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This two volume-set LNCS 13769 and LNCS 14092 constitutes the refereed proceedings of the 8th International MICCAI Brainlesion Workshop, BrainLes 2022, as well as the Brain Tumor Segmentation (BraTS) Challenge, the Brain Tumor Sequence Registration (BraTS-Reg) Challenge, the Cross-Modality Domain Adaptation (CrossMoDA) Challenge, and the Federated Tumor Segmentation (FeTS) Challenge. These were held jointly at the Medical Image Computing for Computer Assisted Intervention Conference, MICCAI 2022, in September 2022. The 46 revised full papers presented in these volumes were selected form 65 submissions.The presented contributions describe the research of computational scientists and clinical researchers working on brain lesions - specifically glioma, multiple sclerosis, cerebral stroke, traumatic brain injuries, vestibular schwannoma, and white matter hyper-intensities of presumed vascular origin.

This book constitutes the refereed proceedings of the 8th International MICCAI Brainlesion Workshop, BrainLes 2022, as well as the Brain Tumor Segmentation (BraTS) Challenge, the Brain Tumor Sequence Registration (BraTS-Reg) Challenge, the Cross-Modality Domain Adaptation (CrossMoDA) Challenge, and the Federated Tumor Segmentation (FeTS) Challenge. These were held jointly at the Medical Image Computing for Computer Assisted Intervention Conference, MICCAI 2022, in September 2022. The 46 revised full papers presented in these volumes were selected form 65 submissions.The presented contributions describe the research of computational scientists and clinical researchers working on brain lesions - specifically glioma, multiple sclerosis, cerebral stroke, traumatic brain injuries, vestibular schwannoma, and white matter hyper-intensities of presumed vascular origin.

This two-volume set LNCS 12962 and 12963 constitutes the thoroughly refereed proceedings of the 7th International MICCAI Brainlesion Workshop, BrainLes 2021, as well as the RSNA-ASNR-MICCAI Brain Tumor Segmentation (BraTS) Challenge, the Federated Tumor Segmentation (FeTS) Challenge, the Cross-Modality Domain Adaptation (CrossMoDA) Challenge, and the challenge on Quantification of Uncertainties in Biomedical Image Quantification (QUBIQ). These were held jointly at the 23rd Medical Image Computing for Computer Assisted Intervention Conference, MICCAI 2020, in September 2021. The 91 revised papers presented in these volumes were selected form 151 submissions. Due to COVID-19 pandemic the conference was held virtually.

This two-volume set LNCS 12962 and 12963 constitutes the thoroughly refereed proceedings of the 7th International MICCAI Brainlesion Workshop, BrainLes 2021, as well as the RSNA-ASNR-MICCAI Brain Tumor Segmentation (BraTS) Challenge, the Federated Tumor Segmentation (FeTS) Challenge, the Cross-Modality Domain Adaptation (CrossMoDA) Challenge, and the challenge on Quantification of Uncertainties in Biomedical Image Quantification (QUBIQ). These were held jointly at the 23rd Medical Image Computing for Computer Assisted Intervention Conference, MICCAI 2020, in September 2021. The 91 revised papers presented in these volumes were selected form 151 submissions. Due to COVID-19 pandemic the conference was held virtually.

This two-volume set LNCS 12658 and 12659 constitutes the thoroughly refereed proceedings of the 6th International MICCAI Brainlesion Workshop, BrainLes 2020, the International Multimodal Brain Tumor Segmentation (BraTS) challenge, and the Computational Precision Medicine: Radiology-Pathology Challenge on Brain Tumor Classification (CPM-RadPath) challenge. These were held jointly at the 23rd Medical Image Computing for Computer Assisted Intervention Conference, MICCAI 2020, in Lima, Peru, in October 2020.• The revised selected papers presented in these volumes were organized in the following topical sections: brain lesion image analysis (16 selected papers from 21 submissions); brain tumor image segmentation (69 selected papers from 75 submissions); and computational precision medicine: radiology-pathology challenge on brain tumor classification (6 selected papers from 6 submissions). •The workshop and challenges were held virtually.

This two-volume set LNCS 12658 and 12659 constitutes the thoroughly refereed proceedings of the 6th International MICCAI Brainlesion Workshop, BrainLes 2020, the International Multimodal Brain Tumor Segmentation (BraTS) challenge, and the Computational Precision Medicine: Radiology-Pathology Challenge on Brain Tumor Classification (CPM-RadPath) challenge. These were held jointly at the 23rd Medical Image Computing for Computer Assisted Intervention Conference, MICCAI 2020, in Lima, Peru, in October 2020.• The revised selected papers presented in these volumes were organized in the following topical sections: brain lesion image analysis (16 selected papers from 21 submissions); brain tumor image segmentation (69 selected papers from 75 submissions); and computational precision medicine: radiology-pathology challenge on brain tumor classification (6 selected papers from 6 submissions). •The workshop and challenges were held virtually.

The two-volume set LNCS 11992 and 11993 constitutes the thoroughly refereed proceedings of the 5th International MICCAI Brainlesion Workshop, BrainLes 2019, the International Multimodal Brain Tumor Segmentation (BraTS) challenge, the Computational Precision Medicine: Radiology-Pathology Challenge on Brain Tumor Classification (CPM-RadPath) challenge, as well as the tutorial session on Tools Allowing Clinical Translation of Image Computing Algorithms (TACTICAL). These were held jointly at the Medical Image Computing for Computer Assisted Intervention Conference, MICCAI, in Shenzhen, China, in October 2019. The revised selected papers presented in these volumes were organized in the following topical sections: brain lesion image analysis (12 selected papers from 32 submissions); brain tumor image segmentation (57 selected papers from 102 submissions); combined MRI and pathology brain tumor classification (4 selected papers from 5 submissions); tools allowing clinical translation of image computing algorithms (2 selected papers from 3 submissions.)

The two-volume set LNCS 11992 and 11993 constitutes the thoroughly refereed proceedings of the 5th International MICCAI Brainlesion Workshop, BrainLes 2019, the International Multimodal Brain Tumor Segmentation (BraTS) challenge, the Computational Precision Medicine: Radiology-Pathology Challenge on Brain Tumor Classification (CPM-RadPath) challenge, as well as the tutorial session on Tools Allowing Clinical Translation of Image Computing Algorithms (TACTICAL). These were held jointly at the Medical Image Computing for Computer Assisted Intervention Conference, MICCAI, in Shenzhen, China, in October 2019. The revised selected papers presented in these volumes were organized in the following topical sections: brain lesion image analysis (12 selected papers from 32 submissions); brain tumor image segmentation (57 selected papers from 102 submissions); combined MRI and pathology brain tumor classification (4 selected papers from 5 submissions); tools allowing clinical translation of image computing algorithms (2 selected papers from 3 submissions.)

This two-volume set LNCS 11383 and 11384 constitutes revised selected papers from the 4th International MICCAI Brainlesion Workshop, BrainLes 2018, as well as the International Multimodal Brain Tumor Segmentation, BraTS, Ischemic Stroke Lesion Segmentation, ISLES, MR Brain Image Segmentation, MRBrainS18, Computational Precision Medicine, CPM, and Stroke Workshop on Imaging and Treatment Challenges, SWITCH, which were held jointly at the Medical Image Computing for Computer Assisted Intervention Conference, MICCAI, in Granada, Spain, in September 2018. The 92 papers presented in this volume were carefully reviewed and selected from 95 submissions. They were organized in topical sections named: brain lesion image analysis; brain tumor image segmentation; ischemic stroke lesion image segmentation; grand challenge on MR brain segmentation; computational precision medicine; stroke workshop on imaging and treatment challenges.

This two-volume set LNCS 11383 and 11384 constitutes revised selected papers from the 4th International MICCAI Brainlesion Workshop, BrainLes 2018, as well as the International Multimodal Brain Tumor Segmentation, BraTS, Ischemic Stroke Lesion Segmentation, ISLES, MR Brain Image Segmentation, MRBrainS18, Computational Precision Medicine, CPM, and Stroke Workshop on Imaging and Treatment Challenges, SWITCH, which were held jointly at the Medical Image Computing for Computer Assisted Intervention Conference, MICCAI, in Granada, Spain, in September 2018. The 92 papers presented in this volume were carefully reviewed and selected from 95 submissions. They were organized in topical sections named: brain lesion image analysis; brain tumor image segmentation; ischemic stroke lesion image segmentation; grand challenge on MR brain segmentation; computational precision medicine; stroke workshop on imaging and treatment challenges.

This book constitutes revised selected papers from the Third International MICCAI Brainlesion Workshop, BrainLes 2017, as well as the International Multimodal Brain Tumor Segmentation, BraTS, and White Matter Hyperintensities, WMH, segmentation challenges, which were held jointly at the Medical Image computing for Computer Assisted Intervention Conference, MICCAI, in Quebec City, Canada, in September 2017. The 40 papers presented in this volume were carefully reviewed and selected from 46 submissions. They were organized in topical sections named: brain lesion image analysis; brain tumor image segmentation; and ischemic stroke lesion image segmentation.

This book constitutes the thoroughly refereed post-workshop proceedings of the International Workshop on Brain Lesion, as well as the challenges on Brain Tumor Segmentation (BRATS), Ischemic Stroke Lesion Image Segmentation (ISLES), and the Mild Traumatic Brain Injury Outcome Prediction (mTOP), held in Athens, October 17, 2016, in conjunction with the International Conference on Medical Image Computing and Computer-Assisted Intervention, MICCAI 2016. The 26 papers presented in this volume were carefully reviewed. They present the latest advances in segmentation, disease prognosis and other applications to the clinical context.

This book constitutes the thoroughly refereed post-workshop proceedings of the International Workshop on Brain Lesion (BrainLes), Brain Tumor Segmentation (BRATS) and Ischemic Stroke Lesion Segmentation (ISLES), held in Munich, Germany, on October 5, 2015, in conjunction with the International Conference on Conference on Medical Image Computing and Computer-Assisted Intervention, MICCAI 2015. The 25 papers presented in this volume were carefully reviewed and selected from 28 submissions. They are grouped around the following topics: brain lesion image analysis; brain tumor image segmentation; ischemic stroke lesion image segmentation.