Search

Dissemination of knowledge is the best and only strategy capable of improving clinical management in rare and ultra-rare malignancies, including primary adrenal malignancies. It is preliminary to any further healthcare policy such as, for example, the centralization of cases in referral institutions. Adrenal primary malignancies are probably the rarest among rare pathologies. This epidemiological consideration is at the origin of a vicious circle: the lack of preoperative diagnosis leads to inappropriate surgical procedures and to inadequate follow-up and systemic therapy strategies. Furthermore, when malignancy is recognized, the relative role of systemic, surgical, or other local ablative techniques is often misinterpreted. All this produces a negative impact on survival, also in patients who could have been cured with a correct therapeutic strategy. This open access book provides a user-friendly exploration of these rare conditions, using a transversal approach common in modern precision medicine. The text covers various clinical aspects, including epidemiology, genetics, molecular medicine, imaging, and surgery. Guidelines for managing syndromic situations are provided. The book thoroughly addresses all the different surgical issues and emphasizes the importance of pathology in assessing prognosis. The pivotal role of medical oncologists in managing these patients is explored, along with alternative treatments such as nuclear medicine and radiotherapy. Finally, the book highlights the latest preclinical research and its implications for translational medicine.

In the articles included in this collection, Professor Daniel argues that Abbot Joachim of Fiore was a disciple of Bernard of Clairvaux whose tertius status was reformist, not millenialist. Like the other reformists, Gerhoch of Reichersberg and Hildegard of Bingen, Joachim looked forward to the coming of a thoroughly reformed, holy church to be achieved in the near future by reform of the episcopate and the clergy. The status of the Holy Spirit was the culmination of the preceding status, not a radically new beginning. Apocalypticism in both its reformist and in its imperialist versions was part of the mainstream, despite the efforts of the schoolmen to suppress it. The author also sheds significant new light on apocalyptic thinking in the mid-fourteenth century with a thorough analysis of Henry of Kirkstede's vade mecum, Cambridge Corpus Christi 404 and his first edition of Henry's De antichristo et de fine mundi. This study, and three others, are published here for the first time.

This book constitutes the proceedings of the 12th International Conference on Data Management Technologies and Applications, DATA 2023, held in Rome,Italy during July 11–13, 2023, Proceedings. The 6 full paper were carefully reviewed and selected from 106 submissions. The papers are organized in subject areas as follows: Big Data Applications, Data Analytics, Data Science, NoSQL Databases, Social Data Analytics, Dimensional Modelling, Deep Learning and Big Data, Decision Support Systems, Data Warehouse Management and Data Management for Analytics.

Unlocking the Future of Infectious Disease Research ResponseIn a world where emerging infectious diseases constantly threaten humanity, advances in science and technology promise defense against future pathogens before they cause pandemics. The field of emergency research response and preparedness remains in its infancy, however. Not until the 2014 West African Ebola outbreak was accelerated research broadly recognized as a crucial component of emergency response. Many outbreaks and one global pandemic later, it is clear the world must be prepared to launch accelerated research responses to prevent or mitigate infectious disease outbreaks, epidemics, and pandemics. Yet this nascent field is rife with critical scientific, ethical, and policy questions. How can local, national, and global systems collaborate across disciplines and political boundaries to protect health security? How can we conduct rigorous research in fragile or failed nation-states? What is needed for equitable distribution of vaccines and therapeutic medicines in short supply? How can we accelerate trials of vaccines and therapeutics during an emergency without compromising scientific rigor or ethical standards? How do we integrate communities and stakeholders into research preparedness and response? The editors bring decades of experience to their collaboration with renowned research scientists and health policy experts. Together they have crafted a compendium that proposes normative standards and offers practical guidance for preparedness and rapid research response. This pioneering, open access textbook presents principles and practices forged from experience in health emergencies – insights that illuminate a path forward for research response and preparedness. The goal is to stop outbreaks from becoming avoidable pandemics, and to mitigate illness, death, and social disruption if they cannot be stopped. Principles and Practice of Emergency Research Response merges historical understanding with insights into possible futures. It will serve as an indispensable compass for curtailing infectious disease threats through research, global health policy changes, and research capacity improvements where they are most needed. The editors hope that this book will be an ongoing reference for governments, health organizations, development agencies, researchers, policy experts, ethicists, and social scientists. To facilitate focused and enhanced learning, it incorporates pedagogical tools such as abstracts, learning objectives, discussion questions, real-life examples, and learning tracks. Robust global health security requires effective preparation for and response to emerging and re-emerging pathogens. This volume should help guide us towards a more resilient future.

This is an open access book. On behalf of the Organizing Committee, it gives me great pleasure to invite you to be part of the 9th Mathematics, Science, and Computer Science Education International Seminar (MSCEIS) which will be held in Bandung, October 21th 2023. This conference is the biannual meeting of academia, researchers, and practitioner from across the country and the globe, and is organized by Faculty of Mathematics and Science Education, Indonesia University of Education. This conference provides great opportunities for strengthening collaboration as well as network not only with international but also national participants. The theme for the MSCEIS 2023 is “Shaping the Future: Trends and Insights in Mathematics, Computer, and Science Education researches to Support SDG's”. We are confident that this conference will be a successful scientific gathering and will give a better platform for all participants to engage in meaningful conversations and share research ideas. This conference intends to bring together researchers, academicians, scientists and industrialists from across the world to discuss cutting-edge research and development, as well as identify futuristic trends and needs in the domains of chemistry and related fields such as Chemistry, Chemistry Education, Physic, Physic Education, Mathematic, Mathematic Education, Biology, Biology Education, Science Education, Computer Science, and Computer Science Education. It will include keynote and invited lectures, oral and poster presentations from distinguished professors and participants. The attendees will get also the opportunity to share ideas as well as develop professional relationships and locate global partners for future collaboration. We look forward to welcoming you to be part of MSCEIS in Bandung, 2023. We are very confident that this conference will be an intellectually exciting and enjoyable event for all.

O livro Regulação da Temperatura Corporal: Exercício Físico, Desempenho e Saúde aborda um tema central e atual no campo da fisiologia e da prescrição de exercícios físicos. Esta é a primeira obra no Brasil dedicada inteiramente ao estudo de como o corpo humano responde durante a prática de exercícios físicos em diferentes ambientes térmicos, principalmente nos ambientes quentes. Este tema é de extrema importância no cenário atual de aquecimento global, em que as pessoas irão conviver e se exercitar em ambientes cada vez mais quentes. Assim, este livro se propõe a ser uma obra de consulta fundamental aos professores, estudantes e profissionais envolvidos com as ciências do esporte, atletas de rendimentos e amadores, bem como ao público praticante de atividades físicas em geral. Além disso, temas importantes como os efeitos do treinamento aeróbio e de força, hidratação, crianças, envelhecimento, deficiências, hipertensão arterial, diabetes, obesidade, avaliação do estresse térmico ambiental, fadiga durante o exercício físico, cronobiologia, termografia, inflamação sistêmica, efeitos termogênicos dos alimentos, dentre outros, são abordados. O leitor encontrará também uma profunda revisão das bases termorregulatórias. Cabe ressaltar que todo o conteúdo do livro foi pensado numa linguagem clara e de fácil entendimento.

This insightful book explores the impact of internet-based technologies on second language acquisition, focusing on informal learning. It traces the evolution of informal learning, emphasizing the crucial role of input, interaction, and output in acquiring English as a second language. The book analyzes diverse out-of-school practices, such as watching TV, gaming, and social media engagement, and their impact on L2 development. Additionally, it delves into various intervening variables—age, gender, proficiency, engagement, and affective variables—highlighting the personalized nature of L2 acquisition. It also addresses the challenges encountered by L2 teachers, advocating innovative teaching methods to bridge the gap between classroom teaching and the real world. This book is an invaluable resource for enthusiasts interested in the intersection of language acquisition, teaching methodologies, and modern technologies.

This book highlights the usefulness of magnetic resonance imaging (MRI) for the evaluation of lung and thoracic tumors. MRI will become a standard examination for lung cancer, pulmonary nodules/masses, and thoracic neoplasms. This is due to it being economical and providing no radiation exposure to patients. Compared to computerized tomography (CT), MRI allows for qualitative analysis of benign or malignant disease, not just morphology. Compared to positron emission tomography–computed tomography (PET-CT), MRI enables early assessment of therapeutic effects, is inexpensive, and does not require radioactive isotopes. This book is useful for the assessment of lung and thoracic neoplasms and should be recommended reading for doctors dealing with thoracic diseases. Those who will find this book most useful are physicians, respiratory physicians, radiologists and thoracic surgeons who are interested in MRI examinations, as well as MRI companies, general hospitals and publishers of radiology.

Life in all its forms is based on nucleic acids which store and transfer genetic information. The book addresses main aspects of synthesis, hydrolytic stability and solution equilibria of nucleosides, nucleotides and oligonucleotides, as well as synthesis of their structural analogs that are of interest in chemotherapy. In addition, recent achievements in chemistry of catalytic nucleic acids, development of oligonucleotide based drugs and novel strategies for their targeting and delivery are discussed. The central theme always is the correlation of structure and function.

This book highlights recent research on intelligent systems and machine learning based solutions. It presents 46 selected papers focused on Industrial Applications from the 23rd International Conference on Intelligent Systems Design and Applications (ISDA 2023), which was held in 5 different cities namely Olten, Switzerland; Porto, Portugal; Kaunas, Lithuania; Greater Noida, India; Kochi, India, and in online mode. The ISDA is a premier conference in the field of artificial intelligence, and the latest installment brought together researchers, engineers, and practitioners whose work involves intelligent systems and their applications in industry. ISDA 2023 had contributions by authors from 64 countries. This book offers a valuable reference guide for all industrial specialists, scientists, academicians, researchers, students, and practitioners in the field of artificial intelligence and industrial applications.

Das Standardwerk für alle in der Geburtshilfe und Perinatalmedizin tätigen Ärztinnen und Ärzte und Interessierte liegt nun unter neuer Herausgeberschaft vor. In der 6. Auflage komplett aktualisiert und dem aktuellen evidenzbasierten Wissen und Methoden angepasst. Mehr als die Hälfte der Kapitel mit neuer Autorenschaft und erweitert um neue Themen, u.a. Adipositas und Schwangerschaft, Geburtsmodus bei fetalen Fehlbildungen, Management von Placenta increta, Patient Blood Management. Plus: Von der Evidenz zur Handlungsempfehlung, praktisches geburtshilfliches multiprofessionelles Traning. „Die Geburtshilfe“ beantwortet die zahlreichen Fragen, die sich Ärztinnen und Ärzte und Hebammen rund um die Themen Schwangerschaft, Geburt und Perinatalmedizin stellen. Verständlich, klar strukturiert und an der Praxis orientiert mit eindeutigen Angaben zur Dosierung von Medikamenten, Algorithmen und Hinweisen auf Komplikationen. Als ebook und Live-Reference ermöglicht es den direkten Zugriff zu jeder Zeit sowie auf Links zu wichtigen Websites. Für eine kompetente und einfühlsame Betreuung und Begleitung der werdenden Mutter von der Schwangerschaft bis nach der Entbindung.

This volume consists of a collection of empirical studies and research syntheses investigating the role of individual difference (ID) variables in task-based language teaching (TBLT)—a pedagogical approach that emphasizes the importance of the performance of meaning-oriented tasks in facilitating second language learning. TBLT is subject to learner-external as well as learner-internal factors, with the former referring to task- and context-related factors, and the latter to ID factors pertaining to learner traits, dispositions, or propensities. To date, the research has focused primarily on learner-external factors, and there has been insufficient and unsystematic research on individual difference factors. This volume brings centre stage this important but under-researched dimension by means of a comprehensive, in-depth examination of the role of key ID factors in TBLT. The volume integrates theory, research, and pedagogy by spelling out the mechanism through which IDs influence learning attainment, behaviours, and processes, examining evidence for theoretical claims, and discussing ways to apply research findings and cater to individual differences in the task-based classroom.

This state-of-the-science handbook offers a comprehensive discussion of input processing in second language acquisition. The volume assesses past and current research on input processing and engages the reader in critical reflection about the current state of the field and what lies ahead for future research, theory-building, and implications for language instruction.The handbook considers multiple theoretical perspectives, pivotal research findings, issues in research methodology, and instructional implications that underscore the centrality of input processing in second language acquisition. Whereas to date most research in this area has focused on input processing as it relates to the acquisition of morphosyntax and lexis, the present volume also attends to more recent theoretical advances regarding other linguistic subsystems, such as phonology and pragmatics, as well as processing resource allocation during multilevel input processing.Thorough and forward-looking, this volume is an indispensable resource to scholars and advanced students of second language acquisition, bilingualism, applied linguistics, cognitive science, psychology, and education.

The second edition of The Chemistry of Clay-Organic Reactions book provides a comprehensive and fully updated summary of the literature on the interactions of clay minerals with organic molecules, including reaction mechanisms and bonding modes together with their practical and industrial applications. The reader will gain an insight into the formation and properties of complexes between clay minerals and a variety of organic compounds and the use of such complexes as sorbents and carriers of organic pollutants, pesticides, dyes, and pharmaceuticals.KEY FEATURES An authoritative resource providing a detailed synthesis of published data on clay-organic complexes and reactions. Authored by a globally recognized expert in the field. Describes developments in the interactions of organic compounds with fibrous and short-range order clay minerals. This book is written for environmental and industrial chemists, organic geochemists, and soil scientists, and it will appeal to academics, researchers, industry professionals, and graduate students.

This comprehensive book explores both the fundamental and practical aspects of microbial genetics, shedding light on viroids, viruses, phytoplasma, bacteria, fungi, and protozoa. Unveiling a fresh perspective, the book tackles traditional taxonomical debates by embracing DNA-based taxonomy, offering a novel approach to understanding phylogeny within this microbe realm. Furthermore, it delves into the exciting realm of metagenomics, revolutionizing the identification and classification of unculturable microorganisms. Written by leading experts, this essential reading material caters to students and researchers in Microbiology, Genetics, and Biotechnology.

Texts of 108 songs of the Dutch Reformed, with an introduction, a bibliography (63 entries), etc.

There are different types of treatment for breast cancer, including surgery, chemotherapy, radiotherapy, hormone therapy, immunotherapy, and targeted therapy. Deciding on the types of treatment depends on several factors, such as the stage and grade of cancer, biomarkers, and general health of patients. The seventh volume of the “Interdisciplinary Cancer Research” series, entitled “Breast Cancer Treatment: An Interdisciplinary Approach” publishes comprehensive reviews on different treatment opportunities on breast cancer. An update on treatment of triple-negative breast cancer and ductal carcinoma in situ is provided. Ablative breast cancer surgery, radiotherapy, and percutaneous breast cancer treatment are explained. Promising hormone immunotherapy combination as well as targeted therapies for breast cancer is also discussed. This interdisciplinary series is of special value to researchers working on oncology. This is the main concept of Cancer Immunology Project (CIP), which is a part of Universal Scientific Education and Research Network (USERN). This interdisciplinary book will be of special value to researchers and oncologists who wish to extend their knowledge on breast cancer treatment.

L'analisi proposta in questo libro si focalizza su particolari deformazioni delle regole di commutazione canoniche suggerite dal recente, e sempre crescente, interesse per la meccanica quantistica PT-simmetrica. Se ne considerano diverse conseguenze di natura matematica, ma anche loro possibili applicazioni alla fisica. Queste includono l'analisi di diverse Hamiltoniane non autoaggiunte, il calcolo di integrali di cammino associati a tali Hamiltoniane per mezzo di stati bi-coerenti, ed una nuovo punto di vista sugli operatori posizione e momento. Il libro è prevalentemente destinato ai ricercatori ma è anche pensato per essere fruibile da studenti di magistrale e di dottorato. Fornisce inoltre una introduzione ad alcuni aspetti delicati dell'analisi funzionale e della meccanica quantistica per osservabili non autoaggiunte.

New Challenges in Rock Mechanics and Rock Engineering includes the contributions presented at the ISRM European Rock Mechanics Symposium Eurock 2024 (Alicante, Spain, 15-19 July 2024), and explores cutting-edge advancements in rock mechanics and rock engineering. This comprehensive compilation covers various aspects of rock mechanics and rock engineering, including: rock properties, testing methods, infrastructure and mining rock mechanics, design analysis, stone heritage preservation, geophysics, numerical modeling, monitoring techniques, underground excavation support, risk assessment, and the application of EUROCODE-7 in rock engineering. Furthermore, it addresses areas like geomechanics for the oil and gas industry, applications of artificial intelligence, remote sensing methodologies and geothermal technology.New Challenges in Rock Mechanics and Rock Engineering covers the latest breakthroughs and tackles the new challenges in rock mechanics and rock engineering, is aimed at scientists and professionals in these fields, and serves as an essential resource for keeping up to date with industry trends and solutions.

Essentially a bio-bibliography of the Bonn prototypographer Laurenz van der Mülen. With bibliography 1541-1553.

The 34th European Symposium on Computer Aided Process Engineering / 15th International Symposium on Process Systems Engineering, contains the papers presented at the 34th European Symposium on Computer Aided Process Engineering / 15th International Symposium on Process Systems Engineering joint event. It is a valuable resource for chemical engineers, chemical process engineers, researchers in industry and academia, students, and consultants for chemical industries. Presents findings and discussions from the 34th European Symposium on Computer Aided Process Engineering / 15th International Symposium on Process Systems Engineering joint event

Peritoneal Tumor Microenvironment of Cancers on Cancer Hallmarks: Perspectives of Translational Medicine provides readers with cutting-edge knowledge on tumor microenvironment. By exploring multiple aspects on tumor microenvironment, it gives an integrative insight on cancer diseases ranging from diagnosis to prediction of prognosis and individualized treatment.The book discusses topics such as clinical significance of tumor microenvironment, tumorigenesis and cancer progression, histopathological features of cancer in peritoneum, immune cells in tumor, exosomal cell-to-cell interactions, and therapeutic approaches to target tumor microenvironment. Additionally, it discusses tumor evolution during chemotherapy and metastasis, and future perspectives on identification and validation of biomarkers using liquid biopsy.This book is a valuable resource for cancer researchers, oncologists, medical doctors, and several members of biomedical field who want to understand the complex microenvironment of peritoneal tumors.Discusses how to apply tumor microenvironment knowledge to diagnosis, prediction of prognosis, and individualized treatment of cancerProvides readers with up-to-date knowledge on translational medicine, focusing on bench-to-bedside approach for cancer treatment and diagnosisPresents collaborative research works from the perspectives of medical doctors, cancer researchers, basic biological scientists, and bioinformaticians to provide integrative insights on tumor microenvironment

Der Klassiker der Intensivmedizin in 13. Auflage!In diesem großen Standardwerk für die Intensivmedizin finden Sie alle Themen der modernen, interdisziplinären Intensivmedizin zusammengetragen. Es bietet höchsten Standard für die ärztliche Weiterbildung und ist gleichzeitig ein wertvolles Nachschlagewerk im klinischen Alltag für Ärztinnen und Ärzte auf Intensivstationen aller Fachrichtungen, u.a. aus Anästhesiologie, Innere Medizin, Chirurgie und Neurologie. Dargestellt werden u.a. moderne Diagnostik, Monitoring - und Therapieverfahren, intensivmedizinisch relevante Krankheitsbilder und Notfälle, Intensivtherapie nach neurochirurgischen, herzchirurgischen, thoraxchirurgischen und abdominalchirurgischen Eingriffen sowie ethische, psychosoziale und pflegerische Aspekte. Weitere Themen sind: Teleintensivmedizin, Weiterbildung und Kompetenzvermittlung in der Intensivmedizin, Langzeitfolgen nach Intensivtherapie, Akut- und Frührehabilitation, Palliativmedizin in der Intensivmedizin, Risikomanagement und Fehlerkultur. Die 13. Auflage erscheint komplett überarbeitet und aktualisiert.

This is an open access book. 2nd Lawang Sewu International Symposium 2023 on Humanities and Social Sciences (LEWIS-HUSO 2023) is an annual international symposium held by Universitas Muhammadiyah Semarang that took place by online format (zoom meeting conference) on 27 November 2023 in Semarang, Central Java, Indonesia.LEWIS-HUSO 2023 is intended to provide a forum for lecturers, professionals, researchers, and students to collaborate, explore opportunities, and exchange valuable insights to shape a sustainable future through cutting-edge innovations and dynamic discourses in technology. Study focused on Humanities and Social sciences are welcome. The submitted papers must meet the criteria including originality, novelty, not yet published, and must be written in English.The conference program will feature main speakers, invitees, and oral sessions. To increase dissemination and visibility of research findings, accepted papers will be published in Atlantis Press Proceedings.

This book offers a comprehensive perspective of herbal medicine phytochemistry and explores the application of plant extracts as bioactive compounds in disease prevention and treatment in modern or traditional medicine. The book starts with an introduction to the history and value of herbal medicine, followed by 3 parts covering the main phytochemical components and metabolites in herbal medicine, different uses and practices in herbal medicine, including a region-wise analysis of methods and practices and an overview of regulations and policies for herbal medicinal practitioners, and the advances and challenges in quality assessment of herbal medicine. Plants generally have the tendency to bioaccumulate trace metals from the environment and they are easily contaminated by microorganisms from water sources and poor hygiene practices of the herbalist. Quality assessment and assurance is, thus, a pertinent challenge in herbal medicine practice (i.e., in remedy formulation and application), and this book offers an authoritative perspective on this topic, covering aspects such as quality control strategies, preparation techniques, chemical quantification in phytomedicine, and the efficacy and safety of herbal remedies. Moreover, in this book, readers will find valuable insights into the latest trends and developments in the field, and a critical review of the application of medicinal plants to treat cardiovascular, digestive, respiratory neurological and reproductive diseases. Particular attention is given to the advances and trends in the field, and readers will learn about the latest biotechnological approaches, the use of nanotechnology in herbal medicine, metabolomic analysis of medicinal plants, big data application in herbal medicine, and the value of herbal medicine towards sustainability. Given its breadth, this book is aimed at researchers, academics, practitioners and professionals working in the fields of natural, life, health, clinical, and biomedical sciences, and interested in herbal remedies, pharmacology, pharmacognosy, human nutrition and dietetics, plant biology, and biotechnology/microbiology.

The most common form of severe dementia, Alzheimer's disease (AD), is a cumulative neurological disorder because of the degradation and death of nerve cells in the brain tissue, intelligence steadily declines and most of its activities are compromised in AD. Before diving into the level of AD diagnosis, it is essential to highlight the fundamental differences between conventional machine learning (ML) and deep learning (DL). This work covers a number of photo-preprocessing approaches that aid in learning because image processing is essential for the diagnosis of AD. The most crucial kind of neural network for computer vision used in medical image processing is called a Convolutional Neural Network (CNN). The proposed study will consider facial characteristics, including expressions and eye movements using the diffusion model, as part of CNN's meticulous approach to Alzheimer's diagnosis. Convolutional neural networks were used in an effort to sense Alzheimer's disease in its early stages using a big collection of pictures of facial expressions.

Cancer cells exist in an ever-changing “ecology” and are subject to evolutionary pressures just like any species in nature. This edited book explores the following themes: 1) how the dynamics of mutation, epigenetics, and gene expression noise are sources of genetic diversity; 2) how scarce resources influence cancer therapy resistance; 3) how predator-prey dynamics are mirrored in immune-cancer cross-talk; 4) how cancer cells parallel niche construction theory; 5) how changing fitness landscapes enable cancer growth; and 6) how cancer cells interact within the body. The book is a resource for understanding cancer as a disease of multicellularity grounded in evolutionary principles. By using this knowledge, researchers are starting to exploit these behaviors for treatment paradigms.Key Features Bridges disciplines exemplifying the ways disparate fields create new perspectives when integrated. Offers insights from leading scholars in cancer biology, ecology and evolutionary biology. Provides a timely recognition by oncologists that evolutionary paradigms are crucial for breakthroughs in cancer treatment. Integrates basic and applied sciences of oncology and evolutionary biology.

The book showcases how the technologies are transforming entertainment, education, and professional training, offering readers real-world examples of their applications.'Innovative Technologies for Enhancing Experiences and Engagement'is an enlightening guide that reveals how emerging technologies are shaping our world, offering insights into the evolving digital landscape and inspiring a future of more personalized, immersive, and engaging experiences.

This book provides the reader with the latest research on vibrational circular dichroism (VCD) spectroscopy including its useful features and applications to many fields. The book starts from an unresolved question in gel chemistry of how component molecules are organized in the flexible fibrils of gels. VCD spectroscopy was successful in giving a clear answer to this mystery. The book also describes a key aspect of this technique lay in the fact that VCD signals were remarkably enhanced when chiral molecules formed a stereoregular molecular array over a few hundred nanometers. VCD spectroscopy was also applied to other topics involving chiral molecules such as the chiral discrimination mechanism in heterogeneous asymmetric catalysis and the build-up of supramolecular chirality in molecular crystals. Furthermore, the book covers the recent instrument developments leading to multi-dimensional VCD measurements with the coordinates of wavenumber, space and time. This progress has opened up new biological and medical applications such as the heterogenous distributions of protein domains in insect wings and the quality control of chiral drugs. The last part of the book presents the possibility of medical diagnosis of Alzheimer's disease through multi-dimensional VCD analyses. This book appeals not only to researchers and students who study spectroscopy but also to ones in catalysis, biology and medicine as users of the VCD methods.

Comprehensive resource summarizing recent research on von Willebrand disease, showing clinicians how to optimize management of patients with this disorder The newly revised and updated second edition of Textbook of von Willebrand Disease: Basic and Clinical Aspects, 2nd edition describes the important and complex role of von Willebrand factor (VWF) in hemostasis and thrombosis, covering not only the current understanding of its molecular biology, but also the association between genetic variants of VWF and different von Willebrand disease (VWD) phenotypes. The text also reviews the important area of the obstetric and gynecological manifestations of VWD, as well as how to manage patients with VWD for surgery. Many advances in agents are included in this updated edition, as well as the wide topics such as VWF in Angiogenesis, and VWF/ADAMTS13 as risk factors of thrombosis. Edited by a team of experts in VWD and an international team of contributors, Textbook of von Willebrand Disease covers sample topics such as: VWF structure and function, biosynthesis and organization of VWF, modulation of VWF by ADAMTS13 and assessment of VWF clearance Clinical, laboratory and molecular markers of different VWD types, from the mild forms of type 1 VWD and the moderate variants types 2A, 2B, 2M, 2N to the most severe type 3 VWD Pediatric aspects of VWD and of women with VWD Management of GI bleeds and appropriate therapies in surgery, and plasma-derived and recombinant VWF concentrates Acquired von Willebrand Syndrome, cardiovascular causes of AVWS, gastrointestinal bleeds in VWD and AVWS, and prophylaxis in von Willebrand disease Providing complete and accessible coverage of the subject, Textbook of von Willebrand Disease: Basic and Clinical Aspects, 2nd edition is a valuable resource for hematologists in practice and in training, along with specialists in thrombosis, hemostasis, and bleeding/clotting disorders.

Organic Reaction Mechanisms 2020, the 56th annual volume in this highly successful and unique series, surveys research on organic reaction mechanisms described in the available literature dated 2020. The following classes of organic reaction mechanisms are comprehensively reviewed: Reaction of Aldehydes and Ketones and their Derivatives Reactions of Carboxylic, Phosphoric, and Sulfonic Acids and their Derivatives Oxidation and Reduction Nucleophilic Aromatic Substitution Electrophilic Aromatic Substitution Carbocations Nucleophilic Aliphatic Substitution Carbanions and Electrophilic Aliphatic Substitution Elimination Reactions Polar Addition Reactions Cycloaddition Reactions Molecular Rearrangements Transition Metal Coupling Radicals An experienced team of authors compile these reviews every year, so that the reader can rely on a continuing quality of selection and presentation.

This book includes 35 vertigo cases, which covers typical cases, difficult cases and rare cases from the department of otorhinolaryngology, neurology, emergency department, geriatrics, ophthalmology, and other disciplines. In each case, it has uniform structure, which includes summary of medical records, case study and case view.This book starts from peripheral vertigo, which is the most common vertigo disease, and belong to vestibular vertigo. It also covers non-vestibular vertigo, which is rare and might be ignored to get timely diagnosis and treatment. In addition, it introduces the patient who have multiple vertigo diseases, which are difficult to diagnosis and treatment, but also easy to be missed or misdiagnosed.This book will be helpful to deeply understand vertigo diseases and improve the diagnosis and treatment of vertigo diseases.The translation was done with the help of artificial intelligence (machine translation by the service DeepL.com). A subsequent human revision was done primarily in terms of content.

Die umfassendste antike Darstellung der Rhetorik findet sich ohne Zweifel in der Institutio oratoria von Quintilian. Obwohl schon viele Wissenschaftlerinnen und Wissenschaftler ihre Forschungen der antiken Rhetorik gewidmet haben, gab es bisher keinen umfangreichen und tiefgehenden Kommentar des 7. Buches von Quintilians Institutio oratoria. Die vorliegende Arbeit schließt diese Forschungslücke. Sie ermöglicht dem/der Leser/-in eine erkenntnisreiche Lektüre, indem ausführliche Informationen zu sprachlichen, textkritischen und inhaltlichen Problemen geboten werden. Die Untersuchung ist in drei Hauptteile gegliedert: (1.) Die Einleitung bietet Erklärungen zu den Hauptthemen der divisio (systematische Gliederung mithilfe von Fragen) sowie der Statuslehre (Einteilung dieser Fragen in Kategorien). (2.) Die Neuedition des Textes stellt die Grundlage für (3.) den Kommentar dar. Jeder, der sich für antike Rhetorik, ihre Argumentationsstruktur, die Welt der Deklamationen und die Kultur der frühen Kaiserzeit interessiert, bekommt mit diesem Buch einen kritischen Begleiter zum Verständnis des von der Forschung eher oberflächlich rezipierten 7. Buches der Institutio oratoria.

Comprehensive Chirality, Second Edition is the definitive ten-volume reference, offering a thorough exploration of chiral research and application. This extensively updated edition features 121 new chapters and 70 revised ones, focusing on the latest advancements in chiral research across synthesis, catalysis, analytical chemistry, and bioactive compound synthesis. Edited by a world-class editorial board, with contributions from leading experts, Comprehensive Chirality, Second Edition bridges theoretical principles with practical applications, making it an invaluable resource for advanced students, researchers, and professionals. Key highlights include:- Innovative Reactions and Methods: advanced diastereo- and enantioselective techniques for controlling stereogenic centers in complex natural products and pharmaceuticals.- Chiral Auxiliaries and Modern Reagents: transformative uses of chiral auxiliaries and cutting-edge reagents such as hypervalent iodide.- Catalytic Methodologies: comprehensive coverage of C-C bond formation, emphasizing transition metals, biocatalysis, and multicatalysis.- Asymmetric Photochemistry: light-induced asymmetric transformations.- Olefin Functionalization and Cycloaddition: asymmetric oxidation and reduction methods.- Biocatalysis and Enzyme Engineering: in-depth analysis of enzyme design and engineering as powerful synthesis catalysts.- Industrial Applications: practical insights into asymmetric synthesis for industrial applications, illustrated through recent case studies.- Spectroscopic Techniques: updated spectroscopic methods for separating and analyzing enantiomers.Unites different areas of research and allows anyone working or researching in chiral chemistry to navigate through the most essential conceptsIncludes different areas of research and deep foundational reviewsHelps users apply context to diverse journal literature, aiding them in identifying areas for further research and/or for solving problemsServes as a valuable, critical tool for instructors, practicing experimentalists, and students of the field, as well as those curious to gain appreciation of the chirality landscape and its vast expanse

The World Today Series: East & Southeast Asia provides historical background on the evolution of Modern East & Southeast Asia to help readers gain a thorough understanding of contemporary developments in this vital region. Broad introductory regional chapters are followed by sections on each country in the region. The combination of factual accuracy and up-to-date detail make this an outstanding resource for researchers, practitioners in international development, media professionals, government officials, potential investors, and students to understand the immediate background of contemporary developments.

Asbestos: Risk Assessment, Epidemiology, and Health Effects offers a key text on the evolving information regarding asbestos and human health. Now in its third edition, this bestseller explores the pathological complexities of asbestos-related disease and examines how asbestos induces diseases in biological systems. The book also discusses the types of instruments and methods available for evaluation of the content of asbestiform minerals in products, air, water, surface areas, and tissue. It explains the relevance of each of these applications and gives readers the tools to evaluate data in the future.Edited by leading authorities on the subject and with contributions from a team of international experts, this book takes a cross-disciplinary approach and an authoritative review of the history, pathology, epidemiology, sampling, and analysis of asbestos. Backed up with photos and numerous diagrams, tables, and photographs, it features case studies, methodologies, and sampling/analytical schemes that put learning into context. Fully up-to-date and featuring four brand new chapters covering asbestosis and immunity, asbestos litigation and surgical and non-surgical management of mesothelioma, this book remains the most comprehensive source of information on asbestos and the only guide the reader will ever need to own.This essential text will appeal to any professional at any level who requires the latest expertise in dealing with asbestos. It suits researchers and practitioners alike, as well as those in the fields of law, health, education, hospitality, emergency response, building management and maintenance, construction, safety, insurance, and industrial hygiene.

This book covers contemporary essays by opinion leaders on crucial topics in dermatology that are not readily available in other textbooks and journals. The essays are written in an unconventional style compared to other textbook styles. Each chapter is authored by a globally renowned expert in that field.The book focuses on artificial intelligence in dermatology, placebo and nocebo in dermatology, mind and skin diseases, unconventional/holistic views on skin aging, evidence-informed dermatology, procedural dermatology, investigative dermatology, lasers and light sources in dermatology, skin in rheumatologic diseases, immunology of the skin, live imaging techniques in dermatology, and so on. The book will help specialists look at the subject from an entirely different perspective and understand how dermatology is evolving in the 21st century. A wide range of dermatology topics is covered, providing a snapshot of contemporary dermatology and the dermatology of the future. It promises to be a delightful journey from basic science to translational science to clinical science. This book will be Intellectually stimulating for dermatology trainees, practitioners, and academicians.

Comprehensive Hematology and Stem Cell Research is the first major reference to cover both stem cell research and therapy as well as the range of hematological disorders they are currently used to treat and may potentially be able to treat in the future. This five volume set includes fundamentals, such as the underlying mechanisms of the blood and immune system, highlighting blood disorders and cancers of the blood, including lymphoma, leukemia, and myeloma. Other sections cover stem cell research and therapy, from harvesting stem cells to their utilization in cancer treatments. Finally, the work looks to the future and explores newer stem cell research that may lead to future treatments. This book is an excellent resource for students at the graduate and post-graduate levels, academics, and researchers in the fields hematology, immunology and oncology.Compiles foundational knowledge and breakthrough research into one concise, comprehensive referenceTakes a translational, bench-to-bedside approach to hematological disorders and stem cell therapiesCovers clinical applications of stem cells, advances in the field, and promising new research

Industrial Applications of Nanoceramics shows the unique processing, mechanical and surface characteristics of nanoceramics, covering their industrial application areas. These include the fabrication of capacitors, dense ceramics, corrosion-resistant coatings, solid electrolytes for fuel cells, sensors, batteries, cosmetic health, thermal barrier coatings, catalysts, bioengineering, automotive engineering, optoelectronics, computers, electronics, etc. This is an important reference source for materials scientists and engineers who are seeking to understand more about how nanoceramics are being used in a variety of industry sectors. Nanoceramics have the ability to show improved and unique properties, compared with conventional bulk ceramic materials. Zirconia (ZrO2), alumina (Al2O3), silicon carbide (SiC), silicon nitride (Si3N4) and titanium carbide fall into this category. Outlines the superior chemical, physical and mechanical properties of nanoceramics compared with their macroscale counterparts Includes major industrial applications of nanoceramics in energy, engineering and biomedicine Explains the major processing techniques used for nanoceramic-based materials

The New Era of Precision Medicine: What it Means for Patients and the Future of Healthcare highlights aspects of precision medicine in different specialties and offers an understanding of how a biological background integrates into clinical guidelines, the therapeutic efficacy of interventions and disease prevention. The book explains how precision healthcare differs among countries, as well as how there is a collaboration among many labs to share resources and knowledge to advance the field across the globe. The book also discusses the cultural differences and cultural sensitivity that may be involved in the precision medicine approach. Finally, with regard to safety and quality outcomes, the book presents a range of current and possible future concerns related to those outcomes. Precision medicine is the new standard of quality healthcare delivery. It aims to optimize patient safety and clinical outcomes, enhance the efficacy of therapeutic interventions, and facilitate disease prevention, offering a way to customize patient care, decision-making, and clinical practice.Highlights the characteristics of precision medicine in different areasOffers an understanding of how a biological background integrates into clinical guidelines, the therapeutic efficacy of interventions, and disease preventionEmphasizes how medicine has transformed from a “one-size-fits-all” approach to personalized medicine influenced by individual characteristicsIntroduces complex topics delivered in terms that target a broad range of audiences

Colorectal surgery has been evolving rapidly over recent years and the COVID pandemic has necessitated a critical approach to all aspects of care. This book offers an up-to-date appraisal of the increasingly used neoadjuvant therapy. In many situations a multidisciplinary approach is taken to achieve high quality and successful outcomes. In addition, topics such as the management of the open abdomen, complex abdominal wall reconstruction, artificial intelligence and modern management of inflammatory bowel disease are covered. Written by experts in their field, this book is of interest to both trainees and practicing surgeons in coloproctology.

This book provides a comprehensive overview of essential concepts and evidence that guide the practice of contemporary preventive cardiovascular nursing. The sections incorporate a lifespan approach to cardiovascular wellness, and provide perspectives on sources of known and emerging cardiovascular risk factors as well as the spectrum of multidimensional factors including biological, behavioral, psychological and sociocultural influences on cardiovascular wellness, risk, and the evolution of cardiovascular conditions. Unique features address: 1) building resilience across the lifespan such that optimal cardiovascular wellness can be attained within multiple contexts of health states to increase a healthy lifespan and longevity; 2) behavior change skills for risk factor reduction; 3) risk factors and risk reduction approaches with special populations defined by gender,, age and aging, heath states, and health equity issues; and 4) high level roles for cardiovascular nurses as provider - risk assessor, communicator and care provider; educator, leader, patient and health advocate. Relevant case studies are included throughout to facilitate the application of the content. This book fills a gap in that there is no other book on preventive cardiovascular nursing care and roles, and it provides support for the nurse to lead relevant interdisciplinary teams. The book will empower nurses to build knowledge and skills for cardiovascular prevention and to provide leadership for optimal cardiovascular wellness for patients and communities.

VETERINARY ANESTHESIA AND ANALGESIA A thoroughly updated new edition of the foundational reference on veterinary anesthesia and analgesia Veterinary Anesthesia and Analgesia: The Sixth Edition of Lumb and Jones is a fully updated revision to this comprehensive, authoritative reference to all aspects of veterinary anesthesia and pain management. Encompassing both scientific principles and clinical applications, the new edition adds new knowledge, techniques, and discussion of emerging issues throughout. Fourteen new chapters significantly expand the coverage of patient monitoring modalities and nociception and pain, while presenting new information on safety culture, infection prevention and control, biomedical engineering, and point-of-care ultrasound. Logically organized into sections, information on basic principles, pharmacology, specific body systems, and specific species is easy to access. Comparative anesthetic considerations for dogs and cats, horses, ruminants, swine, laboratory animals, free-ranging terrestrial mammals, marine mammals, reptiles, amphibians, fish, and birds are discussed. Chapters are devoted to anesthesia and pain management of common domestic species and patient populations, including updated chapters on local and regional anesthetic and analgesic techniques. A companion website offers video clips of point-of-care ultrasound techniques and pain assessment and scoring. Readers of Veterinary Anesthesia and Analgesia: The Sixth Edition of Lumb and Jones will also find: Significantly expanded coverage of patient monitoring, including new chapters devoted to anesthetic depth and electroencephalography, electrocardiography, blood pressure, ventilation, oxygenation, and anesthetic gas monitoring. More in-depth coverage of respiratory physiology and pathophysiology, with new sections covering oxygen therapy, mechanical ventilation, anesthetic management considerations for bronchoscopy, intrathoracic procedures, including one-lung ventilation, and patients with respiratory disease. Expanded coverage of pain physiology and pathophysiology, recognition and quantification of pain, and clinical pain management, including both pharmacologic and nonpharmacologic modalities. A companion website incorporating video clips and example pain scoring sheets to complement the more than 500 images in the text itself. With its unparalleled multidisciplinary approach, Veterinary Anesthesia and Analgesia is a must-own volume for veterinary anesthesia specialists and researchers; specialists in other disciplines, including both small and large animal surgeons; practitioners; and students.

This new edition of an established resource provides an extensive look at the practical management, both medical and surgical, of all forms of hair loss. Proper examination of the patient with hair loss is discussed in depth, as is androgenetic alopecia, the most common cause of hair loss. The autoimmune disease alopecia areata is examined comprehensively, including its pathogenesis, clinical features, differential diagnosis, and treatment. This edition also covers the latest developments in the diagnosis and treatment of the disease, along with hair restoration surgery.This compact and easy-to-read book remains a valuable resource for professional training and use.‘This book… has added value to my aesthetic practice and … allowed me to be better for my patients'—PMFA, of the second editionKey Features: Presents an authoritative guide for diagnosis and treatment Offers the dermatologist and plastic surgeon a comprehensive survey of the possible options and results Remains the established leader in the topic

Il recente libro di Lorenzo Tomasin, Europa Romanza (2021), ha avuto il merito rinnovare gli studi sul contatto linguistico, privilegiando testi di consumo e scritti di carattere privato (realizzati tra Medioevo e Rinascimento) in cui si faceva prova di un più o meno consapevole plurilinguismo. Tomasin ha contribuito a «inquadrare il multilinguismo della società e il plurilinguismo degli individui come caratteri fondanti della cultura europea nel suo insieme». Convergenze plurilingui ha raccolto da Europa Romanza l'invito a riflettere su una «costituzione della coscienza linguistica attraverso il confronto e l'incrocio delle esperienze culturali». I lavori di questo volume continuano infatti, idealmente, le sette storie raccontate da Tomasin, tentando di contribuire alla definizione del fenomeno plurilingue. Il plurilinguismo, inteso come intersezione tra diversi volgari o diverse varianti di una stessa lingua, si rivela essere il segno di una funzione culturale e, in alcuni casi, anche una marca di genere testuale. Questo volume è dunque destinato ai linguisti interessati tanto alla formazione delle lingue in contesto europeo quanto al plurilinguismo in chiave storica.

HIV-Associated Neurocognitive Disorders: Molecular and Cellular Mechanisms and Clinical Manifestations is a comprehensive volume on the field of HIV-Associated Neurocognitive Disorders (HAND) as well as its associated comorbidities. Covering clinical manifestations as well as molecular and cellular mechanisms, this book discusses available macaque and rodent animal models of HAND, epigenetic regulation, and signaling pathways underlying symptoms. Chapters also cover prevention and therapeutic strategies, as well as diagnosis and biomarkers associated with disease outcomes. This volume is appropriate for basic research and clinical investigators working in the area of HIV-1 infection.Provides an in-depth exploration of the clinical manifestations of HAND and its comorbiditiesIncludes detailed assessments of the molecular and cellular mechanisms underlying HAND symptomsExamines animal models for studying HAND, including macaque and rodent modelsPresents insights into epigenetic regulation and signaling pathways implicated in HANDCovers prevention, therapeutic strategies, and diagnostic approaches