Search

Fortschritte bei der Erforschung, Diagnostik und Therapie chronisch entzündlicher Darmkrankheiten (CED) bedürfen in zunehmendem Maße einer interdisziplinären Kooperation von klinischen Gastroenterologen, Radiologen, Immunologen, Dermatologen und Rheumatologen. Der vorliegende Band fasst den aktuellen Stand zu extraintestinalen Komplikationen chronisch entzündlicher Darmkrankheiten zusammen. Eingehend und kritisch diskutiert werden Manifestationen an der Haut, die wichtige Komplikation der Osteopenie, Gelenkmanifestationen und Leberveränderungen. Es werden Spezialaspekte von CED in diesem Buch aktuell und in klinsch relevanter Bedeutung dargestellt. Wichtige therapeutische Probleme und Lösungsvorschläge, auf die wir häufig auch beim vermeintlich unkomplizierten M. Crohn stoßen, werden aufgezeigt.

As we began to plan this book about 10 years ago, we wanted to write a practical book for medical students, doctors in training, internists, gas­ and surgeons faced with everyday clinical problems in troenterologists, the care of patients with acute and chronic pancreatitis. Now, 10 years lat­ er, our book has become much more than what we had originally intend­ ed, with so many new findings that have expanded our knowledge of pancreatic diseases, not to mention new imaging procedures and con­ trolled studies on the effectiveness of various therapies. Consequently, we decided to include: • The state-of-the-art on diagnosis and therapy in inflammatory pan­ creatic diseases • Recommendations for diagnosis and therapy based on the published results from experienced clinicians. In the many areas still untested we have relied on the decades of experience of the two authors on both sides of the Atlantic • A discussion of unanswered questions for future research by physi­ cians interested in pancreatitis who can draw upon our bibliography of almost 1900 references complete through 1996. We also wanted to demonstrate with this work that two authors from two continents can come to common conclusions that can help physicians and students in their everyday clinical work and their clinical research. It is with deep gratitude that we acknowledge the assistance of Mrs. Gisela Ropte for years of patient cooperation, great precision, and initia­ tive, as well as that of Dr. Dr.

Die Inzidenz der bösartigen Tumoren der oberen Luft- und Speisewege nimmt eindeutig zu. Diese im Hals-Bereich lokalisierten (zumeist Plattenepithel-) Karzinome gehen häufig mit dort lokalisierten Lymphknotenmetastasen einher. Häufig fallen sie durch diese überhaupt erst auf, zumal der Primärtumor gelegentlich kaum Beschwerden bereitet. Das vorliegende Buch bietet als Nachschlagewerk einen umfassenden Überblick der für alle Ärzte (auch Internisten, Allgemeinmediziner und Dermatologen) absolut notwendigen Kenntnis um die Differenzialdiagnostik der Lymphknotenerkrankungen und deren Therapie, insbesondere der verschiedenen Formen der Neck-Dissection. Hochqualitative Abbildungen und Tabellen ermöglichen es, die Thematik mit hohem didaktischen Wert vorzustellen.

The discovery and concept that Helicobacter pylori is associated with gastric disease including gastric cancer which is one of the most common and frequently lethal forms of malignancy, heralded a new and rapidly expanding field recognizing the emergence of many new pathogens and disease syndromes in clinical medicine, as well as basic infectious disease research. There is now an extensive and widely known literature of how H. pylori is involved in a wide variety of disease syn­ dromes. As summarized in the introductory chapter of this volume, many major advances have been made in diagnosis, both serologic and endoscopic in time of the involvement of this organism in patients with upper GI ailments as well as its presence in those who are not clinically ill. The Introduction describes the rapid development of understanding the role of this organism in disease. The basic bacteriology of H. pylori is then described in the second chapter. Diagnostic tests for detecting H. pylori infection is then highlighted, as well as the role of such infection in gastric cancer. Current knowledge concerning risk factors and peptic ulcer pathology associated with H. pylori is then described. Newer information concerning therapy of H. pylori infection and colonization is described in a subsequent chapter as well as one concerning the effects of anti­ biotics on H. pylori infection. The extensive literature on natural substances with anti-H.

There have been many advances in the field of gastrointestinal pa­ thology which are of considerable clinical significance during the 13 years since the last publication of a volume of Current Topics in Pathology devoted to this subject. Many have arisen from the app­ lication of new techniques of histochemistry, immunocytochemi­ stry, quantitative morphometry and molecular and cell biology to gastrointestinal diseases, but some, notably the recognition of the association of Campylobaeter pylori with the commonest type of chronic gastritis, have been achieved using such long established'routine'histological procedures that one wonders how their signifi­ cance had escaped recognition for so long. The topics covered in this volume have been selected because they present advances of relevance to the diagnostic clinical pathologist. However, they re­ present the personal selection of the editor, and are in no way exhaustive. Many other examples of progress in our understanding of the pathophysiology of gastrointestinal diseases have been omit­ ted, either because of the confines of space or because they have been well reviewed recently in other publications. Most of the workload of the practising gastrointestinal patholo­ gist involves the diagnosis and assessment either of inflammation or of neoplasia in the alimentary tract, and this is reflected in the topics presented in this book.

At the beginning of the century the average life span in developed societies was less than 50 years. It is now more than 70 years and will continue to increase in the near future. Aging is a challenge to science and society. There are several theories of aging. The programmed aging hypothesis suggests that aging cannot be altered by any external influence, that aging is programmed from the beginning of life until the end of senescence. Another theory is based on genetic instability, with repair processes correcting errors in the cells that cause aging. Aging processes manifest themselves at the molecular and cellular level, in different organs, and in the whole organism. Most older persons acquire multiple diseases, primarily chronic ones. The multimorbidity of the elderly raises many questions as to nutrition, metabolism, immunity, drug therapy, and rehabilitation. Nutrition may be able to intervene in the aging process. Aging is associated with dec­ lining immunity and reduced resistance to many diseases, and it is pos­ sible that nutritional changes in old age contribute to the declining immunity in the elderly. The elderly take 40% of the prescription drugs in Germany and adverse drug reactions are more frequent in geriatric patients. There are not only problems in drug therapy for elderly pa­ tients, but also in their rehabilitation. The aim of rehabilitation is the restoration of geriatric patients to their former functional and environ­ mental status.