism, the specialist contributions in this volume cohere into an introductory milestone on documentary film production in the GDR.

Established as the definitive reference for the IVF clinic, the sixth edition has been extensively revised, with the addition of several important new contributions on clinical topics, including The use of digitalization and precision medicine in the IVF clinic, The environment and reproduction, The use of gonadotropin-releasing hormone agonists and the efficiency of IVF, Controlled ovarian stimulation for freeze-all cycles, Immunology in ART, Home monitoring of ART cycles, Luteal-phase support in ART, The POSEIDON stratification of ‘low prognosis'patients in ART, Controlled ovarian stimulation for low responder patients, Adjuvants for poor responders, Innovative therapies in diminished ovarian reserve and primary ovarian insufficiency patients, and Fertility options for transgender and nonbinary individuals. As previously, methods, protocols, and techniques of choice are presented by IVF pioneers and eminent international experts.

In the last decades it has become more and more imperative for our societies, and for decision makers in all areas of society, to understand the dynamics through which innovation systems develop and through which socio-technical systems transform themselves. As both innovation and transformation are strongly intertwined, it has equally become imperative to analyse their dynamics as well as their interplay. This open access volume reflects on the research fields that have developed in the last five decades to do exactly that. It defines and delineates research on systems and innovation as encompassing the scientific study of, first, the conditions, dynamics and impacts associated with the generation and uptake of innovations and, second, the development and transformation of functional systems satisfying essential needs such as the provision of energy or water. Further, the area of Systems and Innovation Research (SIR) is characterised by problem and stakeholder oriented research. We chose five decades as time frame because we noted that roughly 50 years ago a number of research institutes dedicated to SIR were founded and the SIR area started to grow significantly. We present a systematic history of nine selected fields within the area of SIR (Innovation policy, Innovation indicators, Foresight, Policy Evaluation, Technology Assessment, Production Paradigms, Renewable Energies, Energy Efficiency, Water Use). We also present a conceptual framework to understand the processes by which the research fields have developed. This allows to draw general lessons as to what drives fields throughout their development and how their role vis-à-vis policy, businesses and societies changes over time. It also allows to speculate about future challenges and trends in the SIR area. This is important because, if anything, the need to govern transformation through innovation will further grow in the future, and with it the need to understand the underlying dynamics.

Encyclopedia of Quaternary Science, Third Edition, Six Volume Set brings together the multidisciplinary expertise needed to understand the history of humans, life, environmental, and climate change to understand what we may expect over the coming decades. Since publication of the previous edition, our understanding of many topics has been revolutionized by new discoveries and new techniques. The development of ancient DNA studies, for example, has revolutionized our thinking about the origins, dispersal, and population dynamics of our ancestors. Every new aDNA analysis from ancient human remains causes the story to become more complex. We are the sole survivors of the genus Homo, yet we harbor genetic fragments from other closely related but long-extinct lineages. The Quaternary is uniquely situated as a laboratory in which to study the shaping of the modern world, including biotic responses to large-scale environmental change. This new edition of this book is the most comprehensive account of state-of-the-art research in this field. - Revised and expanded, this new edition brings the science up-to-date by featuring advances in all the multi-disciplinary aspects of Quaternary science - Focuses new content on numerical modeling for paleoclimate and ice-sheet reconstructions, which have greatly advanced since publication of the Second Edition - Covers ancient DNA, which has revolutionized our knowledge of human origins and dispersals, plant and animal population genetics, and more - Includes short, structured chapters, which help readers finding the information they need and save time

Hayes'Principles and Methods of Toxicology has long been established as a reliable and informative reference for the concepts, methodologies, and assessments integral to toxicology. The new edition contains updated and new chapters with the addition of new authors while maintaining the same high standards that have made this book a benchmark resource in the field. Key Features: The comprehensive yet concise coverage of various aspects of fundamental and applied toxicology makes this book a valuable resource for educators, students, and professionals. Questions provided at the end of each chapter allow readers to test their knowledge and understanding of the material covered. All chapters have been updated and over 60 new authors have been added to reflect the dynamic nature of toxicological sciences New topics in this edition include Safety Assessment of Cosmetics and Personal Care Products, The Importance of the Dose/Rate Response, Novel Approaches and Alternative Models, Epigenetic Toxicology, and an Expanded Glossary. The volume is divided into 4 major sections, addressing fundamental principles of toxicology (Section I.'Principles of Toxicology'), major classes of established chemical hazards (Section II.'Agents'), current methods used for the assessment of various endpoints indicative of chemical toxicity (Section III.'Methods'), as well as toxicology of specific target systems and organs (Section IV.'Organ- and System-Specific Toxicology'). This volume will be a valuable tool for the audience that wishes to broaden their understanding of hazards and mechanisms of toxicity and to stay on top of the emerging methods and concepts of the rapidly advancing field of toxicology and risk assessment.

Engineering Applications in Livestock Production covers the recent advancements and technological developments in the field of livestock production engineering in great detail. The major advances covered in this book include the use of artificial intelligence, image processing, Internet of Things, novel animal product processing technologies, farm automation systems, sensor technology, bioengineering practices and even engineered housing systems among others. - The book includes applications of emerging sensor based and intelligent techniques/systems in the field of livestock production and management - The book will have separate chapters dedicated to innovative approaches in the livestock sector such as artificial intelligence, micro and nano sensors, IoT, image processing and farm automation - Specialists contribution of chapters provide comprehensive details while assisting the understanding of the concepts

Epigenetics is one of the fastest moving fields in drug discovery, with almost every large pharmaceutical company, and a substantial number of biotechnology companies, targeting epigenetic processes to treat diseases ranging from cancer to Huntington's disease and from inflammation to sickle cell anaemia. This book aims to provide an overview of the key topics adopted in current epigenetic drug discovery programmes with a focus on major developments and new technologies. Importantly, the book incorporates case studies and outlines the key challenges and techniques employed to overcome them. The book is an ideal resource for researchers in both industry and academia with an interest in epigenetic and genetic factors involved in drug discovery, target ID and validation. The book is also an excellent introduction for postgraduates interested in the interface between epigenetics and pharmaceuticals.

This volume highlights current research on how the neuroendocrine system helps to influence emotional states and ultimately behavioral output. Social relationships and context-appropriate behavioral responses are important for the survival of most vertebrate species. These relationships can range from transient social interactions to strong social bonding between sexual partners and social behaviors can be observed and evaluated from the individual- to the group-level. Further, behavioral output is shaped by complex interactions between the physical environment, genetics, experience, and context, and are often modulated by the neuroendocrine system. In this book, experts in the field will provide a sweeping look at novel research in the neuroendocrine regulation of important behaviors ranging from parental care to social homeostasis, with a focus on comparative studies across vertebrate species. The first part of the book is dedicated to theneuroendocrinology of relationships, including the coordination of acoustic signals in songbirds, the complexity of social relationships in primates, and cooperation and parenting in humans. The second part of the book focuses on social behaviors and provides some insights into their regulation, including the neuroendocrine regulation of maternal behavior in rodents, the roles of oxytocin and vasopressin in the modulation of sex-specific social behavior, the interactions between adult neurogenesis, the neuroendocrine system and social behavior, and a consideration of neuroendocrine influences on reproductive decision making across species. The book concludes with a section on environmental influences on neuroendocrine systems underlying behavior, including how social isolation and endocrine disrupting chemicals affect the neuroendocrinology of behavior and emotions. Given its breadth, this volume is appropriate for undergraduate students, graduate students, postdoctoral researchers, and established researchers who are interested in neuroendocrinology and behavior. This is the sixteenth volume in the International Neuroendocrine Federation (INF) Masterclass in Neuroendocrinology series, which aims to illustrate the highest standards and highlight the latest technologies in basic and clinical research and aspires to provide inspiration for further exploration into the exciting field of neuroendocrinology.

'Biological Insights of Multi-Omics Technologies in Human Diseases´ provides detailed information about the basics of multi-omic technologies including ethics, historical perspective, science, drug discovery, and development and metabolism. With a strong focus on the practical application of omics approaches in cancer, cardiovascular, neurology, respiratory, viral, gastroenterology, autoimmune diseases, PCOS and tuberculosis, this book also includes special topics related to COVID-19 and Machine learning approaches. In 13 chapters this book provides comprehensive coverage of the challenges and opportunities facing the therapeutic implications of multi-omics from academic, regulatory, pharmaceutical, socio-ethical, and economic perspectives. The chapters are designed in a well-defined chronology such that readers will intuitively understand the central idea. This book is an ideal resource for health professionals, scientists and researchers, nutritionists, health practitioners, students, and all those who wish to broaden their knowledge in the allied field. • Explains the in-depth role of multi-omics on drug discovery/metabolism, diseases, and highlights progress in both the research and clinical areas of computation, as well as relevant implementation experience and challenges. • Describes the practice of multi-omic technologies in the treatment of several diseases.• Includes practical application and machine learning approaches of multi-omics.

Marine Bivalve Mollusks and Emerging Pollutants: Toxicological Impacts provides the most updated and comprehensive knowledge of the toxicological impacts of a variety of emerging pollutants on marine bivalve mollusk species. In addition to synthesizing recent toxicological findings, the book also discusses toxification mechanisms, current challenges, and future research prospects. Written by international experts, this book assesses new advances in the toxicological impacts of pollutants, including microplastics, bromide flame retardants, nanomaterials, pharmaceutical residues, personal care products, pesticides, and perfluorinated compounds. In addition, it details how these can affect reproduction, embryonic development, metabolism, and immune systems of marine bivalves. Behavioral responses and neuroendocrine regulation is also discussed. Toxification mechanisms are interpreted at both physiological and molecular levels. The book concludes with current research and environmental challenges and potentials for further, future study techniques. - Includes the latest findings of pollutant toxicological impacts - Interprets recent understandings of underpinning toxification mechanisms - Identifies limitations and challenges in current studies

The successful book of andrology now in a new edition! This book gives a complete, interdisciplinary overview of the central topics of andrology, infertility, hypogonadism, contraception and erectile dysfunction. It contains detailed information on the clinical practice of couple treatment, andrology-relevant gynecology and modern methods of assisted fertilization, psychological factors of infertility, endocrinology and reproductive functions of the aging man as well as on an important sub-area of ​​andrology, the male contribution to contraception. In addition, the relevant scientific foundations (including molecular biology and genetics) are also covered. Completely revised and updated according to the latest scientific research, the new edition represents a reference for andrology, which no doctor who deals with the topic can miss. For andrologists, practitioners and residents, urologists, dermatologists and internists who deal with the area of​​andrology and male reproductive medicine.

Wie funktioniert eigentlich unser Klima? Warum gibt es immer weniger Trinkwasser? Wie entsteht ein »Müllstrudel«? Wie viel Fläche brauchen wir für unsere Ernährung? Können wir mit innovativer Technik die Welt retten? Antworten auf diese und viele weitere Fragen finden sich in den Grafiken der preisgekrönten Infografikerin Esther Gonstalla. »Das Umweltbuch« zeigt, wie unser Planet funktioniert, und sensibilisiert für seine Vielfältigkeit und Fragilität. Ein Buch für alle, die wissen wollen, wie es um unsere Erde bestellt ist – und welche Ideen und Strategien es gibt, um sie zu retten.

Advances in Remote Sensing for Forest Monitoring An expert overview of remote sensing as applied to forests and other vegetation In Advances in Remote Sensing for Forest Monitoring, a team of distinguished researchers delivers an expansive and insightful discussion of the latest research on remote sensing technologies as they relate to the monitoring of forests, plantations, and other vegetation. The authors also explore the use of unmanned aerial vehicles and drones, as well as multisource and multi-sensor data – such as optical, SAR, LIDAR, and hyperspectral data. The book draws on the latest data and research to show how remote sensing solutions are being used in real-world settings. It offers contributions from researchers and practitioners from a wide variety of backgrounds and geographical regions to provide a diverse and global set of perspectives on the subject. Readers will also find: A thorough introduction to forest monitoring using remote sensing including recent advances in remote sensing technology Comprehensive explorations of sustainable forest management to enhance ecosystem services and livelihood security using a geospatial approach Case studies of monitoring the biochemical and biophysical parameters of forests, including carotene and xanthophyll content Practical advice on how to apply machine learning tools to remote sensing data Perfect for postgraduates, lecturers, and researchers in the fields of environmental science, forestry, and natural resource management, Advances in Remote Sensing for Forest Monitoring will also earn a place in the libraries of professionals and researchers working with remote sensing technology.

This completely updated 4th edition now includes two volumes: it retains the easy-to-use handbook format of the previous successful book, while fulfilling the need for a review of the content. Taking into consideration recent advances in systemic and topical treatments, state-of-the-art lasers, and the latest evidence-based recommendations, it now includes biologic agents for psoriasis and their use as off-label treatments in other skin disorders, targeted agents for malignant melanoma and basal cell carcinoma, and new treatment modalities for rosacea, acne, atopic dermatitis, and urticaria, to name but a few. The European Handbook of Dermatological Treatments provides concise, up-to-date overviews of treatment guidelines and clinical pearls for a large number of skin diseases. It is divided into three main sections addressing the many different skin diseases, the drugs available for dermatological treatments, and the various methods applied in dermatology, including fillers, botulinum toxin, lasers, dermoscopy, cryosurgery, and electrosurgery. Written by a recognized expert in the field, each chapter focuses on a particular skin disease, illustrating current treatments while providing a brief synopsis of the etiology and clinical presentation of the disease. Treatment indications and contraindications, modes of action, and dosages are clearly identified and the content is enhanced by a wealth of clinical pictures and tables, making it an engaging tool for professionals, and a valuable learning resource for young practitioners, as well as postgraduate students and residents.

Das Standardwerk der Andrologie - jetzt komplett aktualisiert! Das Buch gibt einen vollständigen, interdisziplinären Überblick aller Themen der Andrologie, u.a. · der Infertilität, · des Hypogonadismus, · der männlichen Kontrazeption, · der erektilen Dysfunktion und · der Varianten der sexuellen Differenzierung. Der Leser erhält detaillierte Informationen über · die Physiologie der Hoden- und Spermienfunktion · die Diagnostik und Therapie einschl. operativer Verfahren in der Andrologie · die klinische Praxis der Paarbehandlung, · relevante Fakten aus der Gynäkologie, · moderne Verfahren der assistierten Fertilisation · psychologische Faktoren der Sexualität und Infertilität · Umwelteinflüsse auf die Fertilität · Therapie mit Testosteron und Missbrauch · endokrinologische und reproduktive Funktionen des alternden Mannes. · Fertilitätsprotektion · rechtliche und ethische Grundlagen der Andrologie Zusätzlich werden die relevanten naturwissenschaftlichen Grundlagen – einschließlich Molekularbiologie und -genetik – abgedeckt. Komplett nach dem neuesten Stand der wissenschaftlichen Erkenntnis überarbeitet, aktualisiert und praxisorientiert ist der Nieschlag das Standardwerk der Andrologie, an dem keine Ärztin und kein Arzt, der sich mit dem Thema befasst, vorbeikommt. Für Andrologen und Teilnehmer der Zusatzbezeichnung'Andrologie', Urologen, Dermatologen und Internisten, die sich mit dem Gebiet Andrologie beschäftigen. Für Reproduktionsbiologen und Reproduktionsmediziner mit Interesse an der Paarbehandlung.

Nautilus Book Awards Silver RecipientThe award-winning first book for the general public on LADA (Latent Auto-immune Diabetes in Adults), endorsed by a former president of the American Diabetes Association, Kickass Healthy LADA is a fun, empathetic, and practical guide brimming with insights and inspiration. If you are one of the millions of Americans with Latent Autoimmune Diabetes in Adults (LADA), you may not even know it. You may be one of the ten percent of people diagnosed with type 2 diabetes who actually have LADA. Even if you do know that you have LADA, sometimes called “diabetes 1.5,” you're likely to be inundated with unhelpful advice and potentially harmful treatments, leaving you feeling confused and overwhelmed. That was Jacqueline Haskins'experience. After visiting five doctors before getting helpful guidance, and realizing there wasn't a friendly “how-to” book meant for the general public about LADA—she decided to write one. Winner of the 2023 American BookFest Award in Health and a 2023 Reader's Favorite Five-Star selection, Kickass Healthy LADA is a welcoming, supportive book packed with practical strategies and tips that can be tailored to any lifestyle or heritage. This medically vetted go-to guide offers patients and their loved ones relief, hope, and critical information including: A detailed breakdown of the different diabetes diagnoses What makes LADA different and how to find the best treatment team Insulin: what it is, what it does, and how to know if we need more of this natural hormone Tools for good health with LADA, including food and nutrition advice Introducing Carb-Craft: how to safely enjoy the foods you love With a biologist's keen eye, a patient-advocate's tenacity, and the humor of a trusted friend, Jacqueline offers an essential toolkit for anyone diagnosed with LADA.

This book delves into the anthropogenic activities responsible for environmental hazards, their compensation, and potential mitigation strategies. It sheds light on the major contributors to the climate change issues aggravated by non-sustainable practices for the overexploitation of natural resources. Critical topics such as high emissions in primary mining, the recovery of energy-critical metals by urban mining, solid waste management, and forest conservation are explored, offering insights into the urgent challenges we face.Amidst the rapid demand for resources and the expansion of human habitats, the book emphasizes the need for new approaches to natural resource management and introspection of our actions. Experts in the field discuss existing anthropogenic environmental hazards in detail, alongside environmental compensation, and effective mitigation approaches.The book begins with a chapter dedicated to risk assessment in primary mining activities for precious metals, proposing potential routes for mitigation. Chapter 2 focuses on assessing and mitigating the environmental footprints of energy-critical metals used in permanent magnets. In Chapter 3, a case study examines sustainable resource utilization through end-of-life room air conditioner recycling. Additional chapters provide critical insights into:The environmental impacts of e-waste and government policies for responsible managementHazards associated with industrial effluents and corresponding mitigation strategiesThe role of roadside plants in phytoremediation of heavy metal pollutionSustainable utilization of anthropogenic coal fly ash through mechanical and chemical activationEnvironmental damages resulting from the mismanagement of municipal solid wasteEnvironmental problems and remediation strategies for anthropogenic biomass wasteChallenges in sustainable municipal solid waste management and suggestionsfor environmental risk mitigation The book concludes with a chapter discussing collaborative governance and non-monetary compensation mechanisms for sustainable forest management. Given its breadth, this book serves as an indispensable resource for researchers, policymakers, and environmental professionals seeking sustainable approaches to tackle pressing environmental challenges.

Biological sex and gender have a tremendous impact on the efficacy and safety of pharmacological interventions in virtually every disease state. This book presents a comprehensive and up-to-date overview on how sex-specific information is guiding the diagnosis and treatment of diseases affecting men and women, as well as of disease states that disproportionally affects women. Experts in various fields discuss both preclinical and clinical research that is contributing to a better understanding of the impact of sex in the presentation, etiology, treatment, and disease outcomes. Also discussed are the challenges encountered in implementing this growing body of knowledge into practice, as well as possible avenues to recognize and reduce health disparities between men and women so that therapeutic interventions are tailored and improved.

This contributed volume discusses the current status of the occurrences, fate and transport of persistent pollutants in water and wastewater. This contents compile the state-of-the-art of emerging technologies such as nanotechnology, advanced oxidation process, membrane processes, sorption, etc. for the clean-up of persistent pollutants in water including heavy metals, pharmaceuticals, phenolic compounds as well as microplastics and their by-products. This volume will be useful as a guide for the researchers to build strategies to deal with persistent pollutant. It also discusses the principal aspects of degradation mechanism of the pollutants, toxic by-products and effectiveness of the emerging technologies. This volume will be a useful guide for those working in soil and water protection, and environmental civil engineering.

European Glacial Landscapes: The Holocene presents the current state of knowledge on glacial landscapes of Europe and nearby areas over the Holocene to deduce the influence of atmospheric and oceanic currents and the insolation forcing variability and volcanic activity on Holocene paleoclimates, the existence of asynchronies in the timing of occurrence of glacier expansion and shrinkage during the Holocene, time lags between the identification of oceanic and atmospheric changes and those occurring in glacial extension during the Holocene, the role of Holocene glaciers on the climate of Europe, and on sea level variability, and the delimitation of landscapes that need special protection. Students, academics and researchers in Geography, Geology, Environmental Sciences, Physics and Earth Science departments will find this book provides novel findings of all the major European Regions in a single publication, with updated information about Holocene glacial geomorphology and paleo-climatology and clear figures that model the landscapes covered. Provides a synthesis and summary of glacial processes in Europe over the Holocene period Features research from experts in palaeo-climatology, palaeo-oceanography and palaeo-glaciology Includes access to a companion website with an interactive map, photos of glacial features, and geospatial data related to European Glacial Landscapes

Sustainability and Toxicity of Building Materials: Manufacture, Use and Disposal Stages provides a review of toxicity impacts from building materials, including the consideration of the toxicity in the extraction and manufacture of the materials and eventual dismantling and disposal. This book also offers the potential to stimulate future developments in this area, both in terms of knowledge-building and methods for future research. With the increasing emphasis on sustainable construction, it has become important to better understand the impacts of common materials. Civil and structural engineers, postgraduates, researchers as well as architects will find this book to be useful in selecting sustainable building materials.While many building and furnishing materials are safe to use, in recent decades, some have had to be redesigned due to recognition that they contained problem chemicals like formaldehyde. Unfortunately, there is still limited understanding of the toxic impacts of many synthetic chemicals which means that the risks in this area are not well recognized. With increasing interest in using limited resources more sustainably, definitions of what is sustainable should be expanded to move from the focus on energy and carbon impacts to also include more explicit consideration of toxicity impacts. - Examines toxicity in the extraction and manufacturing of materials - Presents the short and long-term toxicity effects of natural and manmade building materials - Guides readers in selecting building materials that have a positive impact on the health of occupants and the environment

This book provides concise but comprehensive and essential information for practitioners and students in the fields of Aesthetic Medicine and Cosmetic Surgery. It not only provides knowledge to the industry, but also defines the new technologies, concludes the traditional therapy and sets up a new consensus for the field. Topics discussed here include the history of the field, energy-based devices, injectables and needle hole procedures, and common cosmetic surgery, among many other subjects.

A holistic approach covering a wide range of environmental microbial applications along with current and future trends In Microbial Biotechnology: Role in Ecological Sustainability and Research, a team of distinguished researchers delivers an authoritative overview of the role of microbial biotechnology in the pursuit of environmental and ecological sustainability. The book provides readers with compelling presentations of microbial technology, including its applications in the removal of environmental pollutants, and sustainable agriculture using microbial biocontrol agents or bio-fertilizers. Readers will also be able to explore the microbial reduction of greenhouse gases and a wide range of other cutting-edge applications, including the removal of various toxic environmental contaminants, such as antibiotics, pesticides, dyes, and heavy metals. Microbial Biotechnology provides: A thorough introduction to microorganisms, their metabolic engineering, the human microbiome, and other foundational topics An in-depth exploration of environmental management, including bioremediation through a nexus approach A fulsome treatment of current trends in microbial biotechnology and its role in sustainable productionPerfect for professionals in applied microbiology, biotechnology, environmental engineering, green chemistry, and soil science, Microbial Biotechnology: Role in Ecological Sustainability and Research will also earn a place in the libraries of research scholars, scientists, and academicians with an interest in environmental microbiology and ecology.

Environmental Contaminants and Endocrine Health focuses specifically on contaminants with hormonal disrupting activities. The book provides insights into the multiple effects of endocrine-disrupting chemicals (EDCs) and their mechanism of action (MoA) on metabolism, reproduction and the multiple physiological roles of the endocannabinoid system which has recently been indicated as new target. The content systematically covers EDC sources and effects, EDCs as sources of disease and health impairment in laboratory models, EDCs as the cause of disease and health impairment in humans and wild species, and the removal of hazardous pollutants from wastewaters to highlight intervention, mitigation and adaptation for reduced threat. This content will be a foundational resource for academic and research staff in endocrinology and hormone toxicology as well as for professors, researchers and students in these areas. - Includes important foundational coverage of the endocrine system, definitions of EDC sources and descriptions, model examples and mechanisms of action biological effects - Provides coverage of EDC effects in humans and animals, from metabolic alterations to epidemiological studies of fertility and metabolism - Presents insights into the confirmed and suspected human diseases spectrum with origins linked to EDC exposure, including cancers, intellectual disabilities, autism, birth defects of the urethra (hypospadias), decreased sperm count, increased rates of miscarriage, obesity, type 2 diabetes, and more

Immer wieder 10 Minuten üben, die Rechtschreibung der 9./10. Klasse sicher im Griff! Um die Rechtschreibung sicher zu beherrschen, ist ständiges Üben und Wiederholen nötig. Der vorliegende Band bietet Ihnen kompakte Einheiten zu allen zentralen Rechtschreibthemen der Klassen 9 und 10. Jedes Arbeitsblatt ist in 10 Minuten lösbar und kann am Anfang der Stunde zur Wiederholung oder zum Aufwärmen, aber auch zur Einführung eines neuen Themas oder als Trainingsmaterial für Zwischendurch eingesetzt werden. Zunächst werden die jeweiligen Rechtschreibregeln von den Schülern selbstständig erarbeitet, dann folgen Arbeitsblätter, die mit kreativen, handlungsorientierten und spielerischen Aufgaben das Thema weiter vertiefen. Jede Kopiervorlage weist zusätzlich eine grafische Kennzeichnung ihres jeweiligen Schwierigkeitsgrades auf. Sowohl für den Regel- als auch den Förderunterricht hervorragend geeignet? damit Rechtschreibung künftig keinen Stolperstein mehr darstellt!

This open access book focuses on of the impact of endocrine disrupting chemicals (EDCs) on human reproduction. It comprehensively discusses the three most important topics in the field: the basic biology of EDCs; the effects of EDCs on human reproduction and human reproductive systems; and potential interventions and practical advice for dealing with the problems caused by EDCs.Presenting a translational approach to endocrine disrupting chemicals research, spanning both basic biology and clinical applications, the book provides a critical link between laboratory investigations and clinical practice. Written by international experts in the field, it is a valuable reference resource for gynaecologists, obstetricians, endocrinologists and experts in reproductive medicine, and a useful tool for anyone interested in the impact of the environment on human reproduction.

This book presents a comprehensive and detailed overview of indoor pollution, covering the main contaminants in the indoor environment – air and dust, the health aspects of exposure, and different possibilities for a risk assessment. The book outlines the chemical substances and physical and biological factors that occur more frequently indoors, which are of health significance, or for which only limited information on their occurrence indoors is available to date. It also provides guidance to identify where problems may arise in the future and where data is missing for a valid exposure and risk assessment as well as for consequent risk management. Written by a highly recognized and experienced medical expert in the field, the book starts with an introduction to the indoor environment, including topics such as indoor environmental quality and health, indoor climate, sampling of indoor pollutants, and measures to improve indoor air quality. The author then delves into the fundamentals of exposure assessment and special exposure indoor situations, followed by in-depth coverage of the health aspects, and indoor air occurrence of several substances such as volatile organic compounds, very volatile organic compounds, semi-volatile organic compounds, and particulate matters and fibers. Particular attention is given to bioaerosols like mold, microbial volatile organic compounds, mycotoxins, and viruses. Readers will also find chapters devoted to the main health aspects and indoor occurrence of inorganic gases, radon and metals, and smoking. The book closes with a chapter on risk assessment, in which readers will learn more about the basics of risk assessment, key points and processes of a health evaluation, and guidance for assessing indoor air contamination. This book is a unique compilation of the current worldwide exposure situation in private and public indoor spaces, and an important reference for researchers that are willing to assess the rising burdenof disease and potential causes behind degraded indoor air quality. Scientists, students, and policymakers interested in the fields of medicine and environmental sciences will understand the appeal of this book.

‘Waste'is generally identified as goods or material that are perceived to be mostly valueless. However, objects that are perceived to be waste based on consumers'object valuation can be redefined to create value. This requires a multitude of efforts using different strategies in waste prevention and management. This book is an edited collection of various chemical approaches used for valorization of solid wastes, particularly, waste electrical and electronic equipment, plastic waste, and agro-residue waste, that provide research insights into the concept'waste-to-energy'. Covering a variety of interdisciplinary topics on waste treatment and resource recovery makes the book one for all that serves as an excellent reading material for engineers, science scholars, entrepreneurs, and organizations who are working in the field of waste management.

Those affected by cancer or receiving cancer treatment have often been more susceptible to infections due to coexisting chronic diseases, overall poor health status, and systemic immunosuppressive states caused by both cancer and anticancer treatments. This pioneering text is an introduction to the key topics in the relationship between infection, pollution, and cancer and is an invaluable resource for residents and junior faculty in Oncology facing the practical problems arising and for those still in training. •Looks at the lessons to be learned for future Oncology patients from a series of studies. •Presents relevant international experience from Oncology clinicians and researchers. •Brings together input from different countries, systems, and specialties.

Impact of Engineered Nanomaterials in Genomics and Epigenomics Overview of current research and technologies in nanomaterial science as applied to omics science at the single cell level Impact of Engineered Nanomaterials in Genomics and Epigenomics is a comprehensive and authoritative compilation of the genetic processes and instructions that specifically direct individual genes to turn on or off, focusing on the developing technologies of engineering nanomaterials and their role in cell engineering which have become important research tools for pharmaceutical, biological, medical, and toxicological studies. Combining state-of-the art information on the impact of engineered nanomaterials in genomics and epigenomics, from a range of internationally recognized investigators from around the world, this edited volume offers unique insights into the current trends and future directions of research in this scientific field. Impact of Engineered Nanomaterials in Genomics and Epigenomics includes detailed information on sample topics such as: Impact of engineered nanomaterials in genomics and epigenomics, including adverse impact on glucose energy metabolism Toxicogenomics, toxicoepigenomics, genotoxicity and epigenotoxicity, and mechanisms of toxicogenomics and toxicoepigenomics Adverse effects of engineered nanomaterials on human environment and metabolomics pathways leading to ecological toxicity Meta-analysis methods to identify genomic toxicity mechanisms of engineered nanomaterials and biological effects of engineered nanomaterial exposure Artificial intelligence and machine learning of single-cell transcriptomics of engineered nanoparticles and trends in plant nano-interaction to mitigate abiotic stresses This comprehensive work is a valuable and excellent source of authoritative and up-to-date information for advanced students and researchers, toxicologists, the drug industry, risk assessors and regulators in academia, industry, and government, as well as for clinical scientists working in hospital and clinical environments.

This book describes how exposure to various classes of endocrine disruptors, as well as other environmental chemicals targeting the endocrine system by alternative non-endocrine mechanisms, impact on endocrinological and endocrinological-related diseases. It includes comprehensive reviews of all aspects of environmental endocrinology, ranging from sources and patterns of exposure and identification of endocrine targets to direct endocrine disruptive mechanisms and indirect actions on the endocrine system, the latter including endocrine cell-directed cytotoxicity, oxidative damage, and genetic and epigenetic aberrations resulting in endocrine damage. It also examines the causal pathways and offers an extensive overview of downstream endocrinological and endocrinological-related disorders. In addition, several chapters focus on transgenerational actions, which are a topic of particular interest. Lastly, evidence from preclinical and clinical studies provides the basis for an in-depth, critical discussion of each topic. The book is part of the SpringerReference program, which provides access to ‘living editions'that are constantly updated using a dynamic peer-review publishing process.

Liquid Chromatography: Applications, Third Edition delivers a single source of authoritative information on all aspects of the practice of modern liquid chromatography. The text gives those working in academia and industry the opportunity to learn, refresh, and deepen their understanding of the field by covering basic and advanced theoretical concepts, recognition mechanisms, conventional and advanced instrumentation, method development, data analysis, and more. This third edition addresses new developments in the field with updated chapters from expert researchers. The book is a valuable reference for research scientists, teachers, university students, industry professionals in research and development, and quality control managers. - Emphasizes the integration of chromatographic methods and sample preparation - Provides important data related to complex matrices, sample preparation, and data handling - Covers the most interesting and valuable applications in different fields, e.g., proteomic, metabolomics, foodomics, pollutants and contaminants, and drug analysis (forensic, toxicological, pharmaceutical, biomedical) - Offers comprehensive updates to all chapters - Adds new chapters on selection of liquid chromatographic mode, proteomics, doping analysis, analysis of microplastics, and analysis of pharmaceutically and biologically relevant isoforms

Der regionale Strukturwandel ist im historischen Kontext vor allem durch den Urbanisierungsprozeß gekennzeichnet. Daneben aber wird er auch geprägt von großräumigen wirtschaftlichen Verschiebungen zwischen Landesteilen mit ähnlichem Verdichtungsgrad. Die regionalökonomische Erklärung solcher Entwicklungsdifferenzen ist gerade heute von großem Interesse, da im Zuge der deutschen Vereinigung oder der Integrationsprozesse in Europa die regionale Wirtschaftspolitik vornehmlich auf eine großräumige Konvergenz der ökonomischen Entwicklung ausgerichtet ist. Der Autor konzentriert sich in diesem Zusammenhang auf die Analyse der Bedeutung des sektoralen Strukturwandels als Erklärungsfaktor für großräumige Wachstumsunterschiede. Der regionale und sektorale Strukturwandel der Beschäftigung wird differenziert nach 5 Großregionen und rund 40 Wirtschaftszweigen auf der Basis der Gewerbe- und Arbeitsstättenzählung von 1895 bis 1987 für das Gebiet der heutigen Bundesrepublik Deutschland dargestellt. Ausgehend von regionalökonomischen Entwicklungstheorien wird ein quantitativer Ansatz zur Bestimmung des Einflusses gesamtwirtschaftlicher Leitsektoren auf die Regionalstrukturen entwickelt. Die Ergebnisse werden vor dem Hintergrund verschiedener Theorieansätze des sektoralen Strukturwandels interpretiert. Die großräumigen Strukturverschiebungen innerhalb Deutschlands sind danach durch Phasen sowohl regionaler Konvergenz als auch räumlicher Konzentration gekennzeichnet. Sie sind eng verbunden mit dem Wechsel gesamtwirtschaftlicher Leitsektoren. Den Regionen kommt dabei jedoch nicht nur eine rein passive Verteilerfunktion zu. Eine zentrale Bedeutung besitzt vielmehr auch die Fähigkeit der Regionen, ihre vielfältigen Ressourcen an die Anforderungen neuer Wirtschaftszweige anzupassen. Regionale Institutionen spielen bei der Schaffung einer solchen Offenheit eine Schlüsselrolle. Gesamtstaatliche Regionalpolitik kann den so erzeugten Anpassungsprozeß lediglich finanziell unterstützen.