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This book is to elucidate personal and social bases for personal resilience, thus addressing the issue concerning the predominance of social factors in shaping resilience. Essentially, the book starts with a clarification of resilience as a phenomenon rather than a trait. The clarification also identifies the personal bases in terms of the resilience process, which specifies belief about resilience as a precursor to learning about resilience, action for resilience, and resilience successively. To justify the personal and social bases, the book expounds the analytical-functionalist framework to specify voluntaristic and deterministic mechanisms to perform the four requisite functions of goal attainment, adaptation, integration, and latency. Equipped with the conceptual and theoretical grounds, the book proceeds to scrutinize the effects of personal and social factors on resilience and its process. The personal factors include personal background characteristics, personality, functional disability, and various beliefs, whereas the social factors include experiences of caring, peace, violence, and social exclusion in society, kindness, sociability, and aid from other people, and social capital. The scrutiny engages five databases about 6.948 Chinese people in Hong Kong and neighboring Chinese cities, composed of the public, service users, older adults, students, and people with visual impairment. Overall, the book presents ample theoretical and empirical substances to clarify the genesis of resilience.

The 12-volume set LNCS 15001 - 15012 constitutes the proceedings of the 27th International Conferenc on Medical Image Computing and Computer Assisted Intervention, MICCAI 2024, which took place in Marrakesh, Morocco, during October 6–10, 2024. MICCAI accepted 857 full papers from 2781 submissions. They focus on neuroimaging; image registration; computational pathology; computer aided diagnosis, treatment response, and outcome prediction; image guided intervention; visualization; surgical planning, and surgical data science; image reconstruction; image segmentation; machine learning; etc.

The six-volume set LNCS 14608, 14609, 14609, 14610, 14611, 14612 and 14613 constitutes the refereed proceedings of the 46th European Conference on IR Research, ECIR 2024, held in Glasgow, UK, during March 24–28, 2024.The 57 full papers, 18 finding papers, 36 short papers, 26 IR4Good papers, 18 demonstration papers, 9 reproducibility papers, 8 doctoral consortium papers, and 15 invited CLEF papers were carefully reviewed and selected from 578 submissions. The accepted papers cover the state of the art in information retrieval focusing on user aspects, system and foundational aspects, machine learning, applications, evaluation, new social and technical challenges, and other topics of direct or indirect relevance to search.

This book presents the select proceedings of the 3rd International Conference on Mechanical and Energy Technologies (ICMET 2023). It covers a wide range of topics, including robotics and automation, advanced manufacturing technologies, materials science and engineering, thermodynamics, fluid mechanics, automotive engineering, and interdisciplinary areas such as the application of computer science and electronics in mechanical engineering. This is a useful resource for researchers and professionals in mechanical engineering.

This book constitutes the proceedings of the 9th International Conference on Digital Economy, ICDEc 2024, held in Rabat, Morocco, during May 9-11, 2024. The 43 full papers were carefully reviewed and selected from 117 submissions. They were categorized under the topical sections as follows: Part I: Digital Transformation, Digital Economy and Investment, Artificial Intelligence and E-learning, E-commerce and Social Media Marketing, Exploring the Nexus of Digital and Sustainable Economies in Developing States and Digital Business Models. Part II: Application of Machine Learning for Business, Digital Technologies and Innovative Management, Social Networks and Information Technologies, Digital Economy in Emerging Countries Mobile Banking and Digital Assets, Online Session.

This book reviews the latest developments and applications in the field of biosensing, providing readers with an update of the earlier, successful edition, Biosensing for the 21st Century. In this book, readers will find comprehensive key information on the advances and challenges in biorecognition elements and transduction principles, including examples of new materials and new methods. Ranging from engineering chimeric enzymes to the progress in electrochemical sensing of drugs, the book discusses the latest innovations in the field and thus, provides the reader with a profound overview. In the field of biological recognition the focus will be on switchable sensors by engineering new proteins, the development of Molecular Imprinted Polymers (MIPs) for proteins or even larger biological entities, the construction of complex nucleic acid – protein structures for affinity sensing and the application of whole microbes. The book covers new trends in signal transduction which includes graphene-based field effect transistors, nanopores designed for high selectivity and sensitivity in analysis, plasmonic and nanophotonic sensing applying metal nanostructures up to new developments in microarray construction. An introduction in to the challenges in skin-interfaced systems for continuous biochemical sensing, offers a glimpse into the future of wearable technologies. Furthermore, actual areas of application of new sensing strategies such as the detection of various types of viruses and bacteria or the analysis of drugs will be highlighted. Each chapter provides a scholarly yet accessible perspective on the latest trends in biosensor technology. Given its breadth, the book has an interdisciplinary appeal and engages a wide readership, from students and researchers to practitioners in academia and industry, interested in the fields of biochemical/biomedical engineering and in biosensing methodologies and applications.

This book constitutes the proceedings of the 15th IFIP WG 8.5 International Conference on Electronic Participation, ePart 2023, held in Budapest, Hungary, in September 2023, in conjunction with the IFIP WG 8.5 Conference on Electronic Government (EGOV 2023) and the Conference for E-Democracy and Open Government Conference (CeDEM 2023). A total of 38 full papers has been carefully reviewed and selected from 106 submissions. Eight of the accepted papers are included in this book. They were organized in topical sections as follows: E-participation; digital transformation; digital technology; and digital sovereignty.

Das Standardwerk der Andrologie - jetzt komplett aktualisiert! Das Buch gibt einen vollständigen, interdisziplinären Überblick aller Themen der Andrologie, u.a. · der Infertilität, · des Hypogonadismus, · der männlichen Kontrazeption, · der erektilen Dysfunktion und · der Varianten der sexuellen Differenzierung. Der Leser erhält detaillierte Informationen über · die Physiologie der Hoden- und Spermienfunktion · die Diagnostik und Therapie einschl. operativer Verfahren in der Andrologie · die klinische Praxis der Paarbehandlung, · relevante Fakten aus der Gynäkologie, · moderne Verfahren der assistierten Fertilisation · psychologische Faktoren der Sexualität und Infertilität · Umwelteinflüsse auf die Fertilität · Therapie mit Testosteron und Missbrauch · endokrinologische und reproduktive Funktionen des alternden Mannes. · Fertilitätsprotektion · rechtliche und ethische Grundlagen der Andrologie Zusätzlich werden die relevanten naturwissenschaftlichen Grundlagen – einschließlich Molekularbiologie und -genetik – abgedeckt. Komplett nach dem neuesten Stand der wissenschaftlichen Erkenntnis überarbeitet, aktualisiert und praxisorientiert ist der Nieschlag das Standardwerk der Andrologie, an dem keine Ärztin und kein Arzt, der sich mit dem Thema befasst, vorbeikommt. Für Andrologen und Teilnehmer der Zusatzbezeichnung'Andrologie', Urologen, Dermatologen und Internisten, die sich mit dem Gebiet Andrologie beschäftigen. Für Reproduktionsbiologen und Reproduktionsmediziner mit Interesse an der Paarbehandlung.

This book constitutes the refereed proceedings of the 4th Southern African Conference on Artificial Intelligence Research, SACAIR 2023, held in Muildersdrift, South Africa, in December 2023. The 22 full papers presented in these proceedings were carefully reviewed and selected from 66 submissions. The papers are organized in the following topical sections: Responsible and Ethical AI Track; Socio-Technical and Human-Centered AI Track; Algorithmic, and Data Driven and Symbolic AI.

The successful book of andrology now in a new edition! This book gives a complete, interdisciplinary overview of the central topics of andrology, infertility, hypogonadism, contraception and erectile dysfunction. It contains detailed information on the clinical practice of couple treatment, andrology-relevant gynecology and modern methods of assisted fertilization, psychological factors of infertility, endocrinology and reproductive functions of the aging man as well as on an important sub-area of ​​andrology, the male contribution to contraception. In addition, the relevant scientific foundations (including molecular biology and genetics) are also covered. Completely revised and updated according to the latest scientific research, the new edition represents a reference for andrology, which no doctor who deals with the topic can miss. For andrologists, practitioners and residents, urologists, dermatologists and internists who deal with the area of​​andrology and male reproductive medicine.

This book features selected papers presented at the 20th International Conference on Near Infrared Spectroscopy. It discusses the latest progress in the field of near infrared spectroscopy from around the globe, including the advances in instrumentation, spectral interpretation and Chemometrics. In addition, it presents potential trends for near infrared spectroscopy in the next decade and highlights developments in process analytical technology, chemical imaging and deep learning. It can be used as a reference book for researchers and application personnel engaged in spectroscopy technology, Chemometrics, analytical instruments, on-site rapid or on-line analysis, process control and other fields. It will also be useful for undergraduates and postgraduates studying these topics.

Thermomechanics & Infrared Imaging, Inverse Problem Methodologies and Mechanics of Additive & Advanced Manufactured Materials, and Advancement of Optical Methods & Digital Image Correlation, Volume 4 of the Proceedings of the 2021 SEM Annual Conference & Exposition on Experimental and Applied Mechanics, the fourth volume of four from the Conference, brings together contributions to this important area of research and engineering. The collection presents early findings and case studies on a wide range of areas, including: Test Design and Inverse Method Algorithms Inverse Problems: Virtual Fields Method Material Characterizations Using Thermography Fatigue, Damage & Fracture Evaluation Using Infrared Thermography Mechanics of Additive & Advanced Manufactured Materials DIC Methods & Its Applications Photoelasticity and Interferometry Applications Micro-Optics and Microscopic Systems Multiscale and New Developments in Optical Methods

Panic buying is a common response during crises; however, to date it has been a significantly under-researched area. Recent evidence suggests that an environmental stimulus, such as the COVID-19 pandemic, war, earthquakes, flooding, public health emergencies (SARS, MARS) can trigger this phenomenon. As an environmental crisis takes its toll, the understanding of panic buying becomes overlooked. Nevertheless, panic buying causes series of events separate from these primary events. Understanding the management of emergencies and disasters should be an integral part of dealing with panic buying since every major environmental crisis has the potential to initiate panic buying behaviour in the general public. This book will analyse episodes of panic buying and major environmental crisis focusing on specific prevention strategies. This book is the first of its kind of approach to join up the management of panic buying during a public health emergency.

This book showcases a wealth of knowledge and insight on gender and sexuality development. With contributions from leading researchers, it covers a comprehensive set of topics at the forefront of the field and strikes a balance between traditional and emerging areas of study. Given that gender and sexuality are shaped by myriad influences, this book is modelled on an interdisciplinary perspective and delves into biological, comparative, psychological, cognitive, social, cultural, and clinical approaches. In so doing, this collection conveys the rich tapestry of gender and sexuality science and will hold value for many. For those already in the field, this book provides an excellent resource for brushing up on the latest and for inspiring the next phases of scientific investigation. Those who are newer to the field, including undergraduate and graduate students, stand to gain tremendously from not only the thoughtful and informative content, but also from the interdisciplinary approachmodelled throughout the book. Beyond academia, this book is a valuable resource for clinicians and policy makers who deal with child and adolescent issues.

Bioactive compounds in food, known for their positive health effects, can be lost during handling after harvest, processing and storage. While most foods are exposed to processing to increase shelf life and edibility and to ensure microbial safety, conventional processing methods may have disadvantages, such as decreasing the nutritional quality of foods, long processing times, high temperature and high energy uses. For these reasons, novel non-thermal food processing technologies (including HPP, ultrasound) and novel thermal food processing technologies (including microwave/Ohmic heating) have become widespread.This book provides a critical evaluation of the effects of conventional, novel non-thermal, and thermal food processing techniques on the retention and bioaccessibility of bioactive compounds in food materials. Within these three categories, many different processing methods are included: fermentation/germination, drying, extrusion, and modified atmosphere packaging, as well as novel technologies, such as microwave heating, ultrasound, high pressure processing, ozonation, and membrane separation processes.

This reference book, which is the second volume of Targeting Oxidative Stress in Cancer, explores oxidative stress as the potential therapeutic target for cancer therapy. The initial chapters discuss the molecular mechanisms of oxidative stress and its effects on different signaling pathways. Subsequently, the sections examine the impact of redox signaling on tumor cell proliferation and consider the therapeutic potential of dietary phytochemicals and nutraceuticals in reactive oxygen species (ROS)-induced cancer. In turn, it examines the evidence supporting the use of Vitamin C in cancer management, before presenting various synthetic and natural compounds that have therapeutic implications for oxidative stress-induced cancer. It also explores the correlation between non-coding RNA and oxidative stress. Furthermore, the book summarizes the role of stem cells in ROS-induced cancer therapy and reviews the therapeutic applications of nanoparticles to alter redox haemostasis in cancer cells. Lastly, it explores heat-shock proteins, ubiquitin ligases, and probiotics as potential therapeutic agents in ROS-mediated cancer. This book is a useful resource for basic and translational scientists as well as clinicians interested in the field of oxidative stress and cancer therapy. ​

This pocket guide provides a concise yet comprehensive overview of the two most prominent clinical features of multiple myeloma (MM), bone disease and renal failure. The first half of the text reviews critical aspects of bone disease in MM, including pathophysiology, the use of imaging modalities and drugs in treatment, and the role of orthopedic surgery. The latter half of the book reviews major components of kidney disease in MM, from pathophysiology to treatment. Written by experts in the field, Management of Bone Disease and Kidney Failure in Multiple Myeloma: A Pocket Guide is a valuable resource for clinicians and practitioners who manage patients afflicted with multiple myeloma.

This book constitutes the proceedings of the 19th International Symposium on Intelligent Data Analysis, IDA 2021, which was planned to take place in Porto, Portugal. Due to the COVID-19 pandemic the conference was held online during April 26-28, 2021.The 35 papers included in this book were carefully reviewed and selected from 113 submissions. The papers were organized in topical sections named: modeling with neural networks; modeling with statistical learning; modeling language and graphs; and modeling special data formats.

Challenges in Mechanics of Time-Dependent Materials, Volume 2 of the Proceedings of the 2020 SEM Annual Conference& Exposition on Experimental and Applied Mechanics, the second volume of seven from the Conference, brings together contributions to this important area of research and engineering. The collection presents early findings and case studies on fundamental and applied aspects of Experimental Mechanics, including papers in the following general technical research areas: Characterization Across Length ScalesExtreme Environments & Environmental EffectsSoft MaterialsDamage, fatigue and FractureInhomogeneities & InterfacesViscoelasticityResearch in Progress

Challenges in Mechanics of Time-Dependent Materials, Mechanics of Biological Systems and Materials, and Micro-and Nanomechanics, Volume 2 of the Proceedings of the 2021 SEM Annual Conference & Exposition on Experimental and Applied Mechanics, the second volume of four from the Conference, brings together contributions to this important area of research and engineering. The collection presents early findings and case studies on fundamental and applied aspects of Experimental Mechanics, including papers in the following general technical research areas: Characterization Across Length Scales Extreme Conditions & Environmental Effects Damage, Fatigue and Fracture Structure, Function and Performance Rate Effects in Elastomers Viscoelasticity & Viscoplasticity Research in Progress Extreme Nanomechanics In-Situ Nanomechanics Expanding Boundaries in Metrology Micro and Nanoscale Deformation MEMS for Actuation, Sensing and Characterization 1D & 2D Materials Cardiac Mechanics Cell Mechanics Biofilms and Microbe Mechanics Traumatic Brain Injury Orthopedic Biomechanics Ligaments and Soft Materials

Humans have a unique ability to understand the beliefs, emotions, and intentions of others—a capacity often referred to as mentalizing. Much research in psychology and neuroscience has focused on delineating the mechanisms of mentalizing, and examining the role of mentalizing processes in other domains of cognitive and affective functioning. The purpose of the book is to provide a comprehensive overview of the current research on the mechanisms of mentalizing at the neural, algorithmic, and computational levels of analysis.The book includes contributions from prominent researchers in the field of social-cognitive and affective neuroscience, as well as from related disciplines (e.g., cognitive, social, developmental and clinical psychology, psychiatry, philosophy, primatology). The contributors review their latest research in order to compile an authoritative source of knowledge on the psychological and brain bases of the unique human capacity to think about the mental states of others. The intended audience is researchers and students in the fields of social-cognitive and affective neuroscience and related disciplines such as neuroeconomics, cognitive neuroscience, developmental neuroscience, social cognition, social psychology, developmental psychology, cognitive psychology, and affective science. Secondary audiences include researchers in decision science (economics, judgment and decision-making), philosophy of mind, and psychiatry.

This book reviews the current state of epigenetics and proteomics of leukemia and introduces the methods that are important to process and evaluate these factors in leukemia. In particular, epigenetic modifiers and their inhibitors in leukemia treatment as well as approaches to the epigenetic treatment of leukemia are covered. Various computational methods for proteome analysis are also described in detail, including 2DE fractionation and visualization, proteomic data processing, image acquisition and data anlaysis, and more. Protein localization in leukemia is also covered, in addition to the future of leukemia therapy. Epigenetics and Proteomics of Leukemia is an ideal book for advanced biomedical scientists and students, medical doctors and students, bioinformatics and health informatics researchers, computational biologists, structural biologists, systems biologists, and bioengineers.

This book provides in-depth coverage of all aspects of pelvic ring fractures and their management. The opening chapters supply essential information on surgical anatomy, biomechanics, classification, clinical evaluation, radiological diagnostics, and emergency and acute management. The various operative techniques, including navigation techniques, that have been established and standardized over the past two decades are then presented in a step-by-step approach. Readers will find guidance on surgical indications, choice of approaches, reduction and fixation strategies, complication management, and optimization of long-term results. Specific treatment concepts are described for age-specific fractures, including pediatric and geriatric injuries, and secondary reconstructions. Pelvic ring fractures represent challenging injuries, especially when they present with concomitant hemodynamic instability. This book will help trauma and orthopaedic surgeons at all levels of experience to achieve the primary treatment aim of anatomic restoration of the bony pelvis to preserve biomechanical stability and avoid malunion with resulting clinical impairments.

This text provides a comprehensive, state-of-the-art overview of the diagnosis and management of the critically ill cirrhotic patient. The book reviews recent data about risk factors for acute on chronic liver failure (including infection, renal dysfunction and acute alcoholic hepatitis), profiles the latest treatment strategies for the management of variceal bleeding, ascites, hepatocellular carcinoma and presents current and novel therapies for acute hepatic encephalopathy, and anticoagulation in liver disease. The volume also focuses on the changing etiology of liver disease, with an emphasis on obesity and frailty/sarcopenia, and advances in surgical techniques, including living donor liver transplants and gender disparities in liver transplantation. Palliative care for the critically ill liver patient is also discussed in the book.Written by experts in the field, The Critically Ill Cirrhotic Patient: Evaluation and Management is a valuable resource for clinicians, practitioners, health care providers, and researchers who encounter patients with chronic liver disease, including end-stage liver cirrhosis.

The book presents research that contributes to the development of intelligent dialog systems to simplify diverse aspects of everyday life, such as medical diagnosis and entertainment. Covering major thematic areas: machine learning and artificial neural networks; algorithms and models; and social and biometric data for applications in human–computer interfaces, it discusses processing of audio-visual signals for the detection of user-perceived states, the latest scientific discoveries in processing verbal (lexicon, syntax, and pragmatics), auditory (voice, intonation, vocal expressions) and visual signals (gestures, body language, facial expressions), as well as algorithms for detecting communication disorders, remote health-status monitoring, sentiment and affect analysis, social behaviors and engagement. Further, it examines neural and machine learning algorithms for the implementation of advanced telecommunication systems, communication with people with special needs, emotionmodulation by computer contents, advanced sensors for tracking changes in real-life and automatic systems, as well as the development of advanced human–computer interfaces. The book does not focus on solving a particular problem, but instead describes the results of research that has positive effects in different fields and applications.

This book provides essential information on the status quo and changing profile of Hirschsprung's disease and allied disorders. Hirschsprung's disease is a common cause of neonatal intestinal obstruction and one of the most important and most fascinating diseases in pediatric surgery throughout the world. Currently, the diagnosis and treatment of Hirschsprung's disease and allied disorders are in a state of constant development. Written by expert pediatric surgeons, Hirschsprung's Disease and the Allied Disorders presents state-of-the-art information, such as new genetic evidence, and historical operative techniques that were less invasive and resulted in fewer follow-up operations. It offers a highly informative guide that will greatly benefit all readers engaged in pediatric medicine, pediatric surgeons, and the medical staff of NICUs around the globe.

This book is the first to provide balanced examination of both pediatric liver disease and liver transplantation – two topics that are inherently related, given that most chronic liver disorders eventually require organ replacement. The different forms of liver disease encountered in the pediatric age group are first discussed in a series of disease-specific chapters that have a reader-friendly, uniform structure covering pathophysiology, diagnostic and treatment algorithms, clinical cases, and transition to adult care. Key topics in the field of liver transplantation are then addressed. Examples include indications and contraindications, surgical techniques and complications, immunosuppression, in pediatric liver transplantation, acute and chronic rejection and allograft dysfunction, and CMV and EBV infection in transplant recipients, long-term graft injury and tolerance. A section on pediatric hepatology across the world includes chapters presenting the features and management of pediatric liver disease in South-America, Africa and Asia. A closing section considers what the future holds for pediatric liver disease and its management, including novel genetic testing, cell therapy and gene therapy. Pediatric Hepatology and Liver Transplantation will be of value for a range of practitioners, from residents making their first approach to pediatric liver disease through to specialists working in transplantation centers.

This book discusses the current research concepts and the emerging technologies in the field of stem cells and tissue engineering. It is the first authoritative reference documenting all the ways that plastic surgical practice and regenerative medicine science overlap or provide a road map for the future of both specialties. The Editors have provided a valuable service by gathering in one place the leading voices in these two fields in clear and concise manner. Divided into five parts, the book opens with a description of the elements of regenerative medicine including definitions, basic principles of soft and bone tissue regeneration, biomaterials and scaffolds. Current research concepts are explored in the second part of this book, for example mechanotransduction and the utility of extracellular vesicles. In the third part, the editors present the emerging technologies and highlight the novel perspectives on bionic reconstruction and biomimetics in surgery and regenerative medicine. Part four deals with translational aspects including practical information on moving scientific findings from bench to bedside. The final part then describes in detail applications in clinical plastic surgery. Written by leading experts this book is an invaluable resource for researchers, students, beginners and experienced clinicians in a range of specialties.'In your hands is a comprehensive encyclopedia of two rapidly converging fields. Drs Duscher and Shiffman have done an outstanding job of highlighting the interdependent relationship between plastic surgery and regenerative medicine. Ultimately, this is to the benefit of both fields.'- Geoffrey C. Gurtner, MD, FACS Johnson and Johnson Distinguished Professor of Surgery Professor (by courtesy) of Bioengineering and Materials Science Inaugural Vice Chairman of Surgery for Innovation Stanford University School of Medicine

This book comprehensively covers the latest developments in the diagnosis and treatment of liver cirrhosis, including molecular mechanisms and therapeutic strategies. It elaborates on and explores the relation between chronic liver disease (CLD) and its causes, including viral hepatitis, steatohepatitis, autoimmune liver diseases and/or inherited liver diseases, and sustained liver injury. Furthermore, it discusses various complications such as hepatic encephalopathy, ascites, sarcopenia, esophagogastric varices, muscle cramps and pruritus, and the fact that it frequently leads to the development of hepatocellular carcinoma. CLD is becoming a growing issue with substantial effects on public health, and Evolving Landscape in Management of Liver Cirrhosis provides scholars in gastroenterology and hepatology with invaluable insights. At the same time, it is a valuable resource for clinicians specializing in gastroenterology and hepatology as well as for researchers who are curious about new research on liver disease.

This book provides a concise yet comprehensive overview of frailty and sarcopenia in the cirrhotic patient. The text presents a personalized approach to identifying cirrhotic patients at risk of higher morbidity and mortality due to frailty and sarcopenia. It reviews current and novel diagnostic methods, while spotlighting treatment and management strategies for frailty and sarcopenia. The book also focuses on special issues associated with these syndromes, such as the effect of gender, age, and ethnicity on frailty and sarcopenia, sarcopenic obesity, and frailty and sarcopenia after liver transplantation. Future considerations are outlined in the closing chapters, including emerging pharmacological and interventional therapies for these syndromes.Written by experts in the field, Frailty and Sarcopenia in Cirrhosis: The Basics, the Challenges, and the Future is a valuable resource for clinicians and practitioners who treatpatients with cirrhosis.

This book reviews the chemical, regulatory, and physiological mechanisms of protein arginine and lysine methyltransferases, as well as nucleic acid methylations and methylating enzymes. Protein and nucleic acid methylation play key and diverse roles in cellular signalling and regulating macromolecular cell functions.Protein arginine and lysine methyltransferases are the predominant enzymes that catalyse S-adenosylmethionine (SAM)-dependent methylation of protein substrates. These enzymes catalyse a nucleophilic substitution of a methyl group to an arginine or lysine side chain nitrogen (N) atom. Cells also have additional protein methyltransferases, which target other amino acids in peptidyl side chains or N-termini and C-termini, such as glutamate, glutamine, and histidine. All these protein methyltransferases use a similar mechanism. In contrast, nucleic acids (DNA and RNA) are substrates for methylating enzymes, which employ various chemical mechanisms to methylatenucleosides at nitrogen (N), oxygen (O), and carbon (C) atoms. This book illustrates how, thanks to there ability to expand their repertoire of functions to the modified substrates, protein and nucleic acid methylation processes play a key role in cells.

Dynamic Behavior of Materials, Volume 1 of the Proceedings of the 2017 SEM Annual Conference& Exposition on Experimental and Applied Mechanics, the first volume of nine from the Conference, brings together contributions to this important area of research and engineering. The collection presents early findings and case studies on fundamental and applied aspects of Experimental Mechanics, including papers on: Quantitative VisualizationFracture & FragmentationDynamic Behavior of Low Impedance MaterialsShock & BlastDynamic Behavior of CompositesNovel Testing TechniquesHybrid Experimental & Computational MethodsDynamic Behavior of Geo-materialsGeneral Material Behavior

This third edition provides translations of all chapters of the most recent fifth German edition of Motivation and Action, including several entirely new chapters. It provides comprehensive coverage of the history of motivation, and introduces up-to-date theories and new research findings. Early sections provide a broad introduction to, and deep understanding of, the field of motivation psychology, mapping out different perspectives and research traditions. Subsequent chapters examine major themes of human motivation, including achievement, affiliation, and power motivation as well as the fundamentals of motivation psychology, such as motivated and goal oriented behaviors, implicit and explicit motives, and the regulation of development. In addition, the book discusses the roles of motivation in three practical fields: school and college, the workplace, and sports. Topics featured in this text include: Social Relationshipsand its effects on sexual or intimacy motivation. Conscious and unconscious motivators of behavior.Drives and incentives in the fields of achievement, intimacy, sociability and power.How the biochemistry and structures of our brain shapes motivated behavior.How to engage in intentional goal-directed behavior.The potential and limits of motivation and self-direction in shaping our lives.Motivation and Action, Third Edition, is a must-have resource for undergraduate and graduate students as well as researchers in the fields of motivation psychology, cognitive psychology, and social psychology, as well as personality psychology and agency. About the Editor: Jutta Heckhausen is the daughter of Heinz Heckhausen, who published'Motivation and Action” as a monograph in 1980 and who died in 1988 just before the 2nd edition came out. Dr. Heckhausen received her Ph.D. in 1985 from the University of Strathclyde, Glasgow with a dissertation about early mother-child interaction, and did her Habilitation in 1996 at the Free University of Berlin with a monograph about developmental regulation in adulthood. Dr. Heckhausen worked for many years at the Max Planck Institute for Human Development in Berlin, conducting research about the role of motivation in lifespan development. She is currently a professor of psychology at the University of California, Irvine.

This unique reference explores the processes and nuances of human habits through social psychology and behavioral lenses. It provides a robust definition and theoretical framework for habit as well as up-to-date information on habit measurement, addressing such questions as which mechanisms are involved in habitual action and whether people can report accurately on their own habits. Specialized chapters pay close attention to how habits can be modified, as well as widely varying manifestations of habitual thoughts and behaviors, including the mechanisms of drug addiction and recovery, the repetitive characteristics of autism, and the unwitting habits of health professionals that may impede patient care. And across these pages, contributors show the potential for using the processes of maladaptive habits to replace them with positive and health-promoting ones. Throughout this volume attention is also paid to the practice of conducting habit research. Among the topics covered: Habit mechanisms and behavioral complexity.Complexities and controversies of physical activity habit.Habit discontinuities as vehicles for behavior change.Habits in depression: understanding and intervention.A critical review of habit theory of drug dependence.Questions about the automaticity of habitual behaviors. The Psychology of Habit will interest psychologists across a wide spectrum of domains: habit researchers in broader areas of social and health psychology, professionals working in (sub)clinical areas, interested scholars in marketing, consumer research, communication, and education, and public policymakers dealing with questions of behavioral change in the areas of health, sustainability, and/or education.

This book focuses on numerical simulations of manufacturing processes, discussing the use of numerical simulation techniques for design and analysis of the components and the manufacturing systems. Experimental studies on manufacturing processes are costly, time consuming and limited to the facilities available. Numerical simulations can help study the process at a faster rate and for a wide range of process conditions. They also provide good prediction accuracy and deeper insights into the process. The simulation models do not require any pre-simulation, experimental or analytical results, making them highly suitable and widely used for the reliable prediction of process outcomes. The book is based on selected proceedings of AIMTDR 2016. The chapters discuss topics relating to various simulation techniques, such as computational fluid dynamics, heat flow, thermo-mechanical analysis, molecular dynamics, multibody dynamic analysis, and operational modal analysis. These simulation techniques are used to: 1) design the components, 2) to investigate the effect of critical process parameters on the process outcome, 3) to explore the physics of the process, 4) to analyse the feasibility of the process or design, and 5) to optimize the process. A wide range of advanced manufacturing processes are covered, including friction stir welding, electro-discharge machining, electro-chemical machining, magnetic pulse welding, milling with MQL (minimum quantity lubrication), electromagnetic cladding, abrasive flow machining, incremental sheet forming, ultrasonic assisted turning, TIG welding, and laser sintering. This book will be useful to researchers and professional engineers alike.

The first edition of Minimally Processed and Refrigerated Fruits and Vegetables, edited by Robert C. Wiley and Fatih Yildiz, was published in 1994. At the time of publication, this was a new concept and was well-received by the scientific community. Minimally processed foods are whole plant tissues (the identity of the plant tissue is recognized by consumers), which may contain active enzymes, live tissues, and plant cells. These are some of the basics for the healthy food design.The overall function of these foods is to provide convenient (ready-to-serve, ready-to cook, free of any pesticides and contaminants),like-fresh products for food service and retail consumers. Minimally Processed and Refrigerated Foods (MPR) have been popular in many countries. The following are some of the advantages offered by MPR produce foods: 1. Ease of portion control in the food service industry 2. Lower transportation cost (all inedible portions of the produce are removedprior to transportation) 3. No waste is generated at the point of consumption 4. Utilization and recycling of the waste is much easier 5. Value-added new fruit and vegetable products and meal development is possible and easy 6. No requirement is needed for phytosanitary control during trade 7-No glycation end products formation during processing, 8.Degree of food processing is minimized for optimal health of human, the processing plant for MPR produce, which is not addressed in any other books on this topic, will be described in this second edition. Also, comparison of minimal processing technologies with other technologies was explained in the first publication and will be updated in this second edition. During the last 200 years the purpose of food processing was a-safety(sterilization, Pasteurization,1804 Nicholas Apert,Pasteur 1867), and b-prevention of deficiency diseases(Enrichments),but MPR foods provides a two new dimensions to food processing ; a-Prevention of chronic diseases(bioactive compounds) and b-Optimum health (functional foods,Superfoods,Neutraceuticals, and Medical foods) for human.

This collection represents a single volume of technical papers presented at the Annual International DIC Society Conference and SEM Fall Conference organized by the Society for Experimental Mechanics and Sandia National Laboratories and held in Philadelphia, PA, November 7-10, 2016. The volume presents early findings from experimental, standards development and various other investigations concerning digital image correlation - an important area within Experimental Mechanics. The area of Digital Image Correlation has been an integral track within the SEM Annual Conference spearheaded by Professor Michael Sutton from the University of South Carolina. In 2016, the SEM and Sandia joined their collaborative strengths to launch a standing fall meeting focusing specifically on developments in the area of Digital Image Correlation. The contributed papers within this volume span numerous technical aspects of DIC including standards development for the industry.

The Springer Handbook of Odor is the definitive guide to all aspects related to the study of smell and their impact on human life. For the first time, this handbook aligns the senso-chemo-analytical characterization of everyday smells encountered by mankind, with the elucidation of perceptual, hedonic, behavioral and physiological responses of humans to such odors. From birth onwards we learn to interact with our environment using our sense of smell. Moreover, evolutionary processes have engendered a multi-faceted communication that is supported – even dominated – by olfaction. This compilation examines the responses of humans to odors at different stages of life, thereby building a foundation for a widely overseen area of research with broader ramifications for human life. The expert international authors and editor align aspects, concepts, methodologies and perspectives from a broad range of different disciplines related to the science of smell. These include chemistry, physiology, psychology, material sciences, technology but also disciplines related to linguistics, culture, art and design.This handbook, edited by an internationally renowned aroma scientist with the support of an outstanding team of over 60 authors, is an authoritative reference for researchers in the field of odors both in academia and in industry and is also a useful reference for newcomers to the area.

Advancement of Optical Methods in Experimental Mechanics, Volume 3 of the Proceedings of the 2016 SEM Annual Conference & Exposition on Experimental and Applied Mechanics, the third volume of ten from the Conference, brings together contributions to this important area of research and engineering. The collection presents early findings and case studies on a wide range of optical methods ranging from traditional photoelasticity and interferometry to more recent DIC and DVC techniques, and includes papers in the following general technical research areas: Advances in Digital Image CorrelationChallenging Applications of DICUncertainty Analysis & Improvements to DIC AccuracyPhotoelasticity, Interferometry, & Moire MethodsApplications of StereovisionInverse Methods at High Strain RatesInverse Methods in Plasticity

Challenges in Mechanics of Time-Dependent Materials, Volume 2 of the Proceedings of the 2016 SEM Annual Conference& Exposition on Experimental and Applied Mechanics, the second volume of ten from the Conference, brings together contributions to this important area of research and engineering. The collection presents early findings and case studies on fundamental and applied aspects of Experimental Mechanics, including papers in the following general technical research areas: Extreme Environments & Environmental EffectsStructure-Function of Performance of PEEffects of Inhomogeneities & InterfacesCharacterization Across ScalesMechanics of Energy & Energetic MaterialsMetallic MaterialsViscoelasticity & Viscoplasticity

This unique volume salutes the work of pioneering forensic psychologist Lawrence S. Wrightsman, Jr., by presenting current theorizing and research findings on issues that define the field of psychology and law. Ongoing topics in witness behaviors, suspect identification, and juror decision making illustrate how psychology and law complement and also conflict at various stages in legal processes. The book also sheds light on evolving areas such as DNA exonerations, professional trial consulting, and jury selection strategies, and the distinct challenges and opportunities these issues present. Noted contributors to the book include Wrightsman himself, who offers salient observations on the field that he continues to inspire. Featured among the topics: The credibility of witnesses.Psychological science on eyewitness identification and the U.S. Supreme Court.False confessions, from colonial Salem to today.Identifying juror bias: toward a new generation of jury selection research.Law and social science: how interdisciplinary is interdisciplinary enough?Race and its place in the American legal system.With its diverse mix of perspectives and methodologies, The Witness Stand and Lawrence S. Wrightsman, Jr. will interest forensic researchers in academic and applied settings, as well as individuals working in the legal system, such as attorneys, judges and law enforcement personnel.

The book focuses on the understanding of molecular pathways by which normal cell progress to the definable stage of cancer. The chapters explore microbiota and chronic inflammation, multiple myeloma chemoprevention, microRNAs, cancer regulation, liquid biopsies, and angiogenesis. Recent advances of molecular risk assessment, tumor microenvironment, microneoplasia, malignant gene expressions are highlighted to provide a means and design of future cancer prevention strategies and challenges thereupon. The volume also explores various receptor drugs that are in development process with the emphasis of inhibitors used to prevent malignant gene expression. The book bridges the gap between basic science and clinical application of current knowledge of cancer and emphasizes that tumor progression and cancer metastasis are not random - treatments and cure are logical and eventual.Expertly authored and drawing from a wealth of international perspectives, Molecular Targetsand Strategies in Cancer Prevention is invaluable reading for clinicians and researchers in the fields of oncology and molecular biology.

This volume is the first text to concisely yet comprehensively cover developments for both alcoholic and nonalcoholic fatty liver disease in an organized fashion. Aspects of these two diseases covered in the book include global epidemiology and risk factors, pathogenesis, animal models, hepatic and extra-hepatic malignancies, treatment models, and current and emerging therapies. Written by experts in the field, Alcoholic and Non-Alcoholic Fatty Liver Disease: Bench to Bedside is a valuable resource for gastroenterologists, pathologists, and hepatologists who treat patients with alcoholic and nonalcoholic fatty liver disease.

This book brings together philosophical approaches to cooperation and collective agency with research into human-machine interaction and cooperation from engineering, robotics, computer science and AI. Bringing these so far largely unrelated fields of study together leads to a better understanding of collective agency in natural and artificial systems and will help to improve the design and performance of hybrid systems involving human and artificial agents. Modeling collective agency with the help of computer simulations promises also philosophical insights into the emergence of collective agency.The volume consists of four sections. The first section is dedicated to the concept of agency. The second section of the book turns to human-machine cooperation. The focus of the third section is the transition from cooperation to collective agency. The last section concerns the explanatory value of social simulations of collective agency in the broader framework of cultural evolution.

This is an up-to-date, comprehensive review of the neuropsychiatry of patients with movement disorders, i.e. Parkinson's disease, Huntington's disease, dystonia and others, by active authorities in the field, with an emphasis on diagnostic and management issues.This book includes critical appraisal of the methodological aspects and limitations of the current research on the neuropsychiatry of movement disorders and on unanswered questions/controversies. Symptomatology and pharmacological aspects of management are discussed, to provide robust information on drug dosages, side effects and interaction, in order to enable the reader to manage these patients more safely. Illustrative cases provide real life scenarios that are clinically relevant and engaging to read.Neuropsychiatric Symptoms of Movement Disorders is aimed at neurologists, movement disorder specialists and psychiatrists and will also be of interest to intensive care doctors, psychologists and neuropsychologists, research and specialist nurses, clinical researchers and methodologists.

During the last 20 years the Portuguese association of automatic control, Associação Portuguesa de Controlo Automático, with the sponsorship of IFAC have established the CONTROLO conference as a reference international forum where an effective exchange of knowledge and experience amongst researchers active in various theoretical and applied areas of systems and control can take place, always including considerable space for promoting new technical applications and developments, real-world challenges and success stories. In this 11th edition the CONTROLO conference evolved by introducing two strategic partnerships with Spanish and Brazilian associations in automatic control, Comité Español de Automática and Sociedade Brasileira de Automatica, respectively.

This volume presents a concise yet comprehensive overview on all facets concerning the complications of cirrhosis. Structured in three sections, the book reviews the natural history of cirrhosis, the diagnostic and predictive tools available to assess the disease, complications, and treatment options such as liver assist devices and transplantation. Topical concerns in the management of patients with cirrhosis are also addressed, including issues pertaining to the delivery of quality care in this patient population.Written by experts in their fields, Complications of Cirrhosis: Evaluation and Management serves as a valuable resource for practitioners and physicians-in-training on the subject of cirrhosis.

This book contains a selection of papers presented at the 17th AISEM (“Associazione Italiana Sensori e Microsistemi”) National Conference on Sensors and Microsystems, held in Brescia, 5-7 February, 2013. The conference highlighted state-of-the-art results from both theoretical and applied research in the field of sensors and related technologies. This book presents material in an interdisciplinary approach, covering many aspects of the disciplines related to sensors, including physics, chemistry, materials science, biology and applications.

Advancement of Optical Methods in Experimental Mechanics, Volume 3: Proceedings of the 2014 Annual Conference on Experimental and Applied Mechanics, the third volume of eight from the Conference, brings together contributions to this important area of research and engineering. The collection presents early findings and case studies on a wide range of optical methods ranging from traditional photoelasticity and interferometry to more recent DIC and DVC techniques, and includes papers in the following general technical research areas:· Advanced optical methods for frontier applications· Advanced optical interferometry· Optical measurement systems using polarized light· Optical methods for advanced manufacturing · Digital image correlation· Optical methods at the micro/nano-scale· Three-dimensional imaging and volumetric correlation· Imaging methods for thermomechanics applications· Opto-acoustical methods in experimental mechanics· Optical measurements in challenging environments· Optical methods for inverse problems· Advances in optical methods

This volume contains most of the papers presented at the Sym­ posium on Affinity Chromatography and Immobilized Biochemicals, which was held on November 7-9, 1973 in Charleston, South Carolina in conjunction with the Southeastern Regional American Chemical Society meeting. The topics of the symposium represent two new biochemical frontiers which have emerged in recent years through the ingenious development and application of solid phase biochemi­ cal technologies. Affinity chromatography involves the use of selected ligands, covalently bound to a solid support such as cel­ lulose, glass, Sepharose, or polyacrylamide and exploits the princi­ ple of biochemical recognition between the ligand in the solid phase and a selected macromolecule to facilitate the rapid and often quantitative purification of enzymes, antibodies, antigens, hormones, other proteins, etc. The area of immobilized biochemicals includes the use of coenzymes, oligo- and po1ynuc1eotides, enzymes, and multistep enzyme systems which are immobilized or entrapped in the solid phase. The goals of the symposium were the revi~w of the status of affinity chromatography and immobilized biochemicals, the presentation of new data and ideas in both areas, and the establish­ ment of a dialogue between research workers in these two evolving disciplines which are so closely interrelated. The papers published in this volume provide the reader with reviews of several topics inherent in the solid phase biochemistry together with a series of timely manuscripts concerning new techniques and applications both in the use of affinity chromatography and in the investigation of immobilized biochemicals.