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Technology innovation has boomed in the 21st century, and healthcare is no exception. It has revolutionized patient care and treatment. Technological advancements in device development, biotechnology, imaging, and, more recently, machine learning, 3D printing, and artificial intelligence (AI) have transformed healthcare delivery. From disrupting medicine to electronic medical records and now the pivotal role of AI, healthcare delivery has been elevated to unprecedented levels. This book delves into the innovations of the 21st century​​ and provides a comprehensive overview of the latest innovations in medicine, covering a wide range of topics from new diagnostic tools and treatments to the latest advances in medical technology. The book is written in a clear and concise style, making it accessible to readers of various levels of expertise.​​​​ This book provides detailed insights into 21st century healthcare innovations and their prospects. ​It aims to serve as a valuable resource for healthcare professionals, researchers, educators, and anyone interested in the future of medicine. It offers a forward-looking perspective on the transformative innovations shaping healthcare in the 21st century.

This scholarly work discusses the historical, contemporary, and prospective dimensions of environmental activism and its intersection with global media. It provides a comprehensive view of the pivotal role played by the media in shaping awareness concerning environmental challenges and catalyzing actions to address them. Drawing upon the insights of an interdisciplinary cohort of scholars, the book systematically examines the diverse aspects of the nexus between media and environmental activism. Chapter contributions establish the foundational framework for comprehending how media as a whole lend support to activism; delineate the historical trajectory of environmental activism; the construction of narratives within the political, economic, and social domains of society; scrutinize the function of mass media within the context of globalization, digitization, and social media; and elucidate how governance structures influence the environmental activism process. By introducing readers to the basic narrative in environmental activism, globalization, and media, this book will be an important source of information for researchers, academicians and students engaged in various interdisciplinary studies linked to media, environment and activism.

L'Arctique est souvent perçu comme une région isolée du reste du monde, entre autres en raison des conditions difficiles, des populations clairsemées et des infrastructures limitées. D'ailleurs, bon nombre des phénomènes qui affectent et façonnent l'Arctique ont une source extrinsèque à la région, que ce soit le réchauffement climatique, les conflits internationaux ou la mondialisation. Dans cette perspective, cet ouvrage explore les différentes facettes des interactions entre l'Arctique et le reste du système international, regroupé en quatre grandes parties. La première aborde les fondements de la réflexion de cet ouvrage en explorant la place de l'Arctique à l'international et les changements climatiques. La deuxième regroupe les questions liées à la sécurité internationale, telle que la militarisation et les répercussions des guerres. La troisième aborde la gouvernance et les institutions, du point de vue de l'Union européenne, du Conseil de l'Arctique, des nations autochtones et du droit international. Enfin, la dernière partie aborde les secteurs économiques s'intéressant à l'Arctique, que ce soit celui de l'extraction des ressources, des pêcheries, de la navigation ou des communications Web. Cet ouvrage s'adresse d'abord à la communauté universitaire dont les préoccupations de recherche touchent à cette région, mais également à tout lectorat souhaitant faire un bilan des tendances qui concernent et influencent l'Arctique.

Artificial intelligence (AI) has deeply impacted our understanding of creativity and the human ability to generate creative outputs. New applications for creative tasks are rapidly evolving, and new tools are constantly being developed with much greater optimal capabilities. Importantly, the success of implementing such tools for creative tasks is still heavily dependent on human supervision and input. Therefore, it is vital to understand and critically reflect on the nature of co-creative processes between humans and AI. This book addresses such issues and provides insights into how humans can augment their capabilities for generating creative and innovative outputs by successfully co-creating with AI.The book is intentionally divided into three main parts to allow for a comprehensive and holistic perspective on human and AI co-creation for creative tasks. The sections are divided as follows: Part 1: “Principles of AI and Creativity”, Part 2: “Critical Issues on Artificial Co-Creation”, and Part 3: “Industry-Specific Discussions”.Consequently, the book provides a holistic insight on the topic, covering various issues and perspectives and enabling an accessible read to a broad audience. For example, chapters cover examples across different industry sectors, including music, arts, science, and management. Furthermore, the book covers critical questions involving copyrights, ethical concerns, relationship with algorithms, and context-based issues. Only by critically reflecting on the intrinsic issues of AI and learning how to work with it effectively for creative purposes will we be able to benefit from its full potential to augment human creative abilities in an appropriate manner.This novel, edited collection is an essential read for scholars working on the intersection of AI, creativity, arts, and management.

This second edition of the book analyses the latest developments in investment management policy for institutional investors. It is divided into four parts, which have been updated to include the newest approaches and strategies in asset allocation, portfolio management and performance evaluation. The first part analyses the different types of institutional investors, i.e. institutions that professionally manage portfolios of financial and real assets on behalf of a wide range of individuals. This part goes on with an in-depth analysis of the economic, technical and regulatory characteristics of the various categories of investment funds and of other types of asset management products, which have a high rate of substitutability with investment funds and represent their natural competitors. The second part of the book identifies and investigates the stages of the investment portfolio management. Given the importance of strategic asset allocation in explaining the ex post performance of any type of investment portfolio, this part provides an in-depth analysis of asset allocation methods, illustrating the different theoretical and operational solutions available to institutional investors. The third part describes performance assessment, its breakdown and risk control, with an in-depth examination of performance evaluation techniques, returns-based style analysis approaches and performance attribution models. Finally, the fourth part deals with the subject of diversification into alternative asset classes, identifying the common characteristics and their possible role within the framework of investment management policy. This part analyses hedge funds, private equity, private debt, real estate, infrastructures, commodities and currency overlay techniques.

In A Research Agenda for Arctic Tourism, experts address key topics related to tourism in the North such as the climate crisis, increased political and economic turmoil, and the complexity of interests and relations among stakeholders. Suggesting potential pathways for research on Arctic tourism, the contributors recognize tourism as one future storyline for the Arctic: a storyline embedded in local human and non-human communities.Bringing in-depth and innovative scholarship together with creative thinking across tourism disciplines, this Research Agenda examines both the positive and negative effects of tourism development in the Arctic: from emerging new transport infrastructure and business, employment and economic opportunities to the impact on indigenous and local communities as well as nature. Experts in Northern tourism explore traditional business perspectives in tourism research with alternative theoretical approaches, highlighting communities and spatial relations. Scholars researching tourism management and tourism from social science perspectives, as well as Arctic studies more broadly, will appreciate the insights highlighted and the links to the wider topics of international relations, politics, sociology, geography and anthropology.

In recent decades, bio-nano interfaces have become a popular topic of research. The interface between biology (e.g., cells, proteins) and man-made materials (e.g., surfaces of labware, medical devices/implants, etc., that are exposed to the biological matter) has always been important, way before the terms of nanotechnology and nanoscience were coined. Nanotechnology brought new techniques into play, with which such interfaces can be investigated with an additional viewpoint. This book is a collection of articles spanning two decades that shows how the newer publications have evolved from the older ones. This allows the reader to see the development in the field not only technically but also conceptually. The book is, in particular, suitable for the researchers and general readers who are looking for inspiration on how ideas develop over decades.

Genodermatoses are often considered rare diseases seldom seen by practicing clinicians, but as a result, professionals often have little experience or confidence with their diagnosis when they are called upon for a clinical case.This text presents a comprehensive illustrated overview of almost 200 inherited diseases of the skin, hair, and nails. Examples have been expanded, with new images added to provide clear examples, alongside coherent and comprehensive explanations to enable clinicians to easily identify and source relevant information. This resource encompasses a varied range of skin diseases, providing accessible and in-depth information to help familiarise clinicians. The entry for each disease provides background, followed by common characterisations, manifestations, laboratory findings, genetics, cutaneous and extracutaneous findings, differential diagnosis, an overview of complications and recommended follow-ups.Authored by dermatologists and geneticists, this is an atlas of scientific research which updates established information with current studies and references. In its third edition, this text becomes an invaluable resource for dermatologists and pediatricians.

This book gathers outstanding papers presented at the International Conference on Data Science and Applications (ICDSA 2023), organized by Soft Computing Research Society (SCRS) and Malaviya National Institute of Technology Jaipur, India, from 14 to 15 July 2023. The book is divided into four volumes, and it covers theoretical and empirical developments in various areas of big data analytics, big data technologies, decision tree learning, wireless communication, wireless sensor networking, bioinformatics and systems, artificial neural networks, deep learning, genetic algorithms, data mining, fuzzy logic, optimization algorithms, image processing, computational intelligence in civil engineering, and creative computing.

Das Buch beschreibt die Grundlagen der Femtosekundenlaser, d.h. Strahlungsquellen mit ganz neuen Möglichkeiten in Technik, Chemie, Produktion und Medizin. Neben etablierten Verfahrenstechniken kommen modernste Einsatzgebiete des Zeitmikroskops, das zur direkten Beobachtung von Elektronen dient, zur Sprache. In der Chemie und Biologie geschehen optische Übergänge durch optische Anregung auf ganz bestimmten Zeitskalen, und der Femtosekundenlaser kann dabei helfen, die schnellsten Zeitbereiche dieser untersuchten Übergänge präzise aufzulösen. Neben den neuartigen Gebieten Femtochemie, Femtonik und Attowissenschaften werden spezielle Anwendungen an der Grenze von Forschung und Theorie erläutert. 1999 gab es den Nobelpreis für Ahmed Zewail für seine Erfolge um das Gebiet der Femtochemie. Am 20. Dezember 2013 hat die UN-Generalversammlung das Jahr 2015 als „Internationales Jahr des Lichts und der lichtbasierten Technologien“ ausgerufen. Das Jahr des Lichts „soll an die Bedeutung von Licht als elementare Lebensvoraussetzung für Menschen, Tiere und Pflanzen und daher auch als zentraler Bestandteil von Wissenschaft und Kultur erinnern“. Heute gilt die Femtosekundentechnologie als der Innovations- und Wirtschaftsmotor der Zukunft und wird viele Arbeitsplätze in der Industrie sichern helfen. Neben der Zahn- und Krebsmedizin sowie Augenheilkunde ist der Femtosekundenlaser auch bei industriellen Anwendungen nicht mehr wegzudenken. Man kann Werkstoffstrukturen im Nanometerbereich mit einem Ti:Saphir-Femtosekundenlaser herstellen. Ein Ausblick auf das nächste Technik-Zeitalter – das des Lichts – wird mit einem abschließenden kleinen Lexikonteil und Literaturzitaten gegeben.

Treatise on Geochemistry, Third Edition, 8 volume set is an invaluable resource for geoscientists and others seeking to understand the origin, evolution, and functioning of our inhabited world, in service of a sustainable future.Our need to understand our planet is being reshaped by two ongoing scientific revolutions: the discovery of thousands of exoplanets and the advent of the Anthropocene. These seemingly disparate revolutions challenge us to deepen our understanding of Earth, as our best path to understanding how inhabited planets work. Geochemical knowledge and discovery are at the heart of this challenge, the crossroads where all geoscience subdisciplines meet – much as chemistry is often said to be the'central science', geochemistry is the'central geoscience'. Treatise on Geochemistry fills the gap between mature and established geochemical knowledge, including analytical developments and the rapidly evolving frontiers of the field. - Provides complete and comprehensive coverage of all aspects of the multi-disciplinary field of geochemistry - Restructured to streamline and consolidate topics and draw explicit connections to the twin revolutions of Astrobiology and the Anthropocene in each volume's introductory chapter - Updates to the new edition include new and expanded coverage of emerging topics like cosmochemistry, planetary geochemistry, and exoplanets - Follows a common template, making the work consistent and easier to navigate

This book introduces a groundbreaking approach to enhancing IoT device security, providing a comprehensive overview of its applications and methodologies. Covering a wide array of topics, from crime prediction to cyberbullying detection, from facial recognition to analyzing email spam, it addresses diverse challenges in contemporary society. Aimed at researchers, practitioners, and policymakers, this book equips readers with practical tools to tackle real-world issues using advanced machine learning algorithms. Whether you're a data scientist, law enforcement officer, or urban planner, this book is a valuable resource for implementing predictive models and enhancing public safety measures. It is a comprehensive guide for implementing machine learning solutions across various domains, ensuring optimal performance and reliability. Whether you're delving into IoT security or exploring the potential of AI in urban landscapes, this book provides invaluable insights and tools to navigate the evolving landscape of technology and data science. The book provides a comprehensive overview of the challenges and solutions in contemporary cybersecurity. Through case studies and practical examples, readers gain a deeper understanding of the security concerns surrounding IoT devices and learn how to mitigate risks effectively. The book's interdisciplinary approach caters to a diverse audience, including academics, industry professionals, and government officials, who seek to address the growing cybersecurity threats in IoT environments. Key uses of this book include implementing robust security measures for IoT devices, conducting research on machine learning algorithms for attack detection, and developing policies to enhance cybersecurity in IoT ecosystems. By leveraging advanced machine learning techniques, readers can effectively detect and mitigate cyber threats, ensuring the integrity and reliability of IoT systems. Overall, this book is a valuable resource for anyone involved in designing, implementing, or regulating IoT devices and systems.

This Open Access book describes how the aging populations of high-income countries and younger, more vulnerable populations living in low-to-middle income countries are increasingly affected by cardiac events (including hospitalisation and premature mortality) that do not occur randomly. Instead, they rise and fall in response to climatic conditions. This relationship represents a complex bio-behavioral interaction between individuals at risk of experiencing an acute cardiovascular event and their environment. Unfortunately, expert guidelines and epidemiological reports ignore this fundamental fact – cardiac events in nearly every country fluctuate with predictable climatic transitions (seasons) and random external provocations (including noise and air pollution plus unseasonal cold snaps and heat waves). Climate change, in the form of more unpredictable weather (including more sustained heat waves) will only exacerbate the problem, especially among the world's poorest people. Heart Disease and Climate Change articulates why this phenomenon occurs, how climate change is likely to exacerbate the problem (thereby harming economies/stifling Development Goals) and what we need to do to mitigate the impact of climate change on heart health. It identifies key areas for future research/reporting of cardiac events and hence is an essential reference for all interested in the management of patients in cardiovascular medicine, from cardiologists, internists and primary care physicians to healthcare administrators, climate researchers and politicians.

In this international bestseller investigating the murder of the Russian Imperial Family, Helen Rappaport embarks on a quest to uncover the various plots and plans to save them, why they failed, and who was responsible.The murder of the Romanov family in July 1918 horrified the world, and its aftershocks still reverberate today. In Putin's autocratic Russia, the Revolution itself is considered a crime, and its anniversary was largely ignored. In stark contrast, the centenary of the massacre of the Imperial Family was commemorated in 2018 by a huge ceremony attended by the Patriarch of the Russian Orthodox Church.While the murders themselves have received major attention, what has never been investigated in detail are the various plots and plans behind the scenes to save the family—on the part of their royal relatives, other governments, and Russian monarchists loyal to the Tsar. Rappaport refutes the claim that the fault lies entirely with King George V, as has been the traditional view for the last century. The responsibility for failing the Romanovs must be equally shared. The question of asylum for the Tsar and his family was an extremely complicated issue that presented enormous political, logistical and geographical challenges at a time when Europe was still at war. Like a modern day detective, Helen Rappaport draws on new and never-before-seen sources from archives in the US, Russia, Spain and the UK, creating a powerful account of near misses and close calls with a heartbreaking conclusion. With its up-to-the-minute research, The Race to Save the Romanovs is sure to replace outdated classics as the final word on the fate of the Romanovs.

This book explores the global technological transformations that have shaped development of society for eons, from the emergence of Homo sapiens to the modern day. Looking at a potential future for all of this century and the beginning of the next, the book explores how society is changing as a result of the two most powerful trends: technological advances and global aging. It studies the forthcoming technological wave – the Cybernetic Revolution, which will encompass AI, medical technology and biotechnology, robotics, cognitive, nanotechnology etc. In turn, it shows why and how global aging will become one of the most powerful factors, influencing the evolution of society and the World System as a whole. Lastly, the book demonstrates how technological innovations can change the way people live and the society of the future, assessing both the new opportunities and threats posed by uncontrolled technological progress. Accordingly, it will appeal to social scientists, political scientists, economists and historians who are interested in technological transformations and their social and economic impacts.

Parasitology, the study of parasites and their relationships to their hosts, is one of the most fascinating areas of the biology. Parasitology has traditionally been limited to parasitic Protozoa, Platyhelminthes, and Nemathelminthes, as well as those species of organisms that serve as vectors for parasites. But now a day it is approaching to all groups of Parasites including unicellular to multicellular organisms with special reference to taxonomy, classical morphology, ultra topography, bioecology, epidemiology, molecular heterogeneity, phylogeny, biochemistry, and in silico genome analysis to resolves it ambiguity in identification to biodiversity, biotechnology, and clinical diagnosis and health consequences. “Parasitology: Risks and Challenges for Health and Sustainability” emphasizes how parasites influence, and are influenced by, a complex web of interacting factors. The book has been divided into eight conventional chapters that cover all the aspects of Parasitology to show how topics are inter-related. The reader will find certain subjects are picked up, put down, discussed in more detail elsewhere, and then returned to in a later chapter.

Volumes 45a and 45b of Advances in Econometrics honor Professor Joon Y. Park, who has made numerous and substantive contributions to the field of econometrics over a career spanning four decades since the 1980s and counting. This second volume, Essays in Honor of Joon Y. Park: Econometric Methodology in Empirical Applications, focuses on econometric applications related, some closely and some very loosely, to Professor Park's more recent work before concluding with a retrospective summarizing four decades of Advances in Econometrics.

This volume of the International Symposia in Economic Theory and Econometrics explores the latest economic and financial developments in Africa and Asia. Chapters cover a range of topics such as: the relationship between good stewardship, agency costs, and performance of South African firms; stock market dynamics in Thailand, including risk & mutual fund clustering and zero-investment portfolios strategies; and a special focus on financial markets in Indonesia such as fundamental indexing with Markowitz mean variance portfolios, a financial performance analysis of highway companies before and during the Covid-19 pandemic, and a credit risk scoring model for consumer financing. Comparative Analysis of Trade and Finance in Emerging Economies also addresses the issue of whether the West African Monetary Zone can form a Currency Union, and, examines the impact of non-tariff measures of China on the export of agricultural products of Laos. These peer-reviewed papers touch on a variety of timely, interdisciplinary subjects such as stock markets and the effects of public policy. Together, ISETE 31, is a crucial resource of current, cutting-edge research for any scholar of international finance and economics.

This book contains an Open Access chapter. Volume 41 of Research in Personnel and Human Resources Management offers several original scholarly contributions written by thought leaders in the field of human resources management. These chapters feature the latest research exploring emerging novel areas of HRM. Contributions include an analysis of professional touching behaviour, ideas about the state of our science in HRM, an Open Access chapter on work-life flexibility issues, processes that occur in expatriate turnover, suggestions concerning the state of human resource process research, and some comments on the contribution of this series to facilitating research in HRM issues

This book takes readers to Antarctica, the Arctic and the high mountains, to see what is happening to their ice, snow and permafrost. Ice and snow reflect solar energy back to space, keeping the planet cool. As global overheating melts them away, we are losing this refrigeration factor, which adds to global overheating. The author begins by laying out the evidence for carbon dioxide as the control knob of climate, and hence of sea level, for the past 1000 million years, before exploring the effects of climate change in the three main icy regions. He shows us how climate change will likely affect us and the planet as we approach the end of this century and beyond. His story ends by analysing how politics and economics are determining our response to global overheating, reminding readers of the enormous global challenges inherent in changing from a fossil fuel to a renewable energy infrastructure. There is no overnight solution. Can we save Earth's refrigerator? Will Net Zero work? Addressing these key questions Summerhayes is cautiously optimistic about our chances provided we have the collective will to act on what we know.

This open access handbook describes foundational issues, methodological approaches and examples on how to analyse and model data using Computational Social Science (CSS) for policy support. Up to now, CSS studies have mostly developed on a small, proof-of concept, scale that prevented from unleashing its potential to provide systematic impact to the policy cycle, as well as from improving the understanding of societal problems to the definition, assessment, evaluation, and monitoring of policies. The aim of this handbook is to fill this gap by exploring ways to analyse and model data for policy support, and to advocate the adoption of CSS solutions for policy by raising awareness of existing implementations of CSS in policy-relevant fields. To this end, the book explores applications of computational methods and approaches like big data, machine learning, statistical learning, sentiment analysis, text mining, systems modelling, and network analysis to different problems in the social sciences. The book is structured into three Parts: the first chapters on foundational issues open with an exposition and description of key policymaking areas where CSS can provide insights and information. In detail, the chapters cover public policy, governance, data justice and other ethical issues. Part two consists of chapters on methodological aspects dealing with issues such as the modelling of complexity, natural language processing, validity and lack of data, and innovation in official statistics. Finally, Part three describes the application of computational methods, challenges and opportunities in various social science areas, including economics, sociology, demography, migration, climate change, epidemiology, geography, and disaster management. The target audience of the book spans from the scientific community engaged in CSS research to policymakers interested in evidence-informed policy interventions, but also includes private companies holdingdata that can be used to study social sciences and are interested in achieving a policy impact.

This book is devoted to a systemic study of socio-economic development risks arising in the Decade of Action, as well as the prospects for risk management in support of sustainable development. It aims to overcome fragmentary consideration of risks in the existing literature through their comprehensive coverage and the establishment of their interconnections from the perspective of sustainable development.The novelty of this book is that it provides a comprehensive accounting of socio-economic development risks in the Decade of Action, as well as a rethinking of these risks from a sustainable development perspective. The book also opens up the possibility of the most comprehensive and effective risk management in support of sustainable development. The practical relevance of the book stems from the fact that it describes and discusses practical experience in detail and accompanies the theoretical material with numerous case studies, including cases and frameworks with extensive coverage of international best practices.The book is intended for scholars, for whom the book forms a systemic scientific view of the risks of socio-economic development arising in the Decade of Action, as well as the prospects for risk management in support of sustainable development. The book is also of interest to practitioners, for whom it offers practical advice on risk management at all levels of the economy for sustainable development. Many examples from different countries make the book attractive to a wide international audience. The book is of particular interest to readers from Russia.

Este libro no es un simple manual, ni un tratado de violín al uso. Yuri Yankelévitch compartió en sus escritos una buena parte de su enorme y valioso conocimiento empírico sobre la formación violinística y musical. Aborda numerosas e importantes cuestiones técnicas, pero sin olvidar jamás su finalidad última: hacer música. Es por ello que se trata de un libro de gran interés para cualquier tipo de instrumentista y especialmente para los docentes que forman a los músicos del mañana. La obra está dividida en dos partes. La primera, con los escritos de Yankelévich, basados en el estudio de numerosos tratados de violín y su propia experiencia docente. Textos nutridos de información detallada, extremadamente valiosos para resolver algunos de los problemas más fundamentales de la docencia violinística. La segunda parte del libro aborda: el examen, estudio y relato sobre la metodología y el acercamiento a la práctica docente de Yuri Yankelévich relatado por algunos de sus compañeros de profesión, amigos cercanos, asistentes y alumnos. El libro de Yuri Yankelévich es ampliamente conocido desde hace varias décadas en todo el mundo y ha sido citado en numerosos trabajos y estudios.

Die Anwendungen der Disziplin Data Science erweitern und wandeln sich stetig. In diesem Buch geben Insider aus Praxis, Wissenschaft und Lehre detailliert die Ergebnisse ihrer Data-Science-Projekte, Methodenwissen sowie Knowhow zu Vorgehensweisen und Prozessmodellen an den Leser weiter. Dabei wird ein weit gespannter Querschnitt an konkreten Anwendungen beschrieben, erklärt und illustriert: von der Nutzung generativer KI-Systeme über quantitative Textanalyse, Predictive Policing, Erklärbarkeit von Machine-Learning-Modellen, experimentelle Datenanalyse in der Spektroskopie bis hin zu Datenvisualisierung, Strukturgleichungsmodellen und Varianzanalyse.Das Buch richtet sich an jeden, der sowohl am konkreten Einsatz von Datenwissenschaft, Statistik, Maschinellem Lernen und Künstlicher Intelligenz als auch am zugehörigen theoretischen Hintergrund interessiert ist. Praktikern, Studierenden und Lehrenden dürfte es von besonderem Nutzen sein: eine Vielzahl an Abbildungen, Diagrammen und Illustrationen ergänzen die reichhaltigen Textinformationen; Links zu Webseiten und Webapplikationen verweisen auf online verfügbare weitere Informationsquellen und Data-Science-Werkzeuge.

This book has two main objectives: • to provide a concise introduction to nonlinear optimization methods, which can be used as a textbook at a graduate or upper undergraduate level; • to collect and organize selected important topics on optimization algorithms, not easily found in textbooks, which can provide material for advanced courses or can serve as a reference text for self-study and research. The basic material on unconstrained and constrained optimization is organized into two blocks of chapters: • basic theory and optimality conditions • unconstrained and constrained algorithms. These topics are treated in short chapters that contain the most important results in theory and algorithms, in a way that, in the authors'experience, is suitable for introductory courses. A third block of chapters addresses methods that are of increasing interest for solving difficult optimization problems. Difficulty can be typically due to the high nonlinearity of the objective function, ill-conditioning of the Hessian matrix, lack of information on first-order derivatives, the need to solve large-scale problems. In the book various key subjects are addressed, including: exact penalty functions and exact augmented Lagrangian functions, non monotone methods, decomposition algorithms, derivative free methods for nonlinear equations and optimization problems. The appendices at the end of the book offer a review of the essential mathematical background, including an introduction to convex analysis that can make part of an introductory course.

This third of three related volumes is structured in 3 sections and 46 chapters covering every aspect of Hair Restoration Surgery (HRS), alternative and future treatments for AGA/FPHL, as well as hair loss concealment and hair care. The reader will find dedicated chapters on every aspect of HRS: from the initial,'prehistoric'HRS techniques that have cosmetically stigmatized countless patients and defamed the field to in-depth coverage of all modern HRS techniques endorsing a'cosmetic revolution'. Modern HRS techniques that offer results indistinguishable from natural hair in male and female patients are described in detail, with invaluable surgical pearls and strategies on how to treat complications, repair substandard results and even how to build a successful HRS practice. Chapters include more than a thousand original and unique full-color photos of unique cases, figures, tables, and invaluable surgical tips. The safety and applicability of Low Level Laser Therapy, Genetic Engineering/Gene Therapy, Stem Cell Therapy, Hair Follicle Cloning, Platelet Rich Plasma, Scalp Microneedling and Exosomes on AGA/FPHL are thoroughly reviewed in dedicated chapters, validated by several updated and balanced literature citations. All types of cover-up products that can'camouflage'baldness are reviewed in detail through the author's vast experience in their clinical use. An elaborate chapter on hair prosthesis and wigs illustrates how patients with extensive AGA can have a natural appearance and unrestricted life. The psychological entrapment, social awkwardness, hidden costs, and downsides of the wig industry are assessed. Finally, details on hair hygiene and how they can drastically affect hair loss are offered in a separate chapter. Handy, thorough, and practical, Androgenetic Alopecia From A to Z, Hair Restoration Surgery and Alternative Treatments Volume 3 will meet the needs of dermatologists, plastic surgeons, general practitioners, and all other physicians involved in this fast growing and fascinating field.

This book collects the proceedings of a series of conferences dedicated to birational geometry of Fano varieties held in Moscow, Shanghai and PohangThe conferences were focused on the following two related problems:• existence of Kähler–Einstein metrics on Fano varieties• degenerations of Fano varietieson which two famous conjectures were recently proved. The first is the famous Borisov–Alexeev–Borisov Conjecture on the boundedness of Fano varieties, proved by Caucher Birkar (for which he was awarded the Fields medal in 2018), and the second one is the (arguably even more famous) Tian–Yau–Donaldson Conjecture on the existence of Kähler–Einstein metrics on (smooth) Fano varieties and K-stability, which was proved by Xiuxiong Chen, Sir Simon Donaldson and Song Sun. The solutions for these longstanding conjectures have opened new directions in birational and Kähler geometries. These research directions generated new interesting mathematical problems, attracting the attention of mathematicians worldwide.These conferences brought together top researchers in both fields (birational geometry and complex geometry) to solve some of these problems and understand the relations between them. The result of this activity is collected in this book, which contains contributions by sixty nine mathematicians, who contributed forty three research and survey papers to this volume. Many of them were participants of the Moscow–Shanghai–Pohang conferences, while the others helped to expand the research breadth of the volume—the diversity of their contributions reflects the vitality of modern Algebraic Geometry.

Resident Stem Cells and Regenerative Therapy: Sources and Clinical Applications, Second Edition presents the main findings to date and the important factors to be considered when contemplating resident stem cells in regenerative therapies. Chapters on cardiac, brain, neural, liver, kidney, skeletal muscle, bone, pancreatic, skin and lung resident stem cells will assist in defining the level of success that has been achieved and the direction for the road ahead. With contributions from leading laboratories, open questions related to resident stem cells and regenerative therapies will also be presented for debate. In the last several decades, stem cells have greatly impacted the scientific and lay communities, providing huge advances in the treatment of devastating human diseases, including myocardial infarction, diabetes, muscular dystrophy, cystic fibrosis, cirrhosis, and osteoporosis. Alongside debates of induced pluripotent stem cells and embryonic stem cells has been the discovery of adult stem cells in many different tissues. While these organ resident or progenitor stem cells offer prospects to contribute to tissue regeneration, they also present challenges because of the complexity of organ structures. - Highlights basic research in tissue specific stem cells, experiments with animal models, and clinical trials that are transforming the field of regeneration - Provides a clear understanding of endogenous stem cells, their role in current regenerative therapies, and prospects for future research - Reports on the main-stream clinical approaches and in vivo experiments published in primary literature to help categorizes the advances in various aspects of regenerative therapy and illustrate opportunities for clinical applications

Lord Eli Ev needs to cooperate with a demon from a hostile world, Ayavazashi, to find who targets him. Politicking and betraying themselves four lords of Uwa uncover their dirty secrets. Then they realise that the greatest evil lurks just nearby and they have created it.

With the unique chemical and physical properties of cold atmospheric plasmas enabling its recent applications in biomedicine, plasma medicine has established itself as a new scientific field, combining plasma physics, engineering, medicine, and bioengineering. This book provides a comprehensive introduction to the fundamentals of the non-thermal plasmas and plasma devices used in plasma medicine. Several chapters are devoted to the analysis of the mechanisms of plasma interaction with cancer and normal cells, including a description of the mechanism of plasma selectivity. As a revised and significantly expanded second edition, this text includes a detailed description of non-invasive modality, new in vivo work and adaptive plasma written by experts in these areas. This reference text also provides an up-to-date description of the field, the primary challenges and future directions. Key Features Provides an up-to-date description of the fast-growing field of plasma-based cancer therapy Provides a comprehensive introduction to the fundamentals of non-thermal plasmas and plasma devices used in plasma medicine New edition is updated to include a detailed description of non-invasive modality, new in vivo work and adaptive plasma written by experts in these areas Discusses the primary challenges and future directions of the field

This book is a collection of extremely well-articulated, insightful and unique state-ofthe-art papers presented at the Computing Conference which took place in London on June 22–23, 2023. A total of 539 papers were received out of which 193 were selected for presenting after double-blind peer-review. The book covers a wide range of scientific topics including IoT, Artificial Intelligence, Computing, Data Science, Networking, Data security and Privacy, etc. The conference was successful in reaping the advantages of both online and offline modes. The goal of this conference is to give a platform to researchers with fundamental contributions and to be a premier venue for academic and industry practitioners to share new ideas and development experiences. We hope that readers find this book interesting and valuable. We also expect that the conference and its publications will be a trigger for further related research and technology improvements in this important subject.

This reference volume conveys complete understanding and management of Androgenetic Alopecia and Female Pattern Hair Loss (AGA/FPHL). These are probably the most common adult (18-50 yrs.) health disorders besides dental caries, accounting for over 98% of hair loss cases in males and over 70% cases in females. The present volume, the first of three related volumes, is structured in 4 sections: 22 dedicated chapters, ranging from basic science (Biology, Anatomy, Physiology, Embryology), the etiology of adult, childhood & adolescent AGA/FPHL, diagnostic steps and evaluation, to related disorders and comorbidities. For the first time in the scientific literature, all pathogenic contributors of AGA/FPHL, including micro-inflammation, scalp vascularization, biochemical stress, aging, solar radiation, and the sebaceous gland, are examined in comprehensive, dedicated chapters. The effects of every hormone on AGA/FPHL, as well as the psychological impact of the condition, are explored in depth. An extensive chapter on childhood and adolescent AGA/FPHL, a more common than previously thought condition, is another unique feature. Finally, two extremely detailed sections are included on the pathogenic links of AGA/FPHL to life-threatening comorbidities: cardiovascular disease, metabolic syndrome, hypertension, insulin resistance, and prostatic disorders, with suggested guidelines on how to save lives of balding patients by adopting early screening strategies. In providing a fully updated, thorough guide to this popular topic, this richly illustrated volume (over 200 figures, tables, and algorithms) offers the latest, evidence-based information on every aspect of AGA/FPHL causing hair loss to countless patients. Each subject is addressed according to learning and clinical needs, and the presented information is supported by a wealth of peer-reviewed papers. Every aspect of this condition is considered, including biology, diagnosis, etiology, from drug treatment, the influence of nutrition, lifestyle and food supplements, to related disorders, surgical hair restoration, hair care, and future treatment options. This handbook will be an invaluable conveying best management standards to readers, whether experienced practitioners, clinicians, dermatologists, surgeons or researchers interested in hair restoration.

This book addresses the pursuit and further investigation of experimental results by analyzing classic examples from physics. The authors concentrate on the investigation of experimental results by examining case studies from the history of 20th and 21st century physics. Discussions on the discovery of parity nonconservation, the rise and fall of the Fifth Force, the search for neutrinoless double β decay, supersymmetry and the expansion of the Standard Model, and measurements of the anomalous magnetic moment of the muons are provided. Experimental results may achieve acceptance to the point that even well known principles, such as conservation of energy and quantization, lose their status as accepted. Such principles and their options are treated on an equal footing as being pursuit worthy even though there is no plausible explanation as to why and how they might have failed.

This book aims to provide fundamental knowledge and information for research in molecular systematics on parasitic helminths (nematode, trematode, cestode). The shreds of evidence of molecular systematics studies will be compiled and discussed in terms of the utilities and pitfalls of the genetic marker used for various purposes, which have been implemented for molecular systematics of parasitic nematodes, cestodes, and trematodes. Moreover, this book will also provide the procedure for research on molecular systematics and DNA taxonomy as the guideline to explore parasitic helminths. Finally, the further perspectives of utilizing genetic markers for molecular studies on parasitic helminths will be addressed in the context of applications from the laboratory to fieldwork such as DNA barcoding and environmental DNA metabarcoding of parasitic helminths. The book will benefit postgraduate students and researchers requiring the detailed knowledge of molecular systematics,as well as researchers desiring a guideline to select genetic markers and analyze DNA sequences to make phylogenetic inferences

The 21st century has witnessed a considerable and increasing number of political revolutions around the world. This contradicts the popular belief of many experts in the 1970s that revolutions occurred mainly in monarchies and empires. Instead, the revolutions of this century have several new characteristics, which call for a renewed analysis of the subject.This handbook offers a comparative perspective on the new wave of revolutions of the last decade. Presenting case studies on the color revolutions, the Arab revolutions of 2010–2011, and the global wave of revolutions in 2013–2018 that spanned regions ranging from Africa to the Caucasus, it offers a better understanding of the varied forms, features, and historical backgrounds of revolutions, as well as their causes. Accordingly, it highlights recent revolutions in their historical and world-systems contexts.The handbook is divided into seven parts, the first of which examines the history of views on revolution and important aspects of the theory of revolution. The second part analyzes revolutions within long-term historical trends and in their world-system contexts. In turn, the third part explores specific major revolutionary waves in history. The fourth part analyzes the first revolutionary wave of the 21st century (2000–2009), the so-called color revolutions, while the fifth discusses the second wave – the Arab Spring (2010–2013) – as an important turning point. The sixth part is dedicated to analyzing revolutions and revolutionary movements beyond the Arab Spring and some revolutionary events from the third wave that began in 2018. The seventh and final part offers forecasts on the future of revolutions. Given its scope, the book will appeal to scholars and students from various disciplines interested in historical trends, sociopolitical change, contentious politics, social movements, and revolutionary processes involving both nonviolent campaigns and political violence. ​'Once again, this volume demonstrates the kind of open-minded, systematic analysis that the field of revolutionary studies requires.'(Prof. George Lawson, Department of International Relations, Australian National University Canberra)

This contributed volume is dedicated towards the progress achieved within the last years in all areas of Cell Culture Engineering and Technology. It comprises contributions of active researchers in the field of cell culture development for the production of recombinant proteins, cell line development, cell therapy and gene therapy, with consideration of media development, process scale-up, reactor design, monitoring and control and model-assisted strategies for process design. The knowledge and expertise of the authors cover disciplines like cell biology, engineering, biotechnology and biomedical sciences. This book is conceived for graduate students, postdoctoral fellows and researchers interested in the latest developments in Cell Engineering.

“Immersive... bracingly ambitious... rewinds the story of life on Earth—from the mammoth steppe of the last Ice Age to the dawn of multicellular creatures over 500 million years ago.”—The EconomistLONGLISTED FOR THE BAILLIE GIFFORD PRIZE • “One of those rare books that's both deeply informative and daringly imaginative.”—Elizabeth Kolbert, author of Under a White SkyONE OF THE BEST BOOKS OF THE YEAR: The New Yorker, Prospect (UK)The past is past, but it does leave clues, and Thomas Halliday has used cutting-edge science to decipher them more completely than ever before. In Otherlands, Halliday makes sixteen fossil sites burst to life on the page.This book is an exploration of the Earth as it used to exist, the changes that have occurred during its history, and the ways that life has found to adapt―or not. It takes us from the savannahs of Pliocene Kenya to watch a python chase a group of australopithecines into an acacia tree; to a cliff overlooking the salt pans of the empty basin of what will be the Mediterranean Sea just as water from the Miocene Atlantic Ocean spills in; into the tropical forests of Eocene Antarctica; and under the shallow pools of Ediacaran Australia, where we glimpse the first microbial life. Otherlands also offers us a vast perspective on the current state of the planet. The thought that something as vast as the Great Barrier Reef, for example, with all its vibrant diversity, might one day soon be gone sounds improbable. But the fossil record shows us that this sort of wholesale change is not only possible but has repeatedly happened throughout Earth history. Even as he operates on this broad canvas, Halliday brings us up close to the intricate relationships that defined these lost worlds. In novelistic prose that belies the breadth of his research, he illustrates how ecosystems are formed; how species die out and are replaced; and how species migrate, adapt, and collaborate. It is a breathtaking achievement: a surprisingly emotional narrative about the persistence of life, the fragility of seemingly permanent ecosystems, and the scope of deep time, all of which have something to tell us about our current crisis.

The Physical Oceanography of the Arctic Mediterranean Sea describes the circulation and the processes in the Arctic Mediterranean, how our present knowledge has developed, and presents recent changes caused by a gradually warmer global climate.The Arctic Mediterranean Sea has been intensively studied in recent years, especially during the fourth International Polar Year, 2007–09, and we have become increasingly aware of the changes presently taking place. This book collects and presents newly acquired knowledge and sets it in perspective to previous studies. Authored by a world-renowned leader in the field, this book explores the role of this small but important sea in the global oceanic circulation and climate—a must-read for researchers and students in the fields of oceanography and climate science. - Relates observed features to active processes and provides sufficient background information to understand the theoretical explanations - Presents the Arctic Mediterranean Sea in the context of global ocean circulation and climate - Presents a modern, comprehensive, and coherent treatment of Arctic (and subarctic) physical oceanography

Selected as a Doody's Core Title for 2022! Defining the field of immunology for 40 years, Paul's Fundamental Immunology continues to provide detailed, authoritative, up-to-date information that uniquely bridges the gap between basic immunology and the disease process. The fully revised 8th edition maintains the excellence established by Dr. William E. Paul, who passed away in 2015, and is now under new editorial leadership of Drs. Martin F. Flajnik, Nevil J. Singh, and Steven M. Holland. It's an ideal reference and gold standard text for graduate students, post-doctoral fellows, basic and clinical immunologists, microbiologists and infectious disease physicians, and any physician treating diseases in which immunologic mechanisms play a role.

Drawing on the expertise of marine researchers from both the natural and social sciences, this book examines how we, as both scientists and societies, can return to a sustainable co-existence with the ocean and use the tools of transdisciplinarity to bring together the diverse forms of knowledge needed to achieve this important task.The marine sciences play a vital role in producing and providing the knowledge needed for a transition towards ocean sustainability. With a multitude of actors involved in using, exploiting, and safeguarding the seas, however, this task cannot be solved by science alone. Transdisciplinary research is needed, bringing together scientists and all other actors of society to jointly co-produce the knowledge and innovations that we so urgently need. In this context, this book examines and answers key questions at the forefront of transdisciplinary marine research: How can we provide approaches that integrate marine biodiversity and social systems in an appropriate relationship? What methodologies are most suitable to engage stakeholders in participatory processes providing new knowledge and tools for co-designing solutions with balanced socio-ecological embeddedness? How do we best integrate scientific with lay and local knowledge, and how are diverse knowledges valued in engagement activities? How can we reconcile socio-economic activities and the often divergent values attached to them to provide ethical principles for fair and equitable policy decisions? The book addresses these questions by combining an array of chapters about new theoretical approaches to transdisciplinary marine research, methodological considerations, as well as case studies from the nexus of the research and practices of engagement with a variety of stakeholder groups across the globe.This book will be of great interest to students and scholars studying marine science and ocean research across a wide range of disciplines, including marine biology, environmental governance and policy, ocean resource management, oceanography, environmental anthropology, human geography and sustainability. It will also be of interest to those looking to build a greater understanding of transdisciplinary research and knowledge co-production, and practitioners working alongside academics.‘Chapter 1 and Chapter 8 of this book is available for free in PDF format as Open Access from the individual product page at www.routledge.com. It has been made available under a Creative Commons Attribution-Non Commercial-No Derivatives 4.0 license.'

Current Perspectives and New Directions in Mechanics, Modelling and Design of Structural Systems comprises 330 papers that were presented at the Eighth International Conference on Structural Engineering, Mechanics and Computation (SEMC 2022, Cape Town, South Africa, 5-7 September 2022). The topics featured may be clustered into six broad categories that span the themes of mechanics, modelling and engineering design: (i) mechanics of materials (elasticity, plasticity, porous media, fracture, fatigue, damage, delamination, viscosity, creep, shrinkage, etc); (ii) mechanics of structures (dynamics, vibration, seismic response, soil-structure interaction, fluid-structure interaction, response to blast and impact, response to fire, structural stability, buckling, collapse behaviour); (iii) numerical modelling and experimental testing (numerical methods, simulation techniques, multi-scale modelling, computational modelling, laboratory testing, field testing, experimental measurements); (iv) design in traditional engineering materials (steel, concrete, steel-concrete composite, aluminium, masonry, timber); (v) innovative concepts, sustainable engineering and special structures (nanostructures, adaptive structures, smart structures, composite structures, glass structures, bio-inspired structures, shells, membranes, space structures, lightweight structures, etc); (vi) the engineering process and life-cycle considerations (conceptualisation, planning, analysis, design, optimization, construction, assembly, manufacture, maintenance, monitoring, assessment, repair, strengthening, retrofitting, decommissioning). Two versions of the papers are available: full papers of length 6 pages are included in the e-book, while short papers of length 2 pages, intended to be concise but self-contained summaries of the full papers, are in the printed book. This work will be of interest to civil, structural, mechanical, marine and aerospace engineers, as well as planners and architects.

Many companies fail to acknowledge and analyze disparities observed among customers and simply put them down to culture or emotion. New neuroendocrinological research proves that people are rational: They just have a different biological perception of the same stimulus. Their preferences, behavior, and decisions are strongly influenced by the hundreds of millions of sensors monitoring their body and brain. People with more taste buds are, for example, sensitive to bitterness and are more likely to drink their coffee with sugar or milk, or to drink tea. This book helps product managers, marketers, and corporate decision-makers understand and predict customers'behavior and preferences. It provides the tools to design the right sensory mix (color, shape, depth, taste, smell, texture, and sound) for each product, and fine-tune their positioning and range for every local market. Using cases from different sectors, the author shows that this approach delivers planet and people-friendly innovations which have a higher chance of success in the market.

This book analyses the impact of the COVID-19 pandemic in different areas of Finance emphasizing the contagion effect in capital markets. The volume presents evidence-based case studies from the global financial crisis that followed after the onset of the pandemic in March 2020.

This monograph provides a comprehensive introduction to the theory of complex normal surface singularities, with a special emphasis on connections to low-dimensional topology. In this way, it unites the analytic approach with the more recent topological one, combining their tools and methods.In the first chapters, the book sets out the foundations of the theory of normal surface singularities. This includes a comprehensive presentation of the properties of the link (as an oriented 3-manifold) and of the invariants associated with a resolution, combined with the structure and special properties of the line bundles defined on a resolution. A recurring theme is the comparison of analytic and topological invariants. For example, the Poincaré series of the divisorial filtration is compared to a topological zeta function associated with the resolution graph, and the sheaf cohomologies of the line bundles are compared to the Seiberg–Witten invariants of the link. Equivariant Ehrhart theory is introduced to establish surgery-additivity formulae of these invariants, as well as for the regularization procedures of multivariable series.In addition to recent research, the book also provides expositions of more classical subjects such as the classification of plane and cuspidal curves, Milnor fibrations and smoothing invariants, the local divisor class group, and the Hilbert–Samuel function. It contains a large number of examples of key families of germs: rational, elliptic, weighted homogeneous, superisolated and splice-quotient. It provides concrete computations of the topological invariants of their links (Casson(–Walker) and Seiberg–Witten invariants, Turaev torsion) and of the analytic invariants (geometric genus, Hilbert function of the divisorial filtration, and the analytic semigroup associated with the resolution). The book culminates in a discussion of the topological and analytic lattice cohomologies (as categorifications of the Seiberg–Witten invariant and of the geometric genus respectively) and of the graded roots. Several open problems and conjectures are also formulated.Normal Surface Singularities provides researchers in algebraic and differential geometry, singularity theory, complex analysis, and low-dimensional topology with an invaluable reference on this rich topic, offering a unified presentation of the major results and approaches.

Emerging Practices in the Age of Automated Digital Journalism provides detailed insight into the current state of journalism and its future challenges. The book brings together a global team of authors to review and analyse emerging practices in the automated digital scenario through which journalism is being reshaped, such as novel languages, storytelling forms, and business models. Providing a much-needed review of the field to apprehend the knowledge and experience acquired, the collection also offers an up-to-date overview of digital journalism today, outlining those trends pointing to the future of journalism practice and media in the online sphere.Through a multidisciplinary and international approach, chapters delve into the main technological changes that digital journalism has recently faced, closely related to digital native media, novel storytelling forms, social media, innovation, television broadcasting, new media management structures and procedures, content automation, fact-checking, web analytics, and social audiences.Offering new insights into this fast-developing area, this volume will be an engaging and vital resource for media professionals and researchers in journalism and communication studies, as well as those interested in contemporary journalism practice and communication technology.